Analysis of the Broad’s Avana CRISPR (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017) and the Broad and Dana-Farber Cancer Institite’s Achilles shRNA (MacFarland et al. 2018, Data Science 2018).
The Avana screen produced results using CERES (Meyers et al. 2017) (GitHub), which generates gene dependency scores from sgRNA depletion scores from gene essentiality screens and eliminates bias arising from the effect of copy number variation on Cas9 DNA cleavage. The lower the CERES score, the higher the likelihood that the gene is essential in the associated cell line. Scores are scaled per cell line such that a score of 0 is the median effect of nonessential genes and -1 is the median effect of common core essential genes.
In a previous version of the shRNA screen, DEMETER (GitHub) was used to compute a dependency score for each gene by using the depletion values from each shRNA to infer the effect of target knockdown (on-target) and of expressing a given miRNA seed (off-target) in each cell line. More negative values indicate increased dependency, while more positive values indicate lower dependency. Zero represents the avergae dependency across all cell lines.
In the new data release, DEMETER2 (GitHub repository), developed by McFarland et al. (2018) was used to analyze the Achilles screen. DEMETER2 expands on DEMETER by including parameters for cell-line-specific screen effects and noisy data, correcting for global differences in shRNA levels across cell lines, pooling data acorss cell lines via hierarchical modeling, and using Bayesian inference to compute uncertainty estimates. Now, a score of zero represents no dependency.
All annotation files (copy number, mutation status, and gene expression) (Consortium and Consortium 2015, Barretina et al. 2012) were downloaded from the DepMap Data Portal.
Load libraries.
library(broom)
library(bsselectR)
library(caret)
library(CePa)
library(circlize)
library(ComplexHeatmap)
library(data.table)
library(devtools)
library(ggpubr)
library(ggsignif)
library(ggfortify)
library(ggord)
library(glmnet)
library(gridExtra)
library(jsonlite)
library(jsonlite)
library(kableExtra)
library(magrittr)
library(matrixStats)
library(NMF)
library(parallel)
library(plyr)
library(reshape2)
library(rowr)
library(tidyverse)
adj_signif <- function(df) {
# Takes df from compare_means and creates a signif code column for adjusted p-vals
df$p.signif <- ifelse(df$p.signif == "ns", NA, df$p.signif)
df$p.signif.adj <- ifelse(df$p.adj <= 0.0001, "****",
ifelse(df$p.adj <= 0.001, "***",
ifelse(df$p.adj <= 0.01, "**",
ifelse(df$p.adj <= 0.05, "*", NA))))
df$p.short <- formatC(df$p, format = "g", digits = 2)
df$p.adj.short <- formatC(df$p.adj, format = "g", digits = 2)
return(df)
}
makeCRISPRgrob <- function(g, filt_method) {
if(filt_method == "lvlA") {
gene <- filter(crispr_data_lvlA, Hugo_Symbol == g)
sig <- filter(crispr_signif_lvlA, Hugo_Symbol == g)
}
if(filt_method == "all") {
gene <- filter(crispr_data_ptmuts, Hugo_Symbol == g)
sig <- filter(crispr_signif_nonsilent, Hugo_Symbol == g)
}
# Mutation status
crispr_color <- as.character(gene$Color_Nonsilent)
names(crispr_color) <- gene$Mutation_Status_Nonsilent
plot_mut <- ggplot(data = gene, aes(x = Mutation_Status_Nonsilent, y = Score, color = Mutation_Status_Nonsilent)) +
geom_boxplot(outlier.shape = NA) +
geom_jitter(alpha = 0.3, size = 0.7, position = position_jitter(w = 0.05)) +
scale_color_manual(values = crispr_color) +
geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
theme_light() +
theme(legend.position = "none") +
labs(x = paste0(g, " Mutation Status"), y = "CERES Score",
title = "Mutation Status",
subtitle = paste0("Wilcoxon test:\n- BH-corrected p-value: ", sig$p.adj.short, "\n- Uncorrected p-value: ", sig$p.short))
# Copy number
lo_cn <- range(gene$Copy_Number[!is.na(gene$Copy_Number)])[1]
hi_cn <- range(gene$Copy_Number[!is.na(gene$Copy_Number)])[2]
mid_cn <- (hi_cn - lo_cn) / 2
plot_cn <- ggplot(data = gene, aes(x = Copy_Number, y = Score, color = Mutation_Status_Nonsilent)) +
geom_point(size = 0.5, alpha = 0.5) +
geom_smooth(method = "lm", size = 0.5) +
geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
scale_color_manual(values = crispr_color) +
stat_cor(method = "pearson", show.legend = FALSE, label.x = c((lo_cn + mid_cn) / 2, (hi_cn - mid_cn) / 2 + mid_cn), label.y = max(gene$Score)) +
theme(legend.position = "none") +
labs(y = "CERES Score", color = "Mutation Status",
x = paste0(g, " Theoretical Copy number"), title = "Copy Number",
subtitle = "r: Pearson correlation coeffcient")
# Gene expression
lo_ge <- range(gene$RPKM_log2[!is.na(gene$RPKM_log2)])[1]
hi_ge <- range(gene$RPKM_log2[!is.na(gene$RPKM_log2)])[2]
mid_ge <- (hi_ge - lo_ge) / 2
plot_ge <- ggplot(data = gene, aes(x = RPKM_log2, y = Score, color = Mutation_Status_Nonsilent)) +
geom_point(size = 0.5, alpha = 0.5) +
geom_smooth(method = "lm", size = 0.5) +
geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
scale_color_manual(values = crispr_color) +
stat_cor(method = "pearson", show.legend = FALSE, label.x = c((lo_ge + mid_ge) / 2, (hi_ge - mid_ge) / 2 + mid_ge), label.y = max(gene$Score)) +
theme(legend.position = "none") +
labs(y = "CERES Score", color = "Mutation Status",
x = paste0(g, " Gene Expression [log2(RPKM)]"),
title = "Gene Expression",
subtitle = "r: Pearson correlation coeffcient")
# Cell line lineage
plot_tissue <- ggplot(data = gene, aes(x = primary_tissue, y = Score, color = Mutation_Status_Nonsilent)) +
geom_point(alpha = 0.5) +
scale_color_manual(values = crispr_color) +
geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
scale_y_continuous(sec.axis = sec_axis(~ .)) +
coord_flip() +
theme(legend.position = "none") +
labs(y = "CERES Score", x = "Primary Tissue",
color = "Mutation Status", title = g)
# Arrange plots
plot <- ggarrange(ggarrange(plot_tissue, nrow = 1, labels = c("A")),
ggarrange(plot_mut, plot_cn, plot_ge, nrow = 3,
labels = c("B", "C", "D"), heights = c(2, 3, 3)),
font.label = list(size = 30, face = "bold"),
nrow = 1, ncol = 2, widths = c(3, 2))
return(plot)
}
makeCRISPRlinplot <- function(g) {
sig <- filter(crispr_signif_lineage, Hugo_Symbol == g)
if(nrow(sig) == 0) {
return(NULL)
}
else {
gene <- filter(crispr_data, Hugo_Symbol == g)
gene <- merge(gene, sig, by = c("Hugo_Symbol", "group_general_lineage_name"))
gene <- mutate(gene, group_general_lineage_name = reorder(group_general_lineage_name, p, mean))
crispr_color <- as.character(gene$Color)
names(crispr_color) <- gene$Mutation_Status
score_range <- abs(range(gene$Score)[2] - range(gene$Score)[1])
round_accuracy <- ifelse(score_range <= 2, 0.25,
ifelse(score_range <= 3, 0.5, 1.0))
plot <- ggplot(data = gene, aes(x = group_general_lineage_name, y = Score)) +
geom_point(alpha = 0.5, mapping = aes(color = Mutation_Status)) +
scale_color_manual(values = crispr_color) +
coord_cartesian(y = c(min(gene$Score), round_any(x = max(gene$Score), accuracy = round_accuracy, f = ceiling))) +
geom_signif(data = gene, mapping = aes(xmin = group_general_lineage_name, xmax = group_general_lineage_name, annotations = paste(p.short, "\n", p.adj.short), y_position = max(gene$Score)), manual = TRUE, tip_length = 0, size = 0, textsize = 3) +
theme(legend.position = "top", axis.text.x = element_text(angle = 70, hjust = 1, size = 10)) +
labs(y = "CERES Score",
x = "Lineage",
color = "Mutation Status",
title = paste0(g, ": CERES score by cell line lineage"),
subtitle = "Lineages sorted by increasing p-value; labels indicate unadjusted p-value / BH-corrected p-value.\nMutant lines harbor deleterious mutations.")
return(plot)
}
}
WilcoxonByDrug <- function(drug, dataset, data_name) {
use_data <- filter(dataset, Drug == drug)
sig <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Hugo_Symbol", data = use_data, method = "wilcox.test", p.adjust.method = "BH")
sig <- adj_signif(sig)
sig <- sig[order(sig$p),]
sig$Drug <- drug
sig$Dataset <- data_name
return(sig)
}
makeDrugBoxplots <- function(drug, dataset) {
if(dataset == "CCLE" | dataset == "ccle") {
use_data <- filter(ccle_ptmuts_lvlA_filt, Drug == drug)
use_color <- as.character(use_data$Color_Nonsilent)
names(use_color) <- use_data$Mutation_Status_Nonsilent
sig <- ccle_signif_lvlA_ByDrug[[drug]]
# sig <- filter(ccle_signif_lvlA, Drug == drug)
label_text <- data.frame(p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
label_text <- filter(label_text, Hugo_Symbol %in% genes_lvlA_filt)
label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = genes_lvlA_filt)
}
else if(dataset == "CTRP" | dataset == "ctrp") {
use_data <- filter(ctrp_ptmuts_lvlA_filt, Drug == drug)
use_color <- as.character(use_data$Color_Nonsilent)
names(use_color) <- use_data$Mutation_Status_Nonsilent
sig <- ctrp_signif_lvlA_ByDrug[[drug]]
# sig <- filter(ctrp_signif_lvlA, Drug == drug)
label_text <- data.frame(p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
label_text <- filter(label_text, Hugo_Symbol %in% genes_lvlA_filt)
label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = genes_lvlA_filt)
}
else if(dataset == "GDSC" | dataset == "gdsc") {
use_data <- filter(gdsc_ptmuts_lvlA_filt, Drug == drug)
use_color <- as.character(use_data$Color_Nonsilent)
names(use_color) <- use_data$Mutation_Status_Nonsilent
sig <- gdsc_signif_lvlA_ByDrug[[drug]]
# sig <- filter(gdsc_signif_lvlA, Drug == drug)
label_text <- data.frame(p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
label_text <- filter(label_text, Hugo_Symbol %in% genes_lvlA_filt)
label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = genes_lvlA_filt)
}
else { return("Error: Invalid dataset.") }
plot <- ggplot(data = use_data, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
facet_wrap(~ Hugo_Symbol, drop = FALSE, ncol = length(genes_lvlA_filt)) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85)) +
scale_fill_manual(values = use_color) +
guides(color = FALSE) +
geom_text(data = label_text, mapping = aes(x = 1.5, y = max(use_data$AUC), label = p.signif.adj)) +
theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
labs(fill = "Mutation Status", y = "AUC", x = "Mutation Status", title = paste0(dataset, ": ", drug))
return(plot)
}
This comprehensive cancer cell line information curated by Daniel Charytonowicz.
ccl_converter <- read.delim("./data_munging/cell_line_database_v1_20180911.tsv", row.names = 1, sep = "\t", header = TRUE)
Select genes from the Cancer Gene Census (CGC). The list was pulled from the International Cancer Genome Consortium (ICGC) data portal (Advaced Search > Genes > Curated Gene Set > Cancer Gene Census).
cgc <- data_frame("Hugo_Symbol" = read.delim("./data_munging/gene-ids-for-set-Cancer Gene Census.tsv", header = FALSE, sep = "\t")[, 2])
ccl_info <- read.delim("./data_munging/DepMap-2018q3-celllines.csv", sep = ",", header = TRUE, na.strings = c("", NA))
ccl_info$Primary.Disease <- gsub("\\\\", "", ccl_info$Primary.Disease)
ccl_info$Primary.Disease <- gsub("Ewings", "Ewing's", ccl_info$Primary.Disease)
# From figshare
crispr_meta <- read.delim("./data_munging/sample_info_18Q3_crispr.csv", sep = ",", header = TRUE, na.strings = c("", NA))
colnames(crispr_meta)[7] <- "CCLE_Name"
For mutation calling, get paired gene name and cell line fields in a data frame. For this analysis, we don’t care about how many mutations there are per gene or what type of mutations there are, so I didn’t save more information. I took unique gene-cell line combinations since we only cared about mutation presence/absence. Add a Mutation_Status column denoting all entries in MAF files as mutations present in the associated cell lines.
maf_raw <- read.delim("./data_munging/CCLE_DepMap_18q3_maf_20180718.txt.gz", header = TRUE, sep = "\t")
# Filter for cell lines in CRISPR screen
maf_raw <- filter(maf_raw, Broad_ID %in% unique(crispr_meta$Broad_ID))
colnames(maf_raw)[colnames(maf_raw) == "Tumor_Sample_Barcode"] <- "CCLE_Name"
# Select columns
maf_df <- subset(maf_raw, select = c("Hugo_Symbol", "CCLE_Name", "Broad_ID", "Variant_Classification", "Reference_Allele", "Tumor_Seq_Allele1"))
maf_df$Reference_Allele_Length <- ifelse(maf_df$Reference_Allele == "-", 0, nchar(as.character(maf_df$Reference_Allele)))
maf_df$Tumor_Seq_Allele1_Length <- nchar(as.character(maf_df$Tumor_Seq_Allele1))
# Add Mutation_Status column
maf_df$Mutation_Status_Nonsilent <- ifelse(maf_df$Variant_Classification == "Silent", "Other", "Mutant")
maf_df <- unique(subset(maf_df, select = c("Hugo_Symbol", "CCLE_Name", "Broad_ID", "Mutation_Status_Nonsilent", "Reference_Allele_Length", "Tumor_Seq_Allele1_Length")))
# Whole MAF summary table
maf_summ <- maf_raw[, c("Variant_Classification", "isDeleterious")] %>% group_by(Variant_Classification, isDeleterious) %>% tally()
maf_summ$Percent <- format(round(maf_summ$n / sum(maf_summ$n) * 100, 4), nsmall = 2)
maf_summ$isDeleterious <- ifelse(maf_summ$isDeleterious == "TRUE", "Yes", "No")
knitr::kable(maf_summ, caption = "Distribution of variant classifications in the MAF file") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive"))
| Variant_Classification | isDeleterious | n | Percent |
|---|---|---|---|
| 3’UTR | No | 1 | 0.0003 |
| 3’UTR | Yes | 30 | 0.0084 |
| 5’Flank | No | 8 | 0.0022 |
| 5’Flank | Yes | 34 | 0.0095 |
| 5’UTR | No | 2 | 0.0006 |
| 5’UTR | Yes | 15 | 0.0042 |
| De_novo_Start_OutOfFrame | Yes | 2006 | 0.5595 |
| Frame_Shift_Del | Yes | 12441 | 3.4698 |
| Frame_Shift_Ins | Yes | 9215 | 2.5701 |
| IGR | No | 6 | 0.0017 |
| IGR | Yes | 44 | 0.0123 |
| In_Frame_Del | No | 1747 | 0.4872 |
| In_Frame_Ins | No | 442 | 0.1233 |
| Intron | No | 9 | 0.0025 |
| Intron | Yes | 187 | 0.0522 |
| Missense_Mutation | No | 211359 | 58.9484 |
| Nonsense_Mutation | Yes | 12711 | 3.5451 |
| Nonstop_Mutation | Yes | 335 | 0.0934 |
| Silent | No | 94225 | 26.2795 |
| Splice_Site | Yes | 13180 | 3.6759 |
| Start_Codon_Del | Yes | 25 | 0.0070 |
| Start_Codon_Ins | Yes | 33 | 0.0092 |
| Start_Codon_SNP | No | 402 | 0.1121 |
| Stop_Codon_Del | No | 1 | 0.0003 |
| Stop_Codon_Del | Yes | 52 | 0.0145 |
| Stop_Codon_Ins | Yes | 39 | 0.0109 |
cn <- read.delim("./data_munging/public_18Q3_gene_cn_v2.csv.gz", sep = ",", check.names = FALSE, header = TRUE)
# Convert log2 ratios (log2(CN/2)) to CN
cn[2:ncol(cn)] <- lapply(cn[2:ncol(cn)], function(x) 2 * (2 ^ x))
# Remove Entrez gene IDs from colnames
colnames(cn) <- gsub(" .*", "", colnames(cn))
colnames(cn)[1] <- "Broad_ID"
# Melt
cn_melt <- melt(data = cn, id.vars = "Broad_ID", measure.vars = colnames(cn[2:ncol(cn)]), variable.name = "Hugo_Symbol", value.name = "Copy_Number")
saveRDS(cn_melt, "./data_munging/rds/cn_melt_18Q3.rds", compress = "xz")
cn_melt <- readRDS("./data_munging/rds/cn_melt_18Q3.rds")
Gene expression data (Reads Per Kilobase of transcript, per Million mapped reads, RPKM).
ge <- read.delim("./../crispr_lineages_giant_files/CCLE_DepMap_18q3_RNAseq_RPKM_20180718.gct.gz", skip = 2, header = TRUE, sep = "\t", check.names = FALSE)
# Edit columns
ge$Name <- NULL
colnames(ge)[1] <- "Hugo_Symbol"
# Melt
ge_melt <- melt(data = ge, id.vars = "Hugo_Symbol", measure.vars = colnames(ge[2:ncol(ge)]), value.name = "RPKM")
## Split variable column
ge_melt <- with(ge_melt, cbind(Hugo_Symbol, colsplit(variable, pattern = " ", names = c("CCLE_Name", "Broad_ID")), RPKM))
## Remove parentheses around Broad IDs
ge_melt$Broad_ID <- gsub("\\(|\\)", "", ge_melt$Broad_ID)
saveRDS(ge_melt, "./../crispr_lineages_giant_files/ge_melt_18Q3.rds", compress = "xz")
ge_melt <- readRDS("./../crispr_lineages_giant_files/ge_melt_18Q3.rds")
dep <- read.delim("./data_munging/gene_dependency_18Q3.csv.gz", sep = ",", header = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(dep) <- gsub(" .*", "", colnames(dep))
The latest CRISPR CERES score data (18Q3, August 2018) was pulled from the DepMap Data Portal (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017).
crispr <- read.delim("./data_munging/gene_effect_18Q3.csv.gz", sep = ",", header = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(crispr) <- gsub(" .*", "", colnames(crispr))
Merge annotation data:
# Melt CRISPR dataset for merging
crispr_melt <- melt(crispr, id.vars = "Broad_ID", measure.vars = colnames(crispr)[2:ncol(crispr)], variable.name = "Hugo_Symbol", value.name = "Score")
# Melt dependency probabilities dataset for merging
dep_melt <- melt(dep, id.vars = "Broad_ID", measure.vars = colnames(dep)[2:ncol(dep)], variable.name = "Hugo_Symbol", value.name = "Dep_Prob")
# Merge dependency probabilities
crispr_melt <- merge(crispr_melt, dep_melt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
# Merge cell line metadata
crispr_melt <- merge(crispr_melt, ccl_info, by = "Broad_ID", all.x = TRUE)
crispr_melt <- merge(crispr_melt, crispr_meta, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
# Merge mutation annotations
crispr_muts <- merge(crispr_melt, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
crispr_muts$Hugo_Symbol <- factor(crispr_muts$Hugo_Symbol)
crispr_muts <- crispr_muts %>% mutate(Mutation_Status_Nonsilent = if_else(is.na(Mutation_Status_Nonsilent), "Other", Mutation_Status_Nonsilent))
# Summarize number of mutant and Other cell lines
crispr_muts_summ <- crispr_muts %>% group_by(Hugo_Symbol) %>%
summarize(N_Nonsilent_Other = sum(Mutation_Status_Nonsilent == "Other"),
N_Nonsilent_Mutant = sum(Mutation_Status_Nonsilent == "Mutant"))
# Merge test results back into full dataset, which restores information lost in the summarization
crispr_data <- merge(crispr_muts_summ, crispr_muts, by = "Hugo_Symbol")
# Add Color columns
crispr_data$Color_Nonsilent <- ifelse(crispr_data$Mutation_Status_Nonsilent == "Other", "thistle", "darkorchid")
crispr_data$Color_Nonsilent <- factor(crispr_data$Color_Nonsilent)
# Cell line lineages
crispr_data <- merge(crispr_data, ccl_converter, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
levels(crispr_data$lineage_name) <- sort(levels(crispr_data$lineage_name), decreasing = TRUE)
# Copy number
crispr_data <- merge(crispr_data, cn_melt, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)
# Gene expression (RPKM)
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol) & Broad_ID %in% unique(crispr_data$Broad_ID))
crispr_data <- merge(crispr_data, ge_filt, by = c("Hugo_Symbol", "Broad_ID", "CCLE_Name"), all.x = TRUE)
crispr_data$RPKM_log2 <- log2(crispr_data$RPKM + 0.0001)
saveRDS(crispr_data, "./../crispr_lineages_giant_files/crispr_data_18Q3.rds", compress = "xz")
crispr_data <- readRDS("./../crispr_lineages_giant_files/crispr_data_18Q3.rds")
crispr_ccl <- data.frame("Broad_ID" = crispr_data$Broad_ID)
# write.table(crispr_data, file = "~/Desktop/crispr_data.tsv", quote = FALSE, sep = "\t")
g2p <- read.delim("./data_munging/g2p_full_level_A_dataset_v2_10_10_2018.tsv", sep = "\t", header = TRUE)
genes_lvlA_df <- data.frame(Hugo_Symbol = unique(g2p$Gene))
genes_lvlA <- unique(g2p$Gene)
# Drug metadata
drug_meta <- read.delim("./data_munging/drug_id_drug_name_table_10_12_2018.tsv", sep = "\t", header = FALSE)
colnames(drug_meta) <- c("CID", "Drug")
drug_meta$Drug <- tolower(drug_meta$Drug)
maf_df_lvlA <- filter(maf_df, Hugo_Symbol %in% genes_lvlA)
# CCLE
ccle <- read.delim("./data_munging/data_drug_auc_ccle_10_12_2018.csv", sep = "\t", header = TRUE, row.names = 1, check.names = FALSE)
ccle <- merge(drug_meta, ccle, by = "CID")
ccle_melt <- melt(ccle, id.vars = c("CID", "Drug"), measure.vars = colnames(ccle)[3:ncol(ccle)], variable.name = "accession_id", value.name = "AUC")
ccle_grid <- expand.grid("accession_id" = unique(ccle_melt$accession_id), "Hugo_Symbol" = genes_lvlA)
ccle_data <- merge(ccle_grid, ccle_melt, by = "accession_id", all.x = TRUE)
ccle_data <- merge(ccle_data, ccl_converter, by = "accession_id", all.x = TRUE)
ccle_data <- merge(ccle_data, maf_df_lvlA, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ccle_data$Mutation_Status_Nonsilent <- ifelse(is.na(ccle_data$Mutation_Status_Nonsilent), "Other", ccle_data$Mutation_Status_Nonsilent)
ccle_data$Hugo_Symbol <- factor(ccle_data$Hugo_Symbol)
ccle_data$AUC <- as.numeric(ccle_data$AUC)
ccle_data$Color_Nonsilent <- ifelse(ccle_data$Mutation_Status_Nonsilent == "Other", "palegreen3", "springgreen4")
ccle_data$Color_Nonsilent <- factor(ccle_data$Color_Nonsilent)
ccle_data <- filter(ccle_data, !is.na(ccle_data$AUC))
saveRDS(ccle_data, "./data_munging/rds/ccle_data_18Q3.rds", compress = "xz")
# CTRP
ctrp <- read.delim("./data_munging/data_drug_auc_ctrp_10_12_2018.csv", sep = "\t", header = TRUE, row.names = 1, check.names = FALSE)
ctrp <- merge(drug_meta, ctrp, by = "CID")
ctrp_melt <- melt(ctrp, id.vars = c("CID", "Drug"), measure.vars = colnames(ctrp)[3:ncol(ctrp)], variable.name = "accession_id", value.name = "AUC")
ctrp_grid <- expand.grid("accession_id" = unique(ctrp_melt$accession_id), "Hugo_Symbol" = genes_lvlA)
ctrp_data <- merge(ctrp_grid, ctrp_melt, by = "accession_id", all.x = TRUE)
ctrp_data <- merge(ctrp_data, ccl_converter, by = "accession_id", all.x = TRUE)
ctrp_data <- merge(ctrp_data, maf_df_lvlA, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ctrp_data$Mutation_Status_Nonsilent <- ifelse(is.na(ctrp_data$Mutation_Status_Nonsilent), "Other", ctrp_data$Mutation_Status_Nonsilent)
ctrp_data$Hugo_Symbol <- factor(ctrp_data$Hugo_Symbol)
ctrp_data$AUC <- as.numeric(ctrp_data$AUC)
ctrp_data$Color_Nonsilent <- ifelse(ctrp_data$Mutation_Status_Nonsilent == "Other", "slategray3", "steelblue4")
ctrp_data$Color_Nonsilent <- factor(ctrp_data$Color_Nonsilent)
ctrp_data <- filter(ctrp_data, !is.na(ctrp_data$AUC))
saveRDS(ctrp_data, "./data_munging/rds/ctrp_data_18Q3.rds", compress = "xz")
# GDSC
gdsc <- read.delim("./data_munging/data_drug_auc_gdsc_10_12_2018.csv", sep = "\t", header = TRUE, row.names = 1, check.names = FALSE)
gdsc <- merge(drug_meta, gdsc, by = "CID")
gdsc_melt <- melt(gdsc, id.vars = c("CID", "Drug"), measure.vars = colnames(gdsc)[3:ncol(gdsc)], variable.name = "accession_id", value.name = "AUC")
gdsc_grid <- expand.grid("accession_id" = unique(gdsc_melt$accession_id), "Hugo_Symbol" = genes_lvlA)
gdsc_data <- merge(gdsc_grid, gdsc_melt, by = "accession_id", all.x = TRUE)
gdsc_data <- merge(gdsc_data, ccl_converter, by = "accession_id", all.x = TRUE)
gdsc_data <- merge(gdsc_data, maf_df_lvlA, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
gdsc_data$Mutation_Status_Nonsilent <- ifelse(is.na(gdsc_data$Mutation_Status_Nonsilent), "Other", gdsc_data$Mutation_Status_Nonsilent)
gdsc_data$Hugo_Symbol <- factor(gdsc_data$Hugo_Symbol)
gdsc_data$AUC <- as.numeric(gdsc_data$AUC)
gdsc_data$Color_Nonsilent <- ifelse(gdsc_data$Mutation_Status_Nonsilent == "Other", "paleturquoise3", "turquoise4")
gdsc_data$Color_Nonsilent <- factor(gdsc_data$Color_Nonsilent)
gdsc_data <- filter(gdsc_data, !is.na(gdsc_data$AUC))
saveRDS(gdsc_data, "./data_munging/rds/ctrp_data_18Q3.rds", compress = "xz")
ccle_data <- readRDS("./data_munging/rds/ccle_data_18Q3.rds")
ctrp_data <- readRDS("./data_munging/rds/ctrp_data_18Q3.rds")
gdsc_data <- readRDS("./data_munging/rds/gdsc_data_18Q3.rds")
test_gdsc <- gdsc_data %>% group_by(Drug, Hugo_Symbol, Mutation_Status_Nonsilent) %>% tally()
Filter for point mutations:
crispr_data_ptmuts <- filter(crispr_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
crispr_data_ptmuts$Keep_PtMut_Tests <- ifelse(crispr_data_ptmuts$Reference_Allele_Length == 1 | is.na(crispr_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(crispr_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
crispr_data_ptmuts <- filter(crispr_data_ptmuts, Keep_PtMut_Tests == TRUE)
test_ptmuts <- filter(crispr_data_ptmuts, is.na(group_general_lineage_name))
test_ptmuts <- filter(crispr_data_ptmuts, Hugo_Symbol == "KRAS")
crispr_signif_nonsilent <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_nonsilent <- adj_signif(crispr_signif_nonsilent)
crispr_signif_nonsilent <- crispr_signif_nonsilent[order(crispr_signif_nonsilent$p),]
saveRDS(crispr_signif_nonsilent, "./data_munging/rds/crispr_signif_ptmuts_nonsilent_gene.rds")
# write.table(crispr_signif_nonsilent, file = "~/Desktop/crispr_signif_ptmuts_nonsilent_gene.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_nonsilent <- readRDS("./data_munging/rds/crispr_signif_ptmuts_nonsilent_gene.rds")
knitr::kable(filter(crispr_signif_nonsilent, p < 0.01)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant vs other cell lines, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|
| KRAS | 0.0000000 | 0.0000000 | < 2e-16 | **** | **** |
| TP53 | 0.0000000 | 0.0000000 | < 2e-16 | **** | **** |
| NRAS | 0.0000000 | 0.0000000 | < 2e-16 | **** | **** |
| BRAF | 0.0000000 | 0.0000000 | < 2e-16 | **** | **** |
| PIK3CA | 0.0000000 | 0.0000000 | 1.5e-14 | **** | **** |
| PTEN | 0.0000000 | 0.0000000 | 2.3e-14 | **** | **** |
| CTNNB1 | 0.0000050 | 0.0122216 | 5.0e-06 | **** |
|
| TCERG1 | 0.0000372 | 0.0797843 | 3.7e-05 | **** | NA |
| ARID1A | 0.0000792 | 0.1510263 | 7.9e-05 | **** | NA |
| TPR | 0.0001525 | 0.2618368 | 0.00015 | *** | NA |
| FCGBP | 0.0002384 | 0.3497129 | 0.00024 | *** | NA |
| SLC22A9 | 0.0002503 | 0.3497129 | 0.00025 | *** | NA |
| GSTM5 | 0.0002648 | 0.3497129 | 0.00026 | *** | NA |
| CPSF1 | 0.0003055 | 0.3746955 | 0.00031 | *** | NA |
| PIGW | 0.0003638 | 0.4164454 | 0.00036 | *** | NA |
| TLX2 | 0.0004787 | 0.5136887 | 0.00048 | *** | NA |
| ARFGAP1 | 0.0005157 | 0.5208132 | 0.00052 | *** | NA |
| TAOK2 | 0.0005481 | 0.5227559 | 0.00055 | *** | NA |
| CD320 | 0.0005816 | 0.5255672 | 0.00058 | *** | NA |
| FBXW7 | 0.0007199 | 0.6008266 | 0.00072 | *** | NA |
| ZNF177 | 0.0007543 | 0.6008266 | 0.00075 | *** | NA |
| SYNPO2L | 0.0007699 | 0.6008266 | 0.00077 | *** | NA |
| HRAS | 0.0008408 | 0.6276668 | 0.00084 | *** | NA |
| KCNIP4 | 0.0009472 | 0.6776073 | 0.00095 | *** | NA |
| PMPCA | 0.0010990 | 0.7063384 | 0.00110 | ** | NA |
| PROM1 | 0.0011974 | 0.7063384 | 0.00120 | ** | NA |
| OR52E8 | 0.0012095 | 0.7063384 | 0.00121 | ** | NA |
| SOX9 | 0.0012690 | 0.7063384 | 0.00127 | ** | NA |
| OR13C4 | 0.0012702 | 0.7063384 | 0.00127 | ** | NA |
| TAS1R2 | 0.0013163 | 0.7063384 | 0.00132 | ** | NA |
| ZNF439 | 0.0013227 | 0.7063384 | 0.00132 | ** | NA |
| ZNF808 | 0.0013587 | 0.7063384 | 0.00136 | ** | NA |
| MTMR2 | 0.0014414 | 0.7063384 | 0.00144 | ** | NA |
| E2F1 | 0.0014486 | 0.7063384 | 0.00145 | ** | NA |
| LPO | 0.0014636 | 0.7063384 | 0.00146 | ** | NA |
| ING2 | 0.0014811 | 0.7063384 | 0.00148 | ** | NA |
| MEF2C | 0.0015423 | 0.7156911 | 0.00154 | ** | NA |
| ACSM2B | 0.0016213 | 0.7325365 | 0.00162 | ** | NA |
| OR8D1 | 0.0017233 | 0.7363894 | 0.00172 | ** | NA |
| RFC1 | 0.0019549 | 0.7363894 | 0.00195 | ** | NA |
| SENP8 | 0.0019559 | 0.7363894 | 0.00196 | ** | NA |
| RUVBL1 | 0.0019950 | 0.7363894 | 0.00200 | ** | NA |
| CLEC4C | 0.0020667 | 0.7363894 | 0.00207 | ** | NA |
| PCDHA8 | 0.0020705 | 0.7363894 | 0.00207 | ** | NA |
| ADAM15 | 0.0021057 | 0.7363894 | 0.00211 | ** | NA |
| KPNA6 | 0.0021334 | 0.7363894 | 0.00213 | ** | NA |
| POU2F1 | 0.0022102 | 0.7363894 | 0.00221 | ** | NA |
| EZH2 | 0.0022431 | 0.7363894 | 0.00224 | ** | NA |
| C14orf39 | 0.0022590 | 0.7363894 | 0.00226 | ** | NA |
| MDN1 | 0.0023292 | 0.7363894 | 0.00233 | ** | NA |
| ATXN2 | 0.0023450 | 0.7363894 | 0.00235 | ** | NA |
| OR51T1 | 0.0023614 | 0.7363894 | 0.00236 | ** | NA |
| METTL17 | 0.0023923 | 0.7363894 | 0.00239 | ** | NA |
| MMRN2 | 0.0024024 | 0.7363894 | 0.00240 | ** | NA |
| TUBB2A | 0.0025373 | 0.7363894 | 0.00254 | ** | NA |
| RAB43 | 0.0025433 | 0.7363894 | 0.00254 | ** | NA |
| PCDHB15 | 0.0026029 | 0.7363894 | 0.00260 | ** | NA |
| DSEL | 0.0026072 | 0.7363894 | 0.00261 | ** | NA |
| CNOT1 | 0.0026329 | 0.7363894 | 0.00263 | ** | NA |
| MAT2B | 0.0026965 | 0.7363894 | 0.00270 | ** | NA |
| VHL | 0.0027587 | 0.7363894 | 0.00276 | ** | NA |
| UTP3 | 0.0028058 | 0.7363894 | 0.00281 | ** | NA |
| RNF208 | 0.0028105 | 0.7363894 | 0.00281 | ** | NA |
| FRMD4B | 0.0030803 | 0.7363894 | 0.00308 | ** | NA |
| SLC26A2 | 0.0030940 | 0.7363894 | 0.00309 | ** | NA |
| DPP7 | 0.0031064 | 0.7363894 | 0.00311 | ** | NA |
| MYH13 | 0.0032183 | 0.7363894 | 0.00322 | ** | NA |
| DIS3L2 | 0.0032847 | 0.7363894 | 0.00328 | ** | NA |
| ANKRD32 | 0.0034117 | 0.7363894 | 0.00341 | ** | NA |
| PIK3R1 | 0.0034493 | 0.7363894 | 0.00345 | ** | NA |
| SCG2 | 0.0034839 | 0.7363894 | 0.00348 | ** | NA |
| TRIM8 | 0.0034895 | 0.7363894 | 0.00349 | ** | NA |
| TELO2 | 0.0035001 | 0.7363894 | 0.00350 | ** | NA |
| HDGFRP2 | 0.0035382 | 0.7363894 | 0.00354 | ** | NA |
| CAMK2B | 0.0035496 | 0.7363894 | 0.00355 | ** | NA |
| ETAA1 | 0.0035617 | 0.7363894 | 0.00356 | ** | NA |
| ST6GALNAC1 | 0.0035708 | 0.7363894 | 0.00357 | ** | NA |
| ZNF493 | 0.0036128 | 0.7363894 | 0.00361 | ** | NA |
| SLC38A7 | 0.0036411 | 0.7363894 | 0.00364 | ** | NA |
| ZNF107 | 0.0036424 | 0.7363894 | 0.00364 | ** | NA |
| KIAA1211L | 0.0036773 | 0.7363894 | 0.00368 | ** | NA |
| SGCD | 0.0037645 | 0.7363894 | 0.00376 | ** | NA |
| KRT83 | 0.0038147 | 0.7363894 | 0.00381 | ** | NA |
| EEF2 | 0.0038473 | 0.7363894 | 0.00385 | ** | NA |
| SUSD5 | 0.0039261 | 0.7363894 | 0.00393 | ** | NA |
| TAAR1 | 0.0039428 | 0.7363894 | 0.00394 | ** | NA |
| GOLGA3 | 0.0040113 | 0.7363894 | 0.00401 | ** | NA |
| CCNL1 | 0.0040186 | 0.7363894 | 0.00402 | ** | NA |
| IQCH | 0.0040748 | 0.7363894 | 0.00407 | ** | NA |
| AVEN | 0.0041277 | 0.7363894 | 0.00413 | ** | NA |
| PLA2G4F | 0.0041433 | 0.7363894 | 0.00414 | ** | NA |
| CD83 | 0.0041819 | 0.7363894 | 0.00418 | ** | NA |
| NIPBL | 0.0042550 | 0.7363894 | 0.00426 | ** | NA |
| EMILIN3 | 0.0042659 | 0.7363894 | 0.00427 | ** | NA |
| SPHK2 | 0.0043100 | 0.7363894 | 0.00431 | ** | NA |
| PSMB4 | 0.0043587 | 0.7363894 | 0.00436 | ** | NA |
| RB1 | 0.0043721 | 0.7363894 | 0.00437 | ** | NA |
| ACHE | 0.0043818 | 0.7363894 | 0.00438 | ** | NA |
| ZNF135 | 0.0045686 | 0.7363894 | 0.00457 | ** | NA |
| CIITA | 0.0045986 | 0.7363894 | 0.00460 | ** | NA |
| BTBD11 | 0.0046148 | 0.7363894 | 0.00461 | ** | NA |
| TPP1 | 0.0046303 | 0.7363894 | 0.00463 | ** | NA |
| NFE2L1 | 0.0046446 | 0.7363894 | 0.00464 | ** | NA |
| KHSRP | 0.0046808 | 0.7363894 | 0.00468 | ** | NA |
| PPP1R1C | 0.0047398 | 0.7363894 | 0.00474 | ** | NA |
| CDC37 | 0.0047810 | 0.7363894 | 0.00478 | ** | NA |
| CD200R1 | 0.0048862 | 0.7363894 | 0.00489 | ** | NA |
| FOXRED1 | 0.0049144 | 0.7363894 | 0.00491 | ** | NA |
| HCRTR1 | 0.0049160 | 0.7363894 | 0.00492 | ** | NA |
| ZC3H4 | 0.0050449 | 0.7363894 | 0.00504 | ** | NA |
| RBBP9 | 0.0050826 | 0.7363894 | 0.00508 | ** | NA |
| ATXN2L | 0.0051242 | 0.7363894 | 0.00512 | ** | NA |
| OGFOD3 | 0.0051338 | 0.7363894 | 0.00513 | ** | NA |
| TBC1D22A | 0.0052429 | 0.7363894 | 0.00524 | ** | NA |
| MYO19 | 0.0052689 | 0.7363894 | 0.00527 | ** | NA |
| APOBEC1 | 0.0052779 | 0.7363894 | 0.00528 | ** | NA |
| OR56A3 | 0.0052916 | 0.7363894 | 0.00529 | ** | NA |
| SLC46A2 | 0.0053108 | 0.7363894 | 0.00531 | ** | NA |
| STK17B | 0.0053176 | 0.7363894 | 0.00532 | ** | NA |
| C6orf15 | 0.0053410 | 0.7363894 | 0.00534 | ** | NA |
| SMPD1 | 0.0053513 | 0.7363894 | 0.00535 | ** | NA |
| ANKRD31 | 0.0054062 | 0.7363894 | 0.00541 | ** | NA |
| NOL6 | 0.0054387 | 0.7363894 | 0.00544 | ** | NA |
| DNAJC5B | 0.0057016 | 0.7363894 | 0.00570 | ** | NA |
| TAS2R60 | 0.0057034 | 0.7363894 | 0.00570 | ** | NA |
| SPAG17 | 0.0057226 | 0.7363894 | 0.00572 | ** | NA |
| IBA57 | 0.0057420 | 0.7363894 | 0.00574 | ** | NA |
| HSD3B7 | 0.0057475 | 0.7363894 | 0.00575 | ** | NA |
| MBD3L2 | 0.0058844 | 0.7363894 | 0.00588 | ** | NA |
| COPS2 | 0.0059315 | 0.7363894 | 0.00593 | ** | NA |
| GRM7 | 0.0059495 | 0.7363894 | 0.00595 | ** | NA |
| NBPF15 | 0.0061326 | 0.7363894 | 0.00613 | ** | NA |
| CD5L | 0.0061772 | 0.7363894 | 0.00618 | ** | NA |
| STIL | 0.0062088 | 0.7363894 | 0.00621 | ** | NA |
| LMX1A | 0.0062097 | 0.7363894 | 0.00621 | ** | NA |
| ANTXRL | 0.0062215 | 0.7363894 | 0.00622 | ** | NA |
| MMS22L | 0.0062232 | 0.7363894 | 0.00622 | ** | NA |
| SFXN3 | 0.0062354 | 0.7363894 | 0.00624 | ** | NA |
| FAM181B | 0.0062849 | 0.7363894 | 0.00628 | ** | NA |
| SMARCB1 | 0.0062993 | 0.7363894 | 0.00630 | ** | NA |
| ACBD6 | 0.0063036 | 0.7363894 | 0.00630 | ** | NA |
| FBXL20 | 0.0064106 | 0.7363894 | 0.00641 | ** | NA |
| NXPH4 | 0.0064264 | 0.7363894 | 0.00643 | ** | NA |
| CCNB1 | 0.0065022 | 0.7363894 | 0.00650 | ** | NA |
| OR4N2 | 0.0065455 | 0.7363894 | 0.00655 | ** | NA |
| RGS12 | 0.0065563 | 0.7363894 | 0.00656 | ** | NA |
| SSH2 | 0.0065847 | 0.7363894 | 0.00658 | ** | NA |
| CEP76 | 0.0066070 | 0.7363894 | 0.00661 | ** | NA |
| MIIP | 0.0066145 | 0.7363894 | 0.00661 | ** | NA |
| FCN3 | 0.0066248 | 0.7363894 | 0.00662 | ** | NA |
| TACSTD2 | 0.0066861 | 0.7363894 | 0.00669 | ** | NA |
| TSPAN13 | 0.0067540 | 0.7363894 | 0.00675 | ** | NA |
| LPCAT4 | 0.0067758 | 0.7363894 | 0.00678 | ** | NA |
| KIF11 | 0.0068236 | 0.7363894 | 0.00682 | ** | NA |
| IFFO2 | 0.0068857 | 0.7363894 | 0.00689 | ** | NA |
| PCK2 | 0.0068961 | 0.7363894 | 0.00690 | ** | NA |
| COG3 | 0.0069083 | 0.7363894 | 0.00691 | ** | NA |
| TTF1 | 0.0069153 | 0.7363894 | 0.00692 | ** | NA |
| DHX35 | 0.0069214 | 0.7363894 | 0.00692 | ** | NA |
| LRGUK | 0.0069230 | 0.7363894 | 0.00692 | ** | NA |
| PPM1A | 0.0069353 | 0.7363894 | 0.00694 | ** | NA |
| MSGN1 | 0.0069483 | 0.7363894 | 0.00695 | ** | NA |
| CWH43 | 0.0072297 | 0.7502064 | 0.00723 | ** | NA |
| PRKCZ | 0.0072554 | 0.7502064 | 0.00726 | ** | NA |
| ACTL8 | 0.0072969 | 0.7502064 | 0.00730 | ** | NA |
| SMCR8 | 0.0073359 | 0.7502064 | 0.00734 | ** | NA |
| FBXW12 | 0.0073604 | 0.7502064 | 0.00736 | ** | NA |
| HSPB2 | 0.0073660 | 0.7502064 | 0.00737 | ** | NA |
| PTPRE | 0.0073845 | 0.7502064 | 0.00738 | ** | NA |
| ACTA1 | 0.0075292 | 0.7510110 | 0.00753 | ** | NA |
| INTS12 | 0.0075473 | 0.7510110 | 0.00755 | ** | NA |
| NAA15 | 0.0075638 | 0.7510110 | 0.00756 | ** | NA |
| ARSB | 0.0076069 | 0.7510110 | 0.00761 | ** | NA |
| VPS37B | 0.0076704 | 0.7510110 | 0.00767 | ** | NA |
| SLC30A4 | 0.0076799 | 0.7510110 | 0.00768 | ** | NA |
| ATR | 0.0076986 | 0.7510110 | 0.00770 | ** | NA |
| NCR3LG1 | 0.0078580 | 0.7605404 | 0.00786 | ** | NA |
| MTMR3 | 0.0078849 | 0.7605404 | 0.00788 | ** | NA |
| ACYP2 | 0.0079841 | 0.7606029 | 0.00798 | ** | NA |
| PLOD1 | 0.0080515 | 0.7606029 | 0.00805 | ** | NA |
| MCTP1 | 0.0082300 | 0.7606029 | 0.00823 | ** | NA |
| LILRB2 | 0.0082617 | 0.7606029 | 0.00826 | ** | NA |
| H2AFY2 | 0.0083475 | 0.7606029 | 0.00835 | ** | NA |
| MRPL13 | 0.0083762 | 0.7606029 | 0.00838 | ** | NA |
| PAQR3 | 0.0084147 | 0.7606029 | 0.00841 | ** | NA |
| GHITM | 0.0084474 | 0.7606029 | 0.00845 | ** | NA |
| FASTKD2 | 0.0085145 | 0.7606029 | 0.00851 | ** | NA |
| ADO | 0.0085378 | 0.7606029 | 0.00854 | ** | NA |
| SAMM50 | 0.0085631 | 0.7606029 | 0.00856 | ** | NA |
| MFAP4 | 0.0085654 | 0.7606029 | 0.00857 | ** | NA |
| CD163 | 0.0085663 | 0.7606029 | 0.00857 | ** | NA |
| ARMC7 | 0.0085988 | 0.7606029 | 0.00860 | ** | NA |
| COL8A1 | 0.0086043 | 0.7606029 | 0.00860 | ** | NA |
| POLG | 0.0086672 | 0.7606029 | 0.00867 | ** | NA |
| MAML2 | 0.0087207 | 0.7606029 | 0.00872 | ** | NA |
| EPS8L3 | 0.0087956 | 0.7606029 | 0.00880 | ** | NA |
| MUS81 | 0.0089063 | 0.7606029 | 0.00891 | ** | NA |
| ATAD5 | 0.0089333 | 0.7606029 | 0.00893 | ** | NA |
| C1orf141 | 0.0089498 | 0.7606029 | 0.00895 | ** | NA |
| LRP12 | 0.0090984 | 0.7606029 | 0.00910 | ** | NA |
| H3F3A | 0.0091122 | 0.7606029 | 0.00911 | ** | NA |
| COL7A1 | 0.0091404 | 0.7606029 | 0.00914 | ** | NA |
| TMEM258 | 0.0091769 | 0.7606029 | 0.00918 | ** | NA |
| DNAJC8 | 0.0093058 | 0.7606029 | 0.00931 | ** | NA |
| MTSS1L | 0.0093383 | 0.7606029 | 0.00934 | ** | NA |
| KRTAP4-4 | 0.0093494 | 0.7606029 | 0.00935 | ** | NA |
| SGK2 | 0.0093988 | 0.7606029 | 0.00940 | ** | NA |
| PI4K2A | 0.0094006 | 0.7606029 | 0.00940 | ** | NA |
| SLC12A4 | 0.0094201 | 0.7606029 | 0.00942 | ** | NA |
| SLC25A4 | 0.0094344 | 0.7606029 | 0.00943 | ** | NA |
| F11R | 0.0094708 | 0.7606029 | 0.00947 | ** | NA |
| LY6G6F | 0.0095144 | 0.7606029 | 0.00951 | ** | NA |
| ZNF330 | 0.0095171 | 0.7606029 | 0.00952 | ** | NA |
| NECAB1 | 0.0095689 | 0.7606029 | 0.00957 | ** | NA |
| GMCL1 | 0.0096195 | 0.7606029 | 0.00962 | ** | NA |
| C16orf58 | 0.0096729 | 0.7606029 | 0.00967 | ** | NA |
| ZBTB44 | 0.0096904 | 0.7606029 | 0.00969 | ** | NA |
| UTP20 | 0.0097175 | 0.7606029 | 0.00972 | ** | NA |
| INHBA | 0.0097282 | 0.7606029 | 0.00973 | ** | NA |
| ZDHHC24 | 0.0097462 | 0.7606029 | 0.00975 | ** | NA |
| COPS3 | 0.0098996 | 0.7690802 | 0.00990 | ** | NA |
| WDR77 | 0.0099778 | 0.7690920 | 0.00998 | ** | NA |
wilcox_gene_nonsilent_plot <- ggplot(data = crispr_signif_nonsilent) +
geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_nonsilent_plot
crispr_signif_nonsilent_lineage <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_nonsilent_lineage <- adj_signif(crispr_signif_nonsilent_lineage)
crispr_signif_nonsilent_lineage <- crispr_signif_nonsilent_lineage[order(crispr_signif_nonsilent_lineage$p),]
saveRDS(crispr_signif_nonsilent_lineage, "./data_munging/rds/crispr_signif_ptmuts_nonsilent_lineage.rds")
# write.table(crispr_signif_nonsilent_lineage, file = "~/Desktop/crispr_signif_ptmuts_nonsilent_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_nonsilent_lineage <- readRDS("./data_munging/rds/crispr_signif_ptmuts_nonsilent_lineage.rds")
knitr::kable(filter(crispr_signif_nonsilent_lineage, p < 0.01)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant vs other cell lines by lineage, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
wilcox_lineage_nonsilent_plot <- ggplot(data = crispr_signif_nonsilent_lineage) +
geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_lineage_nonsilent_plot
crispr_data_lvlA <- filter(crispr_data_ptmuts, Hugo_Symbol %in% genes_lvlA)
crispr_data_lvlA_summ <- unique(crispr_data_lvlA[, c("Hugo_Symbol", "N_Nonsilent_Mutant", "N_Nonsilent_Other")])
crispr_data_lvlA_summ$Fraction_Mutant <- crispr_data_lvlA_summ$N_Nonsilent_Mutant / (crispr_data_lvlA_summ$N_Nonsilent_Mutant + crispr_data_lvlA_summ$N_Nonsilent_Other)
crispr_data_lvlA_summ$Percent_Mutant <- crispr_data_lvlA_summ$Fraction_Mutant * 100
# write.table(crispr_data_lvlA_summ, file = "~/Desktop/crispr_data_lvlA_summ_20181003.tsv", quote = FALSE, sep = "\t")
crispr_signif_lvlA <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol"), data = crispr_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_lvlA <- adj_signif(crispr_signif_lvlA)
crispr_signif_lvlA <- crispr_signif_lvlA[order(crispr_signif_lvlA$p),]
saveRDS(crispr_signif_lvlA, "./data_munging/rds/crispr_signif_lvlA_gene.rds")
crispr_signif_lvlA <- readRDS("./data_munging/rds/crispr_signif_lvlA_gene.rds")
crispr_signif_genes_lvlA <- as.character(crispr_signif_lvlA$Hugo_Symbol[0:20])
knitr::kable(filter(crispr_signif_lvlA, p < 0.1)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|
| KRAS | 0.0000000 | 0.0000000 | < 2e-16 | **** | **** |
| TP53 | 0.0000000 | 0.0000000 | < 2e-16 | **** | **** |
| NRAS | 0.0000000 | 0.0000000 | < 2e-16 | **** | **** |
| BRAF | 0.0000000 | 0.0000000 | < 2e-16 | **** | **** |
| PIK3CA | 0.0000000 | 0.0000000 | 1.5e-14 | **** | **** |
| PTEN | 0.0000000 | 0.0000000 | 2.3e-14 | **** | **** |
| CTNNB1 | 0.0000050 | 0.0000833 | 5.0e-06 | **** | **** |
| FBXW7 | 0.0007199 | 0.0105284 | 0.00072 | *** |
|
| HRAS | 0.0008408 | 0.0109309 | 0.00084 | *** |
|
| EZH2 | 0.0022431 | 0.0262441 | 0.00224 | ** |
|
| VHL | 0.0027587 | 0.0293428 | 0.00276 | ** |
|
| TSC2 | 0.0123492 | 0.1204049 | 0.01235 |
|
NA |
| JAK2 | 0.0164691 | 0.1450340 | 0.01647 |
|
NA |
| UGT1A1 | 0.0173545 | 0.1450340 | 0.01735 |
|
NA |
| CDKN2A | 0.0251833 | 0.1833015 | 0.02518 |
|
NA |
| WHSC1 | 0.0261222 | 0.1833015 | 0.02612 |
|
NA |
| CYP19A1 | 0.0266336 | 0.1833015 | 0.02663 |
|
NA |
| ATM | 0.0319423 | 0.2076249 | 0.03194 |
|
NA |
| DPYD | 0.0395906 | 0.2437946 | 0.03959 |
|
NA |
| CREBBP | 0.0427407 | 0.2500332 | 0.04274 |
|
NA |
| IDH1 | 0.0565836 | 0.3152514 | 0.05658 | NA | NA |
| NOTCH2 | 0.0773788 | 0.4115146 | 0.07738 | NA | NA |
| CALR | 0.0829167 | 0.4217939 | 0.08292 | NA | NA |
| SRSF2 | 0.0906149 | 0.4417474 | 0.09061 | NA | NA |
| GATA2 | 0.0979336 | 0.4583294 | 0.09793 | NA | NA |
wilcox_gene_lvlA_plot <- ggplot(data = crispr_signif_lvlA) +
geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_lvlA_plot
lvlA_genes_signif <- filter(crispr_data_ptmuts, Hugo_Symbol %in% crispr_signif_genes_lvlA)
lvlA_genes_signif <- merge(lvlA_genes_signif, crispr_signif_lvlA, by = "Hugo_Symbol")
lvlA_genes_signif$Hugo_Symbol <- ordered(lvlA_genes_signif$Hugo_Symbol, levels = crispr_signif_genes_lvlA)
lvlA_genes_signif_color <- as.character(lvlA_genes_signif$Color_Nonsilent)
names(lvlA_genes_signif_color) <- lvlA_genes_signif$Mutation_Status_Nonsilent
lvlA_genes_signif <- merge(lvlA_genes_signif, lvlA_genes_signif %>% group_by(Hugo_Symbol) %>% summarize(Text_y = max(Score)), by = "Hugo_Symbol")
lvlA_genes_text <- unique(data.frame(p.signif.adj = lvlA_genes_signif$p.signif.adj, Hugo_Symbol = lvlA_genes_signif$Hugo_Symbol, Text_y = lvlA_genes_signif$Text_y))
lvlA_genes_text$Hugo_Symbol <- factor(lvlA_genes_text$Hugo_Symbol, levels = crispr_signif_genes_lvlA)
lvlA_signif_genes_plot <- ggplot(data = lvlA_genes_signif, aes(x = Mutation_Status_Nonsilent, y = Score)) +
facet_wrap(~ Hugo_Symbol, nrow = 2, scales = "free_y") +
geom_jitter(aes(color = Mutation_Status_Nonsilent), alpha = 0.5, width = 0.3) +
geom_boxplot(color = "black", fill = NA, outlier.shape = NA) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
scale_color_manual(values = lvlA_genes_signif_color) +
geom_text(data = lvlA_genes_text, mapping = aes(x = 1.5, y = Text_y, label = p.signif.adj), nudge_y = 0.2) +
theme(legend.position = "top") +
labs(y = "CERES Score",
x = "Lineage",
color = "Mutation Status",
title = "CERES scores for select Level A G2P genes",
subtitle = "Genes with adjusted p-values < 0.3 are shown.\nBH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001\nGenes are sorted by increasing p-value.")
lvlA_signif_genes_plot
# ggsave("./plots_18Q3/manuscript/crispr_g2p_lvlA_signif_genes_plot.png", lvlA_signif_genes_plot, width = 12, height = 7, units = "in")
crispr_signif_lvlA_lineage <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_lvlA_lineage <- adj_signif(crispr_signif_lvlA_lineage)
crispr_signif_lvlA_lineage <- crispr_signif_lvlA_lineage[order(crispr_signif_lvlA_lineage$p),]
saveRDS(crispr_signif_lvlA_lineage, "./data_munging/rds/crispr_signif_lvlA_lineage.rds")
# write.table(crispr_signif_lvlA_lineage, file = "~/Desktop/crispr_signif_lvlA_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_lvlA_lineage <- readRDS("./data_munging/rds/crispr_signif_lvlA_lineage.rds")
knitr::kable(filter(crispr_signif_lvlA_lineage, p < 0.01)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant vs other cell lines by lineage, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | group_general_lineage_name | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| KRAS | lung cancer | 0.0000000 | 0.0000030 | 2.5e-09 | **** | **** |
| TP53 | lung cancer | 0.0000086 | 0.0049934 | 8.6e-06 | **** | ** |
| TP53 | central nervous system cancer | 0.0000504 | 0.0195615 | 5.0e-05 | **** |
|
| KRAS | ovarian cancer | 0.0001488 | 0.0433268 | 0.00015 | *** |
|
| TP53 | ovarian cancer | 0.0002837 | 0.0661128 | 0.00028 | *** | NA |
| NRAS | leukemia | 0.0005316 | 0.1032138 | 0.00053 | *** | NA |
| PIK3CA | ovarian cancer | 0.0008371 | 0.1365241 | 0.00084 | *** | NA |
| PIK3CA | breast cancer | 0.0009842 | 0.1365241 | 0.00098 | *** | NA |
| KRAS | colorectal cancer | 0.0010547 | 0.1365241 | 0.00105 | ** | NA |
| NRAS | multiple myeloma | 0.0013756 | 0.1602564 | 0.00138 | ** | NA |
| NRAS | skin cancer | 0.0016637 | 0.1762022 | 0.00166 | ** | NA |
| TP53 | leukemia | 0.0023741 | 0.2304810 | 0.00237 | ** | NA |
| PTEN | ovarian cancer | 0.0032141 | 0.2733311 | 0.00321 | ** | NA |
| TP53 | colorectal cancer | 0.0036603 | 0.2733311 | 0.00366 | ** | NA |
| TP53 | skin cancer | 0.0037227 | 0.2733311 | 0.00372 | ** | NA |
| VHL | kidney cancer | 0.0037539 | 0.2733311 | 0.00375 | ** | NA |
| KRAS | stomach cancer | 0.0040001 | 0.2741275 | 0.00400 | ** | NA |
| BRAF | skin cancer | 0.0054870 | 0.3419998 | 0.00549 | ** | NA |
| SETD2 | kidney cancer | 0.0056647 | 0.3419998 | 0.00566 | ** | NA |
| PTEN | central nervous system cancer | 0.0059869 | 0.3419998 | 0.00599 | ** | NA |
| ASXL1 | colorectal cancer | 0.0061648 | 0.3419998 | 0.00616 | ** | NA |
| PIK3CA | colorectal cancer | 0.0070506 | 0.3733617 | 0.00705 | ** | NA |
| PTEN | uterine cancer | 0.0080389 | 0.4071865 | 0.00804 | ** | NA |
wilcox_lineage_lvlA_plot <- ggplot(data = crispr_signif_lvlA_lineage) +
geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_lineage_lvlA_plot
lvlA_signif <- filter(crispr_data_ptmuts, Hugo_Symbol %in% crispr_signif_genes_lvlA)
lvlA_signif <- merge(lvlA_signif, crispr_signif_lvlA_lineage, by = c("Hugo_Symbol", "group_general_lineage_name"))
lvlA_signif$Hugo_Symbol <- ordered(lvlA_signif$Hugo_Symbol, levels = crispr_signif_genes_lvlA)
lvlA_signif_color <- as.character(lvlA_signif$Color_Nonsilent)
names(lvlA_signif_color) <- lvlA_signif$Mutation_Status_Nonsilent
lvlA_signif <- merge(lvlA_signif, lvlA_signif %>% group_by(Hugo_Symbol) %>% summarize(Text_y = max(Score)), by = "Hugo_Symbol")
lvlA_text <- unique(data.frame(p.signif.adj = lvlA_signif$p.signif.adj, group_general_lineage_name = lvlA_signif$group_general_lineage_name, Hugo_Symbol = lvlA_signif$Hugo_Symbol, Text_y = lvlA_signif$Text_y))
lvlA_text$Hugo_Symbol <- factor(lvlA_text$Hugo_Symbol, levels = crispr_signif_genes_lvlA)
lvlA_signif_lineages_plot <- ggplot(data = lvlA_signif, aes(x = group_general_lineage_name, y = Score)) +
facet_wrap(~ Hugo_Symbol, nrow = 4, scales = "free_y") +
geom_point(aes(color = Mutation_Status_Nonsilent), alpha = 0.5) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
scale_color_manual(values = lvlA_signif_color) +
geom_text(data = lvlA_text, mapping = aes(x = group_general_lineage_name, y = Text_y, label = p.signif.adj), nudge_y = 0.1) +
theme(legend.position = "top", axis.text.x = element_text(angle = 90, hjust = 1, vjust = 1, size = 10)) +
labs(y = "CERES Score",
x = "Lineage",
color = "Mutation Status",
title = "CERES score by cell line lineage for significant Level A G2P genes",
subtitle = "Genes with adjusted p-values < 0.3 are shown.\nBH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001\nGenes are sorted by increasing lineage-agnostic p-value.")
lvlA_signif_lineages_plot
# ggsave("./plots_18Q3/manuscript/crispr_g2p_lvlA_signif_lineages_plot.png", lvlA_signif_lineages_plot, width = 12, height = 15, units = "in")
lvlA_signif_summ <- lvlA_signif %>% group_by(Hugo_Symbol, group_general_lineage_name, Mutation_Status_Nonsilent) %>% tally()
# write.table(lvlA_signif_summ, file = "~/Desktop/lvlA_signif_summ_20181005.tsv", quote = FALSE, sep = "\t")
knitr::kable(lvlA_signif_summ, caption = "Mutant/Other counts for gene-lineage combinations") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | group_general_lineage_name | Mutation_Status_Nonsilent | n |
|---|---|---|---|
| KRAS | bone cancer | Mutant | 1 |
| KRAS | bone cancer | Other | 15 |
| KRAS | breast cancer | Mutant | 2 |
| KRAS | breast cancer | Other | 24 |
| KRAS | colorectal cancer | Mutant | 14 |
| KRAS | colorectal cancer | Other | 13 |
| KRAS | esophageal cancer | Mutant | 1 |
| KRAS | esophageal cancer | Other | 13 |
| KRAS | leukemia | Mutant | 2 |
| KRAS | leukemia | Other | 19 |
| KRAS | lung cancer | Mutant | 22 |
| KRAS | lung cancer | Other | 48 |
| KRAS | multiple myeloma | Mutant | 4 |
| KRAS | multiple myeloma | Other | 12 |
| KRAS | ovarian cancer | Mutant | 9 |
| KRAS | ovarian cancer | Other | 26 |
| KRAS | pancreatic cancer | Mutant | 23 |
| KRAS | pancreatic cancer | Other | 1 |
| KRAS | stomach cancer | Mutant | 5 |
| KRAS | stomach cancer | Other | 10 |
| KRAS | urinary bladder cancer | Mutant | 2 |
| KRAS | urinary bladder cancer | Other | 19 |
| KRAS | uterine cancer | Mutant | 7 |
| KRAS | uterine cancer | Other | 11 |
| TP53 | bone cancer | Mutant | 8 |
| TP53 | bone cancer | Other | 7 |
| TP53 | breast cancer | Mutant | 16 |
| TP53 | breast cancer | Other | 6 |
| TP53 | cancer | Mutant | 7 |
| TP53 | cancer | Other | 10 |
| TP53 | central nervous system cancer | Mutant | 29 |
| TP53 | central nervous system cancer | Other | 13 |
| TP53 | colorectal cancer | Mutant | 18 |
| TP53 | colorectal cancer | Other | 9 |
| TP53 | head and neck cancer | Mutant | 11 |
| TP53 | head and neck cancer | Other | 1 |
| TP53 | kidney cancer | Mutant | 7 |
| TP53 | kidney cancer | Other | 14 |
| TP53 | leukemia | Mutant | 11 |
| TP53 | leukemia | Other | 9 |
| TP53 | liver cancer | Mutant | 10 |
| TP53 | liver cancer | Other | 4 |
| TP53 | lung cancer | Mutant | 53 |
| TP53 | lung cancer | Other | 16 |
| TP53 | lymphoma | Mutant | 7 |
| TP53 | lymphoma | Other | 4 |
| TP53 | malignant mesothelioma | Mutant | 1 |
| TP53 | malignant mesothelioma | Other | 1 |
| TP53 | multiple myeloma | Mutant | 12 |
| TP53 | multiple myeloma | Other | 4 |
| TP53 | ovarian cancer | Mutant | 19 |
| TP53 | ovarian cancer | Other | 12 |
| TP53 | pancreatic cancer | Mutant | 19 |
| TP53 | pancreatic cancer | Other | 3 |
| TP53 | peripheral nervous system neoplasm | Mutant | 4 |
| TP53 | peripheral nervous system neoplasm | Other | 9 |
| TP53 | rhabdomyosarcoma | Mutant | 4 |
| TP53 | rhabdomyosarcoma | Other | 3 |
| TP53 | skin cancer | Mutant | 10 |
| TP53 | skin cancer | Other | 18 |
| TP53 | stomach cancer | Mutant | 13 |
| TP53 | stomach cancer | Other | 2 |
| TP53 | urinary bladder cancer | Mutant | 17 |
| TP53 | urinary bladder cancer | Other | 4 |
| TP53 | uterine cancer | Mutant | 14 |
| TP53 | uterine cancer | Other | 5 |
| NRAS | bone cancer | Mutant | 1 |
| NRAS | bone cancer | Other | 15 |
| NRAS | cancer | Mutant | 2 |
| NRAS | cancer | Other | 16 |
| NRAS | central nervous system cancer | Mutant | 2 |
| NRAS | central nervous system cancer | Other | 43 |
| NRAS | head and neck cancer | Mutant | 1 |
| NRAS | head and neck cancer | Other | 14 |
| NRAS | leukemia | Mutant | 6 |
| NRAS | leukemia | Other | 15 |
| NRAS | lung cancer | Mutant | 5 |
| NRAS | lung cancer | Other | 65 |
| NRAS | lymphoma | Mutant | 2 |
| NRAS | lymphoma | Other | 9 |
| NRAS | multiple myeloma | Mutant | 6 |
| NRAS | multiple myeloma | Other | 10 |
| NRAS | peripheral nervous system neoplasm | Mutant | 2 |
| NRAS | peripheral nervous system neoplasm | Other | 11 |
| NRAS | rhabdomyosarcoma | Mutant | 1 |
| NRAS | rhabdomyosarcoma | Other | 6 |
| NRAS | skin cancer | Mutant | 5 |
| NRAS | skin cancer | Other | 25 |
| NRAS | urinary bladder cancer | Mutant | 4 |
| NRAS | urinary bladder cancer | Other | 17 |
| NRAS | uterine cancer | Mutant | 3 |
| NRAS | uterine cancer | Other | 15 |
| BRAF | bone cancer | Mutant | 1 |
| BRAF | bone cancer | Other | 14 |
| BRAF | breast cancer | Mutant | 3 |
| BRAF | breast cancer | Other | 22 |
| BRAF | cancer | Mutant | 2 |
| BRAF | cancer | Other | 16 |
| BRAF | central nervous system cancer | Mutant | 2 |
| BRAF | central nervous system cancer | Other | 43 |
| BRAF | colorectal cancer | Mutant | 13 |
| BRAF | colorectal cancer | Other | 15 |
| BRAF | esophageal cancer | Mutant | 2 |
| BRAF | esophageal cancer | Other | 12 |
| BRAF | liver cancer | Mutant | 1 |
| BRAF | liver cancer | Other | 15 |
| BRAF | lung cancer | Mutant | 3 |
| BRAF | lung cancer | Other | 66 |
| BRAF | multiple myeloma | Mutant | 2 |
| BRAF | multiple myeloma | Other | 14 |
| BRAF | ovarian cancer | Mutant | 3 |
| BRAF | ovarian cancer | Other | 31 |
| BRAF | pancreatic cancer | Mutant | 2 |
| BRAF | pancreatic cancer | Other | 21 |
| BRAF | peripheral nervous system neoplasm | Mutant | 1 |
| BRAF | peripheral nervous system neoplasm | Other | 12 |
| BRAF | skin cancer | Mutant | 23 |
| BRAF | skin cancer | Other | 8 |
| BRAF | stomach cancer | Mutant | 1 |
| BRAF | stomach cancer | Other | 14 |
| BRAF | thyroid cancer | Mutant | 1 |
| BRAF | thyroid cancer | Other | 2 |
| BRAF | urinary bladder cancer | Mutant | 1 |
| BRAF | urinary bladder cancer | Other | 20 |
| BRAF | uterine cancer | Mutant | 5 |
| BRAF | uterine cancer | Other | 14 |
| PIK3CA | breast cancer | Mutant | 7 |
| PIK3CA | breast cancer | Other | 19 |
| PIK3CA | cancer | Mutant | 1 |
| PIK3CA | cancer | Other | 17 |
| PIK3CA | central nervous system cancer | Mutant | 3 |
| PIK3CA | central nervous system cancer | Other | 42 |
| PIK3CA | cervical cancer | Mutant | 1 |
| PIK3CA | cervical cancer | Other | 1 |
| PIK3CA | colorectal cancer | Mutant | 8 |
| PIK3CA | colorectal cancer | Other | 18 |
| PIK3CA | esophageal cancer | Mutant | 3 |
| PIK3CA | esophageal cancer | Other | 11 |
| PIK3CA | head and neck cancer | Mutant | 3 |
| PIK3CA | head and neck cancer | Other | 12 |
| PIK3CA | kidney cancer | Mutant | 1 |
| PIK3CA | kidney cancer | Other | 21 |
| PIK3CA | leukemia | Mutant | 1 |
| PIK3CA | leukemia | Other | 20 |
| PIK3CA | lung cancer | Mutant | 4 |
| PIK3CA | lung cancer | Other | 65 |
| PIK3CA | lymphoma | Mutant | 1 |
| PIK3CA | lymphoma | Other | 10 |
| PIK3CA | multiple myeloma | Mutant | 1 |
| PIK3CA | multiple myeloma | Other | 15 |
| PIK3CA | ovarian cancer | Mutant | 9 |
| PIK3CA | ovarian cancer | Other | 26 |
| PIK3CA | stomach cancer | Mutant | 3 |
| PIK3CA | stomach cancer | Other | 12 |
| PIK3CA | urinary bladder cancer | Mutant | 8 |
| PIK3CA | urinary bladder cancer | Other | 14 |
| PIK3CA | uterine cancer | Mutant | 12 |
| PIK3CA | uterine cancer | Other | 8 |
| PTEN | breast cancer | Mutant | 8 |
| PTEN | breast cancer | Other | 19 |
| PTEN | cancer | Mutant | 1 |
| PTEN | cancer | Other | 17 |
| PTEN | central nervous system cancer | Mutant | 19 |
| PTEN | central nervous system cancer | Other | 25 |
| PTEN | colorectal cancer | Mutant | 3 |
| PTEN | colorectal cancer | Other | 24 |
| PTEN | esophageal cancer | Mutant | 1 |
| PTEN | esophageal cancer | Other | 13 |
| PTEN | head and neck cancer | Mutant | 1 |
| PTEN | head and neck cancer | Other | 14 |
| PTEN | kidney cancer | Mutant | 3 |
| PTEN | kidney cancer | Other | 19 |
| PTEN | leukemia | Mutant | 4 |
| PTEN | leukemia | Other | 17 |
| PTEN | liver cancer | Mutant | 1 |
| PTEN | liver cancer | Other | 15 |
| PTEN | lung cancer | Mutant | 6 |
| PTEN | lung cancer | Other | 63 |
| PTEN | lymphoma | Mutant | 1 |
| PTEN | lymphoma | Other | 10 |
| PTEN | ovarian cancer | Mutant | 5 |
| PTEN | ovarian cancer | Other | 30 |
| PTEN | skin cancer | Mutant | 5 |
| PTEN | skin cancer | Other | 24 |
| PTEN | stomach cancer | Mutant | 1 |
| PTEN | stomach cancer | Other | 14 |
| PTEN | urinary bladder cancer | Mutant | 2 |
| PTEN | urinary bladder cancer | Other | 19 |
| PTEN | uterine cancer | Mutant | 9 |
| PTEN | uterine cancer | Other | 9 |
| CTNNB1 | bone cancer | Mutant | 1 |
| CTNNB1 | bone cancer | Other | 15 |
| CTNNB1 | cancer | Mutant | 1 |
| CTNNB1 | cancer | Other | 16 |
| CTNNB1 | central nervous system cancer | Mutant | 1 |
| CTNNB1 | central nervous system cancer | Other | 44 |
| CTNNB1 | colorectal cancer | Mutant | 6 |
| CTNNB1 | colorectal cancer | Other | 22 |
| CTNNB1 | head and neck cancer | Mutant | 1 |
| CTNNB1 | head and neck cancer | Other | 15 |
| CTNNB1 | leukemia | Mutant | 2 |
| CTNNB1 | leukemia | Other | 19 |
| CTNNB1 | liver cancer | Mutant | 2 |
| CTNNB1 | liver cancer | Other | 14 |
| CTNNB1 | lung cancer | Mutant | 5 |
| CTNNB1 | lung cancer | Other | 64 |
| CTNNB1 | multiple myeloma | Mutant | 1 |
| CTNNB1 | multiple myeloma | Other | 15 |
| CTNNB1 | ovarian cancer | Mutant | 2 |
| CTNNB1 | ovarian cancer | Other | 33 |
| CTNNB1 | skin cancer | Mutant | 1 |
| CTNNB1 | skin cancer | Other | 28 |
| CTNNB1 | stomach cancer | Mutant | 2 |
| CTNNB1 | stomach cancer | Other | 13 |
| CTNNB1 | urinary bladder cancer | Mutant | 1 |
| CTNNB1 | urinary bladder cancer | Other | 20 |
| CTNNB1 | uterine cancer | Mutant | 4 |
| CTNNB1 | uterine cancer | Other | 15 |
| FBXW7 | breast cancer | Mutant | 1 |
| FBXW7 | breast cancer | Other | 25 |
| FBXW7 | colorectal cancer | Mutant | 6 |
| FBXW7 | colorectal cancer | Other | 23 |
| FBXW7 | head and neck cancer | Mutant | 1 |
| FBXW7 | head and neck cancer | Other | 14 |
| FBXW7 | kidney cancer | Mutant | 1 |
| FBXW7 | kidney cancer | Other | 19 |
| FBXW7 | leukemia | Mutant | 1 |
| FBXW7 | leukemia | Other | 20 |
| FBXW7 | lung cancer | Mutant | 6 |
| FBXW7 | lung cancer | Other | 64 |
| FBXW7 | lymphoma | Mutant | 2 |
| FBXW7 | lymphoma | Other | 9 |
| FBXW7 | ovarian cancer | Mutant | 2 |
| FBXW7 | ovarian cancer | Other | 33 |
| FBXW7 | pancreatic cancer | Mutant | 1 |
| FBXW7 | pancreatic cancer | Other | 22 |
| FBXW7 | peripheral nervous system neoplasm | Mutant | 1 |
| FBXW7 | peripheral nervous system neoplasm | Other | 12 |
| FBXW7 | skin cancer | Mutant | 1 |
| FBXW7 | skin cancer | Other | 28 |
| FBXW7 | stomach cancer | Mutant | 1 |
| FBXW7 | stomach cancer | Other | 14 |
| FBXW7 | urinary bladder cancer | Mutant | 1 |
| FBXW7 | urinary bladder cancer | Other | 20 |
| FBXW7 | uterine cancer | Mutant | 9 |
| FBXW7 | uterine cancer | Other | 11 |
| HRAS | breast cancer | Mutant | 3 |
| HRAS | breast cancer | Other | 23 |
| HRAS | esophageal cancer | Mutant | 1 |
| HRAS | esophageal cancer | Other | 13 |
| HRAS | kidney cancer | Mutant | 1 |
| HRAS | kidney cancer | Other | 21 |
| HRAS | lung cancer | Mutant | 1 |
| HRAS | lung cancer | Other | 68 |
| HRAS | skin cancer | Mutant | 2 |
| HRAS | skin cancer | Other | 27 |
| HRAS | urinary bladder cancer | Mutant | 1 |
| HRAS | urinary bladder cancer | Other | 20 |
| HRAS | uterine cancer | Mutant | 1 |
| HRAS | uterine cancer | Other | 17 |
| EZH2 | breast cancer | Mutant | 1 |
| EZH2 | breast cancer | Other | 25 |
| EZH2 | cancer | Mutant | 1 |
| EZH2 | cancer | Other | 17 |
| EZH2 | colorectal cancer | Mutant | 3 |
| EZH2 | colorectal cancer | Other | 24 |
| EZH2 | leukemia | Mutant | 1 |
| EZH2 | leukemia | Other | 20 |
| EZH2 | lung cancer | Mutant | 2 |
| EZH2 | lung cancer | Other | 67 |
| EZH2 | lymphoma | Mutant | 3 |
| EZH2 | lymphoma | Other | 8 |
| EZH2 | multiple myeloma | Mutant | 1 |
| EZH2 | multiple myeloma | Other | 15 |
| EZH2 | pancreatic cancer | Mutant | 1 |
| EZH2 | pancreatic cancer | Other | 22 |
| EZH2 | skin cancer | Mutant | 3 |
| EZH2 | skin cancer | Other | 26 |
| EZH2 | urinary bladder cancer | Mutant | 1 |
| EZH2 | urinary bladder cancer | Other | 20 |
| EZH2 | uterine cancer | Mutant | 2 |
| EZH2 | uterine cancer | Other | 17 |
| VHL | breast cancer | Mutant | 1 |
| VHL | breast cancer | Other | 25 |
| VHL | cancer | Mutant | 1 |
| VHL | cancer | Other | 17 |
| VHL | kidney cancer | Mutant | 11 |
| VHL | kidney cancer | Other | 7 |
| VHL | lung cancer | Mutant | 2 |
| VHL | lung cancer | Other | 68 |
| VHL | uterine cancer | Mutant | 2 |
| VHL | uterine cancer | Other | 16 |
| TSC2 | breast cancer | Mutant | 1 |
| TSC2 | breast cancer | Other | 25 |
| TSC2 | cancer | Mutant | 1 |
| TSC2 | cancer | Other | 17 |
| TSC2 | central nervous system cancer | Mutant | 1 |
| TSC2 | central nervous system cancer | Other | 43 |
| TSC2 | colorectal cancer | Mutant | 5 |
| TSC2 | colorectal cancer | Other | 22 |
| TSC2 | esophageal cancer | Mutant | 1 |
| TSC2 | esophageal cancer | Other | 13 |
| TSC2 | kidney cancer | Mutant | 1 |
| TSC2 | kidney cancer | Other | 21 |
| TSC2 | leukemia | Mutant | 2 |
| TSC2 | leukemia | Other | 19 |
| TSC2 | liver cancer | Mutant | 2 |
| TSC2 | liver cancer | Other | 14 |
| TSC2 | lymphoma | Mutant | 2 |
| TSC2 | lymphoma | Other | 9 |
| TSC2 | multiple myeloma | Mutant | 2 |
| TSC2 | multiple myeloma | Other | 14 |
| TSC2 | pancreatic cancer | Mutant | 2 |
| TSC2 | pancreatic cancer | Other | 21 |
| TSC2 | peripheral nervous system neoplasm | Mutant | 1 |
| TSC2 | peripheral nervous system neoplasm | Other | 12 |
| TSC2 | rhabdomyosarcoma | Mutant | 1 |
| TSC2 | rhabdomyosarcoma | Other | 6 |
| TSC2 | stomach cancer | Mutant | 2 |
| TSC2 | stomach cancer | Other | 13 |
| TSC2 | uterine cancer | Mutant | 9 |
| TSC2 | uterine cancer | Other | 10 |
| JAK2 | colorectal cancer | Mutant | 1 |
| JAK2 | colorectal cancer | Other | 27 |
| JAK2 | esophageal cancer | Mutant | 1 |
| JAK2 | esophageal cancer | Other | 13 |
| JAK2 | leukemia | Mutant | 1 |
| JAK2 | leukemia | Other | 20 |
| JAK2 | lung cancer | Mutant | 2 |
| JAK2 | lung cancer | Other | 67 |
| JAK2 | lymphoma | Mutant | 1 |
| JAK2 | lymphoma | Other | 10 |
| JAK2 | ovarian cancer | Mutant | 1 |
| JAK2 | ovarian cancer | Other | 34 |
| JAK2 | urinary bladder cancer | Mutant | 2 |
| JAK2 | urinary bladder cancer | Other | 19 |
| JAK2 | uterine cancer | Mutant | 5 |
| JAK2 | uterine cancer | Other | 13 |
| UGT1A1 | bone cancer | Mutant | 2 |
| UGT1A1 | bone cancer | Other | 14 |
| UGT1A1 | colorectal cancer | Mutant | 1 |
| UGT1A1 | colorectal cancer | Other | 25 |
| UGT1A1 | esophageal cancer | Mutant | 1 |
| UGT1A1 | esophageal cancer | Other | 13 |
| UGT1A1 | kidney cancer | Mutant | 1 |
| UGT1A1 | kidney cancer | Other | 21 |
| UGT1A1 | lung cancer | Mutant | 2 |
| UGT1A1 | lung cancer | Other | 67 |
| UGT1A1 | skin cancer | Mutant | 2 |
| UGT1A1 | skin cancer | Other | 28 |
| UGT1A1 | stomach cancer | Mutant | 1 |
| UGT1A1 | stomach cancer | Other | 14 |
| UGT1A1 | uterine cancer | Mutant | 3 |
| UGT1A1 | uterine cancer | Other | 16 |
| CDKN2A | cancer | Mutant | 2 |
| CDKN2A | cancer | Other | 17 |
| CDKN2A | colorectal cancer | Mutant | 2 |
| CDKN2A | colorectal cancer | Other | 25 |
| CDKN2A | esophageal cancer | Mutant | 2 |
| CDKN2A | esophageal cancer | Other | 12 |
| CDKN2A | head and neck cancer | Mutant | 6 |
| CDKN2A | head and neck cancer | Other | 9 |
| CDKN2A | leukemia | Mutant | 1 |
| CDKN2A | leukemia | Other | 20 |
| CDKN2A | liver cancer | Mutant | 1 |
| CDKN2A | liver cancer | Other | 15 |
| CDKN2A | lung cancer | Mutant | 11 |
| CDKN2A | lung cancer | Other | 59 |
| CDKN2A | lymphoma | Mutant | 1 |
| CDKN2A | lymphoma | Other | 10 |
| CDKN2A | multiple myeloma | Mutant | 1 |
| CDKN2A | multiple myeloma | Other | 15 |
| CDKN2A | ovarian cancer | Mutant | 4 |
| CDKN2A | ovarian cancer | Other | 31 |
| CDKN2A | pancreatic cancer | Mutant | 5 |
| CDKN2A | pancreatic cancer | Other | 17 |
| CDKN2A | peripheral nervous system neoplasm | Mutant | 1 |
| CDKN2A | peripheral nervous system neoplasm | Other | 12 |
| CDKN2A | rhabdomyosarcoma | Mutant | 3 |
| CDKN2A | rhabdomyosarcoma | Other | 4 |
| CDKN2A | skin cancer | Mutant | 9 |
| CDKN2A | skin cancer | Other | 21 |
| CDKN2A | stomach cancer | Mutant | 1 |
| CDKN2A | stomach cancer | Other | 14 |
| CDKN2A | thyroid cancer | Mutant | 1 |
| CDKN2A | thyroid cancer | Other | 3 |
| CDKN2A | urinary bladder cancer | Mutant | 2 |
| CDKN2A | urinary bladder cancer | Other | 18 |
| CDKN2A | uterine cancer | Mutant | 3 |
| CDKN2A | uterine cancer | Other | 17 |
| WHSC1 | bone cancer | Mutant | 1 |
| WHSC1 | bone cancer | Other | 15 |
| WHSC1 | cancer | Mutant | 1 |
| WHSC1 | cancer | Other | 17 |
| WHSC1 | colorectal cancer | Mutant | 6 |
| WHSC1 | colorectal cancer | Other | 21 |
| WHSC1 | leukemia | Mutant | 2 |
| WHSC1 | leukemia | Other | 19 |
| WHSC1 | lung cancer | Mutant | 2 |
| WHSC1 | lung cancer | Other | 67 |
| WHSC1 | lymphoma | Mutant | 1 |
| WHSC1 | lymphoma | Other | 10 |
| WHSC1 | multiple myeloma | Mutant | 1 |
| WHSC1 | multiple myeloma | Other | 15 |
| WHSC1 | pancreatic cancer | Mutant | 1 |
| WHSC1 | pancreatic cancer | Other | 22 |
| WHSC1 | skin cancer | Mutant | 3 |
| WHSC1 | skin cancer | Other | 26 |
| WHSC1 | thyroid cancer | Mutant | 1 |
| WHSC1 | thyroid cancer | Other | 2 |
| WHSC1 | urinary bladder cancer | Mutant | 2 |
| WHSC1 | urinary bladder cancer | Other | 19 |
| WHSC1 | uterine cancer | Mutant | 3 |
| WHSC1 | uterine cancer | Other | 15 |
| CYP19A1 | breast cancer | Mutant | 1 |
| CYP19A1 | breast cancer | Other | 25 |
| CYP19A1 | esophageal cancer | Mutant | 1 |
| CYP19A1 | esophageal cancer | Other | 13 |
| CYP19A1 | lymphoma | Mutant | 1 |
| CYP19A1 | lymphoma | Other | 10 |
| CYP19A1 | peripheral nervous system neoplasm | Mutant | 1 |
| CYP19A1 | peripheral nervous system neoplasm | Other | 12 |
| CYP19A1 | stomach cancer | Mutant | 1 |
| CYP19A1 | stomach cancer | Other | 14 |
| CYP19A1 | urinary bladder cancer | Mutant | 1 |
| CYP19A1 | urinary bladder cancer | Other | 20 |
| CYP19A1 | uterine cancer | Mutant | 2 |
| CYP19A1 | uterine cancer | Other | 16 |
| ATM | breast cancer | Mutant | 3 |
| ATM | breast cancer | Other | 23 |
| ATM | cancer | Mutant | 2 |
| ATM | cancer | Other | 15 |
| ATM | central nervous system cancer | Mutant | 3 |
| ATM | central nervous system cancer | Other | 43 |
| ATM | colorectal cancer | Mutant | 6 |
| ATM | colorectal cancer | Other | 21 |
| ATM | esophageal cancer | Mutant | 1 |
| ATM | esophageal cancer | Other | 13 |
| ATM | head and neck cancer | Mutant | 1 |
| ATM | head and neck cancer | Other | 14 |
| ATM | kidney cancer | Mutant | 4 |
| ATM | kidney cancer | Other | 18 |
| ATM | leukemia | Mutant | 3 |
| ATM | leukemia | Other | 19 |
| ATM | liver cancer | Mutant | 2 |
| ATM | liver cancer | Other | 14 |
| ATM | lung cancer | Mutant | 16 |
| ATM | lung cancer | Other | 54 |
| ATM | lymphoma | Mutant | 3 |
| ATM | lymphoma | Other | 8 |
| ATM | multiple myeloma | Mutant | 4 |
| ATM | multiple myeloma | Other | 12 |
| ATM | ovarian cancer | Mutant | 9 |
| ATM | ovarian cancer | Other | 27 |
| ATM | pancreatic cancer | Mutant | 1 |
| ATM | pancreatic cancer | Other | 22 |
| ATM | peripheral nervous system neoplasm | Mutant | 2 |
| ATM | peripheral nervous system neoplasm | Other | 12 |
| ATM | rhabdomyosarcoma | Mutant | 1 |
| ATM | rhabdomyosarcoma | Other | 6 |
| ATM | skin cancer | Mutant | 5 |
| ATM | skin cancer | Other | 23 |
| ATM | stomach cancer | Mutant | 2 |
| ATM | stomach cancer | Other | 13 |
| ATM | thyroid cancer | Mutant | 2 |
| ATM | thyroid cancer | Other | 1 |
| ATM | urinary bladder cancer | Mutant | 6 |
| ATM | urinary bladder cancer | Other | 16 |
| ATM | uterine cancer | Mutant | 12 |
| ATM | uterine cancer | Other | 9 |
| DPYD | bone cancer | Mutant | 1 |
| DPYD | bone cancer | Other | 15 |
| DPYD | breast cancer | Mutant | 2 |
| DPYD | breast cancer | Other | 24 |
| DPYD | central nervous system cancer | Mutant | 1 |
| DPYD | central nervous system cancer | Other | 44 |
| DPYD | colorectal cancer | Mutant | 4 |
| DPYD | colorectal cancer | Other | 24 |
| DPYD | head and neck cancer | Mutant | 1 |
| DPYD | head and neck cancer | Other | 14 |
| DPYD | kidney cancer | Mutant | 2 |
| DPYD | kidney cancer | Other | 20 |
| DPYD | leukemia | Mutant | 1 |
| DPYD | leukemia | Other | 21 |
| DPYD | liver cancer | Mutant | 1 |
| DPYD | liver cancer | Other | 15 |
| DPYD | lung cancer | Mutant | 4 |
| DPYD | lung cancer | Other | 65 |
| DPYD | lymphoma | Mutant | 1 |
| DPYD | lymphoma | Other | 10 |
| DPYD | multiple myeloma | Mutant | 1 |
| DPYD | multiple myeloma | Other | 15 |
| DPYD | ovarian cancer | Mutant | 2 |
| DPYD | ovarian cancer | Other | 33 |
| DPYD | rhabdomyosarcoma | Mutant | 1 |
| DPYD | rhabdomyosarcoma | Other | 6 |
| DPYD | skin cancer | Mutant | 4 |
| DPYD | skin cancer | Other | 25 |
| DPYD | urinary bladder cancer | Mutant | 1 |
| DPYD | urinary bladder cancer | Other | 20 |
| DPYD | uterine cancer | Mutant | 2 |
| DPYD | uterine cancer | Other | 16 |
| CREBBP | breast cancer | Mutant | 3 |
| CREBBP | breast cancer | Other | 23 |
| CREBBP | cancer | Mutant | 1 |
| CREBBP | cancer | Other | 16 |
| CREBBP | central nervous system cancer | Mutant | 5 |
| CREBBP | central nervous system cancer | Other | 40 |
| CREBBP | colorectal cancer | Mutant | 7 |
| CREBBP | colorectal cancer | Other | 22 |
| CREBBP | esophageal cancer | Mutant | 1 |
| CREBBP | esophageal cancer | Other | 12 |
| CREBBP | head and neck cancer | Mutant | 5 |
| CREBBP | head and neck cancer | Other | 10 |
| CREBBP | kidney cancer | Mutant | 1 |
| CREBBP | kidney cancer | Other | 21 |
| CREBBP | leukemia | Mutant | 6 |
| CREBBP | leukemia | Other | 14 |
| CREBBP | liver cancer | Mutant | 1 |
| CREBBP | liver cancer | Other | 15 |
| CREBBP | lung cancer | Mutant | 8 |
| CREBBP | lung cancer | Other | 61 |
| CREBBP | lymphoma | Mutant | 3 |
| CREBBP | lymphoma | Other | 8 |
| CREBBP | ovarian cancer | Mutant | 6 |
| CREBBP | ovarian cancer | Other | 30 |
| CREBBP | pancreatic cancer | Mutant | 1 |
| CREBBP | pancreatic cancer | Other | 22 |
| CREBBP | peripheral nervous system neoplasm | Mutant | 1 |
| CREBBP | peripheral nervous system neoplasm | Other | 12 |
| CREBBP | rhabdomyosarcoma | Mutant | 1 |
| CREBBP | rhabdomyosarcoma | Other | 6 |
| CREBBP | skin cancer | Mutant | 2 |
| CREBBP | skin cancer | Other | 28 |
| CREBBP | urinary bladder cancer | Mutant | 2 |
| CREBBP | urinary bladder cancer | Other | 20 |
| CREBBP | uterine cancer | Mutant | 9 |
| CREBBP | uterine cancer | Other | 10 |
ccle_data_ptmuts <- filter(ccle_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
ccle_data_ptmuts$Keep_PtMut_Tests <- ifelse(ccle_data_ptmuts$Reference_Allele_Length == 1 | is.na(ccle_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(ccle_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
ccle_data_ptmuts <- filter(ccle_data_ptmuts, Keep_PtMut_Tests == TRUE)
ccle_data_lvlA <- filter(ccle_data_ptmuts, Hugo_Symbol %in% genes_lvlA)
ccle_signif_lvlA_ByDrug <- lapply(unique(ccle_data_lvlA$Drug), WilcoxonByDrug, dataset = ccle_data_lvlA, data_name = "CCLE")
names(ccle_signif_lvlA_ByDrug) <- unique(ccle_data_lvlA$Drug)
saveRDS(ccle_signif_lvlA_ByDrug, "./data_munging/rds/ccle_signif_lvlA_ByDrug.rds")
ccle_signif_lvlA <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = c("Drug", "Hugo_Symbol"), data = ccle_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
ccle_signif_lvlA <- adj_signif(ccle_signif_lvlA)
ccle_signif_lvlA <- ccle_signif_lvlA[order(ccle_signif_lvlA$p),]
saveRDS(ccle_signif_lvlA, "./data_munging/rds/ccle_signif_lvlA_gene.rds")
ccle_signif_lvlA <- readRDS("./data_munging/rds/ccle_signif_lvlA_gene.rds")
knitr::kable(ccle_signif_lvlA[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| BRAF | selumetinib | 0.0000000 | 0.0000316 | 4.8e-08 | **** | **** |
| NRAS | selumetinib | 0.0000274 | 0.0089603 | 2.7e-05 | **** | ** |
| KRAS | selumetinib | 0.0004853 | 0.1058056 | 0.00049 | *** | NA |
| ETV6 | selumetinib | 0.0021320 | 0.3485845 | 0.00213 | ** | NA |
| CDKN2A | selumetinib | 0.0042499 | 0.5558840 | 0.00425 | ** | NA |
| JAK1 | irinotecan | 0.0074451 | 0.6534999 | 0.00745 | ** | NA |
| FBXW7 | irinotecan | 0.0090628 | 0.6534999 | 0.00906 | ** | NA |
| PRPF8 | selumetinib | 0.0099673 | 0.6534999 | 0.00997 | ** | NA |
| PAX8 | nilotinib | 0.0106011 | 0.6534999 | 0.01060 |
|
NA |
| KRAS | irinotecan | 0.0107870 | 0.6534999 | 0.01079 |
|
NA |
| ASXL1 | selumetinib | 0.0111516 | 0.6534999 | 0.01115 |
|
NA |
| ERBB3 | lapatinib | 0.0129696 | 0.6534999 | 0.01297 |
|
NA |
| FLT3 | irinotecan | 0.0133264 | 0.6534999 | 0.01333 |
|
NA |
| ASXL1 | lapatinib | 0.0139893 | 0.6534999 | 0.01399 |
|
NA |
| MPL | selumetinib | 0.0172826 | 0.7436311 | 0.01728 |
|
NA |
| SETD2 | irinotecan | 0.0181928 | 0.7436311 | 0.01819 |
|
NA |
| ERBB3 | nilotinib | 0.0219026 | 0.8139309 | 0.02190 |
|
NA |
| BRAF | erlotinib | 0.0224018 | 0.8139309 | 0.02240 |
|
NA |
| XPO1 | nilotinib | 0.0251623 | 0.8661135 | 0.02516 |
|
NA |
| CD274 | erlotinib | 0.0296833 | 0.8817295 | 0.02968 |
|
NA |
| KIT | lapatinib | 0.0299886 | 0.8817295 | 0.02999 |
|
NA |
| XPO1 | lapatinib | 0.0354732 | 0.8817295 | 0.03547 |
|
NA |
| ERBB2 | erlotinib | 0.0361008 | 0.8817295 | 0.03610 |
|
NA |
| ZRSR2 | irinotecan | 0.0372753 | 0.8817295 | 0.03728 |
|
NA |
| RUNX1 | selumetinib | 0.0372876 | 0.8817295 | 0.03729 |
|
NA |
| PDGFB | erlotinib | 0.0406263 | 0.8817295 | 0.04063 |
|
NA |
| TSC2 | irinotecan | 0.0425134 | 0.8817295 | 0.04251 |
|
NA |
| MAP2K2 | nilotinib | 0.0477901 | 0.8817295 | 0.04779 |
|
NA |
| WT1 | lapatinib | 0.0500201 | 0.8817295 | 0.05002 | NA | NA |
| ERBB2 | lapatinib | 0.0500292 | 0.8817295 | 0.05003 | NA | NA |
| NOTCH2 | erlotinib | 0.0501837 | 0.8817295 | 0.05018 | NA | NA |
| CD274 | lapatinib | 0.0504368 | 0.8817295 | 0.05044 | NA | NA |
| MYCN | erlotinib | 0.0511362 | 0.8817295 | 0.05114 | NA | NA |
| DDIT3 | irinotecan | 0.0544500 | 0.8817295 | 0.05445 | NA | NA |
| EED | irinotecan | 0.0574304 | 0.8817295 | 0.05743 | NA | NA |
| UGT1A1 | nilotinib | 0.0574932 | 0.8817295 | 0.05749 | NA | NA |
| CRLF2 | erlotinib | 0.0586240 | 0.8817295 | 0.05862 | NA | NA |
| WHSC1 | selumetinib | 0.0603852 | 0.8817295 | 0.06039 | NA | NA |
| NOTCH2 | irinotecan | 0.0615243 | 0.8817295 | 0.06152 | NA | NA |
| DNAJB1 | erlotinib | 0.0624342 | 0.8817295 | 0.06243 | NA | NA |
| IDH1 | erlotinib | 0.0637744 | 0.8817295 | 0.06377 | NA | NA |
| ROS1 | lapatinib | 0.0638294 | 0.8817295 | 0.06383 | NA | NA |
| PTEN | selumetinib | 0.0676687 | 0.8817295 | 0.06767 | NA | NA |
| CEBPA | lapatinib | 0.0701353 | 0.8817295 | 0.07014 | NA | NA |
| JAK2 | irinotecan | 0.0704563 | 0.8817295 | 0.07046 | NA | NA |
| PIGA | erlotinib | 0.0708932 | 0.8817295 | 0.07089 | NA | NA |
| CALR | erlotinib | 0.0711196 | 0.8817295 | 0.07112 | NA | NA |
| MGMT | lapatinib | 0.0716529 | 0.8817295 | 0.07165 | NA | NA |
| CXCR4 | erlotinib | 0.0741100 | 0.8817295 | 0.07411 | NA | NA |
| WHSC1 | nilotinib | 0.0752617 | 0.8817295 | 0.07526 | NA | NA |
| CRLF2 | lapatinib | 0.0760006 | 0.8817295 | 0.07600 | NA | NA |
| RAD21 | lapatinib | 0.0773127 | 0.8817295 | 0.07731 | NA | NA |
| SMO | selumetinib | 0.0780507 | 0.8817295 | 0.07805 | NA | NA |
| IDH1 | selumetinib | 0.0795440 | 0.8817295 | 0.07954 | NA | NA |
| BRCA2 | selumetinib | 0.0801455 | 0.8817295 | 0.08015 | NA | NA |
| BRAF | nilotinib | 0.0823341 | 0.8817295 | 0.08233 | NA | NA |
| ZRSR2 | nilotinib | 0.0823935 | 0.8817295 | 0.08239 | NA | NA |
| G6PD | selumetinib | 0.0848649 | 0.8817295 | 0.08486 | NA | NA |
| CDK4 | irinotecan | 0.0868856 | 0.8817295 | 0.08689 | NA | NA |
| MAP2K1 | nilotinib | 0.0869990 | 0.8817295 | 0.08700 | NA | NA |
| FGFR2 | irinotecan | 0.0873862 | 0.8817295 | 0.08739 | NA | NA |
| DNMT3A | lapatinib | 0.0910216 | 0.8817295 | 0.09102 | NA | NA |
| CBLB | nilotinib | 0.0920561 | 0.8817295 | 0.09206 | NA | NA |
| IDH2 | selumetinib | 0.0923191 | 0.8817295 | 0.09232 | NA | NA |
| ROS1 | erlotinib | 0.0964090 | 0.8817295 | 0.09641 | NA | NA |
| NCOA2 | nilotinib | 0.0971203 | 0.8817295 | 0.09712 | NA | NA |
| G6PD | nilotinib | 0.0978349 | 0.8817295 | 0.09783 | NA | NA |
| AKT1 | irinotecan | 0.0995560 | 0.8817295 | 0.09956 | NA | NA |
| PIGA | nilotinib | 0.1007178 | 0.8817295 | 0.10072 | NA | NA |
| STAG2 | erlotinib | 0.1047686 | 0.8817295 | 0.10477 | NA | NA |
| CBLB | lapatinib | 0.1059300 | 0.8817295 | 0.10593 | NA | NA |
| SRSF2 | lapatinib | 0.1089131 | 0.8817295 | 0.10891 | NA | NA |
| AKT3 | selumetinib | 0.1094130 | 0.8817295 | 0.10941 | NA | NA |
| EZH2 | selumetinib | 0.1105216 | 0.8817295 | 0.11052 | NA | NA |
| PTCH1 | selumetinib | 0.1105610 | 0.8817295 | 0.11056 | NA | NA |
| TET2 | lapatinib | 0.1133220 | 0.8817295 | 0.11332 | NA | NA |
| BCOR | selumetinib | 0.1155220 | 0.8817295 | 0.11552 | NA | NA |
| DNAJB1 | lapatinib | 0.1176422 | 0.8817295 | 0.11764 | NA | NA |
| GNAS | selumetinib | 0.1198231 | 0.8817295 | 0.11982 | NA | NA |
| U2AF1 | erlotinib | 0.1205628 | 0.8817295 | 0.12056 | NA | NA |
| CDC73 | irinotecan | 0.1207285 | 0.8817295 | 0.12073 | NA | NA |
| CTLA4 | erlotinib | 0.1220555 | 0.8817295 | 0.12206 | NA | NA |
| BRAF | irinotecan | 0.1223433 | 0.8817295 | 0.12234 | NA | NA |
| EML4 | irinotecan | 0.1225636 | 0.8817295 | 0.12256 | NA | NA |
| EML4 | erlotinib | 0.1250336 | 0.8817295 | 0.12503 | NA | NA |
| PDGFRA | selumetinib | 0.1271928 | 0.8817295 | 0.12719 | NA | NA |
| ZRSR2 | selumetinib | 0.1277334 | 0.8817295 | 0.12773 | NA | NA |
| NOTCH1 | lapatinib | 0.1297020 | 0.8817295 | 0.12970 | NA | NA |
| MAP2K2 | erlotinib | 0.1309379 | 0.8817295 | 0.13094 | NA | NA |
| AKT1 | nilotinib | 0.1319214 | 0.8817295 | 0.13192 | NA | NA |
| SMC1A | erlotinib | 0.1324733 | 0.8817295 | 0.13247 | NA | NA |
| ATM | irinotecan | 0.1329381 | 0.8817295 | 0.13294 | NA | NA |
| TSC2 | lapatinib | 0.1353477 | 0.8817295 | 0.13535 | NA | NA |
| KMT2A | selumetinib | 0.1379561 | 0.8817295 | 0.13796 | NA | NA |
| PHF6 | erlotinib | 0.1395872 | 0.8817295 | 0.13959 | NA | NA |
| GATA2 | erlotinib | 0.1428705 | 0.8817295 | 0.14287 | NA | NA |
| BRCA2 | lapatinib | 0.1454060 | 0.8817295 | 0.14541 | NA | NA |
| SMO | erlotinib | 0.1461317 | 0.8817295 | 0.14613 | NA | NA |
| AR | erlotinib | 0.1463011 | 0.8817295 | 0.14630 | NA | NA |
| DNMT3A | selumetinib | 0.1475871 | 0.8817295 | 0.14759 | NA | NA |
| PDGFRA | erlotinib | 0.1494369 | 0.8817295 | 0.14944 | NA | NA |
| CD274 | nilotinib | 0.1500406 | 0.8817295 | 0.15004 | NA | NA |
| CSF3R | selumetinib | 0.1508988 | 0.8817295 | 0.15090 | NA | NA |
| ERBB3 | erlotinib | 0.1517945 | 0.8817295 | 0.15179 | NA | NA |
| CALR | lapatinib | 0.1520641 | 0.8817295 | 0.15206 | NA | NA |
| PDGFRA | lapatinib | 0.1524894 | 0.8817295 | 0.15249 | NA | NA |
| BRAF | lapatinib | 0.1535431 | 0.8817295 | 0.15354 | NA | NA |
| WT1 | erlotinib | 0.1553226 | 0.8817295 | 0.15532 | NA | NA |
| MGMT | erlotinib | 0.1554862 | 0.8817295 | 0.15549 | NA | NA |
| EML4 | nilotinib | 0.1557059 | 0.8817295 | 0.15571 | NA | NA |
| FANCL | lapatinib | 0.1575032 | 0.8817295 | 0.15750 | NA | NA |
| GNB1 | irinotecan | 0.1580732 | 0.8817295 | 0.15807 | NA | NA |
| RET | lapatinib | 0.1587070 | 0.8817295 | 0.15871 | NA | NA |
| SF1 | lapatinib | 0.1589503 | 0.8817295 | 0.15895 | NA | NA |
| CBLB | erlotinib | 0.1604334 | 0.8817295 | 0.16043 | NA | NA |
| ERBB4 | irinotecan | 0.1615181 | 0.8817295 | 0.16152 | NA | NA |
| ESR1 | irinotecan | 0.1628356 | 0.8817295 | 0.16284 | NA | NA |
| STAG2 | selumetinib | 0.1648011 | 0.8817295 | 0.16480 | NA | NA |
| ERBB4 | nilotinib | 0.1674099 | 0.8817295 | 0.16741 | NA | NA |
| GNA11 | nilotinib | 0.1690832 | 0.8817295 | 0.16908 | NA | NA |
| CTLA4 | lapatinib | 0.1692151 | 0.8817295 | 0.16922 | NA | NA |
| CTLA4 | irinotecan | 0.1702373 | 0.8817295 | 0.17024 | NA | NA |
| DPYD | nilotinib | 0.1716871 | 0.8817295 | 0.17169 | NA | NA |
| MET | erlotinib | 0.1724618 | 0.8817295 | 0.17246 | NA | NA |
| JAK2 | selumetinib | 0.1725059 | 0.8817295 | 0.17251 | NA | NA |
| SF1 | erlotinib | 0.1731756 | 0.8817295 | 0.17318 | NA | NA |
| JAK1 | selumetinib | 0.1737020 | 0.8817295 | 0.17370 | NA | NA |
| CDC73 | nilotinib | 0.1737485 | 0.8817295 | 0.17375 | NA | NA |
| PIK3CA | selumetinib | 0.1739191 | 0.8817295 | 0.17392 | NA | NA |
| ASXL1 | erlotinib | 0.1754940 | 0.8828700 | 0.17549 | NA | NA |
| TPMT | irinotecan | 0.1771488 | 0.8843918 | 0.17715 | NA | NA |
| IDH2 | nilotinib | 0.1844993 | 0.8878919 | 0.18450 | NA | NA |
| XPO1 | erlotinib | 0.1879584 | 0.8878919 | 0.18796 | NA | NA |
| PDGFB | lapatinib | 0.1902003 | 0.8878919 | 0.19020 | NA | NA |
| PAX5 | irinotecan | 0.1910949 | 0.8878919 | 0.19109 | NA | NA |
| SRSF2 | selumetinib | 0.1939112 | 0.8878919 | 0.19391 | NA | NA |
| TP53 | lapatinib | 0.1940528 | 0.8878919 | 0.19405 | NA | NA |
| IKZF1 | irinotecan | 0.1945005 | 0.8878919 | 0.19450 | NA | NA |
| PHF6 | nilotinib | 0.1953337 | 0.8878919 | 0.19533 | NA | NA |
| CD79B | irinotecan | 0.1953386 | 0.8878919 | 0.19534 | NA | NA |
| FBXW7 | nilotinib | 0.1956027 | 0.8878919 | 0.19560 | NA | NA |
| EED | nilotinib | 0.1957988 | 0.8878919 | 0.19580 | NA | NA |
| ATM | nilotinib | 0.1967220 | 0.8878919 | 0.19672 | NA | NA |
| CEBPA | nilotinib | 0.1968300 | 0.8878919 | 0.19683 | NA | NA |
| DNAJB1 | nilotinib | 0.2009226 | 0.8878919 | 0.20092 | NA | NA |
| CSF3R | erlotinib | 0.2026368 | 0.8878919 | 0.20264 | NA | NA |
| IKZF1 | nilotinib | 0.2030879 | 0.8878919 | 0.20309 | NA | NA |
| FBXW7 | lapatinib | 0.2051047 | 0.8878919 | 0.20510 | NA | NA |
| JAK2 | erlotinib | 0.2076226 | 0.8878919 | 0.20762 | NA | NA |
| FGFR2 | selumetinib | 0.2084067 | 0.8878919 | 0.20841 | NA | NA |
| GNAQ | lapatinib | 0.2084358 | 0.8878919 | 0.20844 | NA | NA |
| IDH2 | erlotinib | 0.2087321 | 0.8878919 | 0.20873 | NA | NA |
| CTCF | erlotinib | 0.2093239 | 0.8878919 | 0.20932 | NA | NA |
| JAK3 | nilotinib | 0.2106747 | 0.8878919 | 0.21067 | NA | NA |
| MYCN | lapatinib | 0.2118132 | 0.8878919 | 0.21181 | NA | NA |
| CREBBP | lapatinib | 0.2121723 | 0.8878919 | 0.21217 | NA | NA |
| PDGFRB | irinotecan | 0.2131484 | 0.8878919 | 0.21315 | NA | NA |
| CDK6 | nilotinib | 0.2163351 | 0.8935947 | 0.21634 | NA | NA |
| ETV6 | lapatinib | 0.2197037 | 0.8935947 | 0.21970 | NA | NA |
| CALR | nilotinib | 0.2199033 | 0.8935947 | 0.21990 | NA | NA |
| PTEN | erlotinib | 0.2232818 | 0.8935947 | 0.22328 | NA | NA |
| PDCD1 | lapatinib | 0.2263464 | 0.8935947 | 0.22635 | NA | NA |
| PRPF8 | nilotinib | 0.2273928 | 0.8935947 | 0.22739 | NA | NA |
| MDM2 | lapatinib | 0.2279558 | 0.8935947 | 0.22796 | NA | NA |
| EGFR | irinotecan | 0.2306603 | 0.8935947 | 0.23066 | NA | NA |
| FANCL | selumetinib | 0.2375039 | 0.8935947 | 0.23750 | NA | NA |
| CREBBP | irinotecan | 0.2415640 | 0.8935947 | 0.24156 | NA | NA |
| U2AF1 | lapatinib | 0.2430493 | 0.8935947 | 0.24305 | NA | NA |
| MGMT | irinotecan | 0.2444998 | 0.8935947 | 0.24450 | NA | NA |
| ERBB2 | nilotinib | 0.2469369 | 0.8935947 | 0.24694 | NA | NA |
| JAK2 | lapatinib | 0.2481605 | 0.8935947 | 0.24816 | NA | NA |
| FGFR2 | erlotinib | 0.2494792 | 0.8935947 | 0.24948 | NA | NA |
| NOTCH1 | selumetinib | 0.2510449 | 0.8935947 | 0.25104 | NA | NA |
| NRAS | lapatinib | 0.2515364 | 0.8935947 | 0.25154 | NA | NA |
| BRCA2 | irinotecan | 0.2519045 | 0.8935947 | 0.25190 | NA | NA |
| SETBP1 | irinotecan | 0.2535542 | 0.8935947 | 0.25355 | NA | NA |
| FANCL | nilotinib | 0.2544008 | 0.8935947 | 0.25440 | NA | NA |
| PRPF40B | irinotecan | 0.2545052 | 0.8935947 | 0.25451 | NA | NA |
| VHL | selumetinib | 0.2554789 | 0.8935947 | 0.25548 | NA | NA |
| EED | lapatinib | 0.2560293 | 0.8935947 | 0.25603 | NA | NA |
| DPYD | irinotecan | 0.2565617 | 0.8935947 | 0.25656 | NA | NA |
| CREBBP | erlotinib | 0.2568307 | 0.8935947 | 0.25683 | NA | NA |
| PTEN | nilotinib | 0.2586912 | 0.8935947 | 0.25869 | NA | NA |
| ZRSR2 | erlotinib | 0.2598896 | 0.8935947 | 0.25989 | NA | NA |
| PDGFB | nilotinib | 0.2614178 | 0.8935947 | 0.26142 | NA | NA |
| NPM1 | lapatinib | 0.2652151 | 0.8935947 | 0.26522 | NA | NA |
| PML | lapatinib | 0.2673135 | 0.8935947 | 0.26731 | NA | NA |
| U2AF1 | irinotecan | 0.2686219 | 0.8935947 | 0.26862 | NA | NA |
| TP53 | irinotecan | 0.2699212 | 0.8935947 | 0.26992 | NA | NA |
| DNMT3A | irinotecan | 0.2699431 | 0.8935947 | 0.26994 | NA | NA |
| GNB1 | nilotinib | 0.2703894 | 0.8935947 | 0.27039 | NA | NA |
| VHL | lapatinib | 0.2715493 | 0.8935947 | 0.27155 | NA | NA |
| IL7R | irinotecan | 0.2748197 | 0.8935947 | 0.27482 | NA | NA |
| NOTCH2 | lapatinib | 0.2759280 | 0.8935947 | 0.27593 | NA | NA |
| ETV6 | irinotecan | 0.2759762 | 0.8935947 | 0.27598 | NA | NA |
| PAX8 | selumetinib | 0.2784348 | 0.8935947 | 0.27843 | NA | NA |
| GNAS | irinotecan | 0.2798045 | 0.8935947 | 0.27980 | NA | NA |
| SMC3 | selumetinib | 0.2800304 | 0.8935947 | 0.28003 | NA | NA |
| CEBPA | erlotinib | 0.2814510 | 0.8935947 | 0.28145 | NA | NA |
| CRLF2 | nilotinib | 0.2819017 | 0.8935947 | 0.28190 | NA | NA |
| GNA11 | irinotecan | 0.2837623 | 0.8935947 | 0.28376 | NA | NA |
| GNAQ | erlotinib | 0.2841793 | 0.8935947 | 0.28418 | NA | NA |
| RPL10 | nilotinib | 0.2850268 | 0.8935947 | 0.28503 | NA | NA |
| GATA1 | selumetinib | 0.2877975 | 0.8935947 | 0.28780 | NA | NA |
| EGF | erlotinib | 0.2884798 | 0.8935947 | 0.28848 | NA | NA |
| RIT1 | selumetinib | 0.2890366 | 0.8935947 | 0.28904 | NA | NA |
| RAD21 | erlotinib | 0.2894193 | 0.8935947 | 0.28942 | NA | NA |
| STAG2 | irinotecan | 0.2896816 | 0.8935947 | 0.28968 | NA | NA |
| BRCA2 | erlotinib | 0.2904280 | 0.8935947 | 0.29043 | NA | NA |
| KRAS | nilotinib | 0.2905710 | 0.8935947 | 0.29057 | NA | NA |
| IDH1 | nilotinib | 0.2908172 | 0.8935947 | 0.29082 | NA | NA |
| RIT1 | irinotecan | 0.2916381 | 0.8935947 | 0.29164 | NA | NA |
| GATA3 | irinotecan | 0.2950313 | 0.8935947 | 0.29503 | NA | NA |
| SETBP1 | nilotinib | 0.2960817 | 0.8935947 | 0.29608 | NA | NA |
| PIK3CA | nilotinib | 0.2965860 | 0.8935947 | 0.29659 | NA | NA |
| FLCN | lapatinib | 0.2981455 | 0.8935947 | 0.29815 | NA | NA |
| NT5C2 | selumetinib | 0.2993317 | 0.8935947 | 0.29933 | NA | NA |
| CDK4 | erlotinib | 0.3023854 | 0.8935947 | 0.30239 | NA | NA |
| DDIT3 | nilotinib | 0.3025069 | 0.8935947 | 0.30251 | NA | NA |
| TSC1 | selumetinib | 0.3026265 | 0.8935947 | 0.30263 | NA | NA |
| CBL | selumetinib | 0.3063751 | 0.8935947 | 0.30638 | NA | NA |
| PML | erlotinib | 0.3071538 | 0.8935947 | 0.30715 | NA | NA |
| CDK4 | nilotinib | 0.3095790 | 0.8935947 | 0.30958 | NA | NA |
| SH2B3 | nilotinib | 0.3095790 | 0.8935947 | 0.30958 | NA | NA |
| SMC3 | nilotinib | 0.3146584 | 0.8935947 | 0.31466 | NA | NA |
| RET | selumetinib | 0.3162948 | 0.8935947 | 0.31629 | NA | NA |
| GATA1 | nilotinib | 0.3176333 | 0.8935947 | 0.31763 | NA | NA |
| CALR | irinotecan | 0.3188346 | 0.8935947 | 0.31883 | NA | NA |
| PIK3CA | irinotecan | 0.3207286 | 0.8935947 | 0.32073 | NA | NA |
| MAP2K2 | selumetinib | 0.3219772 | 0.8935947 | 0.32198 | NA | NA |
| JAK2 | nilotinib | 0.3242397 | 0.8935947 | 0.32424 | NA | NA |
| STAT3 | nilotinib | 0.3252695 | 0.8935947 | 0.32527 | NA | NA |
| GATA1 | lapatinib | 0.3258106 | 0.8935947 | 0.32581 | NA | NA |
| NCOA2 | lapatinib | 0.3280718 | 0.8935947 | 0.32807 | NA | NA |
| CYP19A1 | irinotecan | 0.3281397 | 0.8935947 | 0.32814 | NA | NA |
| PDCD1 | erlotinib | 0.3307646 | 0.8935947 | 0.33076 | NA | NA |
| RAD21 | irinotecan | 0.3328997 | 0.8935947 | 0.33290 | NA | NA |
| CDC73 | erlotinib | 0.3331184 | 0.8935947 | 0.33312 | NA | NA |
| GNA11 | erlotinib | 0.3332076 | 0.8935947 | 0.33321 | NA | NA |
| STAT3 | lapatinib | 0.3335387 | 0.8935947 | 0.33354 | NA | NA |
| EED | erlotinib | 0.3343486 | 0.8935947 | 0.33435 | NA | NA |
| EZH2 | lapatinib | 0.3363420 | 0.8935947 | 0.33634 | NA | NA |
| STAT3 | irinotecan | 0.3391154 | 0.8935947 | 0.33912 | NA | NA |
| GATA2 | selumetinib | 0.3395397 | 0.8935947 | 0.33954 | NA | NA |
| PAX8 | irinotecan | 0.3425029 | 0.8935947 | 0.34250 | NA | NA |
| KRAS | erlotinib | 0.3430622 | 0.8935947 | 0.34306 | NA | NA |
| CD79B | nilotinib | 0.3432244 | 0.8935947 | 0.34322 | NA | NA |
| ASXL1 | nilotinib | 0.3452112 | 0.8935947 | 0.34521 | NA | NA |
| GATA3 | selumetinib | 0.3459306 | 0.8935947 | 0.34593 | NA | NA |
| PIK3CA | erlotinib | 0.3473764 | 0.8935947 | 0.34738 | NA | NA |
| GATA2 | irinotecan | 0.3492471 | 0.8935947 | 0.34925 | NA | NA |
| BTK | selumetinib | 0.3507388 | 0.8935947 | 0.35074 | NA | NA |
| IDH1 | lapatinib | 0.3512958 | 0.8935947 | 0.35130 | NA | NA |
| EGF | nilotinib | 0.3535275 | 0.8935947 | 0.35353 | NA | NA |
| FGFR1 | lapatinib | 0.3538617 | 0.8935947 | 0.35386 | NA | NA |
| SF1 | irinotecan | 0.3571830 | 0.8935947 | 0.35718 | NA | NA |
| EML4 | lapatinib | 0.3576785 | 0.8935947 | 0.35768 | NA | NA |
| MET | irinotecan | 0.3595819 | 0.8935947 | 0.35958 | NA | NA |
| SMO | lapatinib | 0.3610953 | 0.8935947 | 0.36110 | NA | NA |
| CYP19A1 | nilotinib | 0.3614358 | 0.8935947 | 0.36144 | NA | NA |
| BRCA1 | erlotinib | 0.3656704 | 0.8935947 | 0.36567 | NA | NA |
| CYP19A1 | selumetinib | 0.3657355 | 0.8935947 | 0.36574 | NA | NA |
| MYD88 | irinotecan | 0.3660517 | 0.8935947 | 0.36605 | NA | NA |
| AR | irinotecan | 0.3668667 | 0.8935947 | 0.36687 | NA | NA |
| ETV6 | erlotinib | 0.3694510 | 0.8935947 | 0.36945 | NA | NA |
| RPL10 | lapatinib | 0.3697756 | 0.8935947 | 0.36978 | NA | NA |
| CEBPA | selumetinib | 0.3714072 | 0.8935947 | 0.37141 | NA | NA |
| KRAS | lapatinib | 0.3717079 | 0.8935947 | 0.37171 | NA | NA |
| TP53 | selumetinib | 0.3730400 | 0.8935947 | 0.37304 | NA | NA |
| CDK4 | selumetinib | 0.3739875 | 0.8935947 | 0.37399 | NA | NA |
| MET | nilotinib | 0.3749787 | 0.8935947 | 0.37498 | NA | NA |
| RET | erlotinib | 0.3769409 | 0.8935947 | 0.37694 | NA | NA |
| EGFR | erlotinib | 0.3780620 | 0.8935947 | 0.37806 | NA | NA |
| BTK | lapatinib | 0.3783216 | 0.8935947 | 0.37832 | NA | NA |
| CD79B | selumetinib | 0.3789936 | 0.8935947 | 0.37899 | NA | NA |
| SF3B1 | selumetinib | 0.3794567 | 0.8935947 | 0.37946 | NA | NA |
| SRSF2 | nilotinib | 0.3795016 | 0.8935947 | 0.37950 | NA | NA |
| MAP2K1 | lapatinib | 0.3798461 | 0.8935947 | 0.37985 | NA | NA |
| AKT3 | erlotinib | 0.3831353 | 0.8981021 | 0.38314 | NA | NA |
| CTNNB1 | erlotinib | 0.3868718 | 0.9016265 | 0.38687 | NA | NA |
| SMC1A | selumetinib | 0.3873961 | 0.9016265 | 0.38740 | NA | NA |
| AKT3 | lapatinib | 0.3897579 | 0.9017376 | 0.38976 | NA | NA |
| NRAS | irinotecan | 0.3909888 | 0.9017376 | 0.39099 | NA | NA |
| KIT | erlotinib | 0.3945572 | 0.9017376 | 0.39456 | NA | NA |
| PAX5 | nilotinib | 0.3950175 | 0.9017376 | 0.39502 | NA | NA |
| NCOA2 | erlotinib | 0.3950763 | 0.9017376 | 0.39508 | NA | NA |
| CBLB | selumetinib | 0.3957166 | 0.9017376 | 0.39572 | NA | NA |
| NOTCH1 | erlotinib | 0.4015628 | 0.9118822 | 0.40156 | NA | NA |
| NPM1 | erlotinib | 0.4081068 | 0.9202658 | 0.40811 | NA | NA |
| AKT1 | erlotinib | 0.4089836 | 0.9202658 | 0.40898 | NA | NA |
| GNAQ | nilotinib | 0.4094761 | 0.9202658 | 0.40948 | NA | NA |
| TSC2 | erlotinib | 0.4143017 | 0.9253688 | 0.41430 | NA | NA |
| ALK | irinotecan | 0.4159284 | 0.9253688 | 0.41593 | NA | NA |
| MAP2K1 | irinotecan | 0.4180667 | 0.9253688 | 0.41807 | NA | NA |
| HRAS | erlotinib | 0.4181676 | 0.9253688 | 0.41817 | NA | NA |
| CDK6 | selumetinib | 0.4197911 | 0.9253688 | 0.41979 | NA | NA |
| RAD21 | selumetinib | 0.4202363 | 0.9253688 | 0.42024 | NA | NA |
| HRAS | lapatinib | 0.4223510 | 0.9269045 | 0.42235 | NA | NA |
| VHL | irinotecan | 0.4240695 | 0.9275634 | 0.42407 | NA | NA |
| MPL | lapatinib | 0.4272603 | 0.9283631 | 0.42726 | NA | NA |
| WHSC1 | lapatinib | 0.4278387 | 0.9283631 | 0.42784 | NA | NA |
| KIT | selumetinib | 0.4291048 | 0.9283631 | 0.42910 | NA | NA |
| SETBP1 | erlotinib | 0.4301182 | 0.9283631 | 0.43012 | NA | NA |
| PIK3CA | lapatinib | 0.4324195 | 0.9283631 | 0.43242 | NA | NA |
| BRCA2 | nilotinib | 0.4329522 | 0.9283631 | 0.43295 | NA | NA |
| SETBP1 | selumetinib | 0.4352803 | 0.9303049 | 0.43528 | NA | NA |
| GNB1 | selumetinib | 0.4390316 | 0.9320078 | 0.43903 | NA | NA |
| DNMT3A | nilotinib | 0.4393202 | 0.9320078 | 0.43932 | NA | NA |
| FBXW7 | selumetinib | 0.4403523 | 0.9320078 | 0.44035 | NA | NA |
| ABL1 | lapatinib | 0.4453225 | 0.9370319 | 0.44532 | NA | NA |
| RAD21 | nilotinib | 0.4455916 | 0.9370319 | 0.44559 | NA | NA |
| BTK | irinotecan | 0.4499106 | 0.9419721 | 0.44991 | NA | NA |
| SMC3 | erlotinib | 0.4530753 | 0.9419721 | 0.45308 | NA | NA |
| FLT3 | erlotinib | 0.4536996 | 0.9419721 | 0.45370 | NA | NA |
| MPL | nilotinib | 0.4540395 | 0.9419721 | 0.45404 | NA | NA |
| ESR1 | selumetinib | 0.4556101 | 0.9419721 | 0.45561 | NA | NA |
| GNB1 | lapatinib | 0.4579231 | 0.9419721 | 0.45792 | NA | NA |
| MYD88 | lapatinib | 0.4587151 | 0.9419721 | 0.45872 | NA | NA |
| CD274 | irinotecan | 0.4598390 | 0.9419721 | 0.45984 | NA | NA |
| ALK | lapatinib | 0.4609038 | 0.9419721 | 0.46090 | NA | NA |
| SRSF2 | erlotinib | 0.4661229 | 0.9424744 | 0.46612 | NA | NA |
| CD274 | selumetinib | 0.4672104 | 0.9424744 | 0.46721 | NA | NA |
| MDM2 | erlotinib | 0.4709707 | 0.9424744 | 0.47097 | NA | NA |
| CTLA4 | selumetinib | 0.4717193 | 0.9424744 | 0.47172 | NA | NA |
| DNAJB1 | irinotecan | 0.4725298 | 0.9424744 | 0.47253 | NA | NA |
| STAT3 | selumetinib | 0.4741982 | 0.9424744 | 0.47420 | NA | NA |
| CRLF2 | selumetinib | 0.4762722 | 0.9424744 | 0.47627 | NA | NA |
| PAX8 | lapatinib | 0.4777998 | 0.9424744 | 0.47780 | NA | NA |
| SMC3 | irinotecan | 0.4778543 | 0.9424744 | 0.47785 | NA | NA |
| FBXW7 | erlotinib | 0.4790992 | 0.9424744 | 0.47910 | NA | NA |
| DDIT3 | erlotinib | 0.4794295 | 0.9424744 | 0.47943 | NA | NA |
| PDGFRB | nilotinib | 0.4795241 | 0.9424744 | 0.47952 | NA | NA |
| PHF6 | irinotecan | 0.4809070 | 0.9424744 | 0.48091 | NA | NA |
| BCORL1 | erlotinib | 0.4833897 | 0.9424744 | 0.48339 | NA | NA |
| ROS1 | irinotecan | 0.4834670 | 0.9424744 | 0.48347 | NA | NA |
| TPMT | erlotinib | 0.4842070 | 0.9424744 | 0.48421 | NA | NA |
| GNA11 | lapatinib | 0.4911808 | 0.9517886 | 0.49118 | NA | NA |
| HRAS | selumetinib | 0.4931995 | 0.9517886 | 0.49320 | NA | NA |
| CD79B | erlotinib | 0.4933583 | 0.9517886 | 0.49336 | NA | NA |
| DPYD | lapatinib | 0.4951753 | 0.9524843 | 0.49518 | NA | NA |
| NT5C2 | nilotinib | 0.4985874 | 0.9562351 | 0.49859 | NA | NA |
| FGFR3 | erlotinib | 0.5057821 | 0.9671974 | 0.50578 | NA | NA |
| NOTCH1 | irinotecan | 0.5083990 | 0.9693671 | 0.50840 | NA | NA |
| PDGFB | irinotecan | 0.5117862 | 0.9696657 | 0.51179 | NA | NA |
| TET2 | irinotecan | 0.5145990 | 0.9696657 | 0.51460 | NA | NA |
| PTPN11 | irinotecan | 0.5165017 | 0.9696657 | 0.51650 | NA | NA |
| CTCF | lapatinib | 0.5174017 | 0.9696657 | 0.51740 | NA | NA |
| IDH1 | irinotecan | 0.5177897 | 0.9696657 | 0.51779 | NA | NA |
| ESR1 | nilotinib | 0.5209092 | 0.9696657 | 0.52091 | NA | NA |
| NPM1 | nilotinib | 0.5225901 | 0.9696657 | 0.52259 | NA | NA |
| ETV6 | nilotinib | 0.5231112 | 0.9696657 | 0.52311 | NA | NA |
| VHL | nilotinib | 0.5249231 | 0.9696657 | 0.52492 | NA | NA |
| EML4 | selumetinib | 0.5261206 | 0.9696657 | 0.52612 | NA | NA |
| MAP2K1 | erlotinib | 0.5270899 | 0.9696657 | 0.52709 | NA | NA |
| TP53 | nilotinib | 0.5288472 | 0.9696657 | 0.52885 | NA | NA |
| CDKN2A | nilotinib | 0.5300461 | 0.9696657 | 0.53005 | NA | NA |
| PRPF40B | nilotinib | 0.5310239 | 0.9696657 | 0.53102 | NA | NA |
| AKT2 | selumetinib | 0.5332426 | 0.9696657 | 0.53324 | NA | NA |
| BRCA1 | lapatinib | 0.5346294 | 0.9696657 | 0.53463 | NA | NA |
| IDH2 | irinotecan | 0.5383687 | 0.9696657 | 0.53837 | NA | NA |
| GATA3 | lapatinib | 0.5384377 | 0.9696657 | 0.53844 | NA | NA |
| NOTCH2 | nilotinib | 0.5393383 | 0.9696657 | 0.53934 | NA | NA |
| IL7R | lapatinib | 0.5439112 | 0.9696657 | 0.54391 | NA | NA |
| ESR1 | erlotinib | 0.5463206 | 0.9696657 | 0.54632 | NA | NA |
| SRSF2 | irinotecan | 0.5486376 | 0.9696657 | 0.54864 | NA | NA |
| VHL | erlotinib | 0.5488405 | 0.9696657 | 0.54884 | NA | NA |
| IKZF1 | lapatinib | 0.5493652 | 0.9696657 | 0.54937 | NA | NA |
| FGFR3 | selumetinib | 0.5504813 | 0.9696657 | 0.55048 | NA | NA |
| FLCN | erlotinib | 0.5527653 | 0.9696657 | 0.55277 | NA | NA |
| ATM | lapatinib | 0.5550964 | 0.9696657 | 0.55510 | NA | NA |
| CREBBP | selumetinib | 0.5551165 | 0.9696657 | 0.55512 | NA | NA |
| PDCD1 | nilotinib | 0.5606283 | 0.9696657 | 0.56063 | NA | NA |
| KMT2A | irinotecan | 0.5662482 | 0.9696657 | 0.56625 | NA | NA |
| MET | lapatinib | 0.5678884 | 0.9696657 | 0.56789 | NA | NA |
| CEBPA | irinotecan | 0.5694611 | 0.9696657 | 0.56946 | NA | NA |
| SMO | nilotinib | 0.5711686 | 0.9696657 | 0.57117 | NA | NA |
| PTPN11 | selumetinib | 0.5722801 | 0.9696657 | 0.57228 | NA | NA |
| CYP19A1 | erlotinib | 0.5725012 | 0.9696657 | 0.57250 | NA | NA |
| EGF | lapatinib | 0.5756426 | 0.9696657 | 0.57564 | NA | NA |
| EGFR | selumetinib | 0.5763443 | 0.9696657 | 0.57634 | NA | NA |
| GATA2 | lapatinib | 0.5776923 | 0.9696657 | 0.57769 | NA | NA |
| JAK3 | selumetinib | 0.5791652 | 0.9696657 | 0.57917 | NA | NA |
| CALR | selumetinib | 0.5793494 | 0.9696657 | 0.57935 | NA | NA |
| CTNNB1 | nilotinib | 0.5810417 | 0.9696657 | 0.58104 | NA | NA |
| PIGA | irinotecan | 0.5810477 | 0.9696657 | 0.58105 | NA | NA |
| PDGFRB | lapatinib | 0.5810825 | 0.9696657 | 0.58108 | NA | NA |
| CTNNB1 | lapatinib | 0.5823848 | 0.9696657 | 0.58238 | NA | NA |
| CSF3R | nilotinib | 0.5848095 | 0.9696657 | 0.58481 | NA | NA |
| JAK1 | lapatinib | 0.5848719 | 0.9696657 | 0.58487 | NA | NA |
| MAP2K1 | selumetinib | 0.5850648 | 0.9696657 | 0.58506 | NA | NA |
| SSX1 | nilotinib | 0.5863196 | 0.9696657 | 0.58632 | NA | NA |
| PRPF40B | erlotinib | 0.5871846 | 0.9696657 | 0.58718 | NA | NA |
| IL7R | erlotinib | 0.5879645 | 0.9696657 | 0.58796 | NA | NA |
| UGT1A1 | lapatinib | 0.5880643 | 0.9696657 | 0.58806 | NA | NA |
| RIT1 | lapatinib | 0.5908467 | 0.9696657 | 0.59085 | NA | NA |
| FLT3 | nilotinib | 0.5913464 | 0.9696657 | 0.59135 | NA | NA |
| PDGFRA | irinotecan | 0.5925752 | 0.9696657 | 0.59258 | NA | NA |
| GNAS | lapatinib | 0.5958805 | 0.9696657 | 0.59588 | NA | NA |
| NT5C2 | irinotecan | 0.5962588 | 0.9696657 | 0.59626 | NA | NA |
| RET | nilotinib | 0.5975829 | 0.9696657 | 0.59758 | NA | NA |
| CDK4 | lapatinib | 0.5976694 | 0.9696657 | 0.59767 | NA | NA |
| NRAS | nilotinib | 0.5977193 | 0.9696657 | 0.59772 | NA | NA |
| JAK3 | irinotecan | 0.5999452 | 0.9696657 | 0.59995 | NA | NA |
| TSC1 | irinotecan | 0.6014923 | 0.9696657 | 0.60149 | NA | NA |
| SETD2 | lapatinib | 0.6015271 | 0.9696657 | 0.60153 | NA | NA |
| AKT1 | lapatinib | 0.6019637 | 0.9696657 | 0.60196 | NA | NA |
| CBL | nilotinib | 0.6047466 | 0.9699710 | 0.60475 | NA | NA |
| PTPN11 | nilotinib | 0.6063462 | 0.9699710 | 0.60635 | NA | NA |
| CBL | erlotinib | 0.6066026 | 0.9699710 | 0.60660 | NA | NA |
| SF1 | nilotinib | 0.6086888 | 0.9709328 | 0.60869 | NA | NA |
| TSC2 | selumetinib | 0.6111574 | 0.9724987 | 0.61116 | NA | NA |
| CDKN2A | lapatinib | 0.6158264 | 0.9765194 | 0.61583 | NA | NA |
| RUNX1 | lapatinib | 0.6166705 | 0.9765194 | 0.61667 | NA | NA |
| JAK3 | lapatinib | 0.6237232 | 0.9842813 | 0.62372 | NA | NA |
| ERBB2 | irinotecan | 0.6286426 | 0.9842813 | 0.62864 | NA | NA |
| PML | irinotecan | 0.6294330 | 0.9842813 | 0.62943 | NA | NA |
| FANCL | irinotecan | 0.6327514 | 0.9842813 | 0.63275 | NA | NA |
| G6PD | lapatinib | 0.6332410 | 0.9842813 | 0.63324 | NA | NA |
| CXCR4 | irinotecan | 0.6348669 | 0.9842813 | 0.63487 | NA | NA |
| ATM | selumetinib | 0.6349288 | 0.9842813 | 0.63493 | NA | NA |
| SETBP1 | lapatinib | 0.6353669 | 0.9842813 | 0.63537 | NA | NA |
| RET | irinotecan | 0.6389716 | 0.9842813 | 0.63897 | NA | NA |
| CTCF | nilotinib | 0.6405142 | 0.9842813 | 0.64051 | NA | NA |
| TSC1 | erlotinib | 0.6505989 | 0.9842813 | 0.65060 | NA | NA |
| AKT3 | irinotecan | 0.6506008 | 0.9842813 | 0.65060 | NA | NA |
| CDC73 | selumetinib | 0.6511899 | 0.9842813 | 0.65119 | NA | NA |
| SMC1A | lapatinib | 0.6516111 | 0.9842813 | 0.65161 | NA | NA |
| CBL | lapatinib | 0.6524341 | 0.9842813 | 0.65243 | NA | NA |
| MET | selumetinib | 0.6524774 | 0.9842813 | 0.65248 | NA | NA |
| WHSC1 | irinotecan | 0.6542440 | 0.9842813 | 0.65424 | NA | NA |
| PDCD1 | irinotecan | 0.6545590 | 0.9842813 | 0.65456 | NA | NA |
| U2AF1 | selumetinib | 0.6577081 | 0.9842813 | 0.65771 | NA | NA |
| GATA1 | erlotinib | 0.6580401 | 0.9842813 | 0.65804 | NA | NA |
| KIT | nilotinib | 0.6606331 | 0.9842813 | 0.66063 | NA | NA |
| IKZF1 | selumetinib | 0.6611150 | 0.9842813 | 0.66111 | NA | NA |
| ABL1 | selumetinib | 0.6628862 | 0.9842813 | 0.66289 | NA | NA |
| PDGFRB | selumetinib | 0.6645199 | 0.9842813 | 0.66452 | NA | NA |
| ABL1 | irinotecan | 0.6660281 | 0.9842813 | 0.66603 | NA | NA |
| TPMT | nilotinib | 0.6679929 | 0.9842813 | 0.66799 | NA | NA |
| JAK1 | nilotinib | 0.6683405 | 0.9842813 | 0.66834 | NA | NA |
| GNB1 | erlotinib | 0.6685175 | 0.9842813 | 0.66852 | NA | NA |
| PRPF40B | selumetinib | 0.6689523 | 0.9842813 | 0.66895 | NA | NA |
| CTNNB1 | irinotecan | 0.6690072 | 0.9842813 | 0.66901 | NA | NA |
| AR | lapatinib | 0.6705630 | 0.9842813 | 0.67056 | NA | NA |
| MDM2 | selumetinib | 0.6727814 | 0.9842813 | 0.67278 | NA | NA |
| EZH2 | irinotecan | 0.6733468 | 0.9842813 | 0.67335 | NA | NA |
| CTNNB1 | selumetinib | 0.6746071 | 0.9842813 | 0.67461 | NA | NA |
| AKT3 | nilotinib | 0.6789529 | 0.9842813 | 0.67895 | NA | NA |
| FGFR1 | nilotinib | 0.6796758 | 0.9842813 | 0.67968 | NA | NA |
| EED | selumetinib | 0.6798049 | 0.9842813 | 0.67980 | NA | NA |
| FLCN | selumetinib | 0.6802253 | 0.9842813 | 0.68023 | NA | NA |
| EGF | selumetinib | 0.6802678 | 0.9842813 | 0.68027 | NA | NA |
| ROS1 | nilotinib | 0.6819122 | 0.9844825 | 0.68191 | NA | NA |
| DPYD | erlotinib | 0.6840148 | 0.9853430 | 0.68401 | NA | NA |
| DPYD | selumetinib | 0.6868738 | 0.9857566 | 0.68687 | NA | NA |
| BTK | erlotinib | 0.6873166 | 0.9857566 | 0.68732 | NA | NA |
| PIGA | lapatinib | 0.6899301 | 0.9861415 | 0.68993 | NA | NA |
| MYD88 | nilotinib | 0.6912056 | 0.9861415 | 0.69121 | NA | NA |
| TSC2 | nilotinib | 0.6921085 | 0.9861415 | 0.69211 | NA | NA |
| CYP19A1 | lapatinib | 0.6950890 | 0.9882352 | 0.69509 | NA | NA |
| IKZF1 | erlotinib | 0.7003041 | 0.9917784 | 0.70030 | NA | NA |
| PRPF8 | irinotecan | 0.7015023 | 0.9917784 | 0.70150 | NA | NA |
| NRAS | erlotinib | 0.7042626 | 0.9917784 | 0.70426 | NA | NA |
| RIT1 | erlotinib | 0.7055740 | 0.9917784 | 0.70557 | NA | NA |
| WHSC1 | erlotinib | 0.7063712 | 0.9917784 | 0.70637 | NA | NA |
| PTPN11 | erlotinib | 0.7104107 | 0.9917784 | 0.71041 | NA | NA |
| ZRSR2 | lapatinib | 0.7127565 | 0.9917784 | 0.71276 | NA | NA |
| PTCH1 | irinotecan | 0.7162618 | 0.9917784 | 0.71626 | NA | NA |
| SF3B1 | irinotecan | 0.7173061 | 0.9917784 | 0.71731 | NA | NA |
| PDCD1 | selumetinib | 0.7186602 | 0.9917784 | 0.71866 | NA | NA |
| NOTCH2 | selumetinib | 0.7202092 | 0.9917784 | 0.72021 | NA | NA |
| SSX1 | erlotinib | 0.7213924 | 0.9917784 | 0.72139 | NA | NA |
| SH2B3 | lapatinib | 0.7233868 | 0.9917784 | 0.72339 | NA | NA |
| DDIT3 | selumetinib | 0.7243926 | 0.9917784 | 0.72439 | NA | NA |
| MYD88 | selumetinib | 0.7246756 | 0.9917784 | 0.72468 | NA | NA |
| ATM | erlotinib | 0.7248163 | 0.9917784 | 0.72482 | NA | NA |
| JAK3 | erlotinib | 0.7290446 | 0.9917784 | 0.72904 | NA | NA |
| PTCH1 | erlotinib | 0.7302464 | 0.9917784 | 0.73025 | NA | NA |
| BTK | nilotinib | 0.7312736 | 0.9917784 | 0.73127 | NA | NA |
| BCORL1 | selumetinib | 0.7333376 | 0.9917784 | 0.73334 | NA | NA |
| CBLB | irinotecan | 0.7342163 | 0.9917784 | 0.73422 | NA | NA |
| EZH2 | erlotinib | 0.7344706 | 0.9917784 | 0.73447 | NA | NA |
| TSC1 | lapatinib | 0.7401698 | 0.9917784 | 0.74017 | NA | NA |
| RUNX1 | erlotinib | 0.7408697 | 0.9917784 | 0.74087 | NA | NA |
| PIGA | selumetinib | 0.7421261 | 0.9917784 | 0.74213 | NA | NA |
| JAK1 | erlotinib | 0.7446534 | 0.9917784 | 0.74465 | NA | NA |
| TET2 | nilotinib | 0.7479864 | 0.9917784 | 0.74799 | NA | NA |
| FGFR3 | nilotinib | 0.7486898 | 0.9917784 | 0.74869 | NA | NA |
| GATA1 | irinotecan | 0.7510689 | 0.9917784 | 0.75107 | NA | NA |
| PRPF40B | lapatinib | 0.7523713 | 0.9917784 | 0.75237 | NA | NA |
| FLCN | nilotinib | 0.7541296 | 0.9917784 | 0.75413 | NA | NA |
| RPL10 | irinotecan | 0.7548056 | 0.9917784 | 0.75481 | NA | NA |
| SETD2 | nilotinib | 0.7552064 | 0.9917784 | 0.75521 | NA | NA |
| GNA11 | selumetinib | 0.7569104 | 0.9917784 | 0.75691 | NA | NA |
| CDC73 | lapatinib | 0.7574639 | 0.9917784 | 0.75746 | NA | NA |
| SMC1A | irinotecan | 0.7580493 | 0.9917784 | 0.75805 | NA | NA |
| NCOA2 | selumetinib | 0.7585886 | 0.9917784 | 0.75859 | NA | NA |
| FGFR3 | irinotecan | 0.7590167 | 0.9917784 | 0.75902 | NA | NA |
| CREBBP | nilotinib | 0.7621143 | 0.9917784 | 0.76211 | NA | NA |
| PDGFB | selumetinib | 0.7634636 | 0.9917784 | 0.76346 | NA | NA |
| CRLF2 | irinotecan | 0.7651322 | 0.9917784 | 0.76513 | NA | NA |
| FGFR3 | lapatinib | 0.7703491 | 0.9917784 | 0.77035 | NA | NA |
| MAP2K2 | lapatinib | 0.7714479 | 0.9917784 | 0.77145 | NA | NA |
| SSX1 | irinotecan | 0.7716424 | 0.9917784 | 0.77164 | NA | NA |
| ERBB4 | erlotinib | 0.7781237 | 0.9917784 | 0.77812 | NA | NA |
| G6PD | erlotinib | 0.7787902 | 0.9917784 | 0.77879 | NA | NA |
| CTLA4 | nilotinib | 0.7791419 | 0.9917784 | 0.77914 | NA | NA |
| FGFR1 | erlotinib | 0.7800078 | 0.9917784 | 0.78001 | NA | NA |
| HRAS | irinotecan | 0.7830688 | 0.9917784 | 0.78307 | NA | NA |
| AR | selumetinib | 0.7836835 | 0.9917784 | 0.78368 | NA | NA |
| SMC3 | lapatinib | 0.7862153 | 0.9917784 | 0.78622 | NA | NA |
| PTCH1 | lapatinib | 0.7871784 | 0.9917784 | 0.78718 | NA | NA |
| KMT2A | erlotinib | 0.7907716 | 0.9917784 | 0.79077 | NA | NA |
| PHF6 | selumetinib | 0.7908963 | 0.9917784 | 0.79090 | NA | NA |
| EGFR | lapatinib | 0.7947247 | 0.9917784 | 0.79472 | NA | NA |
| BCOR | nilotinib | 0.7961781 | 0.9917784 | 0.79618 | NA | NA |
| GNAS | erlotinib | 0.7962137 | 0.9917784 | 0.79621 | NA | NA |
| PAX8 | erlotinib | 0.7962376 | 0.9917784 | 0.79624 | NA | NA |
| RUNX1 | irinotecan | 0.7975944 | 0.9917784 | 0.79759 | NA | NA |
| GATA3 | nilotinib | 0.7977219 | 0.9917784 | 0.79772 | NA | NA |
| SMC1A | nilotinib | 0.7980647 | 0.9917784 | 0.79806 | NA | NA |
| ALK | nilotinib | 0.7983903 | 0.9917784 | 0.79839 | NA | NA |
| SSX1 | selumetinib | 0.7987359 | 0.9917784 | 0.79874 | NA | NA |
| SMO | irinotecan | 0.7988480 | 0.9917784 | 0.79885 | NA | NA |
| TSC1 | nilotinib | 0.7988924 | 0.9917784 | 0.79889 | NA | NA |
| ERBB4 | lapatinib | 0.8042029 | 0.9917784 | 0.80420 | NA | NA |
| GATA2 | nilotinib | 0.8059928 | 0.9917784 | 0.80599 | NA | NA |
| AKT2 | irinotecan | 0.8069935 | 0.9917784 | 0.80699 | NA | NA |
| RUNX1 | nilotinib | 0.8073074 | 0.9917784 | 0.80731 | NA | NA |
| WT1 | selumetinib | 0.8117996 | 0.9917784 | 0.81180 | NA | NA |
| AR | nilotinib | 0.8128485 | 0.9917784 | 0.81285 | NA | NA |
| MPL | erlotinib | 0.8134653 | 0.9917784 | 0.81347 | NA | NA |
| IDH2 | lapatinib | 0.8145125 | 0.9917784 | 0.81451 | NA | NA |
| SSX1 | lapatinib | 0.8176005 | 0.9917784 | 0.81760 | NA | NA |
| DNAJB1 | selumetinib | 0.8178008 | 0.9917784 | 0.81780 | NA | NA |
| CSF3R | irinotecan | 0.8191014 | 0.9917784 | 0.81910 | NA | NA |
| XPO1 | irinotecan | 0.8196641 | 0.9917784 | 0.81966 | NA | NA |
| BRCA1 | irinotecan | 0.8210965 | 0.9917784 | 0.82110 | NA | NA |
| CD79B | lapatinib | 0.8217468 | 0.9917784 | 0.82175 | NA | NA |
| ERBB2 | selumetinib | 0.8218228 | 0.9917784 | 0.82182 | NA | NA |
| UGT1A1 | erlotinib | 0.8238031 | 0.9917784 | 0.82380 | NA | NA |
| G6PD | irinotecan | 0.8254252 | 0.9917784 | 0.82543 | NA | NA |
| ROS1 | selumetinib | 0.8271911 | 0.9917784 | 0.82719 | NA | NA |
| ALK | selumetinib | 0.8278795 | 0.9917784 | 0.82788 | NA | NA |
| PDGFRB | erlotinib | 0.8279937 | 0.9917784 | 0.82799 | NA | NA |
| MGMT | nilotinib | 0.8301945 | 0.9917784 | 0.83019 | NA | NA |
| UGT1A1 | irinotecan | 0.8309879 | 0.9917784 | 0.83099 | NA | NA |
| FANCL | erlotinib | 0.8310314 | 0.9917784 | 0.83103 | NA | NA |
| DDIT3 | lapatinib | 0.8377397 | 0.9959455 | 0.83774 | NA | NA |
| FGFR1 | selumetinib | 0.8422202 | 0.9959455 | 0.84222 | NA | NA |
| NT5C2 | erlotinib | 0.8425719 | 0.9959455 | 0.84257 | NA | NA |
| ERBB4 | selumetinib | 0.8446106 | 0.9959455 | 0.84461 | NA | NA |
| MYCN | nilotinib | 0.8448350 | 0.9959455 | 0.84483 | NA | NA |
| KMT2A | lapatinib | 0.8454470 | 0.9959455 | 0.84545 | NA | NA |
| NCOA2 | irinotecan | 0.8517003 | 0.9959455 | 0.85170 | NA | NA |
| ABL1 | erlotinib | 0.8522490 | 0.9959455 | 0.85225 | NA | NA |
| IL7R | nilotinib | 0.8524502 | 0.9959455 | 0.85245 | NA | NA |
| FLT3 | selumetinib | 0.8527746 | 0.9959455 | 0.85277 | NA | NA |
| TET2 | erlotinib | 0.8613977 | 0.9959455 | 0.86140 | NA | NA |
| FLT3 | lapatinib | 0.8614733 | 0.9959455 | 0.86147 | NA | NA |
| PDGFRA | nilotinib | 0.8621321 | 0.9959455 | 0.86213 | NA | NA |
| SETD2 | selumetinib | 0.8627670 | 0.9959455 | 0.86277 | NA | NA |
| BCOR | lapatinib | 0.8638970 | 0.9959455 | 0.86390 | NA | NA |
| RPL10 | selumetinib | 0.8658058 | 0.9959455 | 0.86581 | NA | NA |
| ERBB3 | selumetinib | 0.8669447 | 0.9959455 | 0.86694 | NA | NA |
| CTCF | selumetinib | 0.8706349 | 0.9959455 | 0.87063 | NA | NA |
| CXCR4 | nilotinib | 0.8733725 | 0.9959455 | 0.87337 | NA | NA |
| CDKN2A | erlotinib | 0.8747139 | 0.9959455 | 0.87471 | NA | NA |
| EZH2 | nilotinib | 0.8752021 | 0.9959455 | 0.87520 | NA | NA |
| NT5C2 | lapatinib | 0.8753678 | 0.9959455 | 0.87537 | NA | NA |
| STAG2 | nilotinib | 0.8759840 | 0.9959455 | 0.87598 | NA | NA |
| BCORL1 | lapatinib | 0.8806185 | 0.9959455 | 0.88062 | NA | NA |
| NPM1 | selumetinib | 0.8832243 | 0.9959455 | 0.88322 | NA | NA |
| STAG2 | lapatinib | 0.8834116 | 0.9959455 | 0.88341 | NA | NA |
| STAT3 | erlotinib | 0.8844399 | 0.9959455 | 0.88444 | NA | NA |
| KIT | irinotecan | 0.8862231 | 0.9959455 | 0.88622 | NA | NA |
| FGFR1 | irinotecan | 0.8871126 | 0.9959455 | 0.88711 | NA | NA |
| MYD88 | erlotinib | 0.8885739 | 0.9959455 | 0.88857 | NA | NA |
| MDM2 | nilotinib | 0.8889052 | 0.9959455 | 0.88891 | NA | NA |
| PRPF8 | lapatinib | 0.8893234 | 0.9959455 | 0.88932 | NA | NA |
| RIT1 | nilotinib | 0.8908541 | 0.9959455 | 0.89085 | NA | NA |
| UGT1A1 | selumetinib | 0.8917738 | 0.9959455 | 0.89177 | NA | NA |
| NPM1 | irinotecan | 0.8930026 | 0.9959455 | 0.89300 | NA | NA |
| NOTCH1 | nilotinib | 0.8983617 | 0.9959455 | 0.89836 | NA | NA |
| DNMT3A | erlotinib | 0.9005581 | 0.9959455 | 0.90056 | NA | NA |
| CBL | irinotecan | 0.9079854 | 0.9959455 | 0.90799 | NA | NA |
| KMT2A | nilotinib | 0.9084944 | 0.9959455 | 0.90849 | NA | NA |
| ASXL1 | irinotecan | 0.9089550 | 0.9959455 | 0.90895 | NA | NA |
| TPMT | lapatinib | 0.9089736 | 0.9959455 | 0.90897 | NA | NA |
| CDK6 | lapatinib | 0.9113470 | 0.9959455 | 0.91135 | NA | NA |
| GATA3 | erlotinib | 0.9119616 | 0.9959455 | 0.91196 | NA | NA |
| PML | nilotinib | 0.9170484 | 0.9959455 | 0.91705 | NA | NA |
| PAX5 | lapatinib | 0.9176528 | 0.9959455 | 0.91765 | NA | NA |
| AKT2 | lapatinib | 0.9180125 | 0.9959455 | 0.91801 | NA | NA |
| AKT1 | selumetinib | 0.9187209 | 0.9959455 | 0.91872 | NA | NA |
| PAX5 | selumetinib | 0.9213643 | 0.9959455 | 0.92136 | NA | NA |
| U2AF1 | nilotinib | 0.9215704 | 0.9959455 | 0.92157 | NA | NA |
| FLCN | irinotecan | 0.9219343 | 0.9959455 | 0.92193 | NA | NA |
| HRAS | nilotinib | 0.9225162 | 0.9959455 | 0.92252 | NA | NA |
| MGMT | selumetinib | 0.9254057 | 0.9959455 | 0.92541 | NA | NA |
| CTCF | irinotecan | 0.9262120 | 0.9959455 | 0.92621 | NA | NA |
| IL7R | selumetinib | 0.9287200 | 0.9959455 | 0.92872 | NA | NA |
| EGF | irinotecan | 0.9294390 | 0.9959455 | 0.92944 | NA | NA |
| AKT2 | nilotinib | 0.9311619 | 0.9959455 | 0.93116 | NA | NA |
| CXCR4 | selumetinib | 0.9335671 | 0.9959455 | 0.93357 | NA | NA |
| CDK6 | irinotecan | 0.9369407 | 0.9959455 | 0.93694 | NA | NA |
| BCOR | irinotecan | 0.9384232 | 0.9959455 | 0.93842 | NA | NA |
| SF1 | selumetinib | 0.9388121 | 0.9959455 | 0.93881 | NA | NA |
| TET2 | selumetinib | 0.9390759 | 0.9959455 | 0.93908 | NA | NA |
| PTEN | irinotecan | 0.9404034 | 0.9959455 | 0.94040 | NA | NA |
| SH2B3 | irinotecan | 0.9413890 | 0.9959455 | 0.94139 | NA | NA |
| MPL | irinotecan | 0.9419762 | 0.9959455 | 0.94198 | NA | NA |
| MDM2 | irinotecan | 0.9444299 | 0.9959455 | 0.94443 | NA | NA |
| SH2B3 | selumetinib | 0.9448071 | 0.9959455 | 0.94481 | NA | NA |
| PHF6 | lapatinib | 0.9451994 | 0.9959455 | 0.94520 | NA | NA |
| WT1 | irinotecan | 0.9470140 | 0.9959455 | 0.94701 | NA | NA |
| FGFR2 | nilotinib | 0.9470949 | 0.9959455 | 0.94709 | NA | NA |
| MAP2K2 | irinotecan | 0.9474730 | 0.9959455 | 0.94747 | NA | NA |
| ALK | erlotinib | 0.9492432 | 0.9959455 | 0.94924 | NA | NA |
| PML | selumetinib | 0.9504098 | 0.9959455 | 0.95041 | NA | NA |
| BRCA1 | nilotinib | 0.9506540 | 0.9959455 | 0.95065 | NA | NA |
| PTEN | lapatinib | 0.9516739 | 0.9959455 | 0.95167 | NA | NA |
| PTCH1 | nilotinib | 0.9525059 | 0.9959455 | 0.95251 | NA | NA |
| EGFR | nilotinib | 0.9540597 | 0.9959455 | 0.95406 | NA | NA |
| BRCA1 | selumetinib | 0.9592240 | 0.9959455 | 0.95922 | NA | NA |
| AKT2 | erlotinib | 0.9628110 | 0.9959455 | 0.96281 | NA | NA |
| ESR1 | lapatinib | 0.9641363 | 0.9959455 | 0.96414 | NA | NA |
| XPO1 | selumetinib | 0.9668163 | 0.9959455 | 0.96682 | NA | NA |
| CXCR4 | lapatinib | 0.9673812 | 0.9959455 | 0.96738 | NA | NA |
| BCORL1 | irinotecan | 0.9680876 | 0.9959455 | 0.96809 | NA | NA |
| ERBB3 | irinotecan | 0.9705439 | 0.9959455 | 0.97054 | NA | NA |
| PTPN11 | lapatinib | 0.9711271 | 0.9959455 | 0.97113 | NA | NA |
| CDKN2A | irinotecan | 0.9752204 | 0.9959455 | 0.97522 | NA | NA |
| GNAQ | selumetinib | 0.9752766 | 0.9959455 | 0.97528 | NA | NA |
| CDK6 | erlotinib | 0.9761607 | 0.9959455 | 0.97616 | NA | NA |
| PAX5 | erlotinib | 0.9776368 | 0.9959455 | 0.97764 | NA | NA |
| SETD2 | erlotinib | 0.9776368 | 0.9959455 | 0.97764 | NA | NA |
| SF3B1 | erlotinib | 0.9789551 | 0.9959455 | 0.97896 | NA | NA |
| TP53 | erlotinib | 0.9801201 | 0.9959455 | 0.98012 | NA | NA |
| GNAS | nilotinib | 0.9824645 | 0.9959455 | 0.98246 | NA | NA |
| RPL10 | erlotinib | 0.9825514 | 0.9959455 | 0.98255 | NA | NA |
| SF3B1 | nilotinib | 0.9834968 | 0.9959455 | 0.98350 | NA | NA |
| FGFR2 | lapatinib | 0.9842030 | 0.9959455 | 0.98420 | NA | NA |
| BCOR | erlotinib | 0.9848467 | 0.9959455 | 0.98485 | NA | NA |
| TPMT | selumetinib | 0.9863877 | 0.9959455 | 0.98639 | NA | NA |
| SF3B1 | lapatinib | 0.9865575 | 0.9959455 | 0.98656 | NA | NA |
| MYCN | selumetinib | 0.9888743 | 0.9959455 | 0.98887 | NA | NA |
| CSF3R | lapatinib | 0.9895734 | 0.9959455 | 0.98957 | NA | NA |
| PRPF8 | erlotinib | 0.9895951 | 0.9959455 | 0.98960 | NA | NA |
| SH2B3 | erlotinib | 0.9898541 | 0.9959455 | 0.98985 | NA | NA |
| MYCN | irinotecan | 0.9924251 | 0.9969985 | 0.99243 | NA | NA |
| WT1 | nilotinib | 0.9955641 | 0.9972248 | 0.99556 | NA | NA |
| BCORL1 | nilotinib | 0.9957000 | 0.9972248 | 0.99570 | NA | NA |
| ABL1 | nilotinib | 0.9989982 | 0.9989982 | 0.99900 | NA | NA |
ccle_signif_lvlA_ByDrug <- readRDS("./data_munging/rds/ccle_signif_lvlA_ByDrug.rds")
ccle_signif_lvlA_ByDrug_all <- rbindlist(ccle_signif_lvlA_ByDrug, use.names = TRUE)
ccle_signif_lvlA_ByDrug_all <- ccle_signif_lvlA_ByDrug_all[order(ccle_signif_lvlA_ByDrug_all$p.adj),]
knitr::kable(ccle_signif_lvlA_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: by-drug Wilcoxon test results for Level A point mutations, (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| BRAF | selumetinib | 0.0000000 | 0.0000063 | 4.8e-08 | **** | **** |
| NRAS | selumetinib | 0.0000274 | 0.0017948 | 2.7e-05 | **** | ** |
| KRAS | selumetinib | 0.0004853 | 0.0211935 | 0.00049 | *** |
|
| ETV6 | selumetinib | 0.0021320 | 0.0698235 | 0.00213 | ** | NA |
| CDKN2A | selumetinib | 0.0042499 | 0.1113468 | 0.00425 | ** | NA |
| PRPF8 | selumetinib | 0.0099673 | 0.2086951 | 0.00997 | ** | NA |
| ASXL1 | selumetinib | 0.0111516 | 0.2086951 | 0.01115 |
|
NA |
| MPL | selumetinib | 0.0172826 | 0.2830021 | 0.01728 |
|
NA |
| JAK1 | irinotecan | 0.0074451 | 0.4331076 | 0.0074 | ** | NA |
| FBXW7 | irinotecan | 0.0090628 | 0.4331076 | 0.0091 | ** | NA |
| KRAS | irinotecan | 0.0107870 | 0.4331076 | 0.0108 |
|
NA |
| FLT3 | irinotecan | 0.0133264 | 0.4331076 | 0.0133 |
|
NA |
| SETD2 | irinotecan | 0.0181928 | 0.4730131 | 0.0182 |
|
NA |
| RUNX1 | selumetinib | 0.0372876 | 0.5427417 | 0.03729 |
|
NA |
| WHSC1 | selumetinib | 0.0603852 | 0.7275248 | 0.06039 | NA | NA |
| PTEN | selumetinib | 0.0676687 | 0.7275248 | 0.06767 | NA | NA |
| SMO | selumetinib | 0.0780507 | 0.7275248 | 0.07805 | NA | NA |
| IDH1 | selumetinib | 0.0795440 | 0.7275248 | 0.07954 | NA | NA |
| BRCA2 | selumetinib | 0.0801455 | 0.7275248 | 0.08015 | NA | NA |
| G6PD | selumetinib | 0.0848649 | 0.7275248 | 0.08486 | NA | NA |
| IDH2 | selumetinib | 0.0923191 | 0.7275248 | 0.09232 | NA | NA |
| AKT3 | selumetinib | 0.1094130 | 0.7275248 | 0.10941 | NA | NA |
| EZH2 | selumetinib | 0.1105216 | 0.7275248 | 0.11052 | NA | NA |
| PTCH1 | selumetinib | 0.1105610 | 0.7275248 | 0.11056 | NA | NA |
| BCOR | selumetinib | 0.1155220 | 0.7275248 | 0.11552 | NA | NA |
| GNAS | selumetinib | 0.1198231 | 0.7275248 | 0.11982 | NA | NA |
| PDGFRA | selumetinib | 0.1271928 | 0.7275248 | 0.12719 | NA | NA |
| ZRSR2 | selumetinib | 0.1277334 | 0.7275248 | 0.12773 | NA | NA |
| BRAF | erlotinib | 0.0224018 | 0.7416038 | 0.022 |
|
NA |
| CD274 | erlotinib | 0.0296833 | 0.7416038 | 0.030 |
|
NA |
| ERBB2 | erlotinib | 0.0361008 | 0.7416038 | 0.036 |
|
NA |
| PDGFB | erlotinib | 0.0406263 | 0.7416038 | 0.041 |
|
NA |
| NOTCH2 | erlotinib | 0.0501837 | 0.7416038 | 0.050 | NA | NA |
| MYCN | erlotinib | 0.0511362 | 0.7416038 | 0.051 | NA | NA |
| CRLF2 | erlotinib | 0.0586240 | 0.7416038 | 0.059 | NA | NA |
| DNAJB1 | erlotinib | 0.0624342 | 0.7416038 | 0.062 | NA | NA |
| IDH1 | erlotinib | 0.0637744 | 0.7416038 | 0.064 | NA | NA |
| PIGA | erlotinib | 0.0708932 | 0.7416038 | 0.071 | NA | NA |
| CALR | erlotinib | 0.0711196 | 0.7416038 | 0.071 | NA | NA |
| CXCR4 | erlotinib | 0.0741100 | 0.7416038 | 0.074 | NA | NA |
| ROS1 | erlotinib | 0.0964090 | 0.7416038 | 0.096 | NA | NA |
| STAG2 | erlotinib | 0.1047686 | 0.7416038 | 0.105 | NA | NA |
| U2AF1 | erlotinib | 0.1205628 | 0.7416038 | 0.121 | NA | NA |
| CTLA4 | erlotinib | 0.1220555 | 0.7416038 | 0.122 | NA | NA |
| EML4 | erlotinib | 0.1250336 | 0.7416038 | 0.125 | NA | NA |
| MAP2K2 | erlotinib | 0.1309379 | 0.7416038 | 0.131 | NA | NA |
| SMC1A | erlotinib | 0.1324733 | 0.7416038 | 0.132 | NA | NA |
| PHF6 | erlotinib | 0.1395872 | 0.7416038 | 0.140 | NA | NA |
| GATA2 | erlotinib | 0.1428705 | 0.7416038 | 0.143 | NA | NA |
| SMO | erlotinib | 0.1461317 | 0.7416038 | 0.146 | NA | NA |
| AR | erlotinib | 0.1463011 | 0.7416038 | 0.146 | NA | NA |
| PDGFRA | erlotinib | 0.1494369 | 0.7416038 | 0.149 | NA | NA |
| ERBB3 | erlotinib | 0.1517945 | 0.7416038 | 0.152 | NA | NA |
| WT1 | erlotinib | 0.1553226 | 0.7416038 | 0.155 | NA | NA |
| MGMT | erlotinib | 0.1554862 | 0.7416038 | 0.155 | NA | NA |
| CBLB | erlotinib | 0.1604334 | 0.7416038 | 0.160 | NA | NA |
| MET | erlotinib | 0.1724618 | 0.7416038 | 0.172 | NA | NA |
| SF1 | erlotinib | 0.1731756 | 0.7416038 | 0.173 | NA | NA |
| ASXL1 | erlotinib | 0.1754940 | 0.7416038 | 0.175 | NA | NA |
| KMT2A | selumetinib | 0.1379561 | 0.7530106 | 0.13796 | NA | NA |
| DNMT3A | selumetinib | 0.1475871 | 0.7594468 | 0.14759 | NA | NA |
| CSF3R | selumetinib | 0.1508988 | 0.7594468 | 0.15090 | NA | NA |
| STAG2 | selumetinib | 0.1648011 | 0.7594468 | 0.16480 | NA | NA |
| JAK2 | selumetinib | 0.1725059 | 0.7594468 | 0.17251 | NA | NA |
| JAK1 | selumetinib | 0.1737020 | 0.7594468 | 0.17370 | NA | NA |
| PIK3CA | selumetinib | 0.1739191 | 0.7594468 | 0.17392 | NA | NA |
| XPO1 | erlotinib | 0.1879584 | 0.7617063 | 0.188 | NA | NA |
| CSF3R | erlotinib | 0.2026368 | 0.7617063 | 0.203 | NA | NA |
| JAK2 | erlotinib | 0.2076226 | 0.7617063 | 0.208 | NA | NA |
| IDH2 | erlotinib | 0.2087321 | 0.7617063 | 0.209 | NA | NA |
| CTCF | erlotinib | 0.2093239 | 0.7617063 | 0.209 | NA | NA |
| ZRSR2 | irinotecan | 0.0372753 | 0.7895340 | 0.0373 |
|
NA |
| TSC2 | irinotecan | 0.0425134 | 0.7895340 | 0.0425 |
|
NA |
| PTEN | erlotinib | 0.2232818 | 0.7905384 | 0.223 | NA | NA |
| DDIT3 | irinotecan | 0.0544500 | 0.7998163 | 0.0545 | NA | NA |
| EED | irinotecan | 0.0574304 | 0.7998163 | 0.0574 | NA | NA |
| NOTCH2 | irinotecan | 0.0615243 | 0.7998163 | 0.0615 | NA | NA |
| ERBB3 | lapatinib | 0.0129696 | 0.8008651 | 0.013 |
|
NA |
| ASXL1 | lapatinib | 0.0139893 | 0.8008651 | 0.014 |
|
NA |
| KIT | lapatinib | 0.0299886 | 0.8008651 | 0.030 |
|
NA |
| XPO1 | lapatinib | 0.0354732 | 0.8008651 | 0.035 |
|
NA |
| WT1 | lapatinib | 0.0500201 | 0.8008651 | 0.050 | NA | NA |
| ERBB2 | lapatinib | 0.0500292 | 0.8008651 | 0.050 | NA | NA |
| CD274 | lapatinib | 0.0504368 | 0.8008651 | 0.050 | NA | NA |
| ROS1 | lapatinib | 0.0638294 | 0.8008651 | 0.064 | NA | NA |
| CEBPA | lapatinib | 0.0701353 | 0.8008651 | 0.070 | NA | NA |
| MGMT | lapatinib | 0.0716529 | 0.8008651 | 0.072 | NA | NA |
| CRLF2 | lapatinib | 0.0760006 | 0.8008651 | 0.076 | NA | NA |
| RAD21 | lapatinib | 0.0773127 | 0.8008651 | 0.077 | NA | NA |
| DNMT3A | lapatinib | 0.0910216 | 0.8008651 | 0.091 | NA | NA |
| CBLB | lapatinib | 0.1059300 | 0.8008651 | 0.106 | NA | NA |
| SRSF2 | lapatinib | 0.1089131 | 0.8008651 | 0.109 | NA | NA |
| TET2 | lapatinib | 0.1133220 | 0.8008651 | 0.113 | NA | NA |
| DNAJB1 | lapatinib | 0.1176422 | 0.8008651 | 0.118 | NA | NA |
| NOTCH1 | lapatinib | 0.1297020 | 0.8008651 | 0.130 | NA | NA |
| TSC2 | lapatinib | 0.1353477 | 0.8008651 | 0.135 | NA | NA |
| BRCA2 | lapatinib | 0.1454060 | 0.8008651 | 0.145 | NA | NA |
| CALR | lapatinib | 0.1520641 | 0.8008651 | 0.152 | NA | NA |
| PDGFRA | lapatinib | 0.1524894 | 0.8008651 | 0.152 | NA | NA |
| BRAF | lapatinib | 0.1535431 | 0.8008651 | 0.154 | NA | NA |
| FANCL | lapatinib | 0.1575032 | 0.8008651 | 0.158 | NA | NA |
| RET | lapatinib | 0.1587070 | 0.8008651 | 0.159 | NA | NA |
| SF1 | lapatinib | 0.1589503 | 0.8008651 | 0.159 | NA | NA |
| SRSF2 | selumetinib | 0.1939112 | 0.8194311 | 0.19391 | NA | NA |
| CTLA4 | lapatinib | 0.1692151 | 0.8210066 | 0.169 | NA | NA |
| PDGFB | lapatinib | 0.1902003 | 0.8215129 | 0.190 | NA | NA |
| TP53 | lapatinib | 0.1940528 | 0.8215129 | 0.194 | NA | NA |
| FBXW7 | lapatinib | 0.2051047 | 0.8215129 | 0.205 | NA | NA |
| GNAQ | lapatinib | 0.2084358 | 0.8215129 | 0.208 | NA | NA |
| MYCN | lapatinib | 0.2118132 | 0.8215129 | 0.212 | NA | NA |
| CREBBP | lapatinib | 0.2121723 | 0.8215129 | 0.212 | NA | NA |
| ETV6 | lapatinib | 0.2197037 | 0.8215129 | 0.220 | NA | NA |
| PDCD1 | lapatinib | 0.2263464 | 0.8215129 | 0.226 | NA | NA |
| MDM2 | lapatinib | 0.2279558 | 0.8215129 | 0.228 | NA | NA |
| U2AF1 | lapatinib | 0.2430493 | 0.8215129 | 0.243 | NA | NA |
| JAK2 | lapatinib | 0.2481605 | 0.8215129 | 0.248 | NA | NA |
| NRAS | lapatinib | 0.2515364 | 0.8215129 | 0.252 | NA | NA |
| EED | lapatinib | 0.2560293 | 0.8215129 | 0.256 | NA | NA |
| NPM1 | lapatinib | 0.2652151 | 0.8215129 | 0.265 | NA | NA |
| PML | lapatinib | 0.2673135 | 0.8215129 | 0.267 | NA | NA |
| VHL | lapatinib | 0.2715493 | 0.8215129 | 0.272 | NA | NA |
| NOTCH2 | lapatinib | 0.2759280 | 0.8215129 | 0.276 | NA | NA |
| FGFR2 | erlotinib | 0.2494792 | 0.8299993 | 0.249 | NA | NA |
| CREBBP | erlotinib | 0.2568307 | 0.8299993 | 0.257 | NA | NA |
| ZRSR2 | erlotinib | 0.2598896 | 0.8299993 | 0.260 | NA | NA |
| CEBPA | erlotinib | 0.2814510 | 0.8299993 | 0.281 | NA | NA |
| GNAQ | erlotinib | 0.2841793 | 0.8299993 | 0.284 | NA | NA |
| EGF | erlotinib | 0.2884798 | 0.8299993 | 0.288 | NA | NA |
| RAD21 | erlotinib | 0.2894193 | 0.8299993 | 0.289 | NA | NA |
| BRCA2 | erlotinib | 0.2904280 | 0.8299993 | 0.290 | NA | NA |
| CDK4 | erlotinib | 0.3023854 | 0.8299993 | 0.302 | NA | NA |
| PML | erlotinib | 0.3071538 | 0.8299993 | 0.307 | NA | NA |
| PDCD1 | erlotinib | 0.3307646 | 0.8299993 | 0.331 | NA | NA |
| CDC73 | erlotinib | 0.3331184 | 0.8299993 | 0.333 | NA | NA |
| GNA11 | erlotinib | 0.3332076 | 0.8299993 | 0.333 | NA | NA |
| EED | erlotinib | 0.3343486 | 0.8299993 | 0.334 | NA | NA |
| KRAS | erlotinib | 0.3430622 | 0.8299993 | 0.343 | NA | NA |
| PIK3CA | erlotinib | 0.3473764 | 0.8299993 | 0.347 | NA | NA |
| BRCA1 | erlotinib | 0.3656704 | 0.8299993 | 0.366 | NA | NA |
| ETV6 | erlotinib | 0.3694510 | 0.8299993 | 0.369 | NA | NA |
| RET | erlotinib | 0.3769409 | 0.8299993 | 0.377 | NA | NA |
| EGFR | erlotinib | 0.3780620 | 0.8299993 | 0.378 | NA | NA |
| AKT3 | erlotinib | 0.3831353 | 0.8299993 | 0.383 | NA | NA |
| CTNNB1 | erlotinib | 0.3868718 | 0.8299993 | 0.387 | NA | NA |
| KIT | erlotinib | 0.3945572 | 0.8299993 | 0.395 | NA | NA |
| NCOA2 | erlotinib | 0.3950763 | 0.8299993 | 0.395 | NA | NA |
| NOTCH1 | erlotinib | 0.4015628 | 0.8299993 | 0.402 | NA | NA |
| NPM1 | erlotinib | 0.4081068 | 0.8299993 | 0.408 | NA | NA |
| AKT1 | erlotinib | 0.4089836 | 0.8299993 | 0.409 | NA | NA |
| TSC2 | erlotinib | 0.4143017 | 0.8299993 | 0.414 | NA | NA |
| HRAS | erlotinib | 0.4181676 | 0.8299993 | 0.418 | NA | NA |
| JAK2 | irinotecan | 0.0704563 | 0.8326652 | 0.0705 | NA | NA |
| SETBP1 | erlotinib | 0.4301182 | 0.8409775 | 0.430 | NA | NA |
| SMC3 | erlotinib | 0.4530753 | 0.8457483 | 0.453 | NA | NA |
| FLT3 | erlotinib | 0.4536996 | 0.8457483 | 0.454 | NA | NA |
| SRSF2 | erlotinib | 0.4661229 | 0.8457483 | 0.466 | NA | NA |
| MDM2 | erlotinib | 0.4709707 | 0.8457483 | 0.471 | NA | NA |
| FBXW7 | erlotinib | 0.4790992 | 0.8457483 | 0.479 | NA | NA |
| DDIT3 | erlotinib | 0.4794295 | 0.8457483 | 0.479 | NA | NA |
| BCORL1 | erlotinib | 0.4833897 | 0.8457483 | 0.483 | NA | NA |
| TPMT | erlotinib | 0.4842070 | 0.8457483 | 0.484 | NA | NA |
| CD79B | erlotinib | 0.4933583 | 0.8503939 | 0.493 | NA | NA |
| PAX8 | nilotinib | 0.0106011 | 0.8522061 | 0.011 |
|
NA |
| ERBB3 | nilotinib | 0.0219026 | 0.8522061 | 0.022 |
|
NA |
| XPO1 | nilotinib | 0.0251623 | 0.8522061 | 0.025 |
|
NA |
| MAP2K2 | nilotinib | 0.0477901 | 0.8522061 | 0.048 |
|
NA |
| UGT1A1 | nilotinib | 0.0574932 | 0.8522061 | 0.057 | NA | NA |
| WHSC1 | nilotinib | 0.0752617 | 0.8522061 | 0.075 | NA | NA |
| BRAF | nilotinib | 0.0823341 | 0.8522061 | 0.082 | NA | NA |
| ZRSR2 | nilotinib | 0.0823935 | 0.8522061 | 0.082 | NA | NA |
| MAP2K1 | nilotinib | 0.0869990 | 0.8522061 | 0.087 | NA | NA |
| CBLB | nilotinib | 0.0920561 | 0.8522061 | 0.092 | NA | NA |
| NCOA2 | nilotinib | 0.0971203 | 0.8522061 | 0.097 | NA | NA |
| G6PD | nilotinib | 0.0978349 | 0.8522061 | 0.098 | NA | NA |
| PIGA | nilotinib | 0.1007178 | 0.8522061 | 0.101 | NA | NA |
| AKT1 | nilotinib | 0.1319214 | 0.8522061 | 0.132 | NA | NA |
| CD274 | nilotinib | 0.1500406 | 0.8522061 | 0.150 | NA | NA |
| EML4 | nilotinib | 0.1557059 | 0.8522061 | 0.156 | NA | NA |
| ERBB4 | nilotinib | 0.1674099 | 0.8522061 | 0.167 | NA | NA |
| GNA11 | nilotinib | 0.1690832 | 0.8522061 | 0.169 | NA | NA |
| DPYD | nilotinib | 0.1716871 | 0.8522061 | 0.172 | NA | NA |
| CDC73 | nilotinib | 0.1737485 | 0.8522061 | 0.174 | NA | NA |
| IDH2 | nilotinib | 0.1844993 | 0.8522061 | 0.184 | NA | NA |
| PHF6 | nilotinib | 0.1953337 | 0.8522061 | 0.195 | NA | NA |
| FBXW7 | nilotinib | 0.1956027 | 0.8522061 | 0.196 | NA | NA |
| EED | nilotinib | 0.1957988 | 0.8522061 | 0.196 | NA | NA |
| ATM | nilotinib | 0.1967220 | 0.8522061 | 0.197 | NA | NA |
| CEBPA | nilotinib | 0.1968300 | 0.8522061 | 0.197 | NA | NA |
| DNAJB1 | nilotinib | 0.2009226 | 0.8522061 | 0.201 | NA | NA |
| IKZF1 | nilotinib | 0.2030879 | 0.8522061 | 0.203 | NA | NA |
| JAK3 | nilotinib | 0.2106747 | 0.8522061 | 0.211 | NA | NA |
| CDK6 | nilotinib | 0.2163351 | 0.8522061 | 0.216 | NA | NA |
| CALR | nilotinib | 0.2199033 | 0.8522061 | 0.220 | NA | NA |
| PRPF8 | nilotinib | 0.2273928 | 0.8522061 | 0.227 | NA | NA |
| ERBB2 | nilotinib | 0.2469369 | 0.8522061 | 0.247 | NA | NA |
| FANCL | nilotinib | 0.2544008 | 0.8522061 | 0.254 | NA | NA |
| PTEN | nilotinib | 0.2586912 | 0.8522061 | 0.259 | NA | NA |
| PDGFB | nilotinib | 0.2614178 | 0.8522061 | 0.261 | NA | NA |
| GNB1 | nilotinib | 0.2703894 | 0.8522061 | 0.270 | NA | NA |
| CRLF2 | nilotinib | 0.2819017 | 0.8522061 | 0.282 | NA | NA |
| RPL10 | nilotinib | 0.2850268 | 0.8522061 | 0.285 | NA | NA |
| KRAS | nilotinib | 0.2905710 | 0.8522061 | 0.291 | NA | NA |
| IDH1 | nilotinib | 0.2908172 | 0.8522061 | 0.291 | NA | NA |
| SETBP1 | nilotinib | 0.2960817 | 0.8522061 | 0.296 | NA | NA |
| PIK3CA | nilotinib | 0.2965860 | 0.8522061 | 0.297 | NA | NA |
| DDIT3 | nilotinib | 0.3025069 | 0.8522061 | 0.303 | NA | NA |
| CDK4 | nilotinib | 0.3095790 | 0.8522061 | 0.310 | NA | NA |
| SH2B3 | nilotinib | 0.3095790 | 0.8522061 | 0.310 | NA | NA |
| SMC3 | nilotinib | 0.3146584 | 0.8522061 | 0.315 | NA | NA |
| GATA1 | nilotinib | 0.3176333 | 0.8522061 | 0.318 | NA | NA |
| JAK2 | nilotinib | 0.3242397 | 0.8522061 | 0.324 | NA | NA |
| STAT3 | nilotinib | 0.3252695 | 0.8522061 | 0.325 | NA | NA |
| FGFR2 | selumetinib | 0.2084067 | 0.8531649 | 0.20841 | NA | NA |
| FGFR3 | erlotinib | 0.5057821 | 0.8604865 | 0.506 | NA | NA |
| CDK4 | irinotecan | 0.0868856 | 0.8671396 | 0.0869 | NA | NA |
| FGFR2 | irinotecan | 0.0873862 | 0.8671396 | 0.0874 | NA | NA |
| AKT1 | irinotecan | 0.0995560 | 0.8671396 | 0.0996 | NA | NA |
| CDC73 | irinotecan | 0.1207285 | 0.8671396 | 0.1207 | NA | NA |
| BRAF | irinotecan | 0.1223433 | 0.8671396 | 0.1223 | NA | NA |
| EML4 | irinotecan | 0.1225636 | 0.8671396 | 0.1226 | NA | NA |
| ATM | irinotecan | 0.1329381 | 0.8671396 | 0.1329 | NA | NA |
| GNB1 | irinotecan | 0.1580732 | 0.8671396 | 0.1581 | NA | NA |
| ERBB4 | irinotecan | 0.1615181 | 0.8671396 | 0.1615 | NA | NA |
| ESR1 | irinotecan | 0.1628356 | 0.8671396 | 0.1628 | NA | NA |
| CTLA4 | irinotecan | 0.1702373 | 0.8671396 | 0.1702 | NA | NA |
| TPMT | irinotecan | 0.1771488 | 0.8671396 | 0.1771 | NA | NA |
| PAX5 | irinotecan | 0.1910949 | 0.8671396 | 0.1911 | NA | NA |
| IKZF1 | irinotecan | 0.1945005 | 0.8671396 | 0.1945 | NA | NA |
| CD79B | irinotecan | 0.1953386 | 0.8671396 | 0.1953 | NA | NA |
| PDGFRB | irinotecan | 0.2131484 | 0.8671396 | 0.2131 | NA | NA |
| EGFR | irinotecan | 0.2306603 | 0.8671396 | 0.2307 | NA | NA |
| CREBBP | irinotecan | 0.2415640 | 0.8671396 | 0.2416 | NA | NA |
| MGMT | irinotecan | 0.2444998 | 0.8671396 | 0.2445 | NA | NA |
| BRCA2 | irinotecan | 0.2519045 | 0.8671396 | 0.2519 | NA | NA |
| SETBP1 | irinotecan | 0.2535542 | 0.8671396 | 0.2536 | NA | NA |
| PRPF40B | irinotecan | 0.2545052 | 0.8671396 | 0.2545 | NA | NA |
| DPYD | irinotecan | 0.2565617 | 0.8671396 | 0.2566 | NA | NA |
| U2AF1 | irinotecan | 0.2686219 | 0.8671396 | 0.2686 | NA | NA |
| TP53 | irinotecan | 0.2699212 | 0.8671396 | 0.2699 | NA | NA |
| DNMT3A | irinotecan | 0.2699431 | 0.8671396 | 0.2699 | NA | NA |
| IL7R | irinotecan | 0.2748197 | 0.8671396 | 0.2748 | NA | NA |
| ETV6 | irinotecan | 0.2759762 | 0.8671396 | 0.2760 | NA | NA |
| GNAS | irinotecan | 0.2798045 | 0.8671396 | 0.2798 | NA | NA |
| GNA11 | irinotecan | 0.2837623 | 0.8671396 | 0.2838 | NA | NA |
| STAG2 | irinotecan | 0.2896816 | 0.8671396 | 0.2897 | NA | NA |
| RIT1 | irinotecan | 0.2916381 | 0.8671396 | 0.2916 | NA | NA |
| GATA3 | irinotecan | 0.2950313 | 0.8671396 | 0.2950 | NA | NA |
| CALR | irinotecan | 0.3188346 | 0.8671396 | 0.3188 | NA | NA |
| PIK3CA | irinotecan | 0.3207286 | 0.8671396 | 0.3207 | NA | NA |
| CYP19A1 | irinotecan | 0.3281397 | 0.8671396 | 0.3281 | NA | NA |
| RAD21 | irinotecan | 0.3328997 | 0.8671396 | 0.3329 | NA | NA |
| STAT3 | irinotecan | 0.3391154 | 0.8671396 | 0.3391 | NA | NA |
| PAX8 | irinotecan | 0.3425029 | 0.8671396 | 0.3425 | NA | NA |
| GATA2 | irinotecan | 0.3492471 | 0.8671396 | 0.3492 | NA | NA |
| SF1 | irinotecan | 0.3571830 | 0.8671396 | 0.3572 | NA | NA |
| MET | irinotecan | 0.3595819 | 0.8671396 | 0.3596 | NA | NA |
| MYD88 | irinotecan | 0.3660517 | 0.8671396 | 0.3661 | NA | NA |
| AR | irinotecan | 0.3668667 | 0.8671396 | 0.3669 | NA | NA |
| FLCN | lapatinib | 0.2981455 | 0.8679347 | 0.298 | NA | NA |
| CD79B | nilotinib | 0.3432244 | 0.8696666 | 0.343 | NA | NA |
| ASXL1 | nilotinib | 0.3452112 | 0.8696666 | 0.345 | NA | NA |
| GATA1 | lapatinib | 0.3258106 | 0.8729795 | 0.326 | NA | NA |
| NCOA2 | lapatinib | 0.3280718 | 0.8729795 | 0.328 | NA | NA |
| STAT3 | lapatinib | 0.3335387 | 0.8729795 | 0.334 | NA | NA |
| EZH2 | lapatinib | 0.3363420 | 0.8729795 | 0.336 | NA | NA |
| IDH1 | lapatinib | 0.3512958 | 0.8729795 | 0.351 | NA | NA |
| FGFR1 | lapatinib | 0.3538617 | 0.8729795 | 0.354 | NA | NA |
| EML4 | lapatinib | 0.3576785 | 0.8729795 | 0.358 | NA | NA |
| SMO | lapatinib | 0.3610953 | 0.8729795 | 0.361 | NA | NA |
| RPL10 | lapatinib | 0.3697756 | 0.8729795 | 0.370 | NA | NA |
| KRAS | lapatinib | 0.3717079 | 0.8729795 | 0.372 | NA | NA |
| BTK | lapatinib | 0.3783216 | 0.8729795 | 0.378 | NA | NA |
| MAP2K1 | lapatinib | 0.3798461 | 0.8729795 | 0.380 | NA | NA |
| EGF | nilotinib | 0.3535275 | 0.8738133 | 0.354 | NA | NA |
| CYP19A1 | nilotinib | 0.3614358 | 0.8768164 | 0.361 | NA | NA |
| AKT3 | lapatinib | 0.3897579 | 0.8803152 | 0.390 | NA | NA |
| MAP2K1 | erlotinib | 0.5270899 | 0.8852407 | 0.527 | NA | NA |
| MET | nilotinib | 0.3749787 | 0.8877627 | 0.375 | NA | NA |
| SRSF2 | nilotinib | 0.3795016 | 0.8877627 | 0.380 | NA | NA |
| ESR1 | erlotinib | 0.5463206 | 0.8939785 | 0.546 | NA | NA |
| VHL | erlotinib | 0.5488405 | 0.8939785 | 0.549 | NA | NA |
| FLCN | erlotinib | 0.5527653 | 0.8939785 | 0.553 | NA | NA |
| HRAS | lapatinib | 0.4223510 | 0.9047072 | 0.422 | NA | NA |
| MPL | lapatinib | 0.4272603 | 0.9047072 | 0.427 | NA | NA |
| WHSC1 | lapatinib | 0.4278387 | 0.9047072 | 0.428 | NA | NA |
| PIK3CA | lapatinib | 0.4324195 | 0.9047072 | 0.432 | NA | NA |
| ABL1 | lapatinib | 0.4453225 | 0.9047072 | 0.445 | NA | NA |
| GNB1 | lapatinib | 0.4579231 | 0.9047072 | 0.458 | NA | NA |
| MYD88 | lapatinib | 0.4587151 | 0.9047072 | 0.459 | NA | NA |
| ALK | lapatinib | 0.4609038 | 0.9047072 | 0.461 | NA | NA |
| PAX8 | lapatinib | 0.4777998 | 0.9047072 | 0.478 | NA | NA |
| GNA11 | lapatinib | 0.4911808 | 0.9047072 | 0.491 | NA | NA |
| DPYD | lapatinib | 0.4951753 | 0.9047072 | 0.495 | NA | NA |
| CTCF | lapatinib | 0.5174017 | 0.9047072 | 0.517 | NA | NA |
| BRCA1 | lapatinib | 0.5346294 | 0.9047072 | 0.535 | NA | NA |
| GATA3 | lapatinib | 0.5384377 | 0.9047072 | 0.538 | NA | NA |
| IL7R | lapatinib | 0.5439112 | 0.9047072 | 0.544 | NA | NA |
| IKZF1 | lapatinib | 0.5493652 | 0.9047072 | 0.549 | NA | NA |
| ATM | lapatinib | 0.5550964 | 0.9047072 | 0.555 | NA | NA |
| MET | lapatinib | 0.5678884 | 0.9047072 | 0.568 | NA | NA |
| EGF | lapatinib | 0.5756426 | 0.9047072 | 0.576 | NA | NA |
| GATA2 | lapatinib | 0.5776923 | 0.9047072 | 0.578 | NA | NA |
| PDGFRB | lapatinib | 0.5810825 | 0.9047072 | 0.581 | NA | NA |
| CTNNB1 | lapatinib | 0.5823848 | 0.9047072 | 0.582 | NA | NA |
| JAK1 | lapatinib | 0.5848719 | 0.9047072 | 0.585 | NA | NA |
| UGT1A1 | lapatinib | 0.5880643 | 0.9047072 | 0.588 | NA | NA |
| RIT1 | lapatinib | 0.5908467 | 0.9047072 | 0.591 | NA | NA |
| GNAS | lapatinib | 0.5958805 | 0.9047072 | 0.596 | NA | NA |
| CDK4 | lapatinib | 0.5976694 | 0.9047072 | 0.598 | NA | NA |
| SETD2 | lapatinib | 0.6015271 | 0.9047072 | 0.602 | NA | NA |
| AKT1 | lapatinib | 0.6019637 | 0.9047072 | 0.602 | NA | NA |
| CDKN2A | lapatinib | 0.6158264 | 0.9047072 | 0.616 | NA | NA |
| RUNX1 | lapatinib | 0.6166705 | 0.9047072 | 0.617 | NA | NA |
| JAK3 | lapatinib | 0.6237232 | 0.9047072 | 0.624 | NA | NA |
| G6PD | lapatinib | 0.6332410 | 0.9047072 | 0.633 | NA | NA |
| SETBP1 | lapatinib | 0.6353669 | 0.9047072 | 0.635 | NA | NA |
| NRAS | irinotecan | 0.3909888 | 0.9076525 | 0.3910 | NA | NA |
| PAX5 | nilotinib | 0.3950175 | 0.9078473 | 0.395 | NA | NA |
| SMC1A | lapatinib | 0.6516111 | 0.9092433 | 0.652 | NA | NA |
| CBL | lapatinib | 0.6524341 | 0.9092433 | 0.652 | NA | NA |
| CYP19A1 | erlotinib | 0.5725012 | 0.9146055 | 0.573 | NA | NA |
| PRPF40B | erlotinib | 0.5871846 | 0.9169446 | 0.587 | NA | NA |
| IL7R | erlotinib | 0.5879645 | 0.9169446 | 0.588 | NA | NA |
| AR | lapatinib | 0.6705630 | 0.9246710 | 0.671 | NA | NA |
| GNAQ | nilotinib | 0.4094761 | 0.9248512 | 0.409 | NA | NA |
| ALK | irinotecan | 0.4159284 | 0.9343904 | 0.4159 | NA | NA |
| MAP2K1 | irinotecan | 0.4180667 | 0.9343904 | 0.4181 | NA | NA |
| VHL | irinotecan | 0.4240695 | 0.9343904 | 0.4241 | NA | NA |
| CBL | erlotinib | 0.6066026 | 0.9348817 | 0.607 | NA | NA |
| FANCL | selumetinib | 0.2375039 | 0.9379023 | 0.23750 | NA | NA |
| NOTCH1 | selumetinib | 0.2510449 | 0.9379023 | 0.25104 | NA | NA |
| VHL | selumetinib | 0.2554789 | 0.9379023 | 0.25548 | NA | NA |
| PAX8 | selumetinib | 0.2784348 | 0.9379023 | 0.27843 | NA | NA |
| SMC3 | selumetinib | 0.2800304 | 0.9379023 | 0.28003 | NA | NA |
| GATA1 | selumetinib | 0.2877975 | 0.9379023 | 0.28780 | NA | NA |
| RIT1 | selumetinib | 0.2890366 | 0.9379023 | 0.28904 | NA | NA |
| NT5C2 | selumetinib | 0.2993317 | 0.9379023 | 0.29933 | NA | NA |
| TSC1 | selumetinib | 0.3026265 | 0.9379023 | 0.30263 | NA | NA |
| CBL | selumetinib | 0.3063751 | 0.9379023 | 0.30638 | NA | NA |
| RET | selumetinib | 0.3162948 | 0.9379023 | 0.31629 | NA | NA |
| MAP2K2 | selumetinib | 0.3219772 | 0.9379023 | 0.32198 | NA | NA |
| GATA2 | selumetinib | 0.3395397 | 0.9379023 | 0.33954 | NA | NA |
| GATA3 | selumetinib | 0.3459306 | 0.9379023 | 0.34593 | NA | NA |
| BTK | selumetinib | 0.3507388 | 0.9379023 | 0.35074 | NA | NA |
| CYP19A1 | selumetinib | 0.3657355 | 0.9379023 | 0.36574 | NA | NA |
| CEBPA | selumetinib | 0.3714072 | 0.9379023 | 0.37141 | NA | NA |
| TP53 | selumetinib | 0.3730400 | 0.9379023 | 0.37304 | NA | NA |
| CDK4 | selumetinib | 0.3739875 | 0.9379023 | 0.37399 | NA | NA |
| CD79B | selumetinib | 0.3789936 | 0.9379023 | 0.37899 | NA | NA |
| SF3B1 | selumetinib | 0.3794567 | 0.9379023 | 0.37946 | NA | NA |
| PIGA | lapatinib | 0.6899301 | 0.9387284 | 0.690 | NA | NA |
| CYP19A1 | lapatinib | 0.6950890 | 0.9387284 | 0.695 | NA | NA |
| SMC1A | selumetinib | 0.3873961 | 0.9397942 | 0.38740 | NA | NA |
| CBLB | selumetinib | 0.3957166 | 0.9425251 | 0.39572 | NA | NA |
| CDK6 | selumetinib | 0.4197911 | 0.9453281 | 0.41979 | NA | NA |
| RAD21 | selumetinib | 0.4202363 | 0.9453281 | 0.42024 | NA | NA |
| KIT | selumetinib | 0.4291048 | 0.9453281 | 0.42910 | NA | NA |
| SETBP1 | selumetinib | 0.4352803 | 0.9453281 | 0.43528 | NA | NA |
| GNB1 | selumetinib | 0.4390316 | 0.9453281 | 0.43903 | NA | NA |
| FBXW7 | selumetinib | 0.4403523 | 0.9453281 | 0.44035 | NA | NA |
| ESR1 | selumetinib | 0.4556101 | 0.9453281 | 0.45561 | NA | NA |
| CD274 | selumetinib | 0.4672104 | 0.9453281 | 0.46721 | NA | NA |
| CTLA4 | selumetinib | 0.4717193 | 0.9453281 | 0.47172 | NA | NA |
| STAT3 | selumetinib | 0.4741982 | 0.9453281 | 0.47420 | NA | NA |
| CRLF2 | selumetinib | 0.4762722 | 0.9453281 | 0.47627 | NA | NA |
| ZRSR2 | lapatinib | 0.7127565 | 0.9527664 | 0.713 | NA | NA |
| TSC1 | erlotinib | 0.6505989 | 0.9563686 | 0.651 | NA | NA |
| GATA1 | erlotinib | 0.6580401 | 0.9563686 | 0.658 | NA | NA |
| GNB1 | erlotinib | 0.6685175 | 0.9563686 | 0.669 | NA | NA |
| DPYD | erlotinib | 0.6840148 | 0.9563686 | 0.684 | NA | NA |
| BTK | erlotinib | 0.6873166 | 0.9563686 | 0.687 | NA | NA |
| IKZF1 | erlotinib | 0.7003041 | 0.9563686 | 0.700 | NA | NA |
| NRAS | erlotinib | 0.7042626 | 0.9563686 | 0.704 | NA | NA |
| RIT1 | erlotinib | 0.7055740 | 0.9563686 | 0.706 | NA | NA |
| WHSC1 | erlotinib | 0.7063712 | 0.9563686 | 0.706 | NA | NA |
| PTPN11 | erlotinib | 0.7104107 | 0.9563686 | 0.710 | NA | NA |
| SSX1 | erlotinib | 0.7213924 | 0.9563686 | 0.721 | NA | NA |
| ATM | erlotinib | 0.7248163 | 0.9563686 | 0.725 | NA | NA |
| JAK3 | erlotinib | 0.7290446 | 0.9563686 | 0.729 | NA | NA |
| PTCH1 | erlotinib | 0.7302464 | 0.9563686 | 0.730 | NA | NA |
| EZH2 | erlotinib | 0.7344706 | 0.9563686 | 0.734 | NA | NA |
| RUNX1 | erlotinib | 0.7408697 | 0.9563686 | 0.741 | NA | NA |
| JAK1 | erlotinib | 0.7446534 | 0.9563686 | 0.745 | NA | NA |
| BRCA2 | nilotinib | 0.4329522 | 0.9569263 | 0.433 | NA | NA |
| DNMT3A | nilotinib | 0.4393202 | 0.9569263 | 0.439 | NA | NA |
| RAD21 | nilotinib | 0.4455916 | 0.9569263 | 0.446 | NA | NA |
| SH2B3 | lapatinib | 0.7233868 | 0.9572087 | 0.723 | NA | NA |
| MPL | nilotinib | 0.4540395 | 0.9593416 | 0.454 | NA | NA |
| PDGFRB | nilotinib | 0.4795241 | 0.9607015 | 0.480 | NA | NA |
| NT5C2 | nilotinib | 0.4985874 | 0.9607015 | 0.499 | NA | NA |
| ESR1 | nilotinib | 0.5209092 | 0.9607015 | 0.521 | NA | NA |
| NPM1 | nilotinib | 0.5225901 | 0.9607015 | 0.523 | NA | NA |
| ETV6 | nilotinib | 0.5231112 | 0.9607015 | 0.523 | NA | NA |
| VHL | nilotinib | 0.5249231 | 0.9607015 | 0.525 | NA | NA |
| TP53 | nilotinib | 0.5288472 | 0.9607015 | 0.529 | NA | NA |
| CDKN2A | nilotinib | 0.5300461 | 0.9607015 | 0.530 | NA | NA |
| PRPF40B | nilotinib | 0.5310239 | 0.9607015 | 0.531 | NA | NA |
| NOTCH2 | nilotinib | 0.5393383 | 0.9607015 | 0.539 | NA | NA |
| PDCD1 | nilotinib | 0.5606283 | 0.9607015 | 0.561 | NA | NA |
| SMO | nilotinib | 0.5711686 | 0.9607015 | 0.571 | NA | NA |
| CTNNB1 | nilotinib | 0.5810417 | 0.9607015 | 0.581 | NA | NA |
| CSF3R | nilotinib | 0.5848095 | 0.9607015 | 0.585 | NA | NA |
| SSX1 | nilotinib | 0.5863196 | 0.9607015 | 0.586 | NA | NA |
| FLT3 | nilotinib | 0.5913464 | 0.9607015 | 0.591 | NA | NA |
| RET | nilotinib | 0.5975829 | 0.9607015 | 0.598 | NA | NA |
| NRAS | nilotinib | 0.5977193 | 0.9607015 | 0.598 | NA | NA |
| CBL | nilotinib | 0.6047466 | 0.9607015 | 0.605 | NA | NA |
| PTPN11 | nilotinib | 0.6063462 | 0.9607015 | 0.606 | NA | NA |
| SF1 | nilotinib | 0.6086888 | 0.9607015 | 0.609 | NA | NA |
| BTK | irinotecan | 0.4499106 | 0.9616095 | 0.4499 | NA | NA |
| CD274 | irinotecan | 0.4598390 | 0.9616095 | 0.4598 | NA | NA |
| DNAJB1 | irinotecan | 0.4725298 | 0.9616095 | 0.4725 | NA | NA |
| SMC3 | irinotecan | 0.4778543 | 0.9616095 | 0.4779 | NA | NA |
| PHF6 | irinotecan | 0.4809070 | 0.9616095 | 0.4809 | NA | NA |
| ROS1 | irinotecan | 0.4834670 | 0.9616095 | 0.4835 | NA | NA |
| NOTCH1 | irinotecan | 0.5083990 | 0.9616095 | 0.5084 | NA | NA |
| PDGFB | irinotecan | 0.5117862 | 0.9616095 | 0.5118 | NA | NA |
| TET2 | irinotecan | 0.5145990 | 0.9616095 | 0.5146 | NA | NA |
| PTPN11 | irinotecan | 0.5165017 | 0.9616095 | 0.5165 | NA | NA |
| IDH1 | irinotecan | 0.5177897 | 0.9616095 | 0.5178 | NA | NA |
| HRAS | selumetinib | 0.4931995 | 0.9643155 | 0.49320 | NA | NA |
| ERBB4 | erlotinib | 0.7781237 | 0.9658067 | 0.778 | NA | NA |
| G6PD | erlotinib | 0.7787902 | 0.9658067 | 0.779 | NA | NA |
| FGFR1 | erlotinib | 0.7800078 | 0.9658067 | 0.780 | NA | NA |
| KMT2A | erlotinib | 0.7907716 | 0.9658067 | 0.791 | NA | NA |
| GNAS | erlotinib | 0.7962137 | 0.9658067 | 0.796 | NA | NA |
| PAX8 | erlotinib | 0.7962376 | 0.9658067 | 0.796 | NA | NA |
| TSC1 | lapatinib | 0.7401698 | 0.9696225 | 0.740 | NA | NA |
| PRPF40B | lapatinib | 0.7523713 | 0.9698092 | 0.752 | NA | NA |
| CDC73 | lapatinib | 0.7574639 | 0.9698092 | 0.757 | NA | NA |
| FGFR3 | lapatinib | 0.7703491 | 0.9698092 | 0.770 | NA | NA |
| MAP2K2 | lapatinib | 0.7714479 | 0.9698092 | 0.771 | NA | NA |
| SMC3 | lapatinib | 0.7862153 | 0.9698092 | 0.786 | NA | NA |
| PTCH1 | lapatinib | 0.7871784 | 0.9698092 | 0.787 | NA | NA |
| EGFR | lapatinib | 0.7947247 | 0.9698092 | 0.795 | NA | NA |
| ERBB4 | lapatinib | 0.8042029 | 0.9698092 | 0.804 | NA | NA |
| IDH2 | lapatinib | 0.8145125 | 0.9698092 | 0.815 | NA | NA |
| SSX1 | lapatinib | 0.8176005 | 0.9698092 | 0.818 | NA | NA |
| CD79B | lapatinib | 0.8217468 | 0.9698092 | 0.822 | NA | NA |
| MPL | erlotinib | 0.8134653 | 0.9720100 | 0.813 | NA | NA |
| UGT1A1 | erlotinib | 0.8238031 | 0.9720100 | 0.824 | NA | NA |
| PDGFRB | erlotinib | 0.8279937 | 0.9720100 | 0.828 | NA | NA |
| FANCL | erlotinib | 0.8310314 | 0.9720100 | 0.831 | NA | NA |
| IDH2 | irinotecan | 0.5383687 | 0.9726121 | 0.5384 | NA | NA |
| SRSF2 | irinotecan | 0.5486376 | 0.9726121 | 0.5486 | NA | NA |
| KMT2A | irinotecan | 0.5662482 | 0.9726121 | 0.5662 | NA | NA |
| CEBPA | irinotecan | 0.5694611 | 0.9726121 | 0.5695 | NA | NA |
| PIGA | irinotecan | 0.5810477 | 0.9726121 | 0.5810 | NA | NA |
| PDGFRA | irinotecan | 0.5925752 | 0.9726121 | 0.5926 | NA | NA |
| NT5C2 | irinotecan | 0.5962588 | 0.9726121 | 0.5963 | NA | NA |
| JAK3 | irinotecan | 0.5999452 | 0.9726121 | 0.5999 | NA | NA |
| TSC1 | irinotecan | 0.6014923 | 0.9726121 | 0.6015 | NA | NA |
| ERBB2 | irinotecan | 0.6286426 | 0.9726121 | 0.6286 | NA | NA |
| PML | irinotecan | 0.6294330 | 0.9726121 | 0.6294 | NA | NA |
| FANCL | irinotecan | 0.6327514 | 0.9726121 | 0.6328 | NA | NA |
| CXCR4 | irinotecan | 0.6348669 | 0.9726121 | 0.6349 | NA | NA |
| RET | irinotecan | 0.6389716 | 0.9726121 | 0.6390 | NA | NA |
| AKT3 | irinotecan | 0.6506008 | 0.9726121 | 0.6506 | NA | NA |
| WHSC1 | irinotecan | 0.6542440 | 0.9726121 | 0.6542 | NA | NA |
| PDCD1 | irinotecan | 0.6545590 | 0.9726121 | 0.6546 | NA | NA |
| ABL1 | irinotecan | 0.6660281 | 0.9726121 | 0.6660 | NA | NA |
| CTNNB1 | irinotecan | 0.6690072 | 0.9726121 | 0.6690 | NA | NA |
| EZH2 | irinotecan | 0.6733468 | 0.9726121 | 0.6733 | NA | NA |
| NT5C2 | erlotinib | 0.8425719 | 0.9767869 | 0.843 | NA | NA |
| PRPF8 | irinotecan | 0.7015023 | 0.9775516 | 0.7015 | NA | NA |
| PTCH1 | irinotecan | 0.7162618 | 0.9775516 | 0.7163 | NA | NA |
| SF3B1 | irinotecan | 0.7173061 | 0.9775516 | 0.7173 | NA | NA |
| CBLB | irinotecan | 0.7342163 | 0.9775516 | 0.7342 | NA | NA |
| GATA1 | irinotecan | 0.7510689 | 0.9775516 | 0.7511 | NA | NA |
| RPL10 | irinotecan | 0.7548056 | 0.9775516 | 0.7548 | NA | NA |
| SMC1A | irinotecan | 0.7580493 | 0.9775516 | 0.7580 | NA | NA |
| FGFR3 | irinotecan | 0.7590167 | 0.9775516 | 0.7590 | NA | NA |
| CRLF2 | irinotecan | 0.7651322 | 0.9775516 | 0.7651 | NA | NA |
| SSX1 | irinotecan | 0.7716424 | 0.9775516 | 0.7716 | NA | NA |
| HRAS | irinotecan | 0.7830688 | 0.9775516 | 0.7831 | NA | NA |
| RUNX1 | irinotecan | 0.7975944 | 0.9775516 | 0.7976 | NA | NA |
| SMO | irinotecan | 0.7988480 | 0.9775516 | 0.7988 | NA | NA |
| AKT2 | irinotecan | 0.8069935 | 0.9775516 | 0.8070 | NA | NA |
| CSF3R | irinotecan | 0.8191014 | 0.9775516 | 0.8191 | NA | NA |
| XPO1 | irinotecan | 0.8196641 | 0.9775516 | 0.8197 | NA | NA |
| BRCA1 | irinotecan | 0.8210965 | 0.9775516 | 0.8211 | NA | NA |
| G6PD | irinotecan | 0.8254252 | 0.9775516 | 0.8254 | NA | NA |
| UGT1A1 | irinotecan | 0.8309879 | 0.9775516 | 0.8310 | NA | NA |
| NCOA2 | irinotecan | 0.8517003 | 0.9775516 | 0.8517 | NA | NA |
| KIT | irinotecan | 0.8862231 | 0.9775516 | 0.8862 | NA | NA |
| FGFR1 | irinotecan | 0.8871126 | 0.9775516 | 0.8871 | NA | NA |
| NPM1 | irinotecan | 0.8930026 | 0.9775516 | 0.8930 | NA | NA |
| CBL | irinotecan | 0.9079854 | 0.9775516 | 0.9080 | NA | NA |
| ASXL1 | irinotecan | 0.9089550 | 0.9775516 | 0.9090 | NA | NA |
| FLCN | irinotecan | 0.9219343 | 0.9775516 | 0.9219 | NA | NA |
| CTCF | irinotecan | 0.9262120 | 0.9775516 | 0.9262 | NA | NA |
| EGF | irinotecan | 0.9294390 | 0.9775516 | 0.9294 | NA | NA |
| CDK6 | irinotecan | 0.9369407 | 0.9775516 | 0.9369 | NA | NA |
| BCOR | irinotecan | 0.9384232 | 0.9775516 | 0.9384 | NA | NA |
| PTEN | irinotecan | 0.9404034 | 0.9775516 | 0.9404 | NA | NA |
| SH2B3 | irinotecan | 0.9413890 | 0.9775516 | 0.9414 | NA | NA |
| MPL | irinotecan | 0.9419762 | 0.9775516 | 0.9420 | NA | NA |
| MDM2 | irinotecan | 0.9444299 | 0.9775516 | 0.9444 | NA | NA |
| WT1 | irinotecan | 0.9470140 | 0.9775516 | 0.9470 | NA | NA |
| MAP2K2 | irinotecan | 0.9474730 | 0.9775516 | 0.9475 | NA | NA |
| DDIT3 | lapatinib | 0.8377397 | 0.9777206 | 0.838 | NA | NA |
| KMT2A | lapatinib | 0.8454470 | 0.9777206 | 0.845 | NA | NA |
| FLT3 | lapatinib | 0.8614733 | 0.9777206 | 0.861 | NA | NA |
| BCOR | lapatinib | 0.8638970 | 0.9777206 | 0.864 | NA | NA |
| NT5C2 | lapatinib | 0.8753678 | 0.9777206 | 0.875 | NA | NA |
| BCORL1 | lapatinib | 0.8806185 | 0.9777206 | 0.881 | NA | NA |
| STAG2 | lapatinib | 0.8834116 | 0.9777206 | 0.883 | NA | NA |
| PRPF8 | lapatinib | 0.8893234 | 0.9777206 | 0.889 | NA | NA |
| TPMT | lapatinib | 0.9089736 | 0.9777206 | 0.909 | NA | NA |
| CDK6 | lapatinib | 0.9113470 | 0.9777206 | 0.911 | NA | NA |
| PAX5 | lapatinib | 0.9176528 | 0.9777206 | 0.918 | NA | NA |
| AKT2 | lapatinib | 0.9180125 | 0.9777206 | 0.918 | NA | NA |
| ABL1 | erlotinib | 0.8522490 | 0.9793387 | 0.852 | NA | NA |
| TET2 | erlotinib | 0.8613977 | 0.9812444 | 0.861 | NA | NA |
| BCORL1 | irinotecan | 0.9680876 | 0.9827803 | 0.9681 | NA | NA |
| ERBB3 | irinotecan | 0.9705439 | 0.9827803 | 0.9705 | NA | NA |
| CDKN2A | irinotecan | 0.9752204 | 0.9827803 | 0.9752 | NA | NA |
| CTCF | nilotinib | 0.6405142 | 0.9855023 | 0.641 | NA | NA |
| KIT | nilotinib | 0.6606331 | 0.9855023 | 0.661 | NA | NA |
| TPMT | nilotinib | 0.6679929 | 0.9855023 | 0.668 | NA | NA |
| JAK1 | nilotinib | 0.6683405 | 0.9855023 | 0.668 | NA | NA |
| AKT3 | nilotinib | 0.6789529 | 0.9855023 | 0.679 | NA | NA |
| FGFR1 | nilotinib | 0.6796758 | 0.9855023 | 0.680 | NA | NA |
| ROS1 | nilotinib | 0.6819122 | 0.9855023 | 0.682 | NA | NA |
| MYD88 | nilotinib | 0.6912056 | 0.9855023 | 0.691 | NA | NA |
| TSC2 | nilotinib | 0.6921085 | 0.9855023 | 0.692 | NA | NA |
| CDKN2A | erlotinib | 0.8747139 | 0.9864676 | 0.875 | NA | NA |
| STAT3 | erlotinib | 0.8844399 | 0.9864676 | 0.884 | NA | NA |
| MYD88 | erlotinib | 0.8885739 | 0.9864676 | 0.889 | NA | NA |
| EML4 | selumetinib | 0.5261206 | 0.9881245 | 0.52612 | NA | NA |
| AKT2 | selumetinib | 0.5332426 | 0.9881245 | 0.53324 | NA | NA |
| FGFR3 | selumetinib | 0.5504813 | 0.9881245 | 0.55048 | NA | NA |
| CREBBP | selumetinib | 0.5551165 | 0.9881245 | 0.55512 | NA | NA |
| PTPN11 | selumetinib | 0.5722801 | 0.9881245 | 0.57228 | NA | NA |
| EGFR | selumetinib | 0.5763443 | 0.9881245 | 0.57634 | NA | NA |
| JAK3 | selumetinib | 0.5791652 | 0.9881245 | 0.57917 | NA | NA |
| CALR | selumetinib | 0.5793494 | 0.9881245 | 0.57935 | NA | NA |
| MAP2K1 | selumetinib | 0.5850648 | 0.9881245 | 0.58506 | NA | NA |
| TSC2 | selumetinib | 0.6111574 | 0.9881245 | 0.61116 | NA | NA |
| ATM | selumetinib | 0.6349288 | 0.9881245 | 0.63493 | NA | NA |
| CDC73 | selumetinib | 0.6511899 | 0.9881245 | 0.65119 | NA | NA |
| MET | selumetinib | 0.6524774 | 0.9881245 | 0.65248 | NA | NA |
| U2AF1 | selumetinib | 0.6577081 | 0.9881245 | 0.65771 | NA | NA |
| IKZF1 | selumetinib | 0.6611150 | 0.9881245 | 0.66111 | NA | NA |
| ABL1 | selumetinib | 0.6628862 | 0.9881245 | 0.66289 | NA | NA |
| PDGFRB | selumetinib | 0.6645199 | 0.9881245 | 0.66452 | NA | NA |
| PRPF40B | selumetinib | 0.6689523 | 0.9881245 | 0.66895 | NA | NA |
| MDM2 | selumetinib | 0.6727814 | 0.9881245 | 0.67278 | NA | NA |
| CTNNB1 | selumetinib | 0.6746071 | 0.9881245 | 0.67461 | NA | NA |
| EED | selumetinib | 0.6798049 | 0.9881245 | 0.67980 | NA | NA |
| FLCN | selumetinib | 0.6802253 | 0.9881245 | 0.68023 | NA | NA |
| EGF | selumetinib | 0.6802678 | 0.9881245 | 0.68027 | NA | NA |
| DPYD | selumetinib | 0.6868738 | 0.9881245 | 0.68687 | NA | NA |
| PDCD1 | selumetinib | 0.7186602 | 0.9881245 | 0.71866 | NA | NA |
| NOTCH2 | selumetinib | 0.7202092 | 0.9881245 | 0.72021 | NA | NA |
| DDIT3 | selumetinib | 0.7243926 | 0.9881245 | 0.72439 | NA | NA |
| MYD88 | selumetinib | 0.7246756 | 0.9881245 | 0.72468 | NA | NA |
| BCORL1 | selumetinib | 0.7333376 | 0.9881245 | 0.73334 | NA | NA |
| PIGA | selumetinib | 0.7421261 | 0.9881245 | 0.74213 | NA | NA |
| GNA11 | selumetinib | 0.7569104 | 0.9881245 | 0.75691 | NA | NA |
| NCOA2 | selumetinib | 0.7585886 | 0.9881245 | 0.75859 | NA | NA |
| PDGFB | selumetinib | 0.7634636 | 0.9881245 | 0.76346 | NA | NA |
| AR | selumetinib | 0.7836835 | 0.9881245 | 0.78368 | NA | NA |
| PHF6 | selumetinib | 0.7908963 | 0.9881245 | 0.79090 | NA | NA |
| SSX1 | selumetinib | 0.7987359 | 0.9881245 | 0.79874 | NA | NA |
| WT1 | selumetinib | 0.8117996 | 0.9881245 | 0.81180 | NA | NA |
| DNAJB1 | selumetinib | 0.8178008 | 0.9881245 | 0.81780 | NA | NA |
| ERBB2 | selumetinib | 0.8218228 | 0.9881245 | 0.82182 | NA | NA |
| ROS1 | selumetinib | 0.8271911 | 0.9881245 | 0.82719 | NA | NA |
| ALK | selumetinib | 0.8278795 | 0.9881245 | 0.82788 | NA | NA |
| FGFR1 | selumetinib | 0.8422202 | 0.9881245 | 0.84222 | NA | NA |
| ERBB4 | selumetinib | 0.8446106 | 0.9881245 | 0.84461 | NA | NA |
| FLT3 | selumetinib | 0.8527746 | 0.9881245 | 0.85277 | NA | NA |
| SETD2 | selumetinib | 0.8627670 | 0.9881245 | 0.86277 | NA | NA |
| RPL10 | selumetinib | 0.8658058 | 0.9881245 | 0.86581 | NA | NA |
| ERBB3 | selumetinib | 0.8669447 | 0.9881245 | 0.86694 | NA | NA |
| CTCF | selumetinib | 0.8706349 | 0.9881245 | 0.87063 | NA | NA |
| NPM1 | selumetinib | 0.8832243 | 0.9881245 | 0.88322 | NA | NA |
| UGT1A1 | selumetinib | 0.8917738 | 0.9881245 | 0.89177 | NA | NA |
| AKT1 | selumetinib | 0.9187209 | 0.9881245 | 0.91872 | NA | NA |
| PAX5 | selumetinib | 0.9213643 | 0.9881245 | 0.92136 | NA | NA |
| MGMT | selumetinib | 0.9254057 | 0.9881245 | 0.92541 | NA | NA |
| IL7R | selumetinib | 0.9287200 | 0.9881245 | 0.92872 | NA | NA |
| CXCR4 | selumetinib | 0.9335671 | 0.9881245 | 0.93357 | NA | NA |
| SF1 | selumetinib | 0.9388121 | 0.9881245 | 0.93881 | NA | NA |
| TET2 | selumetinib | 0.9390759 | 0.9881245 | 0.93908 | NA | NA |
| SH2B3 | selumetinib | 0.9448071 | 0.9881245 | 0.94481 | NA | NA |
| PML | selumetinib | 0.9504098 | 0.9881245 | 0.95041 | NA | NA |
| BRCA1 | selumetinib | 0.9592240 | 0.9888743 | 0.95922 | NA | NA |
| XPO1 | selumetinib | 0.9668163 | 0.9888743 | 0.96682 | NA | NA |
| GNAQ | selumetinib | 0.9752766 | 0.9888743 | 0.97528 | NA | NA |
| TPMT | selumetinib | 0.9863877 | 0.9888743 | 0.98639 | NA | NA |
| MYCN | selumetinib | 0.9888743 | 0.9888743 | 0.98887 | NA | NA |
| PHF6 | lapatinib | 0.9451994 | 0.9895734 | 0.945 | NA | NA |
| PTEN | lapatinib | 0.9516739 | 0.9895734 | 0.952 | NA | NA |
| ESR1 | lapatinib | 0.9641363 | 0.9895734 | 0.964 | NA | NA |
| CXCR4 | lapatinib | 0.9673812 | 0.9895734 | 0.967 | NA | NA |
| PTPN11 | lapatinib | 0.9711271 | 0.9895734 | 0.971 | NA | NA |
| FGFR2 | lapatinib | 0.9842030 | 0.9895734 | 0.984 | NA | NA |
| SF3B1 | lapatinib | 0.9865575 | 0.9895734 | 0.987 | NA | NA |
| CSF3R | lapatinib | 0.9895734 | 0.9895734 | 0.990 | NA | NA |
| DNMT3A | erlotinib | 0.9005581 | 0.9898541 | 0.901 | NA | NA |
| GATA3 | erlotinib | 0.9119616 | 0.9898541 | 0.912 | NA | NA |
| ALK | erlotinib | 0.9492432 | 0.9898541 | 0.949 | NA | NA |
| AKT2 | erlotinib | 0.9628110 | 0.9898541 | 0.963 | NA | NA |
| CDK6 | erlotinib | 0.9761607 | 0.9898541 | 0.976 | NA | NA |
| PAX5 | erlotinib | 0.9776368 | 0.9898541 | 0.978 | NA | NA |
| SETD2 | erlotinib | 0.9776368 | 0.9898541 | 0.978 | NA | NA |
| SF3B1 | erlotinib | 0.9789551 | 0.9898541 | 0.979 | NA | NA |
| TP53 | erlotinib | 0.9801201 | 0.9898541 | 0.980 | NA | NA |
| RPL10 | erlotinib | 0.9825514 | 0.9898541 | 0.983 | NA | NA |
| BCOR | erlotinib | 0.9848467 | 0.9898541 | 0.985 | NA | NA |
| PRPF8 | erlotinib | 0.9895951 | 0.9898541 | 0.990 | NA | NA |
| SH2B3 | erlotinib | 0.9898541 | 0.9898541 | 0.990 | NA | NA |
| BTK | nilotinib | 0.7312736 | 0.9919192 | 0.731 | NA | NA |
| TET2 | nilotinib | 0.7479864 | 0.9919192 | 0.748 | NA | NA |
| FGFR3 | nilotinib | 0.7486898 | 0.9919192 | 0.749 | NA | NA |
| FLCN | nilotinib | 0.7541296 | 0.9919192 | 0.754 | NA | NA |
| SETD2 | nilotinib | 0.7552064 | 0.9919192 | 0.755 | NA | NA |
| CREBBP | nilotinib | 0.7621143 | 0.9919192 | 0.762 | NA | NA |
| CTLA4 | nilotinib | 0.7791419 | 0.9919192 | 0.779 | NA | NA |
| BCOR | nilotinib | 0.7961781 | 0.9919192 | 0.796 | NA | NA |
| GATA3 | nilotinib | 0.7977219 | 0.9919192 | 0.798 | NA | NA |
| SMC1A | nilotinib | 0.7980647 | 0.9919192 | 0.798 | NA | NA |
| ALK | nilotinib | 0.7983903 | 0.9919192 | 0.798 | NA | NA |
| TSC1 | nilotinib | 0.7988924 | 0.9919192 | 0.799 | NA | NA |
| GATA2 | nilotinib | 0.8059928 | 0.9919192 | 0.806 | NA | NA |
| RUNX1 | nilotinib | 0.8073074 | 0.9919192 | 0.807 | NA | NA |
| AR | nilotinib | 0.8128485 | 0.9919192 | 0.813 | NA | NA |
| MGMT | nilotinib | 0.8301945 | 0.9919192 | 0.830 | NA | NA |
| MYCN | nilotinib | 0.8448350 | 0.9919192 | 0.845 | NA | NA |
| IL7R | nilotinib | 0.8524502 | 0.9919192 | 0.852 | NA | NA |
| PDGFRA | nilotinib | 0.8621321 | 0.9919192 | 0.862 | NA | NA |
| CXCR4 | nilotinib | 0.8733725 | 0.9919192 | 0.873 | NA | NA |
| EZH2 | nilotinib | 0.8752021 | 0.9919192 | 0.875 | NA | NA |
| STAG2 | nilotinib | 0.8759840 | 0.9919192 | 0.876 | NA | NA |
| MDM2 | nilotinib | 0.8889052 | 0.9919192 | 0.889 | NA | NA |
| RIT1 | nilotinib | 0.8908541 | 0.9919192 | 0.891 | NA | NA |
| NOTCH1 | nilotinib | 0.8983617 | 0.9919192 | 0.898 | NA | NA |
| KMT2A | nilotinib | 0.9084944 | 0.9919192 | 0.908 | NA | NA |
| PML | nilotinib | 0.9170484 | 0.9919192 | 0.917 | NA | NA |
| U2AF1 | nilotinib | 0.9215704 | 0.9919192 | 0.922 | NA | NA |
| HRAS | nilotinib | 0.9225162 | 0.9919192 | 0.923 | NA | NA |
| AKT2 | nilotinib | 0.9311619 | 0.9919192 | 0.931 | NA | NA |
| FGFR2 | nilotinib | 0.9470949 | 0.9919192 | 0.947 | NA | NA |
| BRCA1 | nilotinib | 0.9506540 | 0.9919192 | 0.951 | NA | NA |
| PTCH1 | nilotinib | 0.9525059 | 0.9919192 | 0.953 | NA | NA |
| EGFR | nilotinib | 0.9540597 | 0.9919192 | 0.954 | NA | NA |
| MYCN | irinotecan | 0.9924251 | 0.9924251 | 0.9924 | NA | NA |
| GNAS | nilotinib | 0.9824645 | 0.9989982 | 0.982 | NA | NA |
| SF3B1 | nilotinib | 0.9834968 | 0.9989982 | 0.983 | NA | NA |
| WT1 | nilotinib | 0.9955641 | 0.9989982 | 0.996 | NA | NA |
| BCORL1 | nilotinib | 0.9957000 | 0.9989982 | 0.996 | NA | NA |
| ABL1 | nilotinib | 0.9989982 | 0.9989982 | 0.999 | NA | NA |
wilcox_ccle_gene_lvlA_plot <- ggplot(data = ccle_signif_lvlA) +
geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_ccle_gene_lvlA_plot
ctrp_data_ptmuts <- filter(ctrp_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
ctrp_data_ptmuts$Keep_PtMut_Tests <- ifelse(ctrp_data_ptmuts$Reference_Allele_Length == 1 | is.na(ctrp_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(ctrp_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
ctrp_data_ptmuts <- filter(ctrp_data_ptmuts, Keep_PtMut_Tests == TRUE)
ctrp_data_lvlA <- filter(ctrp_data_ptmuts, Hugo_Symbol %in% genes_lvlA)
ctrp_signif_lvlA_ByDrug <- lapply(unique(ctrp_data_lvlA$Drug), WilcoxonByDrug, dataset = ctrp_data_lvlA, data_name = "CTRP")
names(ctrp_signif_lvlA_ByDrug) <- unique(ctrp_data_lvlA$Drug)
saveRDS(ctrp_signif_lvlA_ByDrug, "./data_munging/rds/ctrp_signif_lvlA_ByDrug.rds")
ctrp_signif_lvlA <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = c("Drug", "Hugo_Symbol"), data = ctrp_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
ctrp_signif_lvlA <- adj_signif(ctrp_signif_lvlA)
ctrp_signif_lvlA <- ctrp_signif_lvlA[order(ctrp_signif_lvlA$p),]
saveRDS(ctrp_signif_lvlA, "./data_munging/rds/ctrp_signif_lvlA_gene.rds")
ctrp_signif_lvlA <- readRDS("./data_munging/rds/ctrp_signif_lvlA_gene.rds")
knitr::kable(ctrp_signif_lvlA[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| BRAF | vemurafenib | 0.0000005 | 0.0008694 | 4.9e-07 | **** | *** |
| PTEN | afatinib | 0.0000005 | 0.0008694 | 5.0e-07 | **** | *** |
| KRAS | lapatinib | 0.0000056 | 0.0065368 | 5.6e-06 | **** | ** |
| KRAS | trametinib | 0.0000123 | 0.0108161 | 1.2e-05 | **** |
|
| KRAS | pazopanib | 0.0000172 | 0.0120592 | 1.7e-05 | **** |
|
| KRAS | ibrutinib | 0.0000293 | 0.0160639 | 2.9e-05 | **** |
|
| MYD88 | vemurafenib | 0.0000321 | 0.0160639 | 3.2e-05 | **** |
|
| PTEN | lapatinib | 0.0000569 | 0.0249108 | 5.7e-05 | **** |
|
| PTEN | sunitinib | 0.0001751 | 0.0596293 | 0.00018 | *** | NA |
| KRAS | selumetinib | 0.0002012 | 0.0596293 | 0.00020 | *** | NA |
| BRAF | selumetinib | 0.0002081 | 0.0596293 | 0.00021 | *** | NA |
| PTEN | neratinib | 0.0002153 | 0.0596293 | 0.00022 | *** | NA |
| TP53 | olaparib | 0.0002233 | 0.0596293 | 0.00022 | *** | NA |
| BRAF | olaparib | 0.0002505 | 0.0596293 | 0.00025 | *** | NA |
| GATA3 | cabozantinib | 0.0002714 | 0.0596293 | 0.00027 | *** | NA |
| BRAF | dabrafenib | 0.0002722 | 0.0596293 | 0.00027 | *** | NA |
| CREBBP | dasatinib | 0.0003347 | 0.0690143 | 0.00033 | *** | NA |
| RUNX1 | regorafenib | 0.0004133 | 0.0765225 | 0.00041 | *** | NA |
| KRAS | sunitinib | 0.0004277 | 0.0765225 | 0.00043 | *** | NA |
| KRAS | neratinib | 0.0004366 | 0.0765225 | 0.00044 | *** | NA |
| EGFR | vemurafenib | 0.0006405 | 0.1034749 | 0.00064 | *** | NA |
| TP53 | crizotinib | 0.0006495 | 0.1034749 | 0.00065 | *** | NA |
| PAX8 | regorafenib | 0.0007275 | 0.1108639 | 0.00073 | *** | NA |
| TP53 | cabozantinib | 0.0007688 | 0.1122800 | 0.00077 | *** | NA |
| BRAF | afatinib | 0.0008985 | 0.1259665 | 0.00090 | *** | NA |
| KRAS | vandetanib | 0.0012628 | 0.1702386 | 0.00126 | ** | NA |
| HRAS | sunitinib | 0.0016468 | 0.2120876 | 0.00165 | ** | NA |
| DNMT3A | vandetanib | 0.0017460 | 0.2120876 | 0.00175 | ** | NA |
| ATM | dasatinib | 0.0017548 | 0.2120876 | 0.00175 | ** | NA |
| PTEN | trametinib | 0.0019075 | 0.2228565 | 0.00191 | ** | NA |
| KRAS | cabozantinib | 0.0020791 | 0.2350669 | 0.00208 | ** | NA |
| BCOR | nilotinib | 0.0022221 | 0.2433909 | 0.00222 | ** | NA |
| SMC1A | vemurafenib | 0.0023813 | 0.2529239 | 0.00238 | ** | NA |
| NRAS | ibrutinib | 0.0025472 | 0.2625880 | 0.00255 | ** | NA |
| PTEN | gefitinib | 0.0027031 | 0.2706975 | 0.00270 | ** | NA |
| DNMT3A | lapatinib | 0.0028992 | 0.2822676 | 0.00290 | ** | NA |
| GATA2 | cabozantinib | 0.0032752 | 0.3102600 | 0.00328 | ** | NA |
| CYP19A1 | vemurafenib | 0.0034645 | 0.3122344 | 0.00346 | ** | NA |
| TP53 | pazopanib | 0.0034742 | 0.3122344 | 0.00347 | ** | NA |
| KRAS | olaparib | 0.0035982 | 0.3152945 | 0.00360 | ** | NA |
| TP53 | regorafenib | 0.0038602 | 0.3207777 | 0.00386 | ** | NA |
| KRAS | gefitinib | 0.0040210 | 0.3207777 | 0.00402 | ** | NA |
| TET2 | cabozantinib | 0.0040527 | 0.3207777 | 0.00405 | ** | NA |
| BRAF | neratinib | 0.0041088 | 0.3207777 | 0.00411 | ** | NA |
| BRAF | pazopanib | 0.0041184 | 0.3207777 | 0.00412 | ** | NA |
| PRPF40B | lapatinib | 0.0047164 | 0.3593692 | 0.00472 | ** | NA |
| BRAF | ibrutinib | 0.0051142 | 0.3813925 | 0.00511 | ** | NA |
| DNMT3A | selumetinib | 0.0054340 | 0.3894881 | 0.00543 | ** | NA |
| PDGFRB | imatinib | 0.0054451 | 0.3894881 | 0.00545 | ** | NA |
| NRAS | lapatinib | 0.0058968 | 0.3993414 | 0.00590 | ** | NA |
| RUNX1 | nilotinib | 0.0060341 | 0.3993414 | 0.00603 | ** | NA |
| NCOA2 | ibrutinib | 0.0061756 | 0.3993414 | 0.00618 | ** | NA |
| PML | fulvestrant | 0.0061906 | 0.3993414 | 0.00619 | ** | NA |
| BRAF | ruxolitinib | 0.0062716 | 0.3993414 | 0.00627 | ** | NA |
| PDGFRB | cabozantinib | 0.0062762 | 0.3993414 | 0.00628 | ** | NA |
| BRAF | trametinib | 0.0064941 | 0.3993414 | 0.00649 | ** | NA |
| XPO1 | nilotinib | 0.0065876 | 0.3993414 | 0.00659 | ** | NA |
| HRAS | pazopanib | 0.0066082 | 0.3993414 | 0.00661 | ** | NA |
| PHF6 | azd | 0.0067277 | 0.3996689 | 0.00673 | ** | NA |
| VHL | belinostat | 0.0076395 | 0.4458479 | 0.00764 | ** | NA |
| NOTCH2 | afatinib | 0.0078494 | 0.4458479 | 0.00785 | ** | NA |
| DNMT3A | gefitinib | 0.0080435 | 0.4458479 | 0.00804 | ** | NA |
| SMC3 | selumetinib | 0.0080758 | 0.4458479 | 0.00808 | ** | NA |
| XPO1 | cabozantinib | 0.0081410 | 0.4458479 | 0.00814 | ** | NA |
| NOTCH1 | cabozantinib | 0.0084048 | 0.4532139 | 0.00840 | ** | NA |
| ERBB2 | cyclophosphamide | 0.0089622 | 0.4642665 | 0.00896 | ** | NA |
| CTCF | cabozantinib | 0.0089651 | 0.4642665 | 0.00897 | ** | NA |
| PIK3CA | cabozantinib | 0.0090072 | 0.4642665 | 0.00901 | ** | NA |
| FANCL | cabozantinib | 0.0094404 | 0.4795429 | 0.00944 | ** | NA |
| VHL | regorafenib | 0.0096726 | 0.4840337 | 0.00967 | ** | NA |
| KRAS | regorafenib | 0.0098050 | 0.4840337 | 0.00980 | ** | NA |
| ERBB2 | cabozantinib | 0.0100336 | 0.4884423 | 0.01003 |
|
NA |
| KRAS | afatinib | 0.0107829 | 0.5155815 | 0.01078 |
|
NA |
| ERBB4 | vemurafenib | 0.0111572 | 0.5155815 | 0.01116 |
|
NA |
| PML | crizotinib | 0.0111785 | 0.5155815 | 0.01118 |
|
NA |
| PIK3CA | dasatinib | 0.0112867 | 0.5155815 | 0.01129 |
|
NA |
| CEBPA | cabozantinib | 0.0113266 | 0.5155815 | 0.01133 |
|
NA |
| RIT1 | dasatinib | 0.0115989 | 0.5182474 | 0.01160 |
|
NA |
| KRAS | vemurafenib | 0.0119766 | 0.5182474 | 0.01198 |
|
NA |
| SMO | crizotinib | 0.0120777 | 0.5182474 | 0.01208 |
|
NA |
| PTEN | fluorouracil | 0.0121037 | 0.5182474 | 0.01210 |
|
NA |
| PAX8 | cabozantinib | 0.0122390 | 0.5182474 | 0.01224 |
|
NA |
| MYD88 | vandetanib | 0.0123446 | 0.5182474 | 0.01234 |
|
NA |
| KRAS | azd | 0.0127676 | 0.5182474 | 0.01277 |
|
NA |
| CREBBP | vandetanib | 0.0128028 | 0.5182474 | 0.01280 |
|
NA |
| ERBB3 | cabozantinib | 0.0128369 | 0.5182474 | 0.01284 |
|
NA |
| RAD21 | vemurafenib | 0.0129631 | 0.5182474 | 0.01296 |
|
NA |
| EML4 | fulvestrant | 0.0130188 | 0.5182474 | 0.01302 |
|
NA |
| FLCN | cabozantinib | 0.0131617 | 0.5182474 | 0.01316 |
|
NA |
| PTEN | nilotinib | 0.0133073 | 0.5182474 | 0.01331 |
|
NA |
| BRAF | temozolomide | 0.0137195 | 0.5284257 | 0.01372 |
|
NA |
| KIT | ibrutinib | 0.0142737 | 0.5316037 | 0.01427 |
|
NA |
| ATM | temozolomide | 0.0145671 | 0.5316037 | 0.01457 |
|
NA |
| NOTCH2 | ibrutinib | 0.0147581 | 0.5316037 | 0.01476 |
|
NA |
| TPMT | sunitinib | 0.0149004 | 0.5316037 | 0.01490 |
|
NA |
| HRAS | belinostat | 0.0149411 | 0.5316037 | 0.01494 |
|
NA |
| DNMT3A | afatinib | 0.0149999 | 0.5316037 | 0.01500 |
|
NA |
| BCORL1 | imatinib | 0.0150008 | 0.5316037 | 0.01500 |
|
NA |
| CEBPA | sunitinib | 0.0150153 | 0.5316037 | 0.01502 |
|
NA |
| PIGA | imatinib | 0.0153322 | 0.5337355 | 0.01533 |
|
NA |
| PML | fluorouracil | 0.0155734 | 0.5337355 | 0.01557 |
|
NA |
| RET | azd | 0.0156276 | 0.5337355 | 0.01563 |
|
NA |
| CDC73 | nilotinib | 0.0157781 | 0.5337355 | 0.01578 |
|
NA |
| PTCH1 | trametinib | 0.0159153 | 0.5337355 | 0.01592 |
|
NA |
| EGF | imatinib | 0.0160677 | 0.5337355 | 0.01607 |
|
NA |
| ROS1 | pazopanib | 0.0165094 | 0.5337355 | 0.01651 |
|
NA |
| PDGFB | regorafenib | 0.0165670 | 0.5337355 | 0.01657 |
|
NA |
| CYP19A1 | regorafenib | 0.0166069 | 0.5337355 | 0.01661 |
|
NA |
| GNAS | cabozantinib | 0.0166176 | 0.5337355 | 0.01662 |
|
NA |
| VHL | cabozantinib | 0.0168908 | 0.5337355 | 0.01689 |
|
NA |
| DNAJB1 | dasatinib | 0.0172411 | 0.5337355 | 0.01724 |
|
NA |
| HRAS | ibrutinib | 0.0172441 | 0.5337355 | 0.01724 |
|
NA |
| GATA2 | olaparib | 0.0172643 | 0.5337355 | 0.01726 |
|
NA |
| TP53 | azd | 0.0173597 | 0.5337355 | 0.01736 |
|
NA |
| UGT1A1 | azd | 0.0180042 | 0.5387827 | 0.01800 |
|
NA |
| STAG2 | neratinib | 0.0181489 | 0.5387827 | 0.01815 |
|
NA |
| DNAJB1 | neratinib | 0.0182441 | 0.5387827 | 0.01824 |
|
NA |
| JAK1 | dasatinib | 0.0182579 | 0.5387827 | 0.01826 |
|
NA |
| HRAS | ruxolitinib | 0.0183784 | 0.5387827 | 0.01838 |
|
NA |
| CDK6 | selumetinib | 0.0186672 | 0.5387827 | 0.01867 |
|
NA |
| BCORL1 | vemurafenib | 0.0187277 | 0.5387827 | 0.01873 |
|
NA |
| SMO | selumetinib | 0.0187536 | 0.5387827 | 0.01875 |
|
NA |
| MDM2 | cabozantinib | 0.0190791 | 0.5426815 | 0.01908 |
|
NA |
| HRAS | crizotinib | 0.0192255 | 0.5426815 | 0.01923 |
|
NA |
| JAK3 | ibrutinib | 0.0193538 | 0.5426815 | 0.01935 |
|
NA |
| MPL | crizotinib | 0.0200362 | 0.5517127 | 0.02004 |
|
NA |
| PTEN | vandetanib | 0.0203414 | 0.5517127 | 0.02034 |
|
NA |
| NRAS | selumetinib | 0.0204159 | 0.5517127 | 0.02042 |
|
NA |
| PTEN | pazopanib | 0.0204199 | 0.5517127 | 0.02042 |
|
NA |
| PDCD1 | dasatinib | 0.0204630 | 0.5517127 | 0.02046 |
|
NA |
| JAK3 | gefitinib | 0.0210547 | 0.5633346 | 0.02105 |
|
NA |
| SF3B1 | temozolomide | 0.0216735 | 0.5646563 | 0.02167 |
|
NA |
| BCOR | regorafenib | 0.0216994 | 0.5646563 | 0.02170 |
|
NA |
| CTLA4 | erlotinib | 0.0217734 | 0.5646563 | 0.02177 |
|
NA |
| SMO | azd | 0.0219539 | 0.5646563 | 0.02195 |
|
NA |
| BRAF | cyclophosphamide | 0.0222337 | 0.5646563 | 0.02223 |
|
NA |
| NRAS | vandetanib | 0.0222810 | 0.5646563 | 0.02228 |
|
NA |
| HRAS | cabozantinib | 0.0226792 | 0.5646563 | 0.02268 |
|
NA |
| SMO | dasatinib | 0.0227029 | 0.5646563 | 0.02270 |
|
NA |
| FBXW7 | selumetinib | 0.0228040 | 0.5646563 | 0.02280 |
|
NA |
| PRPF40B | afatinib | 0.0230376 | 0.5646563 | 0.02304 |
|
NA |
| ALK | neratinib | 0.0230681 | 0.5646563 | 0.02307 |
|
NA |
| PTEN | crizotinib | 0.0231108 | 0.5646563 | 0.02311 |
|
NA |
| DNMT3A | trametinib | 0.0232930 | 0.5646563 | 0.02329 |
|
NA |
| NRAS | erlotinib | 0.0233595 | 0.5646563 | 0.02336 |
|
NA |
| PHF6 | dasatinib | 0.0240009 | 0.5705146 | 0.02400 |
|
NA |
| CTLA4 | gefitinib | 0.0240362 | 0.5705146 | 0.02404 |
|
NA |
| MPL | pazopanib | 0.0241053 | 0.5705146 | 0.02411 |
|
NA |
| FGFR1 | dabrafenib | 0.0242530 | 0.5705146 | 0.02425 |
|
NA |
| ESR1 | imatinib | 0.0245120 | 0.5727630 | 0.02451 |
|
NA |
| CTLA4 | lapatinib | 0.0249688 | 0.5795745 | 0.02497 |
|
NA |
| VHL | pazopanib | 0.0252851 | 0.5830554 | 0.02529 |
|
NA |
| CDC73 | regorafenib | 0.0254828 | 0.5837727 | 0.02548 |
|
NA |
| ZRSR2 | cabozantinib | 0.0257289 | 0.5855820 | 0.02573 |
|
NA |
| RUNX1 | cabozantinib | 0.0262773 | 0.5934298 | 0.02628 |
|
NA |
| PAX8 | nilotinib | 0.0264123 | 0.5934298 | 0.02641 |
|
NA |
| BRCA1 | fulvestrant | 0.0266668 | 0.5953326 | 0.02667 |
|
NA |
| JAK2 | temozolomide | 0.0271063 | 0.5981327 | 0.02711 |
|
NA |
| JAK3 | neratinib | 0.0274252 | 0.5981327 | 0.02743 |
|
NA |
| CDC73 | vemurafenib | 0.0274453 | 0.5981327 | 0.02745 |
|
NA |
| SF3B1 | pazopanib | 0.0274831 | 0.5981327 | 0.02748 |
|
NA |
| DNMT3A | crizotinib | 0.0276455 | 0.5981327 | 0.02765 |
|
NA |
| TET2 | gefitinib | 0.0285365 | 0.6136220 | 0.02854 |
|
NA |
| FBXW7 | erlotinib | 0.0290920 | 0.6188596 | 0.02909 |
|
NA |
| RPL10 | vemurafenib | 0.0291978 | 0.6188596 | 0.02920 |
|
NA |
| PIK3CA | dabrafenib | 0.0293098 | 0.6188596 | 0.02931 |
|
NA |
| BRAF | dasatinib | 0.0300319 | 0.6288704 | 0.03003 |
|
NA |
| PHF6 | cabozantinib | 0.0304007 | 0.6288704 | 0.03040 |
|
NA |
| EML4 | temozolomide | 0.0304800 | 0.6288704 | 0.03048 |
|
NA |
| BRAF | lapatinib | 0.0305016 | 0.6288704 | 0.03050 |
|
NA |
| MAP2K1 | dabrafenib | 0.0309555 | 0.6320875 | 0.03096 |
|
NA |
| EGF | erlotinib | 0.0314188 | 0.6320875 | 0.03142 |
|
NA |
| PML | selumetinib | 0.0317252 | 0.6320875 | 0.03173 |
|
NA |
| CRLF2 | neratinib | 0.0323240 | 0.6320875 | 0.03232 |
|
NA |
| GNA11 | ruxolitinib | 0.0327779 | 0.6320875 | 0.03278 |
|
NA |
| PDGFRA | ibrutinib | 0.0333483 | 0.6320875 | 0.03335 |
|
NA |
| CTLA4 | neratinib | 0.0336983 | 0.6320875 | 0.03370 |
|
NA |
| CDKN2A | olaparib | 0.0337054 | 0.6320875 | 0.03371 |
|
NA |
| DNMT3A | ibrutinib | 0.0340522 | 0.6320875 | 0.03405 |
|
NA |
| UGT1A1 | pazopanib | 0.0341719 | 0.6320875 | 0.03417 |
|
NA |
| TSC2 | vemurafenib | 0.0345796 | 0.6320875 | 0.03458 |
|
NA |
| CDKN2A | pazopanib | 0.0349638 | 0.6320875 | 0.03496 |
|
NA |
| PRPF40B | fulvestrant | 0.0350898 | 0.6320875 | 0.03509 |
|
NA |
| DPYD | selumetinib | 0.0356352 | 0.6320875 | 0.03564 |
|
NA |
| DNMT3A | neratinib | 0.0356380 | 0.6320875 | 0.03564 |
|
NA |
| PIGA | fulvestrant | 0.0357583 | 0.6320875 | 0.03576 |
|
NA |
| SMC3 | gefitinib | 0.0358853 | 0.6320875 | 0.03589 |
|
NA |
| PHF6 | vandetanib | 0.0358904 | 0.6320875 | 0.03589 |
|
NA |
| AR | belinostat | 0.0359620 | 0.6320875 | 0.03596 |
|
NA |
| MET | vemurafenib | 0.0360691 | 0.6320875 | 0.03607 |
|
NA |
| KIT | cabozantinib | 0.0362427 | 0.6320875 | 0.03624 |
|
NA |
| PTEN | temozolomide | 0.0366028 | 0.6320875 | 0.03660 |
|
NA |
| PDGFRB | afatinib | 0.0366997 | 0.6320875 | 0.03670 |
|
NA |
| PIK3CA | erlotinib | 0.0371212 | 0.6320875 | 0.03712 |
|
NA |
| BCOR | ruxolitinib | 0.0371517 | 0.6320875 | 0.03715 |
|
NA |
| FBXW7 | neratinib | 0.0372624 | 0.6320875 | 0.03726 |
|
NA |
| NT5C2 | nilotinib | 0.0376566 | 0.6320875 | 0.03766 |
|
NA |
| TET2 | regorafenib | 0.0379740 | 0.6320875 | 0.03797 |
|
NA |
| ROS1 | gefitinib | 0.0380067 | 0.6320875 | 0.03801 |
|
NA |
| TPMT | selumetinib | 0.0382776 | 0.6320875 | 0.03828 |
|
NA |
| TSC2 | cabozantinib | 0.0383320 | 0.6320875 | 0.03833 |
|
NA |
| VHL | azd | 0.0384356 | 0.6320875 | 0.03844 |
|
NA |
| PTPN11 | selumetinib | 0.0388001 | 0.6320875 | 0.03880 |
|
NA |
| PIGA | pazopanib | 0.0390453 | 0.6320875 | 0.03905 |
|
NA |
| ROS1 | cabozantinib | 0.0390533 | 0.6320875 | 0.03905 |
|
NA |
| MYCN | azd | 0.0391289 | 0.6320875 | 0.03913 |
|
NA |
| MYCN | neratinib | 0.0391545 | 0.6320875 | 0.03915 |
|
NA |
| CBL | dabrafenib | 0.0392087 | 0.6320875 | 0.03921 |
|
NA |
| EGF | dasatinib | 0.0392917 | 0.6320875 | 0.03929 |
|
NA |
| BRAF | fluorouracil | 0.0393299 | 0.6320875 | 0.03933 |
|
NA |
| ASXL1 | temozolomide | 0.0395183 | 0.6320875 | 0.03952 |
|
NA |
| PHF6 | ibrutinib | 0.0395194 | 0.6320875 | 0.03952 |
|
NA |
| PRPF40B | olaparib | 0.0395265 | 0.6320875 | 0.03953 |
|
NA |
| CXCR4 | pazopanib | 0.0395940 | 0.6320875 | 0.03959 |
|
NA |
| KIT | afatinib | 0.0398249 | 0.6320875 | 0.03982 |
|
NA |
| NRAS | belinostat | 0.0399072 | 0.6320875 | 0.03991 |
|
NA |
| PRPF8 | nilotinib | 0.0400544 | 0.6320875 | 0.04005 |
|
NA |
| BCOR | dabrafenib | 0.0401328 | 0.6320875 | 0.04013 |
|
NA |
| HRAS | lapatinib | 0.0405701 | 0.6320875 | 0.04057 |
|
NA |
| CTCF | vemurafenib | 0.0408744 | 0.6320875 | 0.04087 |
|
NA |
| FLT3 | cabozantinib | 0.0412322 | 0.6320875 | 0.04123 |
|
NA |
| MET | sunitinib | 0.0414057 | 0.6320875 | 0.04141 |
|
NA |
| TP53 | sunitinib | 0.0414916 | 0.6320875 | 0.04149 |
|
NA |
| CBL | pazopanib | 0.0415646 | 0.6320875 | 0.04156 |
|
NA |
| BRAF | azd | 0.0415725 | 0.6320875 | 0.04157 |
|
NA |
| VHL | olaparib | 0.0419848 | 0.6320875 | 0.04198 |
|
NA |
| PTEN | imatinib | 0.0421067 | 0.6320875 | 0.04211 |
|
NA |
| VHL | crizotinib | 0.0421297 | 0.6320875 | 0.04213 |
|
NA |
| EZH2 | dabrafenib | 0.0423964 | 0.6320875 | 0.04240 |
|
NA |
| TP53 | temozolomide | 0.0424331 | 0.6320875 | 0.04243 |
|
NA |
| IL7R | neratinib | 0.0424641 | 0.6320875 | 0.04246 |
|
NA |
| DNMT3A | erlotinib | 0.0426319 | 0.6320875 | 0.04263 |
|
NA |
| WHSC1 | trametinib | 0.0427866 | 0.6320875 | 0.04279 |
|
NA |
| SMO | vemurafenib | 0.0429379 | 0.6320875 | 0.04294 |
|
NA |
| CYP19A1 | imatinib | 0.0430959 | 0.6320875 | 0.04310 |
|
NA |
| PTEN | erlotinib | 0.0432137 | 0.6320875 | 0.04321 |
|
NA |
| CBL | cabozantinib | 0.0433410 | 0.6320875 | 0.04334 |
|
NA |
| FLT3 | olaparib | 0.0434999 | 0.6320875 | 0.04350 |
|
NA |
| IKZF1 | dasatinib | 0.0435525 | 0.6320875 | 0.04355 |
|
NA |
| MET | crizotinib | 0.0436200 | 0.6320875 | 0.04362 |
|
NA |
| WT1 | neratinib | 0.0437295 | 0.6320875 | 0.04373 |
|
NA |
| PTEN | regorafenib | 0.0437414 | 0.6320875 | 0.04374 |
|
NA |
| FLCN | vemurafenib | 0.0441692 | 0.6320875 | 0.04417 |
|
NA |
| PIGA | crizotinib | 0.0446094 | 0.6320875 | 0.04461 |
|
NA |
| CRLF2 | fluorouracil | 0.0446618 | 0.6320875 | 0.04466 |
|
NA |
| AKT2 | imatinib | 0.0447614 | 0.6320875 | 0.04476 |
|
NA |
| ROS1 | azd | 0.0447795 | 0.6320875 | 0.04478 |
|
NA |
| CTCF | nilotinib | 0.0447893 | 0.6320875 | 0.04479 |
|
NA |
| PTEN | selumetinib | 0.0449044 | 0.6320875 | 0.04490 |
|
NA |
| SMC3 | erlotinib | 0.0455886 | 0.6341430 | 0.04559 |
|
NA |
| CEBPA | imatinib | 0.0455890 | 0.6341430 | 0.04559 |
|
NA |
| CTCF | dasatinib | 0.0456479 | 0.6341430 | 0.04565 |
|
NA |
| ROS1 | olaparib | 0.0457741 | 0.6341430 | 0.04577 |
|
NA |
| WHSC1 | selumetinib | 0.0468008 | 0.6401197 | 0.04680 |
|
NA |
| GNA11 | trametinib | 0.0468157 | 0.6401197 | 0.04682 |
|
NA |
| AKT2 | vemurafenib | 0.0468663 | 0.6401197 | 0.04687 |
|
NA |
| CRLF2 | afatinib | 0.0469360 | 0.6401197 | 0.04694 |
|
NA |
| MAP2K2 | dabrafenib | 0.0485597 | 0.6506653 | 0.04856 |
|
NA |
| TSC1 | nilotinib | 0.0489600 | 0.6506653 | 0.04896 |
|
NA |
| RPL10 | imatinib | 0.0490026 | 0.6506653 | 0.04900 |
|
NA |
| NT5C2 | lapatinib | 0.0490205 | 0.6506653 | 0.04902 |
|
NA |
| MDM2 | temozolomide | 0.0490362 | 0.6506653 | 0.04904 |
|
NA |
| FANCL | regorafenib | 0.0492450 | 0.6506653 | 0.04924 |
|
NA |
| KMT2A | vemurafenib | 0.0492856 | 0.6506653 | 0.04929 |
|
NA |
| BRCA1 | belinostat | 0.0497327 | 0.6506653 | 0.04973 |
|
NA |
| PIGA | azd | 0.0499171 | 0.6506653 | 0.04992 |
|
NA |
| XPO1 | regorafenib | 0.0499890 | 0.6506653 | 0.04999 |
|
NA |
| PDGFRB | regorafenib | 0.0500392 | 0.6506653 | 0.05004 | NA | NA |
| ALK | dasatinib | 0.0501428 | 0.6506653 | 0.05014 | NA | NA |
| PIK3CA | sunitinib | 0.0503301 | 0.6506653 | 0.05033 | NA | NA |
| MET | selumetinib | 0.0507587 | 0.6506653 | 0.05076 | NA | NA |
| KRAS | crizotinib | 0.0508005 | 0.6506653 | 0.05080 | NA | NA |
| NOTCH2 | fulvestrant | 0.0519985 | 0.6506653 | 0.05200 | NA | NA |
| PAX5 | cabozantinib | 0.0520777 | 0.6506653 | 0.05208 | NA | NA |
| PHF6 | nilotinib | 0.0521758 | 0.6506653 | 0.05218 | NA | NA |
| PTCH1 | regorafenib | 0.0522146 | 0.6506653 | 0.05221 | NA | NA |
| VHL | sunitinib | 0.0523565 | 0.6506653 | 0.05236 | NA | NA |
| MAP2K2 | afatinib | 0.0523654 | 0.6506653 | 0.05237 | NA | NA |
| GNAQ | gefitinib | 0.0524208 | 0.6506653 | 0.05242 | NA | NA |
| PTCH1 | vemurafenib | 0.0527029 | 0.6506653 | 0.05270 | NA | NA |
| CDC73 | cabozantinib | 0.0528058 | 0.6506653 | 0.05281 | NA | NA |
| RET | selumetinib | 0.0529915 | 0.6506653 | 0.05299 | NA | NA |
| BRCA1 | vemurafenib | 0.0531252 | 0.6506653 | 0.05313 | NA | NA |
| ALK | vandetanib | 0.0531880 | 0.6506653 | 0.05319 | NA | NA |
| XPO1 | vemurafenib | 0.0534441 | 0.6506653 | 0.05344 | NA | NA |
| RUNX1 | vemurafenib | 0.0536122 | 0.6506653 | 0.05361 | NA | NA |
| PDGFRA | gefitinib | 0.0538638 | 0.6506653 | 0.05386 | NA | NA |
| CTLA4 | vandetanib | 0.0539976 | 0.6506653 | 0.05400 | NA | NA |
| NCOA2 | lapatinib | 0.0541227 | 0.6506653 | 0.05412 | NA | NA |
| WHSC1 | ruxolitinib | 0.0541464 | 0.6506653 | 0.05415 | NA | NA |
| RUNX1 | ibrutinib | 0.0541729 | 0.6506653 | 0.05417 | NA | NA |
| FGFR3 | trametinib | 0.0542066 | 0.6506653 | 0.05421 | NA | NA |
| DNAJB1 | olaparib | 0.0546041 | 0.6520244 | 0.05460 | NA | NA |
| GNAQ | imatinib | 0.0546919 | 0.6520244 | 0.05469 | NA | NA |
| MET | nilotinib | 0.0553000 | 0.6554101 | 0.05530 | NA | NA |
| CD79B | ibrutinib | 0.0553499 | 0.6554101 | 0.05535 | NA | NA |
| JAK2 | nilotinib | 0.0558396 | 0.6589824 | 0.05584 | NA | NA |
| SMO | vandetanib | 0.0561251 | 0.6599344 | 0.05613 | NA | NA |
| TPMT | imatinib | 0.0564058 | 0.6599344 | 0.05641 | NA | NA |
| NT5C2 | neratinib | 0.0564851 | 0.6599344 | 0.05649 | NA | NA |
| BRCA2 | temozolomide | 0.0567584 | 0.6605021 | 0.05676 | NA | NA |
| U2AF1 | lapatinib | 0.0573937 | 0.6605021 | 0.05739 | NA | NA |
| MYD88 | temozolomide | 0.0574402 | 0.6605021 | 0.05744 | NA | NA |
| NPM1 | lapatinib | 0.0576027 | 0.6605021 | 0.05760 | NA | NA |
| RIT1 | neratinib | 0.0576777 | 0.6605021 | 0.05768 | NA | NA |
| NCOA2 | neratinib | 0.0577406 | 0.6605021 | 0.05774 | NA | NA |
| MGMT | dabrafenib | 0.0578528 | 0.6605021 | 0.05785 | NA | NA |
| IDH2 | olaparib | 0.0581368 | 0.6615887 | 0.05814 | NA | NA |
| NCOA2 | vemurafenib | 0.0586660 | 0.6632341 | 0.05867 | NA | NA |
| PTCH1 | temozolomide | 0.0588364 | 0.6632341 | 0.05884 | NA | NA |
| HRAS | vandetanib | 0.0589220 | 0.6632341 | 0.05892 | NA | NA |
| ALK | crizotinib | 0.0595488 | 0.6632341 | 0.05955 | NA | NA |
| CBLB | dabrafenib | 0.0596936 | 0.6632341 | 0.05969 | NA | NA |
| GATA3 | fluorouracil | 0.0598679 | 0.6632341 | 0.05987 | NA | NA |
| JAK3 | dabrafenib | 0.0601470 | 0.6632341 | 0.06015 | NA | NA |
| JAK2 | cabozantinib | 0.0601835 | 0.6632341 | 0.06018 | NA | NA |
| CD274 | nilotinib | 0.0604135 | 0.6632341 | 0.06041 | NA | NA |
| EZH2 | belinostat | 0.0605653 | 0.6632341 | 0.06057 | NA | NA |
| PIK3CA | fluorouracil | 0.0606871 | 0.6632341 | 0.06069 | NA | NA |
| ABL1 | cyclophosphamide | 0.0608027 | 0.6632341 | 0.06080 | NA | NA |
| PDGFRB | sunitinib | 0.0609026 | 0.6632341 | 0.06090 | NA | NA |
| GATA3 | temozolomide | 0.0609305 | 0.6632341 | 0.06093 | NA | NA |
| VHL | fluorouracil | 0.0611560 | 0.6636274 | 0.06116 | NA | NA |
| DNAJB1 | trametinib | 0.0614179 | 0.6636970 | 0.06142 | NA | NA |
| PTCH1 | imatinib | 0.0615411 | 0.6636970 | 0.06154 | NA | NA |
| DPYD | neratinib | 0.0622681 | 0.6672391 | 0.06227 | NA | NA |
| PDGFRA | lapatinib | 0.0624698 | 0.6672391 | 0.06247 | NA | NA |
| PTCH1 | erlotinib | 0.0624883 | 0.6672391 | 0.06249 | NA | NA |
| EGF | gefitinib | 0.0626864 | 0.6672391 | 0.06269 | NA | NA |
| MET | cabozantinib | 0.0628214 | 0.6672391 | 0.06282 | NA | NA |
| EGF | afatinib | 0.0638562 | 0.6725304 | 0.06386 | NA | NA |
| CYP19A1 | dasatinib | 0.0644360 | 0.6725304 | 0.06444 | NA | NA |
| FGFR1 | cyclophosphamide | 0.0645668 | 0.6725304 | 0.06457 | NA | NA |
| AKT3 | dasatinib | 0.0647027 | 0.6725304 | 0.06470 | NA | NA |
| AR | cabozantinib | 0.0650406 | 0.6725304 | 0.06504 | NA | NA |
| SMC1A | cyclophosphamide | 0.0651050 | 0.6725304 | 0.06511 | NA | NA |
| EZH2 | crizotinib | 0.0651601 | 0.6725304 | 0.06516 | NA | NA |
| PTCH1 | sunitinib | 0.0653514 | 0.6725304 | 0.06535 | NA | NA |
| TP53 | fluorouracil | 0.0659191 | 0.6725304 | 0.06592 | NA | NA |
| UGT1A1 | cabozantinib | 0.0659861 | 0.6725304 | 0.06599 | NA | NA |
| STAT3 | dasatinib | 0.0662264 | 0.6725304 | 0.06623 | NA | NA |
| SRSF2 | neratinib | 0.0664900 | 0.6725304 | 0.06649 | NA | NA |
| ERBB2 | fulvestrant | 0.0667862 | 0.6725304 | 0.06679 | NA | NA |
| SSX1 | temozolomide | 0.0670487 | 0.6725304 | 0.06705 | NA | NA |
| AKT1 | cabozantinib | 0.0671417 | 0.6725304 | 0.06714 | NA | NA |
| DNMT3A | sunitinib | 0.0672906 | 0.6725304 | 0.06729 | NA | NA |
| EGFR | regorafenib | 0.0674563 | 0.6725304 | 0.06746 | NA | NA |
| MPL | gefitinib | 0.0678851 | 0.6725304 | 0.06789 | NA | NA |
| CALR | dabrafenib | 0.0679741 | 0.6725304 | 0.06797 | NA | NA |
| CTLA4 | temozolomide | 0.0680635 | 0.6725304 | 0.06806 | NA | NA |
| ROS1 | crizotinib | 0.0682314 | 0.6725304 | 0.06823 | NA | NA |
| MET | gefitinib | 0.0682941 | 0.6725304 | 0.06829 | NA | NA |
| NOTCH2 | trametinib | 0.0686269 | 0.6725304 | 0.06863 | NA | NA |
| ROS1 | erlotinib | 0.0687863 | 0.6725304 | 0.06879 | NA | NA |
| FBXW7 | temozolomide | 0.0689091 | 0.6725304 | 0.06891 | NA | NA |
| CTLA4 | regorafenib | 0.0689931 | 0.6725304 | 0.06899 | NA | NA |
| GATA1 | regorafenib | 0.0690666 | 0.6725304 | 0.06907 | NA | NA |
| JAK2 | erlotinib | 0.0694206 | 0.6725304 | 0.06942 | NA | NA |
| JAK2 | gefitinib | 0.0695010 | 0.6725304 | 0.06950 | NA | NA |
| PTEN | ibrutinib | 0.0695343 | 0.6725304 | 0.06953 | NA | NA |
| MAP2K2 | fulvestrant | 0.0695606 | 0.6725304 | 0.06956 | NA | NA |
| KRAS | ruxolitinib | 0.0698118 | 0.6725304 | 0.06981 | NA | NA |
| GATA2 | ruxolitinib | 0.0699082 | 0.6725304 | 0.06991 | NA | NA |
| KRAS | nilotinib | 0.0700538 | 0.6725304 | 0.07005 | NA | NA |
| FGFR1 | vandetanib | 0.0700597 | 0.6725304 | 0.07006 | NA | NA |
| RAD21 | dabrafenib | 0.0703494 | 0.6725304 | 0.07035 | NA | NA |
| U2AF1 | regorafenib | 0.0704190 | 0.6725304 | 0.07042 | NA | NA |
| PAX8 | imatinib | 0.0710267 | 0.6728311 | 0.07103 | NA | NA |
| TPMT | afatinib | 0.0710783 | 0.6728311 | 0.07108 | NA | NA |
| CTNNB1 | regorafenib | 0.0711165 | 0.6728311 | 0.07112 | NA | NA |
| DPYD | azd | 0.0712184 | 0.6728311 | 0.07122 | NA | NA |
| MAP2K1 | regorafenib | 0.0717891 | 0.6764000 | 0.07179 | NA | NA |
| CD274 | sunitinib | 0.0724713 | 0.6766861 | 0.07247 | NA | NA |
| ALK | afatinib | 0.0725102 | 0.6766861 | 0.07251 | NA | NA |
| MAP2K2 | gefitinib | 0.0725157 | 0.6766861 | 0.07252 | NA | NA |
| CEBPA | crizotinib | 0.0725917 | 0.6766861 | 0.07259 | NA | NA |
| EML4 | trametinib | 0.0732986 | 0.6801743 | 0.07330 | NA | NA |
| SMO | nilotinib | 0.0734446 | 0.6801743 | 0.07344 | NA | NA |
| PDGFRA | vemurafenib | 0.0735826 | 0.6801743 | 0.07358 | NA | NA |
| PTEN | cabozantinib | 0.0738681 | 0.6801743 | 0.07387 | NA | NA |
| G6PD | regorafenib | 0.0740828 | 0.6801743 | 0.07408 | NA | NA |
| MPL | imatinib | 0.0742277 | 0.6801743 | 0.07423 | NA | NA |
| KIT | selumetinib | 0.0746874 | 0.6801743 | 0.07469 | NA | NA |
| CTCF | fluorouracil | 0.0748081 | 0.6801743 | 0.07481 | NA | NA |
| CDK6 | imatinib | 0.0748933 | 0.6801743 | 0.07489 | NA | NA |
| NPM1 | pazopanib | 0.0750765 | 0.6801743 | 0.07508 | NA | NA |
| TPMT | cabozantinib | 0.0751475 | 0.6801743 | 0.07515 | NA | NA |
| FLCN | olaparib | 0.0752946 | 0.6801743 | 0.07529 | NA | NA |
| CXCR4 | vemurafenib | 0.0758761 | 0.6829912 | 0.07588 | NA | NA |
| TSC1 | vemurafenib | 0.0759962 | 0.6829912 | 0.07600 | NA | NA |
| PIK3CA | ibrutinib | 0.0765203 | 0.6859432 | 0.07652 | NA | NA |
| SSX1 | gefitinib | 0.0767754 | 0.6861057 | 0.07678 | NA | NA |
| GNAS | lapatinib | 0.0769300 | 0.6861057 | 0.07693 | NA | NA |
| JAK1 | vemurafenib | 0.0784429 | 0.6967987 | 0.07844 | NA | NA |
| MYCN | lapatinib | 0.0785265 | 0.6967987 | 0.07853 | NA | NA |
| PML | vemurafenib | 0.0789218 | 0.6979744 | 0.07892 | NA | NA |
| SRSF2 | olaparib | 0.0791994 | 0.6979744 | 0.07920 | NA | NA |
| KMT2A | cabozantinib | 0.0793512 | 0.6979744 | 0.07935 | NA | NA |
| TSC1 | fluorouracil | 0.0794633 | 0.6979744 | 0.07946 | NA | NA |
| PTPN11 | gefitinib | 0.0796547 | 0.6979744 | 0.07965 | NA | NA |
| UGT1A1 | sunitinib | 0.0800633 | 0.6998049 | 0.08006 | NA | NA |
| DNMT3A | fluorouracil | 0.0810167 | 0.7063768 | 0.08102 | NA | NA |
| G6PD | nilotinib | 0.0817599 | 0.7079988 | 0.08176 | NA | NA |
| FBXW7 | vandetanib | 0.0818241 | 0.7079988 | 0.08182 | NA | NA |
| PDGFRA | erlotinib | 0.0818940 | 0.7079988 | 0.08189 | NA | NA |
| CD79B | cabozantinib | 0.0821957 | 0.7079988 | 0.08220 | NA | NA |
| ERBB2 | dabrafenib | 0.0822127 | 0.7079988 | 0.08221 | NA | NA |
| RET | afatinib | 0.0832455 | 0.7126256 | 0.08325 | NA | NA |
| MDM2 | sunitinib | 0.0835956 | 0.7126256 | 0.08360 | NA | NA |
| CDKN2A | crizotinib | 0.0836611 | 0.7126256 | 0.08366 | NA | NA |
| PDGFRB | trametinib | 0.0837396 | 0.7126256 | 0.08374 | NA | NA |
| BRCA2 | vemurafenib | 0.0837665 | 0.7126256 | 0.08377 | NA | NA |
| MYD88 | nilotinib | 0.0840035 | 0.7129111 | 0.08400 | NA | NA |
| CDKN2A | sunitinib | 0.0845214 | 0.7155738 | 0.08452 | NA | NA |
| PIGA | regorafenib | 0.0851757 | 0.7161199 | 0.08518 | NA | NA |
| STAT3 | erlotinib | 0.0853030 | 0.7161199 | 0.08530 | NA | NA |
| FLCN | fluorouracil | 0.0853732 | 0.7161199 | 0.08537 | NA | NA |
| CREBBP | sunitinib | 0.0855553 | 0.7161199 | 0.08556 | NA | NA |
| HRAS | dasatinib | 0.0856075 | 0.7161199 | 0.08561 | NA | NA |
| SETD2 | fluorouracil | 0.0859390 | 0.7171812 | 0.08594 | NA | NA |
| RPL10 | vandetanib | 0.0862184 | 0.7178040 | 0.08622 | NA | NA |
| JAK1 | cabozantinib | 0.0867994 | 0.7202102 | 0.08680 | NA | NA |
| WHSC1 | imatinib | 0.0870643 | 0.7202102 | 0.08706 | NA | NA |
| BRCA1 | azd | 0.0871239 | 0.7202102 | 0.08712 | NA | NA |
| CDC73 | temozolomide | 0.0876395 | 0.7227684 | 0.08764 | NA | NA |
| GATA2 | imatinib | 0.0881485 | 0.7252593 | 0.08815 | NA | NA |
| ERBB4 | olaparib | 0.0888830 | 0.7277387 | 0.08888 | NA | NA |
| TPMT | crizotinib | 0.0889926 | 0.7277387 | 0.08899 | NA | NA |
| PRPF8 | vemurafenib | 0.0891286 | 0.7277387 | 0.08913 | NA | NA |
| KIT | trametinib | 0.0892804 | 0.7277387 | 0.08928 | NA | NA |
| GATA1 | dabrafenib | 0.0898472 | 0.7304655 | 0.08985 | NA | NA |
| PIGA | cabozantinib | 0.0902445 | 0.7304655 | 0.09024 | NA | NA |
| MPL | sunitinib | 0.0903895 | 0.7304655 | 0.09039 | NA | NA |
| RET | fluorouracil | 0.0904485 | 0.7304655 | 0.09045 | NA | NA |
| PIK3CA | vemurafenib | 0.0908048 | 0.7305190 | 0.09080 | NA | NA |
| CTLA4 | cabozantinib | 0.0908924 | 0.7305190 | 0.09089 | NA | NA |
| EML4 | ibrutinib | 0.0917280 | 0.7305190 | 0.09173 | NA | NA |
| NOTCH2 | vandetanib | 0.0917596 | 0.7305190 | 0.09176 | NA | NA |
| SMO | neratinib | 0.0919955 | 0.7305190 | 0.09200 | NA | NA |
| ERBB4 | temozolomide | 0.0921082 | 0.7305190 | 0.09211 | NA | NA |
| SMC1A | dasatinib | 0.0921852 | 0.7305190 | 0.09219 | NA | NA |
| BCOR | trametinib | 0.0923148 | 0.7305190 | 0.09231 | NA | NA |
| BRCA2 | pazopanib | 0.0923309 | 0.7305190 | 0.09233 | NA | NA |
| TPMT | dasatinib | 0.0925509 | 0.7306098 | 0.09255 | NA | NA |
| ROS1 | nilotinib | 0.0927972 | 0.7309081 | 0.09280 | NA | NA |
| STAG2 | olaparib | 0.0932183 | 0.7323869 | 0.09322 | NA | NA |
| PDGFRA | temozolomide | 0.0937160 | 0.7323869 | 0.09372 | NA | NA |
| SRSF2 | afatinib | 0.0937442 | 0.7323869 | 0.09374 | NA | NA |
| TET2 | nilotinib | 0.0938208 | 0.7323869 | 0.09382 | NA | NA |
| FBXW7 | olaparib | 0.0940419 | 0.7324818 | 0.09404 | NA | NA |
| G6PD | dabrafenib | 0.0952173 | 0.7399928 | 0.09522 | NA | NA |
| NRAS | trametinib | 0.0961814 | 0.7418025 | 0.09618 | NA | NA |
| EGF | regorafenib | 0.0962004 | 0.7418025 | 0.09620 | NA | NA |
| ERBB4 | crizotinib | 0.0965888 | 0.7418025 | 0.09659 | NA | NA |
| CDKN2A | ruxolitinib | 0.0966854 | 0.7418025 | 0.09669 | NA | NA |
| RET | cyclophosphamide | 0.0968718 | 0.7418025 | 0.09687 | NA | NA |
| CD274 | ruxolitinib | 0.0972548 | 0.7418025 | 0.09725 | NA | NA |
| CTCF | erlotinib | 0.0973786 | 0.7418025 | 0.09738 | NA | NA |
| MAP2K2 | vandetanib | 0.0974409 | 0.7418025 | 0.09744 | NA | NA |
| STAG2 | regorafenib | 0.0976712 | 0.7418025 | 0.09767 | NA | NA |
| FGFR3 | imatinib | 0.0977628 | 0.7418025 | 0.09776 | NA | NA |
| PDCD1 | vemurafenib | 0.0977783 | 0.7418025 | 0.09778 | NA | NA |
| GATA3 | sunitinib | 0.0981168 | 0.7427632 | 0.09812 | NA | NA |
| DNAJB1 | afatinib | 0.0985287 | 0.7442737 | 0.09853 | NA | NA |
| PTEN | dabrafenib | 0.0990454 | 0.7465681 | 0.09905 | NA | NA |
| DNMT3A | olaparib | 0.0996068 | 0.7480260 | 0.09961 | NA | NA |
| RPL10 | temozolomide | 0.0996657 | 0.7480260 | 0.09967 | NA | NA |
| CDK4 | dabrafenib | 0.1007756 | 0.7541059 | 0.10078 | NA | NA |
| PIK3CA | crizotinib | 0.1009281 | 0.7541059 | 0.10093 | NA | NA |
| BCOR | temozolomide | 0.1011212 | 0.7541059 | 0.10112 | NA | NA |
| XPO1 | temozolomide | 0.1017504 | 0.7571871 | 0.10175 | NA | NA |
| SF1 | cabozantinib | 0.1022414 | 0.7581569 | 0.10224 | NA | NA |
| PIGA | sunitinib | 0.1023133 | 0.7581569 | 0.10231 | NA | NA |
| NOTCH2 | temozolomide | 0.1032821 | 0.7599893 | 0.10328 | NA | NA |
| NT5C2 | fluorouracil | 0.1033367 | 0.7599893 | 0.10334 | NA | NA |
| DPYD | afatinib | 0.1034804 | 0.7599893 | 0.10348 | NA | NA |
| ABL1 | trametinib | 0.1038508 | 0.7599893 | 0.10385 | NA | NA |
| HRAS | azd | 0.1038879 | 0.7599893 | 0.10389 | NA | NA |
| WHSC1 | cabozantinib | 0.1045013 | 0.7599893 | 0.10450 | NA | NA |
| JAK3 | vandetanib | 0.1045969 | 0.7599893 | 0.10460 | NA | NA |
| MGMT | imatinib | 0.1047274 | 0.7599893 | 0.10473 | NA | NA |
| PHF6 | sunitinib | 0.1049670 | 0.7599893 | 0.10497 | NA | NA |
| DPYD | vandetanib | 0.1050806 | 0.7599893 | 0.10508 | NA | NA |
| EZH2 | sunitinib | 0.1053449 | 0.7599893 | 0.10534 | NA | NA |
| CDK4 | trametinib | 0.1055733 | 0.7599893 | 0.10557 | NA | NA |
| SRSF2 | vandetanib | 0.1055742 | 0.7599893 | 0.10557 | NA | NA |
| SF1 | vemurafenib | 0.1055962 | 0.7599893 | 0.10560 | NA | NA |
| CXCR4 | neratinib | 0.1062246 | 0.7608291 | 0.10622 | NA | NA |
| GNA11 | fulvestrant | 0.1064421 | 0.7608291 | 0.10644 | NA | NA |
| CXCR4 | azd | 0.1065396 | 0.7608291 | 0.10654 | NA | NA |
| NOTCH1 | fulvestrant | 0.1070302 | 0.7608291 | 0.10703 | NA | NA |
| STAT3 | imatinib | 0.1071208 | 0.7608291 | 0.10712 | NA | NA |
| AR | trametinib | 0.1075006 | 0.7608291 | 0.10750 | NA | NA |
| ATM | ruxolitinib | 0.1077925 | 0.7608291 | 0.10779 | NA | NA |
| CDK4 | azd | 0.1079284 | 0.7608291 | 0.10793 | NA | NA |
| WHSC1 | sunitinib | 0.1079484 | 0.7608291 | 0.10795 | NA | NA |
| FGFR1 | sunitinib | 0.1079957 | 0.7608291 | 0.10800 | NA | NA |
| PTEN | belinostat | 0.1081007 | 0.7608291 | 0.10810 | NA | NA |
| AKT3 | vemurafenib | 0.1087395 | 0.7627504 | 0.10874 | NA | NA |
| PDGFB | ibrutinib | 0.1088089 | 0.7627504 | 0.10881 | NA | NA |
| MGMT | erlotinib | 0.1093037 | 0.7637859 | 0.10930 | NA | NA |
| AKT1 | crizotinib | 0.1095589 | 0.7637859 | 0.10956 | NA | NA |
| PRPF40B | imatinib | 0.1098756 | 0.7637859 | 0.10988 | NA | NA |
| TP53 | fulvestrant | 0.1099325 | 0.7637859 | 0.10993 | NA | NA |
| NCOA2 | sunitinib | 0.1100462 | 0.7637859 | 0.11005 | NA | NA |
| DNAJB1 | cabozantinib | 0.1109801 | 0.7687458 | 0.11098 | NA | NA |
| DNAJB1 | pazopanib | 0.1112445 | 0.7690568 | 0.11124 | NA | NA |
| RUNX1 | temozolomide | 0.1120087 | 0.7693865 | 0.11201 | NA | NA |
| AKT1 | azd | 0.1125486 | 0.7693865 | 0.11255 | NA | NA |
| JAK1 | imatinib | 0.1127175 | 0.7693865 | 0.11272 | NA | NA |
| CBLB | cabozantinib | 0.1128859 | 0.7693865 | 0.11289 | NA | NA |
| RET | trametinib | 0.1129218 | 0.7693865 | 0.11292 | NA | NA |
| CTNNB1 | ibrutinib | 0.1129585 | 0.7693865 | 0.11296 | NA | NA |
| ATM | cyclophosphamide | 0.1129954 | 0.7693865 | 0.11300 | NA | NA |
| CREBBP | erlotinib | 0.1130482 | 0.7693865 | 0.11305 | NA | NA |
| XPO1 | sunitinib | 0.1137602 | 0.7727313 | 0.11376 | NA | NA |
| UGT1A1 | dabrafenib | 0.1142522 | 0.7745723 | 0.11425 | NA | NA |
| MDM2 | trametinib | 0.1144784 | 0.7746075 | 0.11448 | NA | NA |
| ESR1 | fluorouracil | 0.1147435 | 0.7749053 | 0.11474 | NA | NA |
| DNMT3A | pazopanib | 0.1153640 | 0.7754314 | 0.11536 | NA | NA |
| GNAQ | cabozantinib | 0.1156745 | 0.7754314 | 0.11567 | NA | NA |
| AKT2 | regorafenib | 0.1158322 | 0.7754314 | 0.11583 | NA | NA |
| FANCL | ruxolitinib | 0.1160798 | 0.7754314 | 0.11608 | NA | NA |
| PDGFB | vemurafenib | 0.1163543 | 0.7754314 | 0.11635 | NA | NA |
| GNAQ | lapatinib | 0.1165022 | 0.7754314 | 0.11650 | NA | NA |
| SF3B1 | selumetinib | 0.1165553 | 0.7754314 | 0.11656 | NA | NA |
| PTCH1 | lapatinib | 0.1167103 | 0.7754314 | 0.11671 | NA | NA |
| PTPN11 | azd | 0.1170068 | 0.7754314 | 0.11701 | NA | NA |
| PRPF40B | nilotinib | 0.1174956 | 0.7754314 | 0.11750 | NA | NA |
| EGF | olaparib | 0.1175606 | 0.7754314 | 0.11756 | NA | NA |
| BCORL1 | cabozantinib | 0.1177980 | 0.7754314 | 0.11780 | NA | NA |
| RIT1 | fulvestrant | 0.1178308 | 0.7754314 | 0.11783 | NA | NA |
| CALR | nilotinib | 0.1179187 | 0.7754314 | 0.11792 | NA | NA |
| DNAJB1 | ruxolitinib | 0.1183390 | 0.7758904 | 0.11834 | NA | NA |
| IL7R | trametinib | 0.1184312 | 0.7758904 | 0.11843 | NA | NA |
| FLCN | gefitinib | 0.1191367 | 0.7778584 | 0.11914 | NA | NA |
| PRPF40B | vandetanib | 0.1193475 | 0.7778584 | 0.11935 | NA | NA |
| CALR | cabozantinib | 0.1193974 | 0.7778584 | 0.11940 | NA | NA |
| AKT1 | sunitinib | 0.1198936 | 0.7786776 | 0.11989 | NA | NA |
| CSF3R | ibrutinib | 0.1199675 | 0.7786776 | 0.11997 | NA | NA |
| RIT1 | ruxolitinib | 0.1202230 | 0.7788938 | 0.12022 | NA | NA |
| CALR | gefitinib | 0.1208131 | 0.7802932 | 0.12081 | NA | NA |
| PDGFRA | azd | 0.1211302 | 0.7802932 | 0.12113 | NA | NA |
| PTPN11 | dabrafenib | 0.1213506 | 0.7802932 | 0.12135 | NA | NA |
| FLCN | imatinib | 0.1214437 | 0.7802932 | 0.12144 | NA | NA |
| CDKN2A | imatinib | 0.1217181 | 0.7802932 | 0.12172 | NA | NA |
| FLCN | fulvestrant | 0.1219799 | 0.7802932 | 0.12198 | NA | NA |
| SMO | fluorouracil | 0.1219973 | 0.7802932 | 0.12200 | NA | NA |
| DNAJB1 | erlotinib | 0.1232005 | 0.7865533 | 0.12320 | NA | NA |
| HRAS | olaparib | 0.1237067 | 0.7870376 | 0.12371 | NA | NA |
| ASXL1 | selumetinib | 0.1239994 | 0.7870376 | 0.12400 | NA | NA |
| BRCA1 | nilotinib | 0.1242641 | 0.7870376 | 0.12426 | NA | NA |
| PTPN11 | erlotinib | 0.1243777 | 0.7870376 | 0.12438 | NA | NA |
| TPMT | neratinib | 0.1244008 | 0.7870376 | 0.12440 | NA | NA |
| IDH1 | selumetinib | 0.1247711 | 0.7870376 | 0.12477 | NA | NA |
| TSC1 | cabozantinib | 0.1252422 | 0.7870376 | 0.12524 | NA | NA |
| FBXW7 | gefitinib | 0.1252959 | 0.7870376 | 0.12530 | NA | NA |
| RUNX1 | trametinib | 0.1255265 | 0.7870376 | 0.12553 | NA | NA |
| PML | gefitinib | 0.1255530 | 0.7870376 | 0.12555 | NA | NA |
| ERBB2 | fluorouracil | 0.1257464 | 0.7870376 | 0.12575 | NA | NA |
| AKT3 | nilotinib | 0.1260754 | 0.7873526 | 0.12608 | NA | NA |
| MYCN | trametinib | 0.1265565 | 0.7873526 | 0.12656 | NA | NA |
| CTNNB1 | vemurafenib | 0.1267129 | 0.7873526 | 0.12671 | NA | NA |
| TP53 | nilotinib | 0.1268691 | 0.7873526 | 0.12687 | NA | NA |
| CYP19A1 | ibrutinib | 0.1269984 | 0.7873526 | 0.12700 | NA | NA |
| CYP19A1 | dabrafenib | 0.1271974 | 0.7873526 | 0.12720 | NA | NA |
| ALK | ibrutinib | 0.1274241 | 0.7873526 | 0.12742 | NA | NA |
| PTCH1 | nilotinib | 0.1277181 | 0.7873526 | 0.12772 | NA | NA |
| GATA2 | azd | 0.1278184 | 0.7873526 | 0.12782 | NA | NA |
| SMC3 | trametinib | 0.1282147 | 0.7877273 | 0.12821 | NA | NA |
| PRPF40B | cabozantinib | 0.1285131 | 0.7877273 | 0.12851 | NA | NA |
| FGFR2 | fulvestrant | 0.1285535 | 0.7877273 | 0.12855 | NA | NA |
| VHL | nilotinib | 0.1289789 | 0.7889547 | 0.12898 | NA | NA |
| MAP2K2 | trametinib | 0.1303953 | 0.7962289 | 0.13040 | NA | NA |
| NPM1 | erlotinib | 0.1307567 | 0.7966577 | 0.13076 | NA | NA |
| MAP2K1 | nilotinib | 0.1312132 | 0.7966577 | 0.13121 | NA | NA |
| RIT1 | imatinib | 0.1313416 | 0.7966577 | 0.13134 | NA | NA |
| SMC1A | gefitinib | 0.1315843 | 0.7966577 | 0.13158 | NA | NA |
| EGFR | trametinib | 0.1316155 | 0.7966577 | 0.13162 | NA | NA |
| NPM1 | sunitinib | 0.1320366 | 0.7966577 | 0.13204 | NA | NA |
| NOTCH2 | erlotinib | 0.1320565 | 0.7966577 | 0.13206 | NA | NA |
| ROS1 | regorafenib | 0.1323222 | 0.7968891 | 0.13232 | NA | NA |
| NT5C2 | afatinib | 0.1326113 | 0.7972602 | 0.13261 | NA | NA |
| JAK2 | vemurafenib | 0.1329072 | 0.7976706 | 0.13291 | NA | NA |
| KMT2A | nilotinib | 0.1337835 | 0.7981820 | 0.13378 | NA | NA |
| PIGA | lapatinib | 0.1341049 | 0.7981820 | 0.13410 | NA | NA |
| MAP2K2 | vemurafenib | 0.1342462 | 0.7981820 | 0.13425 | NA | NA |
| PRPF40B | sunitinib | 0.1344950 | 0.7981820 | 0.13450 | NA | NA |
| GNAS | nilotinib | 0.1345771 | 0.7981820 | 0.13458 | NA | NA |
| RPL10 | regorafenib | 0.1349031 | 0.7981820 | 0.13490 | NA | NA |
| ERBB4 | gefitinib | 0.1349667 | 0.7981820 | 0.13497 | NA | NA |
| WHSC1 | fluorouracil | 0.1350066 | 0.7981820 | 0.13501 | NA | NA |
| BRAF | imatinib | 0.1350841 | 0.7981820 | 0.13508 | NA | NA |
| FGFR1 | trametinib | 0.1354219 | 0.7981820 | 0.13542 | NA | NA |
| NOTCH2 | neratinib | 0.1355982 | 0.7981820 | 0.13560 | NA | NA |
| TP53 | dabrafenib | 0.1357251 | 0.7981820 | 0.13573 | NA | NA |
| MAP2K1 | belinostat | 0.1362402 | 0.7998691 | 0.13624 | NA | NA |
| PAX8 | ibrutinib | 0.1366591 | 0.8009867 | 0.13666 | NA | NA |
| BRCA2 | neratinib | 0.1369451 | 0.8013229 | 0.13695 | NA | NA |
| PTCH1 | olaparib | 0.1376429 | 0.8028709 | 0.13764 | NA | NA |
| CXCR4 | belinostat | 0.1376677 | 0.8028709 | 0.13767 | NA | NA |
| NRAS | imatinib | 0.1384091 | 0.8045501 | 0.13841 | NA | NA |
| CREBBP | nilotinib | 0.1384148 | 0.8045501 | 0.13841 | NA | NA |
| CD79B | dabrafenib | 0.1390400 | 0.8059781 | 0.13904 | NA | NA |
| BCOR | vemurafenib | 0.1391467 | 0.8059781 | 0.13915 | NA | NA |
| SMC3 | dasatinib | 0.1393503 | 0.8059781 | 0.13935 | NA | NA |
| PRPF8 | cabozantinib | 0.1398247 | 0.8073895 | 0.13982 | NA | NA |
| PHF6 | afatinib | 0.1404522 | 0.8078863 | 0.14045 | NA | NA |
| CRLF2 | crizotinib | 0.1405708 | 0.8078863 | 0.14057 | NA | NA |
| PIGA | vemurafenib | 0.1406472 | 0.8078863 | 0.14065 | NA | NA |
| TPMT | ruxolitinib | 0.1408874 | 0.8078863 | 0.14089 | NA | NA |
| SF3B1 | trametinib | 0.1410632 | 0.8078863 | 0.14106 | NA | NA |
| SMC1A | regorafenib | 0.1419292 | 0.8098874 | 0.14193 | NA | NA |
| HRAS | regorafenib | 0.1421163 | 0.8098874 | 0.14212 | NA | NA |
| IDH1 | lapatinib | 0.1421804 | 0.8098874 | 0.14218 | NA | NA |
| UGT1A1 | selumetinib | 0.1423368 | 0.8098874 | 0.14234 | NA | NA |
| NOTCH1 | sunitinib | 0.1427914 | 0.8105372 | 0.14279 | NA | NA |
| BCORL1 | trametinib | 0.1429136 | 0.8105372 | 0.14291 | NA | NA |
| MGMT | fluorouracil | 0.1432551 | 0.8111616 | 0.14326 | NA | NA |
| PTPN11 | imatinib | 0.1438706 | 0.8133332 | 0.14387 | NA | NA |
| MAP2K2 | fluorouracil | 0.1451351 | 0.8139669 | 0.14514 | NA | NA |
| DNAJB1 | lapatinib | 0.1453252 | 0.8139669 | 0.14533 | NA | NA |
| BRCA2 | erlotinib | 0.1458082 | 0.8139669 | 0.14581 | NA | NA |
| PIGA | nilotinib | 0.1458103 | 0.8139669 | 0.14581 | NA | NA |
| ALK | erlotinib | 0.1462901 | 0.8139669 | 0.14629 | NA | NA |
| CDK4 | ruxolitinib | 0.1466623 | 0.8139669 | 0.14666 | NA | NA |
| CDC73 | erlotinib | 0.1471099 | 0.8139669 | 0.14711 | NA | NA |
| NRAS | pazopanib | 0.1471822 | 0.8139669 | 0.14718 | NA | NA |
| FLT3 | nilotinib | 0.1476259 | 0.8139669 | 0.14763 | NA | NA |
| SH2B3 | azd | 0.1476460 | 0.8139669 | 0.14765 | NA | NA |
| DPYD | nilotinib | 0.1476663 | 0.8139669 | 0.14767 | NA | NA |
| CXCR4 | sunitinib | 0.1478791 | 0.8139669 | 0.14788 | NA | NA |
| PRPF40B | pazopanib | 0.1481602 | 0.8139669 | 0.14816 | NA | NA |
| CTNNB1 | azd | 0.1486690 | 0.8139669 | 0.14867 | NA | NA |
| WT1 | dabrafenib | 0.1487594 | 0.8139669 | 0.14876 | NA | NA |
| SMC3 | temozolomide | 0.1491969 | 0.8139669 | 0.14920 | NA | NA |
| BCORL1 | dabrafenib | 0.1492104 | 0.8139669 | 0.14921 | NA | NA |
| FLCN | temozolomide | 0.1492541 | 0.8139669 | 0.14925 | NA | NA |
| GATA2 | pazopanib | 0.1494006 | 0.8139669 | 0.14940 | NA | NA |
| FBXW7 | fulvestrant | 0.1495816 | 0.8139669 | 0.14958 | NA | NA |
| PIK3CA | regorafenib | 0.1496344 | 0.8139669 | 0.14963 | NA | NA |
| G6PD | trametinib | 0.1496537 | 0.8139669 | 0.14965 | NA | NA |
| GATA2 | temozolomide | 0.1499759 | 0.8139669 | 0.14998 | NA | NA |
| CALR | ruxolitinib | 0.1502069 | 0.8139669 | 0.15021 | NA | NA |
| CTCF | dabrafenib | 0.1505836 | 0.8139669 | 0.15058 | NA | NA |
| NOTCH2 | azd | 0.1511979 | 0.8139669 | 0.15120 | NA | NA |
| GNAS | imatinib | 0.1513761 | 0.8139669 | 0.15138 | NA | NA |
| FBXW7 | dasatinib | 0.1515082 | 0.8139669 | 0.15151 | NA | NA |
| FGFR2 | vandetanib | 0.1516630 | 0.8139669 | 0.15166 | NA | NA |
| TSC1 | sunitinib | 0.1518085 | 0.8139669 | 0.15181 | NA | NA |
| RIT1 | olaparib | 0.1523414 | 0.8139669 | 0.15234 | NA | NA |
| ASXL1 | cabozantinib | 0.1523643 | 0.8139669 | 0.15236 | NA | NA |
| RIT1 | vandetanib | 0.1526440 | 0.8139669 | 0.15264 | NA | NA |
| PRPF8 | regorafenib | 0.1527561 | 0.8139669 | 0.15276 | NA | NA |
| AKT1 | neratinib | 0.1528627 | 0.8139669 | 0.15286 | NA | NA |
| DPYD | fulvestrant | 0.1532097 | 0.8139669 | 0.15321 | NA | NA |
| ERBB2 | erlotinib | 0.1533325 | 0.8139669 | 0.15333 | NA | NA |
| JAK3 | imatinib | 0.1536430 | 0.8139669 | 0.15364 | NA | NA |
| STAG2 | pazopanib | 0.1545538 | 0.8139669 | 0.15455 | NA | NA |
| AR | ruxolitinib | 0.1546453 | 0.8139669 | 0.15465 | NA | NA |
| CSF3R | selumetinib | 0.1547424 | 0.8139669 | 0.15474 | NA | NA |
| SH2B3 | vandetanib | 0.1547989 | 0.8139669 | 0.15480 | NA | NA |
| CDKN2A | nilotinib | 0.1548829 | 0.8139669 | 0.15488 | NA | NA |
| G6PD | selumetinib | 0.1551003 | 0.8139669 | 0.15510 | NA | NA |
| PAX8 | temozolomide | 0.1555864 | 0.8139669 | 0.15559 | NA | NA |
| PTPN11 | vandetanib | 0.1562055 | 0.8139669 | 0.15621 | NA | NA |
| PDGFRB | selumetinib | 0.1562725 | 0.8139669 | 0.15627 | NA | NA |
| SETD2 | dasatinib | 0.1567577 | 0.8139669 | 0.15676 | NA | NA |
| SF1 | temozolomide | 0.1568007 | 0.8139669 | 0.15680 | NA | NA |
| FBXW7 | pazopanib | 0.1570251 | 0.8139669 | 0.15703 | NA | NA |
| ALK | azd | 0.1572449 | 0.8139669 | 0.15724 | NA | NA |
| PAX8 | belinostat | 0.1576880 | 0.8139669 | 0.15769 | NA | NA |
| FLT3 | vemurafenib | 0.1577275 | 0.8139669 | 0.15773 | NA | NA |
| SRSF2 | ibrutinib | 0.1577676 | 0.8139669 | 0.15777 | NA | NA |
| NPM1 | crizotinib | 0.1583886 | 0.8139669 | 0.15839 | NA | NA |
| CYP19A1 | fluorouracil | 0.1588485 | 0.8139669 | 0.15885 | NA | NA |
| DNMT3A | dasatinib | 0.1589015 | 0.8139669 | 0.15890 | NA | NA |
| NCOA2 | cabozantinib | 0.1589077 | 0.8139669 | 0.15891 | NA | NA |
| CTLA4 | vemurafenib | 0.1591235 | 0.8139669 | 0.15912 | NA | NA |
| ALK | selumetinib | 0.1591782 | 0.8139669 | 0.15918 | NA | NA |
| MPL | selumetinib | 0.1593342 | 0.8139669 | 0.15933 | NA | NA |
| CDK4 | regorafenib | 0.1593708 | 0.8139669 | 0.15937 | NA | NA |
| FANCL | sunitinib | 0.1594357 | 0.8139669 | 0.15944 | NA | NA |
| JAK1 | erlotinib | 0.1595117 | 0.8139669 | 0.15951 | NA | NA |
| SETBP1 | lapatinib | 0.1597840 | 0.8139669 | 0.15978 | NA | NA |
| KIT | erlotinib | 0.1599953 | 0.8139669 | 0.16000 | NA | NA |
| ASXL1 | fulvestrant | 0.1600019 | 0.8139669 | 0.16000 | NA | NA |
| CYP19A1 | belinostat | 0.1605668 | 0.8139669 | 0.16057 | NA | NA |
| UGT1A1 | olaparib | 0.1608514 | 0.8139669 | 0.16085 | NA | NA |
| IL7R | selumetinib | 0.1611103 | 0.8139669 | 0.16111 | NA | NA |
| RIT1 | gefitinib | 0.1611659 | 0.8139669 | 0.16117 | NA | NA |
| CSF3R | neratinib | 0.1612767 | 0.8139669 | 0.16128 | NA | NA |
| FBXW7 | imatinib | 0.1616916 | 0.8139669 | 0.16169 | NA | NA |
| NOTCH2 | regorafenib | 0.1621855 | 0.8139669 | 0.16219 | NA | NA |
| KMT2A | fluorouracil | 0.1623496 | 0.8139669 | 0.16235 | NA | NA |
| ABL1 | ruxolitinib | 0.1623760 | 0.8139669 | 0.16238 | NA | NA |
| CTNNB1 | fulvestrant | 0.1624991 | 0.8139669 | 0.16250 | NA | NA |
| PDGFRA | sunitinib | 0.1625269 | 0.8139669 | 0.16253 | NA | NA |
| SRSF2 | lapatinib | 0.1626520 | 0.8139669 | 0.16265 | NA | NA |
| AKT1 | vemurafenib | 0.1629510 | 0.8139669 | 0.16295 | NA | NA |
| CYP19A1 | nilotinib | 0.1633178 | 0.8139669 | 0.16332 | NA | NA |
| CDK4 | cabozantinib | 0.1633468 | 0.8139669 | 0.16335 | NA | NA |
| RET | lapatinib | 0.1635140 | 0.8139669 | 0.16351 | NA | NA |
| EGF | selumetinib | 0.1635275 | 0.8139669 | 0.16353 | NA | NA |
| SMC3 | azd | 0.1637223 | 0.8139669 | 0.16372 | NA | NA |
| GATA3 | vemurafenib | 0.1643528 | 0.8159440 | 0.16435 | NA | NA |
| ROS1 | ruxolitinib | 0.1652562 | 0.8181245 | 0.16526 | NA | NA |
| TPMT | gefitinib | 0.1653865 | 0.8181245 | 0.16539 | NA | NA |
| VHL | lapatinib | 0.1657053 | 0.8181245 | 0.16571 | NA | NA |
| ERBB4 | erlotinib | 0.1663518 | 0.8181245 | 0.16635 | NA | NA |
| CTLA4 | ibrutinib | 0.1663882 | 0.8181245 | 0.16639 | NA | NA |
| CYP19A1 | cyclophosphamide | 0.1664216 | 0.8181245 | 0.16642 | NA | NA |
| HRAS | neratinib | 0.1666057 | 0.8181245 | 0.16661 | NA | NA |
| FANCL | imatinib | 0.1666593 | 0.8181245 | 0.16666 | NA | NA |
| DNAJB1 | azd | 0.1671200 | 0.8183088 | 0.16712 | NA | NA |
| MET | cyclophosphamide | 0.1671638 | 0.8183088 | 0.16716 | NA | NA |
| MGMT | temozolomide | 0.1678755 | 0.8199784 | 0.16788 | NA | NA |
| ERBB2 | dasatinib | 0.1679727 | 0.8199784 | 0.16797 | NA | NA |
| TSC1 | neratinib | 0.1690040 | 0.8215360 | 0.16900 | NA | NA |
| RET | vandetanib | 0.1691629 | 0.8215360 | 0.16916 | NA | NA |
| CREBBP | gefitinib | 0.1695092 | 0.8215360 | 0.16951 | NA | NA |
| MAP2K2 | erlotinib | 0.1698711 | 0.8215360 | 0.16987 | NA | NA |
| CXCR4 | crizotinib | 0.1699645 | 0.8215360 | 0.16996 | NA | NA |
| AKT2 | gefitinib | 0.1702013 | 0.8215360 | 0.17020 | NA | NA |
| RIT1 | ibrutinib | 0.1702498 | 0.8215360 | 0.17025 | NA | NA |
| DNAJB1 | crizotinib | 0.1706317 | 0.8215360 | 0.17063 | NA | NA |
| PTPN11 | trametinib | 0.1708413 | 0.8215360 | 0.17084 | NA | NA |
| PIGA | ruxolitinib | 0.1710802 | 0.8215360 | 0.17108 | NA | NA |
| CTCF | afatinib | 0.1713970 | 0.8215360 | 0.17140 | NA | NA |
| SSX1 | cyclophosphamide | 0.1714083 | 0.8215360 | 0.17141 | NA | NA |
| ROS1 | afatinib | 0.1715284 | 0.8215360 | 0.17153 | NA | NA |
| CSF3R | nilotinib | 0.1715733 | 0.8215360 | 0.17157 | NA | NA |
| RPL10 | nilotinib | 0.1720057 | 0.8217034 | 0.17201 | NA | NA |
| ALK | fluorouracil | 0.1722690 | 0.8217034 | 0.17227 | NA | NA |
| FLCN | nilotinib | 0.1723116 | 0.8217034 | 0.17231 | NA | NA |
| EED | imatinib | 0.1727877 | 0.8224847 | 0.17279 | NA | NA |
| JAK1 | cyclophosphamide | 0.1731296 | 0.8224847 | 0.17313 | NA | NA |
| PTPN11 | lapatinib | 0.1732828 | 0.8224847 | 0.17328 | NA | NA |
| IL7R | fulvestrant | 0.1739823 | 0.8224847 | 0.17398 | NA | NA |
| BTK | temozolomide | 0.1743973 | 0.8224847 | 0.17440 | NA | NA |
| STAT3 | vandetanib | 0.1745649 | 0.8224847 | 0.17456 | NA | NA |
| RAD21 | gefitinib | 0.1746775 | 0.8224847 | 0.17468 | NA | NA |
| FBXW7 | afatinib | 0.1748361 | 0.8224847 | 0.17484 | NA | NA |
| EGF | pazopanib | 0.1752988 | 0.8224847 | 0.17530 | NA | NA |
| MYCN | dasatinib | 0.1756074 | 0.8224847 | 0.17561 | NA | NA |
| AKT3 | imatinib | 0.1756744 | 0.8224847 | 0.17567 | NA | NA |
| EGF | vandetanib | 0.1756788 | 0.8224847 | 0.17568 | NA | NA |
| CXCR4 | temozolomide | 0.1757492 | 0.8224847 | 0.17575 | NA | NA |
| CDC73 | gefitinib | 0.1759263 | 0.8224847 | 0.17593 | NA | NA |
| IDH2 | fulvestrant | 0.1760724 | 0.8224847 | 0.17607 | NA | NA |
| BRCA2 | selumetinib | 0.1762300 | 0.8224847 | 0.17623 | NA | NA |
| CBLB | temozolomide | 0.1766069 | 0.8228117 | 0.17661 | NA | NA |
| GATA2 | sunitinib | 0.1769371 | 0.8228117 | 0.17694 | NA | NA |
| IDH2 | imatinib | 0.1770530 | 0.8228117 | 0.17705 | NA | NA |
| IDH1 | regorafenib | 0.1775547 | 0.8228117 | 0.17755 | NA | NA |
| VHL | temozolomide | 0.1776761 | 0.8228117 | 0.17768 | NA | NA |
| GNAS | belinostat | 0.1778414 | 0.8228117 | 0.17784 | NA | NA |
| GNA11 | vemurafenib | 0.1779433 | 0.8228117 | 0.17794 | NA | NA |
| CD274 | olaparib | 0.1782599 | 0.8231897 | 0.17826 | NA | NA |
| RIT1 | crizotinib | 0.1790213 | 0.8256178 | 0.17902 | NA | NA |
| TSC1 | dabrafenib | 0.1796741 | 0.8270773 | 0.17967 | NA | NA |
| ABL1 | belinostat | 0.1800207 | 0.8270773 | 0.18002 | NA | NA |
| SETBP1 | gefitinib | 0.1801410 | 0.8270773 | 0.18014 | NA | NA |
| CBLB | vemurafenib | 0.1802816 | 0.8270773 | 0.18028 | NA | NA |
| G6PD | gefitinib | 0.1809687 | 0.8276715 | 0.18097 | NA | NA |
| PDGFRB | pazopanib | 0.1809713 | 0.8276715 | 0.18097 | NA | NA |
| GNAQ | vandetanib | 0.1818330 | 0.8276715 | 0.18183 | NA | NA |
| ALK | lapatinib | 0.1820481 | 0.8276715 | 0.18205 | NA | NA |
| KIT | pazopanib | 0.1823374 | 0.8276715 | 0.18234 | NA | NA |
| ERBB4 | cabozantinib | 0.1825959 | 0.8276715 | 0.18260 | NA | NA |
| ATM | vemurafenib | 0.1826621 | 0.8276715 | 0.18266 | NA | NA |
| UGT1A1 | cyclophosphamide | 0.1827105 | 0.8276715 | 0.18271 | NA | NA |
| SMO | regorafenib | 0.1829769 | 0.8276715 | 0.18298 | NA | NA |
| JAK1 | temozolomide | 0.1831782 | 0.8276715 | 0.18318 | NA | NA |
| RAD21 | cabozantinib | 0.1832088 | 0.8276715 | 0.18321 | NA | NA |
| CD274 | fluorouracil | 0.1835994 | 0.8276715 | 0.18360 | NA | NA |
| ESR1 | trametinib | 0.1839575 | 0.8276715 | 0.18396 | NA | NA |
| CYP19A1 | sunitinib | 0.1840148 | 0.8276715 | 0.18401 | NA | NA |
| FANCL | nilotinib | 0.1843329 | 0.8276715 | 0.18433 | NA | NA |
| PIGA | erlotinib | 0.1843881 | 0.8276715 | 0.18439 | NA | NA |
| CTCF | gefitinib | 0.1844255 | 0.8276715 | 0.18443 | NA | NA |
| RET | ruxolitinib | 0.1851983 | 0.8300768 | 0.18520 | NA | NA |
| FLCN | sunitinib | 0.1855494 | 0.8302316 | 0.18555 | NA | NA |
| MET | fulvestrant | 0.1858576 | 0.8302316 | 0.18586 | NA | NA |
| VHL | dabrafenib | 0.1868603 | 0.8302316 | 0.18686 | NA | NA |
| U2AF1 | selumetinib | 0.1868736 | 0.8302316 | 0.18687 | NA | NA |
| CD274 | crizotinib | 0.1869796 | 0.8302316 | 0.18698 | NA | NA |
| PRPF40B | neratinib | 0.1873324 | 0.8302316 | 0.18733 | NA | NA |
| CSF3R | imatinib | 0.1873940 | 0.8302316 | 0.18739 | NA | NA |
| MAP2K1 | ibrutinib | 0.1879374 | 0.8302316 | 0.18794 | NA | NA |
| ASXL1 | nilotinib | 0.1880436 | 0.8302316 | 0.18804 | NA | NA |
| KMT2A | dasatinib | 0.1882251 | 0.8302316 | 0.18823 | NA | NA |
| ALK | temozolomide | 0.1882566 | 0.8302316 | 0.18826 | NA | NA |
| PTPN11 | temozolomide | 0.1884716 | 0.8302316 | 0.18847 | NA | NA |
| PAX8 | erlotinib | 0.1884806 | 0.8302316 | 0.18848 | NA | NA |
| CALR | cyclophosphamide | 0.1885490 | 0.8302316 | 0.18855 | NA | NA |
| CALR | afatinib | 0.1902247 | 0.8348867 | 0.19022 | NA | NA |
| IDH1 | cyclophosphamide | 0.1903190 | 0.8348867 | 0.19032 | NA | NA |
| PDGFRA | trametinib | 0.1903208 | 0.8348867 | 0.19032 | NA | NA |
| SRSF2 | trametinib | 0.1909143 | 0.8349555 | 0.19091 | NA | NA |
| MGMT | vandetanib | 0.1909706 | 0.8349555 | 0.19097 | NA | NA |
| JAK2 | azd | 0.1912155 | 0.8349555 | 0.19122 | NA | NA |
| MYCN | nilotinib | 0.1912894 | 0.8349555 | 0.19129 | NA | NA |
| CXCR4 | dasatinib | 0.1917449 | 0.8352892 | 0.19174 | NA | NA |
| BCORL1 | erlotinib | 0.1918424 | 0.8352892 | 0.19184 | NA | NA |
| RAD21 | fluorouracil | 0.1924574 | 0.8360782 | 0.19246 | NA | NA |
| PTPN11 | ibrutinib | 0.1925193 | 0.8360782 | 0.19252 | NA | NA |
| CXCR4 | cabozantinib | 0.1928962 | 0.8360782 | 0.19290 | NA | NA |
| DNAJB1 | dabrafenib | 0.1934385 | 0.8360782 | 0.19344 | NA | NA |
| JAK3 | olaparib | 0.1935261 | 0.8360782 | 0.19353 | NA | NA |
| STAT3 | afatinib | 0.1935875 | 0.8360782 | 0.19359 | NA | NA |
| ETV6 | temozolomide | 0.1938471 | 0.8360782 | 0.19385 | NA | NA |
| CD79B | ruxolitinib | 0.1939320 | 0.8360782 | 0.19393 | NA | NA |
| RUNX1 | erlotinib | 0.1942156 | 0.8361799 | 0.19422 | NA | NA |
| NT5C2 | imatinib | 0.1944327 | 0.8361799 | 0.19443 | NA | NA |
| ASXL1 | gefitinib | 0.1953168 | 0.8366549 | 0.19532 | NA | NA |
| HRAS | fulvestrant | 0.1953622 | 0.8366549 | 0.19536 | NA | NA |
| U2AF1 | neratinib | 0.1953924 | 0.8366549 | 0.19539 | NA | NA |
| EZH2 | cabozantinib | 0.1954980 | 0.8366549 | 0.19550 | NA | NA |
| FANCL | pazopanib | 0.1961635 | 0.8368360 | 0.19616 | NA | NA |
| PRPF8 | temozolomide | 0.1962058 | 0.8368360 | 0.19621 | NA | NA |
| ERBB2 | afatinib | 0.1962848 | 0.8368360 | 0.19628 | NA | NA |
| SETBP1 | vandetanib | 0.1965746 | 0.8368360 | 0.19657 | NA | NA |
| PHF6 | crizotinib | 0.1969099 | 0.8368360 | 0.19691 | NA | NA |
| FGFR1 | gefitinib | 0.1970554 | 0.8368360 | 0.19706 | NA | NA |
| DPYD | vemurafenib | 0.1972116 | 0.8368360 | 0.19721 | NA | NA |
| JAK3 | cyclophosphamide | 0.1976407 | 0.8376427 | 0.19764 | NA | NA |
| DNAJB1 | cyclophosphamide | 0.1981339 | 0.8387190 | 0.19813 | NA | NA |
| BRCA1 | cabozantinib | 0.1984399 | 0.8390008 | 0.19844 | NA | NA |
| GATA1 | cabozantinib | 0.1987349 | 0.8392360 | 0.19873 | NA | NA |
| NCOA2 | pazopanib | 0.1998764 | 0.8399864 | 0.19988 | NA | NA |
| RIT1 | regorafenib | 0.1999553 | 0.8399864 | 0.19996 | NA | NA |
| GNA11 | neratinib | 0.2002192 | 0.8399864 | 0.20022 | NA | NA |
| IDH2 | afatinib | 0.2002219 | 0.8399864 | 0.20022 | NA | NA |
| GATA1 | sunitinib | 0.2003370 | 0.8399864 | 0.20034 | NA | NA |
| PIGA | belinostat | 0.2003505 | 0.8399864 | 0.20035 | NA | NA |
| GNA11 | nilotinib | 0.2010245 | 0.8416504 | 0.20102 | NA | NA |
| CDK4 | fulvestrant | 0.2012277 | 0.8416504 | 0.20123 | NA | NA |
| IL7R | azd | 0.2028546 | 0.8429577 | 0.20285 | NA | NA |
| CSF3R | azd | 0.2028828 | 0.8429577 | 0.20288 | NA | NA |
| BRCA1 | sunitinib | 0.2029629 | 0.8429577 | 0.20296 | NA | NA |
| FBXW7 | fluorouracil | 0.2029792 | 0.8429577 | 0.20298 | NA | NA |
| STAG2 | dabrafenib | 0.2040979 | 0.8429577 | 0.20410 | NA | NA |
| PTCH1 | cabozantinib | 0.2043150 | 0.8429577 | 0.20432 | NA | NA |
| KRAS | temozolomide | 0.2044885 | 0.8429577 | 0.20449 | NA | NA |
| SETBP1 | temozolomide | 0.2047547 | 0.8429577 | 0.20475 | NA | NA |
| RET | gefitinib | 0.2049189 | 0.8429577 | 0.20492 | NA | NA |
| JAK1 | selumetinib | 0.2050591 | 0.8429577 | 0.20506 | NA | NA |
| PTEN | ruxolitinib | 0.2051818 | 0.8429577 | 0.20518 | NA | NA |
| CTNNB1 | temozolomide | 0.2056164 | 0.8429577 | 0.20562 | NA | NA |
| STAT3 | regorafenib | 0.2056564 | 0.8429577 | 0.20566 | NA | NA |
| JAK2 | vandetanib | 0.2056568 | 0.8429577 | 0.20566 | NA | NA |
| NT5C2 | regorafenib | 0.2063329 | 0.8429577 | 0.20633 | NA | NA |
| TPMT | lapatinib | 0.2063631 | 0.8429577 | 0.20636 | NA | NA |
| BTK | fulvestrant | 0.2063932 | 0.8429577 | 0.20639 | NA | NA |
| ERBB2 | neratinib | 0.2066706 | 0.8429577 | 0.20667 | NA | NA |
| SETBP1 | dabrafenib | 0.2068304 | 0.8429577 | 0.20683 | NA | NA |
| ERBB4 | regorafenib | 0.2068637 | 0.8429577 | 0.20686 | NA | NA |
| STAT3 | ibrutinib | 0.2071369 | 0.8429577 | 0.20714 | NA | NA |
| BCORL1 | belinostat | 0.2074537 | 0.8429577 | 0.20745 | NA | NA |
| GATA2 | ibrutinib | 0.2077625 | 0.8429577 | 0.20776 | NA | NA |
| JAK3 | lapatinib | 0.2077682 | 0.8429577 | 0.20777 | NA | NA |
| ABL1 | temozolomide | 0.2078183 | 0.8429577 | 0.20782 | NA | NA |
| NCOA2 | fulvestrant | 0.2080174 | 0.8429577 | 0.20802 | NA | NA |
| CTNNB1 | gefitinib | 0.2081323 | 0.8429577 | 0.20813 | NA | NA |
| G6PD | vandetanib | 0.2082743 | 0.8429577 | 0.20827 | NA | NA |
| EGF | ibrutinib | 0.2085764 | 0.8432069 | 0.20858 | NA | NA |
| DDIT3 | dasatinib | 0.2089324 | 0.8436728 | 0.20893 | NA | NA |
| PIGA | fluorouracil | 0.2097762 | 0.8460392 | 0.20978 | NA | NA |
| CDKN2A | ibrutinib | 0.2100012 | 0.8460392 | 0.21000 | NA | NA |
| PDGFB | ruxolitinib | 0.2112854 | 0.8502356 | 0.21129 | NA | NA |
| JAK2 | regorafenib | 0.2116803 | 0.8503640 | 0.21168 | NA | NA |
| MGMT | afatinib | 0.2118025 | 0.8503640 | 0.21180 | NA | NA |
| CBL | crizotinib | 0.2125045 | 0.8517609 | 0.21250 | NA | NA |
| CALR | ibrutinib | 0.2126741 | 0.8517609 | 0.21267 | NA | NA |
| MPL | temozolomide | 0.2133527 | 0.8517609 | 0.21335 | NA | NA |
| RUNX1 | imatinib | 0.2134733 | 0.8517609 | 0.21347 | NA | NA |
| DNAJB1 | nilotinib | 0.2139098 | 0.8517609 | 0.21391 | NA | NA |
| TSC1 | ibrutinib | 0.2141178 | 0.8517609 | 0.21412 | NA | NA |
| CALR | pazopanib | 0.2141930 | 0.8517609 | 0.21419 | NA | NA |
| CDK4 | sunitinib | 0.2143020 | 0.8517609 | 0.21430 | NA | NA |
| CDK6 | dabrafenib | 0.2147605 | 0.8517609 | 0.21476 | NA | NA |
| XPO1 | dasatinib | 0.2148036 | 0.8517609 | 0.21480 | NA | NA |
| HRAS | vemurafenib | 0.2155713 | 0.8517609 | 0.21557 | NA | NA |
| RET | erlotinib | 0.2156089 | 0.8517609 | 0.21561 | NA | NA |
| NCOA2 | trametinib | 0.2156555 | 0.8517609 | 0.21566 | NA | NA |
| CTNNB1 | erlotinib | 0.2157214 | 0.8517609 | 0.21572 | NA | NA |
| CDK4 | lapatinib | 0.2157956 | 0.8517609 | 0.21580 | NA | NA |
| CD79B | sunitinib | 0.2161821 | 0.8520326 | 0.21618 | NA | NA |
| EGF | nilotinib | 0.2165890 | 0.8520326 | 0.21659 | NA | NA |
| SMC3 | olaparib | 0.2165937 | 0.8520326 | 0.21659 | NA | NA |
| MET | trametinib | 0.2171377 | 0.8532149 | 0.21714 | NA | NA |
| JAK1 | vandetanib | 0.2175356 | 0.8538211 | 0.21754 | NA | NA |
| CD79B | regorafenib | 0.2181528 | 0.8552857 | 0.21815 | NA | NA |
| TPMT | olaparib | 0.2193329 | 0.8585846 | 0.21933 | NA | NA |
| MET | vandetanib | 0.2195544 | 0.8585846 | 0.21955 | NA | NA |
| EGFR | azd | 0.2197291 | 0.8585846 | 0.21973 | NA | NA |
| UGT1A1 | crizotinib | 0.2205241 | 0.8602377 | 0.22052 | NA | NA |
| RPL10 | cabozantinib | 0.2206430 | 0.8602377 | 0.22064 | NA | NA |
| PDGFRA | cabozantinib | 0.2210144 | 0.8607283 | 0.22101 | NA | NA |
| AKT1 | erlotinib | 0.2216745 | 0.8611467 | 0.22167 | NA | NA |
| CDK6 | trametinib | 0.2219071 | 0.8611467 | 0.22191 | NA | NA |
| RUNX1 | selumetinib | 0.2219756 | 0.8611467 | 0.22198 | NA | NA |
| GATA3 | lapatinib | 0.2221046 | 0.8611467 | 0.22210 | NA | NA |
| XPO1 | dabrafenib | 0.2225415 | 0.8612441 | 0.22254 | NA | NA |
| RIT1 | afatinib | 0.2226212 | 0.8612441 | 0.22262 | NA | NA |
| CD79B | temozolomide | 0.2230203 | 0.8617012 | 0.22302 | NA | NA |
| ROS1 | lapatinib | 0.2232310 | 0.8617012 | 0.22323 | NA | NA |
| CSF3R | dabrafenib | 0.2243915 | 0.8646842 | 0.22439 | NA | NA |
| EGF | cabozantinib | 0.2251682 | 0.8646842 | 0.22517 | NA | NA |
| CD79B | vemurafenib | 0.2251826 | 0.8646842 | 0.22518 | NA | NA |
| AKT1 | vandetanib | 0.2252466 | 0.8646842 | 0.22525 | NA | NA |
| PDCD1 | lapatinib | 0.2254655 | 0.8646842 | 0.22547 | NA | NA |
| NOTCH1 | nilotinib | 0.2258924 | 0.8646842 | 0.22589 | NA | NA |
| DPYD | erlotinib | 0.2260758 | 0.8646842 | 0.22608 | NA | NA |
| MDM2 | gefitinib | 0.2261892 | 0.8646842 | 0.22619 | NA | NA |
| FANCL | trametinib | 0.2264859 | 0.8646842 | 0.22649 | NA | NA |
| TET2 | fulvestrant | 0.2267718 | 0.8646842 | 0.22677 | NA | NA |
| IDH2 | erlotinib | 0.2268140 | 0.8646842 | 0.22681 | NA | NA |
| MAP2K1 | cabozantinib | 0.2271271 | 0.8646842 | 0.22713 | NA | NA |
| KIT | neratinib | 0.2272109 | 0.8646842 | 0.22721 | NA | NA |
| NRAS | sunitinib | 0.2276144 | 0.8652805 | 0.22761 | NA | NA |
| PIGA | trametinib | 0.2279091 | 0.8654619 | 0.22791 | NA | NA |
| GNAS | ibrutinib | 0.2283673 | 0.8656530 | 0.22837 | NA | NA |
| AKT2 | erlotinib | 0.2285363 | 0.8656530 | 0.22854 | NA | NA |
| EGF | temozolomide | 0.2290065 | 0.8656530 | 0.22901 | NA | NA |
| CDKN2A | selumetinib | 0.2293566 | 0.8656530 | 0.22936 | NA | NA |
| TSC1 | azd | 0.2297525 | 0.8656530 | 0.22975 | NA | NA |
| SF3B1 | vandetanib | 0.2298798 | 0.8656530 | 0.22988 | NA | NA |
| CDK4 | selumetinib | 0.2302961 | 0.8656530 | 0.23030 | NA | NA |
| EZH2 | azd | 0.2304676 | 0.8656530 | 0.23047 | NA | NA |
| NRAS | ruxolitinib | 0.2305854 | 0.8656530 | 0.23059 | NA | NA |
| TET2 | pazopanib | 0.2306595 | 0.8656530 | 0.23066 | NA | NA |
| CD274 | regorafenib | 0.2309083 | 0.8656530 | 0.23091 | NA | NA |
| NPM1 | fulvestrant | 0.2309231 | 0.8656530 | 0.23092 | NA | NA |
| EZH2 | olaparib | 0.2316089 | 0.8659530 | 0.23161 | NA | NA |
| MGMT | dasatinib | 0.2320758 | 0.8659530 | 0.23208 | NA | NA |
| NRAS | cabozantinib | 0.2323251 | 0.8659530 | 0.23233 | NA | NA |
| FLT3 | ibrutinib | 0.2324658 | 0.8659530 | 0.23247 | NA | NA |
| DDIT3 | erlotinib | 0.2324701 | 0.8659530 | 0.23247 | NA | NA |
| ATM | neratinib | 0.2324855 | 0.8659530 | 0.23249 | NA | NA |
| IDH1 | dabrafenib | 0.2330706 | 0.8664682 | 0.23307 | NA | NA |
| AKT3 | regorafenib | 0.2333180 | 0.8664682 | 0.23332 | NA | NA |
| PTPN11 | neratinib | 0.2334787 | 0.8664682 | 0.23348 | NA | NA |
| PAX8 | pazopanib | 0.2336994 | 0.8664682 | 0.23370 | NA | NA |
| NT5C2 | gefitinib | 0.2340763 | 0.8664682 | 0.23408 | NA | NA |
| PHF6 | vemurafenib | 0.2342709 | 0.8664682 | 0.23427 | NA | NA |
| ROS1 | fulvestrant | 0.2343543 | 0.8664682 | 0.23435 | NA | NA |
| DNAJB1 | imatinib | 0.2355069 | 0.8667267 | 0.23551 | NA | NA |
| BCORL1 | vandetanib | 0.2356221 | 0.8667267 | 0.23562 | NA | NA |
| TPMT | vandetanib | 0.2358167 | 0.8667267 | 0.23582 | NA | NA |
| CDK4 | afatinib | 0.2359976 | 0.8667267 | 0.23600 | NA | NA |
| FLCN | ibrutinib | 0.2366080 | 0.8667267 | 0.23661 | NA | NA |
| SETBP1 | selumetinib | 0.2369905 | 0.8667267 | 0.23699 | NA | NA |
| GNA11 | azd | 0.2372309 | 0.8667267 | 0.23723 | NA | NA |
| BTK | belinostat | 0.2375233 | 0.8667267 | 0.23752 | NA | NA |
| MPL | erlotinib | 0.2375887 | 0.8667267 | 0.23759 | NA | NA |
| EED | vandetanib | 0.2376284 | 0.8667267 | 0.23763 | NA | NA |
| CDC73 | fulvestrant | 0.2377735 | 0.8667267 | 0.23777 | NA | NA |
| PHF6 | fluorouracil | 0.2378370 | 0.8667267 | 0.23784 | NA | NA |
| CSF3R | pazopanib | 0.2379733 | 0.8667267 | 0.23797 | NA | NA |
| DPYD | gefitinib | 0.2382705 | 0.8667267 | 0.23827 | NA | NA |
| FBXW7 | vemurafenib | 0.2383796 | 0.8667267 | 0.23838 | NA | NA |
| RET | crizotinib | 0.2389903 | 0.8667267 | 0.23899 | NA | NA |
| CRLF2 | imatinib | 0.2390427 | 0.8667267 | 0.23904 | NA | NA |
| CBLB | regorafenib | 0.2395929 | 0.8667267 | 0.23959 | NA | NA |
| MGMT | lapatinib | 0.2397677 | 0.8667267 | 0.23977 | NA | NA |
| CTLA4 | fluorouracil | 0.2402767 | 0.8667267 | 0.24028 | NA | NA |
| JAK3 | dasatinib | 0.2402918 | 0.8667267 | 0.24029 | NA | NA |
| ROS1 | trametinib | 0.2403793 | 0.8667267 | 0.24038 | NA | NA |
| IKZF1 | cyclophosphamide | 0.2404186 | 0.8667267 | 0.24042 | NA | NA |
| MYD88 | dabrafenib | 0.2408578 | 0.8667267 | 0.24086 | NA | NA |
| ZRSR2 | regorafenib | 0.2413351 | 0.8667267 | 0.24134 | NA | NA |
| SMC1A | vandetanib | 0.2415598 | 0.8667267 | 0.24156 | NA | NA |
| MDM2 | ruxolitinib | 0.2416067 | 0.8667267 | 0.24161 | NA | NA |
| CRLF2 | azd | 0.2416519 | 0.8667267 | 0.24165 | NA | NA |
| AKT3 | ibrutinib | 0.2417159 | 0.8667267 | 0.24172 | NA | NA |
| HRAS | afatinib | 0.2422902 | 0.8667267 | 0.24229 | NA | NA |
| TET2 | lapatinib | 0.2425768 | 0.8667267 | 0.24258 | NA | NA |
| IDH1 | afatinib | 0.2427725 | 0.8667267 | 0.24277 | NA | NA |
| ATM | regorafenib | 0.2428204 | 0.8667267 | 0.24282 | NA | NA |
| FGFR2 | belinostat | 0.2428319 | 0.8667267 | 0.24283 | NA | NA |
| AKT1 | lapatinib | 0.2447114 | 0.8674143 | 0.24471 | NA | NA |
| GATA2 | nilotinib | 0.2450251 | 0.8674143 | 0.24503 | NA | NA |
| CRLF2 | selumetinib | 0.2452080 | 0.8674143 | 0.24521 | NA | NA |
| CDK6 | sunitinib | 0.2452747 | 0.8674143 | 0.24527 | NA | NA |
| SMO | imatinib | 0.2453198 | 0.8674143 | 0.24532 | NA | NA |
| CSF3R | vemurafenib | 0.2456264 | 0.8674143 | 0.24563 | NA | NA |
| BTK | imatinib | 0.2456728 | 0.8674143 | 0.24567 | NA | NA |
| CREBBP | fulvestrant | 0.2457193 | 0.8674143 | 0.24572 | NA | NA |
| GATA1 | lapatinib | 0.2459512 | 0.8674143 | 0.24595 | NA | NA |
| PML | nilotinib | 0.2462058 | 0.8674143 | 0.24621 | NA | NA |
| KIT | crizotinib | 0.2466017 | 0.8674143 | 0.24660 | NA | NA |
| PDGFB | pazopanib | 0.2466642 | 0.8674143 | 0.24666 | NA | NA |
| RET | neratinib | 0.2474878 | 0.8674143 | 0.24749 | NA | NA |
| PDGFB | azd | 0.2475165 | 0.8674143 | 0.24752 | NA | NA |
| GNB1 | cabozantinib | 0.2476203 | 0.8674143 | 0.24762 | NA | NA |
| MGMT | vemurafenib | 0.2488404 | 0.8674143 | 0.24884 | NA | NA |
| CRLF2 | vandetanib | 0.2489356 | 0.8674143 | 0.24894 | NA | NA |
| GNB1 | belinostat | 0.2491958 | 0.8674143 | 0.24920 | NA | NA |
| MGMT | gefitinib | 0.2498351 | 0.8674143 | 0.24984 | NA | NA |
| CALR | olaparib | 0.2507276 | 0.8674143 | 0.25073 | NA | NA |
| MET | olaparib | 0.2511607 | 0.8674143 | 0.25116 | NA | NA |
| MDM2 | olaparib | 0.2517161 | 0.8674143 | 0.25172 | NA | NA |
| G6PD | sunitinib | 0.2518013 | 0.8674143 | 0.25180 | NA | NA |
| EGFR | afatinib | 0.2518397 | 0.8674143 | 0.25184 | NA | NA |
| TPMT | trametinib | 0.2520717 | 0.8674143 | 0.25207 | NA | NA |
| SETBP1 | dasatinib | 0.2521967 | 0.8674143 | 0.25220 | NA | NA |
| STAG2 | selumetinib | 0.2523100 | 0.8674143 | 0.25231 | NA | NA |
| EGF | vemurafenib | 0.2527242 | 0.8674143 | 0.25272 | NA | NA |
| CXCR4 | vandetanib | 0.2528544 | 0.8674143 | 0.25285 | NA | NA |
| JAK2 | cyclophosphamide | 0.2532387 | 0.8674143 | 0.25324 | NA | NA |
| SH2B3 | belinostat | 0.2533078 | 0.8674143 | 0.25331 | NA | NA |
| PTEN | olaparib | 0.2533258 | 0.8674143 | 0.25333 | NA | NA |
| CTNNB1 | dasatinib | 0.2535051 | 0.8674143 | 0.25351 | NA | NA |
| AKT2 | fluorouracil | 0.2539708 | 0.8674143 | 0.25397 | NA | NA |
| GNAQ | neratinib | 0.2542162 | 0.8674143 | 0.25422 | NA | NA |
| HRAS | trametinib | 0.2542381 | 0.8674143 | 0.25424 | NA | NA |
| DNAJB1 | fulvestrant | 0.2543262 | 0.8674143 | 0.25433 | NA | NA |
| ATM | vandetanib | 0.2544104 | 0.8674143 | 0.25441 | NA | NA |
| GNA11 | crizotinib | 0.2550325 | 0.8674143 | 0.25503 | NA | NA |
| TSC2 | cyclophosphamide | 0.2553250 | 0.8674143 | 0.25533 | NA | NA |
| TP53 | vemurafenib | 0.2553975 | 0.8674143 | 0.25540 | NA | NA |
| SETBP1 | erlotinib | 0.2557903 | 0.8674143 | 0.25579 | NA | NA |
| RAD21 | selumetinib | 0.2558348 | 0.8674143 | 0.25583 | NA | NA |
| RAD21 | ruxolitinib | 0.2560520 | 0.8674143 | 0.25605 | NA | NA |
| CBLB | lapatinib | 0.2563815 | 0.8674143 | 0.25638 | NA | NA |
| SMO | dabrafenib | 0.2563832 | 0.8674143 | 0.25638 | NA | NA |
| ASXL1 | neratinib | 0.2564350 | 0.8674143 | 0.25644 | NA | NA |
| CDK6 | temozolomide | 0.2564922 | 0.8674143 | 0.25649 | NA | NA |
| GATA3 | cyclophosphamide | 0.2567670 | 0.8674143 | 0.25677 | NA | NA |
| RAD21 | temozolomide | 0.2568042 | 0.8674143 | 0.25680 | NA | NA |
| MPL | fluorouracil | 0.2570595 | 0.8674143 | 0.25706 | NA | NA |
| UGT1A1 | regorafenib | 0.2573217 | 0.8674143 | 0.25732 | NA | NA |
| AKT2 | selumetinib | 0.2575985 | 0.8674143 | 0.25760 | NA | NA |
| CRLF2 | ruxolitinib | 0.2576407 | 0.8674143 | 0.25764 | NA | NA |
| MGMT | ruxolitinib | 0.2579077 | 0.8674143 | 0.25791 | NA | NA |
| NPM1 | ibrutinib | 0.2580132 | 0.8674143 | 0.25801 | NA | NA |
| CDK6 | regorafenib | 0.2580522 | 0.8674143 | 0.25805 | NA | NA |
| CD274 | vandetanib | 0.2581045 | 0.8674143 | 0.25810 | NA | NA |
| CALR | azd | 0.2581482 | 0.8674143 | 0.25815 | NA | NA |
| VHL | selumetinib | 0.2582785 | 0.8674143 | 0.25828 | NA | NA |
| PDGFRB | ibrutinib | 0.2584041 | 0.8674143 | 0.25840 | NA | NA |
| SETD2 | fulvestrant | 0.2588051 | 0.8674143 | 0.25881 | NA | NA |
| TPMT | pazopanib | 0.2589317 | 0.8674143 | 0.25893 | NA | NA |
| CD79B | belinostat | 0.2591552 | 0.8674143 | 0.25916 | NA | NA |
| TET2 | sunitinib | 0.2597084 | 0.8674143 | 0.25971 | NA | NA |
| FANCL | belinostat | 0.2597690 | 0.8674143 | 0.25977 | NA | NA |
| PAX5 | afatinib | 0.2600146 | 0.8674143 | 0.26001 | NA | NA |
| PRPF8 | erlotinib | 0.2604212 | 0.8674143 | 0.26042 | NA | NA |
| PTEN | azd | 0.2607677 | 0.8674143 | 0.26077 | NA | NA |
| GATA2 | selumetinib | 0.2608859 | 0.8674143 | 0.26089 | NA | NA |
| GNB1 | dasatinib | 0.2610861 | 0.8674143 | 0.26109 | NA | NA |
| JAK1 | sunitinib | 0.2612506 | 0.8674143 | 0.26125 | NA | NA |
| KMT2A | crizotinib | 0.2612591 | 0.8674143 | 0.26126 | NA | NA |
| SMC3 | dabrafenib | 0.2613379 | 0.8674143 | 0.26134 | NA | NA |
| AKT1 | olaparib | 0.2619009 | 0.8675957 | 0.26190 | NA | NA |
| PAX5 | fluorouracil | 0.2620065 | 0.8675957 | 0.26201 | NA | NA |
| WHSC1 | dabrafenib | 0.2624760 | 0.8675957 | 0.26248 | NA | NA |
| MAP2K2 | imatinib | 0.2628054 | 0.8675957 | 0.26281 | NA | NA |
| CSF3R | crizotinib | 0.2629812 | 0.8675957 | 0.26298 | NA | NA |
| IDH2 | lapatinib | 0.2631941 | 0.8675957 | 0.26319 | NA | NA |
| PML | olaparib | 0.2632816 | 0.8675957 | 0.26328 | NA | NA |
| SF1 | crizotinib | 0.2639172 | 0.8675957 | 0.26392 | NA | NA |
| MAP2K1 | azd | 0.2639379 | 0.8675957 | 0.26394 | NA | NA |
| ETV6 | fluorouracil | 0.2643094 | 0.8675957 | 0.26431 | NA | NA |
| MET | pazopanib | 0.2643242 | 0.8675957 | 0.26432 | NA | NA |
| ZRSR2 | nilotinib | 0.2643630 | 0.8675957 | 0.26436 | NA | NA |
| CREBBP | ruxolitinib | 0.2647155 | 0.8679226 | 0.26472 | NA | NA |
| MYCN | cyclophosphamide | 0.2649578 | 0.8679226 | 0.26496 | NA | NA |
| SMC1A | afatinib | 0.2653342 | 0.8683439 | 0.26533 | NA | NA |
| AKT3 | olaparib | 0.2660523 | 0.8688368 | 0.26605 | NA | NA |
| SMC1A | erlotinib | 0.2661647 | 0.8688368 | 0.26616 | NA | NA |
| GNAQ | crizotinib | 0.2662285 | 0.8688368 | 0.26623 | NA | NA |
| TSC2 | azd | 0.2666255 | 0.8693230 | 0.26663 | NA | NA |
| MPL | dasatinib | 0.2681902 | 0.8736121 | 0.26819 | NA | NA |
| TSC1 | dasatinib | 0.2684477 | 0.8736390 | 0.26845 | NA | NA |
| DDIT3 | lapatinib | 0.2688137 | 0.8740185 | 0.26881 | NA | NA |
| NOTCH2 | lapatinib | 0.2694024 | 0.8751207 | 0.26940 | NA | NA |
| SSX1 | cabozantinib | 0.2698860 | 0.8758802 | 0.26989 | NA | NA |
| MYD88 | cabozantinib | 0.2705198 | 0.8762072 | 0.27052 | NA | NA |
| IDH1 | neratinib | 0.2706290 | 0.8762072 | 0.27063 | NA | NA |
| EZH2 | nilotinib | 0.2708587 | 0.8762072 | 0.27086 | NA | NA |
| AKT1 | gefitinib | 0.2710276 | 0.8762072 | 0.27103 | NA | NA |
| CDC73 | sunitinib | 0.2712626 | 0.8762072 | 0.27126 | NA | NA |
| WT1 | lapatinib | 0.2714867 | 0.8762072 | 0.27149 | NA | NA |
| CDK6 | azd | 0.2719821 | 0.8769984 | 0.27198 | NA | NA |
| MYD88 | lapatinib | 0.2727428 | 0.8782850 | 0.27274 | NA | NA |
| JAK2 | fulvestrant | 0.2731170 | 0.8782850 | 0.27312 | NA | NA |
| DNAJB1 | fluorouracil | 0.2734351 | 0.8782850 | 0.27344 | NA | NA |
| MYCN | erlotinib | 0.2736975 | 0.8782850 | 0.27370 | NA | NA |
| CYP19A1 | lapatinib | 0.2738891 | 0.8782850 | 0.27389 | NA | NA |
| ERBB2 | gefitinib | 0.2741193 | 0.8782850 | 0.27412 | NA | NA |
| NOTCH1 | vemurafenib | 0.2741352 | 0.8782850 | 0.27414 | NA | NA |
| NRAS | vemurafenib | 0.2747336 | 0.8792858 | 0.27473 | NA | NA |
| PDGFRA | selumetinib | 0.2749493 | 0.8792858 | 0.27495 | NA | NA |
| FANCL | fulvestrant | 0.2754040 | 0.8795956 | 0.27540 | NA | NA |
| RAD21 | pazopanib | 0.2756366 | 0.8795956 | 0.27564 | NA | NA |
| KMT2A | imatinib | 0.2757990 | 0.8795956 | 0.27580 | NA | NA |
| FGFR1 | regorafenib | 0.2760560 | 0.8796148 | 0.27606 | NA | NA |
| GNAQ | erlotinib | 0.2763653 | 0.8797903 | 0.27637 | NA | NA |
| KRAS | fulvestrant | 0.2766131 | 0.8797903 | 0.27661 | NA | NA |
| TSC1 | imatinib | 0.2772743 | 0.8803274 | 0.27727 | NA | NA |
| FGFR2 | fluorouracil | 0.2774309 | 0.8803274 | 0.27743 | NA | NA |
| MGMT | trametinib | 0.2783193 | 0.8803274 | 0.27832 | NA | NA |
| NRAS | neratinib | 0.2783736 | 0.8803274 | 0.27837 | NA | NA |
| ALK | imatinib | 0.2787671 | 0.8803274 | 0.27877 | NA | NA |
| MGMT | fulvestrant | 0.2788073 | 0.8803274 | 0.27881 | NA | NA |
| AKT1 | ibrutinib | 0.2790808 | 0.8803274 | 0.27908 | NA | NA |
| ROS1 | sunitinib | 0.2791187 | 0.8803274 | 0.27912 | NA | NA |
| CBL | nilotinib | 0.2792044 | 0.8803274 | 0.27920 | NA | NA |
| FLT3 | dabrafenib | 0.2794287 | 0.8803274 | 0.27943 | NA | NA |
| NOTCH2 | gefitinib | 0.2795448 | 0.8803274 | 0.27954 | NA | NA |
| ABL1 | fulvestrant | 0.2803031 | 0.8809381 | 0.28030 | NA | NA |
| CEBPA | temozolomide | 0.2806538 | 0.8809381 | 0.28065 | NA | NA |
| SETBP1 | olaparib | 0.2806725 | 0.8809381 | 0.28067 | NA | NA |
| SF1 | sunitinib | 0.2809586 | 0.8809381 | 0.28096 | NA | NA |
| STAT3 | cabozantinib | 0.2811915 | 0.8809381 | 0.28119 | NA | NA |
| U2AF1 | dabrafenib | 0.2819991 | 0.8809381 | 0.28200 | NA | NA |
| TSC2 | sunitinib | 0.2822305 | 0.8809381 | 0.28223 | NA | NA |
| AKT3 | erlotinib | 0.2822462 | 0.8809381 | 0.28225 | NA | NA |
| CXCR4 | ibrutinib | 0.2825615 | 0.8809381 | 0.28256 | NA | NA |
| ERBB2 | trametinib | 0.2825628 | 0.8809381 | 0.28256 | NA | NA |
| ATM | ibrutinib | 0.2827345 | 0.8809381 | 0.28273 | NA | NA |
| AKT2 | crizotinib | 0.2831390 | 0.8809381 | 0.28314 | NA | NA |
| CYP19A1 | fulvestrant | 0.2831609 | 0.8809381 | 0.28316 | NA | NA |
| MDM2 | cyclophosphamide | 0.2833971 | 0.8809381 | 0.28340 | NA | NA |
| MPL | azd | 0.2837117 | 0.8809381 | 0.28371 | NA | NA |
| BRCA1 | lapatinib | 0.2837601 | 0.8809381 | 0.28376 | NA | NA |
| CREBBP | belinostat | 0.2843252 | 0.8816267 | 0.28433 | NA | NA |
| AKT3 | temozolomide | 0.2849774 | 0.8816267 | 0.28498 | NA | NA |
| EGFR | vandetanib | 0.2853916 | 0.8816267 | 0.28539 | NA | NA |
| PTCH1 | dasatinib | 0.2856356 | 0.8816267 | 0.28564 | NA | NA |
| FLCN | erlotinib | 0.2860245 | 0.8816267 | 0.28602 | NA | NA |
| TP53 | dasatinib | 0.2863574 | 0.8816267 | 0.28636 | NA | NA |
| SMC1A | trametinib | 0.2863916 | 0.8816267 | 0.28639 | NA | NA |
| CTLA4 | cyclophosphamide | 0.2868338 | 0.8816267 | 0.28683 | NA | NA |
| CTCF | trametinib | 0.2869070 | 0.8816267 | 0.28691 | NA | NA |
| ERBB3 | sunitinib | 0.2869264 | 0.8816267 | 0.28693 | NA | NA |
| CBLB | nilotinib | 0.2871786 | 0.8816267 | 0.28718 | NA | NA |
| PTPN11 | ruxolitinib | 0.2873910 | 0.8816267 | 0.28739 | NA | NA |
| CRLF2 | vemurafenib | 0.2877686 | 0.8816267 | 0.28777 | NA | NA |
| ESR1 | olaparib | 0.2881802 | 0.8816267 | 0.28818 | NA | NA |
| CTCF | vandetanib | 0.2881981 | 0.8816267 | 0.28820 | NA | NA |
| PIGA | gefitinib | 0.2884608 | 0.8816267 | 0.28846 | NA | NA |
| NOTCH1 | selumetinib | 0.2885067 | 0.8816267 | 0.28851 | NA | NA |
| KMT2A | gefitinib | 0.2885492 | 0.8816267 | 0.28855 | NA | NA |
| U2AF1 | belinostat | 0.2889914 | 0.8816267 | 0.28899 | NA | NA |
| TPMT | fluorouracil | 0.2892300 | 0.8816267 | 0.28923 | NA | NA |
| CXCR4 | dabrafenib | 0.2893574 | 0.8816267 | 0.28936 | NA | NA |
| MET | regorafenib | 0.2896133 | 0.8816267 | 0.28961 | NA | NA |
| GATA3 | afatinib | 0.2898703 | 0.8816267 | 0.28987 | NA | NA |
| EML4 | selumetinib | 0.2900187 | 0.8816267 | 0.29002 | NA | NA |
| PDGFRB | neratinib | 0.2911880 | 0.8821411 | 0.29119 | NA | NA |
| ETV6 | cabozantinib | 0.2912697 | 0.8821411 | 0.29127 | NA | NA |
| CBLB | erlotinib | 0.2916741 | 0.8821411 | 0.29167 | NA | NA |
| PTPN11 | vemurafenib | 0.2920187 | 0.8821411 | 0.29202 | NA | NA |
| CTLA4 | imatinib | 0.2920684 | 0.8821411 | 0.29207 | NA | NA |
| CTCF | regorafenib | 0.2923352 | 0.8821411 | 0.29234 | NA | NA |
| TET2 | azd | 0.2924355 | 0.8821411 | 0.29244 | NA | NA |
| FBXW7 | azd | 0.2927105 | 0.8821411 | 0.29271 | NA | NA |
| MDM2 | regorafenib | 0.2932049 | 0.8821411 | 0.29320 | NA | NA |
| GATA3 | ruxolitinib | 0.2934338 | 0.8821411 | 0.29343 | NA | NA |
| IKZF1 | temozolomide | 0.2934346 | 0.8821411 | 0.29343 | NA | NA |
| FGFR2 | cyclophosphamide | 0.2935343 | 0.8821411 | 0.29353 | NA | NA |
| IDH2 | vandetanib | 0.2935755 | 0.8821411 | 0.29358 | NA | NA |
| ASXL1 | fluorouracil | 0.2939734 | 0.8821411 | 0.29397 | NA | NA |
| IL7R | afatinib | 0.2939743 | 0.8821411 | 0.29397 | NA | NA |
| GATA2 | vemurafenib | 0.2950040 | 0.8821411 | 0.29500 | NA | NA |
| SF1 | neratinib | 0.2954882 | 0.8821411 | 0.29549 | NA | NA |
| SMC1A | fluorouracil | 0.2955037 | 0.8821411 | 0.29550 | NA | NA |
| ERBB4 | fluorouracil | 0.2955055 | 0.8821411 | 0.29551 | NA | NA |
| PRPF40B | gefitinib | 0.2961110 | 0.8821411 | 0.29611 | NA | NA |
| ERBB2 | imatinib | 0.2961755 | 0.8821411 | 0.29618 | NA | NA |
| DDIT3 | temozolomide | 0.2963246 | 0.8821411 | 0.29632 | NA | NA |
| SMO | cyclophosphamide | 0.2963860 | 0.8821411 | 0.29639 | NA | NA |
| AKT2 | dasatinib | 0.2963964 | 0.8821411 | 0.29640 | NA | NA |
| CD79B | trametinib | 0.2968588 | 0.8821411 | 0.29686 | NA | NA |
| FANCL | temozolomide | 0.2969751 | 0.8821411 | 0.29698 | NA | NA |
| TET2 | erlotinib | 0.2973793 | 0.8821411 | 0.29738 | NA | NA |
| NPM1 | azd | 0.2976666 | 0.8821411 | 0.29767 | NA | NA |
| DPYD | belinostat | 0.2978744 | 0.8821411 | 0.29787 | NA | NA |
| RUNX1 | azd | 0.2978920 | 0.8821411 | 0.29789 | NA | NA |
| UGT1A1 | ruxolitinib | 0.2979995 | 0.8821411 | 0.29800 | NA | NA |
| PRPF40B | ibrutinib | 0.2982417 | 0.8821411 | 0.29824 | NA | NA |
| AKT2 | olaparib | 0.2991931 | 0.8828175 | 0.29919 | NA | NA |
| TSC2 | dasatinib | 0.2997123 | 0.8828175 | 0.29971 | NA | NA |
| MGMT | nilotinib | 0.3000538 | 0.8828175 | 0.30005 | NA | NA |
| CSF3R | lapatinib | 0.3001644 | 0.8828175 | 0.30016 | NA | NA |
| EED | pazopanib | 0.3002423 | 0.8828175 | 0.30024 | NA | NA |
| FGFR3 | regorafenib | 0.3005907 | 0.8828175 | 0.30059 | NA | NA |
| PRPF40B | ruxolitinib | 0.3008615 | 0.8828175 | 0.30086 | NA | NA |
| NT5C2 | dabrafenib | 0.3009126 | 0.8828175 | 0.30091 | NA | NA |
| NPM1 | cabozantinib | 0.3013980 | 0.8828175 | 0.30140 | NA | NA |
| MPL | afatinib | 0.3014431 | 0.8828175 | 0.30144 | NA | NA |
| CEBPA | azd | 0.3014960 | 0.8828175 | 0.30150 | NA | NA |
| ABL1 | crizotinib | 0.3022158 | 0.8828175 | 0.30222 | NA | NA |
| PTCH1 | azd | 0.3023110 | 0.8828175 | 0.30231 | NA | NA |
| ZRSR2 | lapatinib | 0.3028480 | 0.8828175 | 0.30285 | NA | NA |
| PRPF40B | fluorouracil | 0.3029401 | 0.8828175 | 0.30294 | NA | NA |
| ABL1 | cabozantinib | 0.3029475 | 0.8828175 | 0.30295 | NA | NA |
| RIT1 | temozolomide | 0.3038985 | 0.8828175 | 0.30390 | NA | NA |
| SETBP1 | afatinib | 0.3042461 | 0.8828175 | 0.30425 | NA | NA |
| CYP19A1 | olaparib | 0.3043830 | 0.8828175 | 0.30438 | NA | NA |
| ESR1 | gefitinib | 0.3045810 | 0.8828175 | 0.30458 | NA | NA |
| CTLA4 | fulvestrant | 0.3049799 | 0.8828175 | 0.30498 | NA | NA |
| U2AF1 | pazopanib | 0.3050361 | 0.8828175 | 0.30504 | NA | NA |
| PDGFB | neratinib | 0.3051659 | 0.8828175 | 0.30517 | NA | NA |
| GATA3 | erlotinib | 0.3053780 | 0.8828175 | 0.30538 | NA | NA |
| NCOA2 | nilotinib | 0.3062132 | 0.8828175 | 0.30621 | NA | NA |
| ATM | belinostat | 0.3062787 | 0.8828175 | 0.30628 | NA | NA |
| ALK | vemurafenib | 0.3064787 | 0.8828175 | 0.30648 | NA | NA |
| AKT3 | gefitinib | 0.3065438 | 0.8828175 | 0.30654 | NA | NA |
| MPL | cyclophosphamide | 0.3067703 | 0.8828175 | 0.30677 | NA | NA |
| EED | gefitinib | 0.3071090 | 0.8828175 | 0.30711 | NA | NA |
| PDGFRA | vandetanib | 0.3074459 | 0.8828175 | 0.30745 | NA | NA |
| FGFR1 | fluorouracil | 0.3077045 | 0.8828175 | 0.30770 | NA | NA |
| AKT1 | afatinib | 0.3079994 | 0.8828175 | 0.30800 | NA | NA |
| CRLF2 | lapatinib | 0.3083616 | 0.8828175 | 0.30836 | NA | NA |
| BRAF | belinostat | 0.3085030 | 0.8828175 | 0.30850 | NA | NA |
| BCORL1 | azd | 0.3088967 | 0.8828175 | 0.30890 | NA | NA |
| ETV6 | cyclophosphamide | 0.3091910 | 0.8828175 | 0.30919 | NA | NA |
| TSC1 | selumetinib | 0.3094377 | 0.8828175 | 0.30944 | NA | NA |
| JAK1 | ibrutinib | 0.3097846 | 0.8828175 | 0.30978 | NA | NA |
| RAD21 | cyclophosphamide | 0.3098551 | 0.8828175 | 0.30986 | NA | NA |
| DNMT3A | imatinib | 0.3100619 | 0.8828175 | 0.31006 | NA | NA |
| IDH1 | trametinib | 0.3101846 | 0.8828175 | 0.31018 | NA | NA |
| BCORL1 | sunitinib | 0.3102331 | 0.8828175 | 0.31023 | NA | NA |
| TPMT | erlotinib | 0.3109754 | 0.8828175 | 0.31098 | NA | NA |
| ERBB4 | sunitinib | 0.3111662 | 0.8828175 | 0.31117 | NA | NA |
| AR | pazopanib | 0.3113639 | 0.8828175 | 0.31136 | NA | NA |
| GNAS | selumetinib | 0.3113969 | 0.8828175 | 0.31140 | NA | NA |
| PML | trametinib | 0.3122459 | 0.8828175 | 0.31225 | NA | NA |
| CREBBP | neratinib | 0.3125282 | 0.8828175 | 0.31253 | NA | NA |
| IDH1 | fluorouracil | 0.3134090 | 0.8828175 | 0.31341 | NA | NA |
| ATM | dabrafenib | 0.3134509 | 0.8828175 | 0.31345 | NA | NA |
| FGFR1 | neratinib | 0.3142733 | 0.8828175 | 0.31427 | NA | NA |
| NT5C2 | cabozantinib | 0.3143224 | 0.8828175 | 0.31432 | NA | NA |
| NRAS | temozolomide | 0.3147868 | 0.8828175 | 0.31479 | NA | NA |
| ALK | trametinib | 0.3149108 | 0.8828175 | 0.31491 | NA | NA |
| AKT2 | azd | 0.3150406 | 0.8828175 | 0.31504 | NA | NA |
| RET | dasatinib | 0.3153187 | 0.8828175 | 0.31532 | NA | NA |
| BCORL1 | ibrutinib | 0.3155659 | 0.8828175 | 0.31557 | NA | NA |
| AKT3 | afatinib | 0.3156911 | 0.8828175 | 0.31569 | NA | NA |
| HRAS | cyclophosphamide | 0.3160466 | 0.8828175 | 0.31605 | NA | NA |
| UGT1A1 | imatinib | 0.3163786 | 0.8828175 | 0.31638 | NA | NA |
| CDKN2A | fluorouracil | 0.3166316 | 0.8828175 | 0.31663 | NA | NA |
| BTK | dasatinib | 0.3168831 | 0.8828175 | 0.31688 | NA | NA |
| MYD88 | gefitinib | 0.3170349 | 0.8828175 | 0.31703 | NA | NA |
| EGFR | olaparib | 0.3170528 | 0.8828175 | 0.31705 | NA | NA |
| SMC1A | ibrutinib | 0.3176370 | 0.8828175 | 0.31764 | NA | NA |
| MYD88 | ibrutinib | 0.3177454 | 0.8828175 | 0.31775 | NA | NA |
| AKT3 | lapatinib | 0.3177864 | 0.8828175 | 0.31779 | NA | NA |
| CTLA4 | ruxolitinib | 0.3178868 | 0.8828175 | 0.31789 | NA | NA |
| CBL | sunitinib | 0.3182987 | 0.8828175 | 0.31830 | NA | NA |
| AKT3 | selumetinib | 0.3182989 | 0.8828175 | 0.31830 | NA | NA |
| CREBBP | regorafenib | 0.3183678 | 0.8828175 | 0.31837 | NA | NA |
| PRPF40B | regorafenib | 0.3184834 | 0.8828175 | 0.31848 | NA | NA |
| VHL | vemurafenib | 0.3188942 | 0.8828175 | 0.31889 | NA | NA |
| FLT3 | pazopanib | 0.3190784 | 0.8828175 | 0.31908 | NA | NA |
| GATA3 | dasatinib | 0.3193230 | 0.8828175 | 0.31932 | NA | NA |
| FGFR2 | lapatinib | 0.3194959 | 0.8828175 | 0.31950 | NA | NA |
| GNA11 | cyclophosphamide | 0.3198950 | 0.8828175 | 0.31989 | NA | NA |
| ROS1 | temozolomide | 0.3206533 | 0.8828175 | 0.32065 | NA | NA |
| NT5C2 | azd | 0.3207060 | 0.8828175 | 0.32071 | NA | NA |
| EGF | ruxolitinib | 0.3211726 | 0.8828175 | 0.32117 | NA | NA |
| PTPN11 | fluorouracil | 0.3212658 | 0.8828175 | 0.32127 | NA | NA |
| SF3B1 | olaparib | 0.3213662 | 0.8828175 | 0.32137 | NA | NA |
| CALR | vandetanib | 0.3215620 | 0.8828175 | 0.32156 | NA | NA |
| SF3B1 | azd | 0.3217139 | 0.8828175 | 0.32171 | NA | NA |
| CTCF | azd | 0.3221524 | 0.8828175 | 0.32215 | NA | NA |
| JAK1 | nilotinib | 0.3226560 | 0.8828175 | 0.32266 | NA | NA |
| PRPF40B | dabrafenib | 0.3227384 | 0.8828175 | 0.32274 | NA | NA |
| TSC2 | nilotinib | 0.3227612 | 0.8828175 | 0.32276 | NA | NA |
| CREBBP | crizotinib | 0.3231958 | 0.8828175 | 0.32320 | NA | NA |
| CXCR4 | afatinib | 0.3233187 | 0.8828175 | 0.32332 | NA | NA |
| BRCA1 | temozolomide | 0.3234468 | 0.8828175 | 0.32345 | NA | NA |
| CTLA4 | azd | 0.3234500 | 0.8828175 | 0.32345 | NA | NA |
| RIT1 | pazopanib | 0.3234541 | 0.8828175 | 0.32345 | NA | NA |
| IL7R | regorafenib | 0.3236656 | 0.8828175 | 0.32367 | NA | NA |
| GNB1 | selumetinib | 0.3236710 | 0.8828175 | 0.32367 | NA | NA |
| ASXL1 | vemurafenib | 0.3239676 | 0.8828175 | 0.32397 | NA | NA |
| PAX5 | azd | 0.3240109 | 0.8828175 | 0.32401 | NA | NA |
| PDGFRA | regorafenib | 0.3247031 | 0.8828175 | 0.32470 | NA | NA |
| SETBP1 | vemurafenib | 0.3247472 | 0.8828175 | 0.32475 | NA | NA |
| G6PD | cabozantinib | 0.3251186 | 0.8828175 | 0.32512 | NA | NA |
| ALK | olaparib | 0.3253829 | 0.8828175 | 0.32538 | NA | NA |
| CD79B | fluorouracil | 0.3253899 | 0.8828175 | 0.32539 | NA | NA |
| PHF6 | pazopanib | 0.3255305 | 0.8828175 | 0.32553 | NA | NA |
| IDH2 | dabrafenib | 0.3256308 | 0.8828175 | 0.32563 | NA | NA |
| RIT1 | dabrafenib | 0.3256308 | 0.8828175 | 0.32563 | NA | NA |
| WHSC1 | erlotinib | 0.3258074 | 0.8828175 | 0.32581 | NA | NA |
| CSF3R | vandetanib | 0.3260300 | 0.8828175 | 0.32603 | NA | NA |
| BCOR | imatinib | 0.3260497 | 0.8828175 | 0.32605 | NA | NA |
| PHF6 | imatinib | 0.3261765 | 0.8828175 | 0.32618 | NA | NA |
| KMT2A | sunitinib | 0.3266300 | 0.8833627 | 0.32663 | NA | NA |
| PDGFRB | ruxolitinib | 0.3271325 | 0.8837318 | 0.32713 | NA | NA |
| GNB1 | dabrafenib | 0.3273825 | 0.8837318 | 0.32738 | NA | NA |
| EED | ibrutinib | 0.3284269 | 0.8837318 | 0.32843 | NA | NA |
| PDGFB | imatinib | 0.3290742 | 0.8837318 | 0.32907 | NA | NA |
| AKT3 | fluorouracil | 0.3291512 | 0.8837318 | 0.32915 | NA | NA |
| BRCA1 | regorafenib | 0.3293828 | 0.8837318 | 0.32938 | NA | NA |
| ABL1 | fluorouracil | 0.3296373 | 0.8837318 | 0.32964 | NA | NA |
| UGT1A1 | ibrutinib | 0.3298241 | 0.8837318 | 0.32982 | NA | NA |
| ERBB3 | imatinib | 0.3301067 | 0.8837318 | 0.33011 | NA | NA |
| CSF3R | olaparib | 0.3303395 | 0.8837318 | 0.33034 | NA | NA |
| SF1 | dasatinib | 0.3304244 | 0.8837318 | 0.33042 | NA | NA |
| ESR1 | lapatinib | 0.3306838 | 0.8837318 | 0.33068 | NA | NA |
| TPMT | azd | 0.3307900 | 0.8837318 | 0.33079 | NA | NA |
| BCORL1 | nilotinib | 0.3309074 | 0.8837318 | 0.33091 | NA | NA |
| CALR | vemurafenib | 0.3310767 | 0.8837318 | 0.33108 | NA | NA |
| PIGA | dasatinib | 0.3312493 | 0.8837318 | 0.33125 | NA | NA |
| MET | lapatinib | 0.3313687 | 0.8837318 | 0.33137 | NA | NA |
| MAP2K1 | vemurafenib | 0.3317071 | 0.8837318 | 0.33171 | NA | NA |
| KIT | gefitinib | 0.3317245 | 0.8837318 | 0.33172 | NA | NA |
| PDCD1 | nilotinib | 0.3318322 | 0.8837318 | 0.33183 | NA | NA |
| MYD88 | afatinib | 0.3320613 | 0.8837318 | 0.33206 | NA | NA |
| MYCN | afatinib | 0.3331030 | 0.8847030 | 0.33310 | NA | NA |
| PDGFRA | fluorouracil | 0.3334048 | 0.8847030 | 0.33340 | NA | NA |
| AKT3 | belinostat | 0.3334805 | 0.8847030 | 0.33348 | NA | NA |
| CXCR4 | ruxolitinib | 0.3336917 | 0.8847030 | 0.33369 | NA | NA |
| IDH2 | neratinib | 0.3337619 | 0.8847030 | 0.33376 | NA | NA |
| NCOA2 | regorafenib | 0.3339495 | 0.8847030 | 0.33395 | NA | NA |
| SMC1A | imatinib | 0.3343171 | 0.8847030 | 0.33432 | NA | NA |
| PIK3CA | gefitinib | 0.3344455 | 0.8847030 | 0.33445 | NA | NA |
| JAK3 | erlotinib | 0.3348706 | 0.8851311 | 0.33487 | NA | NA |
| IKZF1 | lapatinib | 0.3351124 | 0.8851311 | 0.33511 | NA | NA |
| CEBPA | neratinib | 0.3356933 | 0.8859977 | 0.33569 | NA | NA |
| FLCN | afatinib | 0.3363242 | 0.8866217 | 0.33632 | NA | NA |
| GATA1 | fulvestrant | 0.3364356 | 0.8866217 | 0.33644 | NA | NA |
| SF1 | imatinib | 0.3371007 | 0.8868192 | 0.33710 | NA | NA |
| GNAQ | fulvestrant | 0.3372669 | 0.8868192 | 0.33727 | NA | NA |
| FLCN | cyclophosphamide | 0.3374113 | 0.8868192 | 0.33741 | NA | NA |
| CD274 | pazopanib | 0.3383606 | 0.8868192 | 0.33836 | NA | NA |
| GNAQ | afatinib | 0.3383818 | 0.8868192 | 0.33838 | NA | NA |
| MYD88 | azd | 0.3389331 | 0.8868192 | 0.33893 | NA | NA |
| RPL10 | selumetinib | 0.3389406 | 0.8868192 | 0.33894 | NA | NA |
| PML | imatinib | 0.3392370 | 0.8868192 | 0.33924 | NA | NA |
| XPO1 | fluorouracil | 0.3392677 | 0.8868192 | 0.33927 | NA | NA |
| CEBPA | selumetinib | 0.3394672 | 0.8868192 | 0.33947 | NA | NA |
| ERBB2 | selumetinib | 0.3397053 | 0.8868192 | 0.33971 | NA | NA |
| CSF3R | gefitinib | 0.3399769 | 0.8868192 | 0.33998 | NA | NA |
| CTNNB1 | afatinib | 0.3404043 | 0.8868192 | 0.34040 | NA | NA |
| PAX5 | ibrutinib | 0.3406093 | 0.8868192 | 0.34061 | NA | NA |
| GNB1 | ibrutinib | 0.3413260 | 0.8868192 | 0.34133 | NA | NA |
| SRSF2 | temozolomide | 0.3413326 | 0.8868192 | 0.34133 | NA | NA |
| RUNX1 | ruxolitinib | 0.3416103 | 0.8868192 | 0.34161 | NA | NA |
| SETD2 | imatinib | 0.3416838 | 0.8868192 | 0.34168 | NA | NA |
| STAT3 | selumetinib | 0.3417326 | 0.8868192 | 0.34173 | NA | NA |
| FGFR1 | crizotinib | 0.3420972 | 0.8868192 | 0.34210 | NA | NA |
| ABL1 | afatinib | 0.3423060 | 0.8868192 | 0.34231 | NA | NA |
| IKZF1 | vandetanib | 0.3423478 | 0.8868192 | 0.34235 | NA | NA |
| CDK6 | lapatinib | 0.3424403 | 0.8868192 | 0.34244 | NA | NA |
| KRAS | imatinib | 0.3425829 | 0.8868192 | 0.34258 | NA | NA |
| TSC1 | regorafenib | 0.3430949 | 0.8874891 | 0.34309 | NA | NA |
| TET2 | afatinib | 0.3433771 | 0.8875640 | 0.34338 | NA | NA |
| FGFR2 | temozolomide | 0.3437027 | 0.8877509 | 0.34370 | NA | NA |
| ZRSR2 | vandetanib | 0.3441069 | 0.8878923 | 0.34411 | NA | NA |
| CD274 | temozolomide | 0.3449841 | 0.8878923 | 0.34498 | NA | NA |
| ESR1 | nilotinib | 0.3452748 | 0.8878923 | 0.34527 | NA | NA |
| TET2 | selumetinib | 0.3454170 | 0.8878923 | 0.34542 | NA | NA |
| NPM1 | fluorouracil | 0.3455604 | 0.8878923 | 0.34556 | NA | NA |
| ETV6 | erlotinib | 0.3458953 | 0.8878923 | 0.34590 | NA | NA |
| ETV6 | ruxolitinib | 0.3459053 | 0.8878923 | 0.34591 | NA | NA |
| FGFR2 | trametinib | 0.3461649 | 0.8878923 | 0.34616 | NA | NA |
| CALR | regorafenib | 0.3462390 | 0.8878923 | 0.34624 | NA | NA |
| GNAQ | olaparib | 0.3462907 | 0.8878923 | 0.34629 | NA | NA |
| EZH2 | lapatinib | 0.3465800 | 0.8879847 | 0.34658 | NA | NA |
| BRAF | nilotinib | 0.3473234 | 0.8882411 | 0.34732 | NA | NA |
| GNAS | regorafenib | 0.3474147 | 0.8882411 | 0.34741 | NA | NA |
| FGFR1 | pazopanib | 0.3476889 | 0.8882411 | 0.34769 | NA | NA |
| PAX8 | trametinib | 0.3478909 | 0.8882411 | 0.34789 | NA | NA |
| ERBB3 | belinostat | 0.3479934 | 0.8882411 | 0.34799 | NA | NA |
| NOTCH2 | dasatinib | 0.3486982 | 0.8882411 | 0.34870 | NA | NA |
| PAX5 | fulvestrant | 0.3494676 | 0.8882411 | 0.34947 | NA | NA |
| IKZF1 | imatinib | 0.3495557 | 0.8882411 | 0.34956 | NA | NA |
| BCORL1 | dasatinib | 0.3496889 | 0.8882411 | 0.34969 | NA | NA |
| CD79B | selumetinib | 0.3497566 | 0.8882411 | 0.34976 | NA | NA |
| KMT2A | temozolomide | 0.3497716 | 0.8882411 | 0.34977 | NA | NA |
| IDH2 | cabozantinib | 0.3499020 | 0.8882411 | 0.34990 | NA | NA |
| CXCR4 | lapatinib | 0.3499746 | 0.8882411 | 0.34997 | NA | NA |
| NPM1 | neratinib | 0.3504438 | 0.8887883 | 0.35044 | NA | NA |
| TSC2 | afatinib | 0.3514315 | 0.8906489 | 0.35143 | NA | NA |
| NRAS | nilotinib | 0.3521881 | 0.8915494 | 0.35219 | NA | NA |
| KRAS | dasatinib | 0.3522956 | 0.8915494 | 0.35230 | NA | NA |
| BCOR | olaparib | 0.3535476 | 0.8936083 | 0.35355 | NA | NA |
| CSF3R | dasatinib | 0.3536190 | 0.8936083 | 0.35362 | NA | NA |
| GNAQ | fluorouracil | 0.3544828 | 0.8949123 | 0.35448 | NA | NA |
| RIT1 | selumetinib | 0.3552063 | 0.8949123 | 0.35521 | NA | NA |
| WT1 | vemurafenib | 0.3553105 | 0.8949123 | 0.35531 | NA | NA |
| DDIT3 | azd | 0.3561125 | 0.8949123 | 0.35611 | NA | NA |
| ERBB3 | cyclophosphamide | 0.3561490 | 0.8949123 | 0.35615 | NA | NA |
| RUNX1 | dasatinib | 0.3565982 | 0.8949123 | 0.35660 | NA | NA |
| STAG2 | nilotinib | 0.3568363 | 0.8949123 | 0.35684 | NA | NA |
| IDH2 | azd | 0.3568667 | 0.8949123 | 0.35687 | NA | NA |
| PDGFB | dasatinib | 0.3571989 | 0.8949123 | 0.35720 | NA | NA |
| WHSC1 | crizotinib | 0.3576979 | 0.8949123 | 0.35770 | NA | NA |
| NPM1 | dabrafenib | 0.3577714 | 0.8949123 | 0.35777 | NA | NA |
| MDM2 | pazopanib | 0.3578286 | 0.8949123 | 0.35783 | NA | NA |
| BRAF | fulvestrant | 0.3578334 | 0.8949123 | 0.35783 | NA | NA |
| STAT3 | pazopanib | 0.3579352 | 0.8949123 | 0.35794 | NA | NA |
| TP53 | belinostat | 0.3581327 | 0.8949123 | 0.35813 | NA | NA |
| JAK1 | olaparib | 0.3582202 | 0.8949123 | 0.35822 | NA | NA |
| ALK | gefitinib | 0.3595266 | 0.8975362 | 0.35953 | NA | NA |
| MAP2K1 | cyclophosphamide | 0.3601036 | 0.8983367 | 0.36010 | NA | NA |
| FLCN | belinostat | 0.3607791 | 0.8990832 | 0.36078 | NA | NA |
| NPM1 | temozolomide | 0.3616494 | 0.8990832 | 0.36165 | NA | NA |
| PDGFB | nilotinib | 0.3618609 | 0.8990832 | 0.36186 | NA | NA |
| PIK3CA | imatinib | 0.3621148 | 0.8990832 | 0.36211 | NA | NA |
| ATM | cabozantinib | 0.3621986 | 0.8990832 | 0.36220 | NA | NA |
| PRPF40B | selumetinib | 0.3625025 | 0.8990832 | 0.36250 | NA | NA |
| RPL10 | erlotinib | 0.3626129 | 0.8990832 | 0.36261 | NA | NA |
| UGT1A1 | temozolomide | 0.3627228 | 0.8990832 | 0.36272 | NA | NA |
| MET | dabrafenib | 0.3629609 | 0.8990832 | 0.36296 | NA | NA |
| PDGFRB | belinostat | 0.3636843 | 0.8990832 | 0.36368 | NA | NA |
| GNA11 | cabozantinib | 0.3638083 | 0.8990832 | 0.36381 | NA | NA |
| SF1 | regorafenib | 0.3638431 | 0.8990832 | 0.36384 | NA | NA |
| AKT2 | lapatinib | 0.3638501 | 0.8990832 | 0.36385 | NA | NA |
| CREBBP | afatinib | 0.3642004 | 0.8990832 | 0.36420 | NA | NA |
| WT1 | fulvestrant | 0.3644268 | 0.8990832 | 0.36443 | NA | NA |
| PDCD1 | sunitinib | 0.3647275 | 0.8990832 | 0.36473 | NA | NA |
| CREBBP | cyclophosphamide | 0.3647636 | 0.8990832 | 0.36476 | NA | NA |
| PDCD1 | belinostat | 0.3664396 | 0.9019409 | 0.36644 | NA | NA |
| ERBB3 | lapatinib | 0.3667711 | 0.9019409 | 0.36677 | NA | NA |
| FGFR3 | lapatinib | 0.3671204 | 0.9019409 | 0.36712 | NA | NA |
| PDCD1 | imatinib | 0.3671899 | 0.9019409 | 0.36719 | NA | NA |
| ZRSR2 | ibrutinib | 0.3673935 | 0.9019409 | 0.36739 | NA | NA |
| WHSC1 | lapatinib | 0.3678242 | 0.9019409 | 0.36782 | NA | NA |
| IDH2 | vemurafenib | 0.3678300 | 0.9019409 | 0.36783 | NA | NA |
| TPMT | regorafenib | 0.3679816 | 0.9019409 | 0.36798 | NA | NA |
| PIK3CA | lapatinib | 0.3687598 | 0.9032168 | 0.36876 | NA | NA |
| ERBB3 | azd | 0.3693126 | 0.9034689 | 0.36931 | NA | NA |
| GNAS | temozolomide | 0.3693783 | 0.9034689 | 0.36938 | NA | NA |
| FANCL | neratinib | 0.3697171 | 0.9036670 | 0.36972 | NA | NA |
| BTK | afatinib | 0.3703680 | 0.9040502 | 0.37037 | NA | NA |
| STAG2 | sunitinib | 0.3704770 | 0.9040502 | 0.37048 | NA | NA |
| DNAJB1 | temozolomide | 0.3708368 | 0.9040502 | 0.37084 | NA | NA |
| SF1 | fluorouracil | 0.3710817 | 0.9040502 | 0.37108 | NA | NA |
| SF3B1 | gefitinib | 0.3711635 | 0.9040502 | 0.37116 | NA | NA |
| MPL | nilotinib | 0.3715156 | 0.9042793 | 0.37152 | NA | NA |
| CEBPA | ibrutinib | 0.3723726 | 0.9051243 | 0.37237 | NA | NA |
| CDC73 | imatinib | 0.3724289 | 0.9051243 | 0.37243 | NA | NA |
| KMT2A | erlotinib | 0.3727940 | 0.9051243 | 0.37279 | NA | NA |
| ATM | afatinib | 0.3729788 | 0.9051243 | 0.37298 | NA | NA |
| PIGA | cyclophosphamide | 0.3735485 | 0.9051243 | 0.37355 | NA | NA |
| JAK2 | afatinib | 0.3737944 | 0.9051243 | 0.37379 | NA | NA |
| CDK4 | dasatinib | 0.3742145 | 0.9051243 | 0.37421 | NA | NA |
| FLT3 | temozolomide | 0.3743174 | 0.9051243 | 0.37432 | NA | NA |
| NOTCH2 | nilotinib | 0.3747480 | 0.9051243 | 0.37475 | NA | NA |
| SRSF2 | belinostat | 0.3748446 | 0.9051243 | 0.37484 | NA | NA |
| PAX8 | gefitinib | 0.3749321 | 0.9051243 | 0.37493 | NA | NA |
| IDH1 | azd | 0.3755131 | 0.9051243 | 0.37551 | NA | NA |
| CALR | imatinib | 0.3755417 | 0.9051243 | 0.37554 | NA | NA |
| FANCL | crizotinib | 0.3757263 | 0.9051243 | 0.37573 | NA | NA |
| CTNNB1 | lapatinib | 0.3760276 | 0.9051243 | 0.37603 | NA | NA |
| JAK1 | neratinib | 0.3764130 | 0.9051243 | 0.37641 | NA | NA |
| PHF6 | belinostat | 0.3764443 | 0.9051243 | 0.37644 | NA | NA |
| SRSF2 | ruxolitinib | 0.3766348 | 0.9051243 | 0.37663 | NA | NA |
| GNAQ | dabrafenib | 0.3767693 | 0.9051243 | 0.37677 | NA | NA |
| CDKN2A | cabozantinib | 0.3771227 | 0.9053528 | 0.37712 | NA | NA |
| ROS1 | cyclophosphamide | 0.3774686 | 0.9055630 | 0.37747 | NA | NA |
| ABL1 | ibrutinib | 0.3777841 | 0.9056999 | 0.37778 | NA | NA |
| PDGFRA | pazopanib | 0.3783240 | 0.9063744 | 0.37832 | NA | NA |
| CTCF | imatinib | 0.3786740 | 0.9065931 | 0.37867 | NA | NA |
| WT1 | fluorouracil | 0.3800925 | 0.9092610 | 0.38009 | NA | NA |
| GATA2 | fluorouracil | 0.3804329 | 0.9092610 | 0.38043 | NA | NA |
| EGFR | lapatinib | 0.3809004 | 0.9092610 | 0.38090 | NA | NA |
| SSX1 | crizotinib | 0.3809940 | 0.9092610 | 0.38099 | NA | NA |
| PML | sunitinib | 0.3810854 | 0.9092610 | 0.38109 | NA | NA |
| BRCA2 | trametinib | 0.3821071 | 0.9106280 | 0.38211 | NA | NA |
| EGFR | ruxolitinib | 0.3825743 | 0.9106280 | 0.38257 | NA | NA |
| FGFR1 | lapatinib | 0.3826658 | 0.9106280 | 0.38267 | NA | NA |
| STAT3 | trametinib | 0.3826976 | 0.9106280 | 0.38270 | NA | NA |
| NT5C2 | erlotinib | 0.3832044 | 0.9112153 | 0.38320 | NA | NA |
| CREBBP | fluorouracil | 0.3837396 | 0.9116375 | 0.38374 | NA | NA |
| CBL | lapatinib | 0.3845495 | 0.9116375 | 0.38455 | NA | NA |
| GATA3 | trametinib | 0.3851261 | 0.9116375 | 0.38513 | NA | NA |
| NOTCH1 | fluorouracil | 0.3852341 | 0.9116375 | 0.38523 | NA | NA |
| SRSF2 | crizotinib | 0.3856349 | 0.9116375 | 0.38563 | NA | NA |
| PML | dasatinib | 0.3857611 | 0.9116375 | 0.38576 | NA | NA |
| WHSC1 | belinostat | 0.3859879 | 0.9116375 | 0.38599 | NA | NA |
| FGFR3 | crizotinib | 0.3860496 | 0.9116375 | 0.38605 | NA | NA |
| SMC3 | cyclophosphamide | 0.3860521 | 0.9116375 | 0.38605 | NA | NA |
| RUNX1 | crizotinib | 0.3862705 | 0.9116375 | 0.38627 | NA | NA |
| PRPF8 | cyclophosphamide | 0.3864459 | 0.9116375 | 0.38645 | NA | NA |
| FLCN | vandetanib | 0.3869061 | 0.9116375 | 0.38691 | NA | NA |
| MPL | cabozantinib | 0.3873750 | 0.9116375 | 0.38737 | NA | NA |
| PIK3CA | olaparib | 0.3882401 | 0.9116375 | 0.38824 | NA | NA |
| CTNNB1 | nilotinib | 0.3882687 | 0.9116375 | 0.38827 | NA | NA |
| SMO | trametinib | 0.3884716 | 0.9116375 | 0.38847 | NA | NA |
| NRAS | cyclophosphamide | 0.3886743 | 0.9116375 | 0.38867 | NA | NA |
| TP53 | selumetinib | 0.3892339 | 0.9116375 | 0.38923 | NA | NA |
| U2AF1 | nilotinib | 0.3895544 | 0.9116375 | 0.38955 | NA | NA |
| CRLF2 | erlotinib | 0.3896002 | 0.9116375 | 0.38960 | NA | NA |
| SETBP1 | trametinib | 0.3903972 | 0.9116375 | 0.39040 | NA | NA |
| CD79B | cyclophosphamide | 0.3905066 | 0.9116375 | 0.39051 | NA | NA |
| IKZF1 | crizotinib | 0.3909441 | 0.9116375 | 0.39094 | NA | NA |
| CBL | erlotinib | 0.3910758 | 0.9116375 | 0.39108 | NA | NA |
| BCOR | sunitinib | 0.3911626 | 0.9116375 | 0.39116 | NA | NA |
| ZRSR2 | dasatinib | 0.3912721 | 0.9116375 | 0.39127 | NA | NA |
| BCOR | erlotinib | 0.3920392 | 0.9116375 | 0.39204 | NA | NA |
| MGMT | neratinib | 0.3926360 | 0.9116375 | 0.39264 | NA | NA |
| CD79B | gefitinib | 0.3926440 | 0.9116375 | 0.39264 | NA | NA |
| PML | afatinib | 0.3926441 | 0.9116375 | 0.39264 | NA | NA |
| GNAS | erlotinib | 0.3930691 | 0.9116375 | 0.39307 | NA | NA |
| DDIT3 | cyclophosphamide | 0.3932314 | 0.9116375 | 0.39323 | NA | NA |
| BRAF | cabozantinib | 0.3934771 | 0.9116375 | 0.39348 | NA | NA |
| ROS1 | vemurafenib | 0.3937304 | 0.9116375 | 0.39373 | NA | NA |
| JAK3 | vemurafenib | 0.3937969 | 0.9116375 | 0.39380 | NA | NA |
| CDK6 | belinostat | 0.3939894 | 0.9116375 | 0.39399 | NA | NA |
| SETD2 | cyclophosphamide | 0.3940681 | 0.9116375 | 0.39407 | NA | NA |
| SMC1A | cabozantinib | 0.3941443 | 0.9116375 | 0.39414 | NA | NA |
| GATA1 | dasatinib | 0.3943575 | 0.9116375 | 0.39436 | NA | NA |
| CREBBP | ibrutinib | 0.3946184 | 0.9116375 | 0.39462 | NA | NA |
| NT5C2 | vemurafenib | 0.3948753 | 0.9116375 | 0.39488 | NA | NA |
| IDH1 | crizotinib | 0.3953310 | 0.9116375 | 0.39533 | NA | NA |
| EGF | dabrafenib | 0.3954019 | 0.9116375 | 0.39540 | NA | NA |
| EED | afatinib | 0.3954378 | 0.9116375 | 0.39544 | NA | NA |
| SF1 | olaparib | 0.3954598 | 0.9116375 | 0.39546 | NA | NA |
| NCOA2 | vandetanib | 0.3955819 | 0.9116375 | 0.39558 | NA | NA |
| SSX1 | selumetinib | 0.3957972 | 0.9116375 | 0.39580 | NA | NA |
| NOTCH1 | olaparib | 0.3959243 | 0.9116375 | 0.39592 | NA | NA |
| GATA3 | ibrutinib | 0.3963945 | 0.9116375 | 0.39639 | NA | NA |
| SRSF2 | vemurafenib | 0.3967172 | 0.9116375 | 0.39672 | NA | NA |
| ERBB3 | dabrafenib | 0.3967421 | 0.9116375 | 0.39674 | NA | NA |
| ETV6 | sunitinib | 0.3969069 | 0.9116375 | 0.39691 | NA | NA |
| ZRSR2 | selumetinib | 0.3972457 | 0.9116424 | 0.39725 | NA | NA |
| TPMT | cyclophosphamide | 0.3978413 | 0.9116424 | 0.39784 | NA | NA |
| RET | belinostat | 0.3979105 | 0.9116424 | 0.39791 | NA | NA |
| SF1 | azd | 0.3985331 | 0.9116424 | 0.39853 | NA | NA |
| CDK4 | vandetanib | 0.3987542 | 0.9116424 | 0.39875 | NA | NA |
| SETD2 | nilotinib | 0.3988856 | 0.9116424 | 0.39889 | NA | NA |
| FGFR1 | selumetinib | 0.3995915 | 0.9116424 | 0.39959 | NA | NA |
| KMT2A | vandetanib | 0.3996239 | 0.9116424 | 0.39962 | NA | NA |
| ALK | dabrafenib | 0.3998459 | 0.9116424 | 0.39985 | NA | NA |
| XPO1 | afatinib | 0.3998625 | 0.9116424 | 0.39986 | NA | NA |
| PAX5 | belinostat | 0.3999643 | 0.9116424 | 0.39996 | NA | NA |
| GNAQ | ibrutinib | 0.4001427 | 0.9116424 | 0.40014 | NA | NA |
| SSX1 | ruxolitinib | 0.4002903 | 0.9116424 | 0.40029 | NA | NA |
| DDIT3 | cabozantinib | 0.4006322 | 0.9116655 | 0.40063 | NA | NA |
| GATA3 | fulvestrant | 0.4010641 | 0.9116655 | 0.40106 | NA | NA |
| PDGFRA | dasatinib | 0.4012694 | 0.9116655 | 0.40127 | NA | NA |
| FBXW7 | dabrafenib | 0.4014095 | 0.9116655 | 0.40141 | NA | NA |
| WT1 | erlotinib | 0.4016893 | 0.9116655 | 0.40169 | NA | NA |
| GATA2 | dasatinib | 0.4019852 | 0.9116655 | 0.40199 | NA | NA |
| CDC73 | ibrutinib | 0.4024500 | 0.9116655 | 0.40245 | NA | NA |
| PRPF8 | afatinib | 0.4024623 | 0.9116655 | 0.40246 | NA | NA |
| SMO | fulvestrant | 0.4026414 | 0.9116655 | 0.40264 | NA | NA |
| ZRSR2 | temozolomide | 0.4031694 | 0.9117303 | 0.40317 | NA | NA |
| NPM1 | vandetanib | 0.4033915 | 0.9117303 | 0.40339 | NA | NA |
| EZH2 | gefitinib | 0.4044061 | 0.9117303 | 0.40441 | NA | NA |
| NOTCH2 | imatinib | 0.4046381 | 0.9117303 | 0.40464 | NA | NA |
| CTCF | fulvestrant | 0.4054092 | 0.9117303 | 0.40541 | NA | NA |
| CSF3R | cabozantinib | 0.4055136 | 0.9117303 | 0.40551 | NA | NA |
| JAK3 | crizotinib | 0.4057871 | 0.9117303 | 0.40579 | NA | NA |
| EED | olaparib | 0.4060945 | 0.9117303 | 0.40609 | NA | NA |
| FANCL | vemurafenib | 0.4062049 | 0.9117303 | 0.40620 | NA | NA |
| CXCR4 | nilotinib | 0.4068026 | 0.9117303 | 0.40680 | NA | NA |
| CREBBP | trametinib | 0.4073521 | 0.9117303 | 0.40735 | NA | NA |
| SETD2 | ruxolitinib | 0.4075290 | 0.9117303 | 0.40753 | NA | NA |
| NRAS | regorafenib | 0.4075483 | 0.9117303 | 0.40755 | NA | NA |
| PML | ruxolitinib | 0.4077983 | 0.9117303 | 0.40780 | NA | NA |
| AKT1 | trametinib | 0.4079935 | 0.9117303 | 0.40799 | NA | NA |
| PHF6 | temozolomide | 0.4087934 | 0.9117303 | 0.40879 | NA | NA |
| KMT2A | fulvestrant | 0.4088668 | 0.9117303 | 0.40887 | NA | NA |
| JAK1 | regorafenib | 0.4090809 | 0.9117303 | 0.40908 | NA | NA |
| U2AF1 | azd | 0.4092599 | 0.9117303 | 0.40926 | NA | NA |
| TET2 | olaparib | 0.4096050 | 0.9117303 | 0.40960 | NA | NA |
| KIT | dabrafenib | 0.4097454 | 0.9117303 | 0.40975 | NA | NA |
| DNAJB1 | ibrutinib | 0.4100358 | 0.9117303 | 0.41004 | NA | NA |
| GNA11 | ibrutinib | 0.4100358 | 0.9117303 | 0.41004 | NA | NA |
| PAX5 | gefitinib | 0.4102469 | 0.9117303 | 0.41025 | NA | NA |
| RET | regorafenib | 0.4107421 | 0.9117303 | 0.41074 | NA | NA |
| BTK | erlotinib | 0.4110430 | 0.9117303 | 0.41104 | NA | NA |
| ERBB3 | vandetanib | 0.4111293 | 0.9117303 | 0.41113 | NA | NA |
| BCORL1 | cyclophosphamide | 0.4111667 | 0.9117303 | 0.41117 | NA | NA |
| KRAS | dabrafenib | 0.4111914 | 0.9117303 | 0.41119 | NA | NA |
| IDH1 | ibrutinib | 0.4113763 | 0.9117303 | 0.41138 | NA | NA |
| FGFR3 | vemurafenib | 0.4116024 | 0.9117303 | 0.41160 | NA | NA |
| CD274 | dabrafenib | 0.4128908 | 0.9117303 | 0.41289 | NA | NA |
| MAP2K2 | regorafenib | 0.4128919 | 0.9117303 | 0.41289 | NA | NA |
| DPYD | temozolomide | 0.4129554 | 0.9117303 | 0.41296 | NA | NA |
| EGF | neratinib | 0.4133712 | 0.9117303 | 0.41337 | NA | NA |
| CALR | selumetinib | 0.4138553 | 0.9117303 | 0.41386 | NA | NA |
| RUNX1 | gefitinib | 0.4140423 | 0.9117303 | 0.41404 | NA | NA |
| CBLB | selumetinib | 0.4145394 | 0.9117303 | 0.41454 | NA | NA |
| FLT3 | lapatinib | 0.4146955 | 0.9117303 | 0.41470 | NA | NA |
| FGFR1 | vemurafenib | 0.4148786 | 0.9117303 | 0.41488 | NA | NA |
| ESR1 | temozolomide | 0.4151428 | 0.9117303 | 0.41514 | NA | NA |
| ASXL1 | vandetanib | 0.4151524 | 0.9117303 | 0.41515 | NA | NA |
| BRCA2 | cabozantinib | 0.4162945 | 0.9117303 | 0.41629 | NA | NA |
| MAP2K2 | dasatinib | 0.4165738 | 0.9117303 | 0.41657 | NA | NA |
| FLCN | crizotinib | 0.4167697 | 0.9117303 | 0.41677 | NA | NA |
| TSC2 | trametinib | 0.4168352 | 0.9117303 | 0.41684 | NA | NA |
| NOTCH2 | olaparib | 0.4168942 | 0.9117303 | 0.41689 | NA | NA |
| PML | erlotinib | 0.4170584 | 0.9117303 | 0.41706 | NA | NA |
| SETD2 | crizotinib | 0.4172206 | 0.9117303 | 0.41722 | NA | NA |
| PIK3CA | trametinib | 0.4175242 | 0.9117303 | 0.41752 | NA | NA |
| GNAS | vandetanib | 0.4177244 | 0.9117303 | 0.41772 | NA | NA |
| GATA2 | neratinib | 0.4177941 | 0.9117303 | 0.41779 | NA | NA |
| VHL | cyclophosphamide | 0.4178333 | 0.9117303 | 0.41783 | NA | NA |
| HRAS | imatinib | 0.4180453 | 0.9117303 | 0.41805 | NA | NA |
| DDIT3 | sunitinib | 0.4181226 | 0.9117303 | 0.41812 | NA | NA |
| CYP19A1 | cabozantinib | 0.4181415 | 0.9117303 | 0.41814 | NA | NA |
| JAK2 | crizotinib | 0.4182454 | 0.9117303 | 0.41825 | NA | NA |
| GATA1 | pazopanib | 0.4183057 | 0.9117303 | 0.41831 | NA | NA |
| CBL | gefitinib | 0.4183863 | 0.9117303 | 0.41839 | NA | NA |
| ALK | fulvestrant | 0.4191815 | 0.9117303 | 0.41918 | NA | NA |
| PTCH1 | selumetinib | 0.4194027 | 0.9117303 | 0.41940 | NA | NA |
| PHF6 | erlotinib | 0.4194250 | 0.9117303 | 0.41942 | NA | NA |
| GATA2 | lapatinib | 0.4194980 | 0.9117303 | 0.41950 | NA | NA |
| SF3B1 | ruxolitinib | 0.4195779 | 0.9117303 | 0.41958 | NA | NA |
| MAP2K1 | lapatinib | 0.4195780 | 0.9117303 | 0.41958 | NA | NA |
| RAD21 | imatinib | 0.4203182 | 0.9123370 | 0.42032 | NA | NA |
| MAP2K2 | nilotinib | 0.4203778 | 0.9123370 | 0.42038 | NA | NA |
| WT1 | vandetanib | 0.4208522 | 0.9128013 | 0.42085 | NA | NA |
| GATA3 | crizotinib | 0.4211317 | 0.9128426 | 0.42113 | NA | NA |
| GNA11 | lapatinib | 0.4215123 | 0.9130515 | 0.42151 | NA | NA |
| GATA3 | vandetanib | 0.4219736 | 0.9130515 | 0.42197 | NA | NA |
| SETD2 | ibrutinib | 0.4220095 | 0.9130515 | 0.42201 | NA | NA |
| EGFR | dasatinib | 0.4226734 | 0.9134398 | 0.42267 | NA | NA |
| MPL | ruxolitinib | 0.4233563 | 0.9134398 | 0.42336 | NA | NA |
| BRCA2 | azd | 0.4237037 | 0.9134398 | 0.42370 | NA | NA |
| IDH1 | imatinib | 0.4237378 | 0.9134398 | 0.42374 | NA | NA |
| PDCD1 | ruxolitinib | 0.4243351 | 0.9134398 | 0.42434 | NA | NA |
| MAP2K2 | selumetinib | 0.4246944 | 0.9134398 | 0.42469 | NA | NA |
| GNAS | neratinib | 0.4249479 | 0.9134398 | 0.42495 | NA | NA |
| IDH1 | cabozantinib | 0.4252881 | 0.9134398 | 0.42529 | NA | NA |
| KIT | cyclophosphamide | 0.4256579 | 0.9134398 | 0.42566 | NA | NA |
| DNAJB1 | gefitinib | 0.4257652 | 0.9134398 | 0.42577 | NA | NA |
| PAX5 | olaparib | 0.4260006 | 0.9134398 | 0.42600 | NA | NA |
| CEBPA | trametinib | 0.4265139 | 0.9134398 | 0.42651 | NA | NA |
| KMT2A | lapatinib | 0.4265149 | 0.9134398 | 0.42651 | NA | NA |
| GNAS | pazopanib | 0.4265936 | 0.9134398 | 0.42659 | NA | NA |
| GNB1 | trametinib | 0.4271811 | 0.9134398 | 0.42718 | NA | NA |
| GATA1 | azd | 0.4273208 | 0.9134398 | 0.42732 | NA | NA |
| CDKN2A | regorafenib | 0.4273598 | 0.9134398 | 0.42736 | NA | NA |
| SMC1A | crizotinib | 0.4275659 | 0.9134398 | 0.42757 | NA | NA |
| NT5C2 | sunitinib | 0.4275958 | 0.9134398 | 0.42760 | NA | NA |
| VHL | fulvestrant | 0.4278977 | 0.9134398 | 0.42790 | NA | NA |
| AKT3 | fulvestrant | 0.4279549 | 0.9134398 | 0.42795 | NA | NA |
| PAX8 | vandetanib | 0.4285175 | 0.9134398 | 0.42852 | NA | NA |
| U2AF1 | vemurafenib | 0.4285987 | 0.9134398 | 0.42860 | NA | NA |
| FGFR2 | imatinib | 0.4290355 | 0.9134398 | 0.42904 | NA | NA |
| CRLF2 | cyclophosphamide | 0.4291379 | 0.9134398 | 0.42914 | NA | NA |
| ESR1 | ibrutinib | 0.4291778 | 0.9134398 | 0.42918 | NA | NA |
| EGFR | ibrutinib | 0.4292255 | 0.9134398 | 0.42923 | NA | NA |
| MAP2K2 | sunitinib | 0.4299316 | 0.9139458 | 0.42993 | NA | NA |
| IDH1 | nilotinib | 0.4302393 | 0.9139458 | 0.43024 | NA | NA |
| NPM1 | selumetinib | 0.4302455 | 0.9139458 | 0.43025 | NA | NA |
| SMC3 | vemurafenib | 0.4310406 | 0.9146526 | 0.43104 | NA | NA |
| PML | pazopanib | 0.4313542 | 0.9146526 | 0.43135 | NA | NA |
| GATA3 | gefitinib | 0.4313611 | 0.9146526 | 0.43136 | NA | NA |
| CBLB | fulvestrant | 0.4322063 | 0.9152554 | 0.43221 | NA | NA |
| CSF3R | fluorouracil | 0.4326326 | 0.9152554 | 0.43263 | NA | NA |
| TPMT | dabrafenib | 0.4326706 | 0.9152554 | 0.43267 | NA | NA |
| PRPF8 | selumetinib | 0.4326899 | 0.9152554 | 0.43269 | NA | NA |
| SF3B1 | vemurafenib | 0.4332669 | 0.9158515 | 0.43327 | NA | NA |
| VHL | trametinib | 0.4334943 | 0.9158515 | 0.43349 | NA | NA |
| PDGFRB | fluorouracil | 0.4341969 | 0.9167833 | 0.43420 | NA | NA |
| FANCL | gefitinib | 0.4351949 | 0.9171846 | 0.43519 | NA | NA |
| NRAS | gefitinib | 0.4351967 | 0.9171846 | 0.43520 | NA | NA |
| CALR | temozolomide | 0.4353983 | 0.9171846 | 0.43540 | NA | NA |
| PML | temozolomide | 0.4354604 | 0.9171846 | 0.43546 | NA | NA |
| ESR1 | cabozantinib | 0.4356954 | 0.9171846 | 0.43570 | NA | NA |
| PAX8 | vemurafenib | 0.4362243 | 0.9172349 | 0.43622 | NA | NA |
| ERBB3 | ruxolitinib | 0.4364470 | 0.9172349 | 0.43645 | NA | NA |
| GNAQ | sunitinib | 0.4365044 | 0.9172349 | 0.43650 | NA | NA |
| MYD88 | fulvestrant | 0.4383092 | 0.9194953 | 0.43831 | NA | NA |
| CYP19A1 | temozolomide | 0.4385706 | 0.9194953 | 0.43857 | NA | NA |
| IDH2 | trametinib | 0.4390903 | 0.9194953 | 0.43909 | NA | NA |
| RIT1 | trametinib | 0.4390903 | 0.9194953 | 0.43909 | NA | NA |
| NOTCH1 | vandetanib | 0.4391348 | 0.9194953 | 0.43913 | NA | NA |
| TET2 | cyclophosphamide | 0.4396624 | 0.9194953 | 0.43966 | NA | NA |
| SETBP1 | azd | 0.4396679 | 0.9194953 | 0.43967 | NA | NA |
| GNB1 | afatinib | 0.4396874 | 0.9194953 | 0.43969 | NA | NA |
| ESR1 | sunitinib | 0.4399411 | 0.9194953 | 0.43994 | NA | NA |
| BRCA2 | vandetanib | 0.4404474 | 0.9199608 | 0.44045 | NA | NA |
| CDC73 | afatinib | 0.4410135 | 0.9199608 | 0.44101 | NA | NA |
| PAX5 | dabrafenib | 0.4414102 | 0.9199608 | 0.44141 | NA | NA |
| CTNNB1 | trametinib | 0.4415898 | 0.9199608 | 0.44159 | NA | NA |
| MAP2K2 | pazopanib | 0.4419526 | 0.9199608 | 0.44195 | NA | NA |
| CD79B | vandetanib | 0.4420471 | 0.9199608 | 0.44205 | NA | NA |
| CDKN2A | cyclophosphamide | 0.4421122 | 0.9199608 | 0.44211 | NA | NA |
| PRPF8 | belinostat | 0.4422636 | 0.9199608 | 0.44226 | NA | NA |
| CTNNB1 | imatinib | 0.4427480 | 0.9203925 | 0.44275 | NA | NA |
| WHSC1 | temozolomide | 0.4429963 | 0.9203925 | 0.44300 | NA | NA |
| IDH2 | selumetinib | 0.4434340 | 0.9207561 | 0.44343 | NA | NA |
| CRLF2 | pazopanib | 0.4445080 | 0.9216936 | 0.44451 | NA | NA |
| MYCN | crizotinib | 0.4447263 | 0.9216936 | 0.44473 | NA | NA |
| ALK | nilotinib | 0.4451309 | 0.9216936 | 0.44513 | NA | NA |
| PAX5 | vandetanib | 0.4453052 | 0.9216936 | 0.44531 | NA | NA |
| PRPF8 | dabrafenib | 0.4454512 | 0.9216936 | 0.44545 | NA | NA |
| PAX8 | azd | 0.4457725 | 0.9216936 | 0.44577 | NA | NA |
| CRLF2 | cabozantinib | 0.4458442 | 0.9216936 | 0.44584 | NA | NA |
| ATM | pazopanib | 0.4459893 | 0.9216936 | 0.44599 | NA | NA |
| CEBPA | lapatinib | 0.4465735 | 0.9222727 | 0.44657 | NA | NA |
| CALR | trametinib | 0.4467957 | 0.9222727 | 0.44680 | NA | NA |
| GATA3 | dabrafenib | 0.4474134 | 0.9230040 | 0.44741 | NA | NA |
| JAK3 | regorafenib | 0.4481858 | 0.9237806 | 0.44819 | NA | NA |
| CRLF2 | gefitinib | 0.4484655 | 0.9237806 | 0.44847 | NA | NA |
| GNB1 | fluorouracil | 0.4488380 | 0.9237806 | 0.44884 | NA | NA |
| TSC2 | neratinib | 0.4493579 | 0.9237806 | 0.44936 | NA | NA |
| SH2B3 | ibrutinib | 0.4493608 | 0.9237806 | 0.44936 | NA | NA |
| MET | temozolomide | 0.4496757 | 0.9237806 | 0.44968 | NA | NA |
| ASXL1 | regorafenib | 0.4498559 | 0.9237806 | 0.44986 | NA | NA |
| FGFR3 | temozolomide | 0.4502745 | 0.9237806 | 0.45027 | NA | NA |
| PDCD1 | azd | 0.4503246 | 0.9237806 | 0.45032 | NA | NA |
| FLCN | trametinib | 0.4504254 | 0.9237806 | 0.45043 | NA | NA |
| CDKN2A | azd | 0.4513087 | 0.9250508 | 0.45131 | NA | NA |
| FBXW7 | ibrutinib | 0.4529024 | 0.9255348 | 0.45290 | NA | NA |
| SMC3 | sunitinib | 0.4535089 | 0.9255348 | 0.45351 | NA | NA |
| AR | azd | 0.4540551 | 0.9255348 | 0.45406 | NA | NA |
| SMC3 | afatinib | 0.4544069 | 0.9255348 | 0.45441 | NA | NA |
| ASXL1 | belinostat | 0.4546733 | 0.9255348 | 0.45467 | NA | NA |
| ERBB3 | pazopanib | 0.4547800 | 0.9255348 | 0.45478 | NA | NA |
| FGFR2 | regorafenib | 0.4554646 | 0.9255348 | 0.45546 | NA | NA |
| IL7R | olaparib | 0.4555569 | 0.9255348 | 0.45556 | NA | NA |
| EED | crizotinib | 0.4560361 | 0.9255348 | 0.45604 | NA | NA |
| CDKN2A | vemurafenib | 0.4566814 | 0.9255348 | 0.45668 | NA | NA |
| FGFR2 | ruxolitinib | 0.4566858 | 0.9255348 | 0.45669 | NA | NA |
| SRSF2 | erlotinib | 0.4568633 | 0.9255348 | 0.45686 | NA | NA |
| XPO1 | gefitinib | 0.4568797 | 0.9255348 | 0.45688 | NA | NA |
| NOTCH2 | dabrafenib | 0.4572129 | 0.9255348 | 0.45721 | NA | NA |
| IDH2 | dasatinib | 0.4572773 | 0.9255348 | 0.45728 | NA | NA |
| ESR1 | erlotinib | 0.4580536 | 0.9255348 | 0.45805 | NA | NA |
| STAT3 | gefitinib | 0.4584552 | 0.9255348 | 0.45846 | NA | NA |
| KMT2A | neratinib | 0.4586028 | 0.9255348 | 0.45860 | NA | NA |
| SF3B1 | nilotinib | 0.4586487 | 0.9255348 | 0.45865 | NA | NA |
| HRAS | dabrafenib | 0.4590006 | 0.9255348 | 0.45900 | NA | NA |
| ZRSR2 | olaparib | 0.4592341 | 0.9255348 | 0.45923 | NA | NA |
| BRAF | erlotinib | 0.4592476 | 0.9255348 | 0.45925 | NA | NA |
| CBLB | neratinib | 0.4593277 | 0.9255348 | 0.45933 | NA | NA |
| G6PD | vemurafenib | 0.4602214 | 0.9255348 | 0.46022 | NA | NA |
| CSF3R | temozolomide | 0.4603198 | 0.9255348 | 0.46032 | NA | NA |
| U2AF1 | olaparib | 0.4607373 | 0.9255348 | 0.46074 | NA | NA |
| EED | erlotinib | 0.4608210 | 0.9255348 | 0.46082 | NA | NA |
| ESR1 | vemurafenib | 0.4616314 | 0.9255348 | 0.46163 | NA | NA |
| SMO | erlotinib | 0.4618073 | 0.9255348 | 0.46181 | NA | NA |
| BCOR | gefitinib | 0.4620960 | 0.9255348 | 0.46210 | NA | NA |
| BRAF | vandetanib | 0.4622785 | 0.9255348 | 0.46228 | NA | NA |
| PAX5 | ruxolitinib | 0.4625351 | 0.9255348 | 0.46254 | NA | NA |
| NOTCH2 | sunitinib | 0.4626037 | 0.9255348 | 0.46260 | NA | NA |
| NOTCH1 | regorafenib | 0.4626857 | 0.9255348 | 0.46269 | NA | NA |
| NOTCH1 | azd | 0.4629356 | 0.9255348 | 0.46294 | NA | NA |
| IDH1 | erlotinib | 0.4630798 | 0.9255348 | 0.46308 | NA | NA |
| ETV6 | selumetinib | 0.4631578 | 0.9255348 | 0.46316 | NA | NA |
| SMC1A | neratinib | 0.4636153 | 0.9255348 | 0.46362 | NA | NA |
| CDC73 | vandetanib | 0.4637074 | 0.9255348 | 0.46371 | NA | NA |
| GNB1 | sunitinib | 0.4638416 | 0.9255348 | 0.46384 | NA | NA |
| CDKN2A | trametinib | 0.4639190 | 0.9255348 | 0.46392 | NA | NA |
| PDGFB | fluorouracil | 0.4641195 | 0.9255348 | 0.46412 | NA | NA |
| MGMT | sunitinib | 0.4645056 | 0.9255348 | 0.46451 | NA | NA |
| SMC3 | cabozantinib | 0.4648918 | 0.9255348 | 0.46489 | NA | NA |
| CRLF2 | sunitinib | 0.4654227 | 0.9255348 | 0.46542 | NA | NA |
| JAK2 | sunitinib | 0.4660324 | 0.9255348 | 0.46603 | NA | NA |
| FLT3 | regorafenib | 0.4660591 | 0.9255348 | 0.46606 | NA | NA |
| ETV6 | crizotinib | 0.4661265 | 0.9255348 | 0.46613 | NA | NA |
| G6PD | fluorouracil | 0.4661924 | 0.9255348 | 0.46619 | NA | NA |
| ABL1 | gefitinib | 0.4664039 | 0.9255348 | 0.46640 | NA | NA |
| SRSF2 | cabozantinib | 0.4665096 | 0.9255348 | 0.46651 | NA | NA |
| CDC73 | ruxolitinib | 0.4667059 | 0.9255348 | 0.46671 | NA | NA |
| PIK3CA | pazopanib | 0.4671097 | 0.9255348 | 0.46711 | NA | NA |
| CEBPA | cyclophosphamide | 0.4673632 | 0.9255348 | 0.46736 | NA | NA |
| SH2B3 | imatinib | 0.4675138 | 0.9255348 | 0.46751 | NA | NA |
| FGFR3 | erlotinib | 0.4675285 | 0.9255348 | 0.46753 | NA | NA |
| GNAS | cyclophosphamide | 0.4676333 | 0.9255348 | 0.46763 | NA | NA |
| XPO1 | ibrutinib | 0.4676501 | 0.9255348 | 0.46765 | NA | NA |
| CTNNB1 | pazopanib | 0.4677888 | 0.9255348 | 0.46779 | NA | NA |
| AKT1 | ruxolitinib | 0.4679864 | 0.9255348 | 0.46799 | NA | NA |
| AR | gefitinib | 0.4681152 | 0.9255348 | 0.46812 | NA | NA |
| RIT1 | nilotinib | 0.4682565 | 0.9255348 | 0.46826 | NA | NA |
| GNAQ | dasatinib | 0.4691052 | 0.9255348 | 0.46911 | NA | NA |
| SSX1 | dasatinib | 0.4691052 | 0.9255348 | 0.46911 | NA | NA |
| CEBPA | dabrafenib | 0.4696707 | 0.9255348 | 0.46967 | NA | NA |
| CBLB | sunitinib | 0.4697197 | 0.9255348 | 0.46972 | NA | NA |
| CDK4 | vemurafenib | 0.4700887 | 0.9255348 | 0.47009 | NA | NA |
| ERBB4 | pazopanib | 0.4701323 | 0.9255348 | 0.47013 | NA | NA |
| CTCF | selumetinib | 0.4703252 | 0.9255348 | 0.47033 | NA | NA |
| TPMT | ibrutinib | 0.4703605 | 0.9255348 | 0.47036 | NA | NA |
| FGFR2 | dabrafenib | 0.4703617 | 0.9255348 | 0.47036 | NA | NA |
| GATA1 | gefitinib | 0.4710145 | 0.9255348 | 0.47101 | NA | NA |
| CSF3R | regorafenib | 0.4710591 | 0.9255348 | 0.47106 | NA | NA |
| NCOA2 | azd | 0.4710853 | 0.9255348 | 0.47109 | NA | NA |
| CTNNB1 | cyclophosphamide | 0.4725215 | 0.9269992 | 0.47252 | NA | NA |
| PAX8 | crizotinib | 0.4728356 | 0.9269992 | 0.47284 | NA | NA |
| EML4 | dabrafenib | 0.4729837 | 0.9269992 | 0.47298 | NA | NA |
| IKZF1 | vemurafenib | 0.4736493 | 0.9269992 | 0.47365 | NA | NA |
| U2AF1 | fluorouracil | 0.4737793 | 0.9269992 | 0.47378 | NA | NA |
| DNMT3A | cabozantinib | 0.4741169 | 0.9269992 | 0.47412 | NA | NA |
| ERBB2 | azd | 0.4751190 | 0.9269992 | 0.47512 | NA | NA |
| PAX8 | cyclophosphamide | 0.4756508 | 0.9269992 | 0.47565 | NA | NA |
| WT1 | belinostat | 0.4756747 | 0.9269992 | 0.47567 | NA | NA |
| CD274 | vemurafenib | 0.4757412 | 0.9269992 | 0.47574 | NA | NA |
| CYP19A1 | azd | 0.4757453 | 0.9269992 | 0.47575 | NA | NA |
| KIT | regorafenib | 0.4759780 | 0.9269992 | 0.47598 | NA | NA |
| CYP19A1 | selumetinib | 0.4763756 | 0.9269992 | 0.47638 | NA | NA |
| UGT1A1 | fluorouracil | 0.4767219 | 0.9269992 | 0.47672 | NA | NA |
| PAX5 | vemurafenib | 0.4768032 | 0.9269992 | 0.47680 | NA | NA |
| FGFR3 | selumetinib | 0.4771381 | 0.9269992 | 0.47714 | NA | NA |
| ETV6 | nilotinib | 0.4777851 | 0.9269992 | 0.47779 | NA | NA |
| EED | lapatinib | 0.4778239 | 0.9269992 | 0.47782 | NA | NA |
| BRCA2 | afatinib | 0.4780707 | 0.9269992 | 0.47807 | NA | NA |
| MDM2 | afatinib | 0.4782523 | 0.9269992 | 0.47825 | NA | NA |
| MYD88 | trametinib | 0.4783281 | 0.9269992 | 0.47833 | NA | NA |
| XPO1 | olaparib | 0.4785953 | 0.9269992 | 0.47860 | NA | NA |
| AR | sunitinib | 0.4786216 | 0.9269992 | 0.47862 | NA | NA |
| BRCA2 | crizotinib | 0.4789637 | 0.9269992 | 0.47896 | NA | NA |
| PIK3CA | temozolomide | 0.4791807 | 0.9269992 | 0.47918 | NA | NA |
| BRCA1 | neratinib | 0.4793342 | 0.9269992 | 0.47933 | NA | NA |
| MAP2K1 | pazopanib | 0.4793953 | 0.9269992 | 0.47940 | NA | NA |
| JAK1 | lapatinib | 0.4795310 | 0.9269992 | 0.47953 | NA | NA |
| SETD2 | neratinib | 0.4797126 | 0.9269992 | 0.47971 | NA | NA |
| CDK6 | cabozantinib | 0.4797651 | 0.9269992 | 0.47977 | NA | NA |
| BRCA1 | imatinib | 0.4803511 | 0.9276202 | 0.48035 | NA | NA |
| SSX1 | neratinib | 0.4812085 | 0.9278467 | 0.48121 | NA | NA |
| G6PD | dasatinib | 0.4813514 | 0.9278467 | 0.48135 | NA | NA |
| NOTCH1 | belinostat | 0.4814267 | 0.9278467 | 0.48143 | NA | NA |
| EGFR | dabrafenib | 0.4817681 | 0.9278467 | 0.48177 | NA | NA |
| JAK2 | trametinib | 0.4825043 | 0.9278467 | 0.48250 | NA | NA |
| G6PD | lapatinib | 0.4825811 | 0.9278467 | 0.48258 | NA | NA |
| IDH2 | pazopanib | 0.4829493 | 0.9278467 | 0.48295 | NA | NA |
| ABL1 | selumetinib | 0.4835135 | 0.9278467 | 0.48351 | NA | NA |
| MGMT | belinostat | 0.4836415 | 0.9278467 | 0.48364 | NA | NA |
| BRCA2 | belinostat | 0.4837494 | 0.9278467 | 0.48375 | NA | NA |
| DDIT3 | ibrutinib | 0.4844242 | 0.9278467 | 0.48442 | NA | NA |
| FLT3 | belinostat | 0.4844586 | 0.9278467 | 0.48446 | NA | NA |
| AR | erlotinib | 0.4846917 | 0.9278467 | 0.48469 | NA | NA |
| CBL | azd | 0.4848329 | 0.9278467 | 0.48483 | NA | NA |
| BRCA1 | fluorouracil | 0.4849343 | 0.9278467 | 0.48493 | NA | NA |
| SSX1 | lapatinib | 0.4855081 | 0.9278467 | 0.48551 | NA | NA |
| ASXL1 | lapatinib | 0.4855460 | 0.9278467 | 0.48555 | NA | NA |
| PTPN11 | dasatinib | 0.4856387 | 0.9278467 | 0.48564 | NA | NA |
| CSF3R | belinostat | 0.4857383 | 0.9278467 | 0.48574 | NA | NA |
| NCOA2 | crizotinib | 0.4858215 | 0.9278467 | 0.48582 | NA | NA |
| PTPN11 | afatinib | 0.4862945 | 0.9278467 | 0.48629 | NA | NA |
| PDCD1 | dabrafenib | 0.4870789 | 0.9278467 | 0.48708 | NA | NA |
| DNMT3A | temozolomide | 0.4872219 | 0.9278467 | 0.48722 | NA | NA |
| ALK | regorafenib | 0.4873433 | 0.9278467 | 0.48734 | NA | NA |
| ATM | lapatinib | 0.4875162 | 0.9278467 | 0.48752 | NA | NA |
| U2AF1 | vandetanib | 0.4876100 | 0.9278467 | 0.48761 | NA | NA |
| DPYD | ruxolitinib | 0.4879108 | 0.9278467 | 0.48791 | NA | NA |
| EZH2 | selumetinib | 0.4883319 | 0.9278467 | 0.48833 | NA | NA |
| BTK | cyclophosphamide | 0.4883778 | 0.9278467 | 0.48838 | NA | NA |
| BCOR | vandetanib | 0.4890624 | 0.9278467 | 0.48906 | NA | NA |
| CD274 | belinostat | 0.4892836 | 0.9278467 | 0.48928 | NA | NA |
| DNAJB1 | regorafenib | 0.4897697 | 0.9278467 | 0.48977 | NA | NA |
| MET | afatinib | 0.4898065 | 0.9278467 | 0.48981 | NA | NA |
| SH2B3 | afatinib | 0.4899403 | 0.9278467 | 0.48994 | NA | NA |
| WHSC1 | regorafenib | 0.4899992 | 0.9278467 | 0.49000 | NA | NA |
| RPL10 | lapatinib | 0.4900257 | 0.9278467 | 0.49003 | NA | NA |
| PDGFRA | neratinib | 0.4902631 | 0.9278467 | 0.49026 | NA | NA |
| GNAQ | ruxolitinib | 0.4905906 | 0.9279655 | 0.49059 | NA | NA |
| RUNX1 | pazopanib | 0.4925311 | 0.9307389 | 0.49253 | NA | NA |
| CDK4 | temozolomide | 0.4927602 | 0.9307389 | 0.49276 | NA | NA |
| FBXW7 | trametinib | 0.4930321 | 0.9307389 | 0.49303 | NA | NA |
| BCORL1 | lapatinib | 0.4933397 | 0.9307389 | 0.49334 | NA | NA |
| DNAJB1 | selumetinib | 0.4936501 | 0.9307389 | 0.49365 | NA | NA |
| MGMT | crizotinib | 0.4938707 | 0.9307389 | 0.49387 | NA | NA |
| RIT1 | lapatinib | 0.4944175 | 0.9307389 | 0.49442 | NA | NA |
| SF3B1 | ibrutinib | 0.4946447 | 0.9307389 | 0.49464 | NA | NA |
| SH2B3 | vemurafenib | 0.4946802 | 0.9307389 | 0.49468 | NA | NA |
| PRPF8 | vandetanib | 0.4948851 | 0.9307389 | 0.49489 | NA | NA |
| TSC1 | vandetanib | 0.4950385 | 0.9307389 | 0.49504 | NA | NA |
| DPYD | lapatinib | 0.4952434 | 0.9307389 | 0.49524 | NA | NA |
| GNA11 | afatinib | 0.4958414 | 0.9310349 | 0.49584 | NA | NA |
| SMC1A | olaparib | 0.4960568 | 0.9310349 | 0.49606 | NA | NA |
| GATA1 | vemurafenib | 0.4961978 | 0.9310349 | 0.49620 | NA | NA |
| SETBP1 | nilotinib | 0.4965845 | 0.9312236 | 0.49658 | NA | NA |
| PTCH1 | pazopanib | 0.4968297 | 0.9312236 | 0.49683 | NA | NA |
| PRPF8 | dasatinib | 0.4974984 | 0.9319785 | 0.49750 | NA | NA |
| STAG2 | vandetanib | 0.4981905 | 0.9327766 | 0.49819 | NA | NA |
| EED | temozolomide | 0.4985623 | 0.9329744 | 0.49856 | NA | NA |
| EED | regorafenib | 0.4993179 | 0.9332424 | 0.49932 | NA | NA |
| ERBB4 | afatinib | 0.4994235 | 0.9332424 | 0.49942 | NA | NA |
| CDK6 | gefitinib | 0.4995044 | 0.9332424 | 0.49950 | NA | NA |
| IL7R | ibrutinib | 0.5005914 | 0.9347751 | 0.50059 | NA | NA |
| SETBP1 | cabozantinib | 0.5016169 | 0.9353377 | 0.50162 | NA | NA |
| ASXL1 | trametinib | 0.5016499 | 0.9353377 | 0.50165 | NA | NA |
| PTPN11 | olaparib | 0.5016933 | 0.9353377 | 0.50169 | NA | NA |
| BTK | regorafenib | 0.5020376 | 0.9354821 | 0.50204 | NA | NA |
| CD274 | cabozantinib | 0.5026289 | 0.9360862 | 0.50263 | NA | NA |
| TSC1 | temozolomide | 0.5032091 | 0.9362097 | 0.50321 | NA | NA |
| EGF | azd | 0.5032808 | 0.9362097 | 0.50328 | NA | NA |
| SH2B3 | dabrafenib | 0.5040226 | 0.9362097 | 0.50402 | NA | NA |
| GNAS | olaparib | 0.5040697 | 0.9362097 | 0.50407 | NA | NA |
| DPYD | cyclophosphamide | 0.5045811 | 0.9362097 | 0.50458 | NA | NA |
| NOTCH2 | fluorouracil | 0.5047894 | 0.9362097 | 0.50479 | NA | NA |
| WT1 | ibrutinib | 0.5054016 | 0.9362097 | 0.50540 | NA | NA |
| CBL | trametinib | 0.5054059 | 0.9362097 | 0.50541 | NA | NA |
| SETD2 | dabrafenib | 0.5055253 | 0.9362097 | 0.50553 | NA | NA |
| SMC1A | selumetinib | 0.5061254 | 0.9362097 | 0.50613 | NA | NA |
| STAG2 | afatinib | 0.5067070 | 0.9362097 | 0.50671 | NA | NA |
| SMC3 | nilotinib | 0.5067861 | 0.9362097 | 0.50679 | NA | NA |
| IL7R | dabrafenib | 0.5068744 | 0.9362097 | 0.50687 | NA | NA |
| ASXL1 | pazopanib | 0.5069058 | 0.9362097 | 0.50691 | NA | NA |
| CTLA4 | sunitinib | 0.5069426 | 0.9362097 | 0.50694 | NA | NA |
| CALR | lapatinib | 0.5069689 | 0.9362097 | 0.50697 | NA | NA |
| CSF3R | afatinib | 0.5086090 | 0.9387438 | 0.50861 | NA | NA |
| IKZF1 | trametinib | 0.5091759 | 0.9390581 | 0.50918 | NA | NA |
| MAP2K2 | ibrutinib | 0.5093151 | 0.9390581 | 0.50932 | NA | NA |
| IL7R | vandetanib | 0.5102205 | 0.9393471 | 0.51022 | NA | NA |
| AR | neratinib | 0.5105201 | 0.9393471 | 0.51052 | NA | NA |
| CBL | regorafenib | 0.5115246 | 0.9393471 | 0.51152 | NA | NA |
| NOTCH1 | pazopanib | 0.5116110 | 0.9393471 | 0.51161 | NA | NA |
| RET | sunitinib | 0.5118218 | 0.9393471 | 0.51182 | NA | NA |
| CDC73 | olaparib | 0.5122274 | 0.9393471 | 0.51223 | NA | NA |
| DPYD | trametinib | 0.5123073 | 0.9393471 | 0.51231 | NA | NA |
| UGT1A1 | trametinib | 0.5123562 | 0.9393471 | 0.51236 | NA | NA |
| WHSC1 | afatinib | 0.5124593 | 0.9393471 | 0.51246 | NA | NA |
| FANCL | azd | 0.5129228 | 0.9393471 | 0.51292 | NA | NA |
| CD79B | neratinib | 0.5130945 | 0.9393471 | 0.51309 | NA | NA |
| PML | lapatinib | 0.5131940 | 0.9393471 | 0.51319 | NA | NA |
| ZRSR2 | cyclophosphamide | 0.5133998 | 0.9393471 | 0.51340 | NA | NA |
| SMC1A | fulvestrant | 0.5136425 | 0.9393471 | 0.51364 | NA | NA |
| STAG2 | ibrutinib | 0.5139402 | 0.9393471 | 0.51394 | NA | NA |
| NRAS | fulvestrant | 0.5139936 | 0.9393471 | 0.51399 | NA | NA |
| WHSC1 | fulvestrant | 0.5140279 | 0.9393471 | 0.51403 | NA | NA |
| DDIT3 | neratinib | 0.5143581 | 0.9394607 | 0.51436 | NA | NA |
| GNB1 | cyclophosphamide | 0.5150699 | 0.9402708 | 0.51507 | NA | NA |
| NCOA2 | afatinib | 0.5161837 | 0.9402792 | 0.51618 | NA | NA |
| RIT1 | cyclophosphamide | 0.5164134 | 0.9402792 | 0.51641 | NA | NA |
| BCOR | afatinib | 0.5167157 | 0.9402792 | 0.51672 | NA | NA |
| U2AF1 | afatinib | 0.5168031 | 0.9402792 | 0.51680 | NA | NA |
| MET | neratinib | 0.5169277 | 0.9402792 | 0.51693 | NA | NA |
| RET | pazopanib | 0.5175936 | 0.9402792 | 0.51759 | NA | NA |
| TSC2 | ruxolitinib | 0.5176922 | 0.9402792 | 0.51769 | NA | NA |
| DPYD | dabrafenib | 0.5177549 | 0.9402792 | 0.51775 | NA | NA |
| NOTCH1 | temozolomide | 0.5178042 | 0.9402792 | 0.51780 | NA | NA |
| MAP2K2 | azd | 0.5179526 | 0.9402792 | 0.51795 | NA | NA |
| BRCA1 | gefitinib | 0.5187110 | 0.9402792 | 0.51871 | NA | NA |
| PDGFRA | nilotinib | 0.5194411 | 0.9402792 | 0.51944 | NA | NA |
| FGFR2 | sunitinib | 0.5196058 | 0.9402792 | 0.51961 | NA | NA |
| ABL1 | regorafenib | 0.5196255 | 0.9402792 | 0.51963 | NA | NA |
| ATM | fulvestrant | 0.5202454 | 0.9402792 | 0.52025 | NA | NA |
| U2AF1 | sunitinib | 0.5205839 | 0.9402792 | 0.52058 | NA | NA |
| AKT3 | trametinib | 0.5207009 | 0.9402792 | 0.52070 | NA | NA |
| CDK4 | crizotinib | 0.5207399 | 0.9402792 | 0.52074 | NA | NA |
| RIT1 | cabozantinib | 0.5210929 | 0.9402792 | 0.52109 | NA | NA |
| IKZF1 | neratinib | 0.5215096 | 0.9402792 | 0.52151 | NA | NA |
| CBLB | cyclophosphamide | 0.5219882 | 0.9402792 | 0.52199 | NA | NA |
| STAT3 | temozolomide | 0.5221724 | 0.9402792 | 0.52217 | NA | NA |
| NPM1 | gefitinib | 0.5229480 | 0.9402792 | 0.52295 | NA | NA |
| SF1 | belinostat | 0.5231187 | 0.9402792 | 0.52312 | NA | NA |
| GNB1 | vemurafenib | 0.5232772 | 0.9402792 | 0.52328 | NA | NA |
| DPYD | regorafenib | 0.5244529 | 0.9402792 | 0.52445 | NA | NA |
| CTCF | neratinib | 0.5245165 | 0.9402792 | 0.52452 | NA | NA |
| NCOA2 | cyclophosphamide | 0.5245474 | 0.9402792 | 0.52455 | NA | NA |
| MYCN | ibrutinib | 0.5250844 | 0.9402792 | 0.52508 | NA | NA |
| FGFR3 | dabrafenib | 0.5253814 | 0.9402792 | 0.52538 | NA | NA |
| PAX8 | fulvestrant | 0.5259576 | 0.9402792 | 0.52596 | NA | NA |
| MPL | trametinib | 0.5260170 | 0.9402792 | 0.52602 | NA | NA |
| FBXW7 | cabozantinib | 0.5263715 | 0.9402792 | 0.52637 | NA | NA |
| FLCN | dasatinib | 0.5272924 | 0.9402792 | 0.52729 | NA | NA |
| FGFR3 | ibrutinib | 0.5276402 | 0.9402792 | 0.52764 | NA | NA |
| AKT2 | temozolomide | 0.5277255 | 0.9402792 | 0.52773 | NA | NA |
| ZRSR2 | ruxolitinib | 0.5278655 | 0.9402792 | 0.52787 | NA | NA |
| BRCA2 | olaparib | 0.5281161 | 0.9402792 | 0.52812 | NA | NA |
| FGFR3 | pazopanib | 0.5287975 | 0.9402792 | 0.52880 | NA | NA |
| CDKN2A | vandetanib | 0.5289686 | 0.9402792 | 0.52897 | NA | NA |
| ETV6 | ibrutinib | 0.5289813 | 0.9402792 | 0.52898 | NA | NA |
| DNMT3A | nilotinib | 0.5289852 | 0.9402792 | 0.52899 | NA | NA |
| FLCN | regorafenib | 0.5296745 | 0.9402792 | 0.52967 | NA | NA |
| PDCD1 | pazopanib | 0.5298328 | 0.9402792 | 0.52983 | NA | NA |
| MYCN | pazopanib | 0.5299508 | 0.9402792 | 0.52995 | NA | NA |
| HRAS | temozolomide | 0.5303032 | 0.9402792 | 0.53030 | NA | NA |
| AKT1 | cyclophosphamide | 0.5303222 | 0.9402792 | 0.53032 | NA | NA |
| PDGFRA | ruxolitinib | 0.5303811 | 0.9402792 | 0.53038 | NA | NA |
| FGFR3 | nilotinib | 0.5306141 | 0.9402792 | 0.53061 | NA | NA |
| RIT1 | vemurafenib | 0.5306802 | 0.9402792 | 0.53068 | NA | NA |
| SMC3 | vandetanib | 0.5307791 | 0.9402792 | 0.53078 | NA | NA |
| FGFR1 | ruxolitinib | 0.5310554 | 0.9402792 | 0.53106 | NA | NA |
| DNAJB1 | vemurafenib | 0.5316009 | 0.9402792 | 0.53160 | NA | NA |
| MDM2 | dasatinib | 0.5317965 | 0.9402792 | 0.53180 | NA | NA |
| RAD21 | nilotinib | 0.5318933 | 0.9402792 | 0.53189 | NA | NA |
| KIT | sunitinib | 0.5322976 | 0.9402792 | 0.53230 | NA | NA |
| CREBBP | olaparib | 0.5325820 | 0.9402792 | 0.53258 | NA | NA |
| SETBP1 | belinostat | 0.5325831 | 0.9402792 | 0.53258 | NA | NA |
| RAD21 | belinostat | 0.5327061 | 0.9402792 | 0.53271 | NA | NA |
| PDCD1 | gefitinib | 0.5327619 | 0.9402792 | 0.53276 | NA | NA |
| JAK3 | fulvestrant | 0.5327807 | 0.9402792 | 0.53278 | NA | NA |
| SMO | belinostat | 0.5328601 | 0.9402792 | 0.53286 | NA | NA |
| NOTCH1 | dasatinib | 0.5329670 | 0.9402792 | 0.53297 | NA | NA |
| FLCN | selumetinib | 0.5330953 | 0.9402792 | 0.53310 | NA | NA |
| FLT3 | dasatinib | 0.5331194 | 0.9402792 | 0.53312 | NA | NA |
| SMO | gefitinib | 0.5331898 | 0.9402792 | 0.53319 | NA | NA |
| NRAS | olaparib | 0.5332603 | 0.9402792 | 0.53326 | NA | NA |
| PTPN11 | cyclophosphamide | 0.5334607 | 0.9402792 | 0.53346 | NA | NA |
| JAK1 | gefitinib | 0.5335975 | 0.9402792 | 0.53360 | NA | NA |
| SH2B3 | cabozantinib | 0.5342347 | 0.9402792 | 0.53423 | NA | NA |
| SF3B1 | fulvestrant | 0.5343453 | 0.9402792 | 0.53435 | NA | NA |
| NOTCH1 | ruxolitinib | 0.5348704 | 0.9402792 | 0.53487 | NA | NA |
| DDIT3 | pazopanib | 0.5350110 | 0.9402792 | 0.53501 | NA | NA |
| PIK3CA | nilotinib | 0.5354677 | 0.9402792 | 0.53547 | NA | NA |
| PRPF8 | fluorouracil | 0.5356521 | 0.9402792 | 0.53565 | NA | NA |
| G6PD | cyclophosphamide | 0.5360224 | 0.9402792 | 0.53602 | NA | NA |
| ERBB3 | crizotinib | 0.5361343 | 0.9402792 | 0.53613 | NA | NA |
| BTK | vandetanib | 0.5361848 | 0.9402792 | 0.53618 | NA | NA |
| FGFR3 | afatinib | 0.5362677 | 0.9402792 | 0.53627 | NA | NA |
| TET2 | temozolomide | 0.5366331 | 0.9404495 | 0.53663 | NA | NA |
| IL7R | crizotinib | 0.5372087 | 0.9407803 | 0.53721 | NA | NA |
| GNAQ | nilotinib | 0.5373587 | 0.9407803 | 0.53736 | NA | NA |
| NOTCH2 | cabozantinib | 0.5382614 | 0.9418902 | 0.53826 | NA | NA |
| MYD88 | imatinib | 0.5393201 | 0.9426638 | 0.53932 | NA | NA |
| TSC1 | lapatinib | 0.5398720 | 0.9426638 | 0.53987 | NA | NA |
| CTNNB1 | sunitinib | 0.5402849 | 0.9426638 | 0.54028 | NA | NA |
| STAG2 | azd | 0.5404441 | 0.9426638 | 0.54044 | NA | NA |
| RET | vemurafenib | 0.5409337 | 0.9426638 | 0.54093 | NA | NA |
| ATM | olaparib | 0.5410315 | 0.9426638 | 0.54103 | NA | NA |
| GATA3 | azd | 0.5411533 | 0.9426638 | 0.54115 | NA | NA |
| NOTCH1 | lapatinib | 0.5415351 | 0.9426638 | 0.54154 | NA | NA |
| CDKN2A | gefitinib | 0.5418616 | 0.9426638 | 0.54186 | NA | NA |
| BRCA2 | dabrafenib | 0.5419188 | 0.9426638 | 0.54192 | NA | NA |
| FGFR3 | olaparib | 0.5420962 | 0.9426638 | 0.54210 | NA | NA |
| XPO1 | ruxolitinib | 0.5421362 | 0.9426638 | 0.54214 | NA | NA |
| MAP2K2 | cyclophosphamide | 0.5425123 | 0.9426638 | 0.54251 | NA | NA |
| TSC2 | crizotinib | 0.5427013 | 0.9426638 | 0.54270 | NA | NA |
| PTCH1 | fulvestrant | 0.5427377 | 0.9426638 | 0.54274 | NA | NA |
| SF1 | gefitinib | 0.5435458 | 0.9435999 | 0.54355 | NA | NA |
| BRCA2 | cyclophosphamide | 0.5442614 | 0.9439587 | 0.54426 | NA | NA |
| TP53 | vandetanib | 0.5443709 | 0.9439587 | 0.54437 | NA | NA |
| NPM1 | nilotinib | 0.5448245 | 0.9439587 | 0.54482 | NA | NA |
| AR | selumetinib | 0.5450963 | 0.9439587 | 0.54510 | NA | NA |
| SH2B3 | regorafenib | 0.5450991 | 0.9439587 | 0.54510 | NA | NA |
| TET2 | dabrafenib | 0.5455143 | 0.9439718 | 0.54551 | NA | NA |
| AKT3 | crizotinib | 0.5462479 | 0.9439718 | 0.54625 | NA | NA |
| CDK6 | nilotinib | 0.5465693 | 0.9439718 | 0.54657 | NA | NA |
| RPL10 | azd | 0.5472348 | 0.9439718 | 0.54723 | NA | NA |
| EGFR | erlotinib | 0.5472418 | 0.9439718 | 0.54724 | NA | NA |
| EGFR | nilotinib | 0.5479716 | 0.9439718 | 0.54797 | NA | NA |
| ESR1 | regorafenib | 0.5481555 | 0.9439718 | 0.54816 | NA | NA |
| CBL | dasatinib | 0.5483351 | 0.9439718 | 0.54834 | NA | NA |
| TSC2 | erlotinib | 0.5491647 | 0.9439718 | 0.54916 | NA | NA |
| EZH2 | ibrutinib | 0.5491654 | 0.9439718 | 0.54917 | NA | NA |
| AR | vemurafenib | 0.5492099 | 0.9439718 | 0.54921 | NA | NA |
| PAX8 | sunitinib | 0.5497315 | 0.9439718 | 0.54973 | NA | NA |
| RUNX1 | dabrafenib | 0.5500761 | 0.9439718 | 0.55008 | NA | NA |
| ATM | azd | 0.5513285 | 0.9439718 | 0.55133 | NA | NA |
| ERBB3 | selumetinib | 0.5514235 | 0.9439718 | 0.55142 | NA | NA |
| MGMT | azd | 0.5517454 | 0.9439718 | 0.55175 | NA | NA |
| PAX8 | ruxolitinib | 0.5518605 | 0.9439718 | 0.55186 | NA | NA |
| TSC2 | temozolomide | 0.5520727 | 0.9439718 | 0.55207 | NA | NA |
| MYD88 | neratinib | 0.5522299 | 0.9439718 | 0.55223 | NA | NA |
| JAK2 | dabrafenib | 0.5524829 | 0.9439718 | 0.55248 | NA | NA |
| PAX5 | erlotinib | 0.5529821 | 0.9439718 | 0.55298 | NA | NA |
| GNAS | sunitinib | 0.5536865 | 0.9439718 | 0.55369 | NA | NA |
| SMO | temozolomide | 0.5540279 | 0.9439718 | 0.55403 | NA | NA |
| GNA11 | imatinib | 0.5547601 | 0.9439718 | 0.55476 | NA | NA |
| CD274 | azd | 0.5551244 | 0.9439718 | 0.55512 | NA | NA |
| CD79B | fulvestrant | 0.5551558 | 0.9439718 | 0.55516 | NA | NA |
| U2AF1 | temozolomide | 0.5555499 | 0.9439718 | 0.55555 | NA | NA |
| EED | neratinib | 0.5557457 | 0.9439718 | 0.55575 | NA | NA |
| IDH2 | ruxolitinib | 0.5558028 | 0.9439718 | 0.55580 | NA | NA |
| PDGFRB | fulvestrant | 0.5559160 | 0.9439718 | 0.55592 | NA | NA |
| PDGFB | gefitinib | 0.5559298 | 0.9439718 | 0.55593 | NA | NA |
| GATA1 | crizotinib | 0.5559684 | 0.9439718 | 0.55597 | NA | NA |
| JAK1 | dabrafenib | 0.5564198 | 0.9439718 | 0.55642 | NA | NA |
| EED | fluorouracil | 0.5569099 | 0.9439718 | 0.55691 | NA | NA |
| PRPF8 | crizotinib | 0.5571369 | 0.9439718 | 0.55714 | NA | NA |
| SH2B3 | lapatinib | 0.5575143 | 0.9439718 | 0.55751 | NA | NA |
| CTNNB1 | olaparib | 0.5575229 | 0.9439718 | 0.55752 | NA | NA |
| ERBB2 | vemurafenib | 0.5578381 | 0.9439718 | 0.55784 | NA | NA |
| CD79B | pazopanib | 0.5581185 | 0.9439718 | 0.55812 | NA | NA |
| WT1 | azd | 0.5582167 | 0.9439718 | 0.55822 | NA | NA |
| ZRSR2 | vemurafenib | 0.5582444 | 0.9439718 | 0.55824 | NA | NA |
| TET2 | crizotinib | 0.5583494 | 0.9439718 | 0.55835 | NA | NA |
| U2AF1 | erlotinib | 0.5590181 | 0.9439718 | 0.55902 | NA | NA |
| SETD2 | pazopanib | 0.5598273 | 0.9439718 | 0.55983 | NA | NA |
| TSC2 | vandetanib | 0.5599331 | 0.9439718 | 0.55993 | NA | NA |
| SMO | afatinib | 0.5600384 | 0.9439718 | 0.56004 | NA | NA |
| ERBB2 | vandetanib | 0.5606927 | 0.9439718 | 0.56069 | NA | NA |
| SSX1 | belinostat | 0.5609854 | 0.9439718 | 0.56099 | NA | NA |
| STAT3 | nilotinib | 0.5611889 | 0.9439718 | 0.56119 | NA | NA |
| PDGFRB | nilotinib | 0.5622570 | 0.9439718 | 0.56226 | NA | NA |
| MYCN | fluorouracil | 0.5625227 | 0.9439718 | 0.56252 | NA | NA |
| AKT2 | neratinib | 0.5626464 | 0.9439718 | 0.56265 | NA | NA |
| U2AF1 | cyclophosphamide | 0.5627586 | 0.9439718 | 0.56276 | NA | NA |
| IKZF1 | olaparib | 0.5637986 | 0.9439718 | 0.56380 | NA | NA |
| PDCD1 | vandetanib | 0.5638282 | 0.9439718 | 0.56383 | NA | NA |
| NRAS | fluorouracil | 0.5640895 | 0.9439718 | 0.56409 | NA | NA |
| FGFR1 | erlotinib | 0.5641627 | 0.9439718 | 0.56416 | NA | NA |
| DNAJB1 | sunitinib | 0.5641677 | 0.9439718 | 0.56417 | NA | NA |
| IL7R | lapatinib | 0.5643909 | 0.9439718 | 0.56439 | NA | NA |
| CDK6 | fluorouracil | 0.5643997 | 0.9439718 | 0.56440 | NA | NA |
| BCORL1 | selumetinib | 0.5646517 | 0.9439718 | 0.56465 | NA | NA |
| STAT3 | crizotinib | 0.5651302 | 0.9439718 | 0.56513 | NA | NA |
| U2AF1 | cabozantinib | 0.5653347 | 0.9439718 | 0.56533 | NA | NA |
| PAX8 | dabrafenib | 0.5654873 | 0.9439718 | 0.56549 | NA | NA |
| TET2 | fluorouracil | 0.5663106 | 0.9439718 | 0.56631 | NA | NA |
| XPO1 | trametinib | 0.5663317 | 0.9439718 | 0.56633 | NA | NA |
| CTNNB1 | neratinib | 0.5673863 | 0.9439718 | 0.56739 | NA | NA |
| STAT3 | vemurafenib | 0.5675042 | 0.9439718 | 0.56750 | NA | NA |
| MAP2K1 | neratinib | 0.5675322 | 0.9439718 | 0.56753 | NA | NA |
| IL7R | ruxolitinib | 0.5675484 | 0.9439718 | 0.56755 | NA | NA |
| SMO | ruxolitinib | 0.5675527 | 0.9439718 | 0.56755 | NA | NA |
| GNAQ | regorafenib | 0.5675838 | 0.9439718 | 0.56758 | NA | NA |
| GATA2 | dabrafenib | 0.5679266 | 0.9439718 | 0.56793 | NA | NA |
| STAT3 | sunitinib | 0.5679662 | 0.9439718 | 0.56797 | NA | NA |
| CBL | olaparib | 0.5684804 | 0.9439718 | 0.56848 | NA | NA |
| JAK2 | ibrutinib | 0.5688103 | 0.9439718 | 0.56881 | NA | NA |
| RET | fulvestrant | 0.5689282 | 0.9439718 | 0.56893 | NA | NA |
| ZRSR2 | fulvestrant | 0.5690843 | 0.9439718 | 0.56908 | NA | NA |
| BTK | neratinib | 0.5692234 | 0.9439718 | 0.56922 | NA | NA |
| CDKN2A | erlotinib | 0.5693316 | 0.9439718 | 0.56933 | NA | NA |
| NOTCH2 | vemurafenib | 0.5698987 | 0.9439718 | 0.56990 | NA | NA |
| MGMT | olaparib | 0.5699313 | 0.9439718 | 0.56993 | NA | NA |
| SH2B3 | temozolomide | 0.5700519 | 0.9439718 | 0.57005 | NA | NA |
| SMC1A | nilotinib | 0.5706209 | 0.9439718 | 0.57062 | NA | NA |
| PDGFB | olaparib | 0.5706892 | 0.9439718 | 0.57069 | NA | NA |
| MAP2K1 | temozolomide | 0.5710964 | 0.9439718 | 0.57110 | NA | NA |
| GNAQ | cyclophosphamide | 0.5711972 | 0.9439718 | 0.57120 | NA | NA |
| FLT3 | fulvestrant | 0.5722357 | 0.9439718 | 0.57224 | NA | NA |
| MPL | vemurafenib | 0.5734209 | 0.9439718 | 0.57342 | NA | NA |
| NCOA2 | imatinib | 0.5735089 | 0.9439718 | 0.57351 | NA | NA |
| CEBPA | vandetanib | 0.5735805 | 0.9439718 | 0.57358 | NA | NA |
| SH2B3 | trametinib | 0.5743914 | 0.9439718 | 0.57439 | NA | NA |
| U2AF1 | trametinib | 0.5743914 | 0.9439718 | 0.57439 | NA | NA |
| IDH1 | sunitinib | 0.5752268 | 0.9439718 | 0.57523 | NA | NA |
| BCORL1 | crizotinib | 0.5765314 | 0.9439718 | 0.57653 | NA | NA |
| SETD2 | regorafenib | 0.5770596 | 0.9439718 | 0.57706 | NA | NA |
| KRAS | cyclophosphamide | 0.5770737 | 0.9439718 | 0.57707 | NA | NA |
| PML | belinostat | 0.5778444 | 0.9439718 | 0.57784 | NA | NA |
| MAP2K1 | olaparib | 0.5778533 | 0.9439718 | 0.57785 | NA | NA |
| FANCL | olaparib | 0.5779965 | 0.9439718 | 0.57800 | NA | NA |
| PDGFRB | gefitinib | 0.5781143 | 0.9439718 | 0.57811 | NA | NA |
| SH2B3 | fulvestrant | 0.5781176 | 0.9439718 | 0.57812 | NA | NA |
| BCOR | fulvestrant | 0.5781760 | 0.9439718 | 0.57818 | NA | NA |
| DPYD | sunitinib | 0.5784482 | 0.9439718 | 0.57845 | NA | NA |
| SETD2 | cabozantinib | 0.5786852 | 0.9439718 | 0.57869 | NA | NA |
| GNB1 | ruxolitinib | 0.5787520 | 0.9439718 | 0.57875 | NA | NA |
| MYD88 | pazopanib | 0.5788620 | 0.9439718 | 0.57886 | NA | NA |
| PRPF40B | cyclophosphamide | 0.5796414 | 0.9439718 | 0.57964 | NA | NA |
| BTK | ruxolitinib | 0.5797617 | 0.9439718 | 0.57976 | NA | NA |
| MPL | regorafenib | 0.5803078 | 0.9439718 | 0.58031 | NA | NA |
| FANCL | dabrafenib | 0.5804329 | 0.9439718 | 0.58043 | NA | NA |
| RAD21 | sunitinib | 0.5805152 | 0.9439718 | 0.58052 | NA | NA |
| TP53 | ruxolitinib | 0.5806922 | 0.9439718 | 0.58069 | NA | NA |
| WT1 | nilotinib | 0.5807610 | 0.9439718 | 0.58076 | NA | NA |
| SMO | pazopanib | 0.5808466 | 0.9439718 | 0.58085 | NA | NA |
| TP53 | lapatinib | 0.5810293 | 0.9439718 | 0.58103 | NA | NA |
| UGT1A1 | afatinib | 0.5812670 | 0.9439718 | 0.58127 | NA | NA |
| CSF3R | cyclophosphamide | 0.5812996 | 0.9439718 | 0.58130 | NA | NA |
| MAP2K2 | belinostat | 0.5817736 | 0.9439718 | 0.58177 | NA | NA |
| ABL1 | imatinib | 0.5818558 | 0.9439718 | 0.58186 | NA | NA |
| CBL | cyclophosphamide | 0.5820601 | 0.9439718 | 0.58206 | NA | NA |
| JAK3 | nilotinib | 0.5820909 | 0.9439718 | 0.58209 | NA | NA |
| SF3B1 | erlotinib | 0.5821367 | 0.9439718 | 0.58214 | NA | NA |
| FLT3 | imatinib | 0.5821546 | 0.9439718 | 0.58215 | NA | NA |
| CTCF | crizotinib | 0.5823874 | 0.9439718 | 0.58239 | NA | NA |
| GATA3 | olaparib | 0.5824076 | 0.9439718 | 0.58241 | NA | NA |
| ERBB3 | nilotinib | 0.5829246 | 0.9439718 | 0.58292 | NA | NA |
| JAK3 | pazopanib | 0.5834963 | 0.9439718 | 0.58350 | NA | NA |
| FGFR1 | afatinib | 0.5840901 | 0.9439718 | 0.58409 | NA | NA |
| CDK6 | olaparib | 0.5843079 | 0.9439718 | 0.58431 | NA | NA |
| DNMT3A | cyclophosphamide | 0.5843537 | 0.9439718 | 0.58435 | NA | NA |
| BTK | azd | 0.5845687 | 0.9439718 | 0.58457 | NA | NA |
| PHF6 | neratinib | 0.5847037 | 0.9439718 | 0.58470 | NA | NA |
| CALR | dasatinib | 0.5847504 | 0.9439718 | 0.58475 | NA | NA |
| PML | cabozantinib | 0.5847529 | 0.9439718 | 0.58475 | NA | NA |
| PRPF40B | dasatinib | 0.5848789 | 0.9439718 | 0.58488 | NA | NA |
| NOTCH1 | crizotinib | 0.5851495 | 0.9439718 | 0.58515 | NA | NA |
| TP53 | neratinib | 0.5853550 | 0.9439718 | 0.58536 | NA | NA |
| SRSF2 | regorafenib | 0.5854363 | 0.9439718 | 0.58544 | NA | NA |
| WT1 | cyclophosphamide | 0.5856825 | 0.9439718 | 0.58568 | NA | NA |
| GATA3 | neratinib | 0.5858586 | 0.9439718 | 0.58586 | NA | NA |
| SETD2 | sunitinib | 0.5862419 | 0.9439718 | 0.58624 | NA | NA |
| EML4 | gefitinib | 0.5864377 | 0.9439718 | 0.58644 | NA | NA |
| TET2 | neratinib | 0.5867138 | 0.9439718 | 0.58671 | NA | NA |
| AKT3 | azd | 0.5867560 | 0.9439718 | 0.58676 | NA | NA |
| RAD21 | crizotinib | 0.5870720 | 0.9439718 | 0.58707 | NA | NA |
| CXCR4 | selumetinib | 0.5872055 | 0.9439718 | 0.58721 | NA | NA |
| GATA1 | fluorouracil | 0.5872632 | 0.9439718 | 0.58726 | NA | NA |
| ZRSR2 | crizotinib | 0.5873715 | 0.9439718 | 0.58737 | NA | NA |
| MPL | vandetanib | 0.5876287 | 0.9439718 | 0.58763 | NA | NA |
| SMC3 | lapatinib | 0.5876365 | 0.9439718 | 0.58764 | NA | NA |
| ROS1 | belinostat | 0.5877641 | 0.9439718 | 0.58776 | NA | NA |
| FGFR1 | ibrutinib | 0.5881332 | 0.9439718 | 0.58813 | NA | NA |
| AKT1 | temozolomide | 0.5884213 | 0.9439718 | 0.58842 | NA | NA |
| KIT | lapatinib | 0.5885275 | 0.9439718 | 0.58853 | NA | NA |
| CTNNB1 | cabozantinib | 0.5892427 | 0.9439718 | 0.58924 | NA | NA |
| GNB1 | erlotinib | 0.5892431 | 0.9439718 | 0.58924 | NA | NA |
| MAP2K1 | fluorouracil | 0.5893340 | 0.9439718 | 0.58933 | NA | NA |
| NCOA2 | gefitinib | 0.5894485 | 0.9439718 | 0.58945 | NA | NA |
| ERBB3 | fulvestrant | 0.5897197 | 0.9439718 | 0.58972 | NA | NA |
| CREBBP | dabrafenib | 0.5898748 | 0.9439718 | 0.58987 | NA | NA |
| STAT3 | neratinib | 0.5899191 | 0.9439718 | 0.58992 | NA | NA |
| IL7R | erlotinib | 0.5900249 | 0.9439718 | 0.59002 | NA | NA |
| MDM2 | erlotinib | 0.5904307 | 0.9439718 | 0.59043 | NA | NA |
| PIGA | ibrutinib | 0.5914515 | 0.9439718 | 0.59145 | NA | NA |
| CREBBP | temozolomide | 0.5922228 | 0.9439718 | 0.59222 | NA | NA |
| SF1 | ibrutinib | 0.5922909 | 0.9439718 | 0.59229 | NA | NA |
| NOTCH1 | imatinib | 0.5925381 | 0.9439718 | 0.59254 | NA | NA |
| AR | afatinib | 0.5928043 | 0.9439718 | 0.59280 | NA | NA |
| KIT | azd | 0.5928965 | 0.9439718 | 0.59290 | NA | NA |
| PTEN | fulvestrant | 0.5928983 | 0.9439718 | 0.59290 | NA | NA |
| CD274 | dasatinib | 0.5930913 | 0.9439718 | 0.59309 | NA | NA |
| NCOA2 | ruxolitinib | 0.5931302 | 0.9439718 | 0.59313 | NA | NA |
| BTK | trametinib | 0.5932755 | 0.9439718 | 0.59328 | NA | NA |
| JAK1 | belinostat | 0.5933111 | 0.9439718 | 0.59331 | NA | NA |
| CRLF2 | dasatinib | 0.5935835 | 0.9439718 | 0.59358 | NA | NA |
| TET2 | vandetanib | 0.5936187 | 0.9439718 | 0.59362 | NA | NA |
| ASXL1 | crizotinib | 0.5936541 | 0.9439718 | 0.59365 | NA | NA |
| IKZF1 | erlotinib | 0.5937279 | 0.9439718 | 0.59373 | NA | NA |
| EED | vemurafenib | 0.5938903 | 0.9439718 | 0.59389 | NA | NA |
| GATA1 | selumetinib | 0.5940691 | 0.9439718 | 0.59407 | NA | NA |
| NOTCH1 | trametinib | 0.5941232 | 0.9439718 | 0.59412 | NA | NA |
| PDGFRB | temozolomide | 0.5946643 | 0.9444034 | 0.59466 | NA | NA |
| PAX5 | sunitinib | 0.5950463 | 0.9445821 | 0.59505 | NA | NA |
| SF1 | lapatinib | 0.5955219 | 0.9449092 | 0.59552 | NA | NA |
| FGFR1 | nilotinib | 0.5959299 | 0.9451287 | 0.59593 | NA | NA |
| PRPF40B | vemurafenib | 0.5974261 | 0.9470731 | 0.59743 | NA | NA |
| PIGA | selumetinib | 0.5988009 | 0.9476659 | 0.59880 | NA | NA |
| NRAS | dabrafenib | 0.5989560 | 0.9476659 | 0.59896 | NA | NA |
| DPYD | cabozantinib | 0.5989674 | 0.9476659 | 0.59897 | NA | NA |
| GATA1 | afatinib | 0.5992718 | 0.9476659 | 0.59927 | NA | NA |
| PAX5 | selumetinib | 0.5992871 | 0.9476659 | 0.59929 | NA | NA |
| ATM | nilotinib | 0.5994224 | 0.9476659 | 0.59942 | NA | NA |
| EML4 | azd | 0.6000011 | 0.9479822 | 0.60000 | NA | NA |
| CTLA4 | nilotinib | 0.6001633 | 0.9479822 | 0.60016 | NA | NA |
| NT5C2 | ibrutinib | 0.6005938 | 0.9482348 | 0.60059 | NA | NA |
| ERBB4 | cyclophosphamide | 0.6013206 | 0.9484578 | 0.60132 | NA | NA |
| SF1 | ruxolitinib | 0.6017314 | 0.9484578 | 0.60173 | NA | NA |
| CD274 | lapatinib | 0.6020040 | 0.9484578 | 0.60200 | NA | NA |
| NT5C2 | fulvestrant | 0.6021476 | 0.9484578 | 0.60215 | NA | NA |
| TET2 | belinostat | 0.6023459 | 0.9484578 | 0.60235 | NA | NA |
| G6PD | ibrutinib | 0.6023586 | 0.9484578 | 0.60236 | NA | NA |
| STAT3 | cyclophosphamide | 0.6028017 | 0.9485153 | 0.60280 | NA | NA |
| RUNX1 | lapatinib | 0.6029364 | 0.9485153 | 0.60294 | NA | NA |
| PIGA | vandetanib | 0.6041903 | 0.9491582 | 0.60419 | NA | NA |
| HRAS | nilotinib | 0.6043473 | 0.9491582 | 0.60435 | NA | NA |
| SH2B3 | cyclophosphamide | 0.6046266 | 0.9491582 | 0.60463 | NA | NA |
| JAK1 | trametinib | 0.6047835 | 0.9491582 | 0.60478 | NA | NA |
| XPO1 | neratinib | 0.6049084 | 0.9491582 | 0.60491 | NA | NA |
| XPO1 | azd | 0.6049699 | 0.9491582 | 0.60497 | NA | NA |
| DNMT3A | vemurafenib | 0.6061305 | 0.9496346 | 0.60613 | NA | NA |
| PDCD1 | ibrutinib | 0.6070878 | 0.9496346 | 0.60709 | NA | NA |
| MET | azd | 0.6072926 | 0.9496346 | 0.60729 | NA | NA |
| DNAJB1 | belinostat | 0.6075884 | 0.9496346 | 0.60759 | NA | NA |
| MAP2K1 | vandetanib | 0.6076938 | 0.9496346 | 0.60769 | NA | NA |
| GNA11 | sunitinib | 0.6077823 | 0.9496346 | 0.60778 | NA | NA |
| VHL | ibrutinib | 0.6081955 | 0.9496346 | 0.60820 | NA | NA |
| G6PD | azd | 0.6083192 | 0.9496346 | 0.60832 | NA | NA |
| STAG2 | ruxolitinib | 0.6085848 | 0.9496346 | 0.60858 | NA | NA |
| MGMT | cyclophosphamide | 0.6089169 | 0.9496346 | 0.60892 | NA | NA |
| RET | cabozantinib | 0.6089852 | 0.9496346 | 0.60899 | NA | NA |
| NT5C2 | selumetinib | 0.6090924 | 0.9496346 | 0.60909 | NA | NA |
| BCOR | pazopanib | 0.6091276 | 0.9496346 | 0.60913 | NA | NA |
| SMC3 | regorafenib | 0.6092466 | 0.9496346 | 0.60925 | NA | NA |
| ERBB4 | belinostat | 0.6093376 | 0.9496346 | 0.60934 | NA | NA |
| CD274 | afatinib | 0.6100780 | 0.9500645 | 0.61008 | NA | NA |
| MAP2K1 | imatinib | 0.6104410 | 0.9500645 | 0.61044 | NA | NA |
| CDKN2A | neratinib | 0.6104631 | 0.9500645 | 0.61046 | NA | NA |
| BCORL1 | olaparib | 0.6106976 | 0.9500645 | 0.61070 | NA | NA |
| TET2 | vemurafenib | 0.6113322 | 0.9505542 | 0.61133 | NA | NA |
| VHL | ruxolitinib | 0.6115548 | 0.9505542 | 0.61155 | NA | NA |
| WT1 | selumetinib | 0.6124498 | 0.9508415 | 0.61245 | NA | NA |
| PDGFB | erlotinib | 0.6129494 | 0.9508415 | 0.61295 | NA | NA |
| GATA2 | regorafenib | 0.6133776 | 0.9508415 | 0.61338 | NA | NA |
| IL7R | vemurafenib | 0.6141559 | 0.9508415 | 0.61416 | NA | NA |
| PHF6 | selumetinib | 0.6145065 | 0.9508415 | 0.61451 | NA | NA |
| SSX1 | erlotinib | 0.6145493 | 0.9508415 | 0.61455 | NA | NA |
| WT1 | afatinib | 0.6146663 | 0.9508415 | 0.61467 | NA | NA |
| PAX8 | afatinib | 0.6146819 | 0.9508415 | 0.61468 | NA | NA |
| BCOR | azd | 0.6149811 | 0.9508415 | 0.61498 | NA | NA |
| PAX5 | nilotinib | 0.6150802 | 0.9508415 | 0.61508 | NA | NA |
| BCORL1 | neratinib | 0.6156018 | 0.9508415 | 0.61560 | NA | NA |
| KMT2A | selumetinib | 0.6156370 | 0.9508415 | 0.61564 | NA | NA |
| XPO1 | belinostat | 0.6157812 | 0.9508415 | 0.61578 | NA | NA |
| ZRSR2 | fluorouracil | 0.6160040 | 0.9508415 | 0.61600 | NA | NA |
| PAX5 | cyclophosphamide | 0.6160580 | 0.9508415 | 0.61606 | NA | NA |
| PTPN11 | crizotinib | 0.6160802 | 0.9508415 | 0.61608 | NA | NA |
| MYD88 | ruxolitinib | 0.6181728 | 0.9516061 | 0.61817 | NA | NA |
| ABL1 | nilotinib | 0.6182260 | 0.9516061 | 0.61823 | NA | NA |
| CYP19A1 | vandetanib | 0.6183456 | 0.9516061 | 0.61835 | NA | NA |
| TSC1 | trametinib | 0.6186725 | 0.9516061 | 0.61867 | NA | NA |
| NT5C2 | pazopanib | 0.6188891 | 0.9516061 | 0.61889 | NA | NA |
| PIGA | temozolomide | 0.6192551 | 0.9516061 | 0.61926 | NA | NA |
| PTPN11 | nilotinib | 0.6193257 | 0.9516061 | 0.61933 | NA | NA |
| SF1 | selumetinib | 0.6193720 | 0.9516061 | 0.61937 | NA | NA |
| ERBB2 | temozolomide | 0.6194974 | 0.9516061 | 0.61950 | NA | NA |
| PDGFRB | vemurafenib | 0.6197336 | 0.9516061 | 0.61973 | NA | NA |
| TSC1 | olaparib | 0.6197994 | 0.9516061 | 0.61980 | NA | NA |
| PHF6 | gefitinib | 0.6199449 | 0.9516061 | 0.61994 | NA | NA |
| STAG2 | cabozantinib | 0.6204197 | 0.9516061 | 0.62042 | NA | NA |
| AR | temozolomide | 0.6204683 | 0.9516061 | 0.62047 | NA | NA |
| CTNNB1 | fluorouracil | 0.6209367 | 0.9516061 | 0.62094 | NA | NA |
| BRCA1 | pazopanib | 0.6211989 | 0.9516061 | 0.62120 | NA | NA |
| PDGFRA | dabrafenib | 0.6212605 | 0.9516061 | 0.62126 | NA | NA |
| BRCA1 | dasatinib | 0.6214626 | 0.9516061 | 0.62146 | NA | NA |
| CDK4 | pazopanib | 0.6220277 | 0.9516656 | 0.62203 | NA | NA |
| NPM1 | ruxolitinib | 0.6223011 | 0.9516656 | 0.62230 | NA | NA |
| FBXW7 | lapatinib | 0.6223969 | 0.9516656 | 0.62240 | NA | NA |
| SMC1A | temozolomide | 0.6228976 | 0.9516656 | 0.62290 | NA | NA |
| GNAQ | selumetinib | 0.6231521 | 0.9516656 | 0.62315 | NA | NA |
| FBXW7 | belinostat | 0.6233860 | 0.9516656 | 0.62339 | NA | NA |
| SH2B3 | pazopanib | 0.6234996 | 0.9516656 | 0.62350 | NA | NA |
| FGFR2 | selumetinib | 0.6236736 | 0.9516656 | 0.62367 | NA | NA |
| TET2 | trametinib | 0.6245492 | 0.9519685 | 0.62455 | NA | NA |
| CDC73 | selumetinib | 0.6247346 | 0.9519685 | 0.62473 | NA | NA |
| NT5C2 | vandetanib | 0.6247551 | 0.9519685 | 0.62476 | NA | NA |
| CALR | erlotinib | 0.6249585 | 0.9519685 | 0.62496 | NA | NA |
| SRSF2 | fulvestrant | 0.6257755 | 0.9524460 | 0.62578 | NA | NA |
| TSC2 | lapatinib | 0.6258155 | 0.9524460 | 0.62582 | NA | NA |
| SF3B1 | belinostat | 0.6263425 | 0.9528345 | 0.62634 | NA | NA |
| CD79B | erlotinib | 0.6268979 | 0.9529676 | 0.62690 | NA | NA |
| CYP19A1 | ruxolitinib | 0.6276320 | 0.9529676 | 0.62763 | NA | NA |
| AKT2 | afatinib | 0.6279052 | 0.9529676 | 0.62791 | NA | NA |
| PIK3CA | azd | 0.6282066 | 0.9529676 | 0.62821 | NA | NA |
| SF1 | dabrafenib | 0.6289304 | 0.9529676 | 0.62893 | NA | NA |
| IDH1 | temozolomide | 0.6290971 | 0.9529676 | 0.62910 | NA | NA |
| ERBB2 | ruxolitinib | 0.6293981 | 0.9529676 | 0.62940 | NA | NA |
| ATM | imatinib | 0.6294816 | 0.9529676 | 0.62948 | NA | NA |
| PRPF8 | pazopanib | 0.6300675 | 0.9529676 | 0.63007 | NA | NA |
| DNMT3A | ruxolitinib | 0.6300700 | 0.9529676 | 0.63007 | NA | NA |
| MYCN | selumetinib | 0.6303901 | 0.9529676 | 0.63039 | NA | NA |
| ATM | erlotinib | 0.6305159 | 0.9529676 | 0.63052 | NA | NA |
| KIT | vandetanib | 0.6306055 | 0.9529676 | 0.63061 | NA | NA |
| IDH1 | dasatinib | 0.6308254 | 0.9529676 | 0.63083 | NA | NA |
| AKT1 | regorafenib | 0.6309258 | 0.9529676 | 0.63093 | NA | NA |
| AKT1 | fluorouracil | 0.6312805 | 0.9529676 | 0.63128 | NA | NA |
| RET | imatinib | 0.6313687 | 0.9529676 | 0.63137 | NA | NA |
| IKZF1 | nilotinib | 0.6314605 | 0.9529676 | 0.63146 | NA | NA |
| FGFR2 | cabozantinib | 0.6315959 | 0.9529676 | 0.63160 | NA | NA |
| CBLB | vandetanib | 0.6330509 | 0.9544571 | 0.63305 | NA | NA |
| MYCN | vemurafenib | 0.6331278 | 0.9544571 | 0.63313 | NA | NA |
| CEBPA | afatinib | 0.6336638 | 0.9548545 | 0.63366 | NA | NA |
| SF1 | nilotinib | 0.6341439 | 0.9550146 | 0.63414 | NA | NA |
| CDK6 | afatinib | 0.6345662 | 0.9550146 | 0.63457 | NA | NA |
| RAD21 | afatinib | 0.6348632 | 0.9550146 | 0.63486 | NA | NA |
| CDKN2A | dabrafenib | 0.6348974 | 0.9550146 | 0.63490 | NA | NA |
| STAT3 | belinostat | 0.6351324 | 0.9550146 | 0.63513 | NA | NA |
| ESR1 | azd | 0.6359850 | 0.9554147 | 0.63598 | NA | NA |
| IDH2 | crizotinib | 0.6363824 | 0.9554147 | 0.63638 | NA | NA |
| TSC1 | erlotinib | 0.6364596 | 0.9554147 | 0.63646 | NA | NA |
| RUNX1 | olaparib | 0.6364888 | 0.9554147 | 0.63649 | NA | NA |
| FANCL | selumetinib | 0.6382296 | 0.9566868 | 0.63823 | NA | NA |
| MPL | fulvestrant | 0.6382741 | 0.9566868 | 0.63827 | NA | NA |
| TP53 | erlotinib | 0.6385136 | 0.9566868 | 0.63851 | NA | NA |
| CDC73 | neratinib | 0.6391371 | 0.9566868 | 0.63914 | NA | NA |
| STAT3 | ruxolitinib | 0.6391463 | 0.9566868 | 0.63915 | NA | NA |
| CBLB | ibrutinib | 0.6394929 | 0.9566868 | 0.63949 | NA | NA |
| AKT2 | fulvestrant | 0.6395519 | 0.9566868 | 0.63955 | NA | NA |
| STAG2 | trametinib | 0.6396032 | 0.9566868 | 0.63960 | NA | NA |
| ERBB3 | gefitinib | 0.6397928 | 0.9566868 | 0.63979 | NA | NA |
| CDKN2A | belinostat | 0.6401072 | 0.9567487 | 0.64011 | NA | NA |
| EML4 | nilotinib | 0.6404142 | 0.9567995 | 0.64041 | NA | NA |
| GNB1 | nilotinib | 0.6407151 | 0.9568413 | 0.64072 | NA | NA |
| EED | dasatinib | 0.6413131 | 0.9573264 | 0.64131 | NA | NA |
| TSC1 | crizotinib | 0.6420105 | 0.9575859 | 0.64201 | NA | NA |
| AKT3 | ruxolitinib | 0.6421902 | 0.9575859 | 0.64219 | NA | NA |
| GATA1 | nilotinib | 0.6426001 | 0.9575859 | 0.64260 | NA | NA |
| VHL | neratinib | 0.6428242 | 0.9575859 | 0.64282 | NA | NA |
| KIT | imatinib | 0.6429646 | 0.9575859 | 0.64296 | NA | NA |
| KMT2A | azd | 0.6439413 | 0.9575859 | 0.64394 | NA | NA |
| AKT1 | pazopanib | 0.6440994 | 0.9575859 | 0.64410 | NA | NA |
| CREBBP | imatinib | 0.6443870 | 0.9575859 | 0.64439 | NA | NA |
| PDGFB | selumetinib | 0.6445370 | 0.9575859 | 0.64454 | NA | NA |
| CTLA4 | pazopanib | 0.6447774 | 0.9575859 | 0.64478 | NA | NA |
| FGFR2 | neratinib | 0.6455024 | 0.9575859 | 0.64550 | NA | NA |
| SH2B3 | gefitinib | 0.6455532 | 0.9575859 | 0.64555 | NA | NA |
| MET | erlotinib | 0.6459851 | 0.9575859 | 0.64599 | NA | NA |
| GNA11 | dasatinib | 0.6462779 | 0.9575859 | 0.64628 | NA | NA |
| FGFR1 | fulvestrant | 0.6465440 | 0.9575859 | 0.64654 | NA | NA |
| SF1 | erlotinib | 0.6467566 | 0.9575859 | 0.64676 | NA | NA |
| HRAS | erlotinib | 0.6468475 | 0.9575859 | 0.64685 | NA | NA |
| ERBB4 | azd | 0.6472118 | 0.9575859 | 0.64721 | NA | NA |
| FGFR1 | dasatinib | 0.6473080 | 0.9575859 | 0.64731 | NA | NA |
| CTCF | temozolomide | 0.6475611 | 0.9575859 | 0.64756 | NA | NA |
| ZRSR2 | azd | 0.6480221 | 0.9575859 | 0.64802 | NA | NA |
| CD274 | imatinib | 0.6480891 | 0.9575859 | 0.64809 | NA | NA |
| EED | belinostat | 0.6481198 | 0.9575859 | 0.64812 | NA | NA |
| BRCA1 | selumetinib | 0.6484298 | 0.9575859 | 0.64843 | NA | NA |
| MAP2K2 | temozolomide | 0.6485561 | 0.9575859 | 0.64856 | NA | NA |
| BTK | olaparib | 0.6485903 | 0.9575859 | 0.64859 | NA | NA |
| SETD2 | azd | 0.6491235 | 0.9579697 | 0.64912 | NA | NA |
| PRPF8 | gefitinib | 0.6498661 | 0.9586619 | 0.64987 | NA | NA |
| ETV6 | fulvestrant | 0.6504248 | 0.9590303 | 0.65042 | NA | NA |
| SH2B3 | selumetinib | 0.6506631 | 0.9590303 | 0.65066 | NA | NA |
| SRSF2 | gefitinib | 0.6512892 | 0.9594723 | 0.65129 | NA | NA |
| PDGFRA | afatinib | 0.6518163 | 0.9594723 | 0.65182 | NA | NA |
| ETV6 | vemurafenib | 0.6520198 | 0.9594723 | 0.65202 | NA | NA |
| GATA1 | imatinib | 0.6521039 | 0.9594723 | 0.65210 | NA | NA |
| JAK3 | ruxolitinib | 0.6523983 | 0.9594723 | 0.65240 | NA | NA |
| GNA11 | selumetinib | 0.6526054 | 0.9594723 | 0.65261 | NA | NA |
| SH2B3 | sunitinib | 0.6528930 | 0.9594926 | 0.65289 | NA | NA |
| ASXL1 | imatinib | 0.6532854 | 0.9595107 | 0.65329 | NA | NA |
| FGFR3 | vandetanib | 0.6537638 | 0.9595107 | 0.65376 | NA | NA |
| ETV6 | dabrafenib | 0.6549022 | 0.9595107 | 0.65490 | NA | NA |
| CBL | fulvestrant | 0.6549564 | 0.9595107 | 0.65496 | NA | NA |
| DNMT3A | azd | 0.6551284 | 0.9595107 | 0.65513 | NA | NA |
| MYD88 | fluorouracil | 0.6552215 | 0.9595107 | 0.65522 | NA | NA |
| IDH2 | cyclophosphamide | 0.6554963 | 0.9595107 | 0.65550 | NA | NA |
| ETV6 | gefitinib | 0.6555992 | 0.9595107 | 0.65560 | NA | NA |
| TP53 | cyclophosphamide | 0.6558587 | 0.9595107 | 0.65586 | NA | NA |
| WHSC1 | ibrutinib | 0.6566414 | 0.9595107 | 0.65664 | NA | NA |
| GNAS | ruxolitinib | 0.6567053 | 0.9595107 | 0.65671 | NA | NA |
| MYCN | olaparib | 0.6570819 | 0.9595107 | 0.65708 | NA | NA |
| U2AF1 | ibrutinib | 0.6570900 | 0.9595107 | 0.65709 | NA | NA |
| IL7R | dasatinib | 0.6571031 | 0.9595107 | 0.65710 | NA | NA |
| CDK4 | erlotinib | 0.6574186 | 0.9595107 | 0.65742 | NA | NA |
| PRPF8 | ruxolitinib | 0.6575194 | 0.9595107 | 0.65752 | NA | NA |
| CBL | neratinib | 0.6577751 | 0.9595107 | 0.65778 | NA | NA |
| PTPN11 | cabozantinib | 0.6578329 | 0.9595107 | 0.65783 | NA | NA |
| BTK | cabozantinib | 0.6581138 | 0.9595211 | 0.65811 | NA | NA |
| UGT1A1 | neratinib | 0.6590084 | 0.9603542 | 0.65901 | NA | NA |
| CDC73 | fluorouracil | 0.6592558 | 0.9603542 | 0.65926 | NA | NA |
| PAX5 | neratinib | 0.6597538 | 0.9603542 | 0.65975 | NA | NA |
| WHSC1 | olaparib | 0.6602208 | 0.9603542 | 0.66022 | NA | NA |
| BRCA2 | ibrutinib | 0.6602730 | 0.9603542 | 0.66027 | NA | NA |
| PTCH1 | belinostat | 0.6603291 | 0.9603542 | 0.66033 | NA | NA |
| CTCF | olaparib | 0.6614206 | 0.9605459 | 0.66142 | NA | NA |
| RPL10 | fluorouracil | 0.6614232 | 0.9605459 | 0.66142 | NA | NA |
| UGT1A1 | lapatinib | 0.6619661 | 0.9605459 | 0.66197 | NA | NA |
| TP53 | ibrutinib | 0.6620836 | 0.9605459 | 0.66208 | NA | NA |
| TSC1 | pazopanib | 0.6622597 | 0.9605459 | 0.66226 | NA | NA |
| GATA3 | pazopanib | 0.6623315 | 0.9605459 | 0.66233 | NA | NA |
| FLCN | lapatinib | 0.6627773 | 0.9605459 | 0.66278 | NA | NA |
| BRAF | regorafenib | 0.6631522 | 0.9605459 | 0.66315 | NA | NA |
| EML4 | erlotinib | 0.6633749 | 0.9605459 | 0.66337 | NA | NA |
| KMT2A | ibrutinib | 0.6634099 | 0.9605459 | 0.66341 | NA | NA |
| SRSF2 | fluorouracil | 0.6636437 | 0.9605459 | 0.66364 | NA | NA |
| ERBB4 | selumetinib | 0.6645769 | 0.9605459 | 0.66458 | NA | NA |
| AKT1 | dasatinib | 0.6650170 | 0.9605459 | 0.66502 | NA | NA |
| IL7R | nilotinib | 0.6653695 | 0.9605459 | 0.66537 | NA | NA |
| ALK | belinostat | 0.6654501 | 0.9605459 | 0.66545 | NA | NA |
| G6PD | afatinib | 0.6656317 | 0.9605459 | 0.66563 | NA | NA |
| RIT1 | fluorouracil | 0.6659043 | 0.9605459 | 0.66590 | NA | NA |
| FANCL | cyclophosphamide | 0.6659245 | 0.9605459 | 0.66592 | NA | NA |
| PDGFRA | fulvestrant | 0.6659409 | 0.9605459 | 0.66594 | NA | NA |
| PML | dabrafenib | 0.6659420 | 0.9605459 | 0.66594 | NA | NA |
| RET | nilotinib | 0.6667141 | 0.9609952 | 0.66671 | NA | NA |
| GATA3 | selumetinib | 0.6669457 | 0.9609952 | 0.66695 | NA | NA |
| GNA11 | erlotinib | 0.6670760 | 0.9609952 | 0.66708 | NA | NA |
| FLCN | pazopanib | 0.6675138 | 0.9612308 | 0.66751 | NA | NA |
| PIK3CA | selumetinib | 0.6680841 | 0.9613655 | 0.66808 | NA | NA |
| SMC3 | fluorouracil | 0.6682697 | 0.9613655 | 0.66827 | NA | NA |
| ASXL1 | ibrutinib | 0.6684302 | 0.9613655 | 0.66843 | NA | NA |
| STAG2 | lapatinib | 0.6687079 | 0.9613705 | 0.66871 | NA | NA |
| GNA11 | temozolomide | 0.6695427 | 0.9615461 | 0.66954 | NA | NA |
| WHSC1 | pazopanib | 0.6699016 | 0.9615461 | 0.66990 | NA | NA |
| RUNX1 | fluorouracil | 0.6701763 | 0.9615461 | 0.67018 | NA | NA |
| ERBB4 | lapatinib | 0.6703606 | 0.9615461 | 0.67036 | NA | NA |
| CDC73 | trametinib | 0.6705477 | 0.9615461 | 0.67055 | NA | NA |
| PTPN11 | fulvestrant | 0.6706631 | 0.9615461 | 0.67066 | NA | NA |
| SSX1 | regorafenib | 0.6710825 | 0.9615461 | 0.67108 | NA | NA |
| SF3B1 | imatinib | 0.6715539 | 0.9615461 | 0.67155 | NA | NA |
| BRCA2 | lapatinib | 0.6720665 | 0.9615461 | 0.67207 | NA | NA |
| PHF6 | ruxolitinib | 0.6723384 | 0.9615461 | 0.67234 | NA | NA |
| MAP2K1 | gefitinib | 0.6726641 | 0.9615461 | 0.67266 | NA | NA |
| NPM1 | cyclophosphamide | 0.6729128 | 0.9615461 | 0.67291 | NA | NA |
| SETBP1 | sunitinib | 0.6730323 | 0.9615461 | 0.67303 | NA | NA |
| FGFR1 | belinostat | 0.6733402 | 0.9615461 | 0.67334 | NA | NA |
| SETD2 | vemurafenib | 0.6735530 | 0.9615461 | 0.67355 | NA | NA |
| GNA11 | olaparib | 0.6738118 | 0.9615461 | 0.67381 | NA | NA |
| G6PD | fulvestrant | 0.6741823 | 0.9615461 | 0.67418 | NA | NA |
| PRPF40B | erlotinib | 0.6742007 | 0.9615461 | 0.67420 | NA | NA |
| PDGFRB | crizotinib | 0.6743149 | 0.9615461 | 0.67431 | NA | NA |
| CTCF | sunitinib | 0.6748162 | 0.9615461 | 0.67482 | NA | NA |
| ESR1 | fulvestrant | 0.6748204 | 0.9615461 | 0.67482 | NA | NA |
| SETBP1 | cyclophosphamide | 0.6751023 | 0.9615461 | 0.67510 | NA | NA |
| BTK | nilotinib | 0.6754528 | 0.9615461 | 0.67545 | NA | NA |
| SF1 | afatinib | 0.6755844 | 0.9615461 | 0.67558 | NA | NA |
| AR | crizotinib | 0.6756885 | 0.9615461 | 0.67569 | NA | NA |
| GNA11 | gefitinib | 0.6764782 | 0.9616758 | 0.67648 | NA | NA |
| AKT2 | vandetanib | 0.6765120 | 0.9616758 | 0.67651 | NA | NA |
| ATM | selumetinib | 0.6766027 | 0.9616758 | 0.67660 | NA | NA |
| KIT | olaparib | 0.6772410 | 0.9621604 | 0.67724 | NA | NA |
| ESR1 | neratinib | 0.6776713 | 0.9621604 | 0.67767 | NA | NA |
| PTCH1 | dabrafenib | 0.6781405 | 0.9621604 | 0.67814 | NA | NA |
| ABL1 | azd | 0.6783940 | 0.9621604 | 0.67839 | NA | NA |
| SMC3 | imatinib | 0.6786729 | 0.9621604 | 0.67867 | NA | NA |
| MDM2 | vandetanib | 0.6793257 | 0.9621604 | 0.67933 | NA | NA |
| PRPF8 | neratinib | 0.6793499 | 0.9621604 | 0.67935 | NA | NA |
| ABL1 | olaparib | 0.6795493 | 0.9621604 | 0.67955 | NA | NA |
| STAG2 | belinostat | 0.6797321 | 0.9621604 | 0.67973 | NA | NA |
| EGFR | cabozantinib | 0.6800714 | 0.9621604 | 0.68007 | NA | NA |
| HRAS | selumetinib | 0.6810792 | 0.9621604 | 0.68108 | NA | NA |
| PAX5 | regorafenib | 0.6816533 | 0.9621604 | 0.68165 | NA | NA |
| MDM2 | fulvestrant | 0.6817076 | 0.9621604 | 0.68171 | NA | NA |
| CBL | selumetinib | 0.6817460 | 0.9621604 | 0.68175 | NA | NA |
| SF3B1 | sunitinib | 0.6819577 | 0.9621604 | 0.68196 | NA | NA |
| RAD21 | vandetanib | 0.6820722 | 0.9621604 | 0.68207 | NA | NA |
| ALK | ruxolitinib | 0.6822022 | 0.9621604 | 0.68220 | NA | NA |
| UGT1A1 | gefitinib | 0.6824391 | 0.9621604 | 0.68244 | NA | NA |
| CD79B | nilotinib | 0.6828744 | 0.9621604 | 0.68287 | NA | NA |
| NRAS | afatinib | 0.6831020 | 0.9621604 | 0.68310 | NA | NA |
| STAT3 | fulvestrant | 0.6831760 | 0.9621604 | 0.68318 | NA | NA |
| ABL1 | vandetanib | 0.6832739 | 0.9621604 | 0.68327 | NA | NA |
| NOTCH2 | cyclophosphamide | 0.6845577 | 0.9621604 | 0.68456 | NA | NA |
| EED | nilotinib | 0.6849533 | 0.9621604 | 0.68495 | NA | NA |
| SETD2 | lapatinib | 0.6852281 | 0.9621604 | 0.68523 | NA | NA |
| GATA1 | belinostat | 0.6853817 | 0.9621604 | 0.68538 | NA | NA |
| FANCL | afatinib | 0.6853991 | 0.9621604 | 0.68540 | NA | NA |
| GNAS | afatinib | 0.6859032 | 0.9621604 | 0.68590 | NA | NA |
| FBXW7 | ruxolitinib | 0.6859258 | 0.9621604 | 0.68593 | NA | NA |
| JAK3 | cabozantinib | 0.6866155 | 0.9621604 | 0.68662 | NA | NA |
| SMC3 | crizotinib | 0.6867765 | 0.9621604 | 0.68678 | NA | NA |
| SMC1A | azd | 0.6870170 | 0.9621604 | 0.68702 | NA | NA |
| CDC73 | dasatinib | 0.6870471 | 0.9621604 | 0.68705 | NA | NA |
| EML4 | crizotinib | 0.6871346 | 0.9621604 | 0.68713 | NA | NA |
| TSC1 | fulvestrant | 0.6874271 | 0.9621604 | 0.68743 | NA | NA |
| PDCD1 | trametinib | 0.6874801 | 0.9621604 | 0.68748 | NA | NA |
| SH2B3 | dasatinib | 0.6879694 | 0.9621604 | 0.68797 | NA | NA |
| CREBBP | selumetinib | 0.6881315 | 0.9621604 | 0.68813 | NA | NA |
| EGF | fulvestrant | 0.6882567 | 0.9621604 | 0.68826 | NA | NA |
| SSX1 | afatinib | 0.6883730 | 0.9621604 | 0.68837 | NA | NA |
| CD274 | erlotinib | 0.6886269 | 0.9621604 | 0.68863 | NA | NA |
| PTCH1 | fluorouracil | 0.6889362 | 0.9621604 | 0.68894 | NA | NA |
| AKT2 | nilotinib | 0.6891592 | 0.9621604 | 0.68916 | NA | NA |
| PTCH1 | crizotinib | 0.6896847 | 0.9621604 | 0.68968 | NA | NA |
| CEBPA | regorafenib | 0.6901052 | 0.9621604 | 0.69011 | NA | NA |
| FGFR1 | temozolomide | 0.6911917 | 0.9621604 | 0.69119 | NA | NA |
| GNB1 | neratinib | 0.6912264 | 0.9621604 | 0.69123 | NA | NA |
| ERBB2 | belinostat | 0.6914232 | 0.9621604 | 0.69142 | NA | NA |
| CYP19A1 | afatinib | 0.6916918 | 0.9621604 | 0.69169 | NA | NA |
| JAK1 | fluorouracil | 0.6918220 | 0.9621604 | 0.69182 | NA | NA |
| ASXL1 | olaparib | 0.6918228 | 0.9621604 | 0.69182 | NA | NA |
| RPL10 | gefitinib | 0.6920568 | 0.9621604 | 0.69206 | NA | NA |
| WHSC1 | vemurafenib | 0.6920627 | 0.9621604 | 0.69206 | NA | NA |
| BCOR | cabozantinib | 0.6921730 | 0.9621604 | 0.69217 | NA | NA |
| ASXL1 | erlotinib | 0.6922632 | 0.9621604 | 0.69226 | NA | NA |
| JAK2 | olaparib | 0.6925765 | 0.9621604 | 0.69258 | NA | NA |
| SSX1 | fulvestrant | 0.6927026 | 0.9621604 | 0.69270 | NA | NA |
| TP53 | trametinib | 0.6932167 | 0.9621604 | 0.69322 | NA | NA |
| PIK3CA | cyclophosphamide | 0.6933966 | 0.9621604 | 0.69340 | NA | NA |
| ERBB4 | nilotinib | 0.6934143 | 0.9621604 | 0.69341 | NA | NA |
| NT5C2 | temozolomide | 0.6942653 | 0.9627493 | 0.69427 | NA | NA |
| PML | regorafenib | 0.6943881 | 0.9627493 | 0.69439 | NA | NA |
| EML4 | cyclophosphamide | 0.6949692 | 0.9630342 | 0.69497 | NA | NA |
| WT1 | temozolomide | 0.6954830 | 0.9630342 | 0.69548 | NA | NA |
| MYCN | vandetanib | 0.6957178 | 0.9630342 | 0.69572 | NA | NA |
| ERBB3 | afatinib | 0.6959010 | 0.9630342 | 0.69590 | NA | NA |
| EGFR | fulvestrant | 0.6967086 | 0.9630342 | 0.69671 | NA | NA |
| EML4 | sunitinib | 0.6967922 | 0.9630342 | 0.69679 | NA | NA |
| WHSC1 | cyclophosphamide | 0.6970829 | 0.9630342 | 0.69708 | NA | NA |
| PTEN | dasatinib | 0.6975741 | 0.9630342 | 0.69757 | NA | NA |
| RPL10 | olaparib | 0.6980888 | 0.9630342 | 0.69809 | NA | NA |
| PDCD1 | fluorouracil | 0.6985276 | 0.9630342 | 0.69853 | NA | NA |
| IDH1 | pazopanib | 0.6985333 | 0.9630342 | 0.69853 | NA | NA |
| SSX1 | olaparib | 0.6986268 | 0.9630342 | 0.69863 | NA | NA |
| KMT2A | pazopanib | 0.6990148 | 0.9630342 | 0.69901 | NA | NA |
| BRCA2 | dasatinib | 0.6990595 | 0.9630342 | 0.69906 | NA | NA |
| FGFR1 | olaparib | 0.6991197 | 0.9630342 | 0.69912 | NA | NA |
| MDM2 | ibrutinib | 0.6995678 | 0.9630342 | 0.69957 | NA | NA |
| AR | dabrafenib | 0.7000957 | 0.9630342 | 0.70010 | NA | NA |
| TSC2 | fluorouracil | 0.7001121 | 0.9630342 | 0.70011 | NA | NA |
| RPL10 | neratinib | 0.7004545 | 0.9630342 | 0.70045 | NA | NA |
| FGFR2 | gefitinib | 0.7006937 | 0.9630342 | 0.70069 | NA | NA |
| GNAQ | temozolomide | 0.7011843 | 0.9630342 | 0.70118 | NA | NA |
| ZRSR2 | imatinib | 0.7013451 | 0.9630342 | 0.70135 | NA | NA |
| NOTCH2 | selumetinib | 0.7015095 | 0.9630342 | 0.70151 | NA | NA |
| ZRSR2 | pazopanib | 0.7015106 | 0.9630342 | 0.70151 | NA | NA |
| TP53 | afatinib | 0.7019233 | 0.9630342 | 0.70192 | NA | NA |
| GATA1 | olaparib | 0.7020064 | 0.9630342 | 0.70201 | NA | NA |
| PHF6 | olaparib | 0.7021468 | 0.9630342 | 0.70215 | NA | NA |
| IDH1 | olaparib | 0.7022868 | 0.9630342 | 0.70229 | NA | NA |
| U2AF1 | ruxolitinib | 0.7030466 | 0.9634116 | 0.70305 | NA | NA |
| RPL10 | dasatinib | 0.7040324 | 0.9634116 | 0.70403 | NA | NA |
| RUNX1 | cyclophosphamide | 0.7043026 | 0.9634116 | 0.70430 | NA | NA |
| U2AF1 | dasatinib | 0.7043846 | 0.9634116 | 0.70438 | NA | NA |
| SF1 | fulvestrant | 0.7044519 | 0.9634116 | 0.70445 | NA | NA |
| G6PD | pazopanib | 0.7046983 | 0.9634116 | 0.70470 | NA | NA |
| GATA1 | cyclophosphamide | 0.7049215 | 0.9634116 | 0.70492 | NA | NA |
| IDH1 | vemurafenib | 0.7055156 | 0.9634116 | 0.70552 | NA | NA |
| KRAS | belinostat | 0.7060390 | 0.9634116 | 0.70604 | NA | NA |
| PAX8 | fluorouracil | 0.7064565 | 0.9634116 | 0.70646 | NA | NA |
| EED | ruxolitinib | 0.7067811 | 0.9634116 | 0.70678 | NA | NA |
| GATA2 | belinostat | 0.7068202 | 0.9634116 | 0.70682 | NA | NA |
| MAP2K1 | sunitinib | 0.7069036 | 0.9634116 | 0.70690 | NA | NA |
| PDGFRB | azd | 0.7069233 | 0.9634116 | 0.70692 | NA | NA |
| SETD2 | olaparib | 0.7069566 | 0.9634116 | 0.70696 | NA | NA |
| BRCA2 | imatinib | 0.7069599 | 0.9634116 | 0.70696 | NA | NA |
| BRCA1 | vandetanib | 0.7073522 | 0.9635716 | 0.70735 | NA | NA |
| VHL | vandetanib | 0.7088639 | 0.9649548 | 0.70886 | NA | NA |
| CBLB | crizotinib | 0.7089581 | 0.9649548 | 0.70896 | NA | NA |
| AR | cyclophosphamide | 0.7092023 | 0.9649548 | 0.70920 | NA | NA |
| MAP2K2 | olaparib | 0.7095442 | 0.9649548 | 0.70954 | NA | NA |
| CDKN2A | afatinib | 0.7097442 | 0.9649548 | 0.70974 | NA | NA |
| CRLF2 | olaparib | 0.7101393 | 0.9649794 | 0.71014 | NA | NA |
| PTPN11 | sunitinib | 0.7106955 | 0.9649794 | 0.71070 | NA | NA |
| NCOA2 | olaparib | 0.7107660 | 0.9649794 | 0.71077 | NA | NA |
| UGT1A1 | erlotinib | 0.7111266 | 0.9649794 | 0.71113 | NA | NA |
| SRSF2 | sunitinib | 0.7111389 | 0.9649794 | 0.71114 | NA | NA |
| MYCN | belinostat | 0.7115578 | 0.9650508 | 0.71156 | NA | NA |
| CTNNB1 | belinostat | 0.7117860 | 0.9650508 | 0.71179 | NA | NA |
| MAP2K2 | crizotinib | 0.7120175 | 0.9650508 | 0.71202 | NA | NA |
| FGFR2 | pazopanib | 0.7124035 | 0.9652007 | 0.71240 | NA | NA |
| CEBPA | nilotinib | 0.7130434 | 0.9656943 | 0.71304 | NA | NA |
| HRAS | fluorouracil | 0.7142040 | 0.9663251 | 0.71420 | NA | NA |
| AR | regorafenib | 0.7142612 | 0.9663251 | 0.71426 | NA | NA |
| FGFR3 | belinostat | 0.7144763 | 0.9663251 | 0.71448 | NA | NA |
| MDM2 | lapatinib | 0.7148489 | 0.9663251 | 0.71485 | NA | NA |
| CEBPA | ruxolitinib | 0.7148876 | 0.9663251 | 0.71489 | NA | NA |
| CREBBP | pazopanib | 0.7158874 | 0.9667582 | 0.71589 | NA | NA |
| SMC3 | ibrutinib | 0.7161679 | 0.9667582 | 0.71617 | NA | NA |
| CBLB | imatinib | 0.7163256 | 0.9667582 | 0.71633 | NA | NA |
| NT5C2 | ruxolitinib | 0.7164474 | 0.9667582 | 0.71645 | NA | NA |
| FGFR1 | azd | 0.7172445 | 0.9667582 | 0.71724 | NA | NA |
| FGFR2 | dasatinib | 0.7174691 | 0.9667582 | 0.71747 | NA | NA |
| WHSC1 | gefitinib | 0.7175619 | 0.9667582 | 0.71756 | NA | NA |
| NRAS | crizotinib | 0.7175748 | 0.9667582 | 0.71757 | NA | NA |
| ASXL1 | cyclophosphamide | 0.7179652 | 0.9667582 | 0.71797 | NA | NA |
| GATA2 | fulvestrant | 0.7180988 | 0.9667582 | 0.71810 | NA | NA |
| FLT3 | gefitinib | 0.7182420 | 0.9667582 | 0.71824 | NA | NA |
| SETBP1 | neratinib | 0.7187432 | 0.9670614 | 0.71874 | NA | NA |
| GNAS | dasatinib | 0.7192252 | 0.9673385 | 0.71923 | NA | NA |
| EML4 | cabozantinib | 0.7198333 | 0.9677003 | 0.71983 | NA | NA |
| PIK3CA | belinostat | 0.7210139 | 0.9677003 | 0.72101 | NA | NA |
| CBL | ibrutinib | 0.7210228 | 0.9677003 | 0.72102 | NA | NA |
| EGF | sunitinib | 0.7212933 | 0.9677003 | 0.72129 | NA | NA |
| BCORL1 | pazopanib | 0.7216830 | 0.9677003 | 0.72168 | NA | NA |
| TSC1 | belinostat | 0.7219457 | 0.9677003 | 0.72195 | NA | NA |
| BCOR | selumetinib | 0.7222666 | 0.9677003 | 0.72227 | NA | NA |
| SETD2 | selumetinib | 0.7229335 | 0.9677003 | 0.72293 | NA | NA |
| ETV6 | vandetanib | 0.7232830 | 0.9677003 | 0.72328 | NA | NA |
| CSF3R | trametinib | 0.7240083 | 0.9677003 | 0.72401 | NA | NA |
| RAD21 | trametinib | 0.7246309 | 0.9677003 | 0.72463 | NA | NA |
| STAG2 | fluorouracil | 0.7248455 | 0.9677003 | 0.72485 | NA | NA |
| CDK6 | fulvestrant | 0.7251029 | 0.9677003 | 0.72510 | NA | NA |
| CD274 | selumetinib | 0.7251513 | 0.9677003 | 0.72515 | NA | NA |
| ROS1 | vandetanib | 0.7251785 | 0.9677003 | 0.72518 | NA | NA |
| WHSC1 | vandetanib | 0.7255347 | 0.9677003 | 0.72553 | NA | NA |
| CD79B | olaparib | 0.7257215 | 0.9677003 | 0.72572 | NA | NA |
| FLT3 | erlotinib | 0.7258031 | 0.9677003 | 0.72580 | NA | NA |
| GNAS | vemurafenib | 0.7258712 | 0.9677003 | 0.72587 | NA | NA |
| PDGFB | vandetanib | 0.7261157 | 0.9677003 | 0.72612 | NA | NA |
| PDCD1 | selumetinib | 0.7265750 | 0.9677003 | 0.72658 | NA | NA |
| EZH2 | erlotinib | 0.7269678 | 0.9677003 | 0.72697 | NA | NA |
| RUNX1 | sunitinib | 0.7270184 | 0.9677003 | 0.72702 | NA | NA |
| EZH2 | ruxolitinib | 0.7272835 | 0.9677003 | 0.72728 | NA | NA |
| PDCD1 | crizotinib | 0.7274933 | 0.9677003 | 0.72749 | NA | NA |
| PRPF8 | lapatinib | 0.7276562 | 0.9677003 | 0.72766 | NA | NA |
| MET | fluorouracil | 0.7280738 | 0.9677003 | 0.72807 | NA | NA |
| FLT3 | trametinib | 0.7282232 | 0.9677003 | 0.72822 | NA | NA |
| CTNNB1 | crizotinib | 0.7283600 | 0.9677003 | 0.72836 | NA | NA |
| ROS1 | ibrutinib | 0.7285250 | 0.9677003 | 0.72853 | NA | NA |
| FGFR2 | azd | 0.7287078 | 0.9677003 | 0.72871 | NA | NA |
| GNAS | gefitinib | 0.7294199 | 0.9677003 | 0.72942 | NA | NA |
| SETD2 | belinostat | 0.7294787 | 0.9677003 | 0.72948 | NA | NA |
| SH2B3 | nilotinib | 0.7297621 | 0.9677003 | 0.72976 | NA | NA |
| PML | cyclophosphamide | 0.7303617 | 0.9677003 | 0.73036 | NA | NA |
| SETBP1 | crizotinib | 0.7305633 | 0.9677003 | 0.73056 | NA | NA |
| GNB1 | vandetanib | 0.7307398 | 0.9677003 | 0.73074 | NA | NA |
| MPL | olaparib | 0.7309281 | 0.9677003 | 0.73093 | NA | NA |
| AR | fluorouracil | 0.7309593 | 0.9677003 | 0.73096 | NA | NA |
| CRLF2 | regorafenib | 0.7312969 | 0.9677003 | 0.73130 | NA | NA |
| TSC1 | ruxolitinib | 0.7316331 | 0.9677003 | 0.73163 | NA | NA |
| KMT2A | regorafenib | 0.7316728 | 0.9677003 | 0.73167 | NA | NA |
| VHL | imatinib | 0.7319309 | 0.9677003 | 0.73193 | NA | NA |
| AKT1 | imatinib | 0.7320299 | 0.9677003 | 0.73203 | NA | NA |
| TSC2 | gefitinib | 0.7322403 | 0.9677003 | 0.73224 | NA | NA |
| PTCH1 | afatinib | 0.7324281 | 0.9677003 | 0.73243 | NA | NA |
| GNAS | fulvestrant | 0.7326959 | 0.9677003 | 0.73270 | NA | NA |
| CDK6 | vemurafenib | 0.7331417 | 0.9677003 | 0.73314 | NA | NA |
| ERBB3 | neratinib | 0.7332982 | 0.9677003 | 0.73330 | NA | NA |
| PDCD1 | cabozantinib | 0.7339747 | 0.9677003 | 0.73397 | NA | NA |
| AKT3 | dabrafenib | 0.7342271 | 0.9677003 | 0.73423 | NA | NA |
| FLT3 | selumetinib | 0.7342484 | 0.9677003 | 0.73425 | NA | NA |
| ERBB3 | fluorouracil | 0.7345804 | 0.9677003 | 0.73458 | NA | NA |
| ERBB2 | nilotinib | 0.7346282 | 0.9677003 | 0.73463 | NA | NA |
| IDH1 | belinostat | 0.7346792 | 0.9677003 | 0.73468 | NA | NA |
| FBXW7 | cyclophosphamide | 0.7350706 | 0.9678522 | 0.73507 | NA | NA |
| EGF | trametinib | 0.7355094 | 0.9680662 | 0.73551 | NA | NA |
| TSC1 | afatinib | 0.7361919 | 0.9681514 | 0.73619 | NA | NA |
| EML4 | imatinib | 0.7363143 | 0.9681514 | 0.73631 | NA | NA |
| RAD21 | regorafenib | 0.7364027 | 0.9681514 | 0.73640 | NA | NA |
| ASXL1 | ruxolitinib | 0.7368952 | 0.9684146 | 0.73690 | NA | NA |
| BTK | dabrafenib | 0.7372117 | 0.9684146 | 0.73721 | NA | NA |
| MDM2 | neratinib | 0.7374318 | 0.9684146 | 0.73743 | NA | NA |
| STAT3 | azd | 0.7382568 | 0.9691349 | 0.73826 | NA | NA |
| ZRSR2 | gefitinib | 0.7386653 | 0.9693081 | 0.73867 | NA | NA |
| PDGFB | sunitinib | 0.7395816 | 0.9700226 | 0.73958 | NA | NA |
| WT1 | pazopanib | 0.7397633 | 0.9700226 | 0.73976 | NA | NA |
| STAT3 | lapatinib | 0.7404090 | 0.9700268 | 0.74041 | NA | NA |
| SSX1 | vandetanib | 0.7404258 | 0.9700268 | 0.74043 | NA | NA |
| TP53 | gefitinib | 0.7405968 | 0.9700268 | 0.74060 | NA | NA |
| GNB1 | regorafenib | 0.7416132 | 0.9705976 | 0.74161 | NA | NA |
| CALR | sunitinib | 0.7418629 | 0.9705976 | 0.74186 | NA | NA |
| PDGFRA | crizotinib | 0.7420103 | 0.9705976 | 0.74201 | NA | NA |
| SRSF2 | cyclophosphamide | 0.7424401 | 0.9705976 | 0.74244 | NA | NA |
| UGT1A1 | nilotinib | 0.7429748 | 0.9705976 | 0.74297 | NA | NA |
| SETD2 | temozolomide | 0.7430517 | 0.9705976 | 0.74305 | NA | NA |
| CDK6 | vandetanib | 0.7434029 | 0.9705976 | 0.74340 | NA | NA |
| MGMT | selumetinib | 0.7434177 | 0.9705976 | 0.74342 | NA | NA |
| EZH2 | afatinib | 0.7435342 | 0.9705976 | 0.74353 | NA | NA |
| PML | vandetanib | 0.7438018 | 0.9705976 | 0.74380 | NA | NA |
| RUNX1 | neratinib | 0.7448410 | 0.9709248 | 0.74484 | NA | NA |
| EGF | fluorouracil | 0.7452435 | 0.9709248 | 0.74524 | NA | NA |
| G6PD | olaparib | 0.7455081 | 0.9709248 | 0.74551 | NA | NA |
| IL7R | pazopanib | 0.7460534 | 0.9709248 | 0.74605 | NA | NA |
| RAD21 | azd | 0.7464338 | 0.9709248 | 0.74643 | NA | NA |
| CD274 | ibrutinib | 0.7471826 | 0.9709248 | 0.74718 | NA | NA |
| FANCL | erlotinib | 0.7475280 | 0.9709248 | 0.74753 | NA | NA |
| MYCN | sunitinib | 0.7475925 | 0.9709248 | 0.74759 | NA | NA |
| IKZF1 | afatinib | 0.7476410 | 0.9709248 | 0.74764 | NA | NA |
| BRCA2 | gefitinib | 0.7477970 | 0.9709248 | 0.74780 | NA | NA |
| CTLA4 | olaparib | 0.7480065 | 0.9709248 | 0.74801 | NA | NA |
| TSC2 | imatinib | 0.7480994 | 0.9709248 | 0.74810 | NA | NA |
| JAK2 | selumetinib | 0.7485902 | 0.9709248 | 0.74859 | NA | NA |
| EML4 | neratinib | 0.7486205 | 0.9709248 | 0.74862 | NA | NA |
| GNAS | dabrafenib | 0.7487418 | 0.9709248 | 0.74874 | NA | NA |
| CTNNB1 | vandetanib | 0.7488945 | 0.9709248 | 0.74889 | NA | NA |
| KMT2A | dabrafenib | 0.7496294 | 0.9709248 | 0.74963 | NA | NA |
| DPYD | crizotinib | 0.7496551 | 0.9709248 | 0.74966 | NA | NA |
| PIK3CA | vandetanib | 0.7497566 | 0.9709248 | 0.74976 | NA | NA |
| PDCD1 | olaparib | 0.7498380 | 0.9709248 | 0.74984 | NA | NA |
| MPL | dabrafenib | 0.7498697 | 0.9709248 | 0.74987 | NA | NA |
| GATA1 | temozolomide | 0.7505399 | 0.9714337 | 0.75054 | NA | NA |
| MYD88 | crizotinib | 0.7508273 | 0.9714469 | 0.75083 | NA | NA |
| RAD21 | ibrutinib | 0.7522001 | 0.9726449 | 0.75220 | NA | NA |
| U2AF1 | gefitinib | 0.7523082 | 0.9726449 | 0.75231 | NA | NA |
| FGFR3 | gefitinib | 0.7528586 | 0.9729975 | 0.75286 | NA | NA |
| PDGFRB | dasatinib | 0.7535038 | 0.9734724 | 0.75350 | NA | NA |
| BTK | vemurafenib | 0.7544061 | 0.9738676 | 0.75441 | NA | NA |
| PTCH1 | gefitinib | 0.7546944 | 0.9738676 | 0.75469 | NA | NA |
| PDGFRB | dabrafenib | 0.7547325 | 0.9738676 | 0.75473 | NA | NA |
| IL7R | belinostat | 0.7551750 | 0.9738676 | 0.75518 | NA | NA |
| GNA11 | pazopanib | 0.7551989 | 0.9738676 | 0.75520 | NA | NA |
| DDIT3 | gefitinib | 0.7557663 | 0.9742408 | 0.75577 | NA | NA |
| FGFR3 | fluorouracil | 0.7561675 | 0.9743997 | 0.75617 | NA | NA |
| DNAJB1 | vandetanib | 0.7567350 | 0.9747726 | 0.75674 | NA | NA |
| XPO1 | erlotinib | 0.7573883 | 0.9749020 | 0.75739 | NA | NA |
| CDK6 | pazopanib | 0.7573918 | 0.9749020 | 0.75739 | NA | NA |
| CBL | imatinib | 0.7585602 | 0.9759807 | 0.75856 | NA | NA |
| NPM1 | olaparib | 0.7587867 | 0.9759807 | 0.75879 | NA | NA |
| NOTCH1 | erlotinib | 0.7601599 | 0.9769158 | 0.76016 | NA | NA |
| MAP2K1 | ruxolitinib | 0.7605973 | 0.9769158 | 0.76060 | NA | NA |
| SMC1A | lapatinib | 0.7611075 | 0.9769158 | 0.76111 | NA | NA |
| G6PD | temozolomide | 0.7612249 | 0.9769158 | 0.76122 | NA | NA |
| SSX1 | fluorouracil | 0.7615349 | 0.9769158 | 0.76153 | NA | NA |
| SETD2 | erlotinib | 0.7615497 | 0.9769158 | 0.76155 | NA | NA |
| PDGFRB | lapatinib | 0.7618885 | 0.9769158 | 0.76189 | NA | NA |
| FGFR2 | erlotinib | 0.7624511 | 0.9769158 | 0.76245 | NA | NA |
| NCOA2 | dabrafenib | 0.7624986 | 0.9769158 | 0.76250 | NA | NA |
| PAX5 | imatinib | 0.7627272 | 0.9769158 | 0.76273 | NA | NA |
| SETBP1 | pazopanib | 0.7627633 | 0.9769158 | 0.76276 | NA | NA |
| ETV6 | trametinib | 0.7628584 | 0.9769158 | 0.76286 | NA | NA |
| BTK | crizotinib | 0.7632016 | 0.9769984 | 0.76320 | NA | NA |
| BRCA2 | regorafenib | 0.7635037 | 0.9770283 | 0.76350 | NA | NA |
| CD79B | dasatinib | 0.7638200 | 0.9770763 | 0.76382 | NA | NA |
| SF3B1 | dabrafenib | 0.7642395 | 0.9772563 | 0.76424 | NA | NA |
| PAX5 | pazopanib | 0.7646165 | 0.9773818 | 0.76462 | NA | NA |
| BCOR | dasatinib | 0.7654574 | 0.9781000 | 0.76546 | NA | NA |
| SRSF2 | dabrafenib | 0.7662650 | 0.9784357 | 0.76627 | NA | NA |
| DPYD | imatinib | 0.7666734 | 0.9784357 | 0.76667 | NA | NA |
| JAK1 | fulvestrant | 0.7668957 | 0.9784357 | 0.76690 | NA | NA |
| GATA2 | crizotinib | 0.7673245 | 0.9784357 | 0.76732 | NA | NA |
| RAD21 | erlotinib | 0.7673369 | 0.9784357 | 0.76734 | NA | NA |
| WT1 | olaparib | 0.7676886 | 0.9784357 | 0.76769 | NA | NA |
| TSC2 | olaparib | 0.7680842 | 0.9784357 | 0.76808 | NA | NA |
| EGFR | sunitinib | 0.7681397 | 0.9784357 | 0.76814 | NA | NA |
| BCOR | neratinib | 0.7684625 | 0.9784357 | 0.76846 | NA | NA |
| SH2B3 | fluorouracil | 0.7685908 | 0.9784357 | 0.76859 | NA | NA |
| MAP2K1 | trametinib | 0.7690588 | 0.9784357 | 0.76906 | NA | NA |
| EZH2 | fluorouracil | 0.7690864 | 0.9784357 | 0.76909 | NA | NA |
| DPYD | fluorouracil | 0.7693491 | 0.9784357 | 0.76935 | NA | NA |
| RPL10 | cyclophosphamide | 0.7703411 | 0.9786997 | 0.77034 | NA | NA |
| IKZF1 | fluorouracil | 0.7704918 | 0.9786997 | 0.77049 | NA | NA |
| RPL10 | fulvestrant | 0.7708354 | 0.9786997 | 0.77084 | NA | NA |
| IKZF1 | pazopanib | 0.7712041 | 0.9786997 | 0.77120 | NA | NA |
| CD79B | imatinib | 0.7712534 | 0.9786997 | 0.77125 | NA | NA |
| FLT3 | sunitinib | 0.7714998 | 0.9786997 | 0.77150 | NA | NA |
| MYD88 | dasatinib | 0.7715129 | 0.9786997 | 0.77151 | NA | NA |
| EGFR | fluorouracil | 0.7720863 | 0.9786997 | 0.77209 | NA | NA |
| U2AF1 | fulvestrant | 0.7724007 | 0.9786997 | 0.77240 | NA | NA |
| ERBB2 | ibrutinib | 0.7726805 | 0.9786997 | 0.77268 | NA | NA |
| PDGFRB | vandetanib | 0.7728525 | 0.9786997 | 0.77285 | NA | NA |
| SETBP1 | fulvestrant | 0.7730012 | 0.9786997 | 0.77300 | NA | NA |
| SSX1 | sunitinib | 0.7734115 | 0.9786997 | 0.77341 | NA | NA |
| TSC2 | belinostat | 0.7739206 | 0.9786997 | 0.77392 | NA | NA |
| NOTCH2 | pazopanib | 0.7741025 | 0.9786997 | 0.77410 | NA | NA |
| ERBB4 | vandetanib | 0.7741921 | 0.9786997 | 0.77419 | NA | NA |
| CDKN2A | lapatinib | 0.7743037 | 0.9786997 | 0.77430 | NA | NA |
| AR | imatinib | 0.7746762 | 0.9788177 | 0.77468 | NA | NA |
| NOTCH1 | dabrafenib | 0.7752521 | 0.9790528 | 0.77525 | NA | NA |
| MDM2 | nilotinib | 0.7754957 | 0.9790528 | 0.77550 | NA | NA |
| PDCD1 | cyclophosphamide | 0.7757004 | 0.9790528 | 0.77570 | NA | NA |
| SF3B1 | dasatinib | 0.7765427 | 0.9790766 | 0.77654 | NA | NA |
| GATA2 | gefitinib | 0.7766051 | 0.9790766 | 0.77661 | NA | NA |
| PTPN11 | belinostat | 0.7770641 | 0.9790766 | 0.77706 | NA | NA |
| UGT1A1 | vemurafenib | 0.7774617 | 0.9790766 | 0.77746 | NA | NA |
| CDK4 | neratinib | 0.7775511 | 0.9790766 | 0.77755 | NA | NA |
| MYCN | cabozantinib | 0.7776618 | 0.9790766 | 0.77766 | NA | NA |
| ESR1 | dasatinib | 0.7776986 | 0.9790766 | 0.77770 | NA | NA |
| PHF6 | cyclophosphamide | 0.7780757 | 0.9790766 | 0.77808 | NA | NA |
| CBLB | dasatinib | 0.7786025 | 0.9790766 | 0.77860 | NA | NA |
| SMC3 | belinostat | 0.7787676 | 0.9790766 | 0.77877 | NA | NA |
| KIT | dasatinib | 0.7790279 | 0.9790766 | 0.77903 | NA | NA |
| MYD88 | regorafenib | 0.7798439 | 0.9790766 | 0.77984 | NA | NA |
| KMT2A | afatinib | 0.7799359 | 0.9790766 | 0.77994 | NA | NA |
| MPL | belinostat | 0.7800283 | 0.9790766 | 0.78003 | NA | NA |
| ABL1 | dasatinib | 0.7801253 | 0.9790766 | 0.78013 | NA | NA |
| ERBB4 | trametinib | 0.7804050 | 0.9790766 | 0.78040 | NA | NA |
| ROS1 | dasatinib | 0.7804679 | 0.9790766 | 0.78047 | NA | NA |
| BRCA1 | erlotinib | 0.7809136 | 0.9792853 | 0.78091 | NA | NA |
| MYD88 | selumetinib | 0.7817427 | 0.9798641 | 0.78174 | NA | NA |
| SETBP1 | regorafenib | 0.7820389 | 0.9798641 | 0.78204 | NA | NA |
| RET | ibrutinib | 0.7824502 | 0.9798641 | 0.78245 | NA | NA |
| FGFR2 | nilotinib | 0.7828534 | 0.9798641 | 0.78285 | NA | NA |
| EGFR | belinostat | 0.7834615 | 0.9798641 | 0.78346 | NA | NA |
| ERBB4 | dabrafenib | 0.7835462 | 0.9798641 | 0.78355 | NA | NA |
| SMO | ibrutinib | 0.7840036 | 0.9798641 | 0.78400 | NA | NA |
| CRLF2 | temozolomide | 0.7841940 | 0.9798641 | 0.78419 | NA | NA |
| JAK3 | sunitinib | 0.7843429 | 0.9798641 | 0.78434 | NA | NA |
| CYP19A1 | neratinib | 0.7845031 | 0.9798641 | 0.78450 | NA | NA |
| SMC1A | ruxolitinib | 0.7848184 | 0.9798641 | 0.78482 | NA | NA |
| MET | belinostat | 0.7848683 | 0.9798641 | 0.78487 | NA | NA |
| PDGFRB | cyclophosphamide | 0.7850095 | 0.9798641 | 0.78501 | NA | NA |
| KMT2A | cyclophosphamide | 0.7858531 | 0.9799978 | 0.78585 | NA | NA |
| RPL10 | pazopanib | 0.7859022 | 0.9799978 | 0.78590 | NA | NA |
| ASXL1 | sunitinib | 0.7862155 | 0.9799978 | 0.78622 | NA | NA |
| PTPN11 | regorafenib | 0.7868640 | 0.9799978 | 0.78686 | NA | NA |
| GNB1 | crizotinib | 0.7868725 | 0.9799978 | 0.78687 | NA | NA |
| STAT3 | fluorouracil | 0.7872285 | 0.9799978 | 0.78723 | NA | NA |
| RAD21 | dasatinib | 0.7873052 | 0.9799978 | 0.78731 | NA | NA |
| XPO1 | fulvestrant | 0.7873535 | 0.9799978 | 0.78735 | NA | NA |
| MGMT | cabozantinib | 0.7880782 | 0.9805517 | 0.78808 | NA | NA |
| MAP2K1 | fulvestrant | 0.7890076 | 0.9813166 | 0.78901 | NA | NA |
| RPL10 | crizotinib | 0.7894759 | 0.9813166 | 0.78948 | NA | NA |
| PHF6 | dabrafenib | 0.7898112 | 0.9813166 | 0.78981 | NA | NA |
| JAK1 | crizotinib | 0.7899472 | 0.9813166 | 0.78995 | NA | NA |
| BRCA1 | trametinib | 0.7902084 | 0.9813166 | 0.79021 | NA | NA |
| ALK | pazopanib | 0.7907566 | 0.9813166 | 0.79076 | NA | NA |
| SMO | olaparib | 0.7908167 | 0.9813166 | 0.79082 | NA | NA |
| ERBB4 | dasatinib | 0.7911289 | 0.9813166 | 0.79113 | NA | NA |
| NPM1 | trametinib | 0.7912128 | 0.9813166 | 0.79121 | NA | NA |
| ETV6 | belinostat | 0.7917541 | 0.9813278 | 0.79175 | NA | NA |
| BCOR | fluorouracil | 0.7920251 | 0.9813278 | 0.79203 | NA | NA |
| MAP2K1 | erlotinib | 0.7920617 | 0.9813278 | 0.79206 | NA | NA |
| NT5C2 | olaparib | 0.7936469 | 0.9828251 | 0.79365 | NA | NA |
| WHSC1 | nilotinib | 0.7941482 | 0.9828251 | 0.79415 | NA | NA |
| CDKN2A | dasatinib | 0.7947465 | 0.9828251 | 0.79475 | NA | NA |
| MYD88 | sunitinib | 0.7948466 | 0.9828251 | 0.79485 | NA | NA |
| FLT3 | fluorouracil | 0.7949588 | 0.9828251 | 0.79496 | NA | NA |
| EML4 | vandetanib | 0.7950423 | 0.9828251 | 0.79504 | NA | NA |
| CTNNB1 | selumetinib | 0.7952331 | 0.9828251 | 0.79523 | NA | NA |
| RIT1 | azd | 0.7955380 | 0.9828553 | 0.79554 | NA | NA |
| EZH2 | fulvestrant | 0.7961364 | 0.9828994 | 0.79614 | NA | NA |
| BRCA2 | fulvestrant | 0.7961724 | 0.9828994 | 0.79617 | NA | NA |
| ESR1 | vandetanib | 0.7965042 | 0.9828994 | 0.79650 | NA | NA |
| CREBBP | vemurafenib | 0.7967408 | 0.9828994 | 0.79674 | NA | NA |
| IDH2 | belinostat | 0.7972643 | 0.9828994 | 0.79726 | NA | NA |
| RIT1 | belinostat | 0.7972643 | 0.9828994 | 0.79726 | NA | NA |
| ERBB4 | imatinib | 0.7978043 | 0.9828994 | 0.79780 | NA | NA |
| GATA1 | erlotinib | 0.7979982 | 0.9828994 | 0.79800 | NA | NA |
| CDK6 | cyclophosphamide | 0.7980975 | 0.9828994 | 0.79810 | NA | NA |
| CBLB | olaparib | 0.7988492 | 0.9834797 | 0.79885 | NA | NA |
| CEBPA | belinostat | 0.7998303 | 0.9836788 | 0.79983 | NA | NA |
| NPM1 | regorafenib | 0.8002281 | 0.9836788 | 0.80023 | NA | NA |
| GNAQ | belinostat | 0.8002706 | 0.9836788 | 0.80027 | NA | NA |
| ROS1 | dabrafenib | 0.8003190 | 0.9836788 | 0.80032 | NA | NA |
| NT5C2 | cyclophosphamide | 0.8013112 | 0.9836788 | 0.80131 | NA | NA |
| FGFR2 | crizotinib | 0.8015132 | 0.9836788 | 0.80151 | NA | NA |
| BCORL1 | ruxolitinib | 0.8017150 | 0.9836788 | 0.80171 | NA | NA |
| CDK4 | imatinib | 0.8018292 | 0.9836788 | 0.80183 | NA | NA |
| CYP19A1 | erlotinib | 0.8021724 | 0.9836788 | 0.80217 | NA | NA |
| EGF | lapatinib | 0.8021775 | 0.9836788 | 0.80218 | NA | NA |
| ETV6 | olaparib | 0.8024774 | 0.9836788 | 0.80248 | NA | NA |
| PIK3CA | ruxolitinib | 0.8031527 | 0.9836788 | 0.80315 | NA | NA |
| JAK3 | temozolomide | 0.8038280 | 0.9836788 | 0.80383 | NA | NA |
| TSC2 | dabrafenib | 0.8039511 | 0.9836788 | 0.80395 | NA | NA |
| ERBB2 | pazopanib | 0.8041509 | 0.9836788 | 0.80415 | NA | NA |
| PIGA | olaparib | 0.8041925 | 0.9836788 | 0.80419 | NA | NA |
| EGFR | imatinib | 0.8043300 | 0.9836788 | 0.80433 | NA | NA |
| CBLB | trametinib | 0.8043433 | 0.9836788 | 0.80434 | NA | NA |
| GATA2 | trametinib | 0.8043433 | 0.9836788 | 0.80434 | NA | NA |
| ERBB3 | vemurafenib | 0.8058873 | 0.9850988 | 0.80589 | NA | NA |
| GNB1 | gefitinib | 0.8060666 | 0.9850988 | 0.80607 | NA | NA |
| IDH2 | gefitinib | 0.8069304 | 0.9854890 | 0.80693 | NA | NA |
| AKT1 | fulvestrant | 0.8069482 | 0.9854890 | 0.80695 | NA | NA |
| SMC3 | fulvestrant | 0.8079031 | 0.9858125 | 0.80790 | NA | NA |
| PAX8 | lapatinib | 0.8079834 | 0.9858125 | 0.80798 | NA | NA |
| GATA1 | neratinib | 0.8080568 | 0.9858125 | 0.80806 | NA | NA |
| FGFR3 | neratinib | 0.8083390 | 0.9858135 | 0.80834 | NA | NA |
| PIGA | dabrafenib | 0.8089548 | 0.9858922 | 0.80895 | NA | NA |
| TPMT | temozolomide | 0.8089661 | 0.9858922 | 0.80897 | NA | NA |
| VHL | gefitinib | 0.8099428 | 0.9867395 | 0.80994 | NA | NA |
| NCOA2 | dasatinib | 0.8120663 | 0.9885620 | 0.81207 | NA | NA |
| NPM1 | dasatinib | 0.8123866 | 0.9885620 | 0.81239 | NA | NA |
| BRCA1 | olaparib | 0.8126710 | 0.9885620 | 0.81267 | NA | NA |
| EED | dabrafenib | 0.8127835 | 0.9885620 | 0.81278 | NA | NA |
| FLT3 | afatinib | 0.8136811 | 0.9885620 | 0.81368 | NA | NA |
| CTCF | cyclophosphamide | 0.8140252 | 0.9885620 | 0.81403 | NA | NA |
| ETV6 | afatinib | 0.8146140 | 0.9885620 | 0.81461 | NA | NA |
| MDM2 | selumetinib | 0.8147845 | 0.9885620 | 0.81478 | NA | NA |
| IL7R | temozolomide | 0.8147928 | 0.9885620 | 0.81479 | NA | NA |
| ETV6 | azd | 0.8153345 | 0.9885620 | 0.81533 | NA | NA |
| DDIT3 | vandetanib | 0.8153829 | 0.9885620 | 0.81538 | NA | NA |
| BCOR | ibrutinib | 0.8155517 | 0.9885620 | 0.81555 | NA | NA |
| MAP2K1 | dasatinib | 0.8156483 | 0.9885620 | 0.81565 | NA | NA |
| TSC2 | pazopanib | 0.8156658 | 0.9885620 | 0.81567 | NA | NA |
| SMC3 | neratinib | 0.8156695 | 0.9885620 | 0.81567 | NA | NA |
| CDC73 | lapatinib | 0.8163306 | 0.9887995 | 0.81633 | NA | NA |
| GNB1 | temozolomide | 0.8165080 | 0.9887995 | 0.81651 | NA | NA |
| CXCR4 | fluorouracil | 0.8170913 | 0.9887995 | 0.81709 | NA | NA |
| PIK3CA | afatinib | 0.8171902 | 0.9887995 | 0.81719 | NA | NA |
| EGFR | selumetinib | 0.8175946 | 0.9887995 | 0.81759 | NA | NA |
| KRAS | fluorouracil | 0.8178870 | 0.9887995 | 0.81789 | NA | NA |
| TET2 | dasatinib | 0.8180732 | 0.9887995 | 0.81807 | NA | NA |
| SMC1A | dabrafenib | 0.8181790 | 0.9887995 | 0.81818 | NA | NA |
| GNA11 | belinostat | 0.8191068 | 0.9887995 | 0.81911 | NA | NA |
| MYCN | temozolomide | 0.8196022 | 0.9887995 | 0.81960 | NA | NA |
| DNMT3A | dabrafenib | 0.8196290 | 0.9887995 | 0.81963 | NA | NA |
| RAD21 | fulvestrant | 0.8197611 | 0.9887995 | 0.81976 | NA | NA |
| KRAS | erlotinib | 0.8197849 | 0.9887995 | 0.81978 | NA | NA |
| STAG2 | dasatinib | 0.8200451 | 0.9887995 | 0.82005 | NA | NA |
| JAK2 | ruxolitinib | 0.8206972 | 0.9887995 | 0.82070 | NA | NA |
| ABL1 | neratinib | 0.8209775 | 0.9887995 | 0.82098 | NA | NA |
| CEBPA | fluorouracil | 0.8210173 | 0.9887995 | 0.82102 | NA | NA |
| TET2 | ibrutinib | 0.8210622 | 0.9887995 | 0.82106 | NA | NA |
| JAK2 | pazopanib | 0.8212255 | 0.9887995 | 0.82123 | NA | NA |
| GNAQ | azd | 0.8215610 | 0.9888638 | 0.82156 | NA | NA |
| ESR1 | afatinib | 0.8221452 | 0.9892272 | 0.82215 | NA | NA |
| WT1 | regorafenib | 0.8227347 | 0.9895969 | 0.82273 | NA | NA |
| AKT2 | cabozantinib | 0.8236951 | 0.9900197 | 0.82370 | NA | NA |
| AKT2 | ruxolitinib | 0.8237974 | 0.9900197 | 0.82380 | NA | NA |
| SH2B3 | erlotinib | 0.8239336 | 0.9900197 | 0.82393 | NA | NA |
| AKT1 | selumetinib | 0.8255265 | 0.9901690 | 0.82553 | NA | NA |
| ERBB3 | dasatinib | 0.8265066 | 0.9901690 | 0.82651 | NA | NA |
| ERBB3 | regorafenib | 0.8265906 | 0.9901690 | 0.82659 | NA | NA |
| SF3B1 | crizotinib | 0.8266905 | 0.9901690 | 0.82669 | NA | NA |
| G6PD | belinostat | 0.8270727 | 0.9901690 | 0.82707 | NA | NA |
| ASXL1 | azd | 0.8276807 | 0.9901690 | 0.82768 | NA | NA |
| WHSC1 | azd | 0.8277442 | 0.9901690 | 0.82774 | NA | NA |
| BCORL1 | fulvestrant | 0.8280004 | 0.9901690 | 0.82800 | NA | NA |
| BRCA2 | sunitinib | 0.8280670 | 0.9901690 | 0.82807 | NA | NA |
| WT1 | ruxolitinib | 0.8282677 | 0.9901690 | 0.82827 | NA | NA |
| CDC73 | pazopanib | 0.8285791 | 0.9901690 | 0.82858 | NA | NA |
| CDC73 | dabrafenib | 0.8289484 | 0.9901690 | 0.82895 | NA | NA |
| RUNX1 | fulvestrant | 0.8302092 | 0.9901690 | 0.83021 | NA | NA |
| CXCR4 | cyclophosphamide | 0.8303971 | 0.9901690 | 0.83040 | NA | NA |
| PDCD1 | temozolomide | 0.8304264 | 0.9901690 | 0.83043 | NA | NA |
| SSX1 | trametinib | 0.8304781 | 0.9901690 | 0.83048 | NA | NA |
| EML4 | ruxolitinib | 0.8305349 | 0.9901690 | 0.83053 | NA | NA |
| TSC2 | regorafenib | 0.8307456 | 0.9901690 | 0.83075 | NA | NA |
| TET2 | imatinib | 0.8307873 | 0.9901690 | 0.83079 | NA | NA |
| CXCR4 | olaparib | 0.8315103 | 0.9901690 | 0.83151 | NA | NA |
| XPO1 | imatinib | 0.8319911 | 0.9901690 | 0.83199 | NA | NA |
| STAG2 | fulvestrant | 0.8322921 | 0.9901690 | 0.83229 | NA | NA |
| AR | olaparib | 0.8323296 | 0.9901690 | 0.83233 | NA | NA |
| JAK3 | trametinib | 0.8326907 | 0.9901690 | 0.83269 | NA | NA |
| ABL1 | dabrafenib | 0.8331314 | 0.9901690 | 0.83313 | NA | NA |
| SRSF2 | selumetinib | 0.8333064 | 0.9901690 | 0.83331 | NA | NA |
| GNA11 | dabrafenib | 0.8333252 | 0.9901690 | 0.83333 | NA | NA |
| CD79B | azd | 0.8339485 | 0.9901690 | 0.83395 | NA | NA |
| CDKN2A | temozolomide | 0.8345836 | 0.9901690 | 0.83458 | NA | NA |
| WT1 | trametinib | 0.8346931 | 0.9901690 | 0.83469 | NA | NA |
| JAK2 | imatinib | 0.8347277 | 0.9901690 | 0.83473 | NA | NA |
| CDK6 | dasatinib | 0.8347746 | 0.9901690 | 0.83477 | NA | NA |
| GNAQ | trametinib | 0.8351033 | 0.9901690 | 0.83510 | NA | NA |
| RPL10 | afatinib | 0.8354031 | 0.9901690 | 0.83540 | NA | NA |
| GATA3 | nilotinib | 0.8356779 | 0.9901690 | 0.83568 | NA | NA |
| ABL1 | pazopanib | 0.8358559 | 0.9901690 | 0.83586 | NA | NA |
| FANCL | lapatinib | 0.8358929 | 0.9901690 | 0.83589 | NA | NA |
| CDKN2A | fulvestrant | 0.8364018 | 0.9901690 | 0.83640 | NA | NA |
| IL7R | sunitinib | 0.8364552 | 0.9901690 | 0.83646 | NA | NA |
| MPL | ibrutinib | 0.8367132 | 0.9901690 | 0.83671 | NA | NA |
| ERBB4 | ruxolitinib | 0.8371657 | 0.9901690 | 0.83717 | NA | NA |
| GATA2 | cyclophosphamide | 0.8372522 | 0.9901690 | 0.83725 | NA | NA |
| GATA2 | vandetanib | 0.8374238 | 0.9901690 | 0.83742 | NA | NA |
| SETD2 | gefitinib | 0.8377146 | 0.9901690 | 0.83771 | NA | NA |
| TPMT | nilotinib | 0.8378567 | 0.9901690 | 0.83786 | NA | NA |
| ATM | gefitinib | 0.8382793 | 0.9901690 | 0.83828 | NA | NA |
| JAK3 | fluorouracil | 0.8384838 | 0.9901690 | 0.83848 | NA | NA |
| BRCA2 | ruxolitinib | 0.8386749 | 0.9901690 | 0.83867 | NA | NA |
| CXCR4 | regorafenib | 0.8387356 | 0.9901690 | 0.83874 | NA | NA |
| CALR | fulvestrant | 0.8400737 | 0.9901690 | 0.84007 | NA | NA |
| MYCN | fulvestrant | 0.8400737 | 0.9901690 | 0.84007 | NA | NA |
| TPMT | fulvestrant | 0.8400737 | 0.9901690 | 0.84007 | NA | NA |
| CBLB | pazopanib | 0.8405158 | 0.9901690 | 0.84052 | NA | NA |
| WHSC1 | dasatinib | 0.8407025 | 0.9901690 | 0.84070 | NA | NA |
| FLCN | dabrafenib | 0.8408160 | 0.9901690 | 0.84082 | NA | NA |
| EML4 | regorafenib | 0.8409376 | 0.9901690 | 0.84094 | NA | NA |
| GNAQ | pazopanib | 0.8416682 | 0.9901690 | 0.84167 | NA | NA |
| FBXW7 | crizotinib | 0.8421141 | 0.9901690 | 0.84211 | NA | NA |
| MPL | neratinib | 0.8432221 | 0.9901690 | 0.84322 | NA | NA |
| KIT | belinostat | 0.8435673 | 0.9901690 | 0.84357 | NA | NA |
| ABL1 | sunitinib | 0.8440587 | 0.9901690 | 0.84406 | NA | NA |
| EGFR | cyclophosphamide | 0.8442118 | 0.9901690 | 0.84421 | NA | NA |
| TPMT | belinostat | 0.8445547 | 0.9901690 | 0.84455 | NA | NA |
| SSX1 | nilotinib | 0.8447109 | 0.9901690 | 0.84471 | NA | NA |
| PDGFRB | erlotinib | 0.8448409 | 0.9901690 | 0.84484 | NA | NA |
| PML | azd | 0.8448624 | 0.9901690 | 0.84486 | NA | NA |
| CSF3R | fulvestrant | 0.8452868 | 0.9901690 | 0.84529 | NA | NA |
| GNB1 | fulvestrant | 0.8452868 | 0.9901690 | 0.84529 | NA | NA |
| PDGFB | fulvestrant | 0.8455325 | 0.9901690 | 0.84553 | NA | NA |
| ATM | trametinib | 0.8460191 | 0.9901690 | 0.84602 | NA | NA |
| DNMT3A | belinostat | 0.8463546 | 0.9901690 | 0.84635 | NA | NA |
| SSX1 | dabrafenib | 0.8464862 | 0.9901690 | 0.84649 | NA | NA |
| NT5C2 | trametinib | 0.8473892 | 0.9901690 | 0.84739 | NA | NA |
| ALK | cabozantinib | 0.8474970 | 0.9901690 | 0.84750 | NA | NA |
| PIGA | afatinib | 0.8479000 | 0.9901690 | 0.84790 | NA | NA |
| SETBP1 | ruxolitinib | 0.8481381 | 0.9901690 | 0.84814 | NA | NA |
| JAK2 | belinostat | 0.8481782 | 0.9901690 | 0.84818 | NA | NA |
| AKT2 | cyclophosphamide | 0.8485860 | 0.9901690 | 0.84859 | NA | NA |
| ETV6 | pazopanib | 0.8487861 | 0.9901690 | 0.84879 | NA | NA |
| ESR1 | ruxolitinib | 0.8489985 | 0.9901690 | 0.84900 | NA | NA |
| MGMT | pazopanib | 0.8490601 | 0.9901690 | 0.84906 | NA | NA |
| BCORL1 | afatinib | 0.8491104 | 0.9901690 | 0.84911 | NA | NA |
| MDM2 | crizotinib | 0.8495487 | 0.9901690 | 0.84955 | NA | NA |
| WT1 | crizotinib | 0.8499747 | 0.9901690 | 0.84997 | NA | NA |
| PDGFB | afatinib | 0.8499921 | 0.9901690 | 0.84999 | NA | NA |
| AR | fulvestrant | 0.8505013 | 0.9901690 | 0.85050 | NA | NA |
| BRCA1 | ibrutinib | 0.8510774 | 0.9901690 | 0.85108 | NA | NA |
| SSX1 | pazopanib | 0.8510912 | 0.9901690 | 0.85109 | NA | NA |
| CDC73 | belinostat | 0.8513755 | 0.9901690 | 0.85138 | NA | NA |
| IDH2 | nilotinib | 0.8513822 | 0.9901690 | 0.85138 | NA | NA |
| FBXW7 | nilotinib | 0.8513899 | 0.9901690 | 0.85139 | NA | NA |
| ERBB4 | fulvestrant | 0.8515382 | 0.9901690 | 0.85154 | NA | NA |
| SH2B3 | olaparib | 0.8520608 | 0.9901690 | 0.85206 | NA | NA |
| VHL | erlotinib | 0.8523932 | 0.9901690 | 0.85239 | NA | NA |
| CYP19A1 | pazopanib | 0.8533966 | 0.9901690 | 0.85340 | NA | NA |
| NCOA2 | belinostat | 0.8534104 | 0.9901690 | 0.85341 | NA | NA |
| BTK | fluorouracil | 0.8538624 | 0.9901690 | 0.85386 | NA | NA |
| BCORL1 | regorafenib | 0.8541459 | 0.9901690 | 0.85415 | NA | NA |
| IKZF1 | ruxolitinib | 0.8543153 | 0.9901690 | 0.85432 | NA | NA |
| EZH2 | regorafenib | 0.8544445 | 0.9901690 | 0.85444 | NA | NA |
| EML4 | pazopanib | 0.8549461 | 0.9901690 | 0.85495 | NA | NA |
| PDGFRA | imatinib | 0.8550665 | 0.9901690 | 0.85507 | NA | NA |
| CDK4 | cyclophosphamide | 0.8551752 | 0.9901690 | 0.85518 | NA | NA |
| XPO1 | vandetanib | 0.8552812 | 0.9901690 | 0.85528 | NA | NA |
| BCORL1 | gefitinib | 0.8556379 | 0.9901690 | 0.85564 | NA | NA |
| PDGFB | crizotinib | 0.8558808 | 0.9901690 | 0.85588 | NA | NA |
| SF1 | trametinib | 0.8561422 | 0.9901690 | 0.85614 | NA | NA |
| PTCH1 | neratinib | 0.8565156 | 0.9901690 | 0.85652 | NA | NA |
| FLCN | azd | 0.8570215 | 0.9901690 | 0.85702 | NA | NA |
| CD79B | crizotinib | 0.8579080 | 0.9901690 | 0.85791 | NA | NA |
| CDK4 | olaparib | 0.8579502 | 0.9901690 | 0.85795 | NA | NA |
| G6PD | neratinib | 0.8580742 | 0.9901690 | 0.85807 | NA | NA |
| EED | cabozantinib | 0.8584187 | 0.9901690 | 0.85842 | NA | NA |
| GNA11 | regorafenib | 0.8586729 | 0.9901690 | 0.85867 | NA | NA |
| ATM | fluorouracil | 0.8591468 | 0.9901690 | 0.85915 | NA | NA |
| CDK6 | neratinib | 0.8593447 | 0.9901690 | 0.85934 | NA | NA |
| GNB1 | olaparib | 0.8596219 | 0.9901690 | 0.85962 | NA | NA |
| WT1 | dasatinib | 0.8598469 | 0.9901690 | 0.85985 | NA | NA |
| IL7R | cyclophosphamide | 0.8604368 | 0.9901690 | 0.86044 | NA | NA |
| CRLF2 | nilotinib | 0.8605840 | 0.9901690 | 0.86058 | NA | NA |
| GNA11 | vandetanib | 0.8607348 | 0.9901690 | 0.86073 | NA | NA |
| ERBB3 | temozolomide | 0.8609254 | 0.9901690 | 0.86093 | NA | NA |
| ASXL1 | dabrafenib | 0.8609421 | 0.9901690 | 0.86094 | NA | NA |
| ZRSR2 | afatinib | 0.8610270 | 0.9901690 | 0.86103 | NA | NA |
| PAX8 | selumetinib | 0.8611213 | 0.9901690 | 0.86112 | NA | NA |
| CDK4 | nilotinib | 0.8612838 | 0.9901690 | 0.86128 | NA | NA |
| FLT3 | neratinib | 0.8622113 | 0.9901690 | 0.86221 | NA | NA |
| ETV6 | neratinib | 0.8623161 | 0.9901690 | 0.86232 | NA | NA |
| ERBB3 | trametinib | 0.8637892 | 0.9901690 | 0.86379 | NA | NA |
| ROS1 | selumetinib | 0.8640047 | 0.9901690 | 0.86400 | NA | NA |
| PAX5 | crizotinib | 0.8641086 | 0.9901690 | 0.86411 | NA | NA |
| CDK4 | ibrutinib | 0.8648076 | 0.9901690 | 0.86481 | NA | NA |
| MET | ruxolitinib | 0.8650705 | 0.9901690 | 0.86507 | NA | NA |
| SETBP1 | ibrutinib | 0.8651240 | 0.9901690 | 0.86512 | NA | NA |
| MYCN | imatinib | 0.8657933 | 0.9901690 | 0.86579 | NA | NA |
| BTK | selumetinib | 0.8659890 | 0.9901690 | 0.86599 | NA | NA |
| CEBPA | olaparib | 0.8664644 | 0.9901690 | 0.86646 | NA | NA |
| TSC2 | selumetinib | 0.8665087 | 0.9901690 | 0.86651 | NA | NA |
| FGFR2 | olaparib | 0.8666403 | 0.9901690 | 0.86664 | NA | NA |
| PTPN11 | pazopanib | 0.8671743 | 0.9901690 | 0.86717 | NA | NA |
| AKT2 | sunitinib | 0.8673466 | 0.9901690 | 0.86735 | NA | NA |
| RAD21 | lapatinib | 0.8675443 | 0.9901690 | 0.86754 | NA | NA |
| PRPF40B | azd | 0.8675461 | 0.9901690 | 0.86755 | NA | NA |
| RIT1 | erlotinib | 0.8681157 | 0.9901690 | 0.86812 | NA | NA |
| CDC73 | azd | 0.8684061 | 0.9901690 | 0.86841 | NA | NA |
| DDIT3 | afatinib | 0.8686331 | 0.9901690 | 0.86863 | NA | NA |
| CEBPA | pazopanib | 0.8688202 | 0.9901690 | 0.86882 | NA | NA |
| RPL10 | sunitinib | 0.8688961 | 0.9901690 | 0.86890 | NA | NA |
| CDK6 | erlotinib | 0.8703063 | 0.9901690 | 0.87031 | NA | NA |
| ETV6 | imatinib | 0.8709192 | 0.9901690 | 0.87092 | NA | NA |
| GNAQ | vemurafenib | 0.8709776 | 0.9901690 | 0.87098 | NA | NA |
| EML4 | lapatinib | 0.8710187 | 0.9901690 | 0.87102 | NA | NA |
| BRCA1 | cyclophosphamide | 0.8713387 | 0.9901690 | 0.87134 | NA | NA |
| ALK | cyclophosphamide | 0.8716671 | 0.9901690 | 0.87167 | NA | NA |
| MAP2K2 | cabozantinib | 0.8719884 | 0.9901690 | 0.87199 | NA | NA |
| WT1 | cabozantinib | 0.8720627 | 0.9901690 | 0.87206 | NA | NA |
| CTNNB1 | dabrafenib | 0.8720644 | 0.9901690 | 0.87206 | NA | NA |
| PDCD1 | erlotinib | 0.8721579 | 0.9901690 | 0.87216 | NA | NA |
| ERBB2 | regorafenib | 0.8725903 | 0.9901690 | 0.87259 | NA | NA |
| CD79B | lapatinib | 0.8728609 | 0.9901690 | 0.87286 | NA | NA |
| CTCF | belinostat | 0.8730931 | 0.9901690 | 0.87309 | NA | NA |
| CALR | crizotinib | 0.8731382 | 0.9901690 | 0.87314 | NA | NA |
| IKZF1 | azd | 0.8732022 | 0.9901690 | 0.87320 | NA | NA |
| AR | ibrutinib | 0.8734298 | 0.9901690 | 0.87343 | NA | NA |
| EGFR | temozolomide | 0.8736252 | 0.9901690 | 0.87363 | NA | NA |
| ZRSR2 | neratinib | 0.8736410 | 0.9901690 | 0.87364 | NA | NA |
| ZRSR2 | sunitinib | 0.8739101 | 0.9901690 | 0.87391 | NA | NA |
| PML | ibrutinib | 0.8740839 | 0.9901690 | 0.87408 | NA | NA |
| STAG2 | erlotinib | 0.8742188 | 0.9901690 | 0.87422 | NA | NA |
| CBL | fluorouracil | 0.8743145 | 0.9901690 | 0.87431 | NA | NA |
| IKZF1 | belinostat | 0.8743214 | 0.9901690 | 0.87432 | NA | NA |
| RAD21 | neratinib | 0.8743887 | 0.9901690 | 0.87439 | NA | NA |
| KMT2A | ruxolitinib | 0.8745846 | 0.9901690 | 0.87458 | NA | NA |
| PAX5 | dasatinib | 0.8746189 | 0.9901690 | 0.87462 | NA | NA |
| NOTCH1 | ibrutinib | 0.8747156 | 0.9901690 | 0.87472 | NA | NA |
| DDIT3 | imatinib | 0.8751828 | 0.9901690 | 0.87518 | NA | NA |
| SF1 | pazopanib | 0.8761149 | 0.9901690 | 0.87611 | NA | NA |
| PHF6 | regorafenib | 0.8764457 | 0.9901690 | 0.87645 | NA | NA |
| IKZF1 | fulvestrant | 0.8765449 | 0.9901690 | 0.87654 | NA | NA |
| NRAS | azd | 0.8767650 | 0.9901690 | 0.87677 | NA | NA |
| IL7R | cabozantinib | 0.8768350 | 0.9901690 | 0.87683 | NA | NA |
| NOTCH1 | afatinib | 0.8771401 | 0.9901690 | 0.87714 | NA | NA |
| MET | ibrutinib | 0.8773082 | 0.9901690 | 0.87731 | NA | NA |
| EML4 | afatinib | 0.8779886 | 0.9901690 | 0.87799 | NA | NA |
| RAD21 | olaparib | 0.8780532 | 0.9901690 | 0.87805 | NA | NA |
| FGFR3 | dasatinib | 0.8781896 | 0.9901690 | 0.87819 | NA | NA |
| G6PD | erlotinib | 0.8787499 | 0.9901690 | 0.87875 | NA | NA |
| GNAS | fluorouracil | 0.8790478 | 0.9901690 | 0.87905 | NA | NA |
| EED | sunitinib | 0.8795398 | 0.9901690 | 0.87954 | NA | NA |
| CEBPA | erlotinib | 0.8795684 | 0.9901690 | 0.87957 | NA | NA |
| PDGFB | cabozantinib | 0.8796954 | 0.9901690 | 0.87970 | NA | NA |
| TET2 | ruxolitinib | 0.8800224 | 0.9901690 | 0.88002 | NA | NA |
| SETBP1 | fluorouracil | 0.8804096 | 0.9901690 | 0.88041 | NA | NA |
| WT1 | gefitinib | 0.8804501 | 0.9901690 | 0.88045 | NA | NA |
| CREBBP | azd | 0.8805935 | 0.9901690 | 0.88059 | NA | NA |
| SH2B3 | ruxolitinib | 0.8811335 | 0.9901690 | 0.88113 | NA | NA |
| BRCA1 | ruxolitinib | 0.8813093 | 0.9901690 | 0.88131 | NA | NA |
| GNAS | trametinib | 0.8817413 | 0.9901690 | 0.88174 | NA | NA |
| BTK | gefitinib | 0.8818601 | 0.9901690 | 0.88186 | NA | NA |
| ERBB3 | olaparib | 0.8819557 | 0.9901690 | 0.88196 | NA | NA |
| NPM1 | vemurafenib | 0.8824014 | 0.9901690 | 0.88240 | NA | NA |
| ESR1 | pazopanib | 0.8825243 | 0.9901690 | 0.88252 | NA | NA |
| ABL1 | vemurafenib | 0.8828642 | 0.9901690 | 0.88286 | NA | NA |
| JAK3 | afatinib | 0.8828760 | 0.9901690 | 0.88288 | NA | NA |
| BCORL1 | temozolomide | 0.8832119 | 0.9901690 | 0.88321 | NA | NA |
| NCOA2 | erlotinib | 0.8832155 | 0.9901690 | 0.88322 | NA | NA |
| PIK3CA | neratinib | 0.8835236 | 0.9901690 | 0.88352 | NA | NA |
| KIT | vemurafenib | 0.8838594 | 0.9901690 | 0.88386 | NA | NA |
| CXCR4 | gefitinib | 0.8843316 | 0.9901690 | 0.88433 | NA | NA |
| BRAF | crizotinib | 0.8847422 | 0.9901690 | 0.88474 | NA | NA |
| SRSF2 | nilotinib | 0.8848890 | 0.9901690 | 0.88489 | NA | NA |
| BCOR | belinostat | 0.8851071 | 0.9901690 | 0.88511 | NA | NA |
| MGMT | regorafenib | 0.8856536 | 0.9901690 | 0.88565 | NA | NA |
| CSF3R | ruxolitinib | 0.8856788 | 0.9901690 | 0.88568 | NA | NA |
| JAK1 | azd | 0.8862899 | 0.9901690 | 0.88629 | NA | NA |
| FLT3 | azd | 0.8863568 | 0.9901690 | 0.88636 | NA | NA |
| ZRSR2 | erlotinib | 0.8863915 | 0.9901690 | 0.88639 | NA | NA |
| DDIT3 | ruxolitinib | 0.8865939 | 0.9901690 | 0.88659 | NA | NA |
| TSC2 | fulvestrant | 0.8866945 | 0.9901690 | 0.88669 | NA | NA |
| MDM2 | vemurafenib | 0.8868806 | 0.9901690 | 0.88688 | NA | NA |
| RET | temozolomide | 0.8870447 | 0.9901690 | 0.88704 | NA | NA |
| CEBPA | dasatinib | 0.8870621 | 0.9901690 | 0.88706 | NA | NA |
| EGFR | gefitinib | 0.8875800 | 0.9901690 | 0.88758 | NA | NA |
| SSX1 | imatinib | 0.8883152 | 0.9901690 | 0.88832 | NA | NA |
| JAK1 | afatinib | 0.8886426 | 0.9901690 | 0.88864 | NA | NA |
| MYCN | ruxolitinib | 0.8887309 | 0.9901690 | 0.88873 | NA | NA |
| FANCL | fluorouracil | 0.8887309 | 0.9901690 | 0.88873 | NA | NA |
| MET | dasatinib | 0.8890135 | 0.9901690 | 0.88901 | NA | NA |
| AKT3 | pazopanib | 0.8894602 | 0.9901690 | 0.88946 | NA | NA |
| IKZF1 | gefitinib | 0.8895230 | 0.9901690 | 0.88952 | NA | NA |
| MAP2K1 | crizotinib | 0.8899455 | 0.9901690 | 0.88995 | NA | NA |
| BTK | ibrutinib | 0.8905387 | 0.9901690 | 0.89054 | NA | NA |
| FGFR3 | fulvestrant | 0.8912589 | 0.9901690 | 0.89126 | NA | NA |
| PML | neratinib | 0.8916365 | 0.9901690 | 0.89164 | NA | NA |
| SF3B1 | cabozantinib | 0.8924725 | 0.9901690 | 0.89247 | NA | NA |
| PDCD1 | fulvestrant | 0.8929813 | 0.9901690 | 0.89298 | NA | NA |
| ABL1 | erlotinib | 0.8935609 | 0.9901690 | 0.89356 | NA | NA |
| KMT2A | belinostat | 0.8939542 | 0.9901690 | 0.89395 | NA | NA |
| AKT3 | vandetanib | 0.8940163 | 0.9901690 | 0.89402 | NA | NA |
| KIT | nilotinib | 0.8943017 | 0.9901690 | 0.89430 | NA | NA |
| MGMT | ibrutinib | 0.8947146 | 0.9901690 | 0.89471 | NA | NA |
| JAK2 | lapatinib | 0.8953005 | 0.9901690 | 0.89530 | NA | NA |
| FANCL | dasatinib | 0.8954609 | 0.9901690 | 0.89546 | NA | NA |
| MET | imatinib | 0.8955374 | 0.9901690 | 0.89554 | NA | NA |
| PRPF40B | temozolomide | 0.8962251 | 0.9901690 | 0.89623 | NA | NA |
| PAX5 | temozolomide | 0.8962677 | 0.9901690 | 0.89627 | NA | NA |
| ERBB2 | lapatinib | 0.8966122 | 0.9901690 | 0.89661 | NA | NA |
| BRCA2 | fluorouracil | 0.8966696 | 0.9901690 | 0.89667 | NA | NA |
| CD274 | trametinib | 0.8969249 | 0.9901690 | 0.89692 | NA | NA |
| CALR | fluorouracil | 0.8969467 | 0.9901690 | 0.89695 | NA | NA |
| MYD88 | belinostat | 0.8969609 | 0.9901690 | 0.89696 | NA | NA |
| VHL | afatinib | 0.8971402 | 0.9901690 | 0.89714 | NA | NA |
| CTNNB1 | ruxolitinib | 0.8971632 | 0.9901690 | 0.89716 | NA | NA |
| CDK4 | gefitinib | 0.8973876 | 0.9901690 | 0.89739 | NA | NA |
| GNB1 | azd | 0.8976665 | 0.9901690 | 0.89767 | NA | NA |
| SETD2 | afatinib | 0.8979054 | 0.9901690 | 0.89791 | NA | NA |
| EZH2 | imatinib | 0.8979601 | 0.9901690 | 0.89796 | NA | NA |
| EZH2 | neratinib | 0.8979687 | 0.9901690 | 0.89797 | NA | NA |
| NOTCH1 | neratinib | 0.8979859 | 0.9901690 | 0.89799 | NA | NA |
| DDIT3 | fluorouracil | 0.8980325 | 0.9901690 | 0.89803 | NA | NA |
| SMO | cabozantinib | 0.8988218 | 0.9901690 | 0.89882 | NA | NA |
| CXCR4 | imatinib | 0.8988463 | 0.9901690 | 0.89885 | NA | NA |
| SMO | lapatinib | 0.8990292 | 0.9901690 | 0.89903 | NA | NA |
| GATA1 | vandetanib | 0.8993971 | 0.9901690 | 0.89940 | NA | NA |
| PRPF8 | imatinib | 0.8995458 | 0.9901690 | 0.89955 | NA | NA |
| CYP19A1 | crizotinib | 0.8996262 | 0.9901690 | 0.89963 | NA | NA |
| GATA1 | ibrutinib | 0.8996914 | 0.9901690 | 0.89969 | NA | NA |
| IDH2 | sunitinib | 0.9001651 | 0.9901690 | 0.90017 | NA | NA |
| CEBPA | fulvestrant | 0.9003949 | 0.9901690 | 0.90039 | NA | NA |
| FLT3 | cyclophosphamide | 0.9009165 | 0.9901690 | 0.90092 | NA | NA |
| TP53 | imatinib | 0.9010883 | 0.9901690 | 0.90109 | NA | NA |
| NPM1 | belinostat | 0.9011013 | 0.9901690 | 0.90110 | NA | NA |
| ERBB4 | neratinib | 0.9011809 | 0.9901690 | 0.90118 | NA | NA |
| NOTCH1 | gefitinib | 0.9031224 | 0.9919912 | 0.90312 | NA | NA |
| IDH2 | temozolomide | 0.9035358 | 0.9921344 | 0.90354 | NA | NA |
| IDH1 | gefitinib | 0.9049664 | 0.9928310 | 0.90497 | NA | NA |
| SF3B1 | fluorouracil | 0.9050933 | 0.9928310 | 0.90509 | NA | NA |
| JAK3 | selumetinib | 0.9055879 | 0.9928310 | 0.90559 | NA | NA |
| SETD2 | trametinib | 0.9058139 | 0.9928310 | 0.90581 | NA | NA |
| RPL10 | ruxolitinib | 0.9059576 | 0.9928310 | 0.90596 | NA | NA |
| JAK3 | azd | 0.9060871 | 0.9928310 | 0.90609 | NA | NA |
| WHSC1 | neratinib | 0.9064544 | 0.9928310 | 0.90645 | NA | NA |
| TPMT | vemurafenib | 0.9065616 | 0.9928310 | 0.90656 | NA | NA |
| SH2B3 | crizotinib | 0.9067196 | 0.9928310 | 0.90672 | NA | NA |
| ESR1 | crizotinib | 0.9085657 | 0.9931862 | 0.90857 | NA | NA |
| JAK2 | dasatinib | 0.9093889 | 0.9931862 | 0.90939 | NA | NA |
| ESR1 | cyclophosphamide | 0.9094059 | 0.9931862 | 0.90941 | NA | NA |
| FGFR3 | ruxolitinib | 0.9104004 | 0.9931862 | 0.91040 | NA | NA |
| EZH2 | dasatinib | 0.9104821 | 0.9931862 | 0.91048 | NA | NA |
| NRAS | dasatinib | 0.9112650 | 0.9931862 | 0.91127 | NA | NA |
| RET | olaparib | 0.9112727 | 0.9931862 | 0.91127 | NA | NA |
| ATM | sunitinib | 0.9116286 | 0.9931862 | 0.91163 | NA | NA |
| ETV6 | lapatinib | 0.9116653 | 0.9931862 | 0.91167 | NA | NA |
| DNMT3A | fulvestrant | 0.9118771 | 0.9931862 | 0.91188 | NA | NA |
| FGFR2 | ibrutinib | 0.9119707 | 0.9931862 | 0.91197 | NA | NA |
| PTCH1 | vandetanib | 0.9121958 | 0.9931862 | 0.91220 | NA | NA |
| JAK2 | fluorouracil | 0.9122887 | 0.9931862 | 0.91229 | NA | NA |
| SF3B1 | afatinib | 0.9126648 | 0.9931862 | 0.91266 | NA | NA |
| CTCF | ruxolitinib | 0.9127056 | 0.9931862 | 0.91271 | NA | NA |
| PRPF40B | trametinib | 0.9130833 | 0.9931862 | 0.91308 | NA | NA |
| CALR | neratinib | 0.9131151 | 0.9931862 | 0.91312 | NA | NA |
| MAP2K2 | ruxolitinib | 0.9139936 | 0.9931862 | 0.91399 | NA | NA |
| PTCH1 | ruxolitinib | 0.9145576 | 0.9931862 | 0.91456 | NA | NA |
| FGFR1 | imatinib | 0.9147300 | 0.9931862 | 0.91473 | NA | NA |
| MPL | lapatinib | 0.9148092 | 0.9931862 | 0.91481 | NA | NA |
| PDGFB | lapatinib | 0.9150133 | 0.9931862 | 0.91501 | NA | NA |
| GATA2 | erlotinib | 0.9150198 | 0.9931862 | 0.91502 | NA | NA |
| PAX8 | dasatinib | 0.9151131 | 0.9931862 | 0.91511 | NA | NA |
| SF3B1 | regorafenib | 0.9151696 | 0.9931862 | 0.91517 | NA | NA |
| ASXL1 | dasatinib | 0.9152073 | 0.9931862 | 0.91521 | NA | NA |
| PDCD1 | afatinib | 0.9153046 | 0.9931862 | 0.91530 | NA | NA |
| PIK3CA | fulvestrant | 0.9164663 | 0.9931862 | 0.91647 | NA | NA |
| CDK4 | belinostat | 0.9164906 | 0.9931862 | 0.91649 | NA | NA |
| AKT1 | dabrafenib | 0.9165171 | 0.9931862 | 0.91652 | NA | NA |
| DPYD | pazopanib | 0.9171346 | 0.9931862 | 0.91713 | NA | NA |
| AKT3 | sunitinib | 0.9176482 | 0.9931862 | 0.91765 | NA | NA |
| ROS1 | fluorouracil | 0.9179969 | 0.9931862 | 0.91800 | NA | NA |
| FBXW7 | sunitinib | 0.9181264 | 0.9931862 | 0.91813 | NA | NA |
| PRPF8 | fulvestrant | 0.9181909 | 0.9931862 | 0.91819 | NA | NA |
| ERBB4 | ibrutinib | 0.9182459 | 0.9931862 | 0.91825 | NA | NA |
| STAT3 | olaparib | 0.9184964 | 0.9931862 | 0.91850 | NA | NA |
| PDGFRA | olaparib | 0.9187781 | 0.9931862 | 0.91878 | NA | NA |
| GNAS | azd | 0.9189541 | 0.9931862 | 0.91895 | NA | NA |
| EGFR | neratinib | 0.9192244 | 0.9931862 | 0.91922 | NA | NA |
| DDIT3 | vemurafenib | 0.9192306 | 0.9931862 | 0.91923 | NA | NA |
| IKZF1 | regorafenib | 0.9194406 | 0.9931862 | 0.91944 | NA | NA |
| PTCH1 | cyclophosphamide | 0.9194906 | 0.9931862 | 0.91949 | NA | NA |
| CDK6 | crizotinib | 0.9196852 | 0.9931862 | 0.91969 | NA | NA |
| IL7R | gefitinib | 0.9203635 | 0.9931862 | 0.92036 | NA | NA |
| GNB1 | pazopanib | 0.9205719 | 0.9931862 | 0.92057 | NA | NA |
| TSC2 | ibrutinib | 0.9206937 | 0.9931862 | 0.92069 | NA | NA |
| NT5C2 | crizotinib | 0.9211815 | 0.9931862 | 0.92118 | NA | NA |
| PDGFB | cyclophosphamide | 0.9213531 | 0.9931862 | 0.92135 | NA | NA |
| SETBP1 | imatinib | 0.9215378 | 0.9931862 | 0.92154 | NA | NA |
| ESR1 | selumetinib | 0.9216779 | 0.9931862 | 0.92168 | NA | NA |
| MYD88 | cyclophosphamide | 0.9220687 | 0.9931862 | 0.92207 | NA | NA |
| CYP19A1 | trametinib | 0.9221480 | 0.9931862 | 0.92215 | NA | NA |
| UGT1A1 | belinostat | 0.9223455 | 0.9931862 | 0.92235 | NA | NA |
| JAK2 | neratinib | 0.9230054 | 0.9932228 | 0.92301 | NA | NA |
| SSX1 | ibrutinib | 0.9231222 | 0.9932228 | 0.92312 | NA | NA |
| BCOR | cyclophosphamide | 0.9232296 | 0.9932228 | 0.92323 | NA | NA |
| PDCD1 | neratinib | 0.9236462 | 0.9933661 | 0.92365 | NA | NA |
| ESR1 | belinostat | 0.9247735 | 0.9935595 | 0.92477 | NA | NA |
| SF1 | vandetanib | 0.9253818 | 0.9935595 | 0.92538 | NA | NA |
| STAG2 | gefitinib | 0.9254803 | 0.9935595 | 0.92548 | NA | NA |
| EZH2 | cyclophosphamide | 0.9256457 | 0.9935595 | 0.92565 | NA | NA |
| PDGFRA | belinostat | 0.9258624 | 0.9935595 | 0.92586 | NA | NA |
| EGFR | pazopanib | 0.9261994 | 0.9935595 | 0.92620 | NA | NA |
| DDIT3 | olaparib | 0.9263339 | 0.9935595 | 0.92633 | NA | NA |
| MAP2K1 | selumetinib | 0.9267489 | 0.9935595 | 0.92675 | NA | NA |
| BRCA2 | nilotinib | 0.9267694 | 0.9935595 | 0.92677 | NA | NA |
| UGT1A1 | vandetanib | 0.9276534 | 0.9935595 | 0.92765 | NA | NA |
| PRPF8 | sunitinib | 0.9277772 | 0.9935595 | 0.92778 | NA | NA |
| BTK | pazopanib | 0.9281695 | 0.9935595 | 0.92817 | NA | NA |
| CXCR4 | trametinib | 0.9282956 | 0.9935595 | 0.92830 | NA | NA |
| GATA3 | belinostat | 0.9283758 | 0.9935595 | 0.92838 | NA | NA |
| IDH1 | ruxolitinib | 0.9283856 | 0.9935595 | 0.92839 | NA | NA |
| MDM2 | imatinib | 0.9286632 | 0.9935595 | 0.92866 | NA | NA |
| PIGA | neratinib | 0.9287545 | 0.9935595 | 0.92875 | NA | NA |
| PTEN | vemurafenib | 0.9289285 | 0.9935595 | 0.92893 | NA | NA |
| JAK1 | pazopanib | 0.9297271 | 0.9937771 | 0.92973 | NA | NA |
| GATA2 | afatinib | 0.9301179 | 0.9937771 | 0.93012 | NA | NA |
| AR | lapatinib | 0.9302671 | 0.9937771 | 0.93027 | NA | NA |
| FLT3 | vandetanib | 0.9305740 | 0.9937771 | 0.93057 | NA | NA |
| CTLA4 | dasatinib | 0.9318118 | 0.9937771 | 0.93181 | NA | NA |
| CREBBP | lapatinib | 0.9318908 | 0.9937771 | 0.93189 | NA | NA |
| EGF | cyclophosphamide | 0.9323090 | 0.9937771 | 0.93231 | NA | NA |
| NCOA2 | temozolomide | 0.9323112 | 0.9937771 | 0.93231 | NA | NA |
| XPO1 | pazopanib | 0.9324116 | 0.9937771 | 0.93241 | NA | NA |
| NOTCH2 | belinostat | 0.9326123 | 0.9937771 | 0.93261 | NA | NA |
| CBL | vandetanib | 0.9326788 | 0.9937771 | 0.93268 | NA | NA |
| CEBPA | gefitinib | 0.9327284 | 0.9937771 | 0.93273 | NA | NA |
| AKT1 | belinostat | 0.9332615 | 0.9937771 | 0.93326 | NA | NA |
| SMC1A | belinostat | 0.9334362 | 0.9937771 | 0.93344 | NA | NA |
| SH2B3 | neratinib | 0.9336448 | 0.9937771 | 0.93364 | NA | NA |
| AKT2 | ibrutinib | 0.9339351 | 0.9937771 | 0.93394 | NA | NA |
| PRPF8 | olaparib | 0.9339520 | 0.9937771 | 0.93395 | NA | NA |
| BRCA1 | afatinib | 0.9350732 | 0.9938801 | 0.93507 | NA | NA |
| ERBB3 | ibrutinib | 0.9351931 | 0.9938801 | 0.93519 | NA | NA |
| RIT1 | sunitinib | 0.9358763 | 0.9938801 | 0.93588 | NA | NA |
| CBL | temozolomide | 0.9359277 | 0.9938801 | 0.93593 | NA | NA |
| SMC1A | pazopanib | 0.9360098 | 0.9938801 | 0.93601 | NA | NA |
| IDH2 | ibrutinib | 0.9361769 | 0.9938801 | 0.93618 | NA | NA |
| CD79B | afatinib | 0.9362534 | 0.9938801 | 0.93625 | NA | NA |
| EGFR | crizotinib | 0.9363173 | 0.9938801 | 0.93632 | NA | NA |
| FGFR3 | cyclophosphamide | 0.9369354 | 0.9939304 | 0.93694 | NA | NA |
| AKT2 | pazopanib | 0.9370564 | 0.9939304 | 0.93706 | NA | NA |
| NOTCH2 | crizotinib | 0.9372154 | 0.9939304 | 0.93722 | NA | NA |
| SMC3 | ruxolitinib | 0.9375989 | 0.9940363 | 0.93760 | NA | NA |
| IDH2 | fluorouracil | 0.9380996 | 0.9942665 | 0.93810 | NA | NA |
| SSX1 | vemurafenib | 0.9396473 | 0.9952513 | 0.93965 | NA | NA |
| STAG2 | crizotinib | 0.9397555 | 0.9952513 | 0.93976 | NA | NA |
| CDK6 | ruxolitinib | 0.9401740 | 0.9952513 | 0.94017 | NA | NA |
| CTLA4 | crizotinib | 0.9407221 | 0.9952513 | 0.94072 | NA | NA |
| CBLB | belinostat | 0.9407517 | 0.9952513 | 0.94075 | NA | NA |
| MYD88 | olaparib | 0.9407553 | 0.9952513 | 0.94076 | NA | NA |
| NOTCH1 | cyclophosphamide | 0.9414847 | 0.9952513 | 0.94148 | NA | NA |
| ERBB2 | sunitinib | 0.9415781 | 0.9952513 | 0.94158 | NA | NA |
| BCORL1 | fluorouracil | 0.9415844 | 0.9952513 | 0.94158 | NA | NA |
| FLT3 | ruxolitinib | 0.9427873 | 0.9959329 | 0.94279 | NA | NA |
| AKT3 | neratinib | 0.9427975 | 0.9959329 | 0.94280 | NA | NA |
| GNAS | crizotinib | 0.9437095 | 0.9962945 | 0.94371 | NA | NA |
| FGFR3 | azd | 0.9439579 | 0.9962945 | 0.94396 | NA | NA |
| CBLB | gefitinib | 0.9443486 | 0.9962945 | 0.94435 | NA | NA |
| IKZF1 | dabrafenib | 0.9445109 | 0.9962945 | 0.94451 | NA | NA |
| IDH2 | regorafenib | 0.9449361 | 0.9962945 | 0.94494 | NA | NA |
| EED | trametinib | 0.9451365 | 0.9962945 | 0.94514 | NA | NA |
| BCOR | crizotinib | 0.9453853 | 0.9962945 | 0.94539 | NA | NA |
| SRSF2 | azd | 0.9457703 | 0.9962945 | 0.94577 | NA | NA |
| SSX1 | azd | 0.9457703 | 0.9962945 | 0.94577 | NA | NA |
| U2AF1 | imatinib | 0.9459823 | 0.9962945 | 0.94598 | NA | NA |
| FGFR1 | cabozantinib | 0.9465185 | 0.9965597 | 0.94652 | NA | NA |
| SF3B1 | lapatinib | 0.9473691 | 0.9966036 | 0.94737 | NA | NA |
| KMT2A | olaparib | 0.9477038 | 0.9966036 | 0.94770 | NA | NA |
| ASXL1 | afatinib | 0.9477215 | 0.9966036 | 0.94772 | NA | NA |
| GATA3 | regorafenib | 0.9477853 | 0.9966036 | 0.94779 | NA | NA |
| CTLA4 | selumetinib | 0.9479818 | 0.9966036 | 0.94798 | NA | NA |
| CBLB | afatinib | 0.9482971 | 0.9966360 | 0.94830 | NA | NA |
| MAP2K2 | lapatinib | 0.9490923 | 0.9970065 | 0.94909 | NA | NA |
| CYP19A1 | gefitinib | 0.9492185 | 0.9970065 | 0.94922 | NA | NA |
| ROS1 | neratinib | 0.9510033 | 0.9974133 | 0.95100 | NA | NA |
| GATA1 | trametinib | 0.9511799 | 0.9974133 | 0.95118 | NA | NA |
| CDC73 | crizotinib | 0.9512685 | 0.9974133 | 0.95127 | NA | NA |
| RUNX1 | belinostat | 0.9516637 | 0.9974133 | 0.95166 | NA | NA |
| MYCN | gefitinib | 0.9527789 | 0.9974133 | 0.95278 | NA | NA |
| FLCN | neratinib | 0.9536094 | 0.9974133 | 0.95361 | NA | NA |
| GNB1 | lapatinib | 0.9537834 | 0.9974133 | 0.95378 | NA | NA |
| SETD2 | vandetanib | 0.9539574 | 0.9974133 | 0.95396 | NA | NA |
| EML4 | belinostat | 0.9539855 | 0.9974133 | 0.95399 | NA | NA |
| PRPF40B | belinostat | 0.9540890 | 0.9974133 | 0.95409 | NA | NA |
| NPM1 | imatinib | 0.9542718 | 0.9974133 | 0.95427 | NA | NA |
| EZH2 | trametinib | 0.9543379 | 0.9974133 | 0.95434 | NA | NA |
| FBXW7 | regorafenib | 0.9544165 | 0.9974133 | 0.95442 | NA | NA |
| PHF6 | lapatinib | 0.9545753 | 0.9974133 | 0.95458 | NA | NA |
| RUNX1 | vandetanib | 0.9545957 | 0.9974133 | 0.95460 | NA | NA |
| NOTCH2 | ruxolitinib | 0.9549655 | 0.9974133 | 0.95497 | NA | NA |
| CSF3R | erlotinib | 0.9552814 | 0.9974133 | 0.95528 | NA | NA |
| EML4 | fluorouracil | 0.9557093 | 0.9974133 | 0.95571 | NA | NA |
| KIT | fluorouracil | 0.9561079 | 0.9974133 | 0.95611 | NA | NA |
| CXCR4 | erlotinib | 0.9561802 | 0.9974133 | 0.95618 | NA | NA |
| G6PD | ruxolitinib | 0.9561889 | 0.9974133 | 0.95619 | NA | NA |
| PDGFRB | olaparib | 0.9563573 | 0.9974133 | 0.95636 | NA | NA |
| ABL1 | lapatinib | 0.9564785 | 0.9974133 | 0.95648 | NA | NA |
| STAG2 | imatinib | 0.9565871 | 0.9974133 | 0.95659 | NA | NA |
| ALK | sunitinib | 0.9567200 | 0.9974133 | 0.95672 | NA | NA |
| BTK | lapatinib | 0.9573567 | 0.9974624 | 0.95736 | NA | NA |
| EML4 | olaparib | 0.9575189 | 0.9974624 | 0.95752 | NA | NA |
| XPO1 | lapatinib | 0.9580799 | 0.9974624 | 0.95808 | NA | NA |
| PRPF8 | trametinib | 0.9590313 | 0.9974624 | 0.95903 | NA | NA |
| CBLB | fluorouracil | 0.9594755 | 0.9974624 | 0.95948 | NA | NA |
| CTCF | ibrutinib | 0.9594929 | 0.9974624 | 0.95949 | NA | NA |
| CD274 | gefitinib | 0.9597297 | 0.9974624 | 0.95973 | NA | NA |
| CRLF2 | fulvestrant | 0.9598588 | 0.9974624 | 0.95986 | NA | NA |
| SRSF2 | pazopanib | 0.9606497 | 0.9974624 | 0.96065 | NA | NA |
| EGF | belinostat | 0.9616768 | 0.9974624 | 0.96168 | NA | NA |
| BCOR | lapatinib | 0.9618340 | 0.9974624 | 0.96183 | NA | NA |
| PDGFB | temozolomide | 0.9628530 | 0.9974624 | 0.96285 | NA | NA |
| IL7R | fluorouracil | 0.9644846 | 0.9974624 | 0.96448 | NA | NA |
| MYD88 | erlotinib | 0.9646182 | 0.9974624 | 0.96462 | NA | NA |
| DDIT3 | nilotinib | 0.9647471 | 0.9974624 | 0.96475 | NA | NA |
| PDCD1 | regorafenib | 0.9648149 | 0.9974624 | 0.96481 | NA | NA |
| PTCH1 | ibrutinib | 0.9649617 | 0.9974624 | 0.96496 | NA | NA |
| IL7R | imatinib | 0.9651681 | 0.9974624 | 0.96517 | NA | NA |
| EZH2 | pazopanib | 0.9654333 | 0.9974624 | 0.96543 | NA | NA |
| TSC1 | cyclophosphamide | 0.9655074 | 0.9974624 | 0.96551 | NA | NA |
| EML4 | vemurafenib | 0.9655257 | 0.9974624 | 0.96553 | NA | NA |
| ESR1 | dabrafenib | 0.9659108 | 0.9974624 | 0.96591 | NA | NA |
| GATA1 | ruxolitinib | 0.9659289 | 0.9974624 | 0.96593 | NA | NA |
| DNMT3A | regorafenib | 0.9661684 | 0.9974624 | 0.96617 | NA | NA |
| FLCN | ruxolitinib | 0.9662498 | 0.9974624 | 0.96625 | NA | NA |
| EZH2 | vemurafenib | 0.9665676 | 0.9974624 | 0.96657 | NA | NA |
| BRCA1 | dabrafenib | 0.9666621 | 0.9974624 | 0.96666 | NA | NA |
| KIT | fulvestrant | 0.9667212 | 0.9974624 | 0.96672 | NA | NA |
| PHF6 | trametinib | 0.9667334 | 0.9974624 | 0.96673 | NA | NA |
| XPO1 | crizotinib | 0.9667804 | 0.9974624 | 0.96678 | NA | NA |
| EED | azd | 0.9667815 | 0.9974624 | 0.96678 | NA | NA |
| NCOA2 | selumetinib | 0.9669234 | 0.9974624 | 0.96692 | NA | NA |
| ERBB2 | olaparib | 0.9669476 | 0.9974624 | 0.96695 | NA | NA |
| CALR | belinostat | 0.9669583 | 0.9974624 | 0.96696 | NA | NA |
| AKT1 | nilotinib | 0.9672155 | 0.9974624 | 0.96722 | NA | NA |
| FGFR2 | afatinib | 0.9675251 | 0.9974624 | 0.96753 | NA | NA |
| EML4 | dasatinib | 0.9678093 | 0.9974624 | 0.96781 | NA | NA |
| MYCN | regorafenib | 0.9684122 | 0.9974624 | 0.96841 | NA | NA |
| ROS1 | imatinib | 0.9684583 | 0.9974624 | 0.96846 | NA | NA |
| ERBB2 | crizotinib | 0.9689644 | 0.9974624 | 0.96896 | NA | NA |
| IKZF1 | selumetinib | 0.9704495 | 0.9974624 | 0.97045 | NA | NA |
| CBL | belinostat | 0.9706806 | 0.9974624 | 0.97068 | NA | NA |
| TSC1 | gefitinib | 0.9708568 | 0.9974624 | 0.97086 | NA | NA |
| SF1 | cyclophosphamide | 0.9717760 | 0.9974624 | 0.97178 | NA | NA |
| SRSF2 | imatinib | 0.9719927 | 0.9974624 | 0.97199 | NA | NA |
| DDIT3 | regorafenib | 0.9725031 | 0.9974624 | 0.97250 | NA | NA |
| PRPF8 | ibrutinib | 0.9726461 | 0.9974624 | 0.97265 | NA | NA |
| CBL | ruxolitinib | 0.9727074 | 0.9974624 | 0.97271 | NA | NA |
| DPYD | olaparib | 0.9728161 | 0.9974624 | 0.97282 | NA | NA |
| DPYD | ibrutinib | 0.9736731 | 0.9974624 | 0.97367 | NA | NA |
| CEBPA | vemurafenib | 0.9737661 | 0.9974624 | 0.97377 | NA | NA |
| GNB1 | imatinib | 0.9748158 | 0.9974624 | 0.97482 | NA | NA |
| CREBBP | cabozantinib | 0.9751680 | 0.9974624 | 0.97517 | NA | NA |
| XPO1 | cyclophosphamide | 0.9753028 | 0.9974624 | 0.97530 | NA | NA |
| BTK | sunitinib | 0.9753496 | 0.9974624 | 0.97535 | NA | NA |
| G6PD | crizotinib | 0.9756109 | 0.9974624 | 0.97561 | NA | NA |
| MDM2 | fluorouracil | 0.9760470 | 0.9974624 | 0.97605 | NA | NA |
| AR | nilotinib | 0.9764453 | 0.9974624 | 0.97645 | NA | NA |
| DDIT3 | crizotinib | 0.9765232 | 0.9974624 | 0.97652 | NA | NA |
| UGT1A1 | fulvestrant | 0.9765345 | 0.9974624 | 0.97653 | NA | NA |
| STAG2 | cyclophosphamide | 0.9766301 | 0.9974624 | 0.97663 | NA | NA |
| MDM2 | belinostat | 0.9766324 | 0.9974624 | 0.97663 | NA | NA |
| FGFR3 | sunitinib | 0.9772450 | 0.9974624 | 0.97724 | NA | NA |
| IKZF1 | cabozantinib | 0.9773678 | 0.9974624 | 0.97737 | NA | NA |
| EZH2 | temozolomide | 0.9773752 | 0.9974624 | 0.97738 | NA | NA |
| MDM2 | azd | 0.9774556 | 0.9974624 | 0.97746 | NA | NA |
| CBL | vemurafenib | 0.9774758 | 0.9974624 | 0.97748 | NA | NA |
| SMC3 | pazopanib | 0.9774832 | 0.9974624 | 0.97748 | NA | NA |
| ATM | crizotinib | 0.9777348 | 0.9974624 | 0.97773 | NA | NA |
| PAX5 | lapatinib | 0.9778607 | 0.9974624 | 0.97786 | NA | NA |
| FGFR2 | vemurafenib | 0.9778868 | 0.9974624 | 0.97789 | NA | NA |
| DPYD | dasatinib | 0.9779403 | 0.9974624 | 0.97794 | NA | NA |
| SMC1A | sunitinib | 0.9782705 | 0.9974624 | 0.97827 | NA | NA |
| CBLB | azd | 0.9783756 | 0.9974624 | 0.97838 | NA | NA |
| IDH1 | vandetanib | 0.9787934 | 0.9974624 | 0.97879 | NA | NA |
| G6PD | imatinib | 0.9790505 | 0.9974624 | 0.97905 | NA | NA |
| PDGFRA | cyclophosphamide | 0.9793614 | 0.9974624 | 0.97936 | NA | NA |
| CTCF | pazopanib | 0.9794886 | 0.9974624 | 0.97949 | NA | NA |
| MAP2K1 | afatinib | 0.9795938 | 0.9974624 | 0.97959 | NA | NA |
| SF3B1 | cyclophosphamide | 0.9798172 | 0.9974624 | 0.97982 | NA | NA |
| IKZF1 | sunitinib | 0.9798183 | 0.9974624 | 0.97982 | NA | NA |
| JAK1 | ruxolitinib | 0.9810934 | 0.9984704 | 0.98109 | NA | NA |
| HRAS | gefitinib | 0.9823491 | 0.9994583 | 0.98235 | NA | NA |
| ERBB3 | erlotinib | 0.9832344 | 0.9998174 | 0.98323 | NA | NA |
| WT1 | imatinib | 0.9832727 | 0.9998174 | 0.98327 | NA | NA |
| PAX5 | trametinib | 0.9843143 | 1.0000000 | 0.98431 | NA | NA |
| PAX8 | olaparib | 0.9845620 | 1.0000000 | 0.98456 | NA | NA |
| CBL | afatinib | 0.9852397 | 1.0000000 | 0.98524 | NA | NA |
| PRPF40B | crizotinib | 0.9855953 | 1.0000000 | 0.98560 | NA | NA |
| MDM2 | dabrafenib | 0.9857206 | 1.0000000 | 0.98572 | NA | NA |
| XPO1 | selumetinib | 0.9858655 | 1.0000000 | 0.98587 | NA | NA |
| JAK3 | belinostat | 0.9859752 | 1.0000000 | 0.98598 | NA | NA |
| U2AF1 | crizotinib | 0.9865012 | 1.0000000 | 0.98650 | NA | NA |
| PAX8 | neratinib | 0.9866863 | 1.0000000 | 0.98669 | NA | NA |
| BRAF | gefitinib | 0.9871832 | 1.0000000 | 0.98718 | NA | NA |
| FGFR3 | cabozantinib | 0.9879399 | 1.0000000 | 0.98794 | NA | NA |
| CDK6 | ibrutinib | 0.9879518 | 1.0000000 | 0.98795 | NA | NA |
| CTCF | lapatinib | 0.9879662 | 1.0000000 | 0.98797 | NA | NA |
| CBLB | ruxolitinib | 0.9884828 | 1.0000000 | 0.98848 | NA | NA |
| BRCA1 | crizotinib | 0.9886434 | 1.0000000 | 0.98864 | NA | NA |
| CD274 | neratinib | 0.9887228 | 1.0000000 | 0.98872 | NA | NA |
| KIT | temozolomide | 0.9895199 | 1.0000000 | 0.98952 | NA | NA |
| RET | dabrafenib | 0.9896121 | 1.0000000 | 0.98961 | NA | NA |
| FLT3 | crizotinib | 0.9896386 | 1.0000000 | 0.98964 | NA | NA |
| BRAF | sunitinib | 0.9897961 | 1.0000000 | 0.98980 | NA | NA |
| WT1 | sunitinib | 0.9898986 | 1.0000000 | 0.98990 | NA | NA |
| STAG2 | temozolomide | 0.9902967 | 1.0000000 | 0.99030 | NA | NA |
| STAG2 | vemurafenib | 0.9904545 | 1.0000000 | 0.99045 | NA | NA |
| ETV6 | regorafenib | 0.9912002 | 1.0000000 | 0.99120 | NA | NA |
| DDIT3 | selumetinib | 0.9916042 | 1.0000000 | 0.99160 | NA | NA |
| CSF3R | sunitinib | 0.9917743 | 1.0000000 | 0.99177 | NA | NA |
| SMO | sunitinib | 0.9917820 | 1.0000000 | 0.99178 | NA | NA |
| EGF | crizotinib | 0.9920321 | 1.0000000 | 0.99203 | NA | NA |
| STAT3 | dabrafenib | 0.9920667 | 1.0000000 | 0.99207 | NA | NA |
| RUNX1 | afatinib | 0.9923135 | 1.0000000 | 0.99231 | NA | NA |
| PRPF8 | azd | 0.9929652 | 1.0000000 | 0.99297 | NA | NA |
| NCOA2 | fluorouracil | 0.9943555 | 1.0000000 | 0.99436 | NA | NA |
| CDK4 | fluorouracil | 0.9946043 | 1.0000000 | 0.99460 | NA | NA |
| CDC73 | cyclophosphamide | 0.9950218 | 1.0000000 | 0.99502 | NA | NA |
| AR | vandetanib | 0.9953796 | 1.0000000 | 0.99538 | NA | NA |
| NPM1 | afatinib | 0.9954026 | 1.0000000 | 0.99540 | NA | NA |
| VHL | dasatinib | 0.9955844 | 1.0000000 | 0.99558 | NA | NA |
| MAP2K2 | neratinib | 0.9959548 | 1.0000000 | 0.99595 | NA | NA |
| ETV6 | dasatinib | 0.9960355 | 1.0000000 | 0.99604 | NA | NA |
| GATA3 | imatinib | 0.9964441 | 1.0000000 | 0.99644 | NA | NA |
| MYCN | dabrafenib | 0.9968376 | 1.0000000 | 0.99684 | NA | NA |
| NT5C2 | belinostat | 0.9968944 | 1.0000000 | 0.99689 | NA | NA |
| AKT3 | cyclophosphamide | 0.9970280 | 1.0000000 | 0.99703 | NA | NA |
| KMT2A | trametinib | 0.9973656 | 1.0000000 | 0.99737 | NA | NA |
| PTEN | cyclophosphamide | 0.9974631 | 1.0000000 | 0.99746 | NA | NA |
| KIT | ruxolitinib | 0.9977843 | 1.0000000 | 0.99778 | NA | NA |
| UGT1A1 | dasatinib | 0.9980158 | 1.0000000 | 0.99802 | NA | NA |
| GNA11 | fluorouracil | 0.9983479 | 1.0000000 | 0.99835 | NA | NA |
| IKZF1 | ibrutinib | 0.9985223 | 1.0000000 | 0.99852 | NA | NA |
| NT5C2 | dasatinib | 0.9985337 | 1.0000000 | 0.99853 | NA | NA |
| AKT3 | cabozantinib | 0.9986095 | 1.0000000 | 0.99861 | NA | NA |
| EZH2 | vandetanib | 0.9991178 | 1.0000000 | 0.99912 | NA | NA |
| EED | selumetinib | 0.9992472 | 1.0000000 | 0.99925 | NA | NA |
| AR | dasatinib | 0.9996814 | 1.0000000 | 0.99968 | NA | NA |
| FANCL | vandetanib | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| FANCL | ibrutinib | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| SF3B1 | neratinib | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| SRSF2 | dasatinib | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
ctrp_signif_lvlA_ByDrug <- readRDS("./data_munging/rds/ctrp_signif_lvlA_ByDrug.rds")
ctrp_signif_lvlA_ByDrug_all <- rbindlist(ctrp_signif_lvlA_ByDrug, use.names = TRUE)
ctrp_signif_lvlA_ByDrug_all <- ctrp_signif_lvlA_ByDrug_all[order(ctrp_signif_lvlA_ByDrug_all$p.adj),]
knitr::kable(ctrp_signif_lvlA_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: by-drug Wilcoxon test results for Level A point mutations, (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| KRAS | trametinib | 0.0000000 | 0.0000011 | 8.5e-09 | **** | **** |
| BRAF | trametinib | 0.0001576 | 0.0102447 | 0.00016 | *** |
|
| BRAF | dabrafenib | 0.0001234 | 0.0161618 | 0.00012 | *** |
|
| CDKN2A | trametinib | 0.0003927 | 0.0170174 | 0.00039 | *** |
|
| PTEN | belinostat | 0.0002105 | 0.0275704 | 0.00021 | *** |
|
| BCORL1 | temozolomide | 0.0003147 | 0.0412289 | 0.00031 | *** |
|
| TP53 | docetaxel | 0.0004703 | 0.0436874 | 0.00047 | *** |
|
| CDKN2A | docetaxel | 0.0006721 | 0.0436874 | 0.00067 | *** |
|
| PDGFRB | cabozantinib | 0.0005036 | 0.0659694 | 0.0005 | *** | NA |
| PIK3CA | docetaxel | 0.0023604 | 0.1022847 | 0.00236 | ** | NA |
| EZH2 | bosutinib monohydrate | 0.0011913 | 0.1548657 | 0.0012 | ** | NA |
| PDGFRB | tretinoin | 0.0032063 | 0.2164264 | 0.0032 | ** | NA |
| XPO1 | tretinoin | 0.0033296 | 0.2164264 | 0.0033 | ** | NA |
| KRAS | palbociclib | 0.0017081 | 0.2237674 | 0.0017 | ** | NA |
| NCOA2 | temozolomide | 0.0057459 | 0.2308994 | 0.00575 | ** | NA |
| GNAS | temozolomide | 0.0072122 | 0.2308994 | 0.00721 | ** | NA |
| TSC1 | temozolomide | 0.0073262 | 0.2308994 | 0.00733 | ** | NA |
| WHSC1 | temozolomide | 0.0104370 | 0.2308994 | 0.01044 |
|
NA |
| ETV6 | temozolomide | 0.0105755 | 0.2308994 | 0.01058 |
|
NA |
| ROS1 | cabozantinib | 0.0037056 | 0.2427151 | 0.0037 | ** | NA |
| NRAS | trametinib | 0.0075575 | 0.2456199 | 0.00756 | ** | NA |
| JAK1 | temozolomide | 0.0139643 | 0.2613316 | 0.01396 |
|
NA |
| VHL | gefitinib | 0.0020451 | 0.2658686 | 0.0020 | ** | NA |
| DNMT3A | temozolomide | 0.0163008 | 0.2669262 | 0.01630 |
|
NA |
| CTNNB1 | temozolomide | 0.0219771 | 0.2727138 | 0.02198 |
|
NA |
| CTCF | temozolomide | 0.0242740 | 0.2727138 | 0.02427 |
|
NA |
| VHL | temozolomide | 0.0253591 | 0.2727138 | 0.02536 |
|
NA |
| AR | temozolomide | 0.0274000 | 0.2727138 | 0.02740 |
|
NA |
| GNAQ | temozolomide | 0.0282137 | 0.2727138 | 0.02821 |
|
NA |
| CALR | temozolomide | 0.0292063 | 0.2727138 | 0.02921 |
|
NA |
| IKZF1 | temozolomide | 0.0321740 | 0.2727138 | 0.03217 |
|
NA |
| IL7R | temozolomide | 0.0343195 | 0.2727138 | 0.03432 |
|
NA |
| XPO1 | temozolomide | 0.0353903 | 0.2727138 | 0.03539 |
|
NA |
| ERBB3 | temozolomide | 0.0387034 | 0.2732555 | 0.03870 |
|
NA |
| NOTCH2 | temozolomide | 0.0404672 | 0.2732555 | 0.04047 |
|
NA |
| EZH2 | temozolomide | 0.0417184 | 0.2732555 | 0.04172 |
|
NA |
| PDCD1 | temozolomide | 0.0440126 | 0.2745547 | 0.04401 |
|
NA |
| SSX1 | temozolomide | 0.0487651 | 0.2865197 | 0.04877 |
|
NA |
| TPMT | temozolomide | 0.0503050 | 0.2865197 | 0.05030 | NA | NA |
| SETBP1 | temozolomide | 0.0526678 | 0.2874785 | 0.05267 | NA | NA |
| CDKN2A | palbociclib | 0.0077157 | 0.2961566 | 0.0077 | ** | NA |
| ALK | palbociclib | 0.0089754 | 0.2961566 | 0.0090 | ** | NA |
| SETBP1 | palbociclib | 0.0102198 | 0.2961566 | 0.0102 |
|
NA |
| CREBBP | palbociclib | 0.0129659 | 0.2961566 | 0.0130 |
|
NA |
| TP53 | palbociclib | 0.0135644 | 0.2961566 | 0.0136 |
|
NA |
| TET2 | temozolomide | 0.0678581 | 0.3414027 | 0.06786 | NA | NA |
| FGFR3 | temozolomide | 0.0685390 | 0.3414027 | 0.06854 | NA | NA |
| STAG2 | temozolomide | 0.0703654 | 0.3414027 | 0.07037 | NA | NA |
| SMO | temozolomide | 0.0771994 | 0.3611829 | 0.07720 | NA | NA |
| EGF | gefitinib | 0.0056307 | 0.3615114 | 0.0056 | ** | NA |
| NOTCH1 | gefitinib | 0.0083426 | 0.3615114 | 0.0083 | ** | NA |
| NOTCH2 | gefitinib | 0.0154450 | 0.3649982 | 0.0154 |
|
NA |
| FGFR3 | gefitinib | 0.0163800 | 0.3649982 | 0.0164 |
|
NA |
| TP53 | gefitinib | 0.0171497 | 0.3649982 | 0.0171 |
|
NA |
| ABL1 | gefitinib | 0.0196537 | 0.3649982 | 0.0197 |
|
NA |
| SMC3 | tretinoin | 0.0138983 | 0.3692445 | 0.0139 |
|
NA |
| NOTCH2 | tretinoin | 0.0152457 | 0.3692445 | 0.0152 |
|
NA |
| ZRSR2 | tretinoin | 0.0162776 | 0.3692445 | 0.0163 |
|
NA |
| BRCA1 | tretinoin | 0.0170421 | 0.3692445 | 0.0170 |
|
NA |
| MAP2K1 | tretinoin | 0.0288016 | 0.3746647 | 0.0288 |
|
NA |
| GNAQ | tretinoin | 0.0312954 | 0.3746647 | 0.0313 |
|
NA |
| AR | tretinoin | 0.0321095 | 0.3746647 | 0.0321 |
|
NA |
| EZH2 | tretinoin | 0.0330076 | 0.3746647 | 0.0330 |
|
NA |
| NPM1 | tretinoin | 0.0355459 | 0.3746647 | 0.0355 |
|
NA |
| FANCL | tretinoin | 0.0383049 | 0.3746647 | 0.0383 |
|
NA |
| TSC1 | tretinoin | 0.0414817 | 0.3746647 | 0.0415 |
|
NA |
| CDC73 | tretinoin | 0.0420071 | 0.3746647 | 0.0420 |
|
NA |
| GNAS | tretinoin | 0.0432305 | 0.3746647 | 0.0432 |
|
NA |
| CD274 | temozolomide | 0.0837166 | 0.3781679 | 0.08372 | NA | NA |
| CD79B | temozolomide | 0.0884961 | 0.3806075 | 0.08850 | NA | NA |
| PRPF40B | temozolomide | 0.0965946 | 0.3806075 | 0.09659 | NA | NA |
| NOTCH1 | temozolomide | 0.0980228 | 0.3806075 | 0.09802 | NA | NA |
| SMC3 | temozolomide | 0.0984456 | 0.3806075 | 0.09845 | NA | NA |
| MAP2K1 | temozolomide | 0.0987836 | 0.3806075 | 0.09878 | NA | NA |
| ATM | tretinoin | 0.0517302 | 0.4031994 | 0.0517 | NA | NA |
| SF3B1 | tretinoin | 0.0527261 | 0.4031994 | 0.0527 | NA | NA |
| CALR | dabrafenib | 0.0081373 | 0.4055764 | 0.00814 | ** | NA |
| NOTCH2 | dabrafenib | 0.0122810 | 0.4055764 | 0.01228 |
|
NA |
| XPO1 | dabrafenib | 0.0123840 | 0.4055764 | 0.01238 |
|
NA |
| TPMT | cabozantinib | 0.0218657 | 0.4056922 | 0.0219 |
|
NA |
| SH2B3 | cabozantinib | 0.0231792 | 0.4056922 | 0.0232 |
|
NA |
| DNAJB1 | cabozantinib | 0.0250495 | 0.4056922 | 0.0250 |
|
NA |
| FLT3 | cabozantinib | 0.0283979 | 0.4056922 | 0.0284 |
|
NA |
| TET2 | cabozantinib | 0.0296182 | 0.4056922 | 0.0296 |
|
NA |
| MAP2K2 | cabozantinib | 0.0302155 | 0.4056922 | 0.0302 |
|
NA |
| KMT2A | cabozantinib | 0.0319699 | 0.4056922 | 0.0320 |
|
NA |
| ZRSR2 | cabozantinib | 0.0342010 | 0.4056922 | 0.0342 |
|
NA |
| PHF6 | cabozantinib | 0.0380544 | 0.4056922 | 0.0381 |
|
NA |
| SETBP1 | cabozantinib | 0.0422020 | 0.4056922 | 0.0422 |
|
NA |
| ABL1 | cabozantinib | 0.0433477 | 0.4056922 | 0.0433 |
|
NA |
| CTNNB1 | cabozantinib | 0.0433564 | 0.4056922 | 0.0434 |
|
NA |
| ROS1 | trametinib | 0.0160528 | 0.4082794 | 0.01605 |
|
NA |
| CDK6 | trametinib | 0.0198135 | 0.4082794 | 0.01981 |
|
NA |
| SF3B1 | trametinib | 0.0228964 | 0.4082794 | 0.02290 |
|
NA |
| UGT1A1 | trametinib | 0.0274916 | 0.4082794 | 0.02749 |
|
NA |
| GATA2 | trametinib | 0.0282655 | 0.4082794 | 0.02827 |
|
NA |
| AKT2 | temozolomide | 0.1148997 | 0.4201641 | 0.11490 | NA | NA |
| ESR1 | temozolomide | 0.1154649 | 0.4201641 | 0.11546 | NA | NA |
| DNAJB1 | trametinib | 0.0348374 | 0.4296196 | 0.03484 |
|
NA |
| NOTCH1 | trametinib | 0.0408364 | 0.4296196 | 0.04084 |
|
NA |
| AKT3 | trametinib | 0.0423852 | 0.4296196 | 0.04239 |
|
NA |
| IDH1 | trametinib | 0.0480714 | 0.4296196 | 0.04807 |
|
NA |
| ZRSR2 | trametinib | 0.0485098 | 0.4296196 | 0.04851 |
|
NA |
| CALR | trametinib | 0.0553623 | 0.4296196 | 0.05536 | NA | NA |
| JAK3 | trametinib | 0.0579978 | 0.4296196 | 0.05800 | NA | NA |
| TP53 | trametinib | 0.0601194 | 0.4296196 | 0.06012 | NA | NA |
| ETV6 | trametinib | 0.0619050 | 0.4296196 | 0.06190 | NA | NA |
| PDCD1 | trametinib | 0.0627906 | 0.4296196 | 0.06279 | NA | NA |
| EZH2 | cabozantinib | 0.0549646 | 0.4358681 | 0.0550 | NA | NA |
| PTEN | cabozantinib | 0.0616827 | 0.4358681 | 0.0617 | NA | NA |
| WHSC1 | cabozantinib | 0.0636458 | 0.4358681 | 0.0636 | NA | NA |
| PTCH1 | cabozantinib | 0.0650780 | 0.4358681 | 0.0651 | NA | NA |
| NRAS | cabozantinib | 0.0660514 | 0.4358681 | 0.0661 | NA | NA |
| EML4 | cabozantinib | 0.0665447 | 0.4358681 | 0.0665 | NA | NA |
| RAD21 | cabozantinib | 0.0702610 | 0.4382946 | 0.0703 | NA | NA |
| PIK3CA | cabozantinib | 0.0738778 | 0.4399086 | 0.0739 | NA | NA |
| NOTCH1 | afatinib | 0.0065209 | 0.4471019 | 0.0065 | ** | NA |
| VHL | afatinib | 0.0079992 | 0.4471019 | 0.0080 | ** | NA |
| EGF | afatinib | 0.0156979 | 0.4471019 | 0.0157 |
|
NA |
| PIK3CA | afatinib | 0.0170969 | 0.4471019 | 0.0171 |
|
NA |
| ERBB2 | afatinib | 0.0171962 | 0.4471019 | 0.0172 |
|
NA |
| STAT3 | tretinoin | 0.0621330 | 0.4487384 | 0.0621 | NA | NA |
| ERBB2 | temozolomide | 0.1311049 | 0.4521498 | 0.13110 | NA | NA |
| IDH2 | temozolomide | 0.1311580 | 0.4521498 | 0.13116 | NA | NA |
| SMC3 | cabozantinib | 0.0794697 | 0.4526318 | 0.0795 | NA | NA |
| RPL10 | cabozantinib | 0.0850440 | 0.4532310 | 0.0850 | NA | NA |
| FBXW7 | cabozantinib | 0.0914621 | 0.4532310 | 0.0915 | NA | NA |
| CTLA4 | cabozantinib | 0.0933469 | 0.4532310 | 0.0933 | NA | NA |
| IDH2 | cabozantinib | 0.0934140 | 0.4532310 | 0.0934 | NA | NA |
| JAK1 | cabozantinib | 0.0992758 | 0.4536172 | 0.0993 | NA | NA |
| JAK2 | cabozantinib | 0.1004191 | 0.4536172 | 0.1004 | NA | NA |
| EED | temozolomide | 0.1353524 | 0.4536628 | 0.13535 | NA | NA |
| GNB1 | temozolomide | 0.1386197 | 0.4536628 | 0.13862 | NA | NA |
| CDC73 | temozolomide | 0.1419861 | 0.4536628 | 0.14199 | NA | NA |
| IL7R | tretinoin | 0.0766084 | 0.4599481 | 0.0766 | NA | NA |
| CSF3R | tretinoin | 0.0822956 | 0.4599481 | 0.0823 | NA | NA |
| SMO | tretinoin | 0.0848756 | 0.4599481 | 0.0849 | NA | NA |
| RPL10 | tretinoin | 0.0862479 | 0.4599481 | 0.0862 | NA | NA |
| UGT1A1 | tretinoin | 0.0911112 | 0.4599481 | 0.0911 | NA | NA |
| BRCA2 | tretinoin | 0.0916313 | 0.4599481 | 0.0916 | NA | NA |
| TPMT | tretinoin | 0.0957413 | 0.4599481 | 0.0957 | NA | NA |
| CTLA4 | tretinoin | 0.0990569 | 0.4599481 | 0.0991 | NA | NA |
| MYCN | tretinoin | 0.1019536 | 0.4599481 | 0.1020 | NA | NA |
| ETV6 | tretinoin | 0.1021380 | 0.4599481 | 0.1021 | NA | NA |
| PTEN | tretinoin | 0.1038671 | 0.4599481 | 0.1039 | NA | NA |
| TSC2 | tretinoin | 0.1061419 | 0.4599481 | 0.1061 | NA | NA |
| RUNX1 | tretinoin | 0.1125899 | 0.4616724 | 0.1126 | NA | NA |
| ROS1 | tretinoin | 0.1136424 | 0.4616724 | 0.1136 | NA | NA |
| GNB1 | ruxolitinib | 0.0035419 | 0.4639873 | 0.0035 | ** | NA |
| NRAS | imatinib | 0.0040262 | 0.4670344 | 0.004 | ** | NA |
| KIT | trametinib | 0.0733706 | 0.4671724 | 0.07337 | NA | NA |
| CDC73 | trametinib | 0.0754663 | 0.4671724 | 0.07547 | NA | NA |
| CD274 | cabozantinib | 0.1100504 | 0.4673779 | 0.1101 | NA | NA |
| FGFR2 | cabozantinib | 0.1132666 | 0.4673779 | 0.1133 | NA | NA |
| MDM2 | cabozantinib | 0.1141686 | 0.4673779 | 0.1142 | NA | NA |
| PDGFRA | tretinoin | 0.1216752 | 0.4705311 | 0.1217 | NA | NA |
| KIT | tretinoin | 0.1249785 | 0.4705311 | 0.1250 | NA | NA |
| NCOA2 | tretinoin | 0.1266814 | 0.4705311 | 0.1267 | NA | NA |
| PRPF8 | temozolomide | 0.1540934 | 0.4806246 | 0.15409 | NA | NA |
| PAX5 | cabozantinib | 0.1242237 | 0.4822894 | 0.1242 | NA | NA |
| TP53 | cabozantinib | 0.1336110 | 0.4822894 | 0.1336 | NA | NA |
| PTPN11 | cabozantinib | 0.1354785 | 0.4822894 | 0.1355 | NA | NA |
| PDGFRA | cabozantinib | 0.1407290 | 0.4822894 | 0.1407 | NA | NA |
| KIT | cabozantinib | 0.1434514 | 0.4822894 | 0.1435 | NA | NA |
| KRAS | cabozantinib | 0.1437272 | 0.4822894 | 0.1437 | NA | NA |
| BCOR | cabozantinib | 0.1489401 | 0.4822894 | 0.1489 | NA | NA |
| CRLF2 | cabozantinib | 0.1490076 | 0.4822894 | 0.1490 | NA | NA |
| ERBB4 | cabozantinib | 0.1509455 | 0.4822894 | 0.1509 | NA | NA |
| TSC2 | temozolomide | 0.1628876 | 0.4916012 | 0.16289 | NA | NA |
| RUNX1 | temozolomide | 0.1651179 | 0.4916012 | 0.16512 | NA | NA |
| JAK2 | trametinib | 0.0900127 | 0.4967736 | 0.09001 | NA | NA |
| SETBP1 | trametinib | 0.0962877 | 0.4967736 | 0.09629 | NA | NA |
| FGFR2 | trametinib | 0.0984897 | 0.4967736 | 0.09849 | NA | NA |
| WT1 | trametinib | 0.1003839 | 0.4967736 | 0.10038 | NA | NA |
| XPO1 | trametinib | 0.1015015 | 0.4967736 | 0.10150 | NA | NA |
| MYD88 | trametinib | 0.1042757 | 0.4967736 | 0.10428 | NA | NA |
| ABL1 | trametinib | 0.1069974 | 0.4967736 | 0.10700 | NA | NA |
| NRAS | afatinib | 0.0229960 | 0.4982469 | 0.0230 |
|
NA |
| AKT3 | temozolomide | 0.1716414 | 0.4996672 | 0.17164 | NA | NA |
| KRAS | pazopanib | 0.0043870 | 0.5041844 | 0.0044 | ** | NA |
| ABL1 | pazopanib | 0.0076975 | 0.5041844 | 0.0077 | ** | NA |
| FBXW7 | temozolomide | 0.1799955 | 0.5125960 | 0.18000 | NA | NA |
| CTLA4 | temozolomide | 0.1841506 | 0.5132710 | 0.18415 | NA | NA |
| AKT3 | docetaxel | 0.0158279 | 0.5144068 | 0.01583 |
|
NA |
| PAX5 | temozolomide | 0.1887930 | 0.5152476 | 0.18879 | NA | NA |
| GNB1 | cabozantinib | 0.1658940 | 0.5174314 | 0.1659 | NA | NA |
| RUNX1 | docetaxel | 0.0229958 | 0.5238674 | 0.02300 |
|
NA |
| MGMT | docetaxel | 0.0241785 | 0.5238674 | 0.02418 |
|
NA |
| CTNNB1 | ruxolitinib | 0.0173719 | 0.5335616 | 0.0174 |
|
NA |
| PAX8 | ruxolitinib | 0.0184880 | 0.5335616 | 0.0185 |
|
NA |
| MAP2K1 | ruxolitinib | 0.0186366 | 0.5335616 | 0.0186 |
|
NA |
| EZH2 | ruxolitinib | 0.0258155 | 0.5335616 | 0.0258 |
|
NA |
| PIK3CA | ruxolitinib | 0.0312550 | 0.5335616 | 0.0313 |
|
NA |
| WHSC1 | ruxolitinib | 0.0467507 | 0.5335616 | 0.0468 |
|
NA |
| RAD21 | ruxolitinib | 0.0481399 | 0.5335616 | 0.0481 |
|
NA |
| BCORL1 | ruxolitinib | 0.0528280 | 0.5335616 | 0.0528 | NA | NA |
| NCOA2 | ruxolitinib | 0.0550670 | 0.5335616 | 0.0551 | NA | NA |
| JAK1 | ruxolitinib | 0.0561915 | 0.5335616 | 0.0562 | NA | NA |
| CALR | ruxolitinib | 0.0572486 | 0.5335616 | 0.0572 | NA | NA |
| U2AF1 | ruxolitinib | 0.0579826 | 0.5335616 | 0.0580 | NA | NA |
| CDKN2A | ruxolitinib | 0.0596793 | 0.5335616 | 0.0597 | NA | NA |
| PDGFB | ruxolitinib | 0.0653257 | 0.5335616 | 0.0653 | NA | NA |
| ABL1 | ruxolitinib | 0.0661262 | 0.5335616 | 0.0661 | NA | NA |
| CYP19A1 | ruxolitinib | 0.0692408 | 0.5335616 | 0.0692 | NA | NA |
| NPM1 | cabozantinib | 0.1781069 | 0.5335830 | 0.1781 | NA | NA |
| SF1 | cabozantinib | 0.1792187 | 0.5335830 | 0.1792 | NA | NA |
| PAX8 | cabozantinib | 0.1865583 | 0.5338266 | 0.1866 | NA | NA |
| MPL | cabozantinib | 0.1896077 | 0.5338266 | 0.1896 | NA | NA |
| MGMT | cabozantinib | 0.1946541 | 0.5338266 | 0.1947 | NA | NA |
| SETD2 | cabozantinib | 0.1995660 | 0.5338266 | 0.1996 | NA | NA |
| GNAS | cabozantinib | 0.1996756 | 0.5338266 | 0.1997 | NA | NA |
| CREBBP | temozolomide | 0.2063925 | 0.5358048 | 0.20639 | NA | NA |
| GATA3 | temozolomide | 0.2077388 | 0.5358048 | 0.20774 | NA | NA |
| JAK2 | temozolomide | 0.2108300 | 0.5358048 | 0.21083 | NA | NA |
| RAD21 | temozolomide | 0.2154867 | 0.5358048 | 0.21549 | NA | NA |
| PTCH1 | temozolomide | 0.2167760 | 0.5358048 | 0.21678 | NA | NA |
| PML | temozolomide | 0.2217712 | 0.5380004 | 0.22177 | NA | NA |
| FBXW7 | gefitinib | 0.0379174 | 0.5407797 | 0.0379 |
|
NA |
| PIGA | gefitinib | 0.0386253 | 0.5407797 | 0.0386 |
|
NA |
| SF3B1 | gefitinib | 0.0415984 | 0.5407797 | 0.0416 |
|
NA |
| KRAS | dabrafenib | 0.0278924 | 0.5413795 | 0.02789 |
|
NA |
| AKT3 | dabrafenib | 0.0282407 | 0.5413795 | 0.02824 |
|
NA |
| DNAJB1 | dabrafenib | 0.0289287 | 0.5413795 | 0.02893 |
|
NA |
| NCOA2 | crizotinib | 0.0046821 | 0.5431240 | 0.0047 | ** | NA |
| CALR | cabozantinib | 0.2096259 | 0.5481521 | 0.2096 | NA | NA |
| U2AF1 | cabozantinib | 0.2134027 | 0.5481521 | 0.2134 | NA | NA |
| GNB1 | trametinib | 0.1250888 | 0.5484924 | 0.12509 | NA | NA |
| FGFR1 | trametinib | 0.1292149 | 0.5484924 | 0.12921 | NA | NA |
| PDGFRA | trametinib | 0.1350935 | 0.5484924 | 0.13509 | NA | NA |
| ALK | trametinib | 0.1385711 | 0.5484924 | 0.13857 | NA | NA |
| TSC2 | trametinib | 0.1392327 | 0.5484924 | 0.13923 | NA | NA |
| MPL | temozolomide | 0.2305412 | 0.5491073 | 0.23054 | NA | NA |
| GATA3 | trametinib | 0.1446868 | 0.5519437 | 0.14469 | NA | NA |
| IL7R | trametinib | 0.1502552 | 0.5519437 | 0.15026 | NA | NA |
| GNAQ | trametinib | 0.1547547 | 0.5519437 | 0.15475 | NA | NA |
| WHSC1 | trametinib | 0.1570917 | 0.5519437 | 0.15709 | NA | NA |
| NT5C2 | cabozantinib | 0.2249494 | 0.5563923 | 0.2249 | NA | NA |
| HRAS | cabozantinib | 0.2251053 | 0.5563923 | 0.2251 | NA | NA |
| GNB1 | alectinib | 0.0042631 | 0.5584650 | 0.0043 | ** | NA |
| BCOR | trametinib | 0.1650504 | 0.5646463 | 0.16505 | NA | NA |
| CD79B | tretinoin | 0.1643471 | 0.5708883 | 0.1643 | NA | NA |
| TP53 | tretinoin | 0.1673997 | 0.5708883 | 0.1674 | NA | NA |
| PDGFB | tretinoin | 0.1722109 | 0.5708883 | 0.1722 | NA | NA |
| PTCH1 | tretinoin | 0.1733580 | 0.5708883 | 0.1734 | NA | NA |
| EML4 | tretinoin | 0.1756579 | 0.5708883 | 0.1757 | NA | NA |
| CTNNB1 | docetaxel | 0.0356295 | 0.5709069 | 0.03563 |
|
NA |
| FGFR2 | docetaxel | 0.0408171 | 0.5709069 | 0.04082 |
|
NA |
| ATM | docetaxel | 0.0457127 | 0.5709069 | 0.04571 |
|
NA |
| CREBBP | docetaxel | 0.0462148 | 0.5709069 | 0.04621 |
|
NA |
| CRLF2 | docetaxel | 0.0483075 | 0.5709069 | 0.04831 |
|
NA |
| TSC1 | trametinib | 0.1714196 | 0.5713987 | 0.17142 | NA | NA |
| FGFR2 | temozolomide | 0.2455699 | 0.5744582 | 0.24557 | NA | NA |
| RAD21 | tretinoin | 0.1903979 | 0.5815114 | 0.1904 | NA | NA |
| IKZF1 | tretinoin | 0.1918545 | 0.5815114 | 0.1919 | NA | NA |
| CRLF2 | tretinoin | 0.1923461 | 0.5815114 | 0.1923 | NA | NA |
| CTCF | cabozantinib | 0.2443216 | 0.5868901 | 0.2443 | NA | NA |
| PDCD1 | cabozantinib | 0.2464043 | 0.5868901 | 0.2464 | NA | NA |
| PHF6 | tretinoin | 0.2045860 | 0.5899515 | 0.2046 | NA | NA |
| MDM2 | tretinoin | 0.2059902 | 0.5899515 | 0.2060 | NA | NA |
| CEBPA | tretinoin | 0.2087521 | 0.5899515 | 0.2088 | NA | NA |
| TP53 | temozolomide | 0.2572528 | 0.5912301 | 0.25725 | NA | NA |
| JAK2 | dabrafenib | 0.0362699 | 0.5939194 | 0.03627 |
|
NA |
| PIK3CA | gefitinib | 0.0505049 | 0.5968763 | 0.0505 | NA | NA |
| EGF | cabozantinib | 0.2557242 | 0.5982121 | 0.2557 | NA | NA |
| MDM2 | docetaxel | 0.0557127 | 0.6035542 | 0.05571 | NA | NA |
| FLCN | ruxolitinib | 0.0877965 | 0.6115893 | 0.0878 | NA | NA |
| RPL10 | ruxolitinib | 0.0887038 | 0.6115893 | 0.0887 | NA | NA |
| DNMT3A | cabozantinib | 0.2687536 | 0.6129888 | 0.2688 | NA | NA |
| GATA1 | cabozantinib | 0.2722065 | 0.6129888 | 0.2722 | NA | NA |
| RUNX1 | cabozantinib | 0.2760789 | 0.6129888 | 0.2761 | NA | NA |
| KRAS | tretinoin | 0.2237016 | 0.6146500 | 0.2237 | NA | NA |
| TET2 | tretinoin | 0.2269477 | 0.6146500 | 0.2269 | NA | NA |
| NPM1 | temozolomide | 0.2747200 | 0.6204884 | 0.27472 | NA | NA |
| MYD88 | ruxolitinib | 0.0954788 | 0.6253862 | 0.0955 | NA | NA |
| NT5C2 | tretinoin | 0.2358069 | 0.6256102 | 0.2358 | NA | NA |
| ERBB3 | cabozantinib | 0.2887403 | 0.6304163 | 0.2887 | NA | NA |
| GNAQ | docetaxel | 0.0658365 | 0.6323606 | 0.06584 | NA | NA |
| DNMT3A | docetaxel | 0.0692678 | 0.6323606 | 0.06927 | NA | NA |
| CDC73 | docetaxel | 0.0864333 | 0.6323606 | 0.08643 | NA | NA |
| PTEN | docetaxel | 0.0903770 | 0.6323606 | 0.09038 | NA | NA |
| WHSC1 | docetaxel | 0.0905119 | 0.6323606 | 0.09051 | NA | NA |
| ABL1 | docetaxel | 0.0918631 | 0.6323606 | 0.09186 | NA | NA |
| CBLB | docetaxel | 0.0924219 | 0.6323606 | 0.09242 | NA | NA |
| AKT2 | tretinoin | 0.2446468 | 0.6341008 | 0.2446 | NA | NA |
| ERBB3 | tretinoin | 0.2487626 | 0.6341008 | 0.2488 | NA | NA |
| HRAS | tretinoin | 0.2537166 | 0.6342916 | 0.2537 | NA | NA |
| CALR | tretinoin | 0.2599107 | 0.6375168 | 0.2599 | NA | NA |
| CBL | temozolomide | 0.2912507 | 0.6410298 | 0.29125 | NA | NA |
| SMC1A | temozolomide | 0.2977471 | 0.6410298 | 0.29775 | NA | NA |
| PIGA | temozolomide | 0.3013076 | 0.6410298 | 0.30131 | NA | NA |
| DNAJB1 | temozolomide | 0.3033881 | 0.6410298 | 0.30339 | NA | NA |
| UGT1A1 | afatinib | 0.0384529 | 0.6453715 | 0.0385 |
|
NA |
| CDKN2A | afatinib | 0.0397152 | 0.6453715 | 0.0397 |
|
NA |
| ERBB4 | temozolomide | 0.3115486 | 0.6478232 | 0.31155 | NA | NA |
| PAX5 | ruxolitinib | 0.1202681 | 0.6485243 | 0.1203 | NA | NA |
| TPMT | ruxolitinib | 0.1231531 | 0.6485243 | 0.1232 | NA | NA |
| RUNX1 | ruxolitinib | 0.1276182 | 0.6485243 | 0.1276 | NA | NA |
| JAK3 | ruxolitinib | 0.1351891 | 0.6485243 | 0.1352 | NA | NA |
| STAT3 | ruxolitinib | 0.1427439 | 0.6485243 | 0.1427 | NA | NA |
| FGFR1 | ruxolitinib | 0.1519639 | 0.6485243 | 0.1520 | NA | NA |
| ZRSR2 | ruxolitinib | 0.1522656 | 0.6485243 | 0.1523 | NA | NA |
| PRPF40B | ruxolitinib | 0.1533423 | 0.6485243 | 0.1533 | NA | NA |
| IKZF1 | ruxolitinib | 0.1536440 | 0.6485243 | 0.1536 | NA | NA |
| IL7R | ruxolitinib | 0.1543734 | 0.6485243 | 0.1544 | NA | NA |
| PTEN | ruxolitinib | 0.1566767 | 0.6485243 | 0.1567 | NA | NA |
| TET2 | ruxolitinib | 0.1663985 | 0.6485243 | 0.1664 | NA | NA |
| PTPN11 | ruxolitinib | 0.1682990 | 0.6485243 | 0.1683 | NA | NA |
| EED | ruxolitinib | 0.1723166 | 0.6485243 | 0.1723 | NA | NA |
| VHL | ruxolitinib | 0.1743680 | 0.6485243 | 0.1744 | NA | NA |
| CTCF | ruxolitinib | 0.1782204 | 0.6485243 | 0.1782 | NA | NA |
| EZH2 | imatinib | 0.0169779 | 0.6495160 | 0.017 |
|
NA |
| GNB1 | imatinib | 0.0252224 | 0.6495160 | 0.025 |
|
NA |
| ESR1 | imatinib | 0.0394429 | 0.6495160 | 0.039 |
|
NA |
| NCOA2 | imatinib | 0.0464638 | 0.6495160 | 0.046 |
|
NA |
| BCORL1 | imatinib | 0.0590039 | 0.6495160 | 0.059 | NA | NA |
| BCOR | imatinib | 0.0617869 | 0.6495160 | 0.062 | NA | NA |
| JAK3 | imatinib | 0.0632514 | 0.6495160 | 0.063 | NA | NA |
| FGFR2 | imatinib | 0.0731536 | 0.6495160 | 0.073 | NA | NA |
| DNAJB1 | imatinib | 0.0817584 | 0.6495160 | 0.082 | NA | NA |
| MDM2 | imatinib | 0.0872503 | 0.6495160 | 0.087 | NA | NA |
| VHL | imatinib | 0.0884277 | 0.6495160 | 0.088 | NA | NA |
| EML4 | imatinib | 0.0947179 | 0.6495160 | 0.095 | NA | NA |
| RPL10 | imatinib | 0.0953332 | 0.6495160 | 0.095 | NA | NA |
| FLT3 | imatinib | 0.0990080 | 0.6495160 | 0.099 | NA | NA |
| FLCN | imatinib | 0.1005378 | 0.6495160 | 0.101 | NA | NA |
| CYP19A1 | imatinib | 0.1086620 | 0.6495160 | 0.109 | NA | NA |
| BRCA2 | imatinib | 0.1174800 | 0.6495160 | 0.117 | NA | NA |
| PIGA | imatinib | 0.1236551 | 0.6495160 | 0.124 | NA | NA |
| RIT1 | imatinib | 0.1236551 | 0.6495160 | 0.124 | NA | NA |
| SMC1A | imatinib | 0.1238297 | 0.6495160 | 0.124 | NA | NA |
| ETV6 | imatinib | 0.1331229 | 0.6495160 | 0.133 | NA | NA |
| MAP2K1 | imatinib | 0.1429961 | 0.6495160 | 0.143 | NA | NA |
| ERBB3 | imatinib | 0.1453832 | 0.6495160 | 0.145 | NA | NA |
| EGF | imatinib | 0.1470992 | 0.6495160 | 0.147 | NA | NA |
| FANCL | imatinib | 0.1471141 | 0.6495160 | 0.147 | NA | NA |
| MET | imatinib | 0.1511805 | 0.6495160 | 0.151 | NA | NA |
| JAK2 | tretinoin | 0.2702044 | 0.6504920 | 0.2702 | NA | NA |
| DPYD | cabozantinib | 0.3047799 | 0.6545274 | 0.3048 | NA | NA |
| SRSF2 | tretinoin | 0.2812022 | 0.6569322 | 0.2812 | NA | NA |
| AKT3 | tretinoin | 0.2910595 | 0.6569322 | 0.2911 | NA | NA |
| ERBB2 | tretinoin | 0.3012993 | 0.6569322 | 0.3013 | NA | NA |
| BCORL1 | tretinoin | 0.3097124 | 0.6569322 | 0.3097 | NA | NA |
| BRAF | tretinoin | 0.3097622 | 0.6569322 | 0.3098 | NA | NA |
| WHSC1 | tretinoin | 0.3115987 | 0.6569322 | 0.3116 | NA | NA |
| MET | tretinoin | 0.3136957 | 0.6569322 | 0.3137 | NA | NA |
| NRAS | tretinoin | 0.3141618 | 0.6569322 | 0.3142 | NA | NA |
| SH2B3 | tretinoin | 0.3183595 | 0.6569322 | 0.3184 | NA | NA |
| GATA1 | temozolomide | 0.3232634 | 0.6616435 | 0.32326 | NA | NA |
| U2AF1 | temozolomide | 0.3282964 | 0.6616435 | 0.32830 | NA | NA |
| CD274 | ruxolitinib | 0.1870849 | 0.6623818 | 0.1871 | NA | NA |
| EZH2 | palbociclib | 0.0358492 | 0.6639872 | 0.0358 |
|
NA |
| GATA2 | palbociclib | 0.0420214 | 0.6639872 | 0.0420 |
|
NA |
| GATA3 | palbociclib | 0.0495673 | 0.6639872 | 0.0496 |
|
NA |
| U2AF1 | palbociclib | 0.0518080 | 0.6639872 | 0.0518 | NA | NA |
| CBLB | palbociclib | 0.0557547 | 0.6639872 | 0.0558 | NA | NA |
| CDK6 | cabozantinib | 0.3152330 | 0.6660569 | 0.3152 | NA | NA |
| NT5C2 | imatinib | 0.1629599 | 0.6677699 | 0.163 | NA | NA |
| STAG2 | imatinib | 0.1717038 | 0.6677699 | 0.172 | NA | NA |
| SF1 | imatinib | 0.1779288 | 0.6677699 | 0.178 | NA | NA |
| NPM1 | imatinib | 0.1935911 | 0.6677699 | 0.194 | NA | NA |
| PRPF40B | imatinib | 0.1984027 | 0.6677699 | 0.198 | NA | NA |
| ZRSR2 | imatinib | 0.1984027 | 0.6677699 | 0.198 | NA | NA |
| CD79B | imatinib | 0.2040208 | 0.6677699 | 0.204 | NA | NA |
| GNAQ | imatinib | 0.2040208 | 0.6677699 | 0.204 | NA | NA |
| CTNNB1 | imatinib | 0.2072389 | 0.6677699 | 0.207 | NA | NA |
| VHL | erlotinib | 0.0058080 | 0.6679176 | 0.0058 | ** | NA |
| BCOR | temozolomide | 0.3390158 | 0.6728951 | 0.33902 | NA | NA |
| PAX8 | docetaxel | 0.1054555 | 0.6738688 | 0.10546 | NA | NA |
| U2AF1 | docetaxel | 0.1088557 | 0.6738688 | 0.10886 | NA | NA |
| BRAF | ruxolitinib | 0.1976786 | 0.6771198 | 0.1977 | NA | NA |
| STAG2 | ruxolitinib | 0.2060015 | 0.6771198 | 0.2060 | NA | NA |
| MYCN | ruxolitinib | 0.2191911 | 0.6771198 | 0.2192 | NA | NA |
| TP53 | ruxolitinib | 0.2293455 | 0.6771198 | 0.2293 | NA | NA |
| ALK | ruxolitinib | 0.2294413 | 0.6771198 | 0.2294 | NA | NA |
| NRAS | ruxolitinib | 0.2306461 | 0.6771198 | 0.2306 | NA | NA |
| CEBPA | ruxolitinib | 0.2318168 | 0.6771198 | 0.2318 | NA | NA |
| G6PD | ruxolitinib | 0.2325984 | 0.6771198 | 0.2326 | NA | NA |
| JAK1 | tretinoin | 0.3338555 | 0.6781439 | 0.3339 | NA | NA |
| CTCF | imatinib | 0.2188316 | 0.6804247 | 0.219 | NA | NA |
| PAX5 | imatinib | 0.2228977 | 0.6804247 | 0.223 | NA | NA |
| ATM | temozolomide | 0.3484051 | 0.6812100 | 0.34841 | NA | NA |
| RPL10 | docetaxel | 0.1206554 | 0.6814448 | 0.12066 | NA | NA |
| SMO | docetaxel | 0.1208460 | 0.6814448 | 0.12085 | NA | NA |
| MYD88 | docetaxel | 0.1258052 | 0.6814448 | 0.12581 | NA | NA |
| VHL | lapatinib | 0.0058885 | 0.6830626 | 0.0059 | ** | NA |
| FLCN | cabozantinib | 0.3290045 | 0.6841204 | 0.3290 | NA | NA |
| BTK | tretinoin | 0.3447531 | 0.6860343 | 0.3448 | NA | NA |
| IDH2 | tretinoin | 0.3482943 | 0.6860343 | 0.3483 | NA | NA |
| CDK6 | pazopanib | 0.0157171 | 0.6863144 | 0.0157 |
|
NA |
| NPM1 | dabrafenib | 0.0506987 | 0.6877005 | 0.05070 | NA | NA |
| ERBB3 | dabrafenib | 0.0574180 | 0.6877005 | 0.05742 | NA | NA |
| TET2 | dabrafenib | 0.0577458 | 0.6877005 | 0.05775 | NA | NA |
| MAP2K1 | trametinib | 0.2151783 | 0.6898155 | 0.21518 | NA | NA |
| CBLB | trametinib | 0.2206325 | 0.6898155 | 0.22063 | NA | NA |
| U2AF1 | trametinib | 0.2247977 | 0.6898155 | 0.22480 | NA | NA |
| FGFR3 | trametinib | 0.2295042 | 0.6898155 | 0.22950 | NA | NA |
| CREBBP | trametinib | 0.2417435 | 0.6898155 | 0.24174 | NA | NA |
| CYP19A1 | trametinib | 0.2426959 | 0.6898155 | 0.24270 | NA | NA |
| DPYD | trametinib | 0.2458254 | 0.6898155 | 0.24583 | NA | NA |
| RET | trametinib | 0.2493948 | 0.6898155 | 0.24939 | NA | NA |
| SRSF2 | cabozantinib | 0.3392737 | 0.6944509 | 0.3393 | NA | NA |
| JAK1 | palbociclib | 0.0659376 | 0.6955119 | 0.0659 | NA | NA |
| SRSF2 | palbociclib | 0.0800824 | 0.6955119 | 0.0801 | NA | NA |
| EGF | palbociclib | 0.0817756 | 0.6955119 | 0.0818 | NA | NA |
| BTK | palbociclib | 0.0828013 | 0.6955119 | 0.0828 | NA | NA |
| RPL10 | palbociclib | 0.0873407 | 0.6955119 | 0.0873 | NA | NA |
| RET | palbociclib | 0.0983382 | 0.6955119 | 0.0983 | NA | NA |
| BRCA2 | palbociclib | 0.1027690 | 0.6955119 | 0.1028 | NA | NA |
| ZRSR2 | palbociclib | 0.1039936 | 0.6955119 | 0.1040 | NA | NA |
| BRAF | palbociclib | 0.1131136 | 0.6955119 | 0.1131 | NA | NA |
| FGFR1 | palbociclib | 0.1164096 | 0.6955119 | 0.1164 | NA | NA |
| VHL | palbociclib | 0.1197067 | 0.6955119 | 0.1197 | NA | NA |
| KMT2A | palbociclib | 0.1221128 | 0.6955119 | 0.1221 | NA | NA |
| CBLB | ruxolitinib | 0.2446656 | 0.6967651 | 0.2447 | NA | NA |
| GATA1 | imatinib | 0.2395896 | 0.7015219 | 0.240 | NA | NA |
| GATA3 | imatinib | 0.2473162 | 0.7015219 | 0.247 | NA | NA |
| PDGFB | imatinib | 0.2502352 | 0.7015219 | 0.250 | NA | NA |
| CALR | imatinib | 0.2539993 | 0.7015219 | 0.254 | NA | NA |
| RET | docetaxel | 0.1477981 | 0.7031832 | 0.14780 | NA | NA |
| CTCF | docetaxel | 0.1533534 | 0.7031832 | 0.15335 | NA | NA |
| NOTCH1 | docetaxel | 0.1690237 | 0.7031832 | 0.16902 | NA | NA |
| MAP2K1 | docetaxel | 0.1700087 | 0.7031832 | 0.17001 | NA | NA |
| ROS1 | docetaxel | 0.1704250 | 0.7031832 | 0.17043 | NA | NA |
| CALR | docetaxel | 0.1774390 | 0.7031832 | 0.17744 | NA | NA |
| JAK2 | docetaxel | 0.1783666 | 0.7031832 | 0.17837 | NA | NA |
| G6PD | docetaxel | 0.1822668 | 0.7031832 | 0.18227 | NA | NA |
| DDIT3 | docetaxel | 0.1899483 | 0.7031832 | 0.18995 | NA | NA |
| PDCD1 | docetaxel | 0.1924908 | 0.7031832 | 0.19249 | NA | NA |
| PHF6 | docetaxel | 0.1965851 | 0.7031832 | 0.19659 | NA | NA |
| TSC2 | docetaxel | 0.1988212 | 0.7031832 | 0.19882 | NA | NA |
| FGFR1 | docetaxel | 0.2138153 | 0.7031832 | 0.21382 | NA | NA |
| SF3B1 | docetaxel | 0.2143435 | 0.7031832 | 0.21434 | NA | NA |
| EGF | docetaxel | 0.2461603 | 0.7031832 | 0.24616 | NA | NA |
| GNA11 | docetaxel | 0.2485190 | 0.7031832 | 0.24852 | NA | NA |
| NPM1 | docetaxel | 0.2488101 | 0.7031832 | 0.24881 | NA | NA |
| IDH1 | docetaxel | 0.2558126 | 0.7031832 | 0.25581 | NA | NA |
| TPMT | docetaxel | 0.2626723 | 0.7031832 | 0.26267 | NA | NA |
| BRAF | docetaxel | 0.2666895 | 0.7031832 | 0.26669 | NA | NA |
| ZRSR2 | docetaxel | 0.2674973 | 0.7031832 | 0.26750 | NA | NA |
| KRAS | docetaxel | 0.2725554 | 0.7031832 | 0.27256 | NA | NA |
| EZH2 | docetaxel | 0.2774451 | 0.7031832 | 0.27745 | NA | NA |
| CTLA4 | docetaxel | 0.2788643 | 0.7031832 | 0.27886 | NA | NA |
| CD274 | docetaxel | 0.2805815 | 0.7031832 | 0.28058 | NA | NA |
| PDGFRB | docetaxel | 0.2818564 | 0.7031832 | 0.28186 | NA | NA |
| MPL | docetaxel | 0.2836659 | 0.7031832 | 0.28367 | NA | NA |
| JAK3 | docetaxel | 0.2865263 | 0.7031832 | 0.28653 | NA | NA |
| CXCR4 | docetaxel | 0.2866824 | 0.7031832 | 0.28668 | NA | NA |
| ERBB4 | imatinib | 0.2611044 | 0.7043747 | 0.261 | NA | NA |
| TPMT | dabrafenib | 0.0737570 | 0.7070530 | 0.07376 | NA | NA |
| IDH1 | dabrafenib | 0.0752645 | 0.7070530 | 0.07526 | NA | NA |
| RAD21 | dabrafenib | 0.0773282 | 0.7070530 | 0.07733 | NA | NA |
| NT5C2 | dabrafenib | 0.1005154 | 0.7070530 | 0.10052 | NA | NA |
| PHF6 | dabrafenib | 0.1087549 | 0.7070530 | 0.10875 | NA | NA |
| TSC2 | dabrafenib | 0.1118016 | 0.7070530 | 0.11180 | NA | NA |
| CBL | dabrafenib | 0.1130546 | 0.7070530 | 0.11305 | NA | NA |
| SETD2 | dabrafenib | 0.1138566 | 0.7070530 | 0.11386 | NA | NA |
| ATM | dabrafenib | 0.1159223 | 0.7070530 | 0.11592 | NA | NA |
| ALK | dabrafenib | 0.1254923 | 0.7070530 | 0.12549 | NA | NA |
| EGFR | dabrafenib | 0.1350723 | 0.7070530 | 0.13507 | NA | NA |
| MET | dabrafenib | 0.1361932 | 0.7070530 | 0.13619 | NA | NA |
| TP53 | dabrafenib | 0.1373973 | 0.7070530 | 0.13740 | NA | NA |
| CDC73 | dabrafenib | 0.1516303 | 0.7070530 | 0.15163 | NA | NA |
| CRLF2 | dabrafenib | 0.1520171 | 0.7070530 | 0.15202 | NA | NA |
| PDCD1 | dabrafenib | 0.1546264 | 0.7070530 | 0.15463 | NA | NA |
| ZRSR2 | dabrafenib | 0.1591476 | 0.7070530 | 0.15915 | NA | NA |
| CD79B | dabrafenib | 0.1596056 | 0.7070530 | 0.15961 | NA | NA |
| KMT2A | dabrafenib | 0.1680952 | 0.7070530 | 0.16810 | NA | NA |
| PIK3CA | dabrafenib | 0.1707493 | 0.7070530 | 0.17075 | NA | NA |
| EED | dabrafenib | 0.1727152 | 0.7070530 | 0.17272 | NA | NA |
| CDC73 | ponatinib | 0.0223079 | 0.7084349 | 0.022 |
|
NA |
| ERBB3 | ponatinib | 0.0344904 | 0.7084349 | 0.034 |
|
NA |
| DNAJB1 | ponatinib | 0.0447942 | 0.7084349 | 0.045 |
|
NA |
| FBXW7 | ponatinib | 0.0514651 | 0.7084349 | 0.051 | NA | NA |
| ABL1 | ponatinib | 0.0614896 | 0.7084349 | 0.061 | NA | NA |
| PIGA | ponatinib | 0.0621845 | 0.7084349 | 0.062 | NA | NA |
| CREBBP | ponatinib | 0.0643029 | 0.7084349 | 0.064 | NA | NA |
| SRSF2 | ponatinib | 0.0749201 | 0.7084349 | 0.075 | NA | NA |
| CSF3R | ponatinib | 0.0758595 | 0.7084349 | 0.076 | NA | NA |
| ASXL1 | ponatinib | 0.0806503 | 0.7084349 | 0.081 | NA | NA |
| FGFR2 | ponatinib | 0.0814419 | 0.7084349 | 0.081 | NA | NA |
| CTLA4 | ponatinib | 0.0856420 | 0.7084349 | 0.086 | NA | NA |
| RPL10 | ponatinib | 0.0860587 | 0.7084349 | 0.086 | NA | NA |
| CALR | ponatinib | 0.0929099 | 0.7084349 | 0.093 | NA | NA |
| IL7R | ponatinib | 0.0972285 | 0.7084349 | 0.097 | NA | NA |
| SH2B3 | ponatinib | 0.1023151 | 0.7084349 | 0.102 | NA | NA |
| CXCR4 | ponatinib | 0.1109241 | 0.7084349 | 0.111 | NA | NA |
| STAT3 | ponatinib | 0.1142358 | 0.7084349 | 0.114 | NA | NA |
| ROS1 | ponatinib | 0.1143242 | 0.7084349 | 0.114 | NA | NA |
| FANCL | ponatinib | 0.1174239 | 0.7084349 | 0.117 | NA | NA |
| EZH2 | ponatinib | 0.1193818 | 0.7084349 | 0.119 | NA | NA |
| CDK6 | ponatinib | 0.1216781 | 0.7084349 | 0.122 | NA | NA |
| CDKN2A | ponatinib | 0.1262284 | 0.7084349 | 0.126 | NA | NA |
| GNA11 | ponatinib | 0.1297896 | 0.7084349 | 0.130 | NA | NA |
| CDKN2A | temozolomide | 0.3683127 | 0.7095436 | 0.36831 | NA | NA |
| SETD2 | imatinib | 0.2695411 | 0.7106084 | 0.270 | NA | NA |
| ABL1 | afatinib | 0.0507264 | 0.7114784 | 0.0507 | NA | NA |
| CDK6 | afatinib | 0.0547291 | 0.7114784 | 0.0547 | NA | NA |
| U2AF1 | imatinib | 0.2938112 | 0.7119423 | 0.294 | NA | NA |
| UGT1A1 | imatinib | 0.2957214 | 0.7119423 | 0.296 | NA | NA |
| XPO1 | imatinib | 0.2979122 | 0.7119423 | 0.298 | NA | NA |
| BTK | imatinib | 0.2980109 | 0.7119423 | 0.298 | NA | NA |
| TSC1 | imatinib | 0.3108496 | 0.7119423 | 0.311 | NA | NA |
| PDGFRA | imatinib | 0.3143676 | 0.7119423 | 0.314 | NA | NA |
| ERBB2 | imatinib | 0.3160344 | 0.7119423 | 0.316 | NA | NA |
| SMC3 | imatinib | 0.3191465 | 0.7119423 | 0.319 | NA | NA |
| NOTCH2 | nilotinib | 0.0055404 | 0.7135301 | 0.0055 | ** | NA |
| RAD21 | nilotinib | 0.0135245 | 0.7135301 | 0.0135 |
|
NA |
| ETV6 | nilotinib | 0.0280075 | 0.7135301 | 0.0280 |
|
NA |
| GNAQ | nilotinib | 0.0300494 | 0.7135301 | 0.0300 |
|
NA |
| MAP2K1 | nilotinib | 0.0321453 | 0.7135301 | 0.0321 |
|
NA |
| CDC73 | nilotinib | 0.0329322 | 0.7135301 | 0.0329 |
|
NA |
| DPYD | temozolomide | 0.3822258 | 0.7153994 | 0.38223 | NA | NA |
| MDM2 | temozolomide | 0.3822745 | 0.7153994 | 0.38227 | NA | NA |
| BRCA2 | erlotinib | 0.0208851 | 0.7177003 | 0.0209 |
|
NA |
| WT1 | erlotinib | 0.0619633 | 0.7177003 | 0.0620 | NA | NA |
| CDK4 | erlotinib | 0.0672825 | 0.7177003 | 0.0673 | NA | NA |
| GNAS | erlotinib | 0.0775246 | 0.7177003 | 0.0775 | NA | NA |
| STAT3 | erlotinib | 0.0845539 | 0.7177003 | 0.0846 | NA | NA |
| FLT3 | erlotinib | 0.0848216 | 0.7177003 | 0.0848 | NA | NA |
| FBXW7 | erlotinib | 0.0858748 | 0.7177003 | 0.0859 | NA | NA |
| FGFR2 | erlotinib | 0.0905151 | 0.7177003 | 0.0905 | NA | NA |
| RPL10 | erlotinib | 0.0912646 | 0.7177003 | 0.0913 | NA | NA |
| ROS1 | erlotinib | 0.0943399 | 0.7177003 | 0.0943 | NA | NA |
| CRLF2 | erlotinib | 0.1091200 | 0.7177003 | 0.1091 | NA | NA |
| PRPF40B | erlotinib | 0.1140652 | 0.7177003 | 0.1141 | NA | NA |
| CBL | erlotinib | 0.1192013 | 0.7177003 | 0.1192 | NA | NA |
| MET | erlotinib | 0.1281272 | 0.7177003 | 0.1281 | NA | NA |
| MGMT | erlotinib | 0.1288089 | 0.7177003 | 0.1288 | NA | NA |
| FLCN | erlotinib | 0.1333236 | 0.7177003 | 0.1333 | NA | NA |
| CALR | erlotinib | 0.1340397 | 0.7177003 | 0.1340 | NA | NA |
| PAX8 | erlotinib | 0.1394332 | 0.7177003 | 0.1394 | NA | NA |
| FGFR1 | erlotinib | 0.1424666 | 0.7177003 | 0.1425 | NA | NA |
| PDGFB | erlotinib | 0.1449924 | 0.7177003 | 0.1450 | NA | NA |
| UGT1A1 | erlotinib | 0.1468898 | 0.7177003 | 0.1469 | NA | NA |
| ATM | erlotinib | 0.1547223 | 0.7177003 | 0.1547 | NA | NA |
| FGFR3 | erlotinib | 0.1556510 | 0.7177003 | 0.1557 | NA | NA |
| NRAS | erlotinib | 0.1660607 | 0.7177003 | 0.1661 | NA | NA |
| PAX5 | erlotinib | 0.1794822 | 0.7177003 | 0.1795 | NA | NA |
| PIGA | erlotinib | 0.1794822 | 0.7177003 | 0.1795 | NA | NA |
| NCOA2 | erlotinib | 0.1903671 | 0.7177003 | 0.1904 | NA | NA |
| EZH2 | erlotinib | 0.1974234 | 0.7177003 | 0.1974 | NA | NA |
| PDGFRB | erlotinib | 0.2028937 | 0.7177003 | 0.2029 | NA | NA |
| JAK1 | erlotinib | 0.2097544 | 0.7177003 | 0.2098 | NA | NA |
| NPM1 | erlotinib | 0.2158617 | 0.7177003 | 0.2159 | NA | NA |
| IL7R | erlotinib | 0.2186340 | 0.7177003 | 0.2186 | NA | NA |
| GATA2 | erlotinib | 0.2198677 | 0.7177003 | 0.2199 | NA | NA |
| RIT1 | erlotinib | 0.2253417 | 0.7177003 | 0.2253 | NA | NA |
| SMC1A | erlotinib | 0.2261745 | 0.7177003 | 0.2262 | NA | NA |
| FANCL | erlotinib | 0.2309123 | 0.7177003 | 0.2309 | NA | NA |
| IDH1 | nilotinib | 0.0386525 | 0.7178331 | 0.0387 |
|
NA |
| RAD21 | alectinib | 0.0435161 | 0.7190961 | 0.0435 |
|
NA |
| EML4 | alectinib | 0.0492773 | 0.7190961 | 0.0493 |
|
NA |
| RET | alectinib | 0.0609957 | 0.7190961 | 0.0610 | NA | NA |
| PDGFRA | alectinib | 0.0638924 | 0.7190961 | 0.0639 | NA | NA |
| SETBP1 | alectinib | 0.0668146 | 0.7190961 | 0.0668 | NA | NA |
| PTPN11 | alectinib | 0.0715010 | 0.7190961 | 0.0715 | NA | NA |
| NT5C2 | alectinib | 0.0850860 | 0.7190961 | 0.0851 | NA | NA |
| EZH2 | alectinib | 0.0868365 | 0.7190961 | 0.0868 | NA | NA |
| RPL10 | alectinib | 0.0868754 | 0.7190961 | 0.0869 | NA | NA |
| TPMT | alectinib | 0.0935866 | 0.7190961 | 0.0936 | NA | NA |
| CD274 | alectinib | 0.0945006 | 0.7190961 | 0.0945 | NA | NA |
| AKT3 | alectinib | 0.0987542 | 0.7190961 | 0.0988 | NA | NA |
| SMC3 | alectinib | 0.1109591 | 0.7190961 | 0.1110 | NA | NA |
| FLCN | alectinib | 0.1110717 | 0.7190961 | 0.1111 | NA | NA |
| FANCL | alectinib | 0.1248849 | 0.7190961 | 0.1249 | NA | NA |
| SETD2 | alectinib | 0.1283291 | 0.7190961 | 0.1283 | NA | NA |
| MAP2K1 | alectinib | 0.1306584 | 0.7190961 | 0.1307 | NA | NA |
| ASXL1 | alectinib | 0.1383344 | 0.7190961 | 0.1383 | NA | NA |
| EED | alectinib | 0.1407867 | 0.7190961 | 0.1408 | NA | NA |
| GNAQ | alectinib | 0.1418350 | 0.7190961 | 0.1418 | NA | NA |
| CTLA4 | alectinib | 0.1466805 | 0.7190961 | 0.1467 | NA | NA |
| G6PD | alectinib | 0.1491983 | 0.7190961 | 0.1492 | NA | NA |
| BRAF | alectinib | 0.1526449 | 0.7190961 | 0.1526 | NA | NA |
| IL7R | alectinib | 0.1558610 | 0.7190961 | 0.1559 | NA | NA |
| HRAS | alectinib | 0.1622969 | 0.7190961 | 0.1623 | NA | NA |
| DDIT3 | alectinib | 0.1687949 | 0.7190961 | 0.1688 | NA | NA |
| STAT3 | alectinib | 0.1812298 | 0.7190961 | 0.1812 | NA | NA |
| BRCA2 | alectinib | 0.1881297 | 0.7190961 | 0.1881 | NA | NA |
| CTNNB1 | alectinib | 0.1894137 | 0.7190961 | 0.1894 | NA | NA |
| PML | alectinib | 0.1950849 | 0.7190961 | 0.1951 | NA | NA |
| JAK1 | alectinib | 0.2001873 | 0.7190961 | 0.2002 | NA | NA |
| BCORL1 | alectinib | 0.2070853 | 0.7190961 | 0.2071 | NA | NA |
| GATA3 | alectinib | 0.2079277 | 0.7190961 | 0.2079 | NA | NA |
| PTEN | alectinib | 0.2092253 | 0.7190961 | 0.2092 | NA | NA |
| STAG2 | alectinib | 0.2144126 | 0.7190961 | 0.2144 | NA | NA |
| CEBPA | alectinib | 0.2230121 | 0.7190961 | 0.2230 | NA | NA |
| NPM1 | alectinib | 0.2246258 | 0.7190961 | 0.2246 | NA | NA |
| RIT1 | alectinib | 0.2291396 | 0.7190961 | 0.2291 | NA | NA |
| ROS1 | alectinib | 0.2335276 | 0.7190961 | 0.2335 | NA | NA |
| PDCD1 | alectinib | 0.2338858 | 0.7190961 | 0.2339 | NA | NA |
| JAK2 | alectinib | 0.2385373 | 0.7190961 | 0.2385 | NA | NA |
| TSC2 | alectinib | 0.2393143 | 0.7190961 | 0.2393 | NA | NA |
| VHL | alectinib | 0.2439120 | 0.7190961 | 0.2439 | NA | NA |
| ABL1 | alectinib | 0.2470177 | 0.7190961 | 0.2470 | NA | NA |
| PDGFRB | dabrafenib | 0.1895855 | 0.7211576 | 0.18959 | NA | NA |
| GNB1 | dabrafenib | 0.1924605 | 0.7211576 | 0.19246 | NA | NA |
| KIT | dabrafenib | 0.2027554 | 0.7211576 | 0.20276 | NA | NA |
| BCORL1 | dabrafenib | 0.2043963 | 0.7211576 | 0.20440 | NA | NA |
| CDK6 | dabrafenib | 0.2053813 | 0.7211576 | 0.20538 | NA | NA |
| GATA1 | dabrafenib | 0.2115052 | 0.7211576 | 0.21151 | NA | NA |
| EGF | dabrafenib | 0.2146958 | 0.7211576 | 0.21470 | NA | NA |
| GNAS | ponatinib | 0.1378710 | 0.7224438 | 0.138 | NA | NA |
| GATA2 | cabozantinib | 0.3602779 | 0.7230306 | 0.3603 | NA | NA |
| AR | cabozantinib | 0.3642750 | 0.7230306 | 0.3643 | NA | NA |
| MYCN | docetaxel | 0.3007324 | 0.7239855 | 0.30073 | NA | NA |
| RIT1 | tretinoin | 0.3778288 | 0.7268605 | 0.3778 | NA | NA |
| MPL | tretinoin | 0.3802579 | 0.7268605 | 0.3803 | NA | NA |
| AKT1 | tretinoin | 0.3944562 | 0.7268605 | 0.3945 | NA | NA |
| WT1 | tretinoin | 0.3981599 | 0.7268605 | 0.3982 | NA | NA |
| JAK3 | tretinoin | 0.3985742 | 0.7268605 | 0.3986 | NA | NA |
| CD274 | tretinoin | 0.4075623 | 0.7268605 | 0.4076 | NA | NA |
| PML | tretinoin | 0.4081601 | 0.7268605 | 0.4082 | NA | NA |
| RAD21 | trametinib | 0.2729462 | 0.7270095 | 0.27295 | NA | NA |
| ERBB2 | trametinib | 0.2740267 | 0.7270095 | 0.27403 | NA | NA |
| NT5C2 | palbociclib | 0.1332752 | 0.7274606 | 0.1333 | NA | NA |
| ALK | temozolomide | 0.4005886 | 0.7314423 | 0.40059 | NA | NA |
| FGFR1 | temozolomide | 0.4020141 | 0.7314423 | 0.40201 | NA | NA |
| BRAF | imatinib | 0.3365852 | 0.7332278 | 0.337 | NA | NA |
| IKZF1 | imatinib | 0.3413302 | 0.7332278 | 0.341 | NA | NA |
| XPO1 | docetaxel | 0.3105293 | 0.7339784 | 0.31053 | NA | NA |
| SF1 | docetaxel | 0.3162400 | 0.7341286 | 0.31624 | NA | NA |
| FGFR3 | docetaxel | 0.3221893 | 0.7348178 | 0.32219 | NA | NA |
| PDCD1 | ruxolitinib | 0.2638283 | 0.7353513 | 0.2638 | NA | NA |
| IDH2 | docetaxel | 0.3288933 | 0.7371745 | 0.32889 | NA | NA |
| GNAQ | dabrafenib | 0.2310189 | 0.7373099 | 0.23102 | NA | NA |
| CXCR4 | dabrafenib | 0.2424069 | 0.7373099 | 0.24241 | NA | NA |
| G6PD | dabrafenib | 0.2443393 | 0.7373099 | 0.24434 | NA | NA |
| SH2B3 | dabrafenib | 0.2453136 | 0.7373099 | 0.24531 | NA | NA |
| ERBB2 | dabrafenib | 0.2521562 | 0.7373099 | 0.25216 | NA | NA |
| PML | dabrafenib | 0.2532744 | 0.7373099 | 0.25327 | NA | NA |
| CTCF | gefitinib | 0.0736147 | 0.7376340 | 0.0736 | NA | NA |
| ZRSR2 | gefitinib | 0.0752776 | 0.7376340 | 0.0753 | NA | NA |
| ALK | gefitinib | 0.0794375 | 0.7376340 | 0.0794 | NA | NA |
| AR | ruxolitinib | 0.2707866 | 0.7390218 | 0.2708 | NA | NA |
| RPL10 | afatinib | 0.0872294 | 0.7408454 | 0.0872 | NA | NA |
| CBL | afatinib | 0.0971709 | 0.7408454 | 0.0972 | NA | NA |
| TP53 | afatinib | 0.1112751 | 0.7408454 | 0.1113 | NA | NA |
| XPO1 | afatinib | 0.1226343 | 0.7408454 | 0.1226 | NA | NA |
| MGMT | afatinib | 0.1228036 | 0.7408454 | 0.1228 | NA | NA |
| NOTCH2 | afatinib | 0.1313985 | 0.7408454 | 0.1314 | NA | NA |
| GATA1 | afatinib | 0.1322836 | 0.7408454 | 0.1323 | NA | NA |
| PDGFRA | afatinib | 0.1332170 | 0.7408454 | 0.1332 | NA | NA |
| FGFR3 | afatinib | 0.1440811 | 0.7408454 | 0.1441 | NA | NA |
| MAP2K1 | afatinib | 0.1443384 | 0.7408454 | 0.1443 | NA | NA |
| EZH2 | afatinib | 0.1496126 | 0.7408454 | 0.1496 | NA | NA |
| TSC2 | afatinib | 0.1594651 | 0.7408454 | 0.1595 | NA | NA |
| IDH2 | afatinib | 0.1625545 | 0.7408454 | 0.1626 | NA | NA |
| FBXW7 | afatinib | 0.1685081 | 0.7408454 | 0.1685 | NA | NA |
| PAX5 | afatinib | 0.1796773 | 0.7408454 | 0.1797 | NA | NA |
| ZRSR2 | afatinib | 0.1797553 | 0.7408454 | 0.1798 | NA | NA |
| FGFR1 | afatinib | 0.1808783 | 0.7408454 | 0.1809 | NA | NA |
| MYD88 | afatinib | 0.1823685 | 0.7408454 | 0.1824 | NA | NA |
| KRAS | afatinib | 0.1838668 | 0.7408454 | 0.1839 | NA | NA |
| MET | afatinib | 0.1841947 | 0.7408454 | 0.1842 | NA | NA |
| ALK | afatinib | 0.1885392 | 0.7408454 | 0.1885 | NA | NA |
| RIT1 | afatinib | 0.1891551 | 0.7408454 | 0.1892 | NA | NA |
| BCORL1 | afatinib | 0.2049112 | 0.7408454 | 0.2049 | NA | NA |
| RAD21 | afatinib | 0.2088507 | 0.7408454 | 0.2089 | NA | NA |
| CTNNB1 | afatinib | 0.2104143 | 0.7408454 | 0.2104 | NA | NA |
| G6PD | afatinib | 0.2109900 | 0.7408454 | 0.2110 | NA | NA |
| PDGFB | afatinib | 0.2297013 | 0.7408454 | 0.2297 | NA | NA |
| MDM2 | afatinib | 0.2429813 | 0.7408454 | 0.2430 | NA | NA |
| BTK | afatinib | 0.2500025 | 0.7408454 | 0.2500 | NA | NA |
| BRCA2 | afatinib | 0.2553180 | 0.7408454 | 0.2553 | NA | NA |
| CTLA4 | afatinib | 0.2557520 | 0.7408454 | 0.2558 | NA | NA |
| SH2B3 | afatinib | 0.2597980 | 0.7408454 | 0.2598 | NA | NA |
| ERBB4 | afatinib | 0.2599147 | 0.7408454 | 0.2599 | NA | NA |
| SF3B1 | afatinib | 0.2607779 | 0.7408454 | 0.2608 | NA | NA |
| PTCH1 | afatinib | 0.2628105 | 0.7408454 | 0.2628 | NA | NA |
| DNMT3A | afatinib | 0.2639824 | 0.7408454 | 0.2640 | NA | NA |
| CDC73 | afatinib | 0.2743006 | 0.7408454 | 0.2743 | NA | NA |
| SRSF2 | afatinib | 0.2781061 | 0.7408454 | 0.2781 | NA | NA |
| PIGA | afatinib | 0.2792417 | 0.7408454 | 0.2792 | NA | NA |
| MAP2K1 | cabozantinib | 0.3789920 | 0.7410143 | 0.3790 | NA | NA |
| CDKN2A | alectinib | 0.2605683 | 0.7420533 | 0.2606 | NA | NA |
| ERBB2 | gefitinib | 0.0989296 | 0.7427156 | 0.0989 | NA | NA |
| RPL10 | gefitinib | 0.1035789 | 0.7427156 | 0.1036 | NA | NA |
| CXCR4 | gefitinib | 0.1064188 | 0.7427156 | 0.1064 | NA | NA |
| PDGFRA | gefitinib | 0.1077698 | 0.7427156 | 0.1078 | NA | NA |
| SRSF2 | gefitinib | 0.1142775 | 0.7427156 | 0.1143 | NA | NA |
| GATA1 | gefitinib | 0.1169619 | 0.7427156 | 0.1170 | NA | NA |
| NRAS | gefitinib | 0.1262378 | 0.7427156 | 0.1262 | NA | NA |
| MGMT | gefitinib | 0.1263998 | 0.7427156 | 0.1264 | NA | NA |
| PTCH1 | gefitinib | 0.1346354 | 0.7427156 | 0.1346 | NA | NA |
| CREBBP | gefitinib | 0.1371167 | 0.7427156 | 0.1371 | NA | NA |
| KIT | ruxolitinib | 0.2812051 | 0.7487302 | 0.2812 | NA | NA |
| CDK6 | ruxolitinib | 0.2857749 | 0.7487302 | 0.2858 | NA | NA |
| NRAS | dabrafenib | 0.2669909 | 0.7501833 | 0.26699 | NA | NA |
| DPYD | dabrafenib | 0.2691497 | 0.7501833 | 0.26915 | NA | NA |
| CSF3R | trametinib | 0.2947229 | 0.7517448 | 0.29472 | NA | NA |
| FLT3 | trametinib | 0.2977892 | 0.7517448 | 0.29779 | NA | NA |
| ASXL1 | trametinib | 0.3050617 | 0.7517448 | 0.30506 | NA | NA |
| BTK | trametinib | 0.3064806 | 0.7517448 | 0.30648 | NA | NA |
| BRCA2 | midostaurin | 0.0058907 | 0.7519282 | 0.0059 | ** | NA |
| PTEN | midostaurin | 0.0178005 | 0.7519282 | 0.0178 |
|
NA |
| CREBBP | midostaurin | 0.0242074 | 0.7519282 | 0.0242 |
|
NA |
| EGF | midostaurin | 0.0320598 | 0.7519282 | 0.0321 |
|
NA |
| GNAS | midostaurin | 0.0345520 | 0.7519282 | 0.0346 |
|
NA |
| UGT1A1 | midostaurin | 0.0385592 | 0.7519282 | 0.0386 |
|
NA |
| FGFR1 | midostaurin | 0.0551905 | 0.7519282 | 0.0552 | NA | NA |
| SETD2 | midostaurin | 0.0586843 | 0.7519282 | 0.0587 | NA | NA |
| BCORL1 | midostaurin | 0.0699458 | 0.7519282 | 0.0699 | NA | NA |
| PRPF8 | midostaurin | 0.0781692 | 0.7519282 | 0.0782 | NA | NA |
| PIK3CA | midostaurin | 0.0837587 | 0.7519282 | 0.0838 | NA | NA |
| CTNNB1 | midostaurin | 0.0843253 | 0.7519282 | 0.0843 | NA | NA |
| RPL10 | midostaurin | 0.0870012 | 0.7519282 | 0.0870 | NA | NA |
| PDGFRB | midostaurin | 0.0887296 | 0.7519282 | 0.0887 | NA | NA |
| SRSF2 | midostaurin | 0.0908838 | 0.7519282 | 0.0909 | NA | NA |
| WT1 | midostaurin | 0.0964995 | 0.7519282 | 0.0965 | NA | NA |
| BCOR | midostaurin | 0.1045093 | 0.7519282 | 0.1045 | NA | NA |
| PML | midostaurin | 0.1046555 | 0.7519282 | 0.1047 | NA | NA |
| ERBB3 | midostaurin | 0.1104412 | 0.7519282 | 0.1104 | NA | NA |
| ERBB2 | midostaurin | 0.1231748 | 0.7519282 | 0.1232 | NA | NA |
| PTCH1 | midostaurin | 0.1266216 | 0.7519282 | 0.1266 | NA | NA |
| ATM | midostaurin | 0.1408355 | 0.7519282 | 0.1408 | NA | NA |
| AKT1 | midostaurin | 0.1419954 | 0.7519282 | 0.1420 | NA | NA |
| AKT3 | midostaurin | 0.1590833 | 0.7519282 | 0.1591 | NA | NA |
| CALR | midostaurin | 0.1612397 | 0.7519282 | 0.1612 | NA | NA |
| BRCA1 | midostaurin | 0.1683042 | 0.7519282 | 0.1683 | NA | NA |
| VHL | midostaurin | 0.1715663 | 0.7519282 | 0.1716 | NA | NA |
| SMC3 | midostaurin | 0.1875982 | 0.7519282 | 0.1876 | NA | NA |
| TSC1 | midostaurin | 0.1925940 | 0.7519282 | 0.1926 | NA | NA |
| NPM1 | midostaurin | 0.1944832 | 0.7519282 | 0.1945 | NA | NA |
| FGFR3 | midostaurin | 0.1981794 | 0.7519282 | 0.1982 | NA | NA |
| CEBPA | midostaurin | 0.1997120 | 0.7519282 | 0.1997 | NA | NA |
| PRPF40B | midostaurin | 0.2032107 | 0.7519282 | 0.2032 | NA | NA |
| MAP2K2 | midostaurin | 0.2109847 | 0.7519282 | 0.2110 | NA | NA |
| MPL | midostaurin | 0.2151839 | 0.7519282 | 0.2152 | NA | NA |
| IKZF1 | midostaurin | 0.2196854 | 0.7519282 | 0.2197 | NA | NA |
| PTPN11 | midostaurin | 0.2220450 | 0.7519282 | 0.2220 | NA | NA |
| MDM2 | midostaurin | 0.2236312 | 0.7519282 | 0.2236 | NA | NA |
| GATA1 | midostaurin | 0.2317022 | 0.7519282 | 0.2317 | NA | NA |
| IL7R | midostaurin | 0.2368814 | 0.7519282 | 0.2369 | NA | NA |
| DNAJB1 | midostaurin | 0.2553242 | 0.7519282 | 0.2553 | NA | NA |
| CD274 | midostaurin | 0.2584055 | 0.7519282 | 0.2584 | NA | NA |
| CSF3R | midostaurin | 0.2617885 | 0.7519282 | 0.2618 | NA | NA |
| MGMT | midostaurin | 0.2670503 | 0.7519282 | 0.2671 | NA | NA |
| TET2 | midostaurin | 0.2773549 | 0.7519282 | 0.2774 | NA | NA |
| GNA11 | midostaurin | 0.2792650 | 0.7519282 | 0.2793 | NA | NA |
| JAK1 | midostaurin | 0.2818427 | 0.7519282 | 0.2818 | NA | NA |
| PDGFRA | midostaurin | 0.2883532 | 0.7519282 | 0.2884 | NA | NA |
| CDK6 | midostaurin | 0.2899976 | 0.7519282 | 0.2900 | NA | NA |
| PIGA | midostaurin | 0.2909512 | 0.7519282 | 0.2910 | NA | NA |
| KRAS | midostaurin | 0.2927354 | 0.7519282 | 0.2927 | NA | NA |
| XPO1 | ruxolitinib | 0.3027717 | 0.7528139 | 0.3028 | NA | NA |
| AKT1 | ruxolitinib | 0.3044779 | 0.7528139 | 0.3045 | NA | NA |
| TSC1 | ruxolitinib | 0.3045736 | 0.7528139 | 0.3046 | NA | NA |
| EGFR | alectinib | 0.2707820 | 0.7547328 | 0.2708 | NA | NA |
| MDM2 | alectinib | 0.2810211 | 0.7579011 | 0.2810 | NA | NA |
| CD79B | alectinib | 0.2908767 | 0.7579011 | 0.2909 | NA | NA |
| AKT1 | alectinib | 0.2956410 | 0.7579011 | 0.2956 | NA | NA |
| FGFR1 | alectinib | 0.3000040 | 0.7579011 | 0.3000 | NA | NA |
| JAK3 | alectinib | 0.3008462 | 0.7579011 | 0.3008 | NA | NA |
| CSF3R | dabrafenib | 0.2822100 | 0.7588163 | 0.28221 | NA | NA |
| CTNNB1 | dabrafenib | 0.2892579 | 0.7588163 | 0.28926 | NA | NA |
| CD274 | dabrafenib | 0.2936109 | 0.7588163 | 0.29361 | NA | NA |
| SETBP1 | dabrafenib | 0.2954170 | 0.7588163 | 0.29542 | NA | NA |
| NOTCH2 | rucaparib | 0.0108793 | 0.7594594 | 0.011 |
|
NA |
| EZH2 | rucaparib | 0.0182099 | 0.7594594 | 0.018 |
|
NA |
| ZRSR2 | rucaparib | 0.0409566 | 0.7594594 | 0.041 |
|
NA |
| MAP2K2 | rucaparib | 0.0415245 | 0.7594594 | 0.042 |
|
NA |
| TSC1 | rucaparib | 0.0503265 | 0.7594594 | 0.050 | NA | NA |
| TP53 | rucaparib | 0.0614824 | 0.7594594 | 0.061 | NA | NA |
| GNAQ | rucaparib | 0.0616841 | 0.7594594 | 0.062 | NA | NA |
| GNB1 | rucaparib | 0.0624029 | 0.7594594 | 0.062 | NA | NA |
| SSX1 | rucaparib | 0.0860961 | 0.7594594 | 0.086 | NA | NA |
| PTPN11 | rucaparib | 0.0881492 | 0.7594594 | 0.088 | NA | NA |
| VHL | rucaparib | 0.0888741 | 0.7594594 | 0.089 | NA | NA |
| PTEN | rucaparib | 0.0938970 | 0.7594594 | 0.094 | NA | NA |
| DNMT3A | rucaparib | 0.0975186 | 0.7594594 | 0.098 | NA | NA |
| MDM2 | rucaparib | 0.1105299 | 0.7594594 | 0.111 | NA | NA |
| PIK3CA | rucaparib | 0.1220643 | 0.7594594 | 0.122 | NA | NA |
| EED | rucaparib | 0.1231156 | 0.7594594 | 0.123 | NA | NA |
| NOTCH1 | rucaparib | 0.1306394 | 0.7594594 | 0.131 | NA | NA |
| JAK3 | rucaparib | 0.1342473 | 0.7594594 | 0.134 | NA | NA |
| CDKN2A | rucaparib | 0.1382694 | 0.7594594 | 0.138 | NA | NA |
| BRAF | rucaparib | 0.1413053 | 0.7594594 | 0.141 | NA | NA |
| RIT1 | rucaparib | 0.1426020 | 0.7594594 | 0.143 | NA | NA |
| PRPF8 | rucaparib | 0.1466626 | 0.7594594 | 0.147 | NA | NA |
| IL7R | rucaparib | 0.1489089 | 0.7594594 | 0.149 | NA | NA |
| IDH2 | rucaparib | 0.1502920 | 0.7594594 | 0.150 | NA | NA |
| AKT2 | rucaparib | 0.1688628 | 0.7594594 | 0.169 | NA | NA |
| AR | rucaparib | 0.1732681 | 0.7594594 | 0.173 | NA | NA |
| RPL10 | rucaparib | 0.1749059 | 0.7594594 | 0.175 | NA | NA |
| CBLB | rucaparib | 0.1753511 | 0.7594594 | 0.175 | NA | NA |
| CD274 | rucaparib | 0.1767650 | 0.7594594 | 0.177 | NA | NA |
| SMC3 | rucaparib | 0.1824393 | 0.7594594 | 0.182 | NA | NA |
| GNA11 | rucaparib | 0.1867700 | 0.7594594 | 0.187 | NA | NA |
| CDC73 | rucaparib | 0.1947424 | 0.7594594 | 0.195 | NA | NA |
| CALR | rucaparib | 0.1970713 | 0.7594594 | 0.197 | NA | NA |
| FLT3 | rucaparib | 0.1971116 | 0.7594594 | 0.197 | NA | NA |
| MAP2K2 | palbociclib | 0.1451389 | 0.7601489 | 0.1451 | NA | NA |
| HRAS | palbociclib | 0.1615122 | 0.7601489 | 0.1615 | NA | NA |
| CDK4 | palbociclib | 0.1723047 | 0.7601489 | 0.1723 | NA | NA |
| MDM2 | palbociclib | 0.1794132 | 0.7601489 | 0.1794 | NA | NA |
| GATA1 | palbociclib | 0.1856767 | 0.7601489 | 0.1857 | NA | NA |
| SSX1 | palbociclib | 0.1877964 | 0.7601489 | 0.1878 | NA | NA |
| CRLF2 | palbociclib | 0.1904735 | 0.7601489 | 0.1905 | NA | NA |
| UGT1A1 | palbociclib | 0.2007621 | 0.7601489 | 0.2008 | NA | NA |
| PML | palbociclib | 0.2018104 | 0.7601489 | 0.2018 | NA | NA |
| ERBB4 | palbociclib | 0.2071288 | 0.7601489 | 0.2071 | NA | NA |
| ABL1 | palbociclib | 0.2122468 | 0.7601489 | 0.2122 | NA | NA |
| PDCD1 | palbociclib | 0.2138133 | 0.7601489 | 0.2138 | NA | NA |
| ESR1 | palbociclib | 0.2146985 | 0.7601489 | 0.2147 | NA | NA |
| MAP2K2 | trametinib | 0.3188070 | 0.7603269 | 0.31881 | NA | NA |
| EGF | trametinib | 0.3216768 | 0.7603269 | 0.32168 | NA | NA |
| PRPF8 | tretinoin | 0.4328990 | 0.7604982 | 0.4329 | NA | NA |
| PTPN11 | docetaxel | 0.3505582 | 0.7609892 | 0.35056 | NA | NA |
| CDK4 | docetaxel | 0.3512258 | 0.7609892 | 0.35123 | NA | NA |
| KMT2A | imatinib | 0.3610200 | 0.7614240 | 0.361 | NA | NA |
| CEBPA | palbociclib | 0.2217988 | 0.7616445 | 0.2218 | NA | NA |
| DDIT3 | palbociclib | 0.2290040 | 0.7616445 | 0.2290 | NA | NA |
| MGMT | palbociclib | 0.2389195 | 0.7616445 | 0.2389 | NA | NA |
| RIT1 | palbociclib | 0.2411715 | 0.7616445 | 0.2412 | NA | NA |
| RAD21 | palbociclib | 0.2494293 | 0.7616445 | 0.2494 | NA | NA |
| NRAS | palbociclib | 0.2500055 | 0.7616445 | 0.2500 | NA | NA |
| U2AF1 | rucaparib | 0.2035438 | 0.7618353 | 0.204 | NA | NA |
| PTCH1 | docetaxel | 0.3578141 | 0.7625547 | 0.35781 | NA | NA |
| SMC1A | cabozantinib | 0.3971299 | 0.7626517 | 0.3971 | NA | NA |
| BCORL1 | cabozantinib | 0.4040076 | 0.7626517 | 0.4040 | NA | NA |
| ASXL1 | cabozantinib | 0.4107168 | 0.7626517 | 0.4107 | NA | NA |
| CDC73 | cabozantinib | 0.4149638 | 0.7626517 | 0.4150 | NA | NA |
| AKT3 | cabozantinib | 0.4216866 | 0.7626517 | 0.4217 | NA | NA |
| PIGA | cabozantinib | 0.4249891 | 0.7626517 | 0.4250 | NA | NA |
| KIT | nilotinib | 0.0509383 | 0.7627601 | 0.0509 | NA | NA |
| STAT3 | nilotinib | 0.0689287 | 0.7627601 | 0.0689 | NA | NA |
| TSC1 | nilotinib | 0.0779898 | 0.7627601 | 0.0780 | NA | NA |
| SF3B1 | nilotinib | 0.0801719 | 0.7627601 | 0.0802 | NA | NA |
| AKT1 | nilotinib | 0.0856959 | 0.7627601 | 0.0857 | NA | NA |
| DDIT3 | nilotinib | 0.0871195 | 0.7627601 | 0.0871 | NA | NA |
| RPL10 | nilotinib | 0.0874302 | 0.7627601 | 0.0874 | NA | NA |
| DNAJB1 | nilotinib | 0.1060679 | 0.7627601 | 0.1061 | NA | NA |
| TET2 | nilotinib | 0.1073900 | 0.7627601 | 0.1074 | NA | NA |
| XPO1 | nilotinib | 0.1080468 | 0.7627601 | 0.1080 | NA | NA |
| CTLA4 | nilotinib | 0.1201225 | 0.7627601 | 0.1201 | NA | NA |
| TSC2 | nilotinib | 0.1328358 | 0.7627601 | 0.1328 | NA | NA |
| JAK3 | nilotinib | 0.1339154 | 0.7627601 | 0.1339 | NA | NA |
| PDGFRA | nilotinib | 0.1346957 | 0.7627601 | 0.1347 | NA | NA |
| MPL | nilotinib | 0.1396520 | 0.7627601 | 0.1397 | NA | NA |
| CTNNB1 | nilotinib | 0.1455938 | 0.7627601 | 0.1456 | NA | NA |
| CALR | nilotinib | 0.1528002 | 0.7627601 | 0.1528 | NA | NA |
| FLT3 | nilotinib | 0.1535908 | 0.7627601 | 0.1536 | NA | NA |
| EZH2 | nilotinib | 0.1537478 | 0.7627601 | 0.1537 | NA | NA |
| ESR1 | nilotinib | 0.1779167 | 0.7627601 | 0.1779 | NA | NA |
| GNAS | nilotinib | 0.1788003 | 0.7627601 | 0.1788 | NA | NA |
| DNMT3A | nilotinib | 0.1870610 | 0.7627601 | 0.1871 | NA | NA |
| PDCD1 | nilotinib | 0.1981914 | 0.7627601 | 0.1982 | NA | NA |
| SETBP1 | nilotinib | 0.1987831 | 0.7627601 | 0.1988 | NA | NA |
| GNB1 | nilotinib | 0.2017232 | 0.7627601 | 0.2017 | NA | NA |
| STAG2 | nilotinib | 0.2125771 | 0.7627601 | 0.2126 | NA | NA |
| IKZF1 | nilotinib | 0.2133452 | 0.7627601 | 0.2133 | NA | NA |
| NT5C2 | nilotinib | 0.2223316 | 0.7627601 | 0.2223 | NA | NA |
| FANCL | nilotinib | 0.2322908 | 0.7627601 | 0.2323 | NA | NA |
| HRAS | nilotinib | 0.2403406 | 0.7627601 | 0.2403 | NA | NA |
| U2AF1 | nilotinib | 0.2644922 | 0.7627601 | 0.2645 | NA | NA |
| TPMT | nilotinib | 0.2737875 | 0.7627601 | 0.2738 | NA | NA |
| PDGFRB | nilotinib | 0.2738696 | 0.7627601 | 0.2739 | NA | NA |
| PDGFB | nilotinib | 0.2752114 | 0.7627601 | 0.2752 | NA | NA |
| SRSF2 | nilotinib | 0.2812050 | 0.7627601 | 0.2812 | NA | NA |
| RIT1 | nilotinib | 0.2868250 | 0.7627601 | 0.2868 | NA | NA |
| PRPF40B | nilotinib | 0.3059911 | 0.7627601 | 0.3060 | NA | NA |
| PTCH1 | nilotinib | 0.3093982 | 0.7627601 | 0.3094 | NA | NA |
| CXCR4 | nilotinib | 0.3164078 | 0.7627601 | 0.3164 | NA | NA |
| SMO | nilotinib | 0.3168786 | 0.7627601 | 0.3169 | NA | NA |
| ZRSR2 | nilotinib | 0.3197215 | 0.7627601 | 0.3197 | NA | NA |
| NPM1 | nilotinib | 0.3197255 | 0.7627601 | 0.3197 | NA | NA |
| PIK3CA | nilotinib | 0.3221612 | 0.7627601 | 0.3222 | NA | NA |
| ERBB2 | nilotinib | 0.3322155 | 0.7627601 | 0.3322 | NA | NA |
| ROS1 | nilotinib | 0.3339538 | 0.7627601 | 0.3340 | NA | NA |
| BCORL1 | nilotinib | 0.3383996 | 0.7627601 | 0.3384 | NA | NA |
| SH2B3 | nilotinib | 0.3391378 | 0.7627601 | 0.3391 | NA | NA |
| WHSC1 | nilotinib | 0.3455546 | 0.7627601 | 0.3456 | NA | NA |
| NCOA2 | nilotinib | 0.3469922 | 0.7627601 | 0.3470 | NA | NA |
| EGF | nilotinib | 0.3526555 | 0.7627601 | 0.3527 | NA | NA |
| SETD2 | nilotinib | 0.3549033 | 0.7627601 | 0.3549 | NA | NA |
| CBL | nilotinib | 0.3567703 | 0.7627601 | 0.3568 | NA | NA |
| BRAF | nilotinib | 0.3579029 | 0.7627601 | 0.3579 | NA | NA |
| TP53 | nilotinib | 0.3614059 | 0.7627601 | 0.3614 | NA | NA |
| ATM | nilotinib | 0.3703913 | 0.7627601 | 0.3704 | NA | NA |
| G6PD | nilotinib | 0.3817505 | 0.7627601 | 0.3818 | NA | NA |
| CTCF | nilotinib | 0.3876743 | 0.7627601 | 0.3877 | NA | NA |
| GATA1 | nilotinib | 0.3965339 | 0.7627601 | 0.3965 | NA | NA |
| CYP19A1 | nilotinib | 0.3966596 | 0.7627601 | 0.3967 | NA | NA |
| SF1 | nilotinib | 0.3986195 | 0.7627601 | 0.3986 | NA | NA |
| VHL | nilotinib | 0.4061768 | 0.7627601 | 0.4062 | NA | NA |
| RUNX1 | nilotinib | 0.4072745 | 0.7627601 | 0.4073 | NA | NA |
| GNA11 | nilotinib | 0.4200233 | 0.7627601 | 0.4200 | NA | NA |
| BRCA1 | nilotinib | 0.4230452 | 0.7627601 | 0.4230 | NA | NA |
| KMT2A | nilotinib | 0.4270492 | 0.7627601 | 0.4270 | NA | NA |
| PTPN11 | nilotinib | 0.4343504 | 0.7627601 | 0.4344 | NA | NA |
| NRAS | nilotinib | 0.4375929 | 0.7627601 | 0.4376 | NA | NA |
| MYD88 | nilotinib | 0.4453090 | 0.7627601 | 0.4453 | NA | NA |
| CD274 | nilotinib | 0.4563967 | 0.7627601 | 0.4564 | NA | NA |
| JAK2 | nilotinib | 0.4609294 | 0.7627601 | 0.4609 | NA | NA |
| MET | nilotinib | 0.4620552 | 0.7627601 | 0.4621 | NA | NA |
| EML4 | nilotinib | 0.4635234 | 0.7627601 | 0.4635 | NA | NA |
| SF3B1 | midostaurin | 0.3064956 | 0.7635258 | 0.3065 | NA | NA |
| FBXW7 | midostaurin | 0.3089074 | 0.7635258 | 0.3089 | NA | NA |
| CDK6 | temozolomide | 0.4260949 | 0.7646361 | 0.42609 | NA | NA |
| GNAS | alectinib | 0.3097168 | 0.7655264 | 0.3097 | NA | NA |
| PDGFB | temozolomide | 0.4372281 | 0.7683307 | 0.43723 | NA | NA |
| FLT3 | temozolomide | 0.4398840 | 0.7683307 | 0.43988 | NA | NA |
| AKT2 | erlotinib | 0.2541238 | 0.7690587 | 0.2541 | NA | NA |
| SSX1 | tretinoin | 0.4437195 | 0.7691137 | 0.4437 | NA | NA |
| G6PD | tretinoin | 0.4531080 | 0.7692065 | 0.4531 | NA | NA |
| VHL | tretinoin | 0.4556069 | 0.7692065 | 0.4556 | NA | NA |
| SF1 | alectinib | 0.3234420 | 0.7717293 | 0.3234 | NA | NA |
| SSX1 | alectinib | 0.3293082 | 0.7717293 | 0.3293 | NA | NA |
| GATA1 | alectinib | 0.3310119 | 0.7717293 | 0.3310 | NA | NA |
| KMT2A | alectinib | 0.3437441 | 0.7717293 | 0.3437 | NA | NA |
| BTK | alectinib | 0.3449044 | 0.7717293 | 0.3449 | NA | NA |
| BRCA1 | alectinib | 0.3475727 | 0.7717293 | 0.3476 | NA | NA |
| ZRSR2 | temozolomide | 0.4480301 | 0.7719287 | 0.44803 | NA | NA |
| MYD88 | temozolomide | 0.4590388 | 0.7719287 | 0.45904 | NA | NA |
| KIT | temozolomide | 0.4596217 | 0.7719287 | 0.45962 | NA | NA |
| TSC2 | palbociclib | 0.2593090 | 0.7720335 | 0.2593 | NA | NA |
| MDM2 | dabrafenib | 0.3064629 | 0.7720508 | 0.30646 | NA | NA |
| SMC1A | midostaurin | 0.3236533 | 0.7723736 | 0.3237 | NA | NA |
| FGFR2 | midostaurin | 0.3242790 | 0.7723736 | 0.3243 | NA | NA |
| PTPN11 | ponatinib | 0.1536929 | 0.7743760 | 0.154 | NA | NA |
| EGFR | midostaurin | 0.3312793 | 0.7749570 | 0.3313 | NA | NA |
| WHSC1 | imatinib | 0.3820492 | 0.7780805 | 0.382 | NA | NA |
| RET | imatinib | 0.3884249 | 0.7780805 | 0.388 | NA | NA |
| SMO | imatinib | 0.3890402 | 0.7780805 | 0.389 | NA | NA |
| NOTCH2 | cabozantinib | 0.4395724 | 0.7781619 | 0.4396 | NA | NA |
| CYP19A1 | alectinib | 0.3564980 | 0.7783540 | 0.3565 | NA | NA |
| BCORL1 | docetaxel | 0.3721966 | 0.7804122 | 0.37220 | NA | NA |
| BCOR | nilotinib | 0.4843638 | 0.7821006 | 0.4844 | NA | NA |
| UGT1A1 | nilotinib | 0.4918297 | 0.7821006 | 0.4918 | NA | NA |
| AR | nilotinib | 0.4970145 | 0.7821006 | 0.4970 | NA | NA |
| EGFR | nilotinib | 0.4993412 | 0.7821006 | 0.4993 | NA | NA |
| ATM | imatinib | 0.4026488 | 0.7843764 | 0.403 | NA | NA |
| TP53 | imatinib | 0.4057119 | 0.7843764 | 0.406 | NA | NA |
| GNA11 | cabozantinib | 0.4525437 | 0.7855968 | 0.4525 | NA | NA |
| FGFR3 | cabozantinib | 0.4557661 | 0.7855968 | 0.4558 | NA | NA |
| CTCF | alectinib | 0.3665010 | 0.7870759 | 0.3665 | NA | NA |
| PAX5 | docetaxel | 0.3815151 | 0.7872535 | 0.38152 | NA | NA |
| FANCL | palbociclib | 0.2705871 | 0.7877090 | 0.2706 | NA | NA |
| CDK6 | nilotinib | 0.5134963 | 0.7911873 | 0.5135 | NA | NA |
| IL7R | nilotinib | 0.5173148 | 0.7911873 | 0.5173 | NA | NA |
| PTEN | palbociclib | 0.2856346 | 0.7915761 | 0.2856 | NA | NA |
| NCOA2 | palbociclib | 0.2859635 | 0.7915761 | 0.2860 | NA | NA |
| MET | palbociclib | 0.2900431 | 0.7915761 | 0.2900 | NA | NA |
| ERBB3 | nilotinib | 0.5371710 | 0.7921853 | 0.5372 | NA | NA |
| MAP2K2 | nilotinib | 0.5386936 | 0.7921853 | 0.5387 | NA | NA |
| FGFR2 | nilotinib | 0.5398280 | 0.7921853 | 0.5398 | NA | NA |
| PIGA | nilotinib | 0.5423423 | 0.7921853 | 0.5423 | NA | NA |
| MYD88 | tretinoin | 0.4774785 | 0.7957975 | 0.4775 | NA | NA |
| MAP2K2 | ruxolitinib | 0.3295676 | 0.7995065 | 0.3296 | NA | NA |
| AR | trametinib | 0.3489364 | 0.8000202 | 0.34894 | NA | NA |
| CEBPA | trametinib | 0.3520319 | 0.8000202 | 0.35203 | NA | NA |
| ERBB4 | trametinib | 0.3576230 | 0.8000202 | 0.35762 | NA | NA |
| RUNX1 | trametinib | 0.3720382 | 0.8000202 | 0.37204 | NA | NA |
| PRPF40B | trametinib | 0.3750237 | 0.8000202 | 0.37502 | NA | NA |
| PIGA | trametinib | 0.3753941 | 0.8000202 | 0.37539 | NA | NA |
| PTCH1 | alectinib | 0.3832319 | 0.8020837 | 0.3832 | NA | NA |
| PAX8 | alectinib | 0.3871065 | 0.8020837 | 0.3871 | NA | NA |
| TSC1 | alectinib | 0.3956481 | 0.8020837 | 0.3956 | NA | NA |
| AKT2 | alectinib | 0.4024812 | 0.8020837 | 0.4025 | NA | NA |
| ERBB4 | alectinib | 0.4041032 | 0.8020837 | 0.4041 | NA | NA |
| SMC3 | ruxolitinib | 0.3368205 | 0.8022453 | 0.3368 | NA | NA |
| FLT3 | crizotinib | 0.0371049 | 0.8032944 | 0.0371 |
|
NA |
| TSC1 | crizotinib | 0.0396633 | 0.8032944 | 0.0397 |
|
NA |
| BRCA2 | crizotinib | 0.0408902 | 0.8032944 | 0.0409 |
|
NA |
| DNMT3A | crizotinib | 0.0577322 | 0.8032944 | 0.0577 | NA | NA |
| PML | crizotinib | 0.0605225 | 0.8032944 | 0.0605 | NA | NA |
| EZH2 | crizotinib | 0.0741267 | 0.8032944 | 0.0741 | NA | NA |
| DPYD | crizotinib | 0.0771266 | 0.8032944 | 0.0771 | NA | NA |
| ERBB2 | crizotinib | 0.0782120 | 0.8032944 | 0.0782 | NA | NA |
| RPL10 | crizotinib | 0.0879509 | 0.8032944 | 0.0880 | NA | NA |
| FLCN | crizotinib | 0.0928500 | 0.8032944 | 0.0929 | NA | NA |
| GNB1 | crizotinib | 0.0953243 | 0.8032944 | 0.0953 | NA | NA |
| SETBP1 | crizotinib | 0.1040172 | 0.8032944 | 0.1040 | NA | NA |
| XPO1 | crizotinib | 0.1179406 | 0.8032944 | 0.1179 | NA | NA |
| GATA3 | crizotinib | 0.1184833 | 0.8032944 | 0.1185 | NA | NA |
| MDM2 | crizotinib | 0.1214898 | 0.8032944 | 0.1215 | NA | NA |
| CDK6 | crizotinib | 0.1242377 | 0.8032944 | 0.1242 | NA | NA |
| MET | crizotinib | 0.1305419 | 0.8032944 | 0.1305 | NA | NA |
| ATM | crizotinib | 0.1315741 | 0.8032944 | 0.1316 | NA | NA |
| IKZF1 | trametinib | 0.3988024 | 0.8035274 | 0.39880 | NA | NA |
| DDIT3 | trametinib | 0.3990678 | 0.8035274 | 0.39907 | NA | NA |
| CTNNB1 | trametinib | 0.4064703 | 0.8035274 | 0.40647 | NA | NA |
| IDH2 | trametinib | 0.4108540 | 0.8035274 | 0.41085 | NA | NA |
| BRCA1 | trametinib | 0.4159320 | 0.8035274 | 0.41593 | NA | NA |
| DNMT3A | trametinib | 0.4166812 | 0.8035274 | 0.41668 | NA | NA |
| MDM2 | trametinib | 0.4203066 | 0.8035274 | 0.42031 | NA | NA |
| CTCF | rucaparib | 0.2351418 | 0.8068481 | 0.235 | NA | NA |
| RAD21 | rucaparib | 0.2491994 | 0.8068481 | 0.249 | NA | NA |
| EML4 | rucaparib | 0.2555029 | 0.8068481 | 0.256 | NA | NA |
| RUNX1 | rucaparib | 0.2593719 | 0.8068481 | 0.259 | NA | NA |
| BCOR | rucaparib | 0.2627595 | 0.8068481 | 0.263 | NA | NA |
| PIGA | rucaparib | 0.2683194 | 0.8068481 | 0.268 | NA | NA |
| NCOA2 | rucaparib | 0.2744830 | 0.8068481 | 0.274 | NA | NA |
| JAK2 | rucaparib | 0.2799799 | 0.8068481 | 0.280 | NA | NA |
| CDK6 | rucaparib | 0.2907652 | 0.8068481 | 0.291 | NA | NA |
| CBL | rucaparib | 0.2974374 | 0.8068481 | 0.297 | NA | NA |
| SF3B1 | rucaparib | 0.3037310 | 0.8068481 | 0.304 | NA | NA |
| MGMT | rucaparib | 0.3112521 | 0.8068481 | 0.311 | NA | NA |
| BRCA2 | rucaparib | 0.3140675 | 0.8068481 | 0.314 | NA | NA |
| ESR1 | rucaparib | 0.3155348 | 0.8068481 | 0.316 | NA | NA |
| KIT | rucaparib | 0.3176892 | 0.8068481 | 0.318 | NA | NA |
| ROS1 | rucaparib | 0.3210092 | 0.8068481 | 0.321 | NA | NA |
| IDH1 | rucaparib | 0.3365827 | 0.8068481 | 0.337 | NA | NA |
| GNAS | rucaparib | 0.3392393 | 0.8068481 | 0.339 | NA | NA |
| PDGFRB | rucaparib | 0.3399009 | 0.8068481 | 0.340 | NA | NA |
| MYD88 | rucaparib | 0.3422485 | 0.8068481 | 0.342 | NA | NA |
| DPYD | rucaparib | 0.3449122 | 0.8068481 | 0.345 | NA | NA |
| GATA2 | tretinoin | 0.4920281 | 0.8074716 | 0.4920 | NA | NA |
| RET | tretinoin | 0.4969056 | 0.8074716 | 0.4969 | NA | NA |
| PRPF8 | imatinib | 0.4337483 | 0.8076933 | 0.434 | NA | NA |
| DNMT3A | imatinib | 0.4384088 | 0.8076933 | 0.438 | NA | NA |
| IDH1 | imatinib | 0.4567885 | 0.8076933 | 0.457 | NA | NA |
| MYCN | imatinib | 0.4567885 | 0.8076933 | 0.457 | NA | NA |
| PML | imatinib | 0.4608455 | 0.8076933 | 0.461 | NA | NA |
| ABL1 | imatinib | 0.4679914 | 0.8076933 | 0.468 | NA | NA |
| PDGFRB | imatinib | 0.4699331 | 0.8076933 | 0.470 | NA | NA |
| CDKN2A | imatinib | 0.4734754 | 0.8076933 | 0.473 | NA | NA |
| DPYD | afatinib | 0.3107947 | 0.8080661 | 0.3108 | NA | NA |
| BRAF | bosutinib monohydrate | 0.0181741 | 0.8090479 | 0.0182 |
|
NA |
| KIT | bosutinib monohydrate | 0.0186703 | 0.8090479 | 0.0187 |
|
NA |
| NT5C2 | temozolomide | 0.5024237 | 0.8096138 | 0.50242 | NA | NA |
| MYCN | temozolomide | 0.5105673 | 0.8096138 | 0.51057 | NA | NA |
| EGF | temozolomide | 0.5143110 | 0.8096138 | 0.51431 | NA | NA |
| PDGFRB | temozolomide | 0.5143244 | 0.8096138 | 0.51432 | NA | NA |
| PTPN11 | temozolomide | 0.5198840 | 0.8096138 | 0.51988 | NA | NA |
| CXCR4 | temozolomide | 0.5324701 | 0.8096138 | 0.53247 | NA | NA |
| BRCA2 | temozolomide | 0.5416844 | 0.8096138 | 0.54168 | NA | NA |
| WT1 | temozolomide | 0.5429937 | 0.8096138 | 0.54299 | NA | NA |
| JAK3 | temozolomide | 0.5436890 | 0.8096138 | 0.54369 | NA | NA |
| SF1 | temozolomide | 0.5448516 | 0.8096138 | 0.54485 | NA | NA |
| UGT1A1 | temozolomide | 0.5500430 | 0.8096138 | 0.55004 | NA | NA |
| CBLB | cabozantinib | 0.4931138 | 0.8101575 | 0.4931 | NA | NA |
| MYD88 | cabozantinib | 0.4985291 | 0.8101575 | 0.4985 | NA | NA |
| RET | cabozantinib | 0.4991041 | 0.8101575 | 0.4991 | NA | NA |
| FANCL | cabozantinib | 0.5034590 | 0.8101575 | 0.5035 | NA | NA |
| CEBPA | cabozantinib | 0.5051263 | 0.8101575 | 0.5051 | NA | NA |
| DDIT3 | cabozantinib | 0.5071215 | 0.8101575 | 0.5071 | NA | NA |
| CBL | crizotinib | 0.1406039 | 0.8112139 | 0.1406 | NA | NA |
| CDK4 | crizotinib | 0.1634861 | 0.8112139 | 0.1635 | NA | NA |
| GATA1 | crizotinib | 0.1678222 | 0.8112139 | 0.1678 | NA | NA |
| TSC2 | crizotinib | 0.1757036 | 0.8112139 | 0.1757 | NA | NA |
| VHL | crizotinib | 0.1771829 | 0.8112139 | 0.1772 | NA | NA |
| RAD21 | crizotinib | 0.1897781 | 0.8112139 | 0.1898 | NA | NA |
| ERBB4 | crizotinib | 0.1962570 | 0.8112139 | 0.1963 | NA | NA |
| CTCF | crizotinib | 0.1973464 | 0.8112139 | 0.1973 | NA | NA |
| PAX5 | crizotinib | 0.2046329 | 0.8112139 | 0.2046 | NA | NA |
| PDCD1 | crizotinib | 0.2092666 | 0.8112139 | 0.2093 | NA | NA |
| EGFR | crizotinib | 0.2113667 | 0.8112139 | 0.2114 | NA | NA |
| MAP2K1 | crizotinib | 0.2167899 | 0.8112139 | 0.2168 | NA | NA |
| MGMT | dabrafenib | 0.3282216 | 0.8112646 | 0.32822 | NA | NA |
| AKT2 | docetaxel | 0.4005242 | 0.8120650 | 0.40052 | NA | NA |
| PDGFB | docetaxel | 0.4060325 | 0.8120650 | 0.40603 | NA | NA |
| IKZF1 | docetaxel | 0.4191295 | 0.8133959 | 0.41913 | NA | NA |
| FBXW7 | docetaxel | 0.4241498 | 0.8133959 | 0.42415 | NA | NA |
| ESR1 | docetaxel | 0.4254686 | 0.8133959 | 0.42547 | NA | NA |
| CTCF | tretinoin | 0.5098762 | 0.8149907 | 0.5099 | NA | NA |
| PIK3CA | tretinoin | 0.5140711 | 0.8149907 | 0.5141 | NA | NA |
| PHF6 | imatinib | 0.4884193 | 0.8160981 | 0.488 | NA | NA |
| PDCD1 | imatinib | 0.4965076 | 0.8160981 | 0.497 | NA | NA |
| G6PD | imatinib | 0.5046668 | 0.8160981 | 0.505 | NA | NA |
| TET2 | imatinib | 0.5098787 | 0.8160981 | 0.510 | NA | NA |
| DPYD | imatinib | 0.5204070 | 0.8160981 | 0.520 | NA | NA |
| EGFR | imatinib | 0.5206143 | 0.8160981 | 0.521 | NA | NA |
| GATA1 | rucaparib | 0.3564121 | 0.8168175 | 0.356 | NA | NA |
| MPL | rucaparib | 0.3616444 | 0.8168175 | 0.362 | NA | NA |
| RUNX1 | dasatinib | 0.0499298 | 0.8178090 | 0.050 |
|
NA |
| CTNNB1 | dasatinib | 0.0566920 | 0.8178090 | 0.057 | NA | NA |
| PDGFRB | dasatinib | 0.0763115 | 0.8178090 | 0.076 | NA | NA |
| CALR | dasatinib | 0.0794829 | 0.8178090 | 0.079 | NA | NA |
| GNAS | dasatinib | 0.0858809 | 0.8178090 | 0.086 | NA | NA |
| RPL10 | dasatinib | 0.0880978 | 0.8178090 | 0.088 | NA | NA |
| AR | dasatinib | 0.0930278 | 0.8178090 | 0.093 | NA | NA |
| BRCA2 | dasatinib | 0.0931223 | 0.8178090 | 0.093 | NA | NA |
| NPM1 | dasatinib | 0.0957018 | 0.8178090 | 0.096 | NA | NA |
| GNB1 | dasatinib | 0.1021196 | 0.8178090 | 0.102 | NA | NA |
| SMC3 | dasatinib | 0.1047138 | 0.8178090 | 0.105 | NA | NA |
| AKT3 | dasatinib | 0.1068213 | 0.8178090 | 0.107 | NA | NA |
| CREBBP | dasatinib | 0.1144672 | 0.8178090 | 0.114 | NA | NA |
| CBLB | dasatinib | 0.1279141 | 0.8178090 | 0.128 | NA | NA |
| RIT1 | dasatinib | 0.1353958 | 0.8178090 | 0.135 | NA | NA |
| SMC1A | dasatinib | 0.1356364 | 0.8178090 | 0.136 | NA | NA |
| WHSC1 | dasatinib | 0.1428838 | 0.8178090 | 0.143 | NA | NA |
| CBL | dasatinib | 0.1464269 | 0.8178090 | 0.146 | NA | NA |
| XPO1 | dasatinib | 0.1535899 | 0.8178090 | 0.154 | NA | NA |
| IKZF1 | dasatinib | 0.1560706 | 0.8178090 | 0.156 | NA | NA |
| DNAJB1 | dasatinib | 0.1772222 | 0.8178090 | 0.177 | NA | NA |
| WT1 | dasatinib | 0.1833368 | 0.8178090 | 0.183 | NA | NA |
| FLT3 | dasatinib | 0.2059686 | 0.8178090 | 0.206 | NA | NA |
| SMO | dasatinib | 0.2145199 | 0.8178090 | 0.215 | NA | NA |
| JAK3 | dasatinib | 0.2151836 | 0.8178090 | 0.215 | NA | NA |
| NOTCH2 | dasatinib | 0.2206354 | 0.8178090 | 0.221 | NA | NA |
| DNMT3A | dasatinib | 0.2260896 | 0.8178090 | 0.226 | NA | NA |
| FBXW7 | dasatinib | 0.2361556 | 0.8178090 | 0.236 | NA | NA |
| NT5C2 | dasatinib | 0.2417207 | 0.8178090 | 0.242 | NA | NA |
| ASXL1 | dasatinib | 0.2501299 | 0.8178090 | 0.250 | NA | NA |
| EGFR | dasatinib | 0.2539632 | 0.8178090 | 0.254 | NA | NA |
| STAT3 | dasatinib | 0.2617061 | 0.8178090 | 0.262 | NA | NA |
| GATA2 | dasatinib | 0.2620633 | 0.8178090 | 0.262 | NA | NA |
| NOTCH1 | dasatinib | 0.2625738 | 0.8178090 | 0.263 | NA | NA |
| PHF6 | dasatinib | 0.2853231 | 0.8178090 | 0.285 | NA | NA |
| FGFR3 | dasatinib | 0.2900699 | 0.8178090 | 0.290 | NA | NA |
| FANCL | dasatinib | 0.2913498 | 0.8178090 | 0.291 | NA | NA |
| ERBB4 | dasatinib | 0.3011735 | 0.8178090 | 0.301 | NA | NA |
| ERBB2 | dasatinib | 0.3121664 | 0.8178090 | 0.312 | NA | NA |
| VHL | dasatinib | 0.3136021 | 0.8178090 | 0.314 | NA | NA |
| CD79B | dasatinib | 0.3359203 | 0.8178090 | 0.336 | NA | NA |
| GNAQ | dasatinib | 0.3359203 | 0.8178090 | 0.336 | NA | NA |
| PDCD1 | dasatinib | 0.3359203 | 0.8178090 | 0.336 | NA | NA |
| DPYD | dasatinib | 0.3450704 | 0.8178090 | 0.345 | NA | NA |
| EGF | dasatinib | 0.3499723 | 0.8178090 | 0.350 | NA | NA |
| GATA1 | dasatinib | 0.3512636 | 0.8178090 | 0.351 | NA | NA |
| PAX5 | dasatinib | 0.3632617 | 0.8178090 | 0.363 | NA | NA |
| SF1 | dasatinib | 0.3774403 | 0.8178090 | 0.377 | NA | NA |
| PDGFB | dasatinib | 0.3792939 | 0.8178090 | 0.379 | NA | NA |
| KRAS | dasatinib | 0.3806744 | 0.8178090 | 0.381 | NA | NA |
| BCORL1 | dasatinib | 0.3812942 | 0.8178090 | 0.381 | NA | NA |
| PIK3CA | dasatinib | 0.3837150 | 0.8178090 | 0.384 | NA | NA |
| BRCA1 | dasatinib | 0.3928660 | 0.8178090 | 0.393 | NA | NA |
| ALK | dasatinib | 0.3952274 | 0.8178090 | 0.395 | NA | NA |
| FLCN | dasatinib | 0.4143515 | 0.8178090 | 0.414 | NA | NA |
| ABL1 | dasatinib | 0.4250747 | 0.8178090 | 0.425 | NA | NA |
| UGT1A1 | dasatinib | 0.4335809 | 0.8178090 | 0.434 | NA | NA |
| GATA3 | dasatinib | 0.4405211 | 0.8178090 | 0.441 | NA | NA |
| RAD21 | dasatinib | 0.4407374 | 0.8178090 | 0.441 | NA | NA |
| CYP19A1 | dasatinib | 0.4547296 | 0.8178090 | 0.455 | NA | NA |
| CSF3R | dasatinib | 0.4567258 | 0.8178090 | 0.457 | NA | NA |
| MPL | dasatinib | 0.4578876 | 0.8178090 | 0.458 | NA | NA |
| IDH1 | dasatinib | 0.4613506 | 0.8178090 | 0.461 | NA | NA |
| MYCN | dasatinib | 0.4613506 | 0.8178090 | 0.461 | NA | NA |
| SF3B1 | dasatinib | 0.4651305 | 0.8178090 | 0.465 | NA | NA |
| TP53 | dasatinib | 0.4684244 | 0.8178090 | 0.468 | NA | NA |
| PTCH1 | dasatinib | 0.4723552 | 0.8178090 | 0.472 | NA | NA |
| SF3B1 | erlotinib | 0.2824110 | 0.8179261 | 0.2824 | NA | NA |
| RAD21 | erlotinib | 0.2906403 | 0.8179261 | 0.2906 | NA | NA |
| CDKN2A | erlotinib | 0.2916190 | 0.8179261 | 0.2916 | NA | NA |
| PIK3CA | erlotinib | 0.3286540 | 0.8179261 | 0.3287 | NA | NA |
| WHSC1 | erlotinib | 0.3322629 | 0.8179261 | 0.3323 | NA | NA |
| CTCF | erlotinib | 0.3389875 | 0.8179261 | 0.3390 | NA | NA |
| SF1 | erlotinib | 0.3481404 | 0.8179261 | 0.3481 | NA | NA |
| PDCD1 | erlotinib | 0.3556069 | 0.8179261 | 0.3556 | NA | NA |
| IKZF1 | erlotinib | 0.3582382 | 0.8179261 | 0.3582 | NA | NA |
| XPO1 | erlotinib | 0.3661029 | 0.8179261 | 0.3661 | NA | NA |
| CDK6 | erlotinib | 0.3864721 | 0.8179261 | 0.3865 | NA | NA |
| AKT3 | erlotinib | 0.3944367 | 0.8179261 | 0.3944 | NA | NA |
| IDH1 | erlotinib | 0.3944367 | 0.8179261 | 0.3944 | NA | NA |
| MYCN | erlotinib | 0.3944367 | 0.8179261 | 0.3944 | NA | NA |
| U2AF1 | erlotinib | 0.3944367 | 0.8179261 | 0.3944 | NA | NA |
| ASXL1 | erlotinib | 0.3979892 | 0.8179261 | 0.3980 | NA | NA |
| KIT | erlotinib | 0.4010455 | 0.8179261 | 0.4010 | NA | NA |
| BRCA1 | erlotinib | 0.4046403 | 0.8179261 | 0.4046 | NA | NA |
| ERBB2 | erlotinib | 0.4285389 | 0.8179261 | 0.4285 | NA | NA |
| KMT2A | erlotinib | 0.4299866 | 0.8179261 | 0.4300 | NA | NA |
| BTK | erlotinib | 0.4357267 | 0.8179261 | 0.4357 | NA | NA |
| CYP19A1 | erlotinib | 0.4583847 | 0.8179261 | 0.4584 | NA | NA |
| DNMT3A | erlotinib | 0.4620527 | 0.8179261 | 0.4621 | NA | NA |
| TP53 | erlotinib | 0.4662703 | 0.8179261 | 0.4663 | NA | NA |
| BRAF | erlotinib | 0.4662981 | 0.8179261 | 0.4663 | NA | NA |
| NOTCH1 | erlotinib | 0.4838940 | 0.8179261 | 0.4839 | NA | NA |
| CSF3R | erlotinib | 0.4879427 | 0.8179261 | 0.4879 | NA | NA |
| KRAS | erlotinib | 0.4886809 | 0.8179261 | 0.4887 | NA | NA |
| TSC2 | erlotinib | 0.4915604 | 0.8179261 | 0.4916 | NA | NA |
| AR | erlotinib | 0.4934194 | 0.8179261 | 0.4934 | NA | NA |
| PHF6 | erlotinib | 0.4975229 | 0.8179261 | 0.4975 | NA | NA |
| MAP2K1 | erlotinib | 0.4978681 | 0.8179261 | 0.4979 | NA | NA |
| CREBBP | tretinoin | 0.5236971 | 0.8202484 | 0.5237 | NA | NA |
| PRPF8 | cabozantinib | 0.5214349 | 0.8205825 | 0.5214 | NA | NA |
| CSF3R | cabozantinib | 0.5261751 | 0.8205825 | 0.5262 | NA | NA |
| BCOR | dasatinib | 0.4835917 | 0.8211459 | 0.484 | NA | NA |
| CDK6 | dasatinib | 0.5013750 | 0.8211459 | 0.501 | NA | NA |
| ATM | dasatinib | 0.5070758 | 0.8211459 | 0.507 | NA | NA |
| SETD2 | dasatinib | 0.5131984 | 0.8211459 | 0.513 | NA | NA |
| MYD88 | dasatinib | 0.5156798 | 0.8211459 | 0.516 | NA | NA |
| EZH2 | dasatinib | 0.5167556 | 0.8211459 | 0.517 | NA | NA |
| GNB1 | lapatinib | 0.0188968 | 0.8231437 | 0.0189 |
|
NA |
| DPYD | lapatinib | 0.0212882 | 0.8231437 | 0.0213 |
|
NA |
| CBL | imatinib | 0.5322515 | 0.8232156 | 0.532 | NA | NA |
| TSC2 | imatinib | 0.5394738 | 0.8234074 | 0.539 | NA | NA |
| STAG2 | erlotinib | 0.5108704 | 0.8236516 | 0.5109 | NA | NA |
| SMC3 | erlotinib | 0.5156776 | 0.8236516 | 0.5157 | NA | NA |
| JAK3 | cabozantinib | 0.5344359 | 0.8236600 | 0.5344 | NA | NA |
| AR | imatinib | 0.5689905 | 0.8240377 | 0.569 | NA | NA |
| AKT3 | imatinib | 0.5699859 | 0.8240377 | 0.570 | NA | NA |
| CDK6 | imatinib | 0.5699859 | 0.8240377 | 0.570 | NA | NA |
| FGFR1 | imatinib | 0.5744946 | 0.8240377 | 0.574 | NA | NA |
| STAT3 | imatinib | 0.5754057 | 0.8240377 | 0.575 | NA | NA |
| MYD88 | alectinib | 0.4215902 | 0.8243031 | 0.4216 | NA | NA |
| EGFR | temozolomide | 0.5669345 | 0.8252046 | 0.56693 | NA | NA |
| ERBB4 | gefitinib | 0.1599159 | 0.8258335 | 0.1599 | NA | NA |
| EGFR | gefitinib | 0.1651667 | 0.8258335 | 0.1652 | NA | NA |
| SMC1A | alectinib | 0.4329711 | 0.8276602 | 0.4330 | NA | NA |
| ZRSR2 | alectinib | 0.4359432 | 0.8276602 | 0.4359 | NA | NA |
| ERBB2 | alectinib | 0.4455420 | 0.8277525 | 0.4455 | NA | NA |
| PDGFB | alectinib | 0.4572960 | 0.8277525 | 0.4573 | NA | NA |
| TET2 | alectinib | 0.4641646 | 0.8277525 | 0.4642 | NA | NA |
| XPO1 | alectinib | 0.4657556 | 0.8277525 | 0.4658 | NA | NA |
| GATA2 | alectinib | 0.4737183 | 0.8277525 | 0.4737 | NA | NA |
| CDK6 | alectinib | 0.4739041 | 0.8277525 | 0.4739 | NA | NA |
| AKT1 | cabozantinib | 0.5467795 | 0.8282849 | 0.5468 | NA | NA |
| STAT3 | cabozantinib | 0.5530778 | 0.8282849 | 0.5531 | NA | NA |
| GATA3 | cabozantinib | 0.5564051 | 0.8282849 | 0.5564 | NA | NA |
| NT5C2 | docetaxel | 0.4447563 | 0.8291024 | 0.44476 | NA | NA |
| SRSF2 | docetaxel | 0.4573914 | 0.8291024 | 0.45739 | NA | NA |
| BTK | docetaxel | 0.4588269 | 0.8291024 | 0.45883 | NA | NA |
| MAP2K2 | docetaxel | 0.4671915 | 0.8291024 | 0.46719 | NA | NA |
| CD79B | docetaxel | 0.4739139 | 0.8291024 | 0.47391 | NA | NA |
| CYP19A1 | docetaxel | 0.4847190 | 0.8291024 | 0.48472 | NA | NA |
| RIT1 | docetaxel | 0.4934091 | 0.8291024 | 0.49341 | NA | NA |
| SSX1 | docetaxel | 0.4946266 | 0.8291024 | 0.49463 | NA | NA |
| KMT2A | docetaxel | 0.4952628 | 0.8291024 | 0.49526 | NA | NA |
| CSF3R | docetaxel | 0.4974614 | 0.8291024 | 0.49746 | NA | NA |
| G6PD | erlotinib | 0.5348254 | 0.8301554 | 0.5348 | NA | NA |
| JAK3 | erlotinib | 0.5363347 | 0.8301554 | 0.5363 | NA | NA |
| MYD88 | erlotinib | 0.5580136 | 0.8301554 | 0.5580 | NA | NA |
| BCOR | erlotinib | 0.5633547 | 0.8301554 | 0.5634 | NA | NA |
| TSC1 | erlotinib | 0.5633547 | 0.8301554 | 0.5634 | NA | NA |
| EGF | erlotinib | 0.5636517 | 0.8301554 | 0.5637 | NA | NA |
| JAK2 | erlotinib | 0.5702807 | 0.8301554 | 0.5703 | NA | NA |
| CBLB | temozolomide | 0.5787407 | 0.8331322 | 0.57874 | NA | NA |
| PDGFRA | temozolomide | 0.5883211 | 0.8339970 | 0.58832 | NA | NA |
| PTEN | temozolomide | 0.5920742 | 0.8339970 | 0.59207 | NA | NA |
| ASXL1 | docetaxel | 0.5112416 | 0.8340082 | 0.51124 | NA | NA |
| DPYD | docetaxel | 0.5183010 | 0.8340082 | 0.51830 | NA | NA |
| MET | docetaxel | 0.5196512 | 0.8340082 | 0.51965 | NA | NA |
| RET | nilotinib | 0.5840052 | 0.8362659 | 0.5840 | NA | NA |
| MGMT | nilotinib | 0.5978288 | 0.8362659 | 0.5978 | NA | NA |
| SMC1A | nilotinib | 0.5984846 | 0.8362659 | 0.5985 | NA | NA |
| CEBPA | nilotinib | 0.6007708 | 0.8362659 | 0.6008 | NA | NA |
| SMC3 | nilotinib | 0.6046846 | 0.8362659 | 0.6047 | NA | NA |
| SRSF2 | rucaparib | 0.3768031 | 0.8366305 | 0.377 | NA | NA |
| CBL | docetaxel | 0.5357729 | 0.8390025 | 0.53577 | NA | NA |
| TET2 | docetaxel | 0.5434908 | 0.8390025 | 0.54349 | NA | NA |
| SETBP1 | docetaxel | 0.5442333 | 0.8390025 | 0.54423 | NA | NA |
| WT1 | docetaxel | 0.5485785 | 0.8390025 | 0.54858 | NA | NA |
| TSC2 | cabozantinib | 0.5710996 | 0.8406072 | 0.5711 | NA | NA |
| CDK4 | dasatinib | 0.5363244 | 0.8407248 | 0.536 | NA | NA |
| STAT3 | temozolomide | 0.6037625 | 0.8414137 | 0.60376 | NA | NA |
| CDK4 | temozolomide | 0.6106364 | 0.8420355 | 0.61064 | NA | NA |
| CTCF | trametinib | 0.4472654 | 0.8426740 | 0.44727 | NA | NA |
| ALK | cabozantinib | 0.5795396 | 0.8435521 | 0.5795 | NA | NA |
| TSC2 | dasatinib | 0.5568736 | 0.8462853 | 0.557 | NA | NA |
| PIGA | dasatinib | 0.5637000 | 0.8462853 | 0.564 | NA | NA |
| PRPF40B | dasatinib | 0.5822601 | 0.8462853 | 0.582 | NA | NA |
| TET2 | dasatinib | 0.5882617 | 0.8462853 | 0.588 | NA | NA |
| CRLF2 | dasatinib | 0.5887259 | 0.8462853 | 0.589 | NA | NA |
| KMT2A | dasatinib | 0.5908858 | 0.8462853 | 0.591 | NA | NA |
| FGFR1 | dasatinib | 0.5933885 | 0.8462853 | 0.593 | NA | NA |
| CXCR4 | dasatinib | 0.5982362 | 0.8462853 | 0.598 | NA | NA |
| HRAS | trametinib | 0.4570029 | 0.8470273 | 0.45700 | NA | NA |
| MGMT | trametinib | 0.4735520 | 0.8470273 | 0.47355 | NA | NA |
| SETD2 | trametinib | 0.4755931 | 0.8470273 | 0.47559 | NA | NA |
| PTCH1 | trametinib | 0.4756384 | 0.8470273 | 0.47564 | NA | NA |
| SMC3 | lapatinib | 0.0337864 | 0.8483482 | 0.0338 |
|
NA |
| PAX8 | lapatinib | 0.0512666 | 0.8483482 | 0.0513 | NA | NA |
| EZH2 | lapatinib | 0.0555983 | 0.8483482 | 0.0556 | NA | NA |
| NCOA2 | lapatinib | 0.0614925 | 0.8483482 | 0.0615 | NA | NA |
| BRCA2 | lapatinib | 0.0716745 | 0.8483482 | 0.0717 | NA | NA |
| RPL10 | lapatinib | 0.0958239 | 0.8483482 | 0.0958 | NA | NA |
| MET | lapatinib | 0.0972319 | 0.8483482 | 0.0972 | NA | NA |
| FLCN | lapatinib | 0.0985096 | 0.8483482 | 0.0985 | NA | NA |
| RUNX1 | lapatinib | 0.1014759 | 0.8483482 | 0.1015 | NA | NA |
| CBL | lapatinib | 0.1099732 | 0.8483482 | 0.1100 | NA | NA |
| CRLF2 | lapatinib | 0.1138543 | 0.8483482 | 0.1139 | NA | NA |
| NRAS | lapatinib | 0.1166057 | 0.8483482 | 0.1166 | NA | NA |
| ERBB2 | lapatinib | 0.1230985 | 0.8483482 | 0.1231 | NA | NA |
| GATA3 | lapatinib | 0.1247292 | 0.8483482 | 0.1247 | NA | NA |
| UGT1A1 | lapatinib | 0.1409522 | 0.8483482 | 0.1410 | NA | NA |
| ALK | lapatinib | 0.1428928 | 0.8483482 | 0.1429 | NA | NA |
| NOTCH1 | lapatinib | 0.1462669 | 0.8483482 | 0.1463 | NA | NA |
| CDK6 | tretinoin | 0.5504161 | 0.8488081 | 0.5504 | NA | NA |
| CYP19A1 | tretinoin | 0.5549899 | 0.8488081 | 0.5550 | NA | NA |
| MPL | gefitinib | 0.1763514 | 0.8490991 | 0.1764 | NA | NA |
| PTCH1 | palbociclib | 0.3180803 | 0.8503779 | 0.3181 | NA | NA |
| NRAS | dasatinib | 0.6085294 | 0.8504748 | 0.609 | NA | NA |
| WT1 | imatinib | 0.6012342 | 0.8505264 | 0.601 | NA | NA |
| SF1 | tretinoin | 0.5723561 | 0.8505951 | 0.5724 | NA | NA |
| STAG2 | tretinoin | 0.5772249 | 0.8505951 | 0.5772 | NA | NA |
| GNA11 | tretinoin | 0.5858785 | 0.8505951 | 0.5859 | NA | NA |
| EGFR | tretinoin | 0.5940328 | 0.8505951 | 0.5940 | NA | NA |
| U2AF1 | tretinoin | 0.6080591 | 0.8505951 | 0.6081 | NA | NA |
| DNAJB1 | tretinoin | 0.6098927 | 0.8505951 | 0.6099 | NA | NA |
| DDIT3 | tretinoin | 0.6226906 | 0.8505951 | 0.6227 | NA | NA |
| DNMT3A | tretinoin | 0.6240726 | 0.8505951 | 0.6241 | NA | NA |
| EGF | tretinoin | 0.6298346 | 0.8505951 | 0.6298 | NA | NA |
| IDH1 | tretinoin | 0.6327016 | 0.8505951 | 0.6327 | NA | NA |
| BCOR | tretinoin | 0.6346058 | 0.8505951 | 0.6346 | NA | NA |
| PAX5 | tretinoin | 0.6346748 | 0.8505951 | 0.6347 | NA | NA |
| CDK4 | cabozantinib | 0.5910559 | 0.8508607 | 0.5911 | NA | NA |
| MPL | afatinib | 0.3387786 | 0.8510648 | 0.3388 | NA | NA |
| KIT | afatinib | 0.3580267 | 0.8510648 | 0.3580 | NA | NA |
| SETBP1 | afatinib | 0.3588256 | 0.8510648 | 0.3588 | NA | NA |
| CXCR4 | afatinib | 0.3626374 | 0.8510648 | 0.3626 | NA | NA |
| FANCL | afatinib | 0.3712677 | 0.8510648 | 0.3713 | NA | NA |
| SF1 | afatinib | 0.3735649 | 0.8510648 | 0.3736 | NA | NA |
| ASXL1 | afatinib | 0.3758930 | 0.8510648 | 0.3759 | NA | NA |
| SMO | afatinib | 0.3813865 | 0.8510648 | 0.3814 | NA | NA |
| ATM | afatinib | 0.3862525 | 0.8510648 | 0.3863 | NA | NA |
| MDM2 | nilotinib | 0.6317840 | 0.8529826 | 0.6318 | NA | NA |
| FBXW7 | nilotinib | 0.6329663 | 0.8529826 | 0.6330 | NA | NA |
| PAX8 | nilotinib | 0.6400247 | 0.8529826 | 0.6400 | NA | NA |
| FGFR1 | nilotinib | 0.6591234 | 0.8529826 | 0.6591 | NA | NA |
| CREBBP | nilotinib | 0.6672208 | 0.8529826 | 0.6672 | NA | NA |
| BRCA2 | nilotinib | 0.6739857 | 0.8529826 | 0.6740 | NA | NA |
| CDKN2A | nilotinib | 0.6769401 | 0.8529826 | 0.6769 | NA | NA |
| CRLF2 | nilotinib | 0.6773888 | 0.8529826 | 0.6774 | NA | NA |
| PAX5 | nilotinib | 0.6809647 | 0.8529826 | 0.6810 | NA | NA |
| CBLB | nilotinib | 0.6856568 | 0.8529826 | 0.6857 | NA | NA |
| ERBB4 | nilotinib | 0.6889474 | 0.8529826 | 0.6889 | NA | NA |
| SMC1A | gefitinib | 0.1838148 | 0.8534259 | 0.1838 | NA | NA |
| BCORL1 | palbociclib | 0.3287607 | 0.8547330 | 0.3288 | NA | NA |
| PDGFB | palbociclib | 0.3327587 | 0.8547330 | 0.3328 | NA | NA |
| CYP19A1 | cabozantinib | 0.6024929 | 0.8576230 | 0.6025 | NA | NA |
| CD79B | cabozantinib | 0.6190926 | 0.8576230 | 0.6191 | NA | NA |
| MYCN | cabozantinib | 0.6193520 | 0.8576230 | 0.6194 | NA | NA |
| EED | cabozantinib | 0.6219404 | 0.8576230 | 0.6219 | NA | NA |
| SH2B3 | midostaurin | 0.3733494 | 0.8580485 | 0.3733 | NA | NA |
| CDK4 | dabrafenib | 0.3540843 | 0.8589824 | 0.35408 | NA | NA |
| STAG2 | midostaurin | 0.3813979 | 0.8590892 | 0.3814 | NA | NA |
| AR | midostaurin | 0.3869180 | 0.8590892 | 0.3869 | NA | NA |
| ABL1 | erlotinib | 0.5985108 | 0.8603592 | 0.5985 | NA | NA |
| PIK3CA | temozolomide | 0.6319837 | 0.8623944 | 0.63198 | NA | NA |
| FANCL | crizotinib | 0.2386699 | 0.8641806 | 0.2387 | NA | NA |
| MPL | crizotinib | 0.2519796 | 0.8641806 | 0.2520 | NA | NA |
| UGT1A1 | crizotinib | 0.2625570 | 0.8641806 | 0.2626 | NA | NA |
| DNAJB1 | crizotinib | 0.2676694 | 0.8641806 | 0.2677 | NA | NA |
| AR | crizotinib | 0.2791398 | 0.8641806 | 0.2791 | NA | NA |
| RIT1 | crizotinib | 0.3182654 | 0.8641806 | 0.3183 | NA | NA |
| SMC1A | crizotinib | 0.3195953 | 0.8641806 | 0.3196 | NA | NA |
| NOTCH2 | crizotinib | 0.3297967 | 0.8641806 | 0.3298 | NA | NA |
| PRPF8 | crizotinib | 0.3336126 | 0.8641806 | 0.3336 | NA | NA |
| AKT2 | crizotinib | 0.3358098 | 0.8641806 | 0.3358 | NA | NA |
| NT5C2 | crizotinib | 0.3358098 | 0.8641806 | 0.3358 | NA | NA |
| NRAS | crizotinib | 0.3513508 | 0.8641806 | 0.3514 | NA | NA |
| PIGA | crizotinib | 0.3571747 | 0.8641806 | 0.3572 | NA | NA |
| STAG2 | crizotinib | 0.3627363 | 0.8641806 | 0.3627 | NA | NA |
| IKZF1 | crizotinib | 0.3663689 | 0.8641806 | 0.3664 | NA | NA |
| PTEN | crizotinib | 0.3676751 | 0.8641806 | 0.3677 | NA | NA |
| ALK | crizotinib | 0.3700920 | 0.8641806 | 0.3701 | NA | NA |
| NPM1 | crizotinib | 0.3719543 | 0.8641806 | 0.3720 | NA | NA |
| FGFR2 | crizotinib | 0.3724916 | 0.8641806 | 0.3725 | NA | NA |
| TSC1 | docetaxel | 0.5725527 | 0.8654867 | 0.57255 | NA | NA |
| RIT1 | cabozantinib | 0.6344014 | 0.8656936 | 0.6344 | NA | NA |
| STAG2 | afatinib | 0.3995949 | 0.8657890 | 0.3996 | NA | NA |
| PTEN | erlotinib | 0.6294097 | 0.8671968 | 0.6294 | NA | NA |
| SMO | erlotinib | 0.6333592 | 0.8671968 | 0.6334 | NA | NA |
| PML | erlotinib | 0.6360548 | 0.8671968 | 0.6361 | NA | NA |
| IDH2 | erlotinib | 0.6634451 | 0.8671968 | 0.6634 | NA | NA |
| CTNNB1 | erlotinib | 0.6709344 | 0.8671968 | 0.6709 | NA | NA |
| PDGFRA | erlotinib | 0.6824019 | 0.8671968 | 0.6824 | NA | NA |
| CD79B | erlotinib | 0.6861034 | 0.8671968 | 0.6861 | NA | NA |
| DNAJB1 | erlotinib | 0.6861034 | 0.8671968 | 0.6861 | NA | NA |
| GNAQ | erlotinib | 0.6861034 | 0.8671968 | 0.6861 | NA | NA |
| MPL | erlotinib | 0.6862166 | 0.8671968 | 0.6862 | NA | NA |
| NOTCH2 | erlotinib | 0.6862166 | 0.8671968 | 0.6862 | NA | NA |
| ASXL1 | ruxolitinib | 0.3708094 | 0.8674292 | 0.3708 | NA | NA |
| JAK2 | gefitinib | 0.1997501 | 0.8676691 | 0.1998 | NA | NA |
| ESR1 | gefitinib | 0.2002313 | 0.8676691 | 0.2002 | NA | NA |
| MAP2K2 | dabrafenib | 0.3682429 | 0.8678565 | 0.36824 | NA | NA |
| NCOA2 | dabrafenib | 0.3782220 | 0.8678565 | 0.37822 | NA | NA |
| WT1 | dabrafenib | 0.3899972 | 0.8678565 | 0.39000 | NA | NA |
| CTCF | dabrafenib | 0.3923327 | 0.8678565 | 0.39233 | NA | NA |
| JAK3 | dabrafenib | 0.4085791 | 0.8678565 | 0.40858 | NA | NA |
| FGFR3 | dabrafenib | 0.4155330 | 0.8678565 | 0.41553 | NA | NA |
| MPL | dabrafenib | 0.4381599 | 0.8678565 | 0.43816 | NA | NA |
| STAG2 | dabrafenib | 0.4388822 | 0.8678565 | 0.43888 | NA | NA |
| ABL1 | dabrafenib | 0.4415642 | 0.8678565 | 0.44156 | NA | NA |
| IKZF1 | dabrafenib | 0.4423625 | 0.8678565 | 0.44236 | NA | NA |
| ASXL1 | dabrafenib | 0.4430462 | 0.8678565 | 0.44305 | NA | NA |
| AKT1 | dabrafenib | 0.4490980 | 0.8678565 | 0.44910 | NA | NA |
| PDGFRA | dabrafenib | 0.4498286 | 0.8678565 | 0.44983 | NA | NA |
| ETV6 | dabrafenib | 0.4562090 | 0.8678565 | 0.45621 | NA | NA |
| CDKN2A | dabrafenib | 0.4571153 | 0.8678565 | 0.45712 | NA | NA |
| CEBPA | temozolomide | 0.6502677 | 0.8687880 | 0.65027 | NA | NA |
| MGMT | temozolomide | 0.6634570 | 0.8687880 | 0.66346 | NA | NA |
| DDIT3 | temozolomide | 0.6680811 | 0.8687880 | 0.66808 | NA | NA |
| GATA2 | temozolomide | 0.6681305 | 0.8687880 | 0.66813 | NA | NA |
| ROS1 | temozolomide | 0.6751390 | 0.8687880 | 0.67514 | NA | NA |
| SH2B3 | temozolomide | 0.6764609 | 0.8687880 | 0.67646 | NA | NA |
| ERBB2 | ruxolitinib | 0.3785733 | 0.8688783 | 0.3786 | NA | NA |
| CXCR4 | ruxolitinib | 0.3846942 | 0.8688783 | 0.3847 | NA | NA |
| PTEN | trametinib | 0.4995948 | 0.8688946 | 0.49959 | NA | NA |
| GATA1 | trametinib | 0.5114237 | 0.8688946 | 0.51142 | NA | NA |
| FANCL | trametinib | 0.5123217 | 0.8688946 | 0.51232 | NA | NA |
| CDK4 | trametinib | 0.5235152 | 0.8688946 | 0.52352 | NA | NA |
| KMT2A | trametinib | 0.5242068 | 0.8688946 | 0.52421 | NA | NA |
| PDGFB | trametinib | 0.5280206 | 0.8688946 | 0.52802 | NA | NA |
| PDGFRA | docetaxel | 0.5828922 | 0.8709883 | 0.58289 | NA | NA |
| CDK6 | gefitinib | 0.2081255 | 0.8727844 | 0.2081 | NA | NA |
| SMC3 | palbociclib | 0.3538314 | 0.8731789 | 0.3538 | NA | NA |
| TSC1 | palbociclib | 0.3704875 | 0.8731789 | 0.3705 | NA | NA |
| SMO | palbociclib | 0.3726724 | 0.8731789 | 0.3727 | NA | NA |
| G6PD | palbociclib | 0.3728013 | 0.8731789 | 0.3728 | NA | NA |
| AKT1 | palbociclib | 0.3961746 | 0.8731789 | 0.3962 | NA | NA |
| NPM1 | palbociclib | 0.3996308 | 0.8731789 | 0.3996 | NA | NA |
| WT1 | palbociclib | 0.4072870 | 0.8731789 | 0.4073 | NA | NA |
| PDGFRA | palbociclib | 0.4083491 | 0.8731789 | 0.4083 | NA | NA |
| PTPN11 | palbociclib | 0.4211924 | 0.8731789 | 0.4212 | NA | NA |
| GNB1 | palbociclib | 0.4395108 | 0.8731789 | 0.4395 | NA | NA |
| GNAS | palbociclib | 0.4431247 | 0.8731789 | 0.4431 | NA | NA |
| IDH1 | palbociclib | 0.4458469 | 0.8731789 | 0.4458 | NA | NA |
| GNA11 | palbociclib | 0.4475585 | 0.8731789 | 0.4476 | NA | NA |
| SF1 | palbociclib | 0.4523993 | 0.8731789 | 0.4524 | NA | NA |
| CSF3R | palbociclib | 0.4595627 | 0.8731789 | 0.4596 | NA | NA |
| ERBB3 | palbociclib | 0.4724268 | 0.8731789 | 0.4724 | NA | NA |
| SF3B1 | palbociclib | 0.4773083 | 0.8731789 | 0.4773 | NA | NA |
| CTNNB1 | palbociclib | 0.4793518 | 0.8731789 | 0.4794 | NA | NA |
| WHSC1 | palbociclib | 0.4845512 | 0.8731789 | 0.4846 | NA | NA |
| JAK3 | palbociclib | 0.4969978 | 0.8731789 | 0.4970 | NA | NA |
| PIK3CA | palbociclib | 0.5003636 | 0.8731789 | 0.5004 | NA | NA |
| KIT | palbociclib | 0.5134101 | 0.8731789 | 0.5134 | NA | NA |
| EML4 | palbociclib | 0.5149978 | 0.8731789 | 0.5150 | NA | NA |
| CD79B | palbociclib | 0.5185060 | 0.8731789 | 0.5185 | NA | NA |
| DNMT3A | palbociclib | 0.5222786 | 0.8731789 | 0.5223 | NA | NA |
| ASXL1 | palbociclib | 0.5246346 | 0.8731789 | 0.5246 | NA | NA |
| RUNX1 | palbociclib | 0.5310874 | 0.8731789 | 0.5311 | NA | NA |
| CXCR4 | palbociclib | 0.5381348 | 0.8731789 | 0.5381 | NA | NA |
| PIGA | palbociclib | 0.5433316 | 0.8731789 | 0.5433 | NA | NA |
| MPL | palbociclib | 0.5554405 | 0.8731789 | 0.5554 | NA | NA |
| PAX8 | palbociclib | 0.5648846 | 0.8731789 | 0.5649 | NA | NA |
| JAK2 | palbociclib | 0.5675682 | 0.8731789 | 0.5676 | NA | NA |
| FGFR3 | palbociclib | 0.5685115 | 0.8731789 | 0.5685 | NA | NA |
| CDC73 | palbociclib | 0.5776497 | 0.8731789 | 0.5776 | NA | NA |
| AKT3 | palbociclib | 0.5783610 | 0.8731789 | 0.5784 | NA | NA |
| CDK6 | palbociclib | 0.5875801 | 0.8731789 | 0.5876 | NA | NA |
| DNAJB1 | palbociclib | 0.5878256 | 0.8731789 | 0.5878 | NA | NA |
| NOTCH1 | palbociclib | 0.5985739 | 0.8731789 | 0.5986 | NA | NA |
| CBL | palbociclib | 0.6031882 | 0.8731789 | 0.6032 | NA | NA |
| XPO1 | palbociclib | 0.6065594 | 0.8731789 | 0.6066 | NA | NA |
| MET | temozolomide | 0.6917583 | 0.8740358 | 0.69176 | NA | NA |
| ABL1 | temozolomide | 0.6987934 | 0.8740358 | 0.69879 | NA | NA |
| CRLF2 | temozolomide | 0.7018756 | 0.8740358 | 0.70188 | NA | NA |
| KRAS | temozolomide | 0.7150718 | 0.8740358 | 0.71507 | NA | NA |
| NRAS | temozolomide | 0.7197845 | 0.8740358 | 0.71978 | NA | NA |
| HRAS | temozolomide | 0.7205791 | 0.8740358 | 0.72058 | NA | NA |
| DPYD | alectinib | 0.5225472 | 0.8743299 | 0.5225 | NA | NA |
| PHF6 | alectinib | 0.5336040 | 0.8743299 | 0.5336 | NA | NA |
| AR | alectinib | 0.5352746 | 0.8743299 | 0.5353 | NA | NA |
| ETV6 | alectinib | 0.5387069 | 0.8743299 | 0.5387 | NA | NA |
| MPL | alectinib | 0.5402344 | 0.8743299 | 0.5402 | NA | NA |
| PAX5 | alectinib | 0.5518586 | 0.8743299 | 0.5519 | NA | NA |
| ERBB3 | alectinib | 0.5530430 | 0.8743299 | 0.5530 | NA | NA |
| ATM | alectinib | 0.5548611 | 0.8743299 | 0.5549 | NA | NA |
| MAP2K2 | alectinib | 0.5608883 | 0.8743299 | 0.5609 | NA | NA |
| U2AF1 | alectinib | 0.5756944 | 0.8743299 | 0.5757 | NA | NA |
| GNA11 | alectinib | 0.5790606 | 0.8743299 | 0.5791 | NA | NA |
| DNAJB1 | alectinib | 0.5806618 | 0.8743299 | 0.5807 | NA | NA |
| SMO | lapatinib | 0.1785842 | 0.8745041 | 0.1786 | NA | NA |
| SF3B1 | lapatinib | 0.1846865 | 0.8745041 | 0.1847 | NA | NA |
| CXCR4 | lapatinib | 0.1971848 | 0.8745041 | 0.1972 | NA | NA |
| AR | lapatinib | 0.2135960 | 0.8745041 | 0.2136 | NA | NA |
| DNAJB1 | lapatinib | 0.2180070 | 0.8745041 | 0.2180 | NA | NA |
| SMC1A | lapatinib | 0.2210226 | 0.8745041 | 0.2210 | NA | NA |
| CDK4 | lapatinib | 0.2244316 | 0.8745041 | 0.2244 | NA | NA |
| TET2 | lapatinib | 0.2251236 | 0.8745041 | 0.2251 | NA | NA |
| RIT1 | lapatinib | 0.2253423 | 0.8745041 | 0.2253 | NA | NA |
| ABL1 | lapatinib | 0.2342922 | 0.8745041 | 0.2343 | NA | NA |
| CALR | lapatinib | 0.2514271 | 0.8745041 | 0.2514 | NA | NA |
| MGMT | lapatinib | 0.2514271 | 0.8745041 | 0.2514 | NA | NA |
| PDGFB | lapatinib | 0.2633229 | 0.8745041 | 0.2633 | NA | NA |
| NPM1 | lapatinib | 0.2737483 | 0.8745041 | 0.2737 | NA | NA |
| ERBB4 | lapatinib | 0.2819297 | 0.8745041 | 0.2819 | NA | NA |
| BCORL1 | lapatinib | 0.2829109 | 0.8745041 | 0.2829 | NA | NA |
| CD79B | lapatinib | 0.2864755 | 0.8745041 | 0.2865 | NA | NA |
| GNAQ | lapatinib | 0.2864755 | 0.8745041 | 0.2865 | NA | NA |
| DNMT3A | ruxolitinib | 0.4082055 | 0.8746635 | 0.4082 | NA | NA |
| SMO | ruxolitinib | 0.4108655 | 0.8746635 | 0.4109 | NA | NA |
| NOTCH2 | ruxolitinib | 0.4112888 | 0.8746635 | 0.4113 | NA | NA |
| SRSF2 | ruxolitinib | 0.4243256 | 0.8746635 | 0.4243 | NA | NA |
| GATA1 | ruxolitinib | 0.4461233 | 0.8746635 | 0.4461 | NA | NA |
| EGF | ruxolitinib | 0.4493943 | 0.8746635 | 0.4494 | NA | NA |
| BCOR | ruxolitinib | 0.4496662 | 0.8746635 | 0.4497 | NA | NA |
| SF1 | ruxolitinib | 0.4512242 | 0.8746635 | 0.4512 | NA | NA |
| DDIT3 | ruxolitinib | 0.4573678 | 0.8746635 | 0.4574 | NA | NA |
| CREBBP | ruxolitinib | 0.4719661 | 0.8746635 | 0.4720 | NA | NA |
| PDGFRB | ruxolitinib | 0.4765472 | 0.8746635 | 0.4765 | NA | NA |
| FANCL | ruxolitinib | 0.4784767 | 0.8746635 | 0.4785 | NA | NA |
| BRCA1 | ruxolitinib | 0.4788739 | 0.8746635 | 0.4789 | NA | NA |
| NPM1 | ruxolitinib | 0.4817234 | 0.8746635 | 0.4817 | NA | NA |
| KMT2A | ruxolitinib | 0.5043906 | 0.8746635 | 0.5044 | NA | NA |
| CBL | ruxolitinib | 0.5128995 | 0.8746635 | 0.5129 | NA | NA |
| DPYD | ruxolitinib | 0.5165164 | 0.8746635 | 0.5165 | NA | NA |
| GNA11 | ruxolitinib | 0.5187155 | 0.8746635 | 0.5187 | NA | NA |
| ETV6 | ruxolitinib | 0.5373343 | 0.8746635 | 0.5373 | NA | NA |
| IDH1 | ruxolitinib | 0.5528888 | 0.8746635 | 0.5529 | NA | NA |
| RET | ruxolitinib | 0.5597886 | 0.8746635 | 0.5598 | NA | NA |
| MDM2 | ruxolitinib | 0.5647650 | 0.8746635 | 0.5648 | NA | NA |
| BTK | ruxolitinib | 0.5677799 | 0.8746635 | 0.5678 | NA | NA |
| CDC73 | ruxolitinib | 0.5718819 | 0.8746635 | 0.5719 | NA | NA |
| TSC2 | ruxolitinib | 0.5824296 | 0.8746635 | 0.5824 | NA | NA |
| PTCH1 | ruxolitinib | 0.5835921 | 0.8746635 | 0.5836 | NA | NA |
| ESR1 | ruxolitinib | 0.5973766 | 0.8746635 | 0.5974 | NA | NA |
| HRAS | ruxolitinib | 0.5989160 | 0.8746635 | 0.5989 | NA | NA |
| GATA3 | ruxolitinib | 0.6067286 | 0.8746635 | 0.6067 | NA | NA |
| AKT3 | ruxolitinib | 0.6086854 | 0.8746635 | 0.6087 | NA | NA |
| SH2B3 | ruxolitinib | 0.6086854 | 0.8746635 | 0.6087 | NA | NA |
| GNAS | ruxolitinib | 0.6157098 | 0.8746635 | 0.6157 | NA | NA |
| NOTCH1 | ruxolitinib | 0.6220714 | 0.8746635 | 0.6221 | NA | NA |
| CSF3R | ruxolitinib | 0.6235370 | 0.8746635 | 0.6235 | NA | NA |
| PIGA | ruxolitinib | 0.6341800 | 0.8746635 | 0.6342 | NA | NA |
| GNAQ | ruxolitinib | 0.6391925 | 0.8746635 | 0.6392 | NA | NA |
| FGFR3 | ruxolitinib | 0.6425963 | 0.8746635 | 0.6426 | NA | NA |
| EGFR | ruxolitinib | 0.6447588 | 0.8746635 | 0.6448 | NA | NA |
| ERBB3 | ruxolitinib | 0.6532068 | 0.8746635 | 0.6532 | NA | NA |
| CTLA4 | ruxolitinib | 0.6543284 | 0.8746635 | 0.6543 | NA | NA |
| GATA3 | tretinoin | 0.6613899 | 0.8754881 | 0.6614 | NA | NA |
| ASXL1 | tretinoin | 0.6667178 | 0.8754881 | 0.6667 | NA | NA |
| MYCN | trametinib | 0.5389272 | 0.8757567 | 0.53893 | NA | NA |
| CTCF | midostaurin | 0.4387679 | 0.8766624 | 0.4388 | NA | NA |
| CYP19A1 | midostaurin | 0.4400719 | 0.8766624 | 0.4401 | NA | NA |
| TP53 | midostaurin | 0.4402169 | 0.8766624 | 0.4402 | NA | NA |
| JAK3 | midostaurin | 0.4827637 | 0.8766624 | 0.4828 | NA | NA |
| GNAQ | midostaurin | 0.4871146 | 0.8766624 | 0.4871 | NA | NA |
| ALK | midostaurin | 0.4971993 | 0.8766624 | 0.4972 | NA | NA |
| DDIT3 | midostaurin | 0.5062536 | 0.8766624 | 0.5063 | NA | NA |
| NOTCH2 | midostaurin | 0.5068663 | 0.8766624 | 0.5069 | NA | NA |
| SSX1 | midostaurin | 0.5081623 | 0.8766624 | 0.5082 | NA | NA |
| DPYD | midostaurin | 0.5086465 | 0.8766624 | 0.5086 | NA | NA |
| CBLB | midostaurin | 0.5224343 | 0.8766624 | 0.5224 | NA | NA |
| NRAS | midostaurin | 0.5263903 | 0.8766624 | 0.5264 | NA | NA |
| MYD88 | midostaurin | 0.5310291 | 0.8766624 | 0.5310 | NA | NA |
| DNMT3A | midostaurin | 0.5328652 | 0.8766624 | 0.5329 | NA | NA |
| SMO | midostaurin | 0.5343564 | 0.8766624 | 0.5344 | NA | NA |
| ABL1 | midostaurin | 0.5402282 | 0.8766624 | 0.5402 | NA | NA |
| STAT3 | midostaurin | 0.5403698 | 0.8766624 | 0.5404 | NA | NA |
| CXCR4 | midostaurin | 0.5422466 | 0.8766624 | 0.5422 | NA | NA |
| TSC2 | midostaurin | 0.5433441 | 0.8766624 | 0.5433 | NA | NA |
| CBL | midostaurin | 0.5442339 | 0.8766624 | 0.5442 | NA | NA |
| FLCN | midostaurin | 0.5460539 | 0.8766624 | 0.5461 | NA | NA |
| PDGFB | midostaurin | 0.5477164 | 0.8766624 | 0.5477 | NA | NA |
| KIT | midostaurin | 0.5523909 | 0.8766624 | 0.5524 | NA | NA |
| AKT2 | midostaurin | 0.5554426 | 0.8766624 | 0.5554 | NA | NA |
| SF3B1 | imatinib | 0.6360653 | 0.8767987 | 0.636 | NA | NA |
| CREBBP | imatinib | 0.6365514 | 0.8767987 | 0.637 | NA | NA |
| KRAS | imatinib | 0.6424818 | 0.8767987 | 0.642 | NA | NA |
| PDGFRA | rucaparib | 0.4016231 | 0.8768771 | 0.402 | NA | NA |
| AKT2 | gefitinib | 0.2158478 | 0.8768818 | 0.2158 | NA | NA |
| CEBPA | afatinib | 0.4120008 | 0.8780345 | 0.4120 | NA | NA |
| BRAF | temozolomide | 0.7335771 | 0.8785321 | 0.73358 | NA | NA |
| CYP19A1 | temozolomide | 0.7376987 | 0.8785321 | 0.73770 | NA | NA |
| WT1 | gefitinib | 0.2363973 | 0.8796561 | 0.2364 | NA | NA |
| PHF6 | gefitinib | 0.2574329 | 0.8796561 | 0.2574 | NA | NA |
| CDKN2A | gefitinib | 0.2634206 | 0.8796561 | 0.2634 | NA | NA |
| MAP2K2 | gefitinib | 0.2745244 | 0.8796561 | 0.2745 | NA | NA |
| CBL | gefitinib | 0.2788384 | 0.8796561 | 0.2788 | NA | NA |
| FGFR1 | gefitinib | 0.2872103 | 0.8796561 | 0.2872 | NA | NA |
| RIT1 | gefitinib | 0.3002316 | 0.8796561 | 0.3002 | NA | NA |
| TPMT | gefitinib | 0.3116629 | 0.8796561 | 0.3117 | NA | NA |
| IDH2 | gefitinib | 0.3258316 | 0.8796561 | 0.3258 | NA | NA |
| FLT3 | gefitinib | 0.3274937 | 0.8796561 | 0.3275 | NA | NA |
| ERBB3 | gefitinib | 0.3353927 | 0.8796561 | 0.3354 | NA | NA |
| SETBP1 | gefitinib | 0.3370540 | 0.8796561 | 0.3371 | NA | NA |
| CDK4 | gefitinib | 0.3394024 | 0.8796561 | 0.3394 | NA | NA |
| PRPF8 | gefitinib | 0.3503421 | 0.8796561 | 0.3503 | NA | NA |
| TET2 | gefitinib | 0.3552137 | 0.8796561 | 0.3552 | NA | NA |
| PDGFB | gefitinib | 0.3627861 | 0.8796561 | 0.3628 | NA | NA |
| SSX1 | gefitinib | 0.3647486 | 0.8796561 | 0.3647 | NA | NA |
| GNA11 | gefitinib | 0.3799164 | 0.8796561 | 0.3799 | NA | NA |
| BRCA2 | gefitinib | 0.3852457 | 0.8796561 | 0.3852 | NA | NA |
| BTK | gefitinib | 0.3953704 | 0.8796561 | 0.3954 | NA | NA |
| DNAJB1 | gefitinib | 0.3961625 | 0.8796561 | 0.3962 | NA | NA |
| MET | gefitinib | 0.3977576 | 0.8796561 | 0.3978 | NA | NA |
| JAK3 | gefitinib | 0.3982969 | 0.8796561 | 0.3983 | NA | NA |
| EZH2 | gefitinib | 0.4053278 | 0.8796561 | 0.4053 | NA | NA |
| ASXL1 | gefitinib | 0.4134771 | 0.8796561 | 0.4135 | NA | NA |
| BCOR | gefitinib | 0.4214414 | 0.8796561 | 0.4214 | NA | NA |
| BCORL1 | gefitinib | 0.4232724 | 0.8796561 | 0.4233 | NA | NA |
| AR | gefitinib | 0.4279563 | 0.8796561 | 0.4280 | NA | NA |
| KIT | gefitinib | 0.4300536 | 0.8796561 | 0.4301 | NA | NA |
| FLCN | gefitinib | 0.4366833 | 0.8796561 | 0.4367 | NA | NA |
| IKZF1 | gefitinib | 0.4416698 | 0.8796561 | 0.4417 | NA | NA |
| STAG2 | gefitinib | 0.4492901 | 0.8796561 | 0.4493 | NA | NA |
| PAX8 | gefitinib | 0.4607206 | 0.8796561 | 0.4607 | NA | NA |
| IDH1 | gefitinib | 0.4721833 | 0.8796561 | 0.4722 | NA | NA |
| PRPF40B | gefitinib | 0.4831030 | 0.8796561 | 0.4831 | NA | NA |
| CDC73 | gefitinib | 0.4859099 | 0.8796561 | 0.4859 | NA | NA |
| STAT3 | gefitinib | 0.4879455 | 0.8796561 | 0.4879 | NA | NA |
| RAD21 | gefitinib | 0.5067814 | 0.8796561 | 0.5068 | NA | NA |
| PAX5 | gefitinib | 0.5085301 | 0.8796561 | 0.5085 | NA | NA |
| BRAF | gefitinib | 0.5109860 | 0.8796561 | 0.5110 | NA | NA |
| DPYD | gefitinib | 0.5210093 | 0.8796561 | 0.5210 | NA | NA |
| NPM1 | gefitinib | 0.5227495 | 0.8796561 | 0.5227 | NA | NA |
| MDM2 | gefitinib | 0.5257801 | 0.8796561 | 0.5258 | NA | NA |
| SF1 | gefitinib | 0.5385821 | 0.8796561 | 0.5386 | NA | NA |
| CTLA4 | gefitinib | 0.5404583 | 0.8796561 | 0.5405 | NA | NA |
| GNB1 | gefitinib | 0.5488952 | 0.8796561 | 0.5489 | NA | NA |
| ROS1 | gefitinib | 0.5511895 | 0.8796561 | 0.5512 | NA | NA |
| MYCN | gefitinib | 0.5550598 | 0.8796561 | 0.5551 | NA | NA |
| CD79B | gefitinib | 0.5587538 | 0.8796561 | 0.5588 | NA | NA |
| CEBPA | gefitinib | 0.5601244 | 0.8796561 | 0.5601 | NA | NA |
| RET | gefitinib | 0.5658382 | 0.8796561 | 0.5658 | NA | NA |
| CYP19A1 | gefitinib | 0.5683932 | 0.8796561 | 0.5684 | NA | NA |
| NT5C2 | ruxolitinib | 0.6648061 | 0.8796929 | 0.6648 | NA | NA |
| MET | ruxolitinib | 0.6724758 | 0.8809433 | 0.6725 | NA | NA |
| CSF3R | crizotinib | 0.3873438 | 0.8810173 | 0.3873 | NA | NA |
| ESR1 | tretinoin | 0.6845216 | 0.8821557 | 0.6845 | NA | NA |
| FBXW7 | tretinoin | 0.6863672 | 0.8821557 | 0.6864 | NA | NA |
| GNB1 | tretinoin | 0.7042251 | 0.8821557 | 0.7042 | NA | NA |
| CTNNB1 | tretinoin | 0.7063175 | 0.8821557 | 0.7063 | NA | NA |
| CBL | tretinoin | 0.7065815 | 0.8821557 | 0.7066 | NA | NA |
| PAX8 | tretinoin | 0.7192167 | 0.8821557 | 0.7192 | NA | NA |
| CBLB | tretinoin | 0.7276859 | 0.8821557 | 0.7277 | NA | NA |
| CDK4 | tretinoin | 0.7381800 | 0.8821557 | 0.7382 | NA | NA |
| SETBP1 | tretinoin | 0.7395737 | 0.8821557 | 0.7396 | NA | NA |
| PIGA | tretinoin | 0.7420835 | 0.8821557 | 0.7421 | NA | NA |
| SETD2 | tretinoin | 0.7482992 | 0.8821557 | 0.7483 | NA | NA |
| ERBB4 | tretinoin | 0.7532253 | 0.8821557 | 0.7532 | NA | NA |
| NOTCH1 | alectinib | 0.5992984 | 0.8822458 | 0.5993 | NA | NA |
| IKZF1 | alectinib | 0.5993884 | 0.8822458 | 0.5994 | NA | NA |
| NCOA2 | midostaurin | 0.5663758 | 0.8832766 | 0.5664 | NA | NA |
| ESR1 | dasatinib | 0.6806688 | 0.8852220 | 0.681 | NA | NA |
| U2AF1 | dasatinib | 0.6894250 | 0.8852220 | 0.689 | NA | NA |
| NCOA2 | dasatinib | 0.6940632 | 0.8852220 | 0.694 | NA | NA |
| PML | dasatinib | 0.7028188 | 0.8852220 | 0.703 | NA | NA |
| TSC1 | dasatinib | 0.7033301 | 0.8852220 | 0.703 | NA | NA |
| IDH2 | dasatinib | 0.7090830 | 0.8852220 | 0.709 | NA | NA |
| JAK2 | dasatinib | 0.7103203 | 0.8852220 | 0.710 | NA | NA |
| SETBP1 | dasatinib | 0.7145822 | 0.8852220 | 0.715 | NA | NA |
| RET | dasatinib | 0.7148163 | 0.8852220 | 0.715 | NA | NA |
| BTK | dasatinib | 0.7173351 | 0.8852220 | 0.717 | NA | NA |
| PAX8 | dasatinib | 0.7173351 | 0.8852220 | 0.717 | NA | NA |
| EGF | alectinib | 0.6088652 | 0.8855398 | 0.6089 | NA | NA |
| FGFR2 | alectinib | 0.6211625 | 0.8855398 | 0.6212 | NA | NA |
| FBXW7 | alectinib | 0.6219058 | 0.8855398 | 0.6219 | NA | NA |
| ALK | erlotinib | 0.7099827 | 0.8859576 | 0.7100 | NA | NA |
| ERBB3 | erlotinib | 0.7203169 | 0.8859576 | 0.7203 | NA | NA |
| NT5C2 | erlotinib | 0.7318780 | 0.8859576 | 0.7319 | NA | NA |
| RUNX1 | erlotinib | 0.7318780 | 0.8859576 | 0.7319 | NA | NA |
| CBLB | lapatinib | 0.3188445 | 0.8877410 | 0.3188 | NA | NA |
| FBXW7 | lapatinib | 0.3216173 | 0.8877410 | 0.3216 | NA | NA |
| FGFR3 | lapatinib | 0.3229794 | 0.8877410 | 0.3230 | NA | NA |
| PAX5 | lapatinib | 0.3307420 | 0.8877410 | 0.3307 | NA | NA |
| TSC2 | lapatinib | 0.3311360 | 0.8877410 | 0.3311 | NA | NA |
| AKT3 | lapatinib | 0.3649345 | 0.8877410 | 0.3649 | NA | NA |
| IDH1 | lapatinib | 0.3649345 | 0.8877410 | 0.3649 | NA | NA |
| MYCN | lapatinib | 0.3649345 | 0.8877410 | 0.3649 | NA | NA |
| PDGFRB | lapatinib | 0.3673411 | 0.8877410 | 0.3673 | NA | NA |
| TSC1 | lapatinib | 0.3673411 | 0.8877410 | 0.3673 | NA | NA |
| TSC1 | sunitinib | 0.0300384 | 0.8879684 | 0.030 |
|
NA |
| SF3B1 | sunitinib | 0.0358665 | 0.8879684 | 0.036 |
|
NA |
| CREBBP | sunitinib | 0.0413703 | 0.8879684 | 0.041 |
|
NA |
| CDK6 | sunitinib | 0.0453261 | 0.8879684 | 0.045 |
|
NA |
| DNMT3A | sunitinib | 0.0480660 | 0.8879684 | 0.048 |
|
NA |
| RET | sunitinib | 0.0511239 | 0.8879684 | 0.051 | NA | NA |
| KMT2A | sunitinib | 0.0567409 | 0.8879684 | 0.057 | NA | NA |
| STAG2 | sunitinib | 0.0614276 | 0.8879684 | 0.061 | NA | NA |
| RPL10 | sunitinib | 0.0880602 | 0.8879684 | 0.088 | NA | NA |
| WT1 | sunitinib | 0.0903271 | 0.8879684 | 0.090 | NA | NA |
| PAX5 | sunitinib | 0.1124728 | 0.8879684 | 0.112 | NA | NA |
| FLCN | sunitinib | 0.1281801 | 0.8879684 | 0.128 | NA | NA |
| CBL | sunitinib | 0.1283819 | 0.8879684 | 0.128 | NA | NA |
| CDK4 | sunitinib | 0.1393853 | 0.8879684 | 0.139 | NA | NA |
| DNAJB1 | sunitinib | 0.1441839 | 0.8879684 | 0.144 | NA | NA |
| RUNX1 | sunitinib | 0.1467646 | 0.8879684 | 0.147 | NA | NA |
| RIT1 | sunitinib | 0.1606843 | 0.8879684 | 0.161 | NA | NA |
| SMC1A | sunitinib | 0.1610595 | 0.8879684 | 0.161 | NA | NA |
| GATA2 | sunitinib | 0.1728009 | 0.8879684 | 0.173 | NA | NA |
| SETBP1 | sunitinib | 0.1847349 | 0.8879684 | 0.185 | NA | NA |
| ALK | sunitinib | 0.1882759 | 0.8879684 | 0.188 | NA | NA |
| TSC2 | sunitinib | 0.1886391 | 0.8879684 | 0.189 | NA | NA |
| NT5C2 | sunitinib | 0.2060779 | 0.8879684 | 0.206 | NA | NA |
| PTEN | sunitinib | 0.2301212 | 0.8879684 | 0.230 | NA | NA |
| ATM | sunitinib | 0.2338151 | 0.8879684 | 0.234 | NA | NA |
| GATA3 | sunitinib | 0.2349335 | 0.8879684 | 0.235 | NA | NA |
| GNAS | sunitinib | 0.2380488 | 0.8879684 | 0.238 | NA | NA |
| PML | sunitinib | 0.2560406 | 0.8879684 | 0.256 | NA | NA |
| STAT3 | sunitinib | 0.2711355 | 0.8879684 | 0.271 | NA | NA |
| CXCR4 | sunitinib | 0.2869137 | 0.8879684 | 0.287 | NA | NA |
| ZRSR2 | sunitinib | 0.2895406 | 0.8879684 | 0.290 | NA | NA |
| GNB1 | sunitinib | 0.2903826 | 0.8879684 | 0.290 | NA | NA |
| EML4 | sunitinib | 0.2909234 | 0.8879684 | 0.291 | NA | NA |
| CD79B | sunitinib | 0.2950346 | 0.8879684 | 0.295 | NA | NA |
| GNAQ | sunitinib | 0.2950346 | 0.8879684 | 0.295 | NA | NA |
| BTK | sunitinib | 0.3113123 | 0.8879684 | 0.311 | NA | NA |
| GATA1 | sunitinib | 0.3154704 | 0.8879684 | 0.315 | NA | NA |
| MET | sunitinib | 0.3589333 | 0.8879684 | 0.359 | NA | NA |
| MDM2 | sunitinib | 0.3616422 | 0.8879684 | 0.362 | NA | NA |
| XPO1 | sunitinib | 0.3697335 | 0.8879684 | 0.370 | NA | NA |
| AKT3 | sunitinib | 0.3829361 | 0.8879684 | 0.383 | NA | NA |
| RAD21 | sunitinib | 0.3873632 | 0.8879684 | 0.387 | NA | NA |
| BCORL1 | sunitinib | 0.3905032 | 0.8879684 | 0.391 | NA | NA |
| FGFR1 | sunitinib | 0.3924162 | 0.8879684 | 0.392 | NA | NA |
| UGT1A1 | sunitinib | 0.3992388 | 0.8879684 | 0.399 | NA | NA |
| PIK3CA | sunitinib | 0.4133331 | 0.8879684 | 0.413 | NA | NA |
| AR | sunitinib | 0.4370527 | 0.8879684 | 0.437 | NA | NA |
| IKZF1 | sunitinib | 0.4601764 | 0.8879684 | 0.460 | NA | NA |
| JAK1 | sunitinib | 0.4658224 | 0.8879684 | 0.466 | NA | NA |
| PTCH1 | sunitinib | 0.4664159 | 0.8879684 | 0.466 | NA | NA |
| SMC3 | sunitinib | 0.4719892 | 0.8879684 | 0.472 | NA | NA |
| MPL | sunitinib | 0.4753748 | 0.8879684 | 0.475 | NA | NA |
| PDCD1 | sunitinib | 0.4810096 | 0.8879684 | 0.481 | NA | NA |
| CALR | sunitinib | 0.4811019 | 0.8879684 | 0.481 | NA | NA |
| ERBB2 | sunitinib | 0.4842706 | 0.8879684 | 0.484 | NA | NA |
| PDGFRA | sunitinib | 0.4989956 | 0.8879684 | 0.499 | NA | NA |
| WHSC1 | sunitinib | 0.5013812 | 0.8879684 | 0.501 | NA | NA |
| PHF6 | sunitinib | 0.5059450 | 0.8879684 | 0.506 | NA | NA |
| PDGFRB | sunitinib | 0.5106193 | 0.8879684 | 0.511 | NA | NA |
| SF1 | sunitinib | 0.5144054 | 0.8879684 | 0.514 | NA | NA |
| JAK3 | sunitinib | 0.5153903 | 0.8879684 | 0.515 | NA | NA |
| CYP19A1 | sunitinib | 0.5166344 | 0.8879684 | 0.517 | NA | NA |
| BRAF | sunitinib | 0.5308225 | 0.8879684 | 0.531 | NA | NA |
| ESR1 | sunitinib | 0.5643768 | 0.8879684 | 0.564 | NA | NA |
| FLT3 | sunitinib | 0.5660424 | 0.8879684 | 0.566 | NA | NA |
| PDGFB | sunitinib | 0.5660424 | 0.8879684 | 0.566 | NA | NA |
| NRAS | sunitinib | 0.5749041 | 0.8879684 | 0.575 | NA | NA |
| ABL1 | sunitinib | 0.5802023 | 0.8879684 | 0.580 | NA | NA |
| FGFR3 | sunitinib | 0.5938828 | 0.8879684 | 0.594 | NA | NA |
| PRPF40B | sunitinib | 0.5980324 | 0.8879684 | 0.598 | NA | NA |
| IDH2 | sunitinib | 0.6010327 | 0.8879684 | 0.601 | NA | NA |
| VHL | sunitinib | 0.6024171 | 0.8879684 | 0.602 | NA | NA |
| CTNNB1 | sunitinib | 0.6030844 | 0.8879684 | 0.603 | NA | NA |
| SETD2 | sunitinib | 0.6036916 | 0.8879684 | 0.604 | NA | NA |
| ROS1 | sunitinib | 0.6060667 | 0.8879684 | 0.606 | NA | NA |
| CSF3R | sunitinib | 0.6077091 | 0.8879684 | 0.608 | NA | NA |
| BCOR | sunitinib | 0.6110543 | 0.8879684 | 0.611 | NA | NA |
| NOTCH1 | sunitinib | 0.6162376 | 0.8879684 | 0.616 | NA | NA |
| AKT2 | sunitinib | 0.6176121 | 0.8879684 | 0.618 | NA | NA |
| G6PD | sunitinib | 0.6213525 | 0.8879684 | 0.621 | NA | NA |
| PIGA | sunitinib | 0.6213525 | 0.8879684 | 0.621 | NA | NA |
| EGFR | sunitinib | 0.6347395 | 0.8879684 | 0.635 | NA | NA |
| MGMT | sunitinib | 0.6441449 | 0.8879684 | 0.644 | NA | NA |
| PRPF8 | sunitinib | 0.6502972 | 0.8879684 | 0.650 | NA | NA |
| MAP2K1 | sunitinib | 0.6551799 | 0.8879684 | 0.655 | NA | NA |
| KIT | sunitinib | 0.6583214 | 0.8879684 | 0.658 | NA | NA |
| ATM | lapatinib | 0.3757531 | 0.8895379 | 0.3758 | NA | NA |
| GNAS | dabrafenib | 0.4837630 | 0.8916748 | 0.48376 | NA | NA |
| JAK1 | dabrafenib | 0.4940334 | 0.8916748 | 0.49403 | NA | NA |
| PDGFB | dabrafenib | 0.4964153 | 0.8916748 | 0.49642 | NA | NA |
| DDIT3 | dabrafenib | 0.4991662 | 0.8916748 | 0.49917 | NA | NA |
| ESR1 | dabrafenib | 0.5138002 | 0.8916748 | 0.51380 | NA | NA |
| FLT3 | dabrafenib | 0.5153597 | 0.8916748 | 0.51536 | NA | NA |
| PAX8 | dabrafenib | 0.5195687 | 0.8916748 | 0.51957 | NA | NA |
| RPL10 | dabrafenib | 0.5241142 | 0.8916748 | 0.52411 | NA | NA |
| ROS1 | midostaurin | 0.5814725 | 0.8921766 | 0.5815 | NA | NA |
| CDK4 | midostaurin | 0.5892242 | 0.8921766 | 0.5892 | NA | NA |
| MYCN | midostaurin | 0.5948521 | 0.8921766 | 0.5949 | NA | NA |
| GATA3 | midostaurin | 0.5993247 | 0.8921766 | 0.5993 | NA | NA |
| PAX8 | afatinib | 0.4284981 | 0.8922369 | 0.4285 | NA | NA |
| PDCD1 | afatinib | 0.4342385 | 0.8922369 | 0.4342 | NA | NA |
| RET | afatinib | 0.4515995 | 0.8922369 | 0.4516 | NA | NA |
| EGFR | afatinib | 0.4594260 | 0.8922369 | 0.4594 | NA | NA |
| SMC1A | afatinib | 0.4735125 | 0.8922369 | 0.4735 | NA | NA |
| CREBBP | afatinib | 0.4804225 | 0.8922369 | 0.4804 | NA | NA |
| PRPF40B | afatinib | 0.4830174 | 0.8922369 | 0.4830 | NA | NA |
| CTCF | afatinib | 0.4847708 | 0.8922369 | 0.4848 | NA | NA |
| AKT3 | afatinib | 0.4858445 | 0.8922369 | 0.4858 | NA | NA |
| PDGFRB | afatinib | 0.4872986 | 0.8922369 | 0.4873 | NA | NA |
| SMO | cabozantinib | 0.6697490 | 0.8933197 | 0.6697 | NA | NA |
| XPO1 | cabozantinib | 0.6741548 | 0.8933197 | 0.6742 | NA | NA |
| IKZF1 | cabozantinib | 0.6895685 | 0.8933197 | 0.6896 | NA | NA |
| PML | cabozantinib | 0.6926459 | 0.8933197 | 0.6926 | NA | NA |
| PDGFB | cabozantinib | 0.6931930 | 0.8933197 | 0.6932 | NA | NA |
| CDKN2A | cabozantinib | 0.6975307 | 0.8933197 | 0.6975 | NA | NA |
| IL7R | cabozantinib | 0.7075726 | 0.8933197 | 0.7076 | NA | NA |
| PRPF40B | cabozantinib | 0.7092004 | 0.8933197 | 0.7092 | NA | NA |
| GATA2 | docetaxel | 0.6066753 | 0.8934136 | 0.60668 | NA | NA |
| BRCA2 | docetaxel | 0.6116514 | 0.8934136 | 0.61165 | NA | NA |
| EML4 | docetaxel | 0.6185171 | 0.8934136 | 0.61852 | NA | NA |
| ESR1 | cabozantinib | 0.7161231 | 0.8934488 | 0.7161 | NA | NA |
| PDGFRB | alectinib | 0.6381495 | 0.8942058 | 0.6381 | NA | NA |
| RUNX1 | alectinib | 0.6416439 | 0.8942058 | 0.6416 | NA | NA |
| NT5C2 | gefitinib | 0.5963461 | 0.8942114 | 0.5963 | NA | NA |
| PTEN | gefitinib | 0.5969493 | 0.8942114 | 0.5969 | NA | NA |
| GATA2 | gefitinib | 0.6160722 | 0.8942114 | 0.6161 | NA | NA |
| DDIT3 | gefitinib | 0.6170733 | 0.8942114 | 0.6171 | NA | NA |
| ETV6 | gefitinib | 0.6204801 | 0.8942114 | 0.6205 | NA | NA |
| KRAS | gefitinib | 0.6235545 | 0.8942114 | 0.6236 | NA | NA |
| SMC3 | gefitinib | 0.6263365 | 0.8942114 | 0.6263 | NA | NA |
| FANCL | gefitinib | 0.6370118 | 0.8942114 | 0.6370 | NA | NA |
| UGT1A1 | gefitinib | 0.6466857 | 0.8942114 | 0.6467 | NA | NA |
| CBLB | gefitinib | 0.6512627 | 0.8942114 | 0.6513 | NA | NA |
| TSC2 | gefitinib | 0.6534622 | 0.8942114 | 0.6535 | NA | NA |
| IDH2 | crizotinib | 0.4011464 | 0.8948650 | 0.4011 | NA | NA |
| ALK | tretinoin | 0.7717427 | 0.8957728 | 0.7717 | NA | NA |
| RUNX1 | dabrafenib | 0.5389208 | 0.8964207 | 0.53892 | NA | NA |
| PTCH1 | dabrafenib | 0.5410696 | 0.8964207 | 0.54107 | NA | NA |
| UGT1A1 | dabrafenib | 0.5474325 | 0.8964207 | 0.54743 | NA | NA |
| UGT1A1 | alectinib | 0.6542466 | 0.8965374 | 0.6542 | NA | NA |
| NOTCH2 | alectinib | 0.6570045 | 0.8965374 | 0.6570 | NA | NA |
| ABL1 | nilotinib | 0.7313136 | 0.8968941 | 0.7313 | NA | NA |
| PHF6 | lapatinib | 0.3938211 | 0.8970094 | 0.3938 | NA | NA |
| PDCD1 | lapatinib | 0.4012535 | 0.8970094 | 0.4013 | NA | NA |
| SETD2 | lapatinib | 0.4021077 | 0.8970094 | 0.4021 | NA | NA |
| PTPN11 | belinostat | 0.0156755 | 0.8970712 | 0.01568 |
|
NA |
| TP53 | belinostat | 0.0391583 | 0.8970712 | 0.03916 |
|
NA |
| NRAS | belinostat | 0.0419064 | 0.8970712 | 0.04191 |
|
NA |
| SETBP1 | belinostat | 0.0619635 | 0.8970712 | 0.06196 | NA | NA |
| TPMT | belinostat | 0.0656977 | 0.8970712 | 0.06570 | NA | NA |
| PDGFRB | belinostat | 0.0666829 | 0.8970712 | 0.06668 | NA | NA |
| BRAF | belinostat | 0.0744959 | 0.8970712 | 0.07450 | NA | NA |
| DNAJB1 | belinostat | 0.0814309 | 0.8970712 | 0.08143 | NA | NA |
| BCOR | belinostat | 0.0836126 | 0.8970712 | 0.08361 | NA | NA |
| STAG2 | belinostat | 0.0851654 | 0.8970712 | 0.08517 | NA | NA |
| CD274 | belinostat | 0.0932739 | 0.8970712 | 0.09327 | NA | NA |
| BCORL1 | belinostat | 0.1094027 | 0.8970712 | 0.10940 | NA | NA |
| NCOA2 | belinostat | 0.1222655 | 0.8970712 | 0.12227 | NA | NA |
| IDH2 | belinostat | 0.1232427 | 0.8970712 | 0.12324 | NA | NA |
| MAP2K2 | belinostat | 0.1254344 | 0.8970712 | 0.12543 | NA | NA |
| VHL | belinostat | 0.1257218 | 0.8970712 | 0.12572 | NA | NA |
| KMT2A | belinostat | 0.1296916 | 0.8970712 | 0.12969 | NA | NA |
| MET | belinostat | 0.1348014 | 0.8970712 | 0.13480 | NA | NA |
| CBL | belinostat | 0.1450619 | 0.8970712 | 0.14506 | NA | NA |
| NPM1 | belinostat | 0.1498150 | 0.8970712 | 0.14982 | NA | NA |
| SF1 | belinostat | 0.1506532 | 0.8970712 | 0.15065 | NA | NA |
| DPYD | tretinoin | 0.7806169 | 0.8973864 | 0.7806 | NA | NA |
| CXCR4 | tretinoin | 0.7873492 | 0.8973864 | 0.7873 | NA | NA |
| CDKN2A | tretinoin | 0.8022030 | 0.8973864 | 0.8022 | NA | NA |
| FLCN | tretinoin | 0.8043691 | 0.8973864 | 0.8044 | NA | NA |
| FLT3 | tretinoin | 0.8076478 | 0.8973864 | 0.8076 | NA | NA |
| U2AF1 | afatinib | 0.4972408 | 0.8977958 | 0.4972 | NA | NA |
| JAK1 | gefitinib | 0.6632200 | 0.8981105 | 0.6632 | NA | NA |
| FLCN | nilotinib | 0.7393663 | 0.8982955 | 0.7394 | NA | NA |
| SF3B1 | ruxolitinib | 0.6933953 | 0.8993543 | 0.6934 | NA | NA |
| PTPN11 | tretinoin | 0.8170201 | 0.9001069 | 0.8170 | NA | NA |
| SETBP1 | erlotinib | 0.7514881 | 0.9002202 | 0.7515 | NA | NA |
| NOTCH1 | tretinoin | 0.8264829 | 0.9005863 | 0.8265 | NA | NA |
| MGMT | tretinoin | 0.8349168 | 0.9005863 | 0.8349 | NA | NA |
| SMC1A | tretinoin | 0.8382380 | 0.9005863 | 0.8382 | NA | NA |
| TET2 | ponatinib | 0.1895014 | 0.9011644 | 0.190 | NA | NA |
| ATM | ponatinib | 0.1926153 | 0.9011644 | 0.193 | NA | NA |
| NT5C2 | midostaurin | 0.6123593 | 0.9013378 | 0.6124 | NA | NA |
| FGFR3 | crizotinib | 0.4127192 | 0.9033100 | 0.4127 | NA | NA |
| KIT | dasatinib | 0.7398951 | 0.9034509 | 0.740 | NA | NA |
| RET | lapatinib | 0.4130391 | 0.9040101 | 0.4130 | NA | NA |
| IDH1 | midostaurin | 0.6274123 | 0.9046468 | 0.6274 | NA | NA |
| ZRSR2 | midostaurin | 0.6464003 | 0.9046468 | 0.6464 | NA | NA |
| EZH2 | midostaurin | 0.6468498 | 0.9046468 | 0.6468 | NA | NA |
| FLT3 | midostaurin | 0.6526579 | 0.9046468 | 0.6527 | NA | NA |
| CTLA4 | midostaurin | 0.6682026 | 0.9046468 | 0.6682 | NA | NA |
| U2AF1 | midostaurin | 0.6708859 | 0.9046468 | 0.6709 | NA | NA |
| HRAS | midostaurin | 0.6727624 | 0.9046468 | 0.6728 | NA | NA |
| SF1 | midostaurin | 0.6811779 | 0.9046468 | 0.6812 | NA | NA |
| ESR1 | midostaurin | 0.6835330 | 0.9046468 | 0.6835 | NA | NA |
| EML4 | midostaurin | 0.6914164 | 0.9046468 | 0.6914 | NA | NA |
| ETV6 | midostaurin | 0.7039964 | 0.9046468 | 0.7040 | NA | NA |
| NOTCH1 | midostaurin | 0.7089128 | 0.9046468 | 0.7089 | NA | NA |
| BTK | midostaurin | 0.7129549 | 0.9046468 | 0.7130 | NA | NA |
| ERBB4 | midostaurin | 0.7168444 | 0.9046468 | 0.7168 | NA | NA |
| EED | midostaurin | 0.7259376 | 0.9046468 | 0.7259 | NA | NA |
| PAX5 | midostaurin | 0.7382339 | 0.9046468 | 0.7382 | NA | NA |
| TPMT | midostaurin | 0.7460273 | 0.9046468 | 0.7460 | NA | NA |
| PDCD1 | midostaurin | 0.7514117 | 0.9046468 | 0.7514 | NA | NA |
| CDC73 | midostaurin | 0.7520422 | 0.9046468 | 0.7520 | NA | NA |
| FANCL | midostaurin | 0.7611087 | 0.9046468 | 0.7611 | NA | NA |
| SETBP1 | midostaurin | 0.7737089 | 0.9046468 | 0.7737 | NA | NA |
| KMT2A | midostaurin | 0.7807486 | 0.9046468 | 0.7807 | NA | NA |
| RAD21 | midostaurin | 0.7818238 | 0.9046468 | 0.7818 | NA | NA |
| RUNX1 | midostaurin | 0.7821353 | 0.9046468 | 0.7821 | NA | NA |
| ASXL1 | midostaurin | 0.7907471 | 0.9046468 | 0.7907 | NA | NA |
| BRAF | midostaurin | 0.7943467 | 0.9046468 | 0.7943 | NA | NA |
| PHF6 | midostaurin | 0.8168214 | 0.9046468 | 0.8168 | NA | NA |
| CD79B | midostaurin | 0.8277512 | 0.9046468 | 0.8278 | NA | NA |
| G6PD | midostaurin | 0.8281741 | 0.9046468 | 0.8282 | NA | NA |
| WHSC1 | midostaurin | 0.8326953 | 0.9046468 | 0.8327 | NA | NA |
| GATA2 | midostaurin | 0.8338411 | 0.9046468 | 0.8338 | NA | NA |
| MET | midostaurin | 0.8355898 | 0.9046468 | 0.8356 | NA | NA |
| CYP19A1 | afatinib | 0.5081199 | 0.9048710 | 0.5081 | NA | NA |
| PML | gefitinib | 0.6752846 | 0.9050206 | 0.6753 | NA | NA |
| CDKN2A | sunitinib | 0.6799349 | 0.9053535 | 0.680 | NA | NA |
| EZH2 | sunitinib | 0.6938567 | 0.9053535 | 0.694 | NA | NA |
| NOTCH2 | sunitinib | 0.7032998 | 0.9053535 | 0.703 | NA | NA |
| FBXW7 | sunitinib | 0.7083621 | 0.9053535 | 0.708 | NA | NA |
| SMO | sunitinib | 0.7239446 | 0.9053535 | 0.724 | NA | NA |
| FANCL | sunitinib | 0.7369648 | 0.9053535 | 0.737 | NA | NA |
| EGF | sunitinib | 0.7398358 | 0.9053535 | 0.740 | NA | NA |
| IL7R | sunitinib | 0.7398358 | 0.9053535 | 0.740 | NA | NA |
| DPYD | sunitinib | 0.7414533 | 0.9053535 | 0.741 | NA | NA |
| FGFR2 | palbociclib | 0.6430949 | 0.9063294 | 0.6431 | NA | NA |
| SH2B3 | palbociclib | 0.6434247 | 0.9063294 | 0.6434 | NA | NA |
| ASXL1 | temozolomide | 0.7680740 | 0.9064658 | 0.76807 | NA | NA |
| ETV6 | vismodegib | 0.0097525 | 0.9068778 | 0.0098 | ** | NA |
| XPO1 | vismodegib | 0.0197148 | 0.9068778 | 0.0197 |
|
NA |
| GNAQ | vismodegib | 0.0250242 | 0.9068778 | 0.0250 |
|
NA |
| CDC73 | vismodegib | 0.0366254 | 0.9068778 | 0.0366 |
|
NA |
| EZH2 | vismodegib | 0.0623528 | 0.9068778 | 0.0624 | NA | NA |
| ZRSR2 | vismodegib | 0.0682009 | 0.9068778 | 0.0682 | NA | NA |
| CDK4 | vismodegib | 0.0707615 | 0.9068778 | 0.0708 | NA | NA |
| RUNX1 | vismodegib | 0.0874842 | 0.9068778 | 0.0875 | NA | NA |
| RPL10 | vismodegib | 0.0892587 | 0.9068778 | 0.0893 | NA | NA |
| NCOA2 | vismodegib | 0.0893861 | 0.9068778 | 0.0894 | NA | NA |
| SH2B3 | vismodegib | 0.0934678 | 0.9068778 | 0.0935 | NA | NA |
| TET2 | vismodegib | 0.0981762 | 0.9068778 | 0.0982 | NA | NA |
| CTLA4 | vismodegib | 0.1069540 | 0.9068778 | 0.1070 | NA | NA |
| FANCL | vismodegib | 0.1143467 | 0.9068778 | 0.1143 | NA | NA |
| STAT3 | vismodegib | 0.1166536 | 0.9068778 | 0.1167 | NA | NA |
| JAK2 | vismodegib | 0.1385135 | 0.9068778 | 0.1385 | NA | NA |
| RAD21 | vismodegib | 0.1386885 | 0.9068778 | 0.1387 | NA | NA |
| WHSC1 | vismodegib | 0.1543822 | 0.9068778 | 0.1544 | NA | NA |
| MAP2K1 | vismodegib | 0.1617145 | 0.9068778 | 0.1617 | NA | NA |
| BRAF | vismodegib | 0.1624273 | 0.9068778 | 0.1624 | NA | NA |
| GNA11 | vismodegib | 0.1941667 | 0.9068778 | 0.1942 | NA | NA |
| VHL | vismodegib | 0.1982659 | 0.9068778 | 0.1983 | NA | NA |
| IDH2 | vismodegib | 0.2041835 | 0.9068778 | 0.2042 | NA | NA |
| EML4 | vismodegib | 0.2074836 | 0.9068778 | 0.2075 | NA | NA |
| SRSF2 | vismodegib | 0.2103014 | 0.9068778 | 0.2103 | NA | NA |
| BRCA1 | vismodegib | 0.2203270 | 0.9068778 | 0.2203 | NA | NA |
| PDGFB | vismodegib | 0.2233811 | 0.9068778 | 0.2234 | NA | NA |
| NOTCH1 | vismodegib | 0.2273665 | 0.9068778 | 0.2274 | NA | NA |
| KIT | vismodegib | 0.2326739 | 0.9068778 | 0.2327 | NA | NA |
| SF3B1 | vismodegib | 0.2348374 | 0.9068778 | 0.2348 | NA | NA |
| SMC3 | vismodegib | 0.2452829 | 0.9068778 | 0.2453 | NA | NA |
| G6PD | vismodegib | 0.2460143 | 0.9068778 | 0.2460 | NA | NA |
| TSC1 | vismodegib | 0.2476631 | 0.9068778 | 0.2477 | NA | NA |
| JAK1 | vismodegib | 0.2513278 | 0.9068778 | 0.2513 | NA | NA |
| MAP2K2 | vismodegib | 0.2563401 | 0.9068778 | 0.2563 | NA | NA |
| CEBPA | vismodegib | 0.2638745 | 0.9068778 | 0.2639 | NA | NA |
| TPMT | vismodegib | 0.2650075 | 0.9068778 | 0.2650 | NA | NA |
| SETD2 | vismodegib | 0.2650874 | 0.9068778 | 0.2651 | NA | NA |
| TSC2 | ponatinib | 0.2051961 | 0.9073297 | 0.205 | NA | NA |
| JAK1 | ponatinib | 0.2077854 | 0.9073297 | 0.208 | NA | NA |
| CALR | gefitinib | 0.6884355 | 0.9074800 | 0.6884 | NA | NA |
| CSF3R | gefitinib | 0.6946468 | 0.9074800 | 0.6946 | NA | NA |
| FGFR2 | gefitinib | 0.6980616 | 0.9074800 | 0.6981 | NA | NA |
| CD274 | trametinib | 0.5701244 | 0.9080774 | 0.57012 | NA | NA |
| TPMT | trametinib | 0.6050220 | 0.9080774 | 0.60502 | NA | NA |
| ATM | trametinib | 0.6061888 | 0.9080774 | 0.60619 | NA | NA |
| GNA11 | trametinib | 0.6063817 | 0.9080774 | 0.60638 | NA | NA |
| EED | trametinib | 0.6074766 | 0.9080774 | 0.60748 | NA | NA |
| FLCN | trametinib | 0.6190484 | 0.9080774 | 0.61905 | NA | NA |
| AKT1 | trametinib | 0.6346674 | 0.9080774 | 0.63467 | NA | NA |
| CD79B | trametinib | 0.6446579 | 0.9080774 | 0.64466 | NA | NA |
| PTPN11 | trametinib | 0.6470969 | 0.9080774 | 0.64710 | NA | NA |
| SF1 | trametinib | 0.6556570 | 0.9080774 | 0.65566 | NA | NA |
| STAG2 | trametinib | 0.6561590 | 0.9080774 | 0.65616 | NA | NA |
| MPL | trametinib | 0.6589843 | 0.9080774 | 0.65898 | NA | NA |
| TET2 | trametinib | 0.6734045 | 0.9080774 | 0.67340 | NA | NA |
| EML4 | trametinib | 0.6775722 | 0.9080774 | 0.67757 | NA | NA |
| JAK1 | trametinib | 0.6886991 | 0.9080774 | 0.68870 | NA | NA |
| ESR1 | trametinib | 0.6962680 | 0.9080774 | 0.69627 | NA | NA |
| SMC3 | trametinib | 0.6972222 | 0.9080774 | 0.69722 | NA | NA |
| SMC1A | trametinib | 0.7004160 | 0.9080774 | 0.70042 | NA | NA |
| EZH2 | trametinib | 0.7036019 | 0.9080774 | 0.70360 | NA | NA |
| SRSF2 | trametinib | 0.7053488 | 0.9080774 | 0.70535 | NA | NA |
| CBL | trametinib | 0.7179539 | 0.9080774 | 0.71795 | NA | NA |
| CRLF2 | trametinib | 0.7189639 | 0.9080774 | 0.71896 | NA | NA |
| EGFR | trametinib | 0.7194767 | 0.9080774 | 0.71948 | NA | NA |
| AKT1 | vismodegib | 0.2724738 | 0.9082459 | 0.2725 | NA | NA |
| ASXL1 | crizotinib | 0.4390544 | 0.9089778 | 0.4391 | NA | NA |
| ESR1 | crizotinib | 0.4487601 | 0.9089778 | 0.4488 | NA | NA |
| STAT3 | crizotinib | 0.4489323 | 0.9089778 | 0.4489 | NA | NA |
| U2AF1 | crizotinib | 0.4627036 | 0.9089778 | 0.4627 | NA | NA |
| SMO | crizotinib | 0.4736088 | 0.9089778 | 0.4736 | NA | NA |
| CRLF2 | crizotinib | 0.4795458 | 0.9089778 | 0.4795 | NA | NA |
| GNAS | crizotinib | 0.4890065 | 0.9089778 | 0.4890 | NA | NA |
| RET | crizotinib | 0.5041789 | 0.9089778 | 0.5042 | NA | NA |
| FGFR1 | crizotinib | 0.5187132 | 0.9089778 | 0.5187 | NA | NA |
| SF1 | crizotinib | 0.5238314 | 0.9089778 | 0.5238 | NA | NA |
| AKT3 | crizotinib | 0.5260488 | 0.9089778 | 0.5260 | NA | NA |
| ABL1 | crizotinib | 0.5320626 | 0.9089778 | 0.5321 | NA | NA |
| BCORL1 | crizotinib | 0.5399529 | 0.9089778 | 0.5400 | NA | NA |
| MGMT | crizotinib | 0.5501355 | 0.9089778 | 0.5501 | NA | NA |
| JAK2 | crizotinib | 0.5623793 | 0.9089778 | 0.5624 | NA | NA |
| TET2 | crizotinib | 0.5676235 | 0.9089778 | 0.5676 | NA | NA |
| PAX8 | crizotinib | 0.5685501 | 0.9089778 | 0.5686 | NA | NA |
| IL7R | crizotinib | 0.5731295 | 0.9089778 | 0.5731 | NA | NA |
| WT1 | crizotinib | 0.5747532 | 0.9089778 | 0.5748 | NA | NA |
| KMT2A | crizotinib | 0.5794379 | 0.9089778 | 0.5794 | NA | NA |
| PIK3CA | crizotinib | 0.5887265 | 0.9089778 | 0.5887 | NA | NA |
| GATA2 | crizotinib | 0.5930452 | 0.9089778 | 0.5930 | NA | NA |
| BRAF | crizotinib | 0.6026642 | 0.9089778 | 0.6027 | NA | NA |
| CALR | crizotinib | 0.6126271 | 0.9089778 | 0.6126 | NA | NA |
| ETV6 | crizotinib | 0.6144403 | 0.9089778 | 0.6144 | NA | NA |
| CYP19A1 | crizotinib | 0.6190452 | 0.9089778 | 0.6190 | NA | NA |
| CD274 | gefitinib | 0.7222314 | 0.9100743 | 0.7222 | NA | NA |
| MAP2K1 | gefitinib | 0.7231455 | 0.9100743 | 0.7231 | NA | NA |
| RUNX1 | gefitinib | 0.7245837 | 0.9100743 | 0.7246 | NA | NA |
| GNAQ | gefitinib | 0.7280594 | 0.9100743 | 0.7281 | NA | NA |
| IL7R | gefitinib | 0.7358963 | 0.9111097 | 0.7359 | NA | NA |
| PTEN | nilotinib | 0.7611038 | 0.9112606 | 0.7611 | NA | NA |
| CSF3R | nilotinib | 0.7665100 | 0.9112606 | 0.7665 | NA | NA |
| PML | nilotinib | 0.7777017 | 0.9112606 | 0.7777 | NA | NA |
| CD79B | nilotinib | 0.7872284 | 0.9112606 | 0.7872 | NA | NA |
| AKT2 | nilotinib | 0.7949272 | 0.9112606 | 0.7949 | NA | NA |
| AKT3 | nilotinib | 0.7991714 | 0.9112606 | 0.7992 | NA | NA |
| KRAS | nilotinib | 0.8058237 | 0.9112606 | 0.8058 | NA | NA |
| IDH2 | nilotinib | 0.8061151 | 0.9112606 | 0.8061 | NA | NA |
| TET2 | afatinib | 0.5315227 | 0.9118564 | 0.5315 | NA | NA |
| GNA11 | afatinib | 0.5399949 | 0.9118564 | 0.5400 | NA | NA |
| CD274 | afatinib | 0.5528302 | 0.9118564 | 0.5528 | NA | NA |
| PTPN11 | afatinib | 0.5596334 | 0.9118564 | 0.5596 | NA | NA |
| ERBB3 | afatinib | 0.5614904 | 0.9118564 | 0.5615 | NA | NA |
| SMC3 | afatinib | 0.5706429 | 0.9118564 | 0.5706 | NA | NA |
| GNB1 | afatinib | 0.5781400 | 0.9118564 | 0.5781 | NA | NA |
| CD79B | afatinib | 0.5816393 | 0.9118564 | 0.5816 | NA | NA |
| BRCA1 | afatinib | 0.5859699 | 0.9118564 | 0.5860 | NA | NA |
| STAT3 | afatinib | 0.5862188 | 0.9118564 | 0.5862 | NA | NA |
| DNAJB1 | afatinib | 0.5947756 | 0.9118564 | 0.5948 | NA | NA |
| CDK4 | afatinib | 0.6107092 | 0.9118564 | 0.6107 | NA | NA |
| JAK2 | afatinib | 0.6195384 | 0.9118564 | 0.6195 | NA | NA |
| ROS1 | afatinib | 0.6282804 | 0.9118564 | 0.6283 | NA | NA |
| TPMT | afatinib | 0.6320485 | 0.9118564 | 0.6320 | NA | NA |
| SETD2 | afatinib | 0.6344824 | 0.9118564 | 0.6345 | NA | NA |
| GATA2 | afatinib | 0.6361396 | 0.9118564 | 0.6361 | NA | NA |
| IL7R | afatinib | 0.6415553 | 0.9118564 | 0.6416 | NA | NA |
| MYCN | afatinib | 0.6464575 | 0.9118564 | 0.6465 | NA | NA |
| PTEN | afatinib | 0.6523280 | 0.9118564 | 0.6523 | NA | NA |
| WHSC1 | gefitinib | 0.7582570 | 0.9123047 | 0.7583 | NA | NA |
| AKT1 | gefitinib | 0.7625117 | 0.9123047 | 0.7625 | NA | NA |
| CTNNB1 | gefitinib | 0.7648316 | 0.9123047 | 0.7648 | NA | NA |
| PDGFRB | gefitinib | 0.7649324 | 0.9123047 | 0.7649 | NA | NA |
| ERBB2 | belinostat | 0.1805478 | 0.9128558 | 0.18055 | NA | NA |
| RIT1 | belinostat | 0.1819372 | 0.9128558 | 0.18194 | NA | NA |
| FGFR3 | belinostat | 0.1830783 | 0.9128558 | 0.18308 | NA | NA |
| ABL1 | belinostat | 0.1850848 | 0.9128558 | 0.18508 | NA | NA |
| EGF | belinostat | 0.1881458 | 0.9128558 | 0.18815 | NA | NA |
| KRAS | ruxolitinib | 0.7137147 | 0.9146275 | 0.7137 | NA | NA |
| SETBP1 | ruxolitinib | 0.7191346 | 0.9146275 | 0.7191 | NA | NA |
| CBLB | dabrafenib | 0.5660789 | 0.9155103 | 0.56608 | NA | NA |
| TSC1 | cabozantinib | 0.7417760 | 0.9167232 | 0.7418 | NA | NA |
| PRPF8 | nilotinib | 0.8182825 | 0.9170407 | 0.8183 | NA | NA |
| FGFR2 | ruxolitinib | 0.7282503 | 0.9171646 | 0.7283 | NA | NA |
| PML | ruxolitinib | 0.7351319 | 0.9171646 | 0.7351 | NA | NA |
| MYCN | rucaparib | 0.4390214 | 0.9173514 | 0.439 | NA | NA |
| XPO1 | rucaparib | 0.4406168 | 0.9173514 | 0.441 | NA | NA |
| ABL1 | rucaparib | 0.4411690 | 0.9173514 | 0.441 | NA | NA |
| PRPF40B | tretinoin | 0.8614099 | 0.9178958 | 0.8614 | NA | NA |
| HRAS | afatinib | 0.6742292 | 0.9182537 | 0.6742 | NA | NA |
| CALR | afatinib | 0.6938848 | 0.9182537 | 0.6939 | NA | NA |
| SSX1 | afatinib | 0.6952155 | 0.9182537 | 0.6952 | NA | NA |
| KMT2A | afatinib | 0.7030506 | 0.9182537 | 0.7031 | NA | NA |
| GNAS | afatinib | 0.7054184 | 0.9182537 | 0.7054 | NA | NA |
| WT1 | afatinib | 0.7062470 | 0.9182537 | 0.7062 | NA | NA |
| CSF3R | afatinib | 0.7063490 | 0.9182537 | 0.7063 | NA | NA |
| IL7R | palbociclib | 0.6625578 | 0.9184461 | 0.6626 | NA | NA |
| MYD88 | palbociclib | 0.6675616 | 0.9184461 | 0.6676 | NA | NA |
| MAP2K1 | palbociclib | 0.6736365 | 0.9184461 | 0.6736 | NA | NA |
| BRCA1 | palbociclib | 0.6850052 | 0.9184461 | 0.6850 | NA | NA |
| PRPF8 | palbociclib | 0.6959597 | 0.9184461 | 0.6960 | NA | NA |
| TET2 | palbociclib | 0.7041197 | 0.9184461 | 0.7041 | NA | NA |
| FLCN | palbociclib | 0.7051976 | 0.9184461 | 0.7052 | NA | NA |
| ERBB2 | palbociclib | 0.7083268 | 0.9184461 | 0.7083 | NA | NA |
| MYCN | palbociclib | 0.7218549 | 0.9184461 | 0.7219 | NA | NA |
| CD274 | palbociclib | 0.7221370 | 0.9184461 | 0.7221 | NA | NA |
| PDGFRB | palbociclib | 0.7303977 | 0.9200202 | 0.7304 | NA | NA |
| ALK | docetaxel | 0.6482988 | 0.9200790 | 0.64830 | NA | NA |
| SMC1A | docetaxel | 0.6559586 | 0.9200790 | 0.65596 | NA | NA |
| FLCN | docetaxel | 0.6632639 | 0.9200790 | 0.66326 | NA | NA |
| PIGA | docetaxel | 0.6672514 | 0.9200790 | 0.66725 | NA | NA |
| FLT3 | docetaxel | 0.6723654 | 0.9200790 | 0.67237 | NA | NA |
| BTK | cabozantinib | 0.7515825 | 0.9201618 | 0.7516 | NA | NA |
| CXCR4 | cabozantinib | 0.7645614 | 0.9202001 | 0.7646 | NA | NA |
| WT1 | cabozantinib | 0.7656627 | 0.9202001 | 0.7657 | NA | NA |
| IDH1 | temozolomide | 0.7871872 | 0.9207279 | 0.78719 | NA | NA |
| CDKN2A | dasatinib | 0.7625887 | 0.9214614 | 0.763 | NA | NA |
| U2AF1 | pazopanib | 0.0404444 | 0.9218585 | 0.0404 |
|
NA |
| CEBPA | pazopanib | 0.0446243 | 0.9218585 | 0.0446 |
|
NA |
| GNB1 | pazopanib | 0.0512813 | 0.9218585 | 0.0513 | NA | NA |
| NCOA2 | pazopanib | 0.0647555 | 0.9218585 | 0.0648 | NA | NA |
| NOTCH2 | pazopanib | 0.0696792 | 0.9218585 | 0.0697 | NA | NA |
| CALR | pazopanib | 0.0961360 | 0.9218585 | 0.0961 | NA | NA |
| PRPF8 | pazopanib | 0.1000832 | 0.9218585 | 0.1001 | NA | NA |
| GNA11 | pazopanib | 0.1031129 | 0.9218585 | 0.1031 | NA | NA |
| EED | pazopanib | 0.1069880 | 0.9218585 | 0.1070 | NA | NA |
| AKT3 | pazopanib | 0.1128443 | 0.9218585 | 0.1128 | NA | NA |
| ETV6 | pazopanib | 0.1180629 | 0.9218585 | 0.1181 | NA | NA |
| BTK | pazopanib | 0.1215251 | 0.9218585 | 0.1215 | NA | NA |
| FLCN | pazopanib | 0.1317962 | 0.9218585 | 0.1318 | NA | NA |
| RPL10 | pazopanib | 0.1515056 | 0.9218585 | 0.1515 | NA | NA |
| NRAS | pazopanib | 0.1573839 | 0.9218585 | 0.1574 | NA | NA |
| CREBBP | pazopanib | 0.1610486 | 0.9218585 | 0.1610 | NA | NA |
| MYCN | pazopanib | 0.1635137 | 0.9218585 | 0.1635 | NA | NA |
| FGFR2 | pazopanib | 0.1667180 | 0.9218585 | 0.1667 | NA | NA |
| PTEN | pazopanib | 0.1738665 | 0.9218585 | 0.1739 | NA | NA |
| STAG2 | pazopanib | 0.1860023 | 0.9218585 | 0.1860 | NA | NA |
| DDIT3 | pazopanib | 0.1903063 | 0.9218585 | 0.1903 | NA | NA |
| CDKN2A | pazopanib | 0.2139961 | 0.9218585 | 0.2140 | NA | NA |
| SF1 | pazopanib | 0.2189633 | 0.9218585 | 0.2190 | NA | NA |
| SSX1 | pazopanib | 0.2368944 | 0.9218585 | 0.2369 | NA | NA |
| BCORL1 | pazopanib | 0.2394178 | 0.9218585 | 0.2394 | NA | NA |
| CRLF2 | pazopanib | 0.2509570 | 0.9218585 | 0.2510 | NA | NA |
| PIGA | pazopanib | 0.2681396 | 0.9218585 | 0.2681 | NA | NA |
| TP53 | pazopanib | 0.2688657 | 0.9218585 | 0.2689 | NA | NA |
| PAX5 | pazopanib | 0.2868988 | 0.9218585 | 0.2869 | NA | NA |
| SETBP1 | pazopanib | 0.2928522 | 0.9218585 | 0.2929 | NA | NA |
| PTCH1 | pazopanib | 0.2950783 | 0.9218585 | 0.2951 | NA | NA |
| FANCL | pazopanib | 0.2951768 | 0.9218585 | 0.2952 | NA | NA |
| IDH2 | pazopanib | 0.3050404 | 0.9218585 | 0.3050 | NA | NA |
| IL7R | pazopanib | 0.3205386 | 0.9218585 | 0.3205 | NA | NA |
| MET | pazopanib | 0.3375577 | 0.9218585 | 0.3376 | NA | NA |
| ERBB2 | pazopanib | 0.3398016 | 0.9218585 | 0.3398 | NA | NA |
| RAD21 | pazopanib | 0.3462781 | 0.9218585 | 0.3463 | NA | NA |
| GATA1 | pazopanib | 0.3523703 | 0.9218585 | 0.3524 | NA | NA |
| BRAF | pazopanib | 0.3592410 | 0.9218585 | 0.3592 | NA | NA |
| BRCA2 | pazopanib | 0.3630866 | 0.9218585 | 0.3631 | NA | NA |
| TSC1 | pazopanib | 0.3683895 | 0.9218585 | 0.3684 | NA | NA |
| ATM | pazopanib | 0.3827853 | 0.9218585 | 0.3828 | NA | NA |
| DNAJB1 | pazopanib | 0.3887892 | 0.9218585 | 0.3888 | NA | NA |
| UGT1A1 | pazopanib | 0.3984406 | 0.9218585 | 0.3984 | NA | NA |
| PDCD1 | pazopanib | 0.4167317 | 0.9218585 | 0.4167 | NA | NA |
| CD274 | pazopanib | 0.4298527 | 0.9218585 | 0.4299 | NA | NA |
| JAK1 | pazopanib | 0.4308861 | 0.9218585 | 0.4309 | NA | NA |
| FLT3 | pazopanib | 0.4421181 | 0.9218585 | 0.4421 | NA | NA |
| TSC2 | pazopanib | 0.4425985 | 0.9218585 | 0.4426 | NA | NA |
| GATA2 | pazopanib | 0.4469603 | 0.9218585 | 0.4470 | NA | NA |
| MAP2K2 | pazopanib | 0.4524699 | 0.9218585 | 0.4525 | NA | NA |
| FGFR1 | pazopanib | 0.4634379 | 0.9218585 | 0.4634 | NA | NA |
| SETD2 | pazopanib | 0.4675792 | 0.9218585 | 0.4676 | NA | NA |
| PRPF40B | pazopanib | 0.4793312 | 0.9218585 | 0.4793 | NA | NA |
| G6PD | pazopanib | 0.4835225 | 0.9218585 | 0.4835 | NA | NA |
| ZRSR2 | pazopanib | 0.4840326 | 0.9218585 | 0.4840 | NA | NA |
| ASXL1 | pazopanib | 0.4847323 | 0.9218585 | 0.4847 | NA | NA |
| EGF | pazopanib | 0.4848824 | 0.9218585 | 0.4849 | NA | NA |
| EZH2 | pazopanib | 0.4934659 | 0.9218585 | 0.4935 | NA | NA |
| FBXW7 | pazopanib | 0.5019388 | 0.9218585 | 0.5019 | NA | NA |
| ERBB3 | pazopanib | 0.5092517 | 0.9218585 | 0.5093 | NA | NA |
| CDK4 | pazopanib | 0.5102304 | 0.9218585 | 0.5102 | NA | NA |
| SMC1A | pazopanib | 0.5163177 | 0.9218585 | 0.5163 | NA | NA |
| GNAQ | pazopanib | 0.5212039 | 0.9218585 | 0.5212 | NA | NA |
| WT1 | pazopanib | 0.5310459 | 0.9218585 | 0.5310 | NA | NA |
| GNAS | pazopanib | 0.5517444 | 0.9218585 | 0.5517 | NA | NA |
| CYP19A1 | pazopanib | 0.5523979 | 0.9218585 | 0.5524 | NA | NA |
| ALK | pazopanib | 0.5581192 | 0.9218585 | 0.5581 | NA | NA |
| PML | pazopanib | 0.5629739 | 0.9218585 | 0.5630 | NA | NA |
| CDC73 | pazopanib | 0.5896955 | 0.9218585 | 0.5897 | NA | NA |
| HRAS | pazopanib | 0.5941431 | 0.9218585 | 0.5941 | NA | NA |
| XPO1 | pazopanib | 0.5942691 | 0.9218585 | 0.5943 | NA | NA |
| KIT | pazopanib | 0.5948891 | 0.9218585 | 0.5949 | NA | NA |
| CSF3R | pazopanib | 0.6141144 | 0.9218585 | 0.6141 | NA | NA |
| VHL | pazopanib | 0.6176221 | 0.9218585 | 0.6176 | NA | NA |
| AKT1 | pazopanib | 0.6189835 | 0.9218585 | 0.6190 | NA | NA |
| MYD88 | pazopanib | 0.6271722 | 0.9218585 | 0.6272 | NA | NA |
| SF3B1 | pazopanib | 0.6294639 | 0.9218585 | 0.6295 | NA | NA |
| BCOR | pazopanib | 0.6547699 | 0.9218585 | 0.6548 | NA | NA |
| MDM2 | pazopanib | 0.6563096 | 0.9218585 | 0.6563 | NA | NA |
| IKZF1 | pazopanib | 0.6580499 | 0.9218585 | 0.6580 | NA | NA |
| FGFR3 | pazopanib | 0.6614324 | 0.9218585 | 0.6614 | NA | NA |
| PDGFRB | pazopanib | 0.6626651 | 0.9218585 | 0.6627 | NA | NA |
| ROS1 | pazopanib | 0.6730661 | 0.9218585 | 0.6731 | NA | NA |
| CBL | pazopanib | 0.6735525 | 0.9218585 | 0.6736 | NA | NA |
| IDH1 | pazopanib | 0.6864256 | 0.9218585 | 0.6864 | NA | NA |
| MGMT | pazopanib | 0.6911734 | 0.9218585 | 0.6912 | NA | NA |
| RUNX1 | pazopanib | 0.6915374 | 0.9218585 | 0.6915 | NA | NA |
| ESR1 | pazopanib | 0.6922709 | 0.9218585 | 0.6923 | NA | NA |
| CTLA4 | pazopanib | 0.6992202 | 0.9218585 | 0.6992 | NA | NA |
| GATA3 | pazopanib | 0.7109684 | 0.9218585 | 0.7110 | NA | NA |
| WHSC1 | pazopanib | 0.7177667 | 0.9218585 | 0.7178 | NA | NA |
| JAK3 | pazopanib | 0.7199383 | 0.9218585 | 0.7199 | NA | NA |
| SMO | pazopanib | 0.7247577 | 0.9218585 | 0.7248 | NA | NA |
| MAP2K1 | pazopanib | 0.7253435 | 0.9218585 | 0.7253 | NA | NA |
| DPYD | pazopanib | 0.7284979 | 0.9218585 | 0.7285 | NA | NA |
| SMC3 | pazopanib | 0.7292112 | 0.9218585 | 0.7292 | NA | NA |
| CBLB | pazopanib | 0.7358844 | 0.9218585 | 0.7359 | NA | NA |
| PDGFRA | pazopanib | 0.7583124 | 0.9218585 | 0.7583 | NA | NA |
| CTNNB1 | pazopanib | 0.7592589 | 0.9218585 | 0.7593 | NA | NA |
| EGFR | pazopanib | 0.7631271 | 0.9218585 | 0.7631 | NA | NA |
| CD79B | pazopanib | 0.7683275 | 0.9218585 | 0.7683 | NA | NA |
| PHF6 | pazopanib | 0.7688041 | 0.9218585 | 0.7688 | NA | NA |
| PDGFB | pazopanib | 0.7722360 | 0.9218585 | 0.7722 | NA | NA |
| NPM1 | pazopanib | 0.7880905 | 0.9218585 | 0.7881 | NA | NA |
| PAX8 | pazopanib | 0.7947477 | 0.9218585 | 0.7947 | NA | NA |
| SH2B3 | pazopanib | 0.7956485 | 0.9218585 | 0.7956 | NA | NA |
| AKT2 | pazopanib | 0.7992674 | 0.9218585 | 0.7993 | NA | NA |
| PTPN11 | pazopanib | 0.8056289 | 0.9218585 | 0.8056 | NA | NA |
| TET2 | pazopanib | 0.8164348 | 0.9218585 | 0.8164 | NA | NA |
| PIK3CA | pazopanib | 0.8224888 | 0.9218585 | 0.8225 | NA | NA |
| BRCA1 | pazopanib | 0.8251732 | 0.9218585 | 0.8252 | NA | NA |
| KMT2A | pazopanib | 0.8299580 | 0.9218585 | 0.8300 | NA | NA |
| EML4 | pazopanib | 0.8328229 | 0.9218585 | 0.8328 | NA | NA |
| RIT1 | pazopanib | 0.8336905 | 0.9218585 | 0.8337 | NA | NA |
| SRSF2 | pazopanib | 0.8374135 | 0.9218585 | 0.8374 | NA | NA |
| CREBBP | dabrafenib | 0.5825405 | 0.9226353 | 0.58254 | NA | NA |
| VHL | dabrafenib | 0.5845704 | 0.9226353 | 0.58457 | NA | NA |
| KRAS | sunitinib | 0.7642647 | 0.9226900 | 0.764 | NA | NA |
| U2AF1 | sunitinib | 0.7759414 | 0.9226900 | 0.776 | NA | NA |
| MYD88 | sunitinib | 0.7863908 | 0.9226900 | 0.786 | NA | NA |
| TP53 | sunitinib | 0.7929103 | 0.9226900 | 0.793 | NA | NA |
| JAK2 | sunitinib | 0.8046870 | 0.9226900 | 0.805 | NA | NA |
| BRCA1 | sunitinib | 0.8165800 | 0.9226900 | 0.817 | NA | NA |
| ERBB4 | sunitinib | 0.8233327 | 0.9226900 | 0.823 | NA | NA |
| NCOA2 | sunitinib | 0.8265853 | 0.9226900 | 0.827 | NA | NA |
| ERBB3 | sunitinib | 0.8272393 | 0.9226900 | 0.827 | NA | NA |
| NOTCH2 | palbociclib | 0.7431256 | 0.9230960 | 0.7431 | NA | NA |
| EGFR | palbociclib | 0.7514260 | 0.9230960 | 0.7514 | NA | NA |
| TPMT | palbociclib | 0.7668585 | 0.9230960 | 0.7669 | NA | NA |
| CYP19A1 | palbociclib | 0.7672395 | 0.9230960 | 0.7672 | NA | NA |
| GNAQ | palbociclib | 0.7733014 | 0.9230960 | 0.7733 | NA | NA |
| IKZF1 | palbociclib | 0.7792127 | 0.9230960 | 0.7792 | NA | NA |
| ETV6 | palbociclib | 0.7821653 | 0.9230960 | 0.7822 | NA | NA |
| RAD21 | docetaxel | 0.6893317 | 0.9252831 | 0.68933 | NA | NA |
| BRCA1 | docetaxel | 0.7001716 | 0.9252831 | 0.70017 | NA | NA |
| ERBB2 | docetaxel | 0.7052502 | 0.9252831 | 0.70525 | NA | NA |
| STAT3 | docetaxel | 0.7071045 | 0.9252831 | 0.70710 | NA | NA |
| STAG2 | docetaxel | 0.7117563 | 0.9252831 | 0.71176 | NA | NA |
| MAP2K1 | dabrafenib | 0.5935300 | 0.9256242 | 0.59353 | NA | NA |
| FGFR3 | tretinoin | 0.8758961 | 0.9257438 | 0.8759 | NA | NA |
| PRPF40B | crizotinib | 0.6384729 | 0.9257857 | 0.6385 | NA | NA |
| FGFR1 | tretinoin | 0.8836154 | 0.9263710 | 0.8836 | NA | NA |
| FGFR3 | imatinib | 0.6868047 | 0.9263878 | 0.687 | NA | NA |
| BRCA1 | gefitinib | 0.7929047 | 0.9271957 | 0.7929 | NA | NA |
| GATA3 | gefitinib | 0.8010561 | 0.9271957 | 0.8011 | NA | NA |
| HRAS | gefitinib | 0.8076126 | 0.9271957 | 0.8076 | NA | NA |
| U2AF1 | gefitinib | 0.8094477 | 0.9271957 | 0.8094 | NA | NA |
| XPO1 | gefitinib | 0.8161735 | 0.9271957 | 0.8162 | NA | NA |
| G6PD | gefitinib | 0.8202116 | 0.9271957 | 0.8202 | NA | NA |
| RAD21 | imatinib | 0.6963200 | 0.9284267 | 0.696 | NA | NA |
| IDH1 | sunitinib | 0.8485350 | 0.9285855 | 0.849 | NA | NA |
| MYCN | sunitinib | 0.8485350 | 0.9285855 | 0.849 | NA | NA |
| DNMT3A | gefitinib | 0.8493836 | 0.9290072 | 0.8494 | NA | NA |
| GNAS | gefitinib | 0.8530306 | 0.9290072 | 0.8530 | NA | NA |
| CRLF2 | gefitinib | 0.8566401 | 0.9290072 | 0.8566 | NA | NA |
| EML4 | gefitinib | 0.8568799 | 0.9290072 | 0.8569 | NA | NA |
| SMO | gefitinib | 0.8593636 | 0.9290072 | 0.8594 | NA | NA |
| PTPN11 | gefitinib | 0.8668680 | 0.9290072 | 0.8669 | NA | NA |
| PDCD1 | gefitinib | 0.8718376 | 0.9290072 | 0.8718 | NA | NA |
| TPMT | pazopanib | 0.8511938 | 0.9292199 | 0.8512 | NA | NA |
| SSX1 | cabozantinib | 0.7843612 | 0.9293122 | 0.7844 | NA | NA |
| NOTCH1 | cabozantinib | 0.8021819 | 0.9293122 | 0.8022 | NA | NA |
| AKT2 | cabozantinib | 0.8215110 | 0.9293122 | 0.8215 | NA | NA |
| G6PD | cabozantinib | 0.8264953 | 0.9293122 | 0.8265 | NA | NA |
| NCOA2 | cabozantinib | 0.8330328 | 0.9293122 | 0.8330 | NA | NA |
| BRCA1 | cabozantinib | 0.8333837 | 0.9293122 | 0.8334 | NA | NA |
| ETV6 | cabozantinib | 0.8369112 | 0.9293122 | 0.8369 | NA | NA |
| BRAF | cabozantinib | 0.8425783 | 0.9293122 | 0.8426 | NA | NA |
| ERBB2 | cabozantinib | 0.8477762 | 0.9293122 | 0.8478 | NA | NA |
| STAG2 | cabozantinib | 0.8502250 | 0.9293122 | 0.8502 | NA | NA |
| MET | cabozantinib | 0.8512783 | 0.9293122 | 0.8513 | NA | NA |
| MET | vismodegib | 0.2900560 | 0.9298371 | 0.2901 | NA | NA |
| GNAS | vismodegib | 0.3041539 | 0.9298371 | 0.3042 | NA | NA |
| DPYD | vismodegib | 0.3255816 | 0.9298371 | 0.3256 | NA | NA |
| RET | vismodegib | 0.3393340 | 0.9298371 | 0.3393 | NA | NA |
| CD274 | vismodegib | 0.3393363 | 0.9298371 | 0.3393 | NA | NA |
| STAG2 | vismodegib | 0.3420418 | 0.9298371 | 0.3420 | NA | NA |
| PDGFRB | vismodegib | 0.3432087 | 0.9298371 | 0.3432 | NA | NA |
| DNMT3A | vismodegib | 0.3575484 | 0.9298371 | 0.3575 | NA | NA |
| PAX5 | vismodegib | 0.3631253 | 0.9298371 | 0.3631 | NA | NA |
| BCOR | vismodegib | 0.3669291 | 0.9298371 | 0.3669 | NA | NA |
| FGFR3 | vismodegib | 0.3855608 | 0.9298371 | 0.3856 | NA | NA |
| IKZF1 | vismodegib | 0.3859382 | 0.9298371 | 0.3859 | NA | NA |
| ESR1 | vismodegib | 0.3942862 | 0.9298371 | 0.3943 | NA | NA |
| PTEN | vismodegib | 0.3964159 | 0.9298371 | 0.3964 | NA | NA |
| GATA3 | vismodegib | 0.4109497 | 0.9298371 | 0.4109 | NA | NA |
| TP53 | vismodegib | 0.4116935 | 0.9298371 | 0.4117 | NA | NA |
| RIT1 | vismodegib | 0.4144232 | 0.9298371 | 0.4144 | NA | NA |
| CBL | vismodegib | 0.4259523 | 0.9298371 | 0.4260 | NA | NA |
| NOTCH2 | vismodegib | 0.4329752 | 0.9298371 | 0.4330 | NA | NA |
| SMC1A | vismodegib | 0.4388743 | 0.9298371 | 0.4389 | NA | NA |
| NRAS | vismodegib | 0.4423058 | 0.9298371 | 0.4423 | NA | NA |
| ATM | vismodegib | 0.4500064 | 0.9298371 | 0.4500 | NA | NA |
| KRAS | vismodegib | 0.4564329 | 0.9298371 | 0.4564 | NA | NA |
| TSC2 | vismodegib | 0.4749053 | 0.9298371 | 0.4749 | NA | NA |
| PDGFRA | vismodegib | 0.4781819 | 0.9298371 | 0.4782 | NA | NA |
| AR | vismodegib | 0.4823074 | 0.9298371 | 0.4823 | NA | NA |
| HRAS | vismodegib | 0.4831149 | 0.9298371 | 0.4831 | NA | NA |
| CBLB | vismodegib | 0.4886928 | 0.9298371 | 0.4887 | NA | NA |
| KMT2A | vismodegib | 0.4929627 | 0.9298371 | 0.4930 | NA | NA |
| IDH1 | vismodegib | 0.4935289 | 0.9298371 | 0.4935 | NA | NA |
| PHF6 | ruxolitinib | 0.7532871 | 0.9309492 | 0.7533 | NA | NA |
| GATA3 | docetaxel | 0.7316455 | 0.9309922 | 0.73165 | NA | NA |
| EGFR | docetaxel | 0.7346881 | 0.9309922 | 0.73469 | NA | NA |
| CEBPA | docetaxel | 0.7376323 | 0.9309922 | 0.73763 | NA | NA |
| DPYD | ponatinib | 0.2315390 | 0.9319012 | 0.232 | NA | NA |
| BCORL1 | ponatinib | 0.2327074 | 0.9319012 | 0.233 | NA | NA |
| KRAS | ponatinib | 0.2496849 | 0.9319012 | 0.250 | NA | NA |
| AKT2 | ponatinib | 0.2512025 | 0.9319012 | 0.251 | NA | NA |
| IDH2 | ponatinib | 0.2610616 | 0.9319012 | 0.261 | NA | NA |
| PTCH1 | ponatinib | 0.2619913 | 0.9319012 | 0.262 | NA | NA |
| U2AF1 | ponatinib | 0.2666179 | 0.9319012 | 0.267 | NA | NA |
| TP53 | ponatinib | 0.2715421 | 0.9319012 | 0.272 | NA | NA |
| PTEN | ponatinib | 0.2782635 | 0.9319012 | 0.278 | NA | NA |
| RIT1 | ponatinib | 0.2845500 | 0.9319012 | 0.285 | NA | NA |
| IDH2 | lapatinib | 0.4399819 | 0.9324389 | 0.4400 | NA | NA |
| KIT | lapatinib | 0.4421047 | 0.9324389 | 0.4421 | NA | NA |
| ALK | alectinib | 0.6916060 | 0.9326870 | 0.6916 | NA | NA |
| SF3B1 | alectinib | 0.6977353 | 0.9326870 | 0.6977 | NA | NA |
| IDH1 | cabozantinib | 0.8618554 | 0.9330831 | 0.8619 | NA | NA |
| JAK1 | dasatinib | 0.7807932 | 0.9337321 | 0.781 | NA | NA |
| EGF | ponatinib | 0.2924029 | 0.9342629 | 0.292 | NA | NA |
| CRLF2 | sunitinib | 0.8629395 | 0.9355232 | 0.863 | NA | NA |
| MAP2K1 | dasatinib | 0.7966385 | 0.9364046 | 0.797 | NA | NA |
| PRPF8 | dasatinib | 0.7991729 | 0.9364046 | 0.799 | NA | NA |
| GNA11 | temozolomide | 0.8144730 | 0.9366589 | 0.81447 | NA | NA |
| RET | temozolomide | 0.8158960 | 0.9366589 | 0.81590 | NA | NA |
| PHF6 | temozolomide | 0.8222578 | 0.9366589 | 0.82226 | NA | NA |
| JAK1 | nilotinib | 0.8549572 | 0.9375475 | 0.8550 | NA | NA |
| WT1 | nilotinib | 0.8552599 | 0.9375475 | 0.8553 | NA | NA |
| BTK | nilotinib | 0.8582165 | 0.9375475 | 0.8582 | NA | NA |
| EML4 | afatinib | 0.7287764 | 0.9378890 | 0.7288 | NA | NA |
| AKT1 | afatinib | 0.7407741 | 0.9378890 | 0.7408 | NA | NA |
| GATA3 | afatinib | 0.7430967 | 0.9378890 | 0.7431 | NA | NA |
| PTCH1 | crizotinib | 0.6605698 | 0.9384433 | 0.6606 | NA | NA |
| PDGFB | crizotinib | 0.6714054 | 0.9384433 | 0.6714 | NA | NA |
| CTNNB1 | crizotinib | 0.6714723 | 0.9384433 | 0.6715 | NA | NA |
| GNAQ | belinostat | 0.2006145 | 0.9385892 | 0.20061 | NA | NA |
| KIT | docetaxel | 0.7747007 | 0.9402755 | 0.77470 | NA | NA |
| PRPF8 | docetaxel | 0.7851088 | 0.9402755 | 0.78511 | NA | NA |
| SH2B3 | docetaxel | 0.7897952 | 0.9402755 | 0.78980 | NA | NA |
| PML | docetaxel | 0.7980096 | 0.9402755 | 0.79801 | NA | NA |
| BCOR | docetaxel | 0.7999167 | 0.9402755 | 0.79992 | NA | NA |
| NRAS | docetaxel | 0.8083668 | 0.9402755 | 0.80837 | NA | NA |
| AR | docetaxel | 0.8129175 | 0.9402755 | 0.81292 | NA | NA |
| VHL | docetaxel | 0.8136685 | 0.9402755 | 0.81367 | NA | NA |
| HRAS | docetaxel | 0.8151657 | 0.9402755 | 0.81517 | NA | NA |
| ETV6 | docetaxel | 0.8173164 | 0.9402755 | 0.81732 | NA | NA |
| SETD2 | palbociclib | 0.8046290 | 0.9403327 | 0.8046 | NA | NA |
| DPYD | palbociclib | 0.8111267 | 0.9403327 | 0.8111 | NA | NA |
| MYD88 | crizotinib | 0.6896981 | 0.9407860 | 0.6897 | NA | NA |
| BRCA1 | crizotinib | 0.7017863 | 0.9407860 | 0.7018 | NA | NA |
| G6PD | crizotinib | 0.7040235 | 0.9407860 | 0.7040 | NA | NA |
| RUNX1 | crizotinib | 0.7117686 | 0.9407860 | 0.7118 | NA | NA |
| NOTCH1 | crizotinib | 0.7257254 | 0.9407860 | 0.7257 | NA | NA |
| PDGFRA | crizotinib | 0.7390621 | 0.9407860 | 0.7391 | NA | NA |
| CREBBP | crizotinib | 0.7392861 | 0.9407860 | 0.7393 | NA | NA |
| ERBB3 | crizotinib | 0.7406129 | 0.9407860 | 0.7406 | NA | NA |
| JAK3 | crizotinib | 0.7461407 | 0.9407860 | 0.7461 | NA | NA |
| MAP2K2 | afatinib | 0.7534845 | 0.9418556 | 0.7535 | NA | NA |
| MAP2K1 | midostaurin | 0.8831837 | 0.9422624 | 0.8832 | NA | NA |
| JAK2 | midostaurin | 0.8847197 | 0.9422624 | 0.8847 | NA | NA |
| ERBB3 | dasatinib | 0.8180600 | 0.9423316 | 0.818 | NA | NA |
| ETV6 | dasatinib | 0.8204783 | 0.9423316 | 0.820 | NA | NA |
| NOTCH2 | lapatinib | 0.4590405 | 0.9424799 | 0.4590 | NA | NA |
| CTNNB1 | lapatinib | 0.4631151 | 0.9424799 | 0.4631 | NA | NA |
| FLT3 | palbociclib | 0.8239049 | 0.9425581 | 0.8239 | NA | NA |
| STAG2 | palbociclib | 0.8274365 | 0.9425581 | 0.8274 | NA | NA |
| SETD2 | gefitinib | 0.8920610 | 0.9428287 | 0.8921 | NA | NA |
| PIK3CA | alectinib | 0.7127369 | 0.9431165 | 0.7127 | NA | NA |
| GATA3 | nilotinib | 0.8715965 | 0.9433014 | 0.8716 | NA | NA |
| NOTCH1 | nilotinib | 0.8779959 | 0.9433014 | 0.8780 | NA | NA |
| SMC1A | rucaparib | 0.4701617 | 0.9438629 | 0.470 | NA | NA |
| PRPF40B | rucaparib | 0.4712034 | 0.9438629 | 0.471 | NA | NA |
| NT5C2 | rucaparib | 0.4816750 | 0.9438629 | 0.482 | NA | NA |
| ETV6 | rucaparib | 0.4827390 | 0.9438629 | 0.483 | NA | NA |
| ESR1 | belinostat | 0.2186179 | 0.9445016 | 0.21862 | NA | NA |
| MYD88 | belinostat | 0.2195610 | 0.9445016 | 0.21956 | NA | NA |
| ROS1 | belinostat | 0.2235080 | 0.9445016 | 0.22351 | NA | NA |
| CRLF2 | midostaurin | 0.8940790 | 0.9445512 | 0.8941 | NA | NA |
| NCOA2 | trametinib | 0.7627476 | 0.9448097 | 0.76275 | NA | NA |
| G6PD | trametinib | 0.7631155 | 0.9448097 | 0.76312 | NA | NA |
| CDK6 | docetaxel | 0.8387669 | 0.9449232 | 0.83877 | NA | NA |
| FANCL | docetaxel | 0.8407316 | 0.9449232 | 0.84073 | NA | NA |
| GNB1 | docetaxel | 0.8431622 | 0.9449232 | 0.84316 | NA | NA |
| KMT2A | rucaparib | 0.4911204 | 0.9451799 | 0.491 | NA | NA |
| CXCR4 | rucaparib | 0.4978429 | 0.9451799 | 0.498 | NA | NA |
| RIT1 | ruxolitinib | 0.7720357 | 0.9452026 | 0.7720 | NA | NA |
| IDH2 | imatinib | 0.7435570 | 0.9454698 | 0.744 | NA | NA |
| CSF3R | imatinib | 0.7445896 | 0.9454698 | 0.745 | NA | NA |
| GATA2 | imatinib | 0.7483981 | 0.9454698 | 0.748 | NA | NA |
| BRCA1 | imatinib | 0.7500850 | 0.9454698 | 0.750 | NA | NA |
| KIT | imatinib | 0.7505218 | 0.9454698 | 0.751 | NA | NA |
| GNAS | imatinib | 0.7623301 | 0.9454698 | 0.762 | NA | NA |
| IL7R | imatinib | 0.7661566 | 0.9454698 | 0.766 | NA | NA |
| PHF6 | nilotinib | 0.8886369 | 0.9469081 | 0.8886 | NA | NA |
| SH2B3 | trametinib | 0.7727573 | 0.9477213 | 0.77276 | NA | NA |
| FGFR1 | cabozantinib | 0.8867029 | 0.9486118 | 0.8867 | NA | NA |
| BRCA2 | cabozantinib | 0.8957636 | 0.9486118 | 0.8958 | NA | NA |
| CREBBP | cabozantinib | 0.9124382 | 0.9486118 | 0.9124 | NA | NA |
| EGFR | cabozantinib | 0.9149328 | 0.9486118 | 0.9149 | NA | NA |
| CBL | cabozantinib | 0.9234314 | 0.9486118 | 0.9234 | NA | NA |
| UGT1A1 | cabozantinib | 0.9262331 | 0.9486118 | 0.9262 | NA | NA |
| SF3B1 | cabozantinib | 0.9332356 | 0.9486118 | 0.9332 | NA | NA |
| ATM | cabozantinib | 0.9341291 | 0.9486118 | 0.9341 | NA | NA |
| CALR | palbociclib | 0.8402810 | 0.9489381 | 0.8403 | NA | NA |
| UGT1A1 | docetaxel | 0.8542969 | 0.9492188 | 0.85430 | NA | NA |
| CTCF | dasatinib | 0.8347924 | 0.9493717 | 0.835 | NA | NA |
| MAP2K2 | temozolomide | 0.8411007 | 0.9498637 | 0.84110 | NA | NA |
| EML4 | dasatinib | 0.8456669 | 0.9501391 | 0.846 | NA | NA |
| MET | dasatinib | 0.8543593 | 0.9501391 | 0.854 | NA | NA |
| IL7R | dasatinib | 0.8625869 | 0.9501391 | 0.863 | NA | NA |
| G6PD | dasatinib | 0.8682306 | 0.9501391 | 0.868 | NA | NA |
| CDK4 | nilotinib | 0.8998193 | 0.9502052 | 0.8998 | NA | NA |
| GATA2 | nilotinib | 0.9063496 | 0.9502052 | 0.9063 | NA | NA |
| PML | vismodegib | 0.5118312 | 0.9505437 | 0.5118 | NA | NA |
| PAX8 | temozolomide | 0.8489663 | 0.9505521 | 0.84897 | NA | NA |
| NCOA2 | docetaxel | 0.8662319 | 0.9509943 | 0.86623 | NA | NA |
| GATA1 | docetaxel | 0.8709152 | 0.9509943 | 0.87092 | NA | NA |
| ERBB4 | docetaxel | 0.8816840 | 0.9509943 | 0.88168 | NA | NA |
| DNAJB1 | docetaxel | 0.8861532 | 0.9509943 | 0.88615 | NA | NA |
| GNAS | docetaxel | 0.8970312 | 0.9509943 | 0.89703 | NA | NA |
| ERBB3 | docetaxel | 0.9076995 | 0.9509943 | 0.90770 | NA | NA |
| PRPF40B | docetaxel | 0.9187358 | 0.9509943 | 0.91874 | NA | NA |
| IL7R | docetaxel | 0.9196203 | 0.9509943 | 0.91962 | NA | NA |
| JAK1 | docetaxel | 0.9217329 | 0.9509943 | 0.92173 | NA | NA |
| SRSF2 | dabrafenib | 0.6268440 | 0.9519179 | 0.62684 | NA | NA |
| FLCN | dabrafenib | 0.6398583 | 0.9519179 | 0.63986 | NA | NA |
| PTPN11 | dabrafenib | 0.6445988 | 0.9519179 | 0.64460 | NA | NA |
| SF1 | dabrafenib | 0.6557616 | 0.9519179 | 0.65576 | NA | NA |
| SMC1A | dabrafenib | 0.6573321 | 0.9519179 | 0.65733 | NA | NA |
| BCOR | dabrafenib | 0.6681638 | 0.9519179 | 0.66816 | NA | NA |
| DNMT3A | dabrafenib | 0.6722330 | 0.9519179 | 0.67223 | NA | NA |
| CEBPA | dabrafenib | 0.6842945 | 0.9519179 | 0.68429 | NA | NA |
| BRCA1 | dabrafenib | 0.6846752 | 0.9519179 | 0.68468 | NA | NA |
| IL7R | dabrafenib | 0.6901632 | 0.9519179 | 0.69016 | NA | NA |
| HRAS | dabrafenib | 0.7049847 | 0.9519179 | 0.70498 | NA | NA |
| RET | dabrafenib | 0.7105653 | 0.9519179 | 0.71057 | NA | NA |
| U2AF1 | dabrafenib | 0.7110632 | 0.9519179 | 0.71106 | NA | NA |
| SF3B1 | dabrafenib | 0.7152721 | 0.9519179 | 0.71527 | NA | NA |
| SMO | dabrafenib | 0.7212576 | 0.9519179 | 0.72126 | NA | NA |
| GNA11 | dabrafenib | 0.7266549 | 0.9519179 | 0.72665 | NA | NA |
| CTLA4 | dabrafenib | 0.7416236 | 0.9524934 | 0.74162 | NA | NA |
| FBXW7 | dabrafenib | 0.7471349 | 0.9524934 | 0.74713 | NA | NA |
| ERBB4 | dabrafenib | 0.7535485 | 0.9524934 | 0.75355 | NA | NA |
| SSX1 | dabrafenib | 0.7561779 | 0.9524934 | 0.75618 | NA | NA |
| SSX1 | ruxolitinib | 0.7939998 | 0.9527661 | 0.7940 | NA | NA |
| ERBB4 | ruxolitinib | 0.7989163 | 0.9527661 | 0.7989 | NA | NA |
| DNAJB1 | ruxolitinib | 0.8017173 | 0.9527661 | 0.8017 | NA | NA |
| IDH2 | ruxolitinib | 0.8073056 | 0.9527661 | 0.8073 | NA | NA |
| CTCF | vismodegib | 0.5249865 | 0.9543342 | 0.5250 | NA | NA |
| NT5C2 | vismodegib | 0.5285543 | 0.9543342 | 0.5286 | NA | NA |
| AKT2 | afatinib | 0.7723890 | 0.9562912 | 0.7724 | NA | NA |
| STAT3 | palbociclib | 0.8543064 | 0.9565311 | 0.8543 | NA | NA |
| ROS1 | palbociclib | 0.8627523 | 0.9578013 | 0.8628 | NA | NA |
| BCORL1 | trametinib | 0.7977582 | 0.9581364 | 0.79776 | NA | NA |
| ERBB3 | trametinib | 0.8021031 | 0.9581364 | 0.80210 | NA | NA |
| CTLA4 | trametinib | 0.8080516 | 0.9581364 | 0.80805 | NA | NA |
| NT5C2 | trametinib | 0.8128743 | 0.9581364 | 0.81287 | NA | NA |
| PHF6 | trametinib | 0.8279218 | 0.9581364 | 0.82792 | NA | NA |
| MET | trametinib | 0.8326323 | 0.9581364 | 0.83263 | NA | NA |
| CXCR4 | trametinib | 0.8340020 | 0.9581364 | 0.83400 | NA | NA |
| GNAS | trametinib | 0.8402119 | 0.9581364 | 0.84021 | NA | NA |
| JAK2 | pazopanib | 0.8907594 | 0.9590344 | 0.8908 | NA | NA |
| MPL | pazopanib | 0.8975234 | 0.9590344 | 0.8975 | NA | NA |
| NT5C2 | pazopanib | 0.9014251 | 0.9590344 | 0.9014 | NA | NA |
| NOTCH1 | pazopanib | 0.9077883 | 0.9590344 | 0.9078 | NA | NA |
| SMC3 | crizotinib | 0.7765258 | 0.9596512 | 0.7765 | NA | NA |
| EGF | crizotinib | 0.7795860 | 0.9596512 | 0.7796 | NA | NA |
| PDGFRB | crizotinib | 0.8019048 | 0.9596512 | 0.8019 | NA | NA |
| ZRSR2 | crizotinib | 0.8231357 | 0.9596512 | 0.8231 | NA | NA |
| WHSC1 | crizotinib | 0.8232275 | 0.9596512 | 0.8232 | NA | NA |
| CBLB | crizotinib | 0.8413325 | 0.9596512 | 0.8413 | NA | NA |
| EML4 | crizotinib | 0.8463945 | 0.9596512 | 0.8464 | NA | NA |
| KRAS | crizotinib | 0.8512775 | 0.9596512 | 0.8513 | NA | NA |
| CXCR4 | crizotinib | 0.8549228 | 0.9596512 | 0.8549 | NA | NA |
| CD79B | crizotinib | 0.8619832 | 0.9596512 | 0.8620 | NA | NA |
| GNAQ | crizotinib | 0.8619832 | 0.9596512 | 0.8620 | NA | NA |
| SF3B1 | crizotinib | 0.8672340 | 0.9596512 | 0.8672 | NA | NA |
| KIT | crizotinib | 0.8686498 | 0.9596512 | 0.8686 | NA | NA |
| FGFR2 | sunitinib | 0.8937255 | 0.9599274 | 0.894 | NA | NA |
| TSC1 | gefitinib | 0.9156569 | 0.9599629 | 0.9157 | NA | NA |
| GATA2 | lapatinib | 0.4800955 | 0.9601909 | 0.4801 | NA | NA |
| SETD2 | temozolomide | 0.8680092 | 0.9609503 | 0.86801 | NA | NA |
| SRSF2 | temozolomide | 0.8729244 | 0.9609503 | 0.87292 | NA | NA |
| DDIT3 | rucaparib | 0.5186394 | 0.9613594 | 0.519 | NA | NA |
| FGFR3 | rucaparib | 0.5246724 | 0.9613594 | 0.525 | NA | NA |
| CEBPA | rucaparib | 0.5399967 | 0.9613594 | 0.540 | NA | NA |
| FBXW7 | rucaparib | 0.5434920 | 0.9613594 | 0.543 | NA | NA |
| BTK | rucaparib | 0.5488597 | 0.9613594 | 0.549 | NA | NA |
| G6PD | rucaparib | 0.5646292 | 0.9613594 | 0.565 | NA | NA |
| BRCA1 | rucaparib | 0.5768966 | 0.9613594 | 0.577 | NA | NA |
| ALK | rucaparib | 0.5819295 | 0.9613594 | 0.582 | NA | NA |
| TSC2 | rucaparib | 0.5851976 | 0.9613594 | 0.585 | NA | NA |
| STAT3 | rucaparib | 0.5946002 | 0.9613594 | 0.595 | NA | NA |
| PML | rucaparib | 0.5950165 | 0.9613594 | 0.595 | NA | NA |
| SMO | rucaparib | 0.6056010 | 0.9613594 | 0.606 | NA | NA |
| FGFR1 | rucaparib | 0.6079969 | 0.9613594 | 0.608 | NA | NA |
| SETD2 | rucaparib | 0.6306943 | 0.9613594 | 0.631 | NA | NA |
| ASXL1 | rucaparib | 0.6357840 | 0.9613594 | 0.636 | NA | NA |
| CD79B | rucaparib | 0.6412203 | 0.9613594 | 0.641 | NA | NA |
| NPM1 | rucaparib | 0.6448258 | 0.9613594 | 0.645 | NA | NA |
| PHF6 | rucaparib | 0.6451245 | 0.9613594 | 0.645 | NA | NA |
| PDGFB | rucaparib | 0.6469333 | 0.9613594 | 0.647 | NA | NA |
| NRAS | rucaparib | 0.6737269 | 0.9613594 | 0.674 | NA | NA |
| CDK4 | rucaparib | 0.6760802 | 0.9613594 | 0.676 | NA | NA |
| AKT1 | rucaparib | 0.6766724 | 0.9613594 | 0.677 | NA | NA |
| ERBB2 | rucaparib | 0.6813788 | 0.9613594 | 0.681 | NA | NA |
| KRAS | rucaparib | 0.6847697 | 0.9613594 | 0.685 | NA | NA |
| FGFR2 | rucaparib | 0.7108197 | 0.9613594 | 0.711 | NA | NA |
| HRAS | rucaparib | 0.7110377 | 0.9613594 | 0.711 | NA | NA |
| ERBB3 | rucaparib | 0.7263040 | 0.9613594 | 0.726 | NA | NA |
| FANCL | rucaparib | 0.7358289 | 0.9613594 | 0.736 | NA | NA |
| CSF3R | rucaparib | 0.7397162 | 0.9613594 | 0.740 | NA | NA |
| ATM | rucaparib | 0.7486752 | 0.9613594 | 0.749 | NA | NA |
| MAP2K1 | rucaparib | 0.7521890 | 0.9613594 | 0.752 | NA | NA |
| PAX8 | rucaparib | 0.7606800 | 0.9613594 | 0.761 | NA | NA |
| TPMT | rucaparib | 0.7619662 | 0.9613594 | 0.762 | NA | NA |
| STAG2 | rucaparib | 0.7624445 | 0.9613594 | 0.762 | NA | NA |
| GATA2 | rucaparib | 0.7793422 | 0.9613594 | 0.779 | NA | NA |
| JAK1 | rucaparib | 0.7793843 | 0.9613594 | 0.779 | NA | NA |
| EGFR | rucaparib | 0.7812134 | 0.9613594 | 0.781 | NA | NA |
| MET | rucaparib | 0.7852325 | 0.9613594 | 0.785 | NA | NA |
| WT1 | vismodegib | 0.5404655 | 0.9624727 | 0.5405 | NA | NA |
| ZRSR2 | erlotinib | 0.8179957 | 0.9632433 | 0.8180 | NA | NA |
| CREBBP | erlotinib | 0.8208508 | 0.9632433 | 0.8209 | NA | NA |
| MYD88 | imatinib | 0.7889569 | 0.9633579 | 0.789 | NA | NA |
| CTCF | pazopanib | 0.9276294 | 0.9636959 | 0.9276 | NA | NA |
| AR | pazopanib | 0.9277609 | 0.9636959 | 0.9278 | NA | NA |
| STAT3 | pazopanib | 0.9342701 | 0.9636959 | 0.9343 | NA | NA |
| CYP19A1 | lapatinib | 0.4937490 | 0.9639975 | 0.4937 | NA | NA |
| ERBB3 | lapatinib | 0.5028840 | 0.9639975 | 0.5029 | NA | NA |
| GATA1 | lapatinib | 0.5069297 | 0.9639975 | 0.5069 | NA | NA |
| PRPF8 | erlotinib | 0.8511983 | 0.9642623 | 0.8512 | NA | NA |
| DPYD | erlotinib | 0.8604995 | 0.9642623 | 0.8605 | NA | NA |
| GNB1 | erlotinib | 0.8604995 | 0.9642623 | 0.8605 | NA | NA |
| ERBB4 | erlotinib | 0.8652272 | 0.9642623 | 0.8652 | NA | NA |
| CXCR4 | erlotinib | 0.8802653 | 0.9642623 | 0.8803 | NA | NA |
| EML4 | erlotinib | 0.8868224 | 0.9642623 | 0.8868 | NA | NA |
| TET2 | erlotinib | 0.8873786 | 0.9642623 | 0.8874 | NA | NA |
| SETD2 | erlotinib | 0.9034192 | 0.9642623 | 0.9034 | NA | NA |
| ESR1 | erlotinib | 0.9133687 | 0.9642623 | 0.9134 | NA | NA |
| CBLB | erlotinib | 0.9170458 | 0.9642623 | 0.9170 | NA | NA |
| EGFR | erlotinib | 0.9218958 | 0.9642623 | 0.9219 | NA | NA |
| PTCH1 | erlotinib | 0.9275623 | 0.9642623 | 0.9276 | NA | NA |
| RET | erlotinib | 0.9307227 | 0.9642623 | 0.9307 | NA | NA |
| PTCH1 | rucaparib | 0.7952280 | 0.9645822 | 0.795 | NA | NA |
| AKT3 | rucaparib | 0.8101446 | 0.9647678 | 0.810 | NA | NA |
| WHSC1 | rucaparib | 0.8131544 | 0.9647678 | 0.813 | NA | NA |
| TET2 | rucaparib | 0.8260219 | 0.9647678 | 0.826 | NA | NA |
| CYP19A1 | rucaparib | 0.8350834 | 0.9647678 | 0.835 | NA | NA |
| RET | rucaparib | 0.8423514 | 0.9647678 | 0.842 | NA | NA |
| UGT1A1 | rucaparib | 0.8467310 | 0.9647678 | 0.847 | NA | NA |
| GATA3 | rucaparib | 0.8515819 | 0.9647678 | 0.852 | NA | NA |
| CTNNB1 | rucaparib | 0.8579792 | 0.9647678 | 0.858 | NA | NA |
| PAX5 | rucaparib | 0.8616629 | 0.9647678 | 0.862 | NA | NA |
| WT1 | alectinib | 0.7365097 | 0.9648277 | 0.7365 | NA | NA |
| PIGA | alectinib | 0.7603016 | 0.9650018 | 0.7603 | NA | NA |
| DNMT3A | alectinib | 0.7613631 | 0.9650018 | 0.7614 | NA | NA |
| MGMT | alectinib | 0.7636616 | 0.9650018 | 0.7637 | NA | NA |
| CBLB | alectinib | 0.7661083 | 0.9650018 | 0.7661 | NA | NA |
| MYD88 | gefitinib | 0.9283678 | 0.9655025 | 0.9284 | NA | NA |
| FGFR2 | dasatinib | 0.8929128 | 0.9655770 | 0.893 | NA | NA |
| MGMT | dasatinib | 0.8989855 | 0.9655770 | 0.899 | NA | NA |
| FLT3 | ruxolitinib | 0.8312495 | 0.9657969 | 0.8312 | NA | NA |
| FBXW7 | ruxolitinib | 0.8330920 | 0.9657969 | 0.8331 | NA | NA |
| GATA1 | vismodegib | 0.5583929 | 0.9659607 | 0.5584 | NA | NA |
| CSF3R | vismodegib | 0.5693374 | 0.9659607 | 0.5693 | NA | NA |
| BTK | vismodegib | 0.5724794 | 0.9659607 | 0.5725 | NA | NA |
| PRPF8 | vismodegib | 0.5766264 | 0.9659607 | 0.5766 | NA | NA |
| FBXW7 | vismodegib | 0.5934236 | 0.9659607 | 0.5934 | NA | NA |
| CDK6 | vismodegib | 0.5972260 | 0.9659607 | 0.5972 | NA | NA |
| MYD88 | vismodegib | 0.5979041 | 0.9659607 | 0.5979 | NA | NA |
| ERBB4 | vismodegib | 0.6099615 | 0.9659607 | 0.6100 | NA | NA |
| GATA2 | vismodegib | 0.6168478 | 0.9659607 | 0.6168 | NA | NA |
| PDCD1 | vismodegib | 0.6201762 | 0.9659607 | 0.6202 | NA | NA |
| MPL | vismodegib | 0.6241592 | 0.9659607 | 0.6242 | NA | NA |
| AR | palbociclib | 0.8839747 | 0.9665899 | 0.8840 | NA | NA |
| CTLA4 | palbociclib | 0.8909703 | 0.9665899 | 0.8910 | NA | NA |
| PRPF40B | palbociclib | 0.8948596 | 0.9665899 | 0.8949 | NA | NA |
| SMC1A | palbociclib | 0.9001829 | 0.9665899 | 0.9002 | NA | NA |
| RPL10 | temozolomide | 0.8989536 | 0.9673953 | 0.89895 | NA | NA |
| AKT1 | temozolomide | 0.9094399 | 0.9673953 | 0.90944 | NA | NA |
| KMT2A | temozolomide | 0.9165748 | 0.9673953 | 0.91657 | NA | NA |
| G6PD | temozolomide | 0.9184100 | 0.9673953 | 0.91841 | NA | NA |
| SF3B1 | temozolomide | 0.9259576 | 0.9673953 | 0.92596 | NA | NA |
| EML4 | temozolomide | 0.9305234 | 0.9673953 | 0.93052 | NA | NA |
| BTK | temozolomide | 0.9330073 | 0.9673953 | 0.93301 | NA | NA |
| FANCL | temozolomide | 0.9438077 | 0.9673953 | 0.94381 | NA | NA |
| CSF3R | temozolomide | 0.9503618 | 0.9673953 | 0.95036 | NA | NA |
| BRCA1 | temozolomide | 0.9526259 | 0.9673953 | 0.95263 | NA | NA |
| DDIT3 | afatinib | 0.7931329 | 0.9681667 | 0.7931 | NA | NA |
| FLT3 | afatinib | 0.8043606 | 0.9681667 | 0.8044 | NA | NA |
| NCOA2 | afatinib | 0.8224551 | 0.9681667 | 0.8225 | NA | NA |
| PRPF8 | afatinib | 0.8232418 | 0.9681667 | 0.8232 | NA | NA |
| JAK1 | afatinib | 0.8434616 | 0.9681667 | 0.8435 | NA | NA |
| JAK3 | afatinib | 0.8440781 | 0.9681667 | 0.8441 | NA | NA |
| FLCN | afatinib | 0.8573994 | 0.9681667 | 0.8574 | NA | NA |
| RUNX1 | afatinib | 0.8597949 | 0.9681667 | 0.8598 | NA | NA |
| CRLF2 | afatinib | 0.8603484 | 0.9681667 | 0.8603 | NA | NA |
| GNAQ | afatinib | 0.8603484 | 0.9681667 | 0.8603 | NA | NA |
| NPM1 | afatinib | 0.8655570 | 0.9681667 | 0.8656 | NA | NA |
| WHSC1 | afatinib | 0.8804758 | 0.9681667 | 0.8805 | NA | NA |
| AR | afatinib | 0.8812495 | 0.9681667 | 0.8812 | NA | NA |
| IDH1 | afatinib | 0.8943509 | 0.9681667 | 0.8944 | NA | NA |
| IKZF1 | afatinib | 0.8947795 | 0.9681667 | 0.8948 | NA | NA |
| BRAF | afatinib | 0.9011510 | 0.9681667 | 0.9012 | NA | NA |
| BCOR | afatinib | 0.9121893 | 0.9681667 | 0.9122 | NA | NA |
| NT5C2 | afatinib | 0.9160346 | 0.9681667 | 0.9160 | NA | NA |
| GNAQ | cabozantinib | 0.9622409 | 0.9696427 | 0.9622 | NA | NA |
| WT1 | ruxolitinib | 0.8454506 | 0.9709306 | 0.8455 | NA | NA |
| JAK2 | ruxolitinib | 0.8523436 | 0.9709306 | 0.8523 | NA | NA |
| ROS1 | crizotinib | 0.9055984 | 0.9716963 | 0.9056 | NA | NA |
| CDKN2A | crizotinib | 0.9099113 | 0.9716963 | 0.9099 | NA | NA |
| JAK1 | crizotinib | 0.9136622 | 0.9716963 | 0.9137 | NA | NA |
| TP53 | crizotinib | 0.9190956 | 0.9716963 | 0.9191 | NA | NA |
| IDH1 | crizotinib | 0.9332905 | 0.9716963 | 0.9333 | NA | NA |
| MYCN | crizotinib | 0.9332905 | 0.9716963 | 0.9333 | NA | NA |
| BTK | crizotinib | 0.9381895 | 0.9716963 | 0.9382 | NA | NA |
| BRCA2 | sunitinib | 0.9151190 | 0.9719215 | 0.915 | NA | NA |
| NPM1 | sunitinib | 0.9216497 | 0.9719215 | 0.922 | NA | NA |
| RIT1 | trametinib | 0.8654388 | 0.9719490 | 0.86544 | NA | NA |
| NPM1 | trametinib | 0.8672776 | 0.9719490 | 0.86728 | NA | NA |
| FLCN | temozolomide | 0.9645329 | 0.9719524 | 0.96453 | NA | NA |
| FANCL | lapatinib | 0.5224774 | 0.9721633 | 0.5225 | NA | NA |
| JAK3 | lapatinib | 0.5279853 | 0.9721633 | 0.5280 | NA | NA |
| STAT3 | dabrafenib | 0.7798325 | 0.9729339 | 0.77983 | NA | NA |
| PTCH1 | belinostat | 0.2376997 | 0.9730830 | 0.23770 | NA | NA |
| SETD2 | docetaxel | 0.9506315 | 0.9730874 | 0.95063 | NA | NA |
| TSC1 | afatinib | 0.9300086 | 0.9743215 | 0.9300 | NA | NA |
| ESR1 | afatinib | 0.9503087 | 0.9743215 | 0.9503 | NA | NA |
| FGFR2 | afatinib | 0.9511520 | 0.9743215 | 0.9512 | NA | NA |
| PML | afatinib | 0.9518372 | 0.9743215 | 0.9518 | NA | NA |
| VHL | cabozantinib | 0.9746401 | 0.9746401 | 0.9746 | NA | NA |
| TP53 | alectinib | 0.7812268 | 0.9746735 | 0.7812 | NA | NA |
| RET | pazopanib | 0.9581510 | 0.9747513 | 0.9582 | NA | NA |
| CXCR4 | pazopanib | 0.9598696 | 0.9747513 | 0.9599 | NA | NA |
| BRAF | dasatinib | 0.9161548 | 0.9749904 | 0.916 | NA | NA |
| PDCD1 | tretinoin | 0.9379623 | 0.9754808 | 0.9380 | NA | NA |
| XPO1 | midostaurin | 0.9469456 | 0.9775663 | 0.9469 | NA | NA |
| IDH2 | midostaurin | 0.9477169 | 0.9775663 | 0.9477 | NA | NA |
| RIT1 | midostaurin | 0.9477169 | 0.9775663 | 0.9477 | NA | NA |
| AKT1 | docetaxel | 0.9695144 | 0.9786645 | 0.96951 | NA | NA |
| SMC3 | docetaxel | 0.9711363 | 0.9786645 | 0.97114 | NA | NA |
| RIT1 | temozolomide | 0.9786787 | 0.9786787 | 0.97868 | NA | NA |
| RET | midostaurin | 0.9563247 | 0.9787385 | 0.9563 | NA | NA |
| ETV6 | erlotinib | 0.9532871 | 0.9788215 | 0.9533 | NA | NA |
| SH2B3 | bosutinib monohydrate | 0.0467380 | 0.9795951 | 0.0467 |
|
NA |
| TSC1 | bosutinib monohydrate | 0.0576889 | 0.9795951 | 0.0577 | NA | NA |
| VHL | bosutinib monohydrate | 0.0669017 | 0.9795951 | 0.0669 | NA | NA |
| CDKN2A | bosutinib monohydrate | 0.0688711 | 0.9795951 | 0.0689 | NA | NA |
| CTLA4 | bosutinib monohydrate | 0.0999893 | 0.9795951 | 0.1000 | NA | NA |
| BTK | bosutinib monohydrate | 0.1001931 | 0.9795951 | 0.1002 | NA | NA |
| MAP2K2 | bosutinib monohydrate | 0.1046536 | 0.9795951 | 0.1047 | NA | NA |
| G6PD | bosutinib monohydrate | 0.1162560 | 0.9795951 | 0.1163 | NA | NA |
| RPL10 | bosutinib monohydrate | 0.1218958 | 0.9795951 | 0.1219 | NA | NA |
| UGT1A1 | bosutinib monohydrate | 0.1252560 | 0.9795951 | 0.1253 | NA | NA |
| GATA2 | bosutinib monohydrate | 0.1441992 | 0.9795951 | 0.1442 | NA | NA |
| AKT1 | bosutinib monohydrate | 0.1516806 | 0.9795951 | 0.1517 | NA | NA |
| GNAS | bosutinib monohydrate | 0.1636359 | 0.9795951 | 0.1636 | NA | NA |
| GATA1 | bosutinib monohydrate | 0.1718658 | 0.9795951 | 0.1719 | NA | NA |
| PTCH1 | bosutinib monohydrate | 0.1879013 | 0.9795951 | 0.1879 | NA | NA |
| MAP2K1 | bosutinib monohydrate | 0.2099067 | 0.9795951 | 0.2099 | NA | NA |
| PTPN11 | bosutinib monohydrate | 0.2124694 | 0.9795951 | 0.2125 | NA | NA |
| SF1 | bosutinib monohydrate | 0.2126871 | 0.9795951 | 0.2127 | NA | NA |
| BCORL1 | bosutinib monohydrate | 0.2167334 | 0.9795951 | 0.2167 | NA | NA |
| PAX5 | bosutinib monohydrate | 0.2299628 | 0.9795951 | 0.2300 | NA | NA |
| PDCD1 | bosutinib monohydrate | 0.2330839 | 0.9795951 | 0.2331 | NA | NA |
| EGF | bosutinib monohydrate | 0.2453569 | 0.9795951 | 0.2454 | NA | NA |
| CBLB | bosutinib monohydrate | 0.2461824 | 0.9795951 | 0.2462 | NA | NA |
| IDH2 | bosutinib monohydrate | 0.2477175 | 0.9795951 | 0.2477 | NA | NA |
| CTNNB1 | bosutinib monohydrate | 0.2477885 | 0.9795951 | 0.2478 | NA | NA |
| BRCA1 | bosutinib monohydrate | 0.2550079 | 0.9795951 | 0.2550 | NA | NA |
| SMC1A | bosutinib monohydrate | 0.2743651 | 0.9795951 | 0.2744 | NA | NA |
| RIT1 | bosutinib monohydrate | 0.2754670 | 0.9795951 | 0.2755 | NA | NA |
| EML4 | bosutinib monohydrate | 0.2755994 | 0.9795951 | 0.2756 | NA | NA |
| DNAJB1 | bosutinib monohydrate | 0.2768690 | 0.9795951 | 0.2769 | NA | NA |
| GNB1 | bosutinib monohydrate | 0.2886360 | 0.9795951 | 0.2886 | NA | NA |
| BRCA2 | bosutinib monohydrate | 0.2907814 | 0.9795951 | 0.2908 | NA | NA |
| ROS1 | bosutinib monohydrate | 0.2963370 | 0.9795951 | 0.2963 | NA | NA |
| PAX8 | bosutinib monohydrate | 0.3070631 | 0.9795951 | 0.3071 | NA | NA |
| NOTCH1 | bosutinib monohydrate | 0.3085065 | 0.9795951 | 0.3085 | NA | NA |
| SF3B1 | bosutinib monohydrate | 0.3173562 | 0.9795951 | 0.3174 | NA | NA |
| RAD21 | bosutinib monohydrate | 0.3221870 | 0.9795951 | 0.3222 | NA | NA |
| CDC73 | bosutinib monohydrate | 0.3226723 | 0.9795951 | 0.3227 | NA | NA |
| TET2 | bosutinib monohydrate | 0.3227747 | 0.9795951 | 0.3228 | NA | NA |
| ERBB3 | bosutinib monohydrate | 0.3381914 | 0.9795951 | 0.3382 | NA | NA |
| CEBPA | bosutinib monohydrate | 0.3405298 | 0.9795951 | 0.3405 | NA | NA |
| GNAQ | bosutinib monohydrate | 0.3420516 | 0.9795951 | 0.3421 | NA | NA |
| MET | bosutinib monohydrate | 0.3480988 | 0.9795951 | 0.3481 | NA | NA |
| STAG2 | bosutinib monohydrate | 0.3541613 | 0.9795951 | 0.3542 | NA | NA |
| GATA3 | erlotinib | 0.9653874 | 0.9799657 | 0.9654 | NA | NA |
| MDM2 | erlotinib | 0.9714442 | 0.9799657 | 0.9714 | NA | NA |
| MAP2K2 | tretinoin | 0.9548035 | 0.9803243 | 0.9548 | NA | NA |
| GATA1 | tretinoin | 0.9577014 | 0.9803243 | 0.9577 | NA | NA |
| NOTCH1 | dabrafenib | 0.7939637 | 0.9812193 | 0.79396 | NA | NA |
| FLT3 | alectinib | 0.7941809 | 0.9814878 | 0.7942 | NA | NA |
| EED | palbociclib | 0.9217317 | 0.9816817 | 0.9217 | NA | NA |
| STAT3 | trametinib | 0.8932780 | 0.9821514 | 0.89328 | NA | NA |
| PML | trametinib | 0.8969530 | 0.9821514 | 0.89695 | NA | NA |
| SSX1 | trametinib | 0.8990463 | 0.9821514 | 0.89905 | NA | NA |
| ERBB4 | pazopanib | 0.9762228 | 0.9837322 | 0.9762 | NA | NA |
| SETD2 | crizotinib | 0.9583372 | 0.9837798 | 0.9583 | NA | NA |
| NOTCH2 | trametinib | 0.9359551 | 0.9839656 | 0.93596 | NA | NA |
| VHL | trametinib | 0.9375075 | 0.9839656 | 0.93751 | NA | NA |
| FBXW7 | trametinib | 0.9408952 | 0.9839656 | 0.94090 | NA | NA |
| BRCA2 | trametinib | 0.9421624 | 0.9839656 | 0.94216 | NA | NA |
| SMO | trametinib | 0.9533365 | 0.9839656 | 0.95334 | NA | NA |
| PRPF8 | trametinib | 0.9559535 | 0.9839656 | 0.95595 | NA | NA |
| PAX5 | trametinib | 0.9686829 | 0.9839656 | 0.96868 | NA | NA |
| AKT2 | trametinib | 0.9713673 | 0.9839656 | 0.97137 | NA | NA |
| PDGFRB | trametinib | 0.9784811 | 0.9839656 | 0.97848 | NA | NA |
| PIK3CA | trametinib | 0.9832477 | 0.9839656 | 0.98325 | NA | NA |
| PAX8 | trametinib | 0.9839656 | 0.9839656 | 0.98397 | NA | NA |
| ASXL1 | sunitinib | 0.9421871 | 0.9842410 | 0.942 | NA | NA |
| CBLB | sunitinib | 0.9503016 | 0.9842410 | 0.950 | NA | NA |
| STAG2 | dasatinib | 0.9411192 | 0.9852367 | 0.941 | NA | NA |
| ROS1 | dasatinib | 0.9512458 | 0.9852367 | 0.951 | NA | NA |
| AKT2 | dasatinib | 0.9512631 | 0.9852367 | 0.951 | NA | NA |
| TET2 | sunitinib | 0.9597590 | 0.9852393 | 0.960 | NA | NA |
| NOTCH1 | imatinib | 0.8157654 | 0.9857165 | 0.816 | NA | NA |
| NPM1 | bosutinib monohydrate | 0.3813570 | 0.9862194 | 0.3814 | NA | NA |
| ERBB2 | bosutinib monohydrate | 0.3828642 | 0.9862194 | 0.3829 | NA | NA |
| MDM2 | bosutinib monohydrate | 0.3854602 | 0.9862194 | 0.3855 | NA | NA |
| IL7R | bosutinib monohydrate | 0.3981162 | 0.9862194 | 0.3981 | NA | NA |
| PDGFRA | bosutinib monohydrate | 0.4175132 | 0.9862194 | 0.4175 | NA | NA |
| ZRSR2 | bosutinib monohydrate | 0.4214919 | 0.9862194 | 0.4215 | NA | NA |
| ASXL1 | bosutinib monohydrate | 0.4226760 | 0.9862194 | 0.4227 | NA | NA |
| CXCR4 | bosutinib monohydrate | 0.4378881 | 0.9862194 | 0.4379 | NA | NA |
| SETD2 | bosutinib monohydrate | 0.4409242 | 0.9862194 | 0.4409 | NA | NA |
| U2AF1 | bosutinib monohydrate | 0.4415049 | 0.9862194 | 0.4415 | NA | NA |
| PML | bosutinib monohydrate | 0.4556704 | 0.9862194 | 0.4557 | NA | NA |
| MPL | bosutinib monohydrate | 0.4577383 | 0.9862194 | 0.4577 | NA | NA |
| DPYD | bosutinib monohydrate | 0.4594664 | 0.9862194 | 0.4595 | NA | NA |
| XPO1 | bosutinib monohydrate | 0.4627645 | 0.9862194 | 0.4628 | NA | NA |
| PDGFRA | dasatinib | 0.9608776 | 0.9863876 | 0.961 | NA | NA |
| PTEN | dabrafenib | 0.8142047 | 0.9866077 | 0.81420 | NA | NA |
| PRPF8 | dabrafenib | 0.8146043 | 0.9866077 | 0.81460 | NA | NA |
| TSC1 | dabrafenib | 0.8273766 | 0.9866077 | 0.82738 | NA | NA |
| EML4 | dabrafenib | 0.8284492 | 0.9866077 | 0.82845 | NA | NA |
| BRCA2 | ruxolitinib | 0.8869414 | 0.9866703 | 0.8869 | NA | NA |
| SETD2 | ruxolitinib | 0.8932673 | 0.9866703 | 0.8933 | NA | NA |
| CDK4 | ruxolitinib | 0.8949990 | 0.9866703 | 0.8950 | NA | NA |
| ROS1 | ruxolitinib | 0.8966205 | 0.9866703 | 0.8966 | NA | NA |
| CD79B | ruxolitinib | 0.9154477 | 0.9866703 | 0.9154 | NA | NA |
| PDGFRA | ruxolitinib | 0.9248089 | 0.9866703 | 0.9248 | NA | NA |
| EML4 | ruxolitinib | 0.9311316 | 0.9866703 | 0.9311 | NA | NA |
| PRPF8 | ruxolitinib | 0.9509706 | 0.9866703 | 0.9510 | NA | NA |
| UGT1A1 | ruxolitinib | 0.9514154 | 0.9866703 | 0.9514 | NA | NA |
| MPL | ruxolitinib | 0.9628412 | 0.9866703 | 0.9628 | NA | NA |
| CRLF2 | ruxolitinib | 0.9649859 | 0.9866703 | 0.9650 | NA | NA |
| AKT2 | ruxolitinib | 0.9698154 | 0.9866703 | 0.9698 | NA | NA |
| GATA2 | ruxolitinib | 0.9725671 | 0.9866703 | 0.9726 | NA | NA |
| ATM | ruxolitinib | 0.9769582 | 0.9866703 | 0.9770 | NA | NA |
| SMC1A | ruxolitinib | 0.9791385 | 0.9866703 | 0.9791 | NA | NA |
| XPO1 | belinostat | 0.2503343 | 0.9870331 | 0.25033 | NA | NA |
| HRAS | belinostat | 0.2579401 | 0.9870331 | 0.25794 | NA | NA |
| JAK3 | belinostat | 0.2699558 | 0.9870331 | 0.26996 | NA | NA |
| ALK | belinostat | 0.2712457 | 0.9870331 | 0.27125 | NA | NA |
| SH2B3 | gefitinib | 0.9659820 | 0.9877838 | 0.9660 | NA | NA |
| NCOA2 | gefitinib | 0.9667617 | 0.9877838 | 0.9668 | NA | NA |
| AKT3 | gefitinib | 0.9813410 | 0.9877838 | 0.9813 | NA | NA |
| ATM | gefitinib | 0.9830253 | 0.9877838 | 0.9830 | NA | NA |
| KMT2A | gefitinib | 0.9877838 | 0.9877838 | 0.9878 | NA | NA |
| GNAS | lapatinib | 0.5469657 | 0.9878187 | 0.5470 | NA | NA |
| FLT3 | lapatinib | 0.5679419 | 0.9878187 | 0.5679 | NA | NA |
| CDK6 | lapatinib | 0.5808070 | 0.9878187 | 0.5808 | NA | NA |
| EGFR | lapatinib | 0.5960871 | 0.9878187 | 0.5961 | NA | NA |
| MDM2 | lapatinib | 0.6102843 | 0.9878187 | 0.6103 | NA | NA |
| TP53 | lapatinib | 0.6134430 | 0.9878187 | 0.6134 | NA | NA |
| FGFR2 | lapatinib | 0.6157059 | 0.9878187 | 0.6157 | NA | NA |
| ZRSR2 | lapatinib | 0.6268747 | 0.9878187 | 0.6269 | NA | NA |
| ETV6 | lapatinib | 0.6320960 | 0.9878187 | 0.6321 | NA | NA |
| KRAS | lapatinib | 0.6456344 | 0.9878187 | 0.6456 | NA | NA |
| SETBP1 | lapatinib | 0.6547184 | 0.9878187 | 0.6547 | NA | NA |
| CTCF | lapatinib | 0.6732294 | 0.9878187 | 0.6732 | NA | NA |
| STAT3 | lapatinib | 0.6790984 | 0.9878187 | 0.6791 | NA | NA |
| ESR1 | lapatinib | 0.6823352 | 0.9878187 | 0.6823 | NA | NA |
| RAD21 | lapatinib | 0.6950648 | 0.9878187 | 0.6951 | NA | NA |
| IKZF1 | lapatinib | 0.7149708 | 0.9878187 | 0.7150 | NA | NA |
| ASXL1 | lapatinib | 0.7456852 | 0.9878187 | 0.7457 | NA | NA |
| MAP2K1 | lapatinib | 0.7574056 | 0.9878187 | 0.7574 | NA | NA |
| AKT2 | lapatinib | 0.7662055 | 0.9878187 | 0.7662 | NA | NA |
| PDGFRA | lapatinib | 0.7718304 | 0.9878187 | 0.7718 | NA | NA |
| EGF | lapatinib | 0.7810119 | 0.9878187 | 0.7810 | NA | NA |
| WHSC1 | lapatinib | 0.7912577 | 0.9878187 | 0.7913 | NA | NA |
| SF1 | lapatinib | 0.8001540 | 0.9878187 | 0.8002 | NA | NA |
| MPL | lapatinib | 0.8048218 | 0.9878187 | 0.8048 | NA | NA |
| PIGA | lapatinib | 0.8104666 | 0.9878187 | 0.8105 | NA | NA |
| CREBBP | lapatinib | 0.8151862 | 0.9878187 | 0.8152 | NA | NA |
| PRPF40B | lapatinib | 0.8171082 | 0.9878187 | 0.8171 | NA | NA |
| KMT2A | lapatinib | 0.8228845 | 0.9878187 | 0.8229 | NA | NA |
| FGFR1 | lapatinib | 0.8287747 | 0.9878187 | 0.8288 | NA | NA |
| CSF3R | lapatinib | 0.8590618 | 0.9878187 | 0.8591 | NA | NA |
| U2AF1 | lapatinib | 0.8687945 | 0.9878187 | 0.8688 | NA | NA |
| DNMT3A | lapatinib | 0.8744953 | 0.9878187 | 0.8745 | NA | NA |
| STAG2 | lapatinib | 0.8799391 | 0.9878187 | 0.8799 | NA | NA |
| WT1 | lapatinib | 0.8836758 | 0.9878187 | 0.8837 | NA | NA |
| JAK1 | lapatinib | 0.8879653 | 0.9878187 | 0.8880 | NA | NA |
| BTK | lapatinib | 0.8911322 | 0.9878187 | 0.8911 | NA | NA |
| PTEN | lapatinib | 0.8993258 | 0.9878187 | 0.8993 | NA | NA |
| CDKN2A | lapatinib | 0.9091620 | 0.9878187 | 0.9092 | NA | NA |
| EML4 | lapatinib | 0.9110932 | 0.9878187 | 0.9111 | NA | NA |
| BRCA1 | lapatinib | 0.9142372 | 0.9878187 | 0.9142 | NA | NA |
| JAK2 | lapatinib | 0.9210478 | 0.9878187 | 0.9210 | NA | NA |
| PRPF8 | lapatinib | 0.9234249 | 0.9878187 | 0.9234 | NA | NA |
| ROS1 | lapatinib | 0.9246091 | 0.9878187 | 0.9246 | NA | NA |
| MYD88 | lapatinib | 0.9323054 | 0.9878187 | 0.9323 | NA | NA |
| IL7R | lapatinib | 0.9384466 | 0.9878187 | 0.9384 | NA | NA |
| BCOR | lapatinib | 0.9510755 | 0.9878187 | 0.9511 | NA | NA |
| BRAF | lapatinib | 0.9579143 | 0.9878187 | 0.9579 | NA | NA |
| XPO1 | lapatinib | 0.9630445 | 0.9878187 | 0.9630 | NA | NA |
| NT5C2 | lapatinib | 0.9661181 | 0.9878187 | 0.9661 | NA | NA |
| G6PD | lapatinib | 0.9681165 | 0.9878187 | 0.9681 | NA | NA |
| PML | lapatinib | 0.9738117 | 0.9878187 | 0.9738 | NA | NA |
| PIK3CA | lapatinib | 0.9866347 | 0.9878187 | 0.9866 | NA | NA |
| PTCH1 | lapatinib | 0.9878187 | 0.9878187 | 0.9878 | NA | NA |
| JAK3 | bosutinib monohydrate | 0.4728655 | 0.9889279 | 0.4729 | NA | NA |
| BCOR | bosutinib monohydrate | 0.4792497 | 0.9889279 | 0.4792 | NA | NA |
| ALK | vismodegib | 0.6657344 | 0.9892602 | 0.6657 | NA | NA |
| JAK3 | vismodegib | 0.6747353 | 0.9892602 | 0.6747 | NA | NA |
| PAX8 | vismodegib | 0.6926534 | 0.9892602 | 0.6927 | NA | NA |
| ROS1 | vismodegib | 0.7075936 | 0.9892602 | 0.7076 | NA | NA |
| FGFR1 | vismodegib | 0.7176988 | 0.9892602 | 0.7177 | NA | NA |
| PTCH1 | vismodegib | 0.7198241 | 0.9892602 | 0.7198 | NA | NA |
| FLCN | vismodegib | 0.7262828 | 0.9892602 | 0.7263 | NA | NA |
| PHF6 | vismodegib | 0.7268066 | 0.9892602 | 0.7268 | NA | NA |
| MDM2 | vismodegib | 0.7273768 | 0.9892602 | 0.7274 | NA | NA |
| CXCR4 | vismodegib | 0.7331174 | 0.9892602 | 0.7331 | NA | NA |
| PIK3CA | vismodegib | 0.7343535 | 0.9892602 | 0.7344 | NA | NA |
| CALR | vismodegib | 0.7414134 | 0.9892602 | 0.7414 | NA | NA |
| MYCN | vismodegib | 0.7563157 | 0.9892602 | 0.7563 | NA | NA |
| ERBB2 | vismodegib | 0.7739594 | 0.9892602 | 0.7740 | NA | NA |
| CDKN2A | vismodegib | 0.7751324 | 0.9892602 | 0.7751 | NA | NA |
| EGF | vismodegib | 0.7936091 | 0.9892602 | 0.7936 | NA | NA |
| AKT2 | vismodegib | 0.7962512 | 0.9892602 | 0.7963 | NA | NA |
| NPM1 | vismodegib | 0.8004491 | 0.9892602 | 0.8004 | NA | NA |
| PTPN11 | vismodegib | 0.8117817 | 0.9892602 | 0.8118 | NA | NA |
| IL7R | vismodegib | 0.8119458 | 0.9892602 | 0.8119 | NA | NA |
| SETBP1 | vismodegib | 0.8431988 | 0.9892602 | 0.8432 | NA | NA |
| DDIT3 | vismodegib | 0.8486410 | 0.9892602 | 0.8486 | NA | NA |
| CRLF2 | vismodegib | 0.8514764 | 0.9892602 | 0.8515 | NA | NA |
| FGFR2 | vismodegib | 0.8556611 | 0.9892602 | 0.8557 | NA | NA |
| GNB1 | vismodegib | 0.8642884 | 0.9892602 | 0.8643 | NA | NA |
| UGT1A1 | vismodegib | 0.8657073 | 0.9892602 | 0.8657 | NA | NA |
| ERBB3 | vismodegib | 0.8804120 | 0.9892602 | 0.8804 | NA | NA |
| SMO | vismodegib | 0.8914996 | 0.9892602 | 0.8915 | NA | NA |
| U2AF1 | vismodegib | 0.9095190 | 0.9892602 | 0.9095 | NA | NA |
| ASXL1 | vismodegib | 0.9095642 | 0.9892602 | 0.9096 | NA | NA |
| CREBBP | vismodegib | 0.9238700 | 0.9892602 | 0.9239 | NA | NA |
| AKT3 | vismodegib | 0.9378898 | 0.9892602 | 0.9379 | NA | NA |
| MGMT | vismodegib | 0.9400649 | 0.9892602 | 0.9401 | NA | NA |
| SSX1 | vismodegib | 0.9409047 | 0.9892602 | 0.9409 | NA | NA |
| EGFR | vismodegib | 0.9448114 | 0.9892602 | 0.9448 | NA | NA |
| ABL1 | vismodegib | 0.9494533 | 0.9892602 | 0.9495 | NA | NA |
| CD79B | vismodegib | 0.9553598 | 0.9892602 | 0.9554 | NA | NA |
| SF1 | vismodegib | 0.9658373 | 0.9892602 | 0.9658 | NA | NA |
| BCORL1 | vismodegib | 0.9665371 | 0.9892602 | 0.9665 | NA | NA |
| CYP19A1 | vismodegib | 0.9723531 | 0.9892602 | 0.9724 | NA | NA |
| BRCA2 | vismodegib | 0.9733078 | 0.9892602 | 0.9733 | NA | NA |
| PIGA | vismodegib | 0.9761297 | 0.9892602 | 0.9761 | NA | NA |
| FLT3 | vismodegib | 0.9773105 | 0.9892602 | 0.9773 | NA | NA |
| PRPF40B | vismodegib | 0.9793061 | 0.9892602 | 0.9793 | NA | NA |
| CTNNB1 | vismodegib | 0.9841264 | 0.9892602 | 0.9841 | NA | NA |
| DNAJB1 | vismodegib | 0.9892602 | 0.9892602 | 0.9893 | NA | NA |
| MDM2 | dasatinib | 0.9723856 | 0.9894450 | 0.972 | NA | NA |
| SSX1 | nilotinib | 0.9563025 | 0.9907003 | 0.9563 | NA | NA |
| ASXL1 | nilotinib | 0.9628343 | 0.9907003 | 0.9628 | NA | NA |
| DPYD | nilotinib | 0.9678380 | 0.9907003 | 0.9678 | NA | NA |
| CBLB | afatinib | 0.9770926 | 0.9923597 | 0.9771 | NA | NA |
| MET | alectinib | 0.8262519 | 0.9927405 | 0.8263 | NA | NA |
| CDK4 | alectinib | 0.8384108 | 0.9927405 | 0.8384 | NA | NA |
| CBL | alectinib | 0.8404483 | 0.9927405 | 0.8404 | NA | NA |
| PRPF40B | alectinib | 0.8649658 | 0.9927405 | 0.8650 | NA | NA |
| CXCR4 | alectinib | 0.8726340 | 0.9927405 | 0.8726 | NA | NA |
| CDC73 | alectinib | 0.8729260 | 0.9927405 | 0.8729 | NA | NA |
| FGFR3 | alectinib | 0.8924433 | 0.9927405 | 0.8924 | NA | NA |
| BCOR | alectinib | 0.8960633 | 0.9927405 | 0.8961 | NA | NA |
| CRLF2 | alectinib | 0.9059455 | 0.9927405 | 0.9059 | NA | NA |
| PRPF8 | alectinib | 0.9120043 | 0.9927405 | 0.9120 | NA | NA |
| SH2B3 | alectinib | 0.9243076 | 0.9927405 | 0.9243 | NA | NA |
| CREBBP | alectinib | 0.9297312 | 0.9927405 | 0.9297 | NA | NA |
| MYCN | alectinib | 0.9314131 | 0.9927405 | 0.9314 | NA | NA |
| IDH1 | alectinib | 0.9344033 | 0.9927405 | 0.9344 | NA | NA |
| CALR | alectinib | 0.9372021 | 0.9927405 | 0.9372 | NA | NA |
| NCOA2 | alectinib | 0.9388572 | 0.9927405 | 0.9389 | NA | NA |
| IDH2 | alectinib | 0.9437117 | 0.9927405 | 0.9437 | NA | NA |
| CSF3R | alectinib | 0.9447105 | 0.9927405 | 0.9447 | NA | NA |
| SRSF2 | alectinib | 0.9507839 | 0.9927405 | 0.9508 | NA | NA |
| KIT | alectinib | 0.9692528 | 0.9927405 | 0.9693 | NA | NA |
| WHSC1 | alectinib | 0.9757368 | 0.9927405 | 0.9757 | NA | NA |
| NRAS | alectinib | 0.9762797 | 0.9927405 | 0.9763 | NA | NA |
| KRAS | alectinib | 0.9838427 | 0.9927405 | 0.9838 | NA | NA |
| ESR1 | alectinib | 0.9851623 | 0.9927405 | 0.9852 | NA | NA |
| PAX8 | midostaurin | 0.9789346 | 0.9941119 | 0.9789 | NA | NA |
| ETV6 | sunitinib | 0.9847737 | 0.9944188 | 0.985 | NA | NA |
| CTCF | sunitinib | 0.9858463 | 0.9944188 | 0.986 | NA | NA |
| MGMT | ruxolitinib | 0.9946721 | 0.9946721 | 0.9947 | NA | NA |
| BCOR | crizotinib | 0.9890817 | 0.9948625 | 0.9891 | NA | NA |
| FBXW7 | crizotinib | 0.9940455 | 0.9948625 | 0.9940 | NA | NA |
| PHF6 | crizotinib | 0.9948625 | 0.9948625 | 0.9949 | NA | NA |
| EZH2 | dabrafenib | 0.8492920 | 0.9949724 | 0.84929 | NA | NA |
| BTK | dabrafenib | 0.8535378 | 0.9949724 | 0.85354 | NA | NA |
| PRPF40B | dabrafenib | 0.8607282 | 0.9949724 | 0.86073 | NA | NA |
| RIT1 | dabrafenib | 0.8669500 | 0.9949724 | 0.86695 | NA | NA |
| PAX5 | dabrafenib | 0.8814339 | 0.9949724 | 0.88143 | NA | NA |
| MYCN | dabrafenib | 0.8835841 | 0.9949724 | 0.88358 | NA | NA |
| GATA3 | dabrafenib | 0.9004044 | 0.9949724 | 0.90040 | NA | NA |
| CYP19A1 | dabrafenib | 0.9107211 | 0.9949724 | 0.91072 | NA | NA |
| FGFR1 | dabrafenib | 0.9151888 | 0.9949724 | 0.91519 | NA | NA |
| BRCA2 | dabrafenib | 0.9168207 | 0.9949724 | 0.91682 | NA | NA |
| GATA2 | dabrafenib | 0.9389490 | 0.9949724 | 0.93895 | NA | NA |
| PIGA | dabrafenib | 0.9436553 | 0.9949724 | 0.94366 | NA | NA |
| AR | dabrafenib | 0.9681760 | 0.9949724 | 0.96818 | NA | NA |
| IDH2 | dabrafenib | 0.9684328 | 0.9949724 | 0.96843 | NA | NA |
| FANCL | dabrafenib | 0.9732873 | 0.9949724 | 0.97329 | NA | NA |
| SMC3 | dabrafenib | 0.9734466 | 0.9949724 | 0.97345 | NA | NA |
| AKT2 | dabrafenib | 0.9755082 | 0.9949724 | 0.97551 | NA | NA |
| MYD88 | dabrafenib | 0.9773916 | 0.9949724 | 0.97739 | NA | NA |
| WHSC1 | dabrafenib | 0.9865696 | 0.9949724 | 0.98657 | NA | NA |
| FGFR2 | dabrafenib | 0.9883831 | 0.9949724 | 0.98838 | NA | NA |
| ROS1 | dabrafenib | 0.9949724 | 0.9949724 | 0.99497 | NA | NA |
| SMO | alectinib | 0.9950076 | 0.9950076 | 0.9950 | NA | NA |
| GNB1 | midostaurin | 0.9890693 | 0.9959831 | 0.9891 | NA | NA |
| CDKN2A | midostaurin | 0.9959831 | 0.9959831 | 0.9960 | NA | NA |
| PTEN | dasatinib | 0.9918913 | 0.9962487 | 0.992 | NA | NA |
| ZRSR2 | dasatinib | 0.9962487 | 0.9962487 | 0.996 | NA | NA |
| PAX8 | sunitinib | 0.9962773 | 0.9962773 | 0.996 | NA | NA |
| IDH2 | palbociclib | 0.9443484 | 0.9964898 | 0.9443 | NA | NA |
| PAX5 | palbociclib | 0.9597535 | 0.9964898 | 0.9598 | NA | NA |
| FBXW7 | palbociclib | 0.9637857 | 0.9964898 | 0.9638 | NA | NA |
| BCOR | palbociclib | 0.9763682 | 0.9964898 | 0.9764 | NA | NA |
| AKT2 | palbociclib | 0.9809077 | 0.9964898 | 0.9809 | NA | NA |
| CTCF | palbociclib | 0.9812762 | 0.9964898 | 0.9813 | NA | NA |
| KMT2A | tretinoin | 0.9867957 | 0.9968006 | 0.9868 | NA | NA |
| FGFR2 | tretinoin | 0.9899834 | 0.9968006 | 0.9900 | NA | NA |
| ABL1 | tretinoin | 0.9968006 | 0.9968006 | 0.9968 | NA | NA |
| ATM | palbociclib | 0.9892046 | 0.9968139 | 0.9892 | NA | NA |
| NT5C2 | belinostat | 0.3123377 | 0.9969037 | 0.31234 | NA | NA |
| KRAS | belinostat | 0.3158051 | 0.9969037 | 0.31581 | NA | NA |
| CYP19A1 | belinostat | 0.3161498 | 0.9969037 | 0.31615 | NA | NA |
| PIGA | belinostat | 0.3336508 | 0.9969037 | 0.33365 | NA | NA |
| GNB1 | belinostat | 0.3441703 | 0.9969037 | 0.34417 | NA | NA |
| CTCF | belinostat | 0.3467750 | 0.9969037 | 0.34678 | NA | NA |
| EZH2 | belinostat | 0.3495023 | 0.9969037 | 0.34950 | NA | NA |
| BRCA2 | belinostat | 0.3501637 | 0.9969037 | 0.35016 | NA | NA |
| IL7R | belinostat | 0.3785808 | 0.9969037 | 0.37858 | NA | NA |
| ERBB3 | belinostat | 0.3891061 | 0.9969037 | 0.38911 | NA | NA |
| DDIT3 | belinostat | 0.3972274 | 0.9969037 | 0.39723 | NA | NA |
| UGT1A1 | belinostat | 0.4041103 | 0.9969037 | 0.40411 | NA | NA |
| PIK3CA | belinostat | 0.4072121 | 0.9969037 | 0.40721 | NA | NA |
| SMC3 | belinostat | 0.4229260 | 0.9969037 | 0.42293 | NA | NA |
| PRPF40B | belinostat | 0.4230525 | 0.9969037 | 0.42305 | NA | NA |
| JAK2 | belinostat | 0.4239919 | 0.9969037 | 0.42399 | NA | NA |
| ASXL1 | belinostat | 0.4246638 | 0.9969037 | 0.42466 | NA | NA |
| CRLF2 | belinostat | 0.4451357 | 0.9969037 | 0.44514 | NA | NA |
| ERBB4 | belinostat | 0.4469217 | 0.9969037 | 0.44692 | NA | NA |
| FGFR2 | belinostat | 0.4626400 | 0.9969037 | 0.46264 | NA | NA |
| FGFR1 | belinostat | 0.4651801 | 0.9969037 | 0.46518 | NA | NA |
| BRCA1 | belinostat | 0.4653768 | 0.9969037 | 0.46538 | NA | NA |
| CDC73 | belinostat | 0.4780499 | 0.9969037 | 0.47805 | NA | NA |
| G6PD | belinostat | 0.4798818 | 0.9969037 | 0.47988 | NA | NA |
| WT1 | belinostat | 0.4865711 | 0.9969037 | 0.48657 | NA | NA |
| STAT3 | belinostat | 0.5022511 | 0.9969037 | 0.50225 | NA | NA |
| CDKN2A | belinostat | 0.5154714 | 0.9969037 | 0.51547 | NA | NA |
| MPL | belinostat | 0.5173049 | 0.9969037 | 0.51730 | NA | NA |
| GATA2 | belinostat | 0.5271314 | 0.9969037 | 0.52713 | NA | NA |
| CD79B | belinostat | 0.5522460 | 0.9969037 | 0.55225 | NA | NA |
| AKT1 | belinostat | 0.5547454 | 0.9969037 | 0.55475 | NA | NA |
| ZRSR2 | belinostat | 0.5551241 | 0.9969037 | 0.55512 | NA | NA |
| RUNX1 | belinostat | 0.5560288 | 0.9969037 | 0.55603 | NA | NA |
| PAX8 | belinostat | 0.5590195 | 0.9969037 | 0.55902 | NA | NA |
| MGMT | belinostat | 0.5789471 | 0.9969037 | 0.57895 | NA | NA |
| GNA11 | belinostat | 0.5851873 | 0.9969037 | 0.58519 | NA | NA |
| NOTCH2 | belinostat | 0.5876845 | 0.9969037 | 0.58768 | NA | NA |
| FLCN | belinostat | 0.5905635 | 0.9969037 | 0.59056 | NA | NA |
| WHSC1 | belinostat | 0.5965935 | 0.9969037 | 0.59659 | NA | NA |
| CBLB | belinostat | 0.6024277 | 0.9969037 | 0.60243 | NA | NA |
| SRSF2 | belinostat | 0.6119949 | 0.9969037 | 0.61199 | NA | NA |
| PRPF8 | belinostat | 0.6148581 | 0.9969037 | 0.61486 | NA | NA |
| PDGFB | belinostat | 0.6267736 | 0.9969037 | 0.62677 | NA | NA |
| CEBPA | belinostat | 0.6359932 | 0.9969037 | 0.63599 | NA | NA |
| GATA3 | belinostat | 0.6548206 | 0.9969037 | 0.65482 | NA | NA |
| FLT3 | belinostat | 0.6686147 | 0.9969037 | 0.66861 | NA | NA |
| JAK1 | belinostat | 0.6717499 | 0.9969037 | 0.67175 | NA | NA |
| CXCR4 | belinostat | 0.6735809 | 0.9969037 | 0.67358 | NA | NA |
| PDCD1 | belinostat | 0.6759501 | 0.9969037 | 0.67595 | NA | NA |
| EGFR | belinostat | 0.6783585 | 0.9969037 | 0.67836 | NA | NA |
| SF3B1 | belinostat | 0.6860819 | 0.9969037 | 0.68608 | NA | NA |
| RET | belinostat | 0.6890334 | 0.9969037 | 0.68903 | NA | NA |
| GATA1 | belinostat | 0.7010507 | 0.9969037 | 0.70105 | NA | NA |
| TET2 | belinostat | 0.7026106 | 0.9969037 | 0.70261 | NA | NA |
| TSC2 | belinostat | 0.7089749 | 0.9969037 | 0.70897 | NA | NA |
| AR | belinostat | 0.7191374 | 0.9969037 | 0.71914 | NA | NA |
| CDK4 | belinostat | 0.7399640 | 0.9969037 | 0.73996 | NA | NA |
| PDGFRA | belinostat | 0.7450686 | 0.9969037 | 0.74507 | NA | NA |
| PML | belinostat | 0.7463779 | 0.9969037 | 0.74638 | NA | NA |
| NOTCH1 | belinostat | 0.7507540 | 0.9969037 | 0.75075 | NA | NA |
| CREBBP | belinostat | 0.7547871 | 0.9969037 | 0.75479 | NA | NA |
| SSX1 | belinostat | 0.7759031 | 0.9969037 | 0.77590 | NA | NA |
| CTLA4 | belinostat | 0.7879627 | 0.9969037 | 0.78796 | NA | NA |
| AKT2 | belinostat | 0.7986070 | 0.9969037 | 0.79861 | NA | NA |
| MYCN | belinostat | 0.8021438 | 0.9969037 | 0.80214 | NA | NA |
| DPYD | belinostat | 0.8079628 | 0.9969037 | 0.80796 | NA | NA |
| SETD2 | belinostat | 0.8095851 | 0.9969037 | 0.80959 | NA | NA |
| IKZF1 | belinostat | 0.8113724 | 0.9969037 | 0.81137 | NA | NA |
| MAP2K1 | belinostat | 0.8327077 | 0.9969037 | 0.83271 | NA | NA |
| PHF6 | belinostat | 0.8666835 | 0.9969037 | 0.86668 | NA | NA |
| SMO | belinostat | 0.8688884 | 0.9969037 | 0.86889 | NA | NA |
| AKT3 | belinostat | 0.8831307 | 0.9969037 | 0.88313 | NA | NA |
| EML4 | belinostat | 0.8965070 | 0.9969037 | 0.89651 | NA | NA |
| TSC1 | belinostat | 0.9061702 | 0.9969037 | 0.90617 | NA | NA |
| ATM | belinostat | 0.9231828 | 0.9969037 | 0.92318 | NA | NA |
| CTNNB1 | belinostat | 0.9260261 | 0.9969037 | 0.92603 | NA | NA |
| CALR | belinostat | 0.9275787 | 0.9969037 | 0.92758 | NA | NA |
| FBXW7 | belinostat | 0.9290017 | 0.9969037 | 0.92900 | NA | NA |
| KIT | belinostat | 0.9303304 | 0.9969037 | 0.93033 | NA | NA |
| PAX5 | belinostat | 0.9366113 | 0.9969037 | 0.93661 | NA | NA |
| CDK6 | belinostat | 0.9369710 | 0.9969037 | 0.93697 | NA | NA |
| MDM2 | belinostat | 0.9372150 | 0.9969037 | 0.93721 | NA | NA |
| RPL10 | belinostat | 0.9410297 | 0.9969037 | 0.94103 | NA | NA |
| CSF3R | belinostat | 0.9429053 | 0.9969037 | 0.94291 | NA | NA |
| RAD21 | belinostat | 0.9463328 | 0.9969037 | 0.94633 | NA | NA |
| ETV6 | belinostat | 0.9514347 | 0.9969037 | 0.95143 | NA | NA |
| FANCL | belinostat | 0.9517795 | 0.9969037 | 0.95178 | NA | NA |
| SMC1A | belinostat | 0.9581409 | 0.9969037 | 0.95814 | NA | NA |
| BTK | belinostat | 0.9628687 | 0.9969037 | 0.96287 | NA | NA |
| GNAS | belinostat | 0.9662777 | 0.9969037 | 0.96628 | NA | NA |
| DNMT3A | belinostat | 0.9723117 | 0.9969037 | 0.97231 | NA | NA |
| U2AF1 | belinostat | 0.9762326 | 0.9969037 | 0.97623 | NA | NA |
| EED | belinostat | 0.9816838 | 0.9969037 | 0.98168 | NA | NA |
| CTCF | ponatinib | 0.3280080 | 0.9972326 | 0.328 | NA | NA |
| GNB1 | ponatinib | 0.3304650 | 0.9972326 | 0.330 | NA | NA |
| NRAS | ponatinib | 0.3414906 | 0.9972326 | 0.341 | NA | NA |
| G6PD | ponatinib | 0.3562978 | 0.9972326 | 0.356 | NA | NA |
| AKT3 | ponatinib | 0.3621735 | 0.9972326 | 0.362 | NA | NA |
| MDM2 | ponatinib | 0.3814458 | 0.9972326 | 0.381 | NA | NA |
| SETBP1 | ponatinib | 0.3902213 | 0.9972326 | 0.390 | NA | NA |
| RUNX1 | ponatinib | 0.3986659 | 0.9972326 | 0.399 | NA | NA |
| DDIT3 | ponatinib | 0.4091577 | 0.9972326 | 0.409 | NA | NA |
| WHSC1 | ponatinib | 0.4135038 | 0.9972326 | 0.414 | NA | NA |
| EML4 | ponatinib | 0.4160407 | 0.9972326 | 0.416 | NA | NA |
| BTK | ponatinib | 0.4171885 | 0.9972326 | 0.417 | NA | NA |
| MPL | ponatinib | 0.4233079 | 0.9972326 | 0.423 | NA | NA |
| SETD2 | ponatinib | 0.4289630 | 0.9972326 | 0.429 | NA | NA |
| BRCA1 | ponatinib | 0.4319743 | 0.9972326 | 0.432 | NA | NA |
| CD79B | ponatinib | 0.4546022 | 0.9972326 | 0.455 | NA | NA |
| MYCN | ponatinib | 0.4565739 | 0.9972326 | 0.457 | NA | NA |
| PAX8 | ponatinib | 0.4661236 | 0.9972326 | 0.466 | NA | NA |
| BRCA2 | ponatinib | 0.4687534 | 0.9972326 | 0.469 | NA | NA |
| PDGFB | ponatinib | 0.4821695 | 0.9972326 | 0.482 | NA | NA |
| IKZF1 | ponatinib | 0.4960463 | 0.9972326 | 0.496 | NA | NA |
| HRAS | ponatinib | 0.5102704 | 0.9972326 | 0.510 | NA | NA |
| PHF6 | ponatinib | 0.5333653 | 0.9972326 | 0.533 | NA | NA |
| SSX1 | ponatinib | 0.5376169 | 0.9972326 | 0.538 | NA | NA |
| RAD21 | ponatinib | 0.5382645 | 0.9972326 | 0.538 | NA | NA |
| ETV6 | ponatinib | 0.5414576 | 0.9972326 | 0.541 | NA | NA |
| SMO | ponatinib | 0.5427786 | 0.9972326 | 0.543 | NA | NA |
| MGMT | ponatinib | 0.5540759 | 0.9972326 | 0.554 | NA | NA |
| CTNNB1 | ponatinib | 0.5759382 | 0.9972326 | 0.576 | NA | NA |
| JAK3 | ponatinib | 0.5765409 | 0.9972326 | 0.577 | NA | NA |
| RET | ponatinib | 0.5838741 | 0.9972326 | 0.584 | NA | NA |
| NPM1 | ponatinib | 0.5854791 | 0.9972326 | 0.585 | NA | NA |
| EGFR | ponatinib | 0.5861711 | 0.9972326 | 0.586 | NA | NA |
| TSC1 | ponatinib | 0.6125905 | 0.9972326 | 0.613 | NA | NA |
| MET | ponatinib | 0.6159349 | 0.9972326 | 0.616 | NA | NA |
| PML | ponatinib | 0.6178115 | 0.9972326 | 0.618 | NA | NA |
| SF1 | ponatinib | 0.6198294 | 0.9972326 | 0.620 | NA | NA |
| ZRSR2 | ponatinib | 0.6253285 | 0.9972326 | 0.625 | NA | NA |
| DNMT3A | ponatinib | 0.6448404 | 0.9972326 | 0.645 | NA | NA |
| XPO1 | ponatinib | 0.6457762 | 0.9972326 | 0.646 | NA | NA |
| CD274 | ponatinib | 0.6479420 | 0.9972326 | 0.648 | NA | NA |
| FLT3 | ponatinib | 0.6691061 | 0.9972326 | 0.669 | NA | NA |
| IDH1 | ponatinib | 0.6713059 | 0.9972326 | 0.671 | NA | NA |
| PDGFRA | ponatinib | 0.6831311 | 0.9972326 | 0.683 | NA | NA |
| GATA3 | ponatinib | 0.6899584 | 0.9972326 | 0.690 | NA | NA |
| UGT1A1 | ponatinib | 0.7062488 | 0.9972326 | 0.706 | NA | NA |
| WT1 | ponatinib | 0.7147828 | 0.9972326 | 0.715 | NA | NA |
| CDK4 | ponatinib | 0.7179383 | 0.9972326 | 0.718 | NA | NA |
| PDGFRB | ponatinib | 0.7240517 | 0.9972326 | 0.724 | NA | NA |
| GATA2 | ponatinib | 0.7335798 | 0.9972326 | 0.734 | NA | NA |
| FLCN | ponatinib | 0.7349618 | 0.9972326 | 0.735 | NA | NA |
| CBL | ponatinib | 0.7373495 | 0.9972326 | 0.737 | NA | NA |
| PRPF40B | ponatinib | 0.7385033 | 0.9972326 | 0.739 | NA | NA |
| CYP19A1 | ponatinib | 0.7421820 | 0.9972326 | 0.742 | NA | NA |
| NT5C2 | ponatinib | 0.7573545 | 0.9972326 | 0.757 | NA | NA |
| FGFR3 | ponatinib | 0.7753615 | 0.9972326 | 0.775 | NA | NA |
| CBLB | ponatinib | 0.7877705 | 0.9972326 | 0.788 | NA | NA |
| BRAF | ponatinib | 0.7903167 | 0.9972326 | 0.790 | NA | NA |
| NOTCH2 | ponatinib | 0.8034028 | 0.9972326 | 0.803 | NA | NA |
| VHL | ponatinib | 0.8280799 | 0.9972326 | 0.828 | NA | NA |
| NCOA2 | ponatinib | 0.8286775 | 0.9972326 | 0.829 | NA | NA |
| STAG2 | ponatinib | 0.8454770 | 0.9972326 | 0.845 | NA | NA |
| MAP2K1 | ponatinib | 0.8469335 | 0.9972326 | 0.847 | NA | NA |
| FGFR1 | ponatinib | 0.8480615 | 0.9972326 | 0.848 | NA | NA |
| SF3B1 | ponatinib | 0.8491288 | 0.9972326 | 0.849 | NA | NA |
| MYD88 | ponatinib | 0.8552763 | 0.9972326 | 0.855 | NA | NA |
| ERBB4 | ponatinib | 0.8558847 | 0.9972326 | 0.856 | NA | NA |
| ESR1 | ponatinib | 0.8695576 | 0.9972326 | 0.870 | NA | NA |
| PDCD1 | ponatinib | 0.8703157 | 0.9972326 | 0.870 | NA | NA |
| KMT2A | ponatinib | 0.8723076 | 0.9972326 | 0.872 | NA | NA |
| TPMT | ponatinib | 0.8811769 | 0.9972326 | 0.881 | NA | NA |
| CEBPA | ponatinib | 0.8994044 | 0.9972326 | 0.899 | NA | NA |
| GATA1 | ponatinib | 0.9103985 | 0.9972326 | 0.910 | NA | NA |
| SMC3 | ponatinib | 0.9106175 | 0.9972326 | 0.911 | NA | NA |
| ERBB2 | ponatinib | 0.9158815 | 0.9972326 | 0.916 | NA | NA |
| PIK3CA | ponatinib | 0.9215126 | 0.9972326 | 0.922 | NA | NA |
| PRPF8 | ponatinib | 0.9216621 | 0.9972326 | 0.922 | NA | NA |
| NOTCH1 | ponatinib | 0.9235323 | 0.9972326 | 0.924 | NA | NA |
| KIT | ponatinib | 0.9257639 | 0.9972326 | 0.926 | NA | NA |
| GNAQ | ponatinib | 0.9286811 | 0.9972326 | 0.929 | NA | NA |
| MAP2K2 | ponatinib | 0.9308325 | 0.9972326 | 0.931 | NA | NA |
| CRLF2 | ponatinib | 0.9548438 | 0.9972326 | 0.955 | NA | NA |
| ALK | ponatinib | 0.9561548 | 0.9972326 | 0.956 | NA | NA |
| SMC1A | ponatinib | 0.9617697 | 0.9972326 | 0.962 | NA | NA |
| BCOR | ponatinib | 0.9670462 | 0.9972326 | 0.967 | NA | NA |
| AR | ponatinib | 0.9737798 | 0.9972326 | 0.974 | NA | NA |
| PAX5 | ponatinib | 0.9765095 | 0.9972326 | 0.977 | NA | NA |
| JAK2 | ponatinib | 0.9882767 | 0.9972326 | 0.988 | NA | NA |
| EED | ponatinib | 0.9938213 | 0.9972326 | 0.994 | NA | NA |
| AKT1 | ponatinib | 0.9972326 | 0.9972326 | 0.997 | NA | NA |
| SH2B3 | belinostat | 0.9899582 | 0.9975732 | 0.98996 | NA | NA |
| PHF6 | palbociclib | 0.9984149 | 0.9984149 | 0.9984 | NA | NA |
| KMT2A | bosutinib monohydrate | 0.4965364 | 0.9984574 | 0.4965 | NA | NA |
| NOTCH2 | bosutinib monohydrate | 0.5054644 | 0.9984574 | 0.5055 | NA | NA |
| SMC3 | bosutinib monohydrate | 0.5290075 | 0.9984574 | 0.5290 | NA | NA |
| CTCF | bosutinib monohydrate | 0.5335475 | 0.9984574 | 0.5335 | NA | NA |
| RET | bosutinib monohydrate | 0.5509591 | 0.9984574 | 0.5510 | NA | NA |
| IKZF1 | bosutinib monohydrate | 0.5599796 | 0.9984574 | 0.5600 | NA | NA |
| CD79B | bosutinib monohydrate | 0.5670616 | 0.9984574 | 0.5671 | NA | NA |
| AKT3 | bosutinib monohydrate | 0.5766764 | 0.9984574 | 0.5767 | NA | NA |
| AKT2 | bosutinib monohydrate | 0.6027318 | 0.9984574 | 0.6027 | NA | NA |
| SETBP1 | bosutinib monohydrate | 0.6114437 | 0.9984574 | 0.6114 | NA | NA |
| MGMT | bosutinib monohydrate | 0.6222029 | 0.9984574 | 0.6222 | NA | NA |
| TSC2 | bosutinib monohydrate | 0.6543872 | 0.9984574 | 0.6544 | NA | NA |
| CBL | bosutinib monohydrate | 0.6620191 | 0.9984574 | 0.6620 | NA | NA |
| PRPF40B | bosutinib monohydrate | 0.6722945 | 0.9984574 | 0.6723 | NA | NA |
| NT5C2 | bosutinib monohydrate | 0.6791919 | 0.9984574 | 0.6792 | NA | NA |
| PHF6 | bosutinib monohydrate | 0.6899414 | 0.9984574 | 0.6899 | NA | NA |
| CYP19A1 | bosutinib monohydrate | 0.6902719 | 0.9984574 | 0.6903 | NA | NA |
| CD274 | bosutinib monohydrate | 0.6927838 | 0.9984574 | 0.6928 | NA | NA |
| PTEN | bosutinib monohydrate | 0.6935476 | 0.9984574 | 0.6935 | NA | NA |
| PRPF8 | bosutinib monohydrate | 0.7291900 | 0.9984574 | 0.7292 | NA | NA |
| KRAS | bosutinib monohydrate | 0.7414809 | 0.9984574 | 0.7415 | NA | NA |
| PDGFRB | bosutinib monohydrate | 0.7429860 | 0.9984574 | 0.7430 | NA | NA |
| FANCL | bosutinib monohydrate | 0.7442638 | 0.9984574 | 0.7443 | NA | NA |
| SMO | bosutinib monohydrate | 0.7478513 | 0.9984574 | 0.7479 | NA | NA |
| DNMT3A | bosutinib monohydrate | 0.7551741 | 0.9984574 | 0.7552 | NA | NA |
| FGFR1 | bosutinib monohydrate | 0.7589059 | 0.9984574 | 0.7589 | NA | NA |
| PDGFB | bosutinib monohydrate | 0.7637526 | 0.9984574 | 0.7638 | NA | NA |
| IDH1 | bosutinib monohydrate | 0.7658117 | 0.9984574 | 0.7658 | NA | NA |
| ETV6 | bosutinib monohydrate | 0.7705523 | 0.9984574 | 0.7706 | NA | NA |
| ABL1 | bosutinib monohydrate | 0.7708229 | 0.9984574 | 0.7708 | NA | NA |
| WHSC1 | bosutinib monohydrate | 0.7917104 | 0.9984574 | 0.7917 | NA | NA |
| JAK1 | bosutinib monohydrate | 0.7934737 | 0.9984574 | 0.7935 | NA | NA |
| CDK6 | bosutinib monohydrate | 0.7961993 | 0.9984574 | 0.7962 | NA | NA |
| SSX1 | bosutinib monohydrate | 0.8010644 | 0.9984574 | 0.8011 | NA | NA |
| ERBB4 | bosutinib monohydrate | 0.8029349 | 0.9984574 | 0.8029 | NA | NA |
| STAT3 | bosutinib monohydrate | 0.8055766 | 0.9984574 | 0.8056 | NA | NA |
| ESR1 | bosutinib monohydrate | 0.8080005 | 0.9984574 | 0.8080 | NA | NA |
| CREBBP | bosutinib monohydrate | 0.8213056 | 0.9984574 | 0.8213 | NA | NA |
| SRSF2 | bosutinib monohydrate | 0.8216022 | 0.9984574 | 0.8216 | NA | NA |
| EGFR | bosutinib monohydrate | 0.8249647 | 0.9984574 | 0.8250 | NA | NA |
| GNA11 | bosutinib monohydrate | 0.8354619 | 0.9984574 | 0.8355 | NA | NA |
| FGFR3 | bosutinib monohydrate | 0.8529747 | 0.9984574 | 0.8530 | NA | NA |
| CSF3R | bosutinib monohydrate | 0.8534255 | 0.9984574 | 0.8534 | NA | NA |
| FLT3 | bosutinib monohydrate | 0.8695733 | 0.9984574 | 0.8696 | NA | NA |
| PIK3CA | bosutinib monohydrate | 0.8814447 | 0.9984574 | 0.8814 | NA | NA |
| ATM | bosutinib monohydrate | 0.8890563 | 0.9984574 | 0.8891 | NA | NA |
| MYD88 | bosutinib monohydrate | 0.8892270 | 0.9984574 | 0.8892 | NA | NA |
| PIGA | bosutinib monohydrate | 0.8899516 | 0.9984574 | 0.8900 | NA | NA |
| MYCN | bosutinib monohydrate | 0.8946713 | 0.9984574 | 0.8947 | NA | NA |
| AR | bosutinib monohydrate | 0.8991314 | 0.9984574 | 0.8991 | NA | NA |
| ALK | bosutinib monohydrate | 0.9008561 | 0.9984574 | 0.9009 | NA | NA |
| WT1 | bosutinib monohydrate | 0.9087099 | 0.9984574 | 0.9087 | NA | NA |
| HRAS | bosutinib monohydrate | 0.9249674 | 0.9984574 | 0.9250 | NA | NA |
| CALR | bosutinib monohydrate | 0.9357151 | 0.9984574 | 0.9357 | NA | NA |
| CDK4 | bosutinib monohydrate | 0.9416541 | 0.9984574 | 0.9417 | NA | NA |
| FBXW7 | bosutinib monohydrate | 0.9426717 | 0.9984574 | 0.9427 | NA | NA |
| TP53 | bosutinib monohydrate | 0.9456282 | 0.9984574 | 0.9456 | NA | NA |
| NCOA2 | bosutinib monohydrate | 0.9552949 | 0.9984574 | 0.9553 | NA | NA |
| NRAS | bosutinib monohydrate | 0.9617340 | 0.9984574 | 0.9617 | NA | NA |
| RUNX1 | bosutinib monohydrate | 0.9702483 | 0.9984574 | 0.9702 | NA | NA |
| CRLF2 | bosutinib monohydrate | 0.9769377 | 0.9984574 | 0.9769 | NA | NA |
| TPMT | bosutinib monohydrate | 0.9847665 | 0.9984574 | 0.9848 | NA | NA |
| FGFR2 | bosutinib monohydrate | 0.9892432 | 0.9984574 | 0.9892 | NA | NA |
| FLCN | bosutinib monohydrate | 0.9945924 | 0.9984574 | 0.9946 | NA | NA |
| DDIT3 | bosutinib monohydrate | 0.9949740 | 0.9984574 | 0.9950 | NA | NA |
| GATA3 | bosutinib monohydrate | 0.9960502 | 0.9984574 | 0.9961 | NA | NA |
| JAK2 | bosutinib monohydrate | 0.9984574 | 0.9984574 | 0.9985 | NA | NA |
| MYCN | nilotinib | 0.9867686 | 0.9988803 | 0.9868 | NA | NA |
| ALK | nilotinib | 0.9911966 | 0.9988803 | 0.9912 | NA | NA |
| ETV6 | afatinib | 0.9917220 | 0.9994098 | 0.9917 | NA | NA |
| DNMT3A | pazopanib | 0.9995159 | 0.9995159 | 0.9995 | NA | NA |
| NOTCH2 | docetaxel | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| FGFR3 | nilotinib | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| IDH1 | belinostat | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| CTLA4 | rucaparib | 0.9111547 | 1.0000000 | 0.911 | NA | NA |
| SETBP1 | rucaparib | 0.9349068 | 1.0000000 | 0.935 | NA | NA |
| FLCN | rucaparib | 0.9396675 | 1.0000000 | 0.940 | NA | NA |
| ERBB4 | rucaparib | 0.9452339 | 1.0000000 | 0.945 | NA | NA |
| CRLF2 | rucaparib | 0.9477501 | 1.0000000 | 0.948 | NA | NA |
| IKZF1 | rucaparib | 0.9570156 | 1.0000000 | 0.957 | NA | NA |
| BCORL1 | rucaparib | 0.9589124 | 1.0000000 | 0.959 | NA | NA |
| SF1 | rucaparib | 0.9651374 | 1.0000000 | 0.965 | NA | NA |
| PDCD1 | rucaparib | 0.9729859 | 1.0000000 | 0.973 | NA | NA |
| SH2B3 | rucaparib | 0.9811815 | 1.0000000 | 0.981 | NA | NA |
| WT1 | rucaparib | 0.9967317 | 1.0000000 | 0.997 | NA | NA |
| DNAJB1 | rucaparib | 0.9975452 | 1.0000000 | 0.998 | NA | NA |
| CREBBP | rucaparib | 0.9980993 | 1.0000000 | 0.998 | NA | NA |
| EGF | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PHF6 | afatinib | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| ASXL1 | imatinib | 0.8389707 | 1.0000000 | 0.839 | NA | NA |
| JAK2 | imatinib | 0.8521878 | 1.0000000 | 0.852 | NA | NA |
| CDK4 | imatinib | 0.8774107 | 1.0000000 | 0.877 | NA | NA |
| RUNX1 | imatinib | 0.8807874 | 1.0000000 | 0.881 | NA | NA |
| AKT2 | imatinib | 0.9023418 | 1.0000000 | 0.902 | NA | NA |
| NOTCH2 | imatinib | 0.9152305 | 1.0000000 | 0.915 | NA | NA |
| ROS1 | imatinib | 0.9157097 | 1.0000000 | 0.916 | NA | NA |
| SETBP1 | imatinib | 0.9231968 | 1.0000000 | 0.923 | NA | NA |
| PTEN | imatinib | 0.9311434 | 1.0000000 | 0.931 | NA | NA |
| PAX8 | imatinib | 0.9384184 | 1.0000000 | 0.938 | NA | NA |
| CXCR4 | imatinib | 0.9466483 | 1.0000000 | 0.947 | NA | NA |
| MPL | imatinib | 0.9466483 | 1.0000000 | 0.947 | NA | NA |
| ALK | imatinib | 0.9639389 | 1.0000000 | 0.964 | NA | NA |
| CRLF2 | imatinib | 0.9673747 | 1.0000000 | 0.967 | NA | NA |
| FBXW7 | imatinib | 0.9792390 | 1.0000000 | 0.979 | NA | NA |
| PIK3CA | imatinib | 0.9871324 | 1.0000000 | 0.987 | NA | NA |
| PTCH1 | imatinib | 0.9882665 | 1.0000000 | 0.988 | NA | NA |
| CBLB | imatinib | 0.9907752 | 1.0000000 | 0.991 | NA | NA |
| JAK1 | imatinib | 0.9944990 | 1.0000000 | 0.994 | NA | NA |
| MGMT | imatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BCORL1 | erlotinib | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
wilcox_ctrp_gene_lvlA_plot <- ggplot(data = ctrp_signif_lvlA) +
geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_ctrp_gene_lvlA_plot
gdsc_data_ptmuts <- filter(gdsc_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
gdsc_data_ptmuts$Keep_PtMut_Tests <- ifelse(gdsc_data_ptmuts$Reference_Allele_Length == 1 | is.na(gdsc_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(gdsc_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
gdsc_data_ptmuts <- filter(gdsc_data_ptmuts, Keep_PtMut_Tests == TRUE)
gdsc_data_lvlA <- filter(gdsc_data_ptmuts, Hugo_Symbol %in% genes_lvlA)
gdsc_signif_lvlA_ByDrug <- lapply(unique(gdsc_data_lvlA$Drug), WilcoxonByDrug, dataset = gdsc_data_lvlA, data_name = "GDSC")
names(gdsc_signif_lvlA_ByDrug) <- unique(gdsc_data_lvlA$Drug)
saveRDS(gdsc_signif_lvlA_ByDrug, "./data_munging/rds/gdsc_signif_lvlA_ByDrug.rds")
gdsc_signif_lvlA <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = c("Drug", "Hugo_Symbol"), data = gdsc_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
gdsc_signif_lvlA <- adj_signif(gdsc_signif_lvlA)
gdsc_signif_lvlA <- gdsc_signif_lvlA[order(gdsc_signif_lvlA$p),]
saveRDS(gdsc_signif_lvlA, "./data_munging/rds/gdsc_signif_lvlA_gene.rds")
gdsc_signif_lvlA <- readRDS("./data_munging/rds/gdsc_signif_lvlA_gene.rds")
knitr::kable(gdsc_signif_lvlA[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| KRAS | trametinib | 0.0000000 | 0.0000271 | 8.5e-09 | **** | **** |
| BRAF | dabrafenib | 0.0001234 | 0.1668572 | 0.00012 | *** | NA |
| BRAF | trametinib | 0.0001576 | 0.1668572 | 0.00016 | *** | NA |
| PTEN | belinostat | 0.0002105 | 0.1671060 | 0.00021 | *** | NA |
| BCORL1 | temozolomide | 0.0003147 | 0.1999131 | 0.00031 | *** | NA |
| CDKN2A | trametinib | 0.0003927 | 0.1999225 | 0.00039 | *** | NA |
| TP53 | docetaxel | 0.0004703 | 0.1999225 | 0.00047 | *** | NA |
| PDGFRB | cabozantinib | 0.0005036 | 0.1999225 | 0.00050 | *** | NA |
| CDKN2A | docetaxel | 0.0006721 | 0.2371813 | 0.00067 | *** | NA |
| EZH2 | bosutinib monohydrate | 0.0011913 | 0.3783489 | 0.00119 | ** | NA |
| KRAS | palbociclib | 0.0017081 | 0.4931890 | 0.00171 | ** | NA |
| VHL | gefitinib | 0.0020451 | 0.5412812 | 0.00205 | ** | NA |
| PIK3CA | docetaxel | 0.0023604 | 0.5766680 | 0.00236 | ** | NA |
| PDGFRB | tretinoin | 0.0032063 | 0.6922884 | 0.00321 | ** | NA |
| XPO1 | tretinoin | 0.0033296 | 0.6922884 | 0.00333 | ** | NA |
| GNB1 | ruxolitinib | 0.0035419 | 0.6922884 | 0.00354 | ** | NA |
| ROS1 | cabozantinib | 0.0037056 | 0.6922884 | 0.00371 | ** | NA |
| NRAS | imatinib | 0.0040262 | 0.6929219 | 0.00403 | ** | NA |
| GNB1 | alectinib | 0.0042631 | 0.6929219 | 0.00426 | ** | NA |
| KRAS | pazopanib | 0.0043870 | 0.6929219 | 0.00439 | ** | NA |
| NCOA2 | crizotinib | 0.0046821 | 0.6929219 | 0.00468 | ** | NA |
| NOTCH2 | nilotinib | 0.0055404 | 0.6929219 | 0.00554 | ** | NA |
| EGF | gefitinib | 0.0056307 | 0.6929219 | 0.00563 | ** | NA |
| NCOA2 | temozolomide | 0.0057459 | 0.6929219 | 0.00575 | ** | NA |
| VHL | erlotinib | 0.0058080 | 0.6929219 | 0.00581 | ** | NA |
| VHL | lapatinib | 0.0058885 | 0.6929219 | 0.00589 | ** | NA |
| BRCA2 | midostaurin | 0.0058907 | 0.6929219 | 0.00589 | ** | NA |
| NOTCH1 | afatinib | 0.0065209 | 0.7360002 | 0.00652 | ** | NA |
| GNAS | temozolomide | 0.0072122 | 0.7360002 | 0.00721 | ** | NA |
| TSC1 | temozolomide | 0.0073262 | 0.7360002 | 0.00733 | ** | NA |
| NRAS | trametinib | 0.0075575 | 0.7360002 | 0.00756 | ** | NA |
| ABL1 | pazopanib | 0.0076975 | 0.7360002 | 0.00770 | ** | NA |
| CDKN2A | palbociclib | 0.0077157 | 0.7360002 | 0.00772 | ** | NA |
| VHL | afatinib | 0.0079992 | 0.7360002 | 0.00800 | ** | NA |
| CALR | dabrafenib | 0.0081373 | 0.7360002 | 0.00814 | ** | NA |
| NOTCH1 | gefitinib | 0.0083426 | 0.7360002 | 0.00834 | ** | NA |
| ALK | palbociclib | 0.0089754 | 0.7704279 | 0.00898 | ** | NA |
| ETV6 | vismodegib | 0.0097525 | 0.7838930 | 0.00975 | ** | NA |
| SETBP1 | palbociclib | 0.0102198 | 0.7838930 | 0.01022 |
|
NA |
| WHSC1 | temozolomide | 0.0104370 | 0.7838930 | 0.01044 |
|
NA |
| ETV6 | temozolomide | 0.0105755 | 0.7838930 | 0.01058 |
|
NA |
| NOTCH2 | rucaparib | 0.0108793 | 0.7838930 | 0.01088 |
|
NA |
| NOTCH2 | dabrafenib | 0.0122810 | 0.7838930 | 0.01228 |
|
NA |
| XPO1 | dabrafenib | 0.0123840 | 0.7838930 | 0.01238 |
|
NA |
| CREBBP | palbociclib | 0.0129659 | 0.7838930 | 0.01297 |
|
NA |
| RAD21 | nilotinib | 0.0135245 | 0.7838930 | 0.01352 |
|
NA |
| TP53 | palbociclib | 0.0135644 | 0.7838930 | 0.01356 |
|
NA |
| SMC3 | tretinoin | 0.0138983 | 0.7838930 | 0.01390 |
|
NA |
| JAK1 | temozolomide | 0.0139643 | 0.7838930 | 0.01396 |
|
NA |
| NOTCH2 | tretinoin | 0.0152457 | 0.7838930 | 0.01525 |
|
NA |
| NOTCH2 | gefitinib | 0.0154450 | 0.7838930 | 0.01545 |
|
NA |
| PTPN11 | belinostat | 0.0156755 | 0.7838930 | 0.01568 |
|
NA |
| EGF | afatinib | 0.0156979 | 0.7838930 | 0.01570 |
|
NA |
| CDK6 | pazopanib | 0.0157171 | 0.7838930 | 0.01572 |
|
NA |
| AKT3 | docetaxel | 0.0158279 | 0.7838930 | 0.01583 |
|
NA |
| ROS1 | trametinib | 0.0160528 | 0.7838930 | 0.01605 |
|
NA |
| ZRSR2 | tretinoin | 0.0162776 | 0.7838930 | 0.01628 |
|
NA |
| DNMT3A | temozolomide | 0.0163008 | 0.7838930 | 0.01630 |
|
NA |
| FGFR3 | gefitinib | 0.0163800 | 0.7838930 | 0.01638 |
|
NA |
| EZH2 | imatinib | 0.0169779 | 0.7838930 | 0.01698 |
|
NA |
| BRCA1 | tretinoin | 0.0170421 | 0.7838930 | 0.01704 |
|
NA |
| PIK3CA | afatinib | 0.0170969 | 0.7838930 | 0.01710 |
|
NA |
| TP53 | gefitinib | 0.0171497 | 0.7838930 | 0.01715 |
|
NA |
| ERBB2 | afatinib | 0.0171962 | 0.7838930 | 0.01720 |
|
NA |
| CTNNB1 | ruxolitinib | 0.0173719 | 0.7838930 | 0.01737 |
|
NA |
| PTEN | midostaurin | 0.0178005 | 0.7838930 | 0.01780 |
|
NA |
| BRAF | bosutinib monohydrate | 0.0181741 | 0.7838930 | 0.01817 |
|
NA |
| EZH2 | rucaparib | 0.0182099 | 0.7838930 | 0.01821 |
|
NA |
| PAX8 | ruxolitinib | 0.0184880 | 0.7838930 | 0.01849 |
|
NA |
| MAP2K1 | ruxolitinib | 0.0186366 | 0.7838930 | 0.01864 |
|
NA |
| KIT | bosutinib monohydrate | 0.0186703 | 0.7838930 | 0.01867 |
|
NA |
| GNB1 | lapatinib | 0.0188968 | 0.7838930 | 0.01890 |
|
NA |
| ABL1 | gefitinib | 0.0196537 | 0.7838930 | 0.01965 |
|
NA |
| XPO1 | vismodegib | 0.0197148 | 0.7838930 | 0.01971 |
|
NA |
| CDK6 | trametinib | 0.0198135 | 0.7838930 | 0.01981 |
|
NA |
| BRCA2 | erlotinib | 0.0208851 | 0.7838930 | 0.02089 |
|
NA |
| DPYD | lapatinib | 0.0212882 | 0.7838930 | 0.02129 |
|
NA |
| TPMT | cabozantinib | 0.0218657 | 0.7838930 | 0.02187 |
|
NA |
| CTNNB1 | temozolomide | 0.0219771 | 0.7838930 | 0.02198 |
|
NA |
| CDC73 | ponatinib | 0.0223079 | 0.7838930 | 0.02231 |
|
NA |
| SF3B1 | trametinib | 0.0228964 | 0.7838930 | 0.02290 |
|
NA |
| RUNX1 | docetaxel | 0.0229958 | 0.7838930 | 0.02300 |
|
NA |
| NRAS | afatinib | 0.0229960 | 0.7838930 | 0.02300 |
|
NA |
| SH2B3 | cabozantinib | 0.0231792 | 0.7838930 | 0.02318 |
|
NA |
| MGMT | docetaxel | 0.0241785 | 0.7838930 | 0.02418 |
|
NA |
| CREBBP | midostaurin | 0.0242074 | 0.7838930 | 0.02421 |
|
NA |
| CTCF | temozolomide | 0.0242740 | 0.7838930 | 0.02427 |
|
NA |
| GNAQ | vismodegib | 0.0250242 | 0.7838930 | 0.02502 |
|
NA |
| DNAJB1 | cabozantinib | 0.0250495 | 0.7838930 | 0.02505 |
|
NA |
| GNB1 | imatinib | 0.0252224 | 0.7838930 | 0.02522 |
|
NA |
| VHL | temozolomide | 0.0253591 | 0.7838930 | 0.02536 |
|
NA |
| EZH2 | ruxolitinib | 0.0258155 | 0.7838930 | 0.02582 |
|
NA |
| AR | temozolomide | 0.0274000 | 0.7838930 | 0.02740 |
|
NA |
| UGT1A1 | trametinib | 0.0274916 | 0.7838930 | 0.02749 |
|
NA |
| KRAS | dabrafenib | 0.0278924 | 0.7838930 | 0.02789 |
|
NA |
| ETV6 | nilotinib | 0.0280075 | 0.7838930 | 0.02801 |
|
NA |
| GNAQ | temozolomide | 0.0282137 | 0.7838930 | 0.02821 |
|
NA |
| AKT3 | dabrafenib | 0.0282407 | 0.7838930 | 0.02824 |
|
NA |
| GATA2 | trametinib | 0.0282655 | 0.7838930 | 0.02827 |
|
NA |
| FLT3 | cabozantinib | 0.0283979 | 0.7838930 | 0.02840 |
|
NA |
| MAP2K1 | tretinoin | 0.0288016 | 0.7838930 | 0.02880 |
|
NA |
| DNAJB1 | dabrafenib | 0.0289287 | 0.7838930 | 0.02893 |
|
NA |
| CALR | temozolomide | 0.0292063 | 0.7838930 | 0.02921 |
|
NA |
| TET2 | cabozantinib | 0.0296182 | 0.7838930 | 0.02962 |
|
NA |
| TSC1 | sunitinib | 0.0300384 | 0.7838930 | 0.03004 |
|
NA |
| GNAQ | nilotinib | 0.0300494 | 0.7838930 | 0.03005 |
|
NA |
| MAP2K2 | cabozantinib | 0.0302155 | 0.7838930 | 0.03022 |
|
NA |
| PIK3CA | ruxolitinib | 0.0312550 | 0.7838930 | 0.03126 |
|
NA |
| GNAQ | tretinoin | 0.0312954 | 0.7838930 | 0.03130 |
|
NA |
| KMT2A | cabozantinib | 0.0319699 | 0.7838930 | 0.03197 |
|
NA |
| EGF | midostaurin | 0.0320598 | 0.7838930 | 0.03206 |
|
NA |
| AR | tretinoin | 0.0321095 | 0.7838930 | 0.03211 |
|
NA |
| MAP2K1 | nilotinib | 0.0321453 | 0.7838930 | 0.03215 |
|
NA |
| IKZF1 | temozolomide | 0.0321740 | 0.7838930 | 0.03217 |
|
NA |
| CDC73 | nilotinib | 0.0329322 | 0.7838930 | 0.03293 |
|
NA |
| EZH2 | tretinoin | 0.0330076 | 0.7838930 | 0.03301 |
|
NA |
| SMC3 | lapatinib | 0.0337864 | 0.7838930 | 0.03379 |
|
NA |
| ZRSR2 | cabozantinib | 0.0342010 | 0.7838930 | 0.03420 |
|
NA |
| IL7R | temozolomide | 0.0343195 | 0.7838930 | 0.03432 |
|
NA |
| ERBB3 | ponatinib | 0.0344904 | 0.7838930 | 0.03449 |
|
NA |
| GNAS | midostaurin | 0.0345520 | 0.7838930 | 0.03455 |
|
NA |
| DNAJB1 | trametinib | 0.0348374 | 0.7838930 | 0.03484 |
|
NA |
| XPO1 | temozolomide | 0.0353903 | 0.7838930 | 0.03539 |
|
NA |
| NPM1 | tretinoin | 0.0355459 | 0.7838930 | 0.03555 |
|
NA |
| CTNNB1 | docetaxel | 0.0356295 | 0.7838930 | 0.03563 |
|
NA |
| EZH2 | palbociclib | 0.0358492 | 0.7838930 | 0.03585 |
|
NA |
| SF3B1 | sunitinib | 0.0358665 | 0.7838930 | 0.03587 |
|
NA |
| JAK2 | dabrafenib | 0.0362699 | 0.7838930 | 0.03627 |
|
NA |
| CDC73 | vismodegib | 0.0366254 | 0.7838930 | 0.03663 |
|
NA |
| FLT3 | crizotinib | 0.0371049 | 0.7838930 | 0.03710 |
|
NA |
| FBXW7 | gefitinib | 0.0379174 | 0.7838930 | 0.03792 |
|
NA |
| PHF6 | cabozantinib | 0.0380544 | 0.7838930 | 0.03805 |
|
NA |
| FANCL | tretinoin | 0.0383049 | 0.7838930 | 0.03830 |
|
NA |
| UGT1A1 | afatinib | 0.0384529 | 0.7838930 | 0.03845 |
|
NA |
| UGT1A1 | midostaurin | 0.0385592 | 0.7838930 | 0.03856 |
|
NA |
| PIGA | gefitinib | 0.0386253 | 0.7838930 | 0.03863 |
|
NA |
| IDH1 | nilotinib | 0.0386525 | 0.7838930 | 0.03865 |
|
NA |
| ERBB3 | temozolomide | 0.0387034 | 0.7838930 | 0.03870 |
|
NA |
| TP53 | belinostat | 0.0391583 | 0.7838930 | 0.03916 |
|
NA |
| ESR1 | imatinib | 0.0394429 | 0.7838930 | 0.03944 |
|
NA |
| TSC1 | crizotinib | 0.0396633 | 0.7838930 | 0.03966 |
|
NA |
| CDKN2A | afatinib | 0.0397152 | 0.7838930 | 0.03972 |
|
NA |
| U2AF1 | pazopanib | 0.0404444 | 0.7838930 | 0.04044 |
|
NA |
| NOTCH2 | temozolomide | 0.0404672 | 0.7838930 | 0.04047 |
|
NA |
| FGFR2 | docetaxel | 0.0408171 | 0.7838930 | 0.04082 |
|
NA |
| NOTCH1 | trametinib | 0.0408364 | 0.7838930 | 0.04084 |
|
NA |
| BRCA2 | crizotinib | 0.0408902 | 0.7838930 | 0.04089 |
|
NA |
| ZRSR2 | rucaparib | 0.0409566 | 0.7838930 | 0.04096 |
|
NA |
| CREBBP | sunitinib | 0.0413703 | 0.7838930 | 0.04137 |
|
NA |
| TSC1 | tretinoin | 0.0414817 | 0.7838930 | 0.04148 |
|
NA |
| MAP2K2 | rucaparib | 0.0415245 | 0.7838930 | 0.04152 |
|
NA |
| SF3B1 | gefitinib | 0.0415984 | 0.7838930 | 0.04160 |
|
NA |
| EZH2 | temozolomide | 0.0417184 | 0.7838930 | 0.04172 |
|
NA |
| NRAS | belinostat | 0.0419064 | 0.7838930 | 0.04191 |
|
NA |
| CDC73 | tretinoin | 0.0420071 | 0.7838930 | 0.04201 |
|
NA |
| GATA2 | palbociclib | 0.0420214 | 0.7838930 | 0.04202 |
|
NA |
| SETBP1 | cabozantinib | 0.0422020 | 0.7838930 | 0.04220 |
|
NA |
| AKT3 | trametinib | 0.0423852 | 0.7838930 | 0.04239 |
|
NA |
| GNAS | tretinoin | 0.0432305 | 0.7838930 | 0.04323 |
|
NA |
| ABL1 | cabozantinib | 0.0433477 | 0.7838930 | 0.04335 |
|
NA |
| CTNNB1 | cabozantinib | 0.0433564 | 0.7838930 | 0.04336 |
|
NA |
| RAD21 | alectinib | 0.0435161 | 0.7838930 | 0.04352 |
|
NA |
| PDCD1 | temozolomide | 0.0440126 | 0.7838930 | 0.04401 |
|
NA |
| CEBPA | pazopanib | 0.0446243 | 0.7838930 | 0.04462 |
|
NA |
| DNAJB1 | ponatinib | 0.0447942 | 0.7838930 | 0.04479 |
|
NA |
| CDK6 | sunitinib | 0.0453261 | 0.7838930 | 0.04533 |
|
NA |
| ATM | docetaxel | 0.0457127 | 0.7838930 | 0.04571 |
|
NA |
| CREBBP | docetaxel | 0.0462148 | 0.7838930 | 0.04621 |
|
NA |
| NCOA2 | imatinib | 0.0464638 | 0.7838930 | 0.04646 |
|
NA |
| SH2B3 | bosutinib monohydrate | 0.0467380 | 0.7838930 | 0.04674 |
|
NA |
| WHSC1 | ruxolitinib | 0.0467507 | 0.7838930 | 0.04675 |
|
NA |
| DNMT3A | sunitinib | 0.0480660 | 0.7838930 | 0.04807 |
|
NA |
| IDH1 | trametinib | 0.0480714 | 0.7838930 | 0.04807 |
|
NA |
| RAD21 | ruxolitinib | 0.0481399 | 0.7838930 | 0.04814 |
|
NA |
| CRLF2 | docetaxel | 0.0483075 | 0.7838930 | 0.04831 |
|
NA |
| ZRSR2 | trametinib | 0.0485098 | 0.7838930 | 0.04851 |
|
NA |
| SSX1 | temozolomide | 0.0487651 | 0.7838930 | 0.04877 |
|
NA |
| EML4 | alectinib | 0.0492773 | 0.7838930 | 0.04928 |
|
NA |
| GATA3 | palbociclib | 0.0495673 | 0.7838930 | 0.04957 |
|
NA |
| RUNX1 | dasatinib | 0.0499298 | 0.7838930 | 0.04993 |
|
NA |
| TPMT | temozolomide | 0.0503050 | 0.7838930 | 0.05030 | NA | NA |
| TSC1 | rucaparib | 0.0503265 | 0.7838930 | 0.05033 | NA | NA |
| PIK3CA | gefitinib | 0.0505049 | 0.7838930 | 0.05050 | NA | NA |
| NPM1 | dabrafenib | 0.0506987 | 0.7838930 | 0.05070 | NA | NA |
| ABL1 | afatinib | 0.0507264 | 0.7838930 | 0.05073 | NA | NA |
| KIT | nilotinib | 0.0509383 | 0.7838930 | 0.05094 | NA | NA |
| RET | sunitinib | 0.0511239 | 0.7838930 | 0.05112 | NA | NA |
| PAX8 | lapatinib | 0.0512666 | 0.7838930 | 0.05127 | NA | NA |
| GNB1 | pazopanib | 0.0512813 | 0.7838930 | 0.05128 | NA | NA |
| FBXW7 | ponatinib | 0.0514651 | 0.7838930 | 0.05147 | NA | NA |
| ATM | tretinoin | 0.0517302 | 0.7838930 | 0.05173 | NA | NA |
| U2AF1 | palbociclib | 0.0518080 | 0.7838930 | 0.05181 | NA | NA |
| SETBP1 | temozolomide | 0.0526678 | 0.7838930 | 0.05267 | NA | NA |
| SF3B1 | tretinoin | 0.0527261 | 0.7838930 | 0.05273 | NA | NA |
| BCORL1 | ruxolitinib | 0.0528280 | 0.7838930 | 0.05283 | NA | NA |
| CDK6 | afatinib | 0.0547291 | 0.7838930 | 0.05473 | NA | NA |
| EZH2 | cabozantinib | 0.0549646 | 0.7838930 | 0.05496 | NA | NA |
| NCOA2 | ruxolitinib | 0.0550670 | 0.7838930 | 0.05507 | NA | NA |
| FGFR1 | midostaurin | 0.0551905 | 0.7838930 | 0.05519 | NA | NA |
| CALR | trametinib | 0.0553623 | 0.7838930 | 0.05536 | NA | NA |
| EZH2 | lapatinib | 0.0555983 | 0.7838930 | 0.05560 | NA | NA |
| MDM2 | docetaxel | 0.0557127 | 0.7838930 | 0.05571 | NA | NA |
| CBLB | palbociclib | 0.0557547 | 0.7838930 | 0.05575 | NA | NA |
| JAK1 | ruxolitinib | 0.0561915 | 0.7838930 | 0.05619 | NA | NA |
| CTNNB1 | dasatinib | 0.0566920 | 0.7838930 | 0.05669 | NA | NA |
| KMT2A | sunitinib | 0.0567409 | 0.7838930 | 0.05674 | NA | NA |
| CALR | ruxolitinib | 0.0572486 | 0.7838930 | 0.05725 | NA | NA |
| ERBB3 | dabrafenib | 0.0574180 | 0.7838930 | 0.05742 | NA | NA |
| TSC1 | bosutinib monohydrate | 0.0576889 | 0.7838930 | 0.05769 | NA | NA |
| DNMT3A | crizotinib | 0.0577322 | 0.7838930 | 0.05773 | NA | NA |
| TET2 | dabrafenib | 0.0577458 | 0.7838930 | 0.05775 | NA | NA |
| U2AF1 | ruxolitinib | 0.0579826 | 0.7838930 | 0.05798 | NA | NA |
| JAK3 | trametinib | 0.0579978 | 0.7838930 | 0.05800 | NA | NA |
| SETD2 | midostaurin | 0.0586843 | 0.7838930 | 0.05868 | NA | NA |
| BCORL1 | imatinib | 0.0590039 | 0.7838930 | 0.05900 | NA | NA |
| CDKN2A | ruxolitinib | 0.0596793 | 0.7838930 | 0.05968 | NA | NA |
| TP53 | trametinib | 0.0601194 | 0.7838930 | 0.06012 | NA | NA |
| PML | crizotinib | 0.0605225 | 0.7838930 | 0.06052 | NA | NA |
| RET | alectinib | 0.0609957 | 0.7838930 | 0.06100 | NA | NA |
| STAG2 | sunitinib | 0.0614276 | 0.7838930 | 0.06143 | NA | NA |
| TP53 | rucaparib | 0.0614824 | 0.7838930 | 0.06148 | NA | NA |
| ABL1 | ponatinib | 0.0614896 | 0.7838930 | 0.06149 | NA | NA |
| NCOA2 | lapatinib | 0.0614925 | 0.7838930 | 0.06149 | NA | NA |
| PTEN | cabozantinib | 0.0616827 | 0.7838930 | 0.06168 | NA | NA |
| GNAQ | rucaparib | 0.0616841 | 0.7838930 | 0.06168 | NA | NA |
| BCOR | imatinib | 0.0617869 | 0.7838930 | 0.06179 | NA | NA |
| ETV6 | trametinib | 0.0619050 | 0.7838930 | 0.06190 | NA | NA |
| WT1 | erlotinib | 0.0619633 | 0.7838930 | 0.06196 | NA | NA |
| SETBP1 | belinostat | 0.0619635 | 0.7838930 | 0.06196 | NA | NA |
| STAT3 | tretinoin | 0.0621330 | 0.7838930 | 0.06213 | NA | NA |
| PIGA | ponatinib | 0.0621845 | 0.7838930 | 0.06218 | NA | NA |
| EZH2 | vismodegib | 0.0623528 | 0.7838930 | 0.06235 | NA | NA |
| GNB1 | rucaparib | 0.0624029 | 0.7838930 | 0.06240 | NA | NA |
| PDCD1 | trametinib | 0.0627906 | 0.7838930 | 0.06279 | NA | NA |
| JAK3 | imatinib | 0.0632514 | 0.7838930 | 0.06325 | NA | NA |
| WHSC1 | cabozantinib | 0.0636458 | 0.7838930 | 0.06365 | NA | NA |
| PDGFRA | alectinib | 0.0638924 | 0.7838930 | 0.06389 | NA | NA |
| CREBBP | ponatinib | 0.0643029 | 0.7838930 | 0.06430 | NA | NA |
| NCOA2 | pazopanib | 0.0647555 | 0.7838930 | 0.06476 | NA | NA |
| PTCH1 | cabozantinib | 0.0650780 | 0.7838930 | 0.06508 | NA | NA |
| PDGFB | ruxolitinib | 0.0653257 | 0.7838930 | 0.06533 | NA | NA |
| TPMT | belinostat | 0.0656977 | 0.7838930 | 0.06570 | NA | NA |
| GNAQ | docetaxel | 0.0658365 | 0.7838930 | 0.06584 | NA | NA |
| JAK1 | palbociclib | 0.0659376 | 0.7838930 | 0.06594 | NA | NA |
| NRAS | cabozantinib | 0.0660514 | 0.7838930 | 0.06605 | NA | NA |
| ABL1 | ruxolitinib | 0.0661262 | 0.7838930 | 0.06613 | NA | NA |
| EML4 | cabozantinib | 0.0665447 | 0.7838930 | 0.06654 | NA | NA |
| PDGFRB | belinostat | 0.0666829 | 0.7838930 | 0.06668 | NA | NA |
| SETBP1 | alectinib | 0.0668146 | 0.7838930 | 0.06681 | NA | NA |
| VHL | bosutinib monohydrate | 0.0669017 | 0.7838930 | 0.06690 | NA | NA |
| CDK4 | erlotinib | 0.0672825 | 0.7838930 | 0.06728 | NA | NA |
| TET2 | temozolomide | 0.0678581 | 0.7838930 | 0.06786 | NA | NA |
| ZRSR2 | vismodegib | 0.0682009 | 0.7838930 | 0.06820 | NA | NA |
| FGFR3 | temozolomide | 0.0685390 | 0.7838930 | 0.06854 | NA | NA |
| CDKN2A | bosutinib monohydrate | 0.0688711 | 0.7838930 | 0.06887 | NA | NA |
| STAT3 | nilotinib | 0.0689287 | 0.7838930 | 0.06893 | NA | NA |
| CYP19A1 | ruxolitinib | 0.0692408 | 0.7838930 | 0.06924 | NA | NA |
| DNMT3A | docetaxel | 0.0692678 | 0.7838930 | 0.06927 | NA | NA |
| NOTCH2 | pazopanib | 0.0696792 | 0.7838930 | 0.06968 | NA | NA |
| BCORL1 | midostaurin | 0.0699458 | 0.7838930 | 0.06995 | NA | NA |
| RAD21 | cabozantinib | 0.0702610 | 0.7838930 | 0.07026 | NA | NA |
| STAG2 | temozolomide | 0.0703654 | 0.7838930 | 0.07037 | NA | NA |
| CDK4 | vismodegib | 0.0707615 | 0.7838930 | 0.07076 | NA | NA |
| PTPN11 | alectinib | 0.0715010 | 0.7838930 | 0.07150 | NA | NA |
| BRCA2 | lapatinib | 0.0716745 | 0.7838930 | 0.07167 | NA | NA |
| FGFR2 | imatinib | 0.0731536 | 0.7838930 | 0.07315 | NA | NA |
| KIT | trametinib | 0.0733706 | 0.7838930 | 0.07337 | NA | NA |
| CTCF | gefitinib | 0.0736147 | 0.7838930 | 0.07361 | NA | NA |
| TPMT | dabrafenib | 0.0737570 | 0.7838930 | 0.07376 | NA | NA |
| PIK3CA | cabozantinib | 0.0738778 | 0.7838930 | 0.07388 | NA | NA |
| EZH2 | crizotinib | 0.0741267 | 0.7838930 | 0.07413 | NA | NA |
| BRAF | belinostat | 0.0744959 | 0.7838930 | 0.07450 | NA | NA |
| SRSF2 | ponatinib | 0.0749201 | 0.7838930 | 0.07492 | NA | NA |
| IDH1 | dabrafenib | 0.0752645 | 0.7838930 | 0.07526 | NA | NA |
| ZRSR2 | gefitinib | 0.0752776 | 0.7838930 | 0.07528 | NA | NA |
| CDC73 | trametinib | 0.0754663 | 0.7838930 | 0.07547 | NA | NA |
| CSF3R | ponatinib | 0.0758595 | 0.7838930 | 0.07586 | NA | NA |
| PDGFRB | dasatinib | 0.0763115 | 0.7838930 | 0.07631 | NA | NA |
| IL7R | tretinoin | 0.0766084 | 0.7838930 | 0.07661 | NA | NA |
| DPYD | crizotinib | 0.0771266 | 0.7838930 | 0.07713 | NA | NA |
| SMO | temozolomide | 0.0771994 | 0.7838930 | 0.07720 | NA | NA |
| RAD21 | dabrafenib | 0.0773282 | 0.7838930 | 0.07733 | NA | NA |
| GNAS | erlotinib | 0.0775246 | 0.7838930 | 0.07752 | NA | NA |
| TSC1 | nilotinib | 0.0779898 | 0.7838930 | 0.07799 | NA | NA |
| PRPF8 | midostaurin | 0.0781692 | 0.7838930 | 0.07817 | NA | NA |
| ERBB2 | crizotinib | 0.0782120 | 0.7838930 | 0.07821 | NA | NA |
| ALK | gefitinib | 0.0794375 | 0.7838930 | 0.07944 | NA | NA |
| SMC3 | cabozantinib | 0.0794697 | 0.7838930 | 0.07947 | NA | NA |
| CALR | dasatinib | 0.0794829 | 0.7838930 | 0.07948 | NA | NA |
| SRSF2 | palbociclib | 0.0800824 | 0.7838930 | 0.08008 | NA | NA |
| SF3B1 | nilotinib | 0.0801719 | 0.7838930 | 0.08017 | NA | NA |
| ASXL1 | ponatinib | 0.0806503 | 0.7838930 | 0.08065 | NA | NA |
| DNAJB1 | belinostat | 0.0814309 | 0.7838930 | 0.08143 | NA | NA |
| FGFR2 | ponatinib | 0.0814419 | 0.7838930 | 0.08144 | NA | NA |
| DNAJB1 | imatinib | 0.0817584 | 0.7838930 | 0.08176 | NA | NA |
| EGF | palbociclib | 0.0817756 | 0.7838930 | 0.08178 | NA | NA |
| CSF3R | tretinoin | 0.0822956 | 0.7838930 | 0.08230 | NA | NA |
| BTK | palbociclib | 0.0828013 | 0.7838930 | 0.08280 | NA | NA |
| BCOR | belinostat | 0.0836126 | 0.7838930 | 0.08361 | NA | NA |
| CD274 | temozolomide | 0.0837166 | 0.7838930 | 0.08372 | NA | NA |
| PIK3CA | midostaurin | 0.0837587 | 0.7838930 | 0.08376 | NA | NA |
| CTNNB1 | midostaurin | 0.0843253 | 0.7838930 | 0.08433 | NA | NA |
| STAT3 | erlotinib | 0.0845539 | 0.7838930 | 0.08455 | NA | NA |
| FLT3 | erlotinib | 0.0848216 | 0.7838930 | 0.08482 | NA | NA |
| SMO | tretinoin | 0.0848756 | 0.7838930 | 0.08488 | NA | NA |
| RPL10 | cabozantinib | 0.0850440 | 0.7838930 | 0.08504 | NA | NA |
| NT5C2 | alectinib | 0.0850860 | 0.7838930 | 0.08509 | NA | NA |
| STAG2 | belinostat | 0.0851654 | 0.7838930 | 0.08517 | NA | NA |
| CTLA4 | ponatinib | 0.0856420 | 0.7838930 | 0.08564 | NA | NA |
| AKT1 | nilotinib | 0.0856959 | 0.7838930 | 0.08570 | NA | NA |
| FBXW7 | erlotinib | 0.0858748 | 0.7838930 | 0.08587 | NA | NA |
| GNAS | dasatinib | 0.0858809 | 0.7838930 | 0.08588 | NA | NA |
| RPL10 | ponatinib | 0.0860587 | 0.7838930 | 0.08606 | NA | NA |
| SSX1 | rucaparib | 0.0860961 | 0.7838930 | 0.08610 | NA | NA |
| RPL10 | tretinoin | 0.0862479 | 0.7838930 | 0.08625 | NA | NA |
| CDC73 | docetaxel | 0.0864333 | 0.7838930 | 0.08643 | NA | NA |
| EZH2 | alectinib | 0.0868365 | 0.7838930 | 0.08684 | NA | NA |
| RPL10 | alectinib | 0.0868754 | 0.7838930 | 0.08688 | NA | NA |
| RPL10 | midostaurin | 0.0870012 | 0.7838930 | 0.08700 | NA | NA |
| DDIT3 | nilotinib | 0.0871195 | 0.7838930 | 0.08712 | NA | NA |
| RPL10 | afatinib | 0.0872294 | 0.7838930 | 0.08723 | NA | NA |
| MDM2 | imatinib | 0.0872503 | 0.7838930 | 0.08725 | NA | NA |
| RPL10 | palbociclib | 0.0873407 | 0.7838930 | 0.08734 | NA | NA |
| RPL10 | nilotinib | 0.0874302 | 0.7838930 | 0.08743 | NA | NA |
| RUNX1 | vismodegib | 0.0874842 | 0.7838930 | 0.08748 | NA | NA |
| FLCN | ruxolitinib | 0.0877965 | 0.7838930 | 0.08780 | NA | NA |
| RPL10 | crizotinib | 0.0879509 | 0.7838930 | 0.08795 | NA | NA |
| RPL10 | sunitinib | 0.0880602 | 0.7838930 | 0.08806 | NA | NA |
| RPL10 | dasatinib | 0.0880978 | 0.7838930 | 0.08810 | NA | NA |
| PTPN11 | rucaparib | 0.0881492 | 0.7838930 | 0.08815 | NA | NA |
| VHL | imatinib | 0.0884277 | 0.7838930 | 0.08843 | NA | NA |
| CD79B | temozolomide | 0.0884961 | 0.7838930 | 0.08850 | NA | NA |
| RPL10 | ruxolitinib | 0.0887038 | 0.7838930 | 0.08870 | NA | NA |
| PDGFRB | midostaurin | 0.0887296 | 0.7838930 | 0.08873 | NA | NA |
| VHL | rucaparib | 0.0888741 | 0.7838930 | 0.08887 | NA | NA |
| RPL10 | vismodegib | 0.0892587 | 0.7838930 | 0.08926 | NA | NA |
| NCOA2 | vismodegib | 0.0893861 | 0.7838930 | 0.08939 | NA | NA |
| JAK2 | trametinib | 0.0900127 | 0.7838930 | 0.09001 | NA | NA |
| WT1 | sunitinib | 0.0903271 | 0.7838930 | 0.09033 | NA | NA |
| PTEN | docetaxel | 0.0903770 | 0.7838930 | 0.09038 | NA | NA |
| WHSC1 | docetaxel | 0.0905119 | 0.7838930 | 0.09051 | NA | NA |
| FGFR2 | erlotinib | 0.0905151 | 0.7838930 | 0.09052 | NA | NA |
| SRSF2 | midostaurin | 0.0908838 | 0.7838930 | 0.09088 | NA | NA |
| UGT1A1 | tretinoin | 0.0911112 | 0.7838930 | 0.09111 | NA | NA |
| RPL10 | erlotinib | 0.0912646 | 0.7838930 | 0.09126 | NA | NA |
| FBXW7 | cabozantinib | 0.0914621 | 0.7838930 | 0.09146 | NA | NA |
| BRCA2 | tretinoin | 0.0916313 | 0.7838930 | 0.09163 | NA | NA |
| ABL1 | docetaxel | 0.0918631 | 0.7838930 | 0.09186 | NA | NA |
| CBLB | docetaxel | 0.0924219 | 0.7838930 | 0.09242 | NA | NA |
| FLCN | crizotinib | 0.0928500 | 0.7838930 | 0.09285 | NA | NA |
| CALR | ponatinib | 0.0929099 | 0.7838930 | 0.09291 | NA | NA |
| AR | dasatinib | 0.0930278 | 0.7838930 | 0.09303 | NA | NA |
| BRCA2 | dasatinib | 0.0931223 | 0.7838930 | 0.09312 | NA | NA |
| CD274 | belinostat | 0.0932739 | 0.7838930 | 0.09327 | NA | NA |
| CTLA4 | cabozantinib | 0.0933469 | 0.7838930 | 0.09335 | NA | NA |
| IDH2 | cabozantinib | 0.0934140 | 0.7838930 | 0.09341 | NA | NA |
| SH2B3 | vismodegib | 0.0934678 | 0.7838930 | 0.09347 | NA | NA |
| TPMT | alectinib | 0.0935866 | 0.7838930 | 0.09359 | NA | NA |
| PTEN | rucaparib | 0.0938970 | 0.7838930 | 0.09390 | NA | NA |
| ROS1 | erlotinib | 0.0943399 | 0.7838930 | 0.09434 | NA | NA |
| CD274 | alectinib | 0.0945006 | 0.7838930 | 0.09450 | NA | NA |
| EML4 | imatinib | 0.0947179 | 0.7838930 | 0.09472 | NA | NA |
| GNB1 | crizotinib | 0.0953243 | 0.7838930 | 0.09532 | NA | NA |
| RPL10 | imatinib | 0.0953332 | 0.7838930 | 0.09533 | NA | NA |
| MYD88 | ruxolitinib | 0.0954788 | 0.7838930 | 0.09548 | NA | NA |
| NPM1 | dasatinib | 0.0957018 | 0.7838930 | 0.09570 | NA | NA |
| TPMT | tretinoin | 0.0957413 | 0.7838930 | 0.09574 | NA | NA |
| RPL10 | lapatinib | 0.0958239 | 0.7838930 | 0.09582 | NA | NA |
| CALR | pazopanib | 0.0961360 | 0.7838930 | 0.09614 | NA | NA |
| SETBP1 | trametinib | 0.0962877 | 0.7838930 | 0.09629 | NA | NA |
| WT1 | midostaurin | 0.0964995 | 0.7838930 | 0.09650 | NA | NA |
| PRPF40B | temozolomide | 0.0965946 | 0.7838930 | 0.09659 | NA | NA |
| CBL | afatinib | 0.0971709 | 0.7838930 | 0.09717 | NA | NA |
| IL7R | ponatinib | 0.0972285 | 0.7838930 | 0.09723 | NA | NA |
| MET | lapatinib | 0.0972319 | 0.7838930 | 0.09723 | NA | NA |
| DNMT3A | rucaparib | 0.0975186 | 0.7838930 | 0.09752 | NA | NA |
| NOTCH1 | temozolomide | 0.0980228 | 0.7838930 | 0.09802 | NA | NA |
| TET2 | vismodegib | 0.0981762 | 0.7838930 | 0.09818 | NA | NA |
| RET | palbociclib | 0.0983382 | 0.7838930 | 0.09834 | NA | NA |
| SMC3 | temozolomide | 0.0984456 | 0.7838930 | 0.09845 | NA | NA |
| FGFR2 | trametinib | 0.0984897 | 0.7838930 | 0.09849 | NA | NA |
| FLCN | lapatinib | 0.0985096 | 0.7838930 | 0.09851 | NA | NA |
| AKT3 | alectinib | 0.0987542 | 0.7838930 | 0.09875 | NA | NA |
| MAP2K1 | temozolomide | 0.0987836 | 0.7838930 | 0.09878 | NA | NA |
| ERBB2 | gefitinib | 0.0989296 | 0.7838930 | 0.09893 | NA | NA |
| FLT3 | imatinib | 0.0990080 | 0.7838930 | 0.09901 | NA | NA |
| CTLA4 | tretinoin | 0.0990569 | 0.7838930 | 0.09906 | NA | NA |
| JAK1 | cabozantinib | 0.0992758 | 0.7838930 | 0.09928 | NA | NA |
| CTLA4 | bosutinib monohydrate | 0.0999893 | 0.7838930 | 0.09999 | NA | NA |
| PRPF8 | pazopanib | 0.1000832 | 0.7838930 | 0.10008 | NA | NA |
| BTK | bosutinib monohydrate | 0.1001931 | 0.7838930 | 0.10019 | NA | NA |
| WT1 | trametinib | 0.1003839 | 0.7838930 | 0.10038 | NA | NA |
| JAK2 | cabozantinib | 0.1004191 | 0.7838930 | 0.10042 | NA | NA |
| NT5C2 | dabrafenib | 0.1005154 | 0.7838930 | 0.10052 | NA | NA |
| FLCN | imatinib | 0.1005378 | 0.7838930 | 0.10054 | NA | NA |
| RUNX1 | lapatinib | 0.1014759 | 0.7838930 | 0.10148 | NA | NA |
| XPO1 | trametinib | 0.1015015 | 0.7838930 | 0.10150 | NA | NA |
| MYCN | tretinoin | 0.1019536 | 0.7838930 | 0.10195 | NA | NA |
| GNB1 | dasatinib | 0.1021196 | 0.7838930 | 0.10212 | NA | NA |
| ETV6 | tretinoin | 0.1021380 | 0.7838930 | 0.10214 | NA | NA |
| SH2B3 | ponatinib | 0.1023151 | 0.7838930 | 0.10232 | NA | NA |
| BRCA2 | palbociclib | 0.1027690 | 0.7838930 | 0.10277 | NA | NA |
| GNA11 | pazopanib | 0.1031129 | 0.7838930 | 0.10311 | NA | NA |
| RPL10 | gefitinib | 0.1035789 | 0.7838930 | 0.10358 | NA | NA |
| PTEN | tretinoin | 0.1038671 | 0.7838930 | 0.10387 | NA | NA |
| ZRSR2 | palbociclib | 0.1039936 | 0.7838930 | 0.10399 | NA | NA |
| SETBP1 | crizotinib | 0.1040172 | 0.7838930 | 0.10402 | NA | NA |
| MYD88 | trametinib | 0.1042757 | 0.7838930 | 0.10428 | NA | NA |
| BCOR | midostaurin | 0.1045093 | 0.7838930 | 0.10451 | NA | NA |
| MAP2K2 | bosutinib monohydrate | 0.1046536 | 0.7838930 | 0.10465 | NA | NA |
| PML | midostaurin | 0.1046555 | 0.7838930 | 0.10466 | NA | NA |
| SMC3 | dasatinib | 0.1047138 | 0.7838930 | 0.10471 | NA | NA |
| PAX8 | docetaxel | 0.1054555 | 0.7838930 | 0.10546 | NA | NA |
| DNAJB1 | nilotinib | 0.1060679 | 0.7838930 | 0.10607 | NA | NA |
| TSC2 | tretinoin | 0.1061419 | 0.7838930 | 0.10614 | NA | NA |
| CXCR4 | gefitinib | 0.1064188 | 0.7838930 | 0.10642 | NA | NA |
| AKT3 | dasatinib | 0.1068213 | 0.7838930 | 0.10682 | NA | NA |
| CTLA4 | vismodegib | 0.1069540 | 0.7838930 | 0.10695 | NA | NA |
| EED | pazopanib | 0.1069880 | 0.7838930 | 0.10699 | NA | NA |
| ABL1 | trametinib | 0.1069974 | 0.7838930 | 0.10700 | NA | NA |
| TET2 | nilotinib | 0.1073900 | 0.7838930 | 0.10739 | NA | NA |
| PDGFRA | gefitinib | 0.1077698 | 0.7838930 | 0.10777 | NA | NA |
| XPO1 | nilotinib | 0.1080468 | 0.7838930 | 0.10805 | NA | NA |
| CYP19A1 | imatinib | 0.1086620 | 0.7838930 | 0.10866 | NA | NA |
| PHF6 | dabrafenib | 0.1087549 | 0.7838930 | 0.10875 | NA | NA |
| U2AF1 | docetaxel | 0.1088557 | 0.7838930 | 0.10886 | NA | NA |
| CRLF2 | erlotinib | 0.1091200 | 0.7838930 | 0.10912 | NA | NA |
| BCORL1 | belinostat | 0.1094027 | 0.7838930 | 0.10940 | NA | NA |
| CBL | lapatinib | 0.1099732 | 0.7838930 | 0.10997 | NA | NA |
| CD274 | cabozantinib | 0.1100504 | 0.7838930 | 0.11005 | NA | NA |
| ERBB3 | midostaurin | 0.1104412 | 0.7838930 | 0.11044 | NA | NA |
| MDM2 | rucaparib | 0.1105299 | 0.7838930 | 0.11053 | NA | NA |
| CXCR4 | ponatinib | 0.1109241 | 0.7838930 | 0.11092 | NA | NA |
| SMC3 | alectinib | 0.1109591 | 0.7838930 | 0.11096 | NA | NA |
| FLCN | alectinib | 0.1110717 | 0.7838930 | 0.11107 | NA | NA |
| TP53 | afatinib | 0.1112751 | 0.7838930 | 0.11128 | NA | NA |
| TSC2 | dabrafenib | 0.1118016 | 0.7838930 | 0.11180 | NA | NA |
| PAX5 | sunitinib | 0.1124728 | 0.7838930 | 0.11247 | NA | NA |
| RUNX1 | tretinoin | 0.1125899 | 0.7838930 | 0.11259 | NA | NA |
| AKT3 | pazopanib | 0.1128443 | 0.7838930 | 0.11284 | NA | NA |
| CBL | dabrafenib | 0.1130546 | 0.7838930 | 0.11305 | NA | NA |
| BRAF | palbociclib | 0.1131136 | 0.7838930 | 0.11311 | NA | NA |
| FGFR2 | cabozantinib | 0.1132666 | 0.7838930 | 0.11327 | NA | NA |
| ROS1 | tretinoin | 0.1136424 | 0.7838930 | 0.11364 | NA | NA |
| CRLF2 | lapatinib | 0.1138543 | 0.7838930 | 0.11385 | NA | NA |
| SETD2 | dabrafenib | 0.1138566 | 0.7838930 | 0.11386 | NA | NA |
| PRPF40B | erlotinib | 0.1140652 | 0.7838930 | 0.11407 | NA | NA |
| MDM2 | cabozantinib | 0.1141686 | 0.7838930 | 0.11417 | NA | NA |
| STAT3 | ponatinib | 0.1142358 | 0.7838930 | 0.11424 | NA | NA |
| SRSF2 | gefitinib | 0.1142775 | 0.7838930 | 0.11428 | NA | NA |
| ROS1 | ponatinib | 0.1143242 | 0.7838930 | 0.11432 | NA | NA |
| FANCL | vismodegib | 0.1143467 | 0.7838930 | 0.11435 | NA | NA |
| CREBBP | dasatinib | 0.1144672 | 0.7838930 | 0.11447 | NA | NA |
| AKT2 | temozolomide | 0.1148997 | 0.7838930 | 0.11490 | NA | NA |
| ESR1 | temozolomide | 0.1154649 | 0.7838930 | 0.11546 | NA | NA |
| ATM | dabrafenib | 0.1159223 | 0.7838930 | 0.11592 | NA | NA |
| G6PD | bosutinib monohydrate | 0.1162560 | 0.7838930 | 0.11626 | NA | NA |
| FGFR1 | palbociclib | 0.1164096 | 0.7838930 | 0.11641 | NA | NA |
| NRAS | lapatinib | 0.1166057 | 0.7838930 | 0.11661 | NA | NA |
| STAT3 | vismodegib | 0.1166536 | 0.7838930 | 0.11665 | NA | NA |
| GATA1 | gefitinib | 0.1169619 | 0.7838930 | 0.11696 | NA | NA |
| FANCL | ponatinib | 0.1174239 | 0.7838930 | 0.11742 | NA | NA |
| BRCA2 | imatinib | 0.1174800 | 0.7838930 | 0.11748 | NA | NA |
| XPO1 | crizotinib | 0.1179406 | 0.7838930 | 0.11794 | NA | NA |
| ETV6 | pazopanib | 0.1180629 | 0.7838930 | 0.11806 | NA | NA |
| GATA3 | crizotinib | 0.1184833 | 0.7838930 | 0.11848 | NA | NA |
| CBL | erlotinib | 0.1192013 | 0.7838930 | 0.11920 | NA | NA |
| EZH2 | ponatinib | 0.1193818 | 0.7838930 | 0.11938 | NA | NA |
| VHL | palbociclib | 0.1197067 | 0.7838930 | 0.11971 | NA | NA |
| CTLA4 | nilotinib | 0.1201225 | 0.7838930 | 0.12012 | NA | NA |
| PAX5 | ruxolitinib | 0.1202681 | 0.7838930 | 0.12027 | NA | NA |
| RPL10 | docetaxel | 0.1206554 | 0.7838930 | 0.12066 | NA | NA |
| SMO | docetaxel | 0.1208460 | 0.7838930 | 0.12085 | NA | NA |
| MDM2 | crizotinib | 0.1214898 | 0.7838930 | 0.12149 | NA | NA |
| BTK | pazopanib | 0.1215251 | 0.7838930 | 0.12153 | NA | NA |
| PDGFRA | tretinoin | 0.1216752 | 0.7838930 | 0.12168 | NA | NA |
| CDK6 | ponatinib | 0.1216781 | 0.7838930 | 0.12168 | NA | NA |
| RPL10 | bosutinib monohydrate | 0.1218958 | 0.7838930 | 0.12190 | NA | NA |
| PIK3CA | rucaparib | 0.1220643 | 0.7838930 | 0.12206 | NA | NA |
| KMT2A | palbociclib | 0.1221128 | 0.7838930 | 0.12211 | NA | NA |
| NCOA2 | belinostat | 0.1222655 | 0.7838930 | 0.12227 | NA | NA |
| XPO1 | afatinib | 0.1226343 | 0.7838930 | 0.12263 | NA | NA |
| MGMT | afatinib | 0.1228036 | 0.7838930 | 0.12280 | NA | NA |
| ERBB2 | lapatinib | 0.1230985 | 0.7838930 | 0.12310 | NA | NA |
| EED | rucaparib | 0.1231156 | 0.7838930 | 0.12312 | NA | NA |
| TPMT | ruxolitinib | 0.1231531 | 0.7838930 | 0.12315 | NA | NA |
| ERBB2 | midostaurin | 0.1231748 | 0.7838930 | 0.12317 | NA | NA |
| IDH2 | belinostat | 0.1232427 | 0.7838930 | 0.12324 | NA | NA |
| PIGA | imatinib | 0.1236551 | 0.7838930 | 0.12366 | NA | NA |
| RIT1 | imatinib | 0.1236551 | 0.7838930 | 0.12366 | NA | NA |
| SMC1A | imatinib | 0.1238297 | 0.7838930 | 0.12383 | NA | NA |
| PAX5 | cabozantinib | 0.1242237 | 0.7838930 | 0.12422 | NA | NA |
| CDK6 | crizotinib | 0.1242377 | 0.7838930 | 0.12424 | NA | NA |
| GATA3 | lapatinib | 0.1247292 | 0.7838930 | 0.12473 | NA | NA |
| FANCL | alectinib | 0.1248849 | 0.7838930 | 0.12488 | NA | NA |
| KIT | tretinoin | 0.1249785 | 0.7838930 | 0.12498 | NA | NA |
| GNB1 | trametinib | 0.1250888 | 0.7838930 | 0.12509 | NA | NA |
| UGT1A1 | bosutinib monohydrate | 0.1252560 | 0.7838930 | 0.12526 | NA | NA |
| MAP2K2 | belinostat | 0.1254344 | 0.7838930 | 0.12543 | NA | NA |
| ALK | dabrafenib | 0.1254923 | 0.7838930 | 0.12549 | NA | NA |
| VHL | belinostat | 0.1257218 | 0.7838930 | 0.12572 | NA | NA |
| MYD88 | docetaxel | 0.1258052 | 0.7838930 | 0.12581 | NA | NA |
| CDKN2A | ponatinib | 0.1262284 | 0.7838930 | 0.12623 | NA | NA |
| NRAS | gefitinib | 0.1262378 | 0.7838930 | 0.12624 | NA | NA |
| MGMT | gefitinib | 0.1263998 | 0.7838930 | 0.12640 | NA | NA |
| PTCH1 | midostaurin | 0.1266216 | 0.7838930 | 0.12662 | NA | NA |
| NCOA2 | tretinoin | 0.1266814 | 0.7838930 | 0.12668 | NA | NA |
| RUNX1 | ruxolitinib | 0.1276182 | 0.7838930 | 0.12762 | NA | NA |
| CBLB | dasatinib | 0.1279141 | 0.7838930 | 0.12791 | NA | NA |
| MET | erlotinib | 0.1281272 | 0.7838930 | 0.12813 | NA | NA |
| FLCN | sunitinib | 0.1281801 | 0.7838930 | 0.12818 | NA | NA |
| SETD2 | alectinib | 0.1283291 | 0.7838930 | 0.12833 | NA | NA |
| CBL | sunitinib | 0.1283819 | 0.7838930 | 0.12838 | NA | NA |
| MGMT | erlotinib | 0.1288089 | 0.7838930 | 0.12881 | NA | NA |
| FGFR1 | trametinib | 0.1292149 | 0.7838930 | 0.12921 | NA | NA |
| KMT2A | belinostat | 0.1296916 | 0.7838930 | 0.12969 | NA | NA |
| GNA11 | ponatinib | 0.1297896 | 0.7838930 | 0.12979 | NA | NA |
| MET | crizotinib | 0.1305419 | 0.7838930 | 0.13054 | NA | NA |
| NOTCH1 | rucaparib | 0.1306394 | 0.7838930 | 0.13064 | NA | NA |
| MAP2K1 | alectinib | 0.1306584 | 0.7838930 | 0.13066 | NA | NA |
| ERBB2 | temozolomide | 0.1311049 | 0.7838930 | 0.13110 | NA | NA |
| IDH2 | temozolomide | 0.1311580 | 0.7838930 | 0.13116 | NA | NA |
| NOTCH2 | afatinib | 0.1313985 | 0.7838930 | 0.13140 | NA | NA |
| ATM | crizotinib | 0.1315741 | 0.7838930 | 0.13157 | NA | NA |
| FLCN | pazopanib | 0.1317962 | 0.7838930 | 0.13180 | NA | NA |
| GATA1 | afatinib | 0.1322836 | 0.7838930 | 0.13228 | NA | NA |
| TSC2 | nilotinib | 0.1328358 | 0.7838930 | 0.13284 | NA | NA |
| ETV6 | imatinib | 0.1331229 | 0.7838930 | 0.13312 | NA | NA |
| PDGFRA | afatinib | 0.1332170 | 0.7838930 | 0.13322 | NA | NA |
| NT5C2 | palbociclib | 0.1332752 | 0.7838930 | 0.13328 | NA | NA |
| FLCN | erlotinib | 0.1333236 | 0.7838930 | 0.13332 | NA | NA |
| TP53 | cabozantinib | 0.1336110 | 0.7838930 | 0.13361 | NA | NA |
| JAK3 | nilotinib | 0.1339154 | 0.7838930 | 0.13392 | NA | NA |
| CALR | erlotinib | 0.1340397 | 0.7838930 | 0.13404 | NA | NA |
| JAK3 | rucaparib | 0.1342473 | 0.7838930 | 0.13425 | NA | NA |
| PTCH1 | gefitinib | 0.1346354 | 0.7838930 | 0.13464 | NA | NA |
| PDGFRA | nilotinib | 0.1346957 | 0.7838930 | 0.13470 | NA | NA |
| MET | belinostat | 0.1348014 | 0.7838930 | 0.13480 | NA | NA |
| EGFR | dabrafenib | 0.1350723 | 0.7838930 | 0.13507 | NA | NA |
| PDGFRA | trametinib | 0.1350935 | 0.7838930 | 0.13509 | NA | NA |
| JAK3 | ruxolitinib | 0.1351891 | 0.7838930 | 0.13519 | NA | NA |
| EED | temozolomide | 0.1353524 | 0.7838930 | 0.13535 | NA | NA |
| RIT1 | dasatinib | 0.1353958 | 0.7838930 | 0.13540 | NA | NA |
| PTPN11 | cabozantinib | 0.1354785 | 0.7838930 | 0.13548 | NA | NA |
| SMC1A | dasatinib | 0.1356364 | 0.7838930 | 0.13564 | NA | NA |
| MET | dabrafenib | 0.1361932 | 0.7838930 | 0.13619 | NA | NA |
| CREBBP | gefitinib | 0.1371167 | 0.7838930 | 0.13712 | NA | NA |
| TP53 | dabrafenib | 0.1373973 | 0.7838930 | 0.13740 | NA | NA |
| GNAS | ponatinib | 0.1378710 | 0.7838930 | 0.13787 | NA | NA |
| CDKN2A | rucaparib | 0.1382694 | 0.7838930 | 0.13827 | NA | NA |
| ASXL1 | alectinib | 0.1383344 | 0.7838930 | 0.13833 | NA | NA |
| JAK2 | vismodegib | 0.1385135 | 0.7838930 | 0.13851 | NA | NA |
| ALK | trametinib | 0.1385711 | 0.7838930 | 0.13857 | NA | NA |
| GNB1 | temozolomide | 0.1386197 | 0.7838930 | 0.13862 | NA | NA |
| RAD21 | vismodegib | 0.1386885 | 0.7838930 | 0.13869 | NA | NA |
| TSC2 | trametinib | 0.1392327 | 0.7838930 | 0.13923 | NA | NA |
| CDK4 | sunitinib | 0.1393853 | 0.7838930 | 0.13939 | NA | NA |
| PAX8 | erlotinib | 0.1394332 | 0.7838930 | 0.13943 | NA | NA |
| MPL | nilotinib | 0.1396520 | 0.7838930 | 0.13965 | NA | NA |
| CBL | crizotinib | 0.1406039 | 0.7838930 | 0.14060 | NA | NA |
| PDGFRA | cabozantinib | 0.1407290 | 0.7838930 | 0.14073 | NA | NA |
| EED | alectinib | 0.1407867 | 0.7838930 | 0.14079 | NA | NA |
| ATM | midostaurin | 0.1408355 | 0.7838930 | 0.14084 | NA | NA |
| UGT1A1 | lapatinib | 0.1409522 | 0.7838930 | 0.14095 | NA | NA |
| BRAF | rucaparib | 0.1413053 | 0.7838930 | 0.14131 | NA | NA |
| GNAQ | alectinib | 0.1418350 | 0.7838930 | 0.14183 | NA | NA |
| CDC73 | temozolomide | 0.1419861 | 0.7838930 | 0.14199 | NA | NA |
| AKT1 | midostaurin | 0.1419954 | 0.7838930 | 0.14200 | NA | NA |
| FGFR1 | erlotinib | 0.1424666 | 0.7838930 | 0.14247 | NA | NA |
| RIT1 | rucaparib | 0.1426020 | 0.7838930 | 0.14260 | NA | NA |
| STAT3 | ruxolitinib | 0.1427439 | 0.7838930 | 0.14274 | NA | NA |
| WHSC1 | dasatinib | 0.1428838 | 0.7838930 | 0.14288 | NA | NA |
| ALK | lapatinib | 0.1428928 | 0.7838930 | 0.14289 | NA | NA |
| MAP2K1 | imatinib | 0.1429961 | 0.7838930 | 0.14300 | NA | NA |
| KIT | cabozantinib | 0.1434514 | 0.7838930 | 0.14345 | NA | NA |
| KRAS | cabozantinib | 0.1437272 | 0.7838930 | 0.14373 | NA | NA |
| FGFR3 | afatinib | 0.1440811 | 0.7838930 | 0.14408 | NA | NA |
| DNAJB1 | sunitinib | 0.1441839 | 0.7838930 | 0.14418 | NA | NA |
| GATA2 | bosutinib monohydrate | 0.1441992 | 0.7838930 | 0.14420 | NA | NA |
| MAP2K1 | afatinib | 0.1443384 | 0.7838930 | 0.14434 | NA | NA |
| GATA3 | trametinib | 0.1446868 | 0.7838930 | 0.14469 | NA | NA |
| PDGFB | erlotinib | 0.1449924 | 0.7838930 | 0.14499 | NA | NA |
| CBL | belinostat | 0.1450619 | 0.7838930 | 0.14506 | NA | NA |
| MAP2K2 | palbociclib | 0.1451389 | 0.7838930 | 0.14514 | NA | NA |
| ERBB3 | imatinib | 0.1453832 | 0.7838930 | 0.14538 | NA | NA |
| CTNNB1 | nilotinib | 0.1455938 | 0.7838930 | 0.14559 | NA | NA |
| NOTCH1 | lapatinib | 0.1462669 | 0.7838930 | 0.14627 | NA | NA |
| CBL | dasatinib | 0.1464269 | 0.7838930 | 0.14643 | NA | NA |
| PRPF8 | rucaparib | 0.1466626 | 0.7838930 | 0.14666 | NA | NA |
| CTLA4 | alectinib | 0.1466805 | 0.7838930 | 0.14668 | NA | NA |
| RUNX1 | sunitinib | 0.1467646 | 0.7838930 | 0.14676 | NA | NA |
| UGT1A1 | erlotinib | 0.1468898 | 0.7838930 | 0.14689 | NA | NA |
| EGF | imatinib | 0.1470992 | 0.7838930 | 0.14710 | NA | NA |
| FANCL | imatinib | 0.1471141 | 0.7838930 | 0.14711 | NA | NA |
| RET | docetaxel | 0.1477981 | 0.7838930 | 0.14780 | NA | NA |
| IL7R | rucaparib | 0.1489089 | 0.7838930 | 0.14891 | NA | NA |
| BCOR | cabozantinib | 0.1489401 | 0.7838930 | 0.14894 | NA | NA |
| CRLF2 | cabozantinib | 0.1490076 | 0.7838930 | 0.14901 | NA | NA |
| G6PD | alectinib | 0.1491983 | 0.7838930 | 0.14920 | NA | NA |
| EZH2 | afatinib | 0.1496126 | 0.7838930 | 0.14961 | NA | NA |
| NPM1 | belinostat | 0.1498150 | 0.7838930 | 0.14982 | NA | NA |
| IL7R | trametinib | 0.1502552 | 0.7838930 | 0.15026 | NA | NA |
| IDH2 | rucaparib | 0.1502920 | 0.7838930 | 0.15029 | NA | NA |
| SF1 | belinostat | 0.1506532 | 0.7838930 | 0.15065 | NA | NA |
| ERBB4 | cabozantinib | 0.1509455 | 0.7838930 | 0.15095 | NA | NA |
| MET | imatinib | 0.1511805 | 0.7838930 | 0.15118 | NA | NA |
| RPL10 | pazopanib | 0.1515056 | 0.7838930 | 0.15151 | NA | NA |
| CDC73 | dabrafenib | 0.1516303 | 0.7838930 | 0.15163 | NA | NA |
| AKT1 | bosutinib monohydrate | 0.1516806 | 0.7838930 | 0.15168 | NA | NA |
| FGFR1 | ruxolitinib | 0.1519639 | 0.7838930 | 0.15196 | NA | NA |
| CRLF2 | dabrafenib | 0.1520171 | 0.7838930 | 0.15202 | NA | NA |
| ZRSR2 | ruxolitinib | 0.1522656 | 0.7838930 | 0.15227 | NA | NA |
| BRAF | alectinib | 0.1526449 | 0.7838930 | 0.15264 | NA | NA |
| CALR | nilotinib | 0.1528002 | 0.7838930 | 0.15280 | NA | NA |
| PRPF40B | ruxolitinib | 0.1533423 | 0.7838930 | 0.15334 | NA | NA |
| CTCF | docetaxel | 0.1533534 | 0.7838930 | 0.15335 | NA | NA |
| XPO1 | dasatinib | 0.1535899 | 0.7838930 | 0.15359 | NA | NA |
| FLT3 | nilotinib | 0.1535908 | 0.7838930 | 0.15359 | NA | NA |
| IKZF1 | ruxolitinib | 0.1536440 | 0.7838930 | 0.15364 | NA | NA |
| PTPN11 | ponatinib | 0.1536929 | 0.7838930 | 0.15369 | NA | NA |
| EZH2 | nilotinib | 0.1537478 | 0.7838930 | 0.15375 | NA | NA |
| PRPF8 | temozolomide | 0.1540934 | 0.7838930 | 0.15409 | NA | NA |
| IL7R | ruxolitinib | 0.1543734 | 0.7838930 | 0.15437 | NA | NA |
| WHSC1 | vismodegib | 0.1543822 | 0.7838930 | 0.15438 | NA | NA |
| PDCD1 | dabrafenib | 0.1546264 | 0.7838930 | 0.15463 | NA | NA |
| ATM | erlotinib | 0.1547223 | 0.7838930 | 0.15472 | NA | NA |
| GNAQ | trametinib | 0.1547547 | 0.7838930 | 0.15475 | NA | NA |
| FGFR3 | erlotinib | 0.1556510 | 0.7867938 | 0.15565 | NA | NA |
| IL7R | alectinib | 0.1558610 | 0.7867938 | 0.15586 | NA | NA |
| IKZF1 | dasatinib | 0.1560706 | 0.7867938 | 0.15607 | NA | NA |
| PTEN | ruxolitinib | 0.1566767 | 0.7885977 | 0.15668 | NA | NA |
| WHSC1 | trametinib | 0.1570917 | 0.7894353 | 0.15709 | NA | NA |
| NRAS | pazopanib | 0.1573839 | 0.7896543 | 0.15738 | NA | NA |
| AKT3 | midostaurin | 0.1590833 | 0.7957730 | 0.15908 | NA | NA |
| ZRSR2 | dabrafenib | 0.1591476 | 0.7957730 | 0.15915 | NA | NA |
| TSC2 | afatinib | 0.1594651 | 0.7957730 | 0.15947 | NA | NA |
| CD79B | dabrafenib | 0.1596056 | 0.7957730 | 0.15961 | NA | NA |
| ERBB4 | gefitinib | 0.1599159 | 0.7960703 | 0.15992 | NA | NA |
| RIT1 | sunitinib | 0.1606843 | 0.7970975 | 0.16068 | NA | NA |
| CREBBP | pazopanib | 0.1610486 | 0.7970975 | 0.16105 | NA | NA |
| SMC1A | sunitinib | 0.1610595 | 0.7970975 | 0.16106 | NA | NA |
| CALR | midostaurin | 0.1612397 | 0.7970975 | 0.16124 | NA | NA |
| HRAS | palbociclib | 0.1615122 | 0.7970975 | 0.16151 | NA | NA |
| MAP2K1 | vismodegib | 0.1617145 | 0.7970975 | 0.16171 | NA | NA |
| HRAS | alectinib | 0.1622969 | 0.7970975 | 0.16230 | NA | NA |
| BRAF | vismodegib | 0.1624273 | 0.7970975 | 0.16243 | NA | NA |
| IDH2 | afatinib | 0.1625545 | 0.7970975 | 0.16255 | NA | NA |
| TSC2 | temozolomide | 0.1628876 | 0.7970975 | 0.16289 | NA | NA |
| NT5C2 | imatinib | 0.1629599 | 0.7970975 | 0.16296 | NA | NA |
| CDK4 | crizotinib | 0.1634861 | 0.7970975 | 0.16349 | NA | NA |
| MYCN | pazopanib | 0.1635137 | 0.7970975 | 0.16351 | NA | NA |
| GNAS | bosutinib monohydrate | 0.1636359 | 0.7970975 | 0.16364 | NA | NA |
| CD79B | tretinoin | 0.1643471 | 0.7993358 | 0.16435 | NA | NA |
| BCOR | trametinib | 0.1650504 | 0.7996485 | 0.16505 | NA | NA |
| RUNX1 | temozolomide | 0.1651179 | 0.7996485 | 0.16512 | NA | NA |
| EGFR | gefitinib | 0.1651667 | 0.7996485 | 0.16517 | NA | NA |
| GNB1 | cabozantinib | 0.1658940 | 0.8015333 | 0.16589 | NA | NA |
| NRAS | erlotinib | 0.1660607 | 0.8015333 | 0.16606 | NA | NA |
| TET2 | ruxolitinib | 0.1663985 | 0.8019448 | 0.16640 | NA | NA |
| FGFR2 | pazopanib | 0.1667180 | 0.8022670 | 0.16672 | NA | NA |
| TP53 | tretinoin | 0.1673997 | 0.8024203 | 0.16740 | NA | NA |
| GATA1 | crizotinib | 0.1678222 | 0.8024203 | 0.16782 | NA | NA |
| KMT2A | dabrafenib | 0.1680952 | 0.8024203 | 0.16810 | NA | NA |
| PTPN11 | ruxolitinib | 0.1682990 | 0.8024203 | 0.16830 | NA | NA |
| BRCA1 | midostaurin | 0.1683042 | 0.8024203 | 0.16830 | NA | NA |
| FBXW7 | afatinib | 0.1685081 | 0.8024203 | 0.16851 | NA | NA |
| DDIT3 | alectinib | 0.1687949 | 0.8024203 | 0.16879 | NA | NA |
| AKT2 | rucaparib | 0.1688628 | 0.8024203 | 0.16886 | NA | NA |
| NOTCH1 | docetaxel | 0.1690237 | 0.8024203 | 0.16902 | NA | NA |
| MAP2K1 | docetaxel | 0.1700087 | 0.8047151 | 0.17001 | NA | NA |
| ROS1 | docetaxel | 0.1704250 | 0.8047151 | 0.17043 | NA | NA |
| PIK3CA | dabrafenib | 0.1707493 | 0.8047151 | 0.17075 | NA | NA |
| TSC1 | trametinib | 0.1714196 | 0.8047151 | 0.17142 | NA | NA |
| VHL | midostaurin | 0.1715663 | 0.8047151 | 0.17157 | NA | NA |
| AKT3 | temozolomide | 0.1716414 | 0.8047151 | 0.17164 | NA | NA |
| STAG2 | imatinib | 0.1717038 | 0.8047151 | 0.17170 | NA | NA |
| GATA1 | bosutinib monohydrate | 0.1718658 | 0.8047151 | 0.17187 | NA | NA |
| PDGFB | tretinoin | 0.1722109 | 0.8047151 | 0.17221 | NA | NA |
| CDK4 | palbociclib | 0.1723047 | 0.8047151 | 0.17230 | NA | NA |
| EED | ruxolitinib | 0.1723166 | 0.8047151 | 0.17232 | NA | NA |
| EED | dabrafenib | 0.1727152 | 0.8047151 | 0.17272 | NA | NA |
| GATA2 | sunitinib | 0.1728009 | 0.8047151 | 0.17280 | NA | NA |
| AR | rucaparib | 0.1732681 | 0.8049487 | 0.17327 | NA | NA |
| PTCH1 | tretinoin | 0.1733580 | 0.8049487 | 0.17336 | NA | NA |
| PTEN | pazopanib | 0.1738665 | 0.8055178 | 0.17387 | NA | NA |
| VHL | ruxolitinib | 0.1743680 | 0.8055178 | 0.17437 | NA | NA |
| RPL10 | rucaparib | 0.1749059 | 0.8055178 | 0.17491 | NA | NA |
| CBLB | rucaparib | 0.1753511 | 0.8055178 | 0.17535 | NA | NA |
| EML4 | tretinoin | 0.1756579 | 0.8055178 | 0.17566 | NA | NA |
| TSC2 | crizotinib | 0.1757036 | 0.8055178 | 0.17570 | NA | NA |
| MPL | gefitinib | 0.1763514 | 0.8055178 | 0.17635 | NA | NA |
| CD274 | rucaparib | 0.1767650 | 0.8055178 | 0.17677 | NA | NA |
| VHL | crizotinib | 0.1771829 | 0.8055178 | 0.17718 | NA | NA |
| DNAJB1 | dasatinib | 0.1772222 | 0.8055178 | 0.17722 | NA | NA |
| CALR | docetaxel | 0.1774390 | 0.8055178 | 0.17744 | NA | NA |
| ESR1 | nilotinib | 0.1779167 | 0.8055178 | 0.17792 | NA | NA |
| SF1 | imatinib | 0.1779288 | 0.8055178 | 0.17793 | NA | NA |
| NPM1 | cabozantinib | 0.1781069 | 0.8055178 | 0.17811 | NA | NA |
| CTCF | ruxolitinib | 0.1782204 | 0.8055178 | 0.17822 | NA | NA |
| JAK2 | docetaxel | 0.1783666 | 0.8055178 | 0.17837 | NA | NA |
| SMO | lapatinib | 0.1785842 | 0.8055178 | 0.17858 | NA | NA |
| GNAS | nilotinib | 0.1788003 | 0.8055178 | 0.17880 | NA | NA |
| SF1 | cabozantinib | 0.1792187 | 0.8055178 | 0.17922 | NA | NA |
| MDM2 | palbociclib | 0.1794132 | 0.8055178 | 0.17941 | NA | NA |
| PAX5 | erlotinib | 0.1794822 | 0.8055178 | 0.17948 | NA | NA |
| PIGA | erlotinib | 0.1794822 | 0.8055178 | 0.17948 | NA | NA |
| PAX5 | afatinib | 0.1796773 | 0.8055178 | 0.17968 | NA | NA |
| ZRSR2 | afatinib | 0.1797553 | 0.8055178 | 0.17976 | NA | NA |
| FBXW7 | temozolomide | 0.1799955 | 0.8055178 | 0.18000 | NA | NA |
| ERBB2 | belinostat | 0.1805478 | 0.8055178 | 0.18055 | NA | NA |
| FGFR1 | afatinib | 0.1808783 | 0.8055178 | 0.18088 | NA | NA |
| STAT3 | alectinib | 0.1812298 | 0.8055178 | 0.18123 | NA | NA |
| RIT1 | belinostat | 0.1819372 | 0.8055178 | 0.18194 | NA | NA |
| G6PD | docetaxel | 0.1822668 | 0.8055178 | 0.18227 | NA | NA |
| MYD88 | afatinib | 0.1823685 | 0.8055178 | 0.18237 | NA | NA |
| SMC3 | rucaparib | 0.1824393 | 0.8055178 | 0.18244 | NA | NA |
| FGFR3 | belinostat | 0.1830783 | 0.8055178 | 0.18308 | NA | NA |
| WT1 | dasatinib | 0.1833368 | 0.8055178 | 0.18334 | NA | NA |
| SMC1A | gefitinib | 0.1838148 | 0.8055178 | 0.18381 | NA | NA |
| KRAS | afatinib | 0.1838668 | 0.8055178 | 0.18387 | NA | NA |
| CTLA4 | temozolomide | 0.1841506 | 0.8055178 | 0.18415 | NA | NA |
| MET | afatinib | 0.1841947 | 0.8055178 | 0.18419 | NA | NA |
| SF3B1 | lapatinib | 0.1846865 | 0.8055178 | 0.18469 | NA | NA |
| SETBP1 | sunitinib | 0.1847349 | 0.8055178 | 0.18473 | NA | NA |
| ABL1 | belinostat | 0.1850848 | 0.8055178 | 0.18508 | NA | NA |
| GATA1 | palbociclib | 0.1856767 | 0.8055178 | 0.18568 | NA | NA |
| STAG2 | pazopanib | 0.1860023 | 0.8055178 | 0.18600 | NA | NA |
| PAX8 | cabozantinib | 0.1865583 | 0.8055178 | 0.18656 | NA | NA |
| GNA11 | rucaparib | 0.1867700 | 0.8055178 | 0.18677 | NA | NA |
| DNMT3A | nilotinib | 0.1870610 | 0.8055178 | 0.18706 | NA | NA |
| CD274 | ruxolitinib | 0.1870849 | 0.8055178 | 0.18708 | NA | NA |
| SMC3 | midostaurin | 0.1875982 | 0.8055178 | 0.18760 | NA | NA |
| SSX1 | palbociclib | 0.1877964 | 0.8055178 | 0.18780 | NA | NA |
| PTCH1 | bosutinib monohydrate | 0.1879013 | 0.8055178 | 0.18790 | NA | NA |
| BRCA2 | alectinib | 0.1881297 | 0.8055178 | 0.18813 | NA | NA |
| EGF | belinostat | 0.1881458 | 0.8055178 | 0.18815 | NA | NA |
| ALK | sunitinib | 0.1882759 | 0.8055178 | 0.18828 | NA | NA |
| ALK | afatinib | 0.1885392 | 0.8055178 | 0.18854 | NA | NA |
| TSC2 | sunitinib | 0.1886391 | 0.8055178 | 0.18864 | NA | NA |
| PAX5 | temozolomide | 0.1887930 | 0.8055178 | 0.18879 | NA | NA |
| RIT1 | afatinib | 0.1891551 | 0.8055178 | 0.18916 | NA | NA |
| CTNNB1 | alectinib | 0.1894137 | 0.8055178 | 0.18941 | NA | NA |
| TET2 | ponatinib | 0.1895014 | 0.8055178 | 0.18950 | NA | NA |
| PDGFRB | dabrafenib | 0.1895855 | 0.8055178 | 0.18959 | NA | NA |
| MPL | cabozantinib | 0.1896077 | 0.8055178 | 0.18961 | NA | NA |
| RAD21 | crizotinib | 0.1897781 | 0.8055178 | 0.18978 | NA | NA |
| DDIT3 | docetaxel | 0.1899483 | 0.8055178 | 0.18995 | NA | NA |
| DDIT3 | pazopanib | 0.1903063 | 0.8055178 | 0.19031 | NA | NA |
| NCOA2 | erlotinib | 0.1903671 | 0.8055178 | 0.19037 | NA | NA |
| RAD21 | tretinoin | 0.1903979 | 0.8055178 | 0.19040 | NA | NA |
| CRLF2 | palbociclib | 0.1904735 | 0.8055178 | 0.19047 | NA | NA |
| IKZF1 | tretinoin | 0.1918545 | 0.8075109 | 0.19185 | NA | NA |
| CRLF2 | tretinoin | 0.1923461 | 0.8075109 | 0.19235 | NA | NA |
| GNB1 | dabrafenib | 0.1924605 | 0.8075109 | 0.19246 | NA | NA |
| PDCD1 | docetaxel | 0.1924908 | 0.8075109 | 0.19249 | NA | NA |
| TSC1 | midostaurin | 0.1925940 | 0.8075109 | 0.19259 | NA | NA |
| ATM | ponatinib | 0.1926153 | 0.8075109 | 0.19262 | NA | NA |
| NPM1 | imatinib | 0.1935911 | 0.8075109 | 0.19359 | NA | NA |
| GNA11 | vismodegib | 0.1941667 | 0.8075109 | 0.19417 | NA | NA |
| NPM1 | midostaurin | 0.1944832 | 0.8075109 | 0.19448 | NA | NA |
| MGMT | cabozantinib | 0.1946541 | 0.8075109 | 0.19465 | NA | NA |
| CDC73 | rucaparib | 0.1947424 | 0.8075109 | 0.19474 | NA | NA |
| PML | alectinib | 0.1950849 | 0.8075109 | 0.19508 | NA | NA |
| ERBB4 | crizotinib | 0.1962570 | 0.8075109 | 0.19626 | NA | NA |
| PHF6 | docetaxel | 0.1965851 | 0.8075109 | 0.19659 | NA | NA |
| CALR | rucaparib | 0.1970713 | 0.8075109 | 0.19707 | NA | NA |
| FLT3 | rucaparib | 0.1971116 | 0.8075109 | 0.19711 | NA | NA |
| CXCR4 | lapatinib | 0.1971848 | 0.8075109 | 0.19718 | NA | NA |
| CTCF | crizotinib | 0.1973464 | 0.8075109 | 0.19735 | NA | NA |
| EZH2 | erlotinib | 0.1974234 | 0.8075109 | 0.19742 | NA | NA |
| BRAF | ruxolitinib | 0.1976786 | 0.8075109 | 0.19768 | NA | NA |
| FGFR3 | midostaurin | 0.1981794 | 0.8075109 | 0.19818 | NA | NA |
| PDCD1 | nilotinib | 0.1981914 | 0.8075109 | 0.19819 | NA | NA |
| VHL | vismodegib | 0.1982659 | 0.8075109 | 0.19827 | NA | NA |
| PRPF40B | imatinib | 0.1984027 | 0.8075109 | 0.19840 | NA | NA |
| ZRSR2 | imatinib | 0.1984027 | 0.8075109 | 0.19840 | NA | NA |
| SETBP1 | nilotinib | 0.1987831 | 0.8075109 | 0.19878 | NA | NA |
| TSC2 | docetaxel | 0.1988212 | 0.8075109 | 0.19882 | NA | NA |
| SETD2 | cabozantinib | 0.1995660 | 0.8075109 | 0.19957 | NA | NA |
| GNAS | cabozantinib | 0.1996756 | 0.8075109 | 0.19968 | NA | NA |
| CEBPA | midostaurin | 0.1997120 | 0.8075109 | 0.19971 | NA | NA |
| JAK2 | gefitinib | 0.1997501 | 0.8075109 | 0.19975 | NA | NA |
| JAK1 | alectinib | 0.2001873 | 0.8075109 | 0.20019 | NA | NA |
| ESR1 | gefitinib | 0.2002313 | 0.8075109 | 0.20023 | NA | NA |
| GNAQ | belinostat | 0.2006145 | 0.8075109 | 0.20061 | NA | NA |
| UGT1A1 | palbociclib | 0.2007621 | 0.8075109 | 0.20076 | NA | NA |
| GNB1 | nilotinib | 0.2017232 | 0.8075109 | 0.20172 | NA | NA |
| PML | palbociclib | 0.2018104 | 0.8075109 | 0.20181 | NA | NA |
| KIT | dabrafenib | 0.2027554 | 0.8075109 | 0.20276 | NA | NA |
| PDGFRB | erlotinib | 0.2028937 | 0.8075109 | 0.20289 | NA | NA |
| PRPF40B | midostaurin | 0.2032107 | 0.8075109 | 0.20321 | NA | NA |
| U2AF1 | rucaparib | 0.2035438 | 0.8075109 | 0.20354 | NA | NA |
| CD79B | imatinib | 0.2040208 | 0.8075109 | 0.20402 | NA | NA |
| GNAQ | imatinib | 0.2040208 | 0.8075109 | 0.20402 | NA | NA |
| IDH2 | vismodegib | 0.2041835 | 0.8075109 | 0.20418 | NA | NA |
| BCORL1 | dabrafenib | 0.2043963 | 0.8075109 | 0.20440 | NA | NA |
| PHF6 | tretinoin | 0.2045860 | 0.8075109 | 0.20459 | NA | NA |
| PAX5 | crizotinib | 0.2046329 | 0.8075109 | 0.20463 | NA | NA |
| BCORL1 | afatinib | 0.2049112 | 0.8075109 | 0.20491 | NA | NA |
| TSC2 | ponatinib | 0.2051961 | 0.8075109 | 0.20520 | NA | NA |
| CDK6 | dabrafenib | 0.2053813 | 0.8075109 | 0.20538 | NA | NA |
| FLT3 | dasatinib | 0.2059686 | 0.8075109 | 0.20597 | NA | NA |
| MDM2 | tretinoin | 0.2059902 | 0.8075109 | 0.20599 | NA | NA |
| STAG2 | ruxolitinib | 0.2060015 | 0.8075109 | 0.20600 | NA | NA |
| NT5C2 | sunitinib | 0.2060779 | 0.8075109 | 0.20608 | NA | NA |
| CREBBP | temozolomide | 0.2063925 | 0.8075109 | 0.20639 | NA | NA |
| BCORL1 | alectinib | 0.2070853 | 0.8075109 | 0.20709 | NA | NA |
| ERBB4 | palbociclib | 0.2071288 | 0.8075109 | 0.20713 | NA | NA |
| CTNNB1 | imatinib | 0.2072389 | 0.8075109 | 0.20724 | NA | NA |
| EML4 | vismodegib | 0.2074836 | 0.8075109 | 0.20748 | NA | NA |
| GATA3 | temozolomide | 0.2077388 | 0.8075109 | 0.20774 | NA | NA |
| JAK1 | ponatinib | 0.2077854 | 0.8075109 | 0.20779 | NA | NA |
| GATA3 | alectinib | 0.2079277 | 0.8075109 | 0.20793 | NA | NA |
| CDK6 | gefitinib | 0.2081255 | 0.8075109 | 0.20813 | NA | NA |
| CEBPA | tretinoin | 0.2087521 | 0.8075109 | 0.20875 | NA | NA |
| RAD21 | afatinib | 0.2088507 | 0.8075109 | 0.20885 | NA | NA |
| PTEN | alectinib | 0.2092253 | 0.8075109 | 0.20923 | NA | NA |
| PDCD1 | crizotinib | 0.2092666 | 0.8075109 | 0.20927 | NA | NA |
| CALR | cabozantinib | 0.2096259 | 0.8075109 | 0.20963 | NA | NA |
| JAK1 | erlotinib | 0.2097544 | 0.8075109 | 0.20975 | NA | NA |
| MAP2K1 | bosutinib monohydrate | 0.2099067 | 0.8075109 | 0.20991 | NA | NA |
| SRSF2 | vismodegib | 0.2103014 | 0.8075109 | 0.21030 | NA | NA |
| CTNNB1 | afatinib | 0.2104143 | 0.8075109 | 0.21041 | NA | NA |
| JAK2 | temozolomide | 0.2108300 | 0.8075109 | 0.21083 | NA | NA |
| MAP2K2 | midostaurin | 0.2109847 | 0.8075109 | 0.21098 | NA | NA |
| G6PD | afatinib | 0.2109900 | 0.8075109 | 0.21099 | NA | NA |
| EGFR | crizotinib | 0.2113667 | 0.8075109 | 0.21137 | NA | NA |
| GATA1 | dabrafenib | 0.2115052 | 0.8075109 | 0.21151 | NA | NA |
| ABL1 | palbociclib | 0.2122468 | 0.8075109 | 0.21225 | NA | NA |
| PTPN11 | bosutinib monohydrate | 0.2124694 | 0.8075109 | 0.21247 | NA | NA |
| STAG2 | nilotinib | 0.2125771 | 0.8075109 | 0.21258 | NA | NA |
| SF1 | bosutinib monohydrate | 0.2126871 | 0.8075109 | 0.21269 | NA | NA |
| IKZF1 | nilotinib | 0.2133452 | 0.8075109 | 0.21335 | NA | NA |
| U2AF1 | cabozantinib | 0.2134027 | 0.8075109 | 0.21340 | NA | NA |
| AR | lapatinib | 0.2135960 | 0.8075109 | 0.21360 | NA | NA |
| PDCD1 | palbociclib | 0.2138133 | 0.8075109 | 0.21381 | NA | NA |
| FGFR1 | docetaxel | 0.2138153 | 0.8075109 | 0.21382 | NA | NA |
| CDKN2A | pazopanib | 0.2139961 | 0.8075109 | 0.21400 | NA | NA |
| SF3B1 | docetaxel | 0.2143435 | 0.8075109 | 0.21434 | NA | NA |
| STAG2 | alectinib | 0.2144126 | 0.8075109 | 0.21441 | NA | NA |
| SMO | dasatinib | 0.2145199 | 0.8075109 | 0.21452 | NA | NA |
| EGF | dabrafenib | 0.2146958 | 0.8075109 | 0.21470 | NA | NA |
| ESR1 | palbociclib | 0.2146985 | 0.8075109 | 0.21470 | NA | NA |
| MAP2K1 | trametinib | 0.2151783 | 0.8075109 | 0.21518 | NA | NA |
| JAK3 | dasatinib | 0.2151836 | 0.8075109 | 0.21518 | NA | NA |
| MPL | midostaurin | 0.2151839 | 0.8075109 | 0.21518 | NA | NA |
| RAD21 | temozolomide | 0.2154867 | 0.8075109 | 0.21549 | NA | NA |
| AKT2 | gefitinib | 0.2158478 | 0.8075109 | 0.21585 | NA | NA |
| NPM1 | erlotinib | 0.2158617 | 0.8075109 | 0.21586 | NA | NA |
| BCORL1 | bosutinib monohydrate | 0.2167334 | 0.8081277 | 0.21673 | NA | NA |
| PTCH1 | temozolomide | 0.2167760 | 0.8081277 | 0.21678 | NA | NA |
| MAP2K1 | crizotinib | 0.2167899 | 0.8081277 | 0.21679 | NA | NA |
| DNAJB1 | lapatinib | 0.2180070 | 0.8105176 | 0.21801 | NA | NA |
| ESR1 | belinostat | 0.2186179 | 0.8105176 | 0.21862 | NA | NA |
| IL7R | erlotinib | 0.2186340 | 0.8105176 | 0.21863 | NA | NA |
| CTCF | imatinib | 0.2188316 | 0.8105176 | 0.21883 | NA | NA |
| SF1 | pazopanib | 0.2189633 | 0.8105176 | 0.21896 | NA | NA |
| MYCN | ruxolitinib | 0.2191911 | 0.8105176 | 0.21919 | NA | NA |
| MYD88 | belinostat | 0.2195610 | 0.8105176 | 0.21956 | NA | NA |
| IKZF1 | midostaurin | 0.2196854 | 0.8105176 | 0.21969 | NA | NA |
| GATA2 | erlotinib | 0.2198677 | 0.8105176 | 0.21987 | NA | NA |
| BRCA1 | vismodegib | 0.2203270 | 0.8105176 | 0.22033 | NA | NA |
| CBLB | trametinib | 0.2206325 | 0.8105176 | 0.22063 | NA | NA |
| NOTCH2 | dasatinib | 0.2206354 | 0.8105176 | 0.22064 | NA | NA |
| SMC1A | lapatinib | 0.2210226 | 0.8105176 | 0.22102 | NA | NA |
| PML | temozolomide | 0.2217712 | 0.8105176 | 0.22177 | NA | NA |
| CEBPA | palbociclib | 0.2217988 | 0.8105176 | 0.22180 | NA | NA |
| PTPN11 | midostaurin | 0.2220450 | 0.8105176 | 0.22204 | NA | NA |
| NT5C2 | nilotinib | 0.2223316 | 0.8105176 | 0.22233 | NA | NA |
| PAX5 | imatinib | 0.2228977 | 0.8105176 | 0.22290 | NA | NA |
| CEBPA | alectinib | 0.2230121 | 0.8105176 | 0.22301 | NA | NA |
| PDGFB | vismodegib | 0.2233811 | 0.8105176 | 0.22338 | NA | NA |
| ROS1 | belinostat | 0.2235080 | 0.8105176 | 0.22351 | NA | NA |
| MDM2 | midostaurin | 0.2236312 | 0.8105176 | 0.22363 | NA | NA |
| KRAS | tretinoin | 0.2237016 | 0.8105176 | 0.22370 | NA | NA |
| CDK4 | lapatinib | 0.2244316 | 0.8105176 | 0.22443 | NA | NA |
| NPM1 | alectinib | 0.2246258 | 0.8105176 | 0.22463 | NA | NA |
| U2AF1 | trametinib | 0.2247977 | 0.8105176 | 0.22480 | NA | NA |
| NT5C2 | cabozantinib | 0.2249494 | 0.8105176 | 0.22495 | NA | NA |
| HRAS | cabozantinib | 0.2251053 | 0.8105176 | 0.22511 | NA | NA |
| TET2 | lapatinib | 0.2251236 | 0.8105176 | 0.22512 | NA | NA |
| RIT1 | erlotinib | 0.2253417 | 0.8105176 | 0.22534 | NA | NA |
| RIT1 | lapatinib | 0.2253423 | 0.8105176 | 0.22534 | NA | NA |
| DNMT3A | dasatinib | 0.2260896 | 0.8116726 | 0.22609 | NA | NA |
| SMC1A | erlotinib | 0.2261745 | 0.8116726 | 0.22617 | NA | NA |
| TET2 | tretinoin | 0.2269477 | 0.8135281 | 0.22695 | NA | NA |
| NOTCH1 | vismodegib | 0.2273665 | 0.8141105 | 0.22737 | NA | NA |
| DDIT3 | palbociclib | 0.2290040 | 0.8157603 | 0.22900 | NA | NA |
| RIT1 | alectinib | 0.2291396 | 0.8157603 | 0.22914 | NA | NA |
| TP53 | ruxolitinib | 0.2293455 | 0.8157603 | 0.22935 | NA | NA |
| ALK | ruxolitinib | 0.2294413 | 0.8157603 | 0.22944 | NA | NA |
| FGFR3 | trametinib | 0.2295042 | 0.8157603 | 0.22950 | NA | NA |
| PDGFB | afatinib | 0.2297013 | 0.8157603 | 0.22970 | NA | NA |
| PAX5 | bosutinib monohydrate | 0.2299628 | 0.8157603 | 0.22996 | NA | NA |
| PTEN | sunitinib | 0.2301212 | 0.8157603 | 0.23012 | NA | NA |
| MPL | temozolomide | 0.2305412 | 0.8157603 | 0.23054 | NA | NA |
| NRAS | ruxolitinib | 0.2306461 | 0.8157603 | 0.23065 | NA | NA |
| FANCL | erlotinib | 0.2309123 | 0.8157603 | 0.23091 | NA | NA |
| GNAQ | dabrafenib | 0.2310189 | 0.8157603 | 0.23102 | NA | NA |
| DPYD | ponatinib | 0.2315390 | 0.8157603 | 0.23154 | NA | NA |
| GATA1 | midostaurin | 0.2317022 | 0.8157603 | 0.23170 | NA | NA |
| CEBPA | ruxolitinib | 0.2318168 | 0.8157603 | 0.23182 | NA | NA |
| FANCL | nilotinib | 0.2322908 | 0.8157603 | 0.23229 | NA | NA |
| G6PD | ruxolitinib | 0.2325984 | 0.8157603 | 0.23260 | NA | NA |
| KIT | vismodegib | 0.2326739 | 0.8157603 | 0.23267 | NA | NA |
| BCORL1 | ponatinib | 0.2327074 | 0.8157603 | 0.23271 | NA | NA |
| PDCD1 | bosutinib monohydrate | 0.2330839 | 0.8161792 | 0.23308 | NA | NA |
| ROS1 | alectinib | 0.2335276 | 0.8162872 | 0.23353 | NA | NA |
| ATM | sunitinib | 0.2338151 | 0.8162872 | 0.23382 | NA | NA |
| PDCD1 | alectinib | 0.2338858 | 0.8162872 | 0.23389 | NA | NA |
| ABL1 | lapatinib | 0.2342922 | 0.8168079 | 0.23429 | NA | NA |
| SF3B1 | vismodegib | 0.2348374 | 0.8170790 | 0.23484 | NA | NA |
| GATA3 | sunitinib | 0.2349335 | 0.8170790 | 0.23493 | NA | NA |
| CTCF | rucaparib | 0.2351418 | 0.8170790 | 0.23514 | NA | NA |
| NT5C2 | tretinoin | 0.2358069 | 0.8184948 | 0.23581 | NA | NA |
| FBXW7 | dasatinib | 0.2361556 | 0.8186906 | 0.23616 | NA | NA |
| WT1 | gefitinib | 0.2363973 | 0.8186906 | 0.23640 | NA | NA |
| IL7R | midostaurin | 0.2368814 | 0.8186906 | 0.23688 | NA | NA |
| SSX1 | pazopanib | 0.2368944 | 0.8186906 | 0.23689 | NA | NA |
| PTCH1 | belinostat | 0.2376997 | 0.8205806 | 0.23770 | NA | NA |
| GNAS | sunitinib | 0.2380488 | 0.8208594 | 0.23805 | NA | NA |
| JAK2 | alectinib | 0.2385373 | 0.8208594 | 0.23854 | NA | NA |
| FANCL | crizotinib | 0.2386699 | 0.8208594 | 0.23867 | NA | NA |
| MGMT | palbociclib | 0.2389195 | 0.8208594 | 0.23892 | NA | NA |
| TSC2 | alectinib | 0.2393143 | 0.8208594 | 0.23931 | NA | NA |
| BCORL1 | pazopanib | 0.2394178 | 0.8208594 | 0.23942 | NA | NA |
| GATA1 | imatinib | 0.2395896 | 0.8208594 | 0.23959 | NA | NA |
| HRAS | nilotinib | 0.2403406 | 0.8225451 | 0.24034 | NA | NA |
| RIT1 | palbociclib | 0.2411715 | 0.8232292 | 0.24117 | NA | NA |
| NT5C2 | dasatinib | 0.2417207 | 0.8232292 | 0.24172 | NA | NA |
| CREBBP | trametinib | 0.2417435 | 0.8232292 | 0.24174 | NA | NA |
| CXCR4 | dabrafenib | 0.2424069 | 0.8232292 | 0.24241 | NA | NA |
| CYP19A1 | trametinib | 0.2426959 | 0.8232292 | 0.24270 | NA | NA |
| MDM2 | afatinib | 0.2429813 | 0.8232292 | 0.24298 | NA | NA |
| VHL | alectinib | 0.2439120 | 0.8232292 | 0.24391 | NA | NA |
| CTCF | cabozantinib | 0.2443216 | 0.8232292 | 0.24432 | NA | NA |
| G6PD | dabrafenib | 0.2443393 | 0.8232292 | 0.24434 | NA | NA |
| AKT2 | tretinoin | 0.2446468 | 0.8232292 | 0.24465 | NA | NA |
| CBLB | ruxolitinib | 0.2446656 | 0.8232292 | 0.24467 | NA | NA |
| SMC3 | vismodegib | 0.2452829 | 0.8232292 | 0.24528 | NA | NA |
| SH2B3 | dabrafenib | 0.2453136 | 0.8232292 | 0.24531 | NA | NA |
| EGF | bosutinib monohydrate | 0.2453569 | 0.8232292 | 0.24536 | NA | NA |
| FGFR2 | temozolomide | 0.2455699 | 0.8232292 | 0.24557 | NA | NA |
| DPYD | trametinib | 0.2458254 | 0.8232292 | 0.24583 | NA | NA |
| G6PD | vismodegib | 0.2460143 | 0.8232292 | 0.24601 | NA | NA |
| EGF | docetaxel | 0.2461603 | 0.8232292 | 0.24616 | NA | NA |
| CBLB | bosutinib monohydrate | 0.2461824 | 0.8232292 | 0.24618 | NA | NA |
| PDCD1 | cabozantinib | 0.2464043 | 0.8232292 | 0.24640 | NA | NA |
| ABL1 | alectinib | 0.2470177 | 0.8232292 | 0.24702 | NA | NA |
| GATA3 | imatinib | 0.2473162 | 0.8232292 | 0.24732 | NA | NA |
| TSC1 | vismodegib | 0.2476631 | 0.8232292 | 0.24766 | NA | NA |
| IDH2 | bosutinib monohydrate | 0.2477175 | 0.8232292 | 0.24772 | NA | NA |
| CTNNB1 | bosutinib monohydrate | 0.2477885 | 0.8232292 | 0.24779 | NA | NA |
| GNA11 | docetaxel | 0.2485190 | 0.8232292 | 0.24852 | NA | NA |
| ERBB3 | tretinoin | 0.2487626 | 0.8232292 | 0.24876 | NA | NA |
| NPM1 | docetaxel | 0.2488101 | 0.8232292 | 0.24881 | NA | NA |
| RAD21 | rucaparib | 0.2491994 | 0.8232292 | 0.24920 | NA | NA |
| RET | trametinib | 0.2493948 | 0.8232292 | 0.24939 | NA | NA |
| RAD21 | palbociclib | 0.2494293 | 0.8232292 | 0.24943 | NA | NA |
| KRAS | ponatinib | 0.2496849 | 0.8232292 | 0.24968 | NA | NA |
| BTK | afatinib | 0.2500025 | 0.8232292 | 0.25000 | NA | NA |
| NRAS | palbociclib | 0.2500055 | 0.8232292 | 0.25001 | NA | NA |
| ASXL1 | dasatinib | 0.2501299 | 0.8232292 | 0.25013 | NA | NA |
| PDGFB | imatinib | 0.2502352 | 0.8232292 | 0.25024 | NA | NA |
| XPO1 | belinostat | 0.2503343 | 0.8232292 | 0.25033 | NA | NA |
| CRLF2 | pazopanib | 0.2509570 | 0.8232292 | 0.25096 | NA | NA |
| AKT2 | ponatinib | 0.2512025 | 0.8232292 | 0.25120 | NA | NA |
| JAK1 | vismodegib | 0.2513278 | 0.8232292 | 0.25133 | NA | NA |
| CALR | lapatinib | 0.2514271 | 0.8232292 | 0.25143 | NA | NA |
| MGMT | lapatinib | 0.2514271 | 0.8232292 | 0.25143 | NA | NA |
| MPL | crizotinib | 0.2519796 | 0.8239178 | 0.25198 | NA | NA |
| ERBB2 | dabrafenib | 0.2521562 | 0.8239178 | 0.25216 | NA | NA |
| PML | dabrafenib | 0.2532744 | 0.8255685 | 0.25327 | NA | NA |
| HRAS | tretinoin | 0.2537166 | 0.8255685 | 0.25372 | NA | NA |
| EGFR | dasatinib | 0.2539632 | 0.8255685 | 0.25396 | NA | NA |
| CALR | imatinib | 0.2539993 | 0.8255685 | 0.25400 | NA | NA |
| AKT2 | erlotinib | 0.2541238 | 0.8255685 | 0.25412 | NA | NA |
| BRCA1 | bosutinib monohydrate | 0.2550079 | 0.8255685 | 0.25501 | NA | NA |
| BRCA2 | afatinib | 0.2553180 | 0.8255685 | 0.25532 | NA | NA |
| DNAJB1 | midostaurin | 0.2553242 | 0.8255685 | 0.25532 | NA | NA |
| EML4 | rucaparib | 0.2555029 | 0.8255685 | 0.25550 | NA | NA |
| EGF | cabozantinib | 0.2557242 | 0.8255685 | 0.25572 | NA | NA |
| CTLA4 | afatinib | 0.2557520 | 0.8255685 | 0.25575 | NA | NA |
| IDH1 | docetaxel | 0.2558126 | 0.8255685 | 0.25581 | NA | NA |
| PML | sunitinib | 0.2560406 | 0.8255685 | 0.25604 | NA | NA |
| MAP2K2 | vismodegib | 0.2563401 | 0.8256959 | 0.25634 | NA | NA |
| TP53 | temozolomide | 0.2572528 | 0.8275374 | 0.25725 | NA | NA |
| PHF6 | gefitinib | 0.2574329 | 0.8275374 | 0.25743 | NA | NA |
| HRAS | belinostat | 0.2579401 | 0.8276485 | 0.25794 | NA | NA |
| CD274 | midostaurin | 0.2584055 | 0.8276485 | 0.25841 | NA | NA |
| TSC2 | palbociclib | 0.2593090 | 0.8276485 | 0.25931 | NA | NA |
| RUNX1 | rucaparib | 0.2593719 | 0.8276485 | 0.25937 | NA | NA |
| SH2B3 | afatinib | 0.2597980 | 0.8276485 | 0.25980 | NA | NA |
| CALR | tretinoin | 0.2599107 | 0.8276485 | 0.25991 | NA | NA |
| ERBB4 | afatinib | 0.2599147 | 0.8276485 | 0.25991 | NA | NA |
| CDKN2A | alectinib | 0.2605683 | 0.8276485 | 0.26057 | NA | NA |
| SF3B1 | afatinib | 0.2607779 | 0.8276485 | 0.26078 | NA | NA |
| IDH2 | ponatinib | 0.2610616 | 0.8276485 | 0.26106 | NA | NA |
| ERBB4 | imatinib | 0.2611044 | 0.8276485 | 0.26110 | NA | NA |
| STAT3 | dasatinib | 0.2617061 | 0.8276485 | 0.26171 | NA | NA |
| CSF3R | midostaurin | 0.2617885 | 0.8276485 | 0.26179 | NA | NA |
| PTCH1 | ponatinib | 0.2619913 | 0.8276485 | 0.26199 | NA | NA |
| GATA2 | dasatinib | 0.2620633 | 0.8276485 | 0.26206 | NA | NA |
| UGT1A1 | crizotinib | 0.2625570 | 0.8276485 | 0.26256 | NA | NA |
| NOTCH1 | dasatinib | 0.2625738 | 0.8276485 | 0.26257 | NA | NA |
| TPMT | docetaxel | 0.2626723 | 0.8276485 | 0.26267 | NA | NA |
| BCOR | rucaparib | 0.2627595 | 0.8276485 | 0.26276 | NA | NA |
| PTCH1 | afatinib | 0.2628105 | 0.8276485 | 0.26281 | NA | NA |
| PDGFB | lapatinib | 0.2633229 | 0.8276485 | 0.26332 | NA | NA |
| CDKN2A | gefitinib | 0.2634206 | 0.8276485 | 0.26342 | NA | NA |
| PDCD1 | ruxolitinib | 0.2638283 | 0.8276485 | 0.26383 | NA | NA |
| CEBPA | vismodegib | 0.2638745 | 0.8276485 | 0.26387 | NA | NA |
| DNMT3A | afatinib | 0.2639824 | 0.8276485 | 0.26398 | NA | NA |
| U2AF1 | nilotinib | 0.2644922 | 0.8284294 | 0.26449 | NA | NA |
| TPMT | vismodegib | 0.2650075 | 0.8286589 | 0.26501 | NA | NA |
| SETD2 | vismodegib | 0.2650874 | 0.8286589 | 0.26509 | NA | NA |
| U2AF1 | ponatinib | 0.2666179 | 0.8315214 | 0.26662 | NA | NA |
| BRAF | docetaxel | 0.2666895 | 0.8315214 | 0.26669 | NA | NA |
| NRAS | dabrafenib | 0.2669909 | 0.8315214 | 0.26699 | NA | NA |
| MGMT | midostaurin | 0.2670503 | 0.8315214 | 0.26705 | NA | NA |
| ZRSR2 | docetaxel | 0.2674973 | 0.8317549 | 0.26750 | NA | NA |
| DNAJB1 | crizotinib | 0.2676694 | 0.8317549 | 0.26767 | NA | NA |
| PIGA | pazopanib | 0.2681396 | 0.8317549 | 0.26814 | NA | NA |
| PIGA | rucaparib | 0.2683194 | 0.8317549 | 0.26832 | NA | NA |
| DNMT3A | cabozantinib | 0.2687536 | 0.8317549 | 0.26875 | NA | NA |
| TP53 | pazopanib | 0.2688657 | 0.8317549 | 0.26887 | NA | NA |
| DPYD | dabrafenib | 0.2691497 | 0.8317549 | 0.26915 | NA | NA |
| SETD2 | imatinib | 0.2695411 | 0.8317549 | 0.26954 | NA | NA |
| JAK3 | belinostat | 0.2699558 | 0.8317549 | 0.26996 | NA | NA |
| JAK2 | tretinoin | 0.2702044 | 0.8317549 | 0.27020 | NA | NA |
| FANCL | palbociclib | 0.2705871 | 0.8317549 | 0.27059 | NA | NA |
| EGFR | alectinib | 0.2707820 | 0.8317549 | 0.27078 | NA | NA |
| AR | ruxolitinib | 0.2707866 | 0.8317549 | 0.27079 | NA | NA |
| STAT3 | sunitinib | 0.2711355 | 0.8317549 | 0.27114 | NA | NA |
| ALK | belinostat | 0.2712457 | 0.8317549 | 0.27125 | NA | NA |
| TP53 | ponatinib | 0.2715421 | 0.8317549 | 0.27154 | NA | NA |
| GATA1 | cabozantinib | 0.2722065 | 0.8317549 | 0.27221 | NA | NA |
| AKT1 | vismodegib | 0.2724738 | 0.8317549 | 0.27247 | NA | NA |
| KRAS | docetaxel | 0.2725554 | 0.8317549 | 0.27256 | NA | NA |
| RAD21 | trametinib | 0.2729462 | 0.8317549 | 0.27295 | NA | NA |
| NPM1 | lapatinib | 0.2737483 | 0.8317549 | 0.27375 | NA | NA |
| TPMT | nilotinib | 0.2737875 | 0.8317549 | 0.27379 | NA | NA |
| PDGFRB | nilotinib | 0.2738696 | 0.8317549 | 0.27387 | NA | NA |
| ERBB2 | trametinib | 0.2740267 | 0.8317549 | 0.27403 | NA | NA |
| CDC73 | afatinib | 0.2743006 | 0.8317549 | 0.27430 | NA | NA |
| SMC1A | bosutinib monohydrate | 0.2743651 | 0.8317549 | 0.27437 | NA | NA |
| NCOA2 | rucaparib | 0.2744830 | 0.8317549 | 0.27448 | NA | NA |
| MAP2K2 | gefitinib | 0.2745244 | 0.8317549 | 0.27452 | NA | NA |
| NPM1 | temozolomide | 0.2747200 | 0.8317549 | 0.27472 | NA | NA |
| PDGFB | nilotinib | 0.2752114 | 0.8320379 | 0.27521 | NA | NA |
| RIT1 | bosutinib monohydrate | 0.2754670 | 0.8320379 | 0.27547 | NA | NA |
| EML4 | bosutinib monohydrate | 0.2755994 | 0.8320379 | 0.27560 | NA | NA |
| RUNX1 | cabozantinib | 0.2760789 | 0.8326939 | 0.27608 | NA | NA |
| DNAJB1 | bosutinib monohydrate | 0.2768690 | 0.8342846 | 0.27687 | NA | NA |
| TET2 | midostaurin | 0.2773549 | 0.8343796 | 0.27735 | NA | NA |
| EZH2 | docetaxel | 0.2774451 | 0.8343796 | 0.27745 | NA | NA |
| SRSF2 | afatinib | 0.2781061 | 0.8343796 | 0.27811 | NA | NA |
| PTEN | ponatinib | 0.2782635 | 0.8343796 | 0.27826 | NA | NA |
| CBL | gefitinib | 0.2788384 | 0.8343796 | 0.27884 | NA | NA |
| CTLA4 | docetaxel | 0.2788643 | 0.8343796 | 0.27886 | NA | NA |
| AR | crizotinib | 0.2791398 | 0.8343796 | 0.27914 | NA | NA |
| PIGA | afatinib | 0.2792417 | 0.8343796 | 0.27924 | NA | NA |
| GNA11 | midostaurin | 0.2792650 | 0.8343796 | 0.27926 | NA | NA |
| JAK2 | rucaparib | 0.2799799 | 0.8351327 | 0.27998 | NA | NA |
| CD274 | docetaxel | 0.2805815 | 0.8351327 | 0.28058 | NA | NA |
| MDM2 | alectinib | 0.2810211 | 0.8351327 | 0.28102 | NA | NA |
| SRSF2 | tretinoin | 0.2812022 | 0.8351327 | 0.28120 | NA | NA |
| SRSF2 | nilotinib | 0.2812050 | 0.8351327 | 0.28120 | NA | NA |
| KIT | ruxolitinib | 0.2812051 | 0.8351327 | 0.28121 | NA | NA |
| JAK1 | midostaurin | 0.2818427 | 0.8351327 | 0.28184 | NA | NA |
| PDGFRB | docetaxel | 0.2818564 | 0.8351327 | 0.28186 | NA | NA |
| ERBB4 | lapatinib | 0.2819297 | 0.8351327 | 0.28193 | NA | NA |
| CSF3R | dabrafenib | 0.2822100 | 0.8351327 | 0.28221 | NA | NA |
| SF3B1 | erlotinib | 0.2824110 | 0.8351327 | 0.28241 | NA | NA |
| BCORL1 | lapatinib | 0.2829109 | 0.8351327 | 0.28291 | NA | NA |
| MPL | docetaxel | 0.2836659 | 0.8351327 | 0.28367 | NA | NA |
| RIT1 | ponatinib | 0.2845500 | 0.8351327 | 0.28455 | NA | NA |
| PHF6 | dasatinib | 0.2853231 | 0.8351327 | 0.28532 | NA | NA |
| PTEN | palbociclib | 0.2856346 | 0.8351327 | 0.28563 | NA | NA |
| CDK6 | ruxolitinib | 0.2857749 | 0.8351327 | 0.28577 | NA | NA |
| NCOA2 | palbociclib | 0.2859635 | 0.8351327 | 0.28596 | NA | NA |
| CD79B | lapatinib | 0.2864755 | 0.8351327 | 0.28648 | NA | NA |
| GNAQ | lapatinib | 0.2864755 | 0.8351327 | 0.28648 | NA | NA |
| JAK3 | docetaxel | 0.2865263 | 0.8351327 | 0.28653 | NA | NA |
| CXCR4 | docetaxel | 0.2866824 | 0.8351327 | 0.28668 | NA | NA |
| RIT1 | nilotinib | 0.2868250 | 0.8351327 | 0.28682 | NA | NA |
| PAX5 | pazopanib | 0.2868988 | 0.8351327 | 0.28690 | NA | NA |
| CXCR4 | sunitinib | 0.2869137 | 0.8351327 | 0.28691 | NA | NA |
| FGFR1 | gefitinib | 0.2872103 | 0.8351327 | 0.28721 | NA | NA |
| PDGFRA | midostaurin | 0.2883532 | 0.8351327 | 0.28835 | NA | NA |
| GNB1 | bosutinib monohydrate | 0.2886360 | 0.8351327 | 0.28864 | NA | NA |
| ERBB3 | cabozantinib | 0.2887403 | 0.8351327 | 0.28874 | NA | NA |
| CTNNB1 | dabrafenib | 0.2892579 | 0.8351327 | 0.28926 | NA | NA |
| ZRSR2 | sunitinib | 0.2895406 | 0.8351327 | 0.28954 | NA | NA |
| CDK6 | midostaurin | 0.2899976 | 0.8351327 | 0.29000 | NA | NA |
| MET | palbociclib | 0.2900431 | 0.8351327 | 0.29004 | NA | NA |
| MET | vismodegib | 0.2900560 | 0.8351327 | 0.29006 | NA | NA |
| FGFR3 | dasatinib | 0.2900699 | 0.8351327 | 0.29007 | NA | NA |
| GNB1 | sunitinib | 0.2903826 | 0.8351327 | 0.29038 | NA | NA |
| RAD21 | erlotinib | 0.2906403 | 0.8351327 | 0.29064 | NA | NA |
| CDK6 | rucaparib | 0.2907652 | 0.8351327 | 0.29077 | NA | NA |
| BRCA2 | bosutinib monohydrate | 0.2907814 | 0.8351327 | 0.29078 | NA | NA |
| CD79B | alectinib | 0.2908767 | 0.8351327 | 0.29088 | NA | NA |
| EML4 | sunitinib | 0.2909234 | 0.8351327 | 0.29092 | NA | NA |
| PIGA | midostaurin | 0.2909512 | 0.8351327 | 0.29095 | NA | NA |
| AKT3 | tretinoin | 0.2910595 | 0.8351327 | 0.29106 | NA | NA |
| CBL | temozolomide | 0.2912507 | 0.8351327 | 0.29125 | NA | NA |
| FANCL | dasatinib | 0.2913498 | 0.8351327 | 0.29135 | NA | NA |
| CDKN2A | erlotinib | 0.2916190 | 0.8351504 | 0.29162 | NA | NA |
| EGF | ponatinib | 0.2924029 | 0.8364196 | 0.29240 | NA | NA |
| KRAS | midostaurin | 0.2927354 | 0.8364196 | 0.29274 | NA | NA |
| SETBP1 | pazopanib | 0.2928522 | 0.8364196 | 0.29285 | NA | NA |
| CD274 | dabrafenib | 0.2936109 | 0.8370865 | 0.29361 | NA | NA |
| U2AF1 | imatinib | 0.2938112 | 0.8370865 | 0.29381 | NA | NA |
| CSF3R | trametinib | 0.2947229 | 0.8370865 | 0.29472 | NA | NA |
| CD79B | sunitinib | 0.2950346 | 0.8370865 | 0.29503 | NA | NA |
| GNAQ | sunitinib | 0.2950346 | 0.8370865 | 0.29503 | NA | NA |
| PTCH1 | pazopanib | 0.2950783 | 0.8370865 | 0.29508 | NA | NA |
| FANCL | pazopanib | 0.2951768 | 0.8370865 | 0.29518 | NA | NA |
| SETBP1 | dabrafenib | 0.2954170 | 0.8370865 | 0.29542 | NA | NA |
| AKT1 | alectinib | 0.2956410 | 0.8370865 | 0.29564 | NA | NA |
| UGT1A1 | imatinib | 0.2957214 | 0.8370865 | 0.29572 | NA | NA |
| ROS1 | bosutinib monohydrate | 0.2963370 | 0.8380823 | 0.29634 | NA | NA |
| CBL | rucaparib | 0.2974374 | 0.8390803 | 0.29744 | NA | NA |
| SMC1A | temozolomide | 0.2977471 | 0.8390803 | 0.29775 | NA | NA |
| FLT3 | trametinib | 0.2977892 | 0.8390803 | 0.29779 | NA | NA |
| XPO1 | imatinib | 0.2979122 | 0.8390803 | 0.29791 | NA | NA |
| BTK | imatinib | 0.2980109 | 0.8390803 | 0.29801 | NA | NA |
| FGFR1 | alectinib | 0.3000040 | 0.8431304 | 0.30000 | NA | NA |
| RIT1 | gefitinib | 0.3002316 | 0.8431304 | 0.30023 | NA | NA |
| MYCN | docetaxel | 0.3007324 | 0.8431304 | 0.30073 | NA | NA |
| JAK3 | alectinib | 0.3008462 | 0.8431304 | 0.30085 | NA | NA |
| ERBB4 | dasatinib | 0.3011735 | 0.8431304 | 0.30117 | NA | NA |
| ERBB2 | tretinoin | 0.3012993 | 0.8431304 | 0.30130 | NA | NA |
| PIGA | temozolomide | 0.3013076 | 0.8431304 | 0.30131 | NA | NA |
| XPO1 | ruxolitinib | 0.3027717 | 0.8464813 | 0.30277 | NA | NA |
| DNAJB1 | temozolomide | 0.3033881 | 0.8469194 | 0.30339 | NA | NA |
| SF3B1 | rucaparib | 0.3037310 | 0.8469194 | 0.30373 | NA | NA |
| GNAS | vismodegib | 0.3041539 | 0.8469194 | 0.30415 | NA | NA |
| AKT1 | ruxolitinib | 0.3044779 | 0.8469194 | 0.30448 | NA | NA |
| TSC1 | ruxolitinib | 0.3045736 | 0.8469194 | 0.30457 | NA | NA |
| DPYD | cabozantinib | 0.3047799 | 0.8469194 | 0.30478 | NA | NA |
| IDH2 | pazopanib | 0.3050404 | 0.8469194 | 0.30504 | NA | NA |
| ASXL1 | trametinib | 0.3050617 | 0.8469194 | 0.30506 | NA | NA |
| PRPF40B | nilotinib | 0.3059911 | 0.8479355 | 0.30599 | NA | NA |
| MDM2 | dabrafenib | 0.3064629 | 0.8479355 | 0.30646 | NA | NA |
| BTK | trametinib | 0.3064806 | 0.8479355 | 0.30648 | NA | NA |
| SF3B1 | midostaurin | 0.3064956 | 0.8479355 | 0.30650 | NA | NA |
| PAX8 | bosutinib monohydrate | 0.3070631 | 0.8487663 | 0.30706 | NA | NA |
| NOTCH1 | bosutinib monohydrate | 0.3085065 | 0.8511104 | 0.30851 | NA | NA |
| FBXW7 | midostaurin | 0.3089074 | 0.8511104 | 0.30891 | NA | NA |
| PTCH1 | nilotinib | 0.3093982 | 0.8511104 | 0.30940 | NA | NA |
| BCORL1 | tretinoin | 0.3097124 | 0.8511104 | 0.30971 | NA | NA |
| GNAS | alectinib | 0.3097168 | 0.8511104 | 0.30972 | NA | NA |
| BRAF | tretinoin | 0.3097622 | 0.8511104 | 0.30976 | NA | NA |
| XPO1 | docetaxel | 0.3105293 | 0.8511104 | 0.31053 | NA | NA |
| DPYD | afatinib | 0.3107947 | 0.8511104 | 0.31079 | NA | NA |
| TSC1 | imatinib | 0.3108496 | 0.8511104 | 0.31085 | NA | NA |
| MGMT | rucaparib | 0.3112521 | 0.8511104 | 0.31125 | NA | NA |
| BTK | sunitinib | 0.3113123 | 0.8511104 | 0.31131 | NA | NA |
| ERBB4 | temozolomide | 0.3115486 | 0.8511104 | 0.31155 | NA | NA |
| WHSC1 | tretinoin | 0.3115987 | 0.8511104 | 0.31160 | NA | NA |
| TPMT | gefitinib | 0.3116629 | 0.8511104 | 0.31166 | NA | NA |
| ERBB2 | dasatinib | 0.3121664 | 0.8514890 | 0.31217 | NA | NA |
| NT5C2 | belinostat | 0.3123377 | 0.8514890 | 0.31234 | NA | NA |
| VHL | dasatinib | 0.3136021 | 0.8530655 | 0.31360 | NA | NA |
| MET | tretinoin | 0.3136957 | 0.8530655 | 0.31370 | NA | NA |
| BRCA2 | rucaparib | 0.3140675 | 0.8530655 | 0.31407 | NA | NA |
| NRAS | tretinoin | 0.3141618 | 0.8530655 | 0.31416 | NA | NA |
| PDGFRA | imatinib | 0.3143676 | 0.8530655 | 0.31437 | NA | NA |
| CDK6 | cabozantinib | 0.3152330 | 0.8530655 | 0.31523 | NA | NA |
| GATA1 | sunitinib | 0.3154704 | 0.8530655 | 0.31547 | NA | NA |
| ESR1 | rucaparib | 0.3155348 | 0.8530655 | 0.31553 | NA | NA |
| KRAS | belinostat | 0.3158051 | 0.8530655 | 0.31581 | NA | NA |
| ERBB2 | imatinib | 0.3160344 | 0.8530655 | 0.31603 | NA | NA |
| CYP19A1 | belinostat | 0.3161498 | 0.8530655 | 0.31615 | NA | NA |
| SF1 | docetaxel | 0.3162400 | 0.8530655 | 0.31624 | NA | NA |
| CXCR4 | nilotinib | 0.3164078 | 0.8530655 | 0.31641 | NA | NA |
| SMO | nilotinib | 0.3168786 | 0.8533178 | 0.31688 | NA | NA |
| SF3B1 | bosutinib monohydrate | 0.3173562 | 0.8533178 | 0.31736 | NA | NA |
| KIT | rucaparib | 0.3176892 | 0.8533178 | 0.31769 | NA | NA |
| PTCH1 | palbociclib | 0.3180803 | 0.8533178 | 0.31808 | NA | NA |
| RIT1 | crizotinib | 0.3182654 | 0.8533178 | 0.31827 | NA | NA |
| SH2B3 | tretinoin | 0.3183595 | 0.8533178 | 0.31836 | NA | NA |
| MAP2K2 | trametinib | 0.3188070 | 0.8533178 | 0.31881 | NA | NA |
| CBLB | lapatinib | 0.3188445 | 0.8533178 | 0.31884 | NA | NA |
| SMC3 | imatinib | 0.3191465 | 0.8533178 | 0.31915 | NA | NA |
| SMC1A | crizotinib | 0.3195953 | 0.8533178 | 0.31960 | NA | NA |
| ZRSR2 | nilotinib | 0.3197215 | 0.8533178 | 0.31972 | NA | NA |
| NPM1 | nilotinib | 0.3197255 | 0.8533178 | 0.31973 | NA | NA |
| IL7R | pazopanib | 0.3205386 | 0.8544661 | 0.32054 | NA | NA |
| ROS1 | rucaparib | 0.3210092 | 0.8544661 | 0.32101 | NA | NA |
| FBXW7 | lapatinib | 0.3216173 | 0.8544661 | 0.32162 | NA | NA |
| EGF | trametinib | 0.3216768 | 0.8544661 | 0.32168 | NA | NA |
| PIK3CA | nilotinib | 0.3221612 | 0.8544661 | 0.32216 | NA | NA |
| RAD21 | bosutinib monohydrate | 0.3221870 | 0.8544661 | 0.32219 | NA | NA |
| FGFR3 | docetaxel | 0.3221893 | 0.8544661 | 0.32219 | NA | NA |
| CDC73 | bosutinib monohydrate | 0.3226723 | 0.8544661 | 0.32267 | NA | NA |
| TET2 | bosutinib monohydrate | 0.3227747 | 0.8544661 | 0.32277 | NA | NA |
| FGFR3 | lapatinib | 0.3229794 | 0.8544661 | 0.32298 | NA | NA |
| GATA1 | temozolomide | 0.3232634 | 0.8544661 | 0.32326 | NA | NA |
| SF1 | alectinib | 0.3234420 | 0.8544661 | 0.32344 | NA | NA |
| SMC1A | midostaurin | 0.3236533 | 0.8544661 | 0.32365 | NA | NA |
| FGFR2 | midostaurin | 0.3242790 | 0.8554070 | 0.32428 | NA | NA |
| DPYD | vismodegib | 0.3255816 | 0.8580773 | 0.32558 | NA | NA |
| IDH2 | gefitinib | 0.3258316 | 0.8580773 | 0.32583 | NA | NA |
| FLT3 | gefitinib | 0.3274937 | 0.8606691 | 0.32749 | NA | NA |
| CTCF | ponatinib | 0.3280080 | 0.8606691 | 0.32801 | NA | NA |
| MGMT | dabrafenib | 0.3282216 | 0.8606691 | 0.32822 | NA | NA |
| U2AF1 | temozolomide | 0.3282964 | 0.8606691 | 0.32830 | NA | NA |
| PIK3CA | erlotinib | 0.3286540 | 0.8606691 | 0.32865 | NA | NA |
| BCORL1 | palbociclib | 0.3287607 | 0.8606691 | 0.32876 | NA | NA |
| IDH2 | docetaxel | 0.3288933 | 0.8606691 | 0.32889 | NA | NA |
| FLCN | cabozantinib | 0.3290045 | 0.8606691 | 0.32900 | NA | NA |
| SSX1 | alectinib | 0.3293082 | 0.8606691 | 0.32931 | NA | NA |
| MAP2K2 | ruxolitinib | 0.3295676 | 0.8606691 | 0.32957 | NA | NA |
| NOTCH2 | crizotinib | 0.3297967 | 0.8606691 | 0.32980 | NA | NA |
| GNB1 | ponatinib | 0.3304650 | 0.8610009 | 0.33046 | NA | NA |
| PAX5 | lapatinib | 0.3307420 | 0.8610009 | 0.33074 | NA | NA |
| GATA1 | alectinib | 0.3310119 | 0.8610009 | 0.33101 | NA | NA |
| TSC2 | lapatinib | 0.3311360 | 0.8610009 | 0.33114 | NA | NA |
| EGFR | midostaurin | 0.3312793 | 0.8610009 | 0.33128 | NA | NA |
| ERBB2 | nilotinib | 0.3322155 | 0.8615524 | 0.33222 | NA | NA |
| WHSC1 | erlotinib | 0.3322629 | 0.8615524 | 0.33226 | NA | NA |
| PDGFB | palbociclib | 0.3327587 | 0.8615524 | 0.33276 | NA | NA |
| PRPF8 | crizotinib | 0.3336126 | 0.8615524 | 0.33361 | NA | NA |
| PIGA | belinostat | 0.3336508 | 0.8615524 | 0.33365 | NA | NA |
| JAK1 | tretinoin | 0.3338555 | 0.8615524 | 0.33386 | NA | NA |
| ROS1 | nilotinib | 0.3339538 | 0.8615524 | 0.33395 | NA | NA |
| ERBB3 | gefitinib | 0.3353927 | 0.8615524 | 0.33539 | NA | NA |
| AKT2 | crizotinib | 0.3358098 | 0.8615524 | 0.33581 | NA | NA |
| NT5C2 | crizotinib | 0.3358098 | 0.8615524 | 0.33581 | NA | NA |
| CD79B | dasatinib | 0.3359203 | 0.8615524 | 0.33592 | NA | NA |
| GNAQ | dasatinib | 0.3359203 | 0.8615524 | 0.33592 | NA | NA |
| PDCD1 | dasatinib | 0.3359203 | 0.8615524 | 0.33592 | NA | NA |
| IDH1 | rucaparib | 0.3365827 | 0.8615524 | 0.33658 | NA | NA |
| BRAF | imatinib | 0.3365852 | 0.8615524 | 0.33659 | NA | NA |
| SMC3 | ruxolitinib | 0.3368205 | 0.8615524 | 0.33682 | NA | NA |
| SETBP1 | gefitinib | 0.3370540 | 0.8615524 | 0.33705 | NA | NA |
| MET | pazopanib | 0.3375577 | 0.8615524 | 0.33756 | NA | NA |
| ERBB3 | bosutinib monohydrate | 0.3381914 | 0.8615524 | 0.33819 | NA | NA |
| BCORL1 | nilotinib | 0.3383996 | 0.8615524 | 0.33840 | NA | NA |
| MPL | afatinib | 0.3387786 | 0.8615524 | 0.33878 | NA | NA |
| CTCF | erlotinib | 0.3389875 | 0.8615524 | 0.33899 | NA | NA |
| BCOR | temozolomide | 0.3390158 | 0.8615524 | 0.33902 | NA | NA |
| SH2B3 | nilotinib | 0.3391378 | 0.8615524 | 0.33914 | NA | NA |
| GNAS | rucaparib | 0.3392393 | 0.8615524 | 0.33924 | NA | NA |
| SRSF2 | cabozantinib | 0.3392737 | 0.8615524 | 0.33927 | NA | NA |
| RET | vismodegib | 0.3393340 | 0.8615524 | 0.33933 | NA | NA |
| CD274 | vismodegib | 0.3393363 | 0.8615524 | 0.33934 | NA | NA |
| CDK4 | gefitinib | 0.3394024 | 0.8615524 | 0.33940 | NA | NA |
| ERBB2 | pazopanib | 0.3398016 | 0.8615524 | 0.33980 | NA | NA |
| PDGFRB | rucaparib | 0.3399009 | 0.8615524 | 0.33990 | NA | NA |
| CEBPA | bosutinib monohydrate | 0.3405298 | 0.8624581 | 0.34053 | NA | NA |
| IKZF1 | imatinib | 0.3413302 | 0.8633688 | 0.34133 | NA | NA |
| NRAS | ponatinib | 0.3414906 | 0.8633688 | 0.34149 | NA | NA |
| STAG2 | vismodegib | 0.3420418 | 0.8633688 | 0.34204 | NA | NA |
| GNAQ | bosutinib monohydrate | 0.3420516 | 0.8633688 | 0.34205 | NA | NA |
| MYD88 | rucaparib | 0.3422485 | 0.8633688 | 0.34225 | NA | NA |
| PDGFRB | vismodegib | 0.3432087 | 0.8651040 | 0.34321 | NA | NA |
| KMT2A | alectinib | 0.3437441 | 0.8656743 | 0.34374 | NA | NA |
| GNB1 | belinostat | 0.3441703 | 0.8656743 | 0.34417 | NA | NA |
| BTK | tretinoin | 0.3447531 | 0.8656743 | 0.34475 | NA | NA |
| BTK | alectinib | 0.3449044 | 0.8656743 | 0.34490 | NA | NA |
| DPYD | rucaparib | 0.3449122 | 0.8656743 | 0.34491 | NA | NA |
| DPYD | dasatinib | 0.3450704 | 0.8656743 | 0.34507 | NA | NA |
| WHSC1 | nilotinib | 0.3455546 | 0.8662048 | 0.34555 | NA | NA |
| RAD21 | pazopanib | 0.3462781 | 0.8673337 | 0.34628 | NA | NA |
| CTCF | belinostat | 0.3467750 | 0.8677536 | 0.34678 | NA | NA |
| NCOA2 | nilotinib | 0.3469922 | 0.8677536 | 0.34699 | NA | NA |
| BRCA1 | alectinib | 0.3475727 | 0.8678703 | 0.34757 | NA | NA |
| MET | bosutinib monohydrate | 0.3480988 | 0.8678703 | 0.34810 | NA | NA |
| SF1 | erlotinib | 0.3481404 | 0.8678703 | 0.34814 | NA | NA |
| IDH2 | tretinoin | 0.3482943 | 0.8678703 | 0.34829 | NA | NA |
| ATM | temozolomide | 0.3484051 | 0.8678703 | 0.34841 | NA | NA |
| AR | trametinib | 0.3489364 | 0.8685125 | 0.34894 | NA | NA |
| EZH2 | belinostat | 0.3495023 | 0.8690733 | 0.34950 | NA | NA |
| EGF | dasatinib | 0.3499723 | 0.8690733 | 0.34997 | NA | NA |
| BRCA2 | belinostat | 0.3501637 | 0.8690733 | 0.35016 | NA | NA |
| PRPF8 | gefitinib | 0.3503421 | 0.8690733 | 0.35034 | NA | NA |
| PTPN11 | docetaxel | 0.3505582 | 0.8690733 | 0.35056 | NA | NA |
| CDK4 | docetaxel | 0.3512258 | 0.8690733 | 0.35123 | NA | NA |
| GATA1 | dasatinib | 0.3512636 | 0.8690733 | 0.35126 | NA | NA |
| NRAS | crizotinib | 0.3513508 | 0.8690733 | 0.35135 | NA | NA |
| CEBPA | trametinib | 0.3520319 | 0.8700805 | 0.35203 | NA | NA |
| GATA1 | pazopanib | 0.3523703 | 0.8702394 | 0.35237 | NA | NA |
| EGF | nilotinib | 0.3526555 | 0.8702671 | 0.35266 | NA | NA |
| SMC3 | palbociclib | 0.3538314 | 0.8719506 | 0.35383 | NA | NA |
| CDK4 | dabrafenib | 0.3540843 | 0.8719506 | 0.35408 | NA | NA |
| STAG2 | bosutinib monohydrate | 0.3541613 | 0.8719506 | 0.35416 | NA | NA |
| SETD2 | nilotinib | 0.3549033 | 0.8725188 | 0.35490 | NA | NA |
| TET2 | gefitinib | 0.3552137 | 0.8725188 | 0.35521 | NA | NA |
| PDCD1 | erlotinib | 0.3556069 | 0.8725188 | 0.35561 | NA | NA |
| G6PD | ponatinib | 0.3562978 | 0.8725188 | 0.35630 | NA | NA |
| GATA1 | rucaparib | 0.3564121 | 0.8725188 | 0.35641 | NA | NA |
| CYP19A1 | alectinib | 0.3564980 | 0.8725188 | 0.35650 | NA | NA |
| CBL | nilotinib | 0.3567703 | 0.8725188 | 0.35677 | NA | NA |
| PIGA | crizotinib | 0.3571747 | 0.8725188 | 0.35717 | NA | NA |
| DNMT3A | vismodegib | 0.3575484 | 0.8725188 | 0.35755 | NA | NA |
| ERBB4 | trametinib | 0.3576230 | 0.8725188 | 0.35762 | NA | NA |
| PTCH1 | docetaxel | 0.3578141 | 0.8725188 | 0.35781 | NA | NA |
| BRAF | nilotinib | 0.3579029 | 0.8725188 | 0.35790 | NA | NA |
| KIT | afatinib | 0.3580267 | 0.8725188 | 0.35803 | NA | NA |
| IKZF1 | erlotinib | 0.3582382 | 0.8725188 | 0.35824 | NA | NA |
| SETBP1 | afatinib | 0.3588256 | 0.8728730 | 0.35883 | NA | NA |
| MET | sunitinib | 0.3589333 | 0.8728730 | 0.35893 | NA | NA |
| BRAF | pazopanib | 0.3592410 | 0.8729529 | 0.35924 | NA | NA |
| GATA2 | cabozantinib | 0.3602779 | 0.8746924 | 0.36028 | NA | NA |
| KMT2A | imatinib | 0.3610200 | 0.8746924 | 0.36102 | NA | NA |
| TP53 | nilotinib | 0.3614059 | 0.8746924 | 0.36141 | NA | NA |
| MDM2 | sunitinib | 0.3616422 | 0.8746924 | 0.36164 | NA | NA |
| MPL | rucaparib | 0.3616444 | 0.8746924 | 0.36164 | NA | NA |
| AKT3 | ponatinib | 0.3621735 | 0.8746924 | 0.36217 | NA | NA |
| CXCR4 | afatinib | 0.3626374 | 0.8746924 | 0.36264 | NA | NA |
| STAG2 | crizotinib | 0.3627363 | 0.8746924 | 0.36274 | NA | NA |
| PDGFB | gefitinib | 0.3627861 | 0.8746924 | 0.36279 | NA | NA |
| BRCA2 | pazopanib | 0.3630866 | 0.8746924 | 0.36309 | NA | NA |
| PAX5 | vismodegib | 0.3631253 | 0.8746924 | 0.36313 | NA | NA |
| PAX5 | dasatinib | 0.3632617 | 0.8746924 | 0.36326 | NA | NA |
| AR | cabozantinib | 0.3642750 | 0.8754019 | 0.36427 | NA | NA |
| SSX1 | gefitinib | 0.3647486 | 0.8754019 | 0.36475 | NA | NA |
| AKT3 | lapatinib | 0.3649345 | 0.8754019 | 0.36493 | NA | NA |
| IDH1 | lapatinib | 0.3649345 | 0.8754019 | 0.36493 | NA | NA |
| MYCN | lapatinib | 0.3649345 | 0.8754019 | 0.36493 | NA | NA |
| XPO1 | erlotinib | 0.3661029 | 0.8770653 | 0.36610 | NA | NA |
| IKZF1 | crizotinib | 0.3663689 | 0.8770653 | 0.36637 | NA | NA |
| CTCF | alectinib | 0.3665010 | 0.8770653 | 0.36650 | NA | NA |
| BCOR | vismodegib | 0.3669291 | 0.8770653 | 0.36693 | NA | NA |
| PDGFRB | lapatinib | 0.3673411 | 0.8770653 | 0.36734 | NA | NA |
| TSC1 | lapatinib | 0.3673411 | 0.8770653 | 0.36734 | NA | NA |
| PTEN | crizotinib | 0.3676751 | 0.8770653 | 0.36768 | NA | NA |
| MAP2K2 | dabrafenib | 0.3682429 | 0.8770653 | 0.36824 | NA | NA |
| CDKN2A | temozolomide | 0.3683127 | 0.8770653 | 0.36831 | NA | NA |
| TSC1 | pazopanib | 0.3683895 | 0.8770653 | 0.36839 | NA | NA |
| XPO1 | sunitinib | 0.3697335 | 0.8794232 | 0.36973 | NA | NA |
| ALK | crizotinib | 0.3700920 | 0.8794232 | 0.37009 | NA | NA |
| ATM | nilotinib | 0.3703913 | 0.8794232 | 0.37039 | NA | NA |
| TSC1 | palbociclib | 0.3704875 | 0.8794232 | 0.37049 | NA | NA |
| ASXL1 | ruxolitinib | 0.3708094 | 0.8795300 | 0.37081 | NA | NA |
| FANCL | afatinib | 0.3712677 | 0.8796559 | 0.37127 | NA | NA |
| NPM1 | crizotinib | 0.3719543 | 0.8796559 | 0.37195 | NA | NA |
| RUNX1 | trametinib | 0.3720382 | 0.8796559 | 0.37204 | NA | NA |
| BCORL1 | docetaxel | 0.3721966 | 0.8796559 | 0.37220 | NA | NA |
| FGFR2 | crizotinib | 0.3724916 | 0.8796559 | 0.37249 | NA | NA |
| SMO | palbociclib | 0.3726724 | 0.8796559 | 0.37267 | NA | NA |
| G6PD | palbociclib | 0.3728013 | 0.8796559 | 0.37280 | NA | NA |
| SH2B3 | midostaurin | 0.3733494 | 0.8801498 | 0.37335 | NA | NA |
| SF1 | afatinib | 0.3735649 | 0.8801498 | 0.37356 | NA | NA |
| PRPF40B | trametinib | 0.3750237 | 0.8829320 | 0.37502 | NA | NA |
| PIGA | trametinib | 0.3753941 | 0.8830149 | 0.37539 | NA | NA |
| ATM | lapatinib | 0.3757531 | 0.8830149 | 0.37575 | NA | NA |
| ASXL1 | afatinib | 0.3758930 | 0.8830149 | 0.37589 | NA | NA |
| SRSF2 | rucaparib | 0.3768031 | 0.8838700 | 0.37680 | NA | NA |
| SF1 | dasatinib | 0.3774403 | 0.8838700 | 0.37744 | NA | NA |
| RIT1 | tretinoin | 0.3778288 | 0.8838700 | 0.37783 | NA | NA |
| NCOA2 | dabrafenib | 0.3782220 | 0.8838700 | 0.37822 | NA | NA |
| ERBB2 | ruxolitinib | 0.3785733 | 0.8838700 | 0.37857 | NA | NA |
| IL7R | belinostat | 0.3785808 | 0.8838700 | 0.37858 | NA | NA |
| MAP2K1 | cabozantinib | 0.3789920 | 0.8838700 | 0.37899 | NA | NA |
| PDGFB | dasatinib | 0.3792939 | 0.8838700 | 0.37929 | NA | NA |
| GNA11 | gefitinib | 0.3799164 | 0.8838700 | 0.37992 | NA | NA |
| MPL | tretinoin | 0.3802579 | 0.8838700 | 0.38026 | NA | NA |
| KRAS | dasatinib | 0.3806744 | 0.8838700 | 0.38067 | NA | NA |
| BCORL1 | dasatinib | 0.3812942 | 0.8838700 | 0.38129 | NA | NA |
| NPM1 | bosutinib monohydrate | 0.3813570 | 0.8838700 | 0.38136 | NA | NA |
| SMO | afatinib | 0.3813865 | 0.8838700 | 0.38139 | NA | NA |
| STAG2 | midostaurin | 0.3813979 | 0.8838700 | 0.38140 | NA | NA |
| MDM2 | ponatinib | 0.3814458 | 0.8838700 | 0.38145 | NA | NA |
| PAX5 | docetaxel | 0.3815151 | 0.8838700 | 0.38152 | NA | NA |
| G6PD | nilotinib | 0.3817505 | 0.8838700 | 0.38175 | NA | NA |
| WHSC1 | imatinib | 0.3820492 | 0.8838700 | 0.38205 | NA | NA |
| DPYD | temozolomide | 0.3822258 | 0.8838700 | 0.38223 | NA | NA |
| MDM2 | temozolomide | 0.3822745 | 0.8838700 | 0.38227 | NA | NA |
| ATM | pazopanib | 0.3827853 | 0.8838700 | 0.38279 | NA | NA |
| ERBB2 | bosutinib monohydrate | 0.3828642 | 0.8838700 | 0.38286 | NA | NA |
| AKT3 | sunitinib | 0.3829361 | 0.8838700 | 0.38294 | NA | NA |
| PTCH1 | alectinib | 0.3832319 | 0.8839104 | 0.38323 | NA | NA |
| PIK3CA | dasatinib | 0.3837150 | 0.8843823 | 0.38371 | NA | NA |
| CXCR4 | ruxolitinib | 0.3846942 | 0.8857204 | 0.38469 | NA | NA |
| BRCA2 | gefitinib | 0.3852457 | 0.8857204 | 0.38525 | NA | NA |
| MDM2 | bosutinib monohydrate | 0.3854602 | 0.8857204 | 0.38546 | NA | NA |
| FGFR3 | vismodegib | 0.3855608 | 0.8857204 | 0.38556 | NA | NA |
| IKZF1 | vismodegib | 0.3859382 | 0.8857204 | 0.38594 | NA | NA |
| ATM | afatinib | 0.3862525 | 0.8857204 | 0.38625 | NA | NA |
| CDK6 | erlotinib | 0.3864721 | 0.8857204 | 0.38647 | NA | NA |
| AR | midostaurin | 0.3869180 | 0.8857204 | 0.38692 | NA | NA |
| PAX8 | alectinib | 0.3871065 | 0.8857204 | 0.38711 | NA | NA |
| CSF3R | crizotinib | 0.3873438 | 0.8857204 | 0.38734 | NA | NA |
| RAD21 | sunitinib | 0.3873632 | 0.8857204 | 0.38736 | NA | NA |
| CTCF | nilotinib | 0.3876743 | 0.8857940 | 0.38767 | NA | NA |
| RET | imatinib | 0.3884249 | 0.8865142 | 0.38842 | NA | NA |
| DNAJB1 | pazopanib | 0.3887892 | 0.8865142 | 0.38879 | NA | NA |
| SMO | imatinib | 0.3890402 | 0.8865142 | 0.38904 | NA | NA |
| ERBB3 | belinostat | 0.3891061 | 0.8865142 | 0.38911 | NA | NA |
| WT1 | dabrafenib | 0.3899972 | 0.8869513 | 0.39000 | NA | NA |
| SETBP1 | ponatinib | 0.3902213 | 0.8869513 | 0.39022 | NA | NA |
| BCORL1 | sunitinib | 0.3905032 | 0.8869513 | 0.39050 | NA | NA |
| CTCF | dabrafenib | 0.3923327 | 0.8869513 | 0.39233 | NA | NA |
| FGFR1 | sunitinib | 0.3924162 | 0.8869513 | 0.39242 | NA | NA |
| BRCA1 | dasatinib | 0.3928660 | 0.8869513 | 0.39287 | NA | NA |
| PHF6 | lapatinib | 0.3938211 | 0.8869513 | 0.39382 | NA | NA |
| ESR1 | vismodegib | 0.3942862 | 0.8869513 | 0.39429 | NA | NA |
| AKT3 | erlotinib | 0.3944367 | 0.8869513 | 0.39444 | NA | NA |
| IDH1 | erlotinib | 0.3944367 | 0.8869513 | 0.39444 | NA | NA |
| MYCN | erlotinib | 0.3944367 | 0.8869513 | 0.39444 | NA | NA |
| U2AF1 | erlotinib | 0.3944367 | 0.8869513 | 0.39444 | NA | NA |
| AKT1 | tretinoin | 0.3944562 | 0.8869513 | 0.39446 | NA | NA |
| ALK | dasatinib | 0.3952274 | 0.8869513 | 0.39523 | NA | NA |
| BTK | gefitinib | 0.3953704 | 0.8869513 | 0.39537 | NA | NA |
| TSC1 | alectinib | 0.3956481 | 0.8869513 | 0.39565 | NA | NA |
| DNAJB1 | gefitinib | 0.3961625 | 0.8869513 | 0.39616 | NA | NA |
| AKT1 | palbociclib | 0.3961746 | 0.8869513 | 0.39617 | NA | NA |
| PTEN | vismodegib | 0.3964159 | 0.8869513 | 0.39642 | NA | NA |
| GATA1 | nilotinib | 0.3965339 | 0.8869513 | 0.39653 | NA | NA |
| CYP19A1 | nilotinib | 0.3966596 | 0.8869513 | 0.39666 | NA | NA |
| SMC1A | cabozantinib | 0.3971299 | 0.8869513 | 0.39713 | NA | NA |
| DDIT3 | belinostat | 0.3972274 | 0.8869513 | 0.39723 | NA | NA |
| MET | gefitinib | 0.3977576 | 0.8869513 | 0.39776 | NA | NA |
| ASXL1 | erlotinib | 0.3979892 | 0.8869513 | 0.39799 | NA | NA |
| IL7R | bosutinib monohydrate | 0.3981162 | 0.8869513 | 0.39812 | NA | NA |
| WT1 | tretinoin | 0.3981599 | 0.8869513 | 0.39816 | NA | NA |
| JAK3 | gefitinib | 0.3982969 | 0.8869513 | 0.39830 | NA | NA |
| UGT1A1 | pazopanib | 0.3984406 | 0.8869513 | 0.39844 | NA | NA |
| JAK3 | tretinoin | 0.3985742 | 0.8869513 | 0.39857 | NA | NA |
| SF1 | nilotinib | 0.3986195 | 0.8869513 | 0.39862 | NA | NA |
| RUNX1 | ponatinib | 0.3986659 | 0.8869513 | 0.39867 | NA | NA |
| IKZF1 | trametinib | 0.3988024 | 0.8869513 | 0.39880 | NA | NA |
| DDIT3 | trametinib | 0.3990678 | 0.8869513 | 0.39907 | NA | NA |
| UGT1A1 | sunitinib | 0.3992388 | 0.8869513 | 0.39924 | NA | NA |
| STAG2 | afatinib | 0.3995949 | 0.8869513 | 0.39959 | NA | NA |
| NPM1 | palbociclib | 0.3996308 | 0.8869513 | 0.39963 | NA | NA |
| AKT2 | docetaxel | 0.4005242 | 0.8874480 | 0.40052 | NA | NA |
| ALK | temozolomide | 0.4005886 | 0.8874480 | 0.40059 | NA | NA |
| KIT | erlotinib | 0.4010455 | 0.8874480 | 0.40105 | NA | NA |
| IDH2 | crizotinib | 0.4011464 | 0.8874480 | 0.40115 | NA | NA |
| PDCD1 | lapatinib | 0.4012535 | 0.8874480 | 0.40125 | NA | NA |
| PDGFRA | rucaparib | 0.4016231 | 0.8874480 | 0.40162 | NA | NA |
| FGFR1 | temozolomide | 0.4020141 | 0.8874480 | 0.40201 | NA | NA |
| SETD2 | lapatinib | 0.4021077 | 0.8874480 | 0.40211 | NA | NA |
| AKT2 | alectinib | 0.4024812 | 0.8874480 | 0.40248 | NA | NA |
| ATM | imatinib | 0.4026488 | 0.8874480 | 0.40265 | NA | NA |
| BCORL1 | cabozantinib | 0.4040076 | 0.8888187 | 0.40401 | NA | NA |
| ERBB4 | alectinib | 0.4041032 | 0.8888187 | 0.40410 | NA | NA |
| UGT1A1 | belinostat | 0.4041103 | 0.8888187 | 0.40411 | NA | NA |
| BRCA1 | erlotinib | 0.4046403 | 0.8893687 | 0.40464 | NA | NA |
| EZH2 | gefitinib | 0.4053278 | 0.8900186 | 0.40533 | NA | NA |
| TP53 | imatinib | 0.4057119 | 0.8900186 | 0.40571 | NA | NA |
| PDGFB | docetaxel | 0.4060325 | 0.8900186 | 0.40603 | NA | NA |
| VHL | nilotinib | 0.4061768 | 0.8900186 | 0.40618 | NA | NA |
| CTNNB1 | trametinib | 0.4064703 | 0.8900186 | 0.40647 | NA | NA |
| PIK3CA | belinostat | 0.4072121 | 0.8900186 | 0.40721 | NA | NA |
| RUNX1 | nilotinib | 0.4072745 | 0.8900186 | 0.40727 | NA | NA |
| WT1 | palbociclib | 0.4072870 | 0.8900186 | 0.40729 | NA | NA |
| CD274 | tretinoin | 0.4075623 | 0.8900186 | 0.40756 | NA | NA |
| PML | tretinoin | 0.4081601 | 0.8900186 | 0.40816 | NA | NA |
| DNMT3A | ruxolitinib | 0.4082055 | 0.8900186 | 0.40821 | NA | NA |
| PDGFRA | palbociclib | 0.4083491 | 0.8900186 | 0.40835 | NA | NA |
| JAK3 | dabrafenib | 0.4085791 | 0.8900186 | 0.40858 | NA | NA |
| DDIT3 | ponatinib | 0.4091577 | 0.8906682 | 0.40916 | NA | NA |
| ASXL1 | cabozantinib | 0.4107168 | 0.8921233 | 0.41072 | NA | NA |
| IDH2 | trametinib | 0.4108540 | 0.8921233 | 0.41085 | NA | NA |
| SMO | ruxolitinib | 0.4108655 | 0.8921233 | 0.41087 | NA | NA |
| GATA3 | vismodegib | 0.4109497 | 0.8921233 | 0.41095 | NA | NA |
| NOTCH2 | ruxolitinib | 0.4112888 | 0.8922494 | 0.41129 | NA | NA |
| TP53 | vismodegib | 0.4116935 | 0.8925177 | 0.41169 | NA | NA |
| CEBPA | afatinib | 0.4120008 | 0.8925747 | 0.41200 | NA | NA |
| FGFR3 | crizotinib | 0.4127192 | 0.8927858 | 0.41272 | NA | NA |
| RET | lapatinib | 0.4130391 | 0.8927858 | 0.41304 | NA | NA |
| PIK3CA | sunitinib | 0.4133331 | 0.8927858 | 0.41333 | NA | NA |
| ASXL1 | gefitinib | 0.4134771 | 0.8927858 | 0.41348 | NA | NA |
| WHSC1 | ponatinib | 0.4135038 | 0.8927858 | 0.41350 | NA | NA |
| FLCN | dasatinib | 0.4143515 | 0.8935561 | 0.41435 | NA | NA |
| RIT1 | vismodegib | 0.4144232 | 0.8935561 | 0.41442 | NA | NA |
| CDC73 | cabozantinib | 0.4149638 | 0.8941147 | 0.41496 | NA | NA |
| FGFR3 | dabrafenib | 0.4155330 | 0.8946143 | 0.41553 | NA | NA |
| BRCA1 | trametinib | 0.4159320 | 0.8946143 | 0.41593 | NA | NA |
| EML4 | ponatinib | 0.4160407 | 0.8946143 | 0.41604 | NA | NA |
| DNMT3A | trametinib | 0.4166812 | 0.8948884 | 0.41668 | NA | NA |
| PDCD1 | pazopanib | 0.4167317 | 0.8948884 | 0.41673 | NA | NA |
| BTK | ponatinib | 0.4171885 | 0.8952639 | 0.41719 | NA | NA |
| PDGFRA | bosutinib monohydrate | 0.4175132 | 0.8953557 | 0.41751 | NA | NA |
| IKZF1 | docetaxel | 0.4191295 | 0.8982155 | 0.41913 | NA | NA |
| GNA11 | nilotinib | 0.4200233 | 0.8992814 | 0.42002 | NA | NA |
| MDM2 | trametinib | 0.4203066 | 0.8992814 | 0.42031 | NA | NA |
| PTPN11 | palbociclib | 0.4211924 | 0.8992814 | 0.42119 | NA | NA |
| BCOR | gefitinib | 0.4214414 | 0.8992814 | 0.42144 | NA | NA |
| ZRSR2 | bosutinib monohydrate | 0.4214919 | 0.8992814 | 0.42149 | NA | NA |
| MYD88 | alectinib | 0.4215902 | 0.8992814 | 0.42159 | NA | NA |
| AKT3 | cabozantinib | 0.4216866 | 0.8992814 | 0.42169 | NA | NA |
| ASXL1 | bosutinib monohydrate | 0.4226760 | 0.8992814 | 0.42268 | NA | NA |
| SMC3 | belinostat | 0.4229260 | 0.8992814 | 0.42293 | NA | NA |
| BRCA1 | nilotinib | 0.4230452 | 0.8992814 | 0.42305 | NA | NA |
| PRPF40B | belinostat | 0.4230525 | 0.8992814 | 0.42305 | NA | NA |
| BCORL1 | gefitinib | 0.4232724 | 0.8992814 | 0.42327 | NA | NA |
| MPL | ponatinib | 0.4233079 | 0.8992814 | 0.42331 | NA | NA |
| JAK2 | belinostat | 0.4239919 | 0.8994253 | 0.42399 | NA | NA |
| FBXW7 | docetaxel | 0.4241498 | 0.8994253 | 0.42415 | NA | NA |
| SRSF2 | ruxolitinib | 0.4243256 | 0.8994253 | 0.42433 | NA | NA |
| ASXL1 | belinostat | 0.4246638 | 0.8994253 | 0.42466 | NA | NA |
| PIGA | cabozantinib | 0.4249891 | 0.8994253 | 0.42499 | NA | NA |
| ABL1 | dasatinib | 0.4250747 | 0.8994253 | 0.42507 | NA | NA |
| ESR1 | docetaxel | 0.4254686 | 0.8996594 | 0.42547 | NA | NA |
| CBL | vismodegib | 0.4259523 | 0.8997855 | 0.42595 | NA | NA |
| CDK6 | temozolomide | 0.4260949 | 0.8997855 | 0.42609 | NA | NA |
| KMT2A | nilotinib | 0.4270492 | 0.9012015 | 0.42705 | NA | NA |
| AR | gefitinib | 0.4279563 | 0.9025160 | 0.42796 | NA | NA |
| PAX8 | afatinib | 0.4284981 | 0.9025462 | 0.42850 | NA | NA |
| ERBB2 | erlotinib | 0.4285389 | 0.9025462 | 0.42854 | NA | NA |
| SETD2 | ponatinib | 0.4289630 | 0.9028405 | 0.42896 | NA | NA |
| CD274 | pazopanib | 0.4298527 | 0.9033401 | 0.42985 | NA | NA |
| KMT2A | erlotinib | 0.4299866 | 0.9033401 | 0.42999 | NA | NA |
| KIT | gefitinib | 0.4300536 | 0.9033401 | 0.43005 | NA | NA |
| JAK1 | pazopanib | 0.4308861 | 0.9044755 | 0.43089 | NA | NA |
| BRCA1 | ponatinib | 0.4319743 | 0.9044755 | 0.43197 | NA | NA |
| PRPF8 | tretinoin | 0.4328990 | 0.9044755 | 0.43290 | NA | NA |
| SMC1A | alectinib | 0.4329711 | 0.9044755 | 0.43297 | NA | NA |
| NOTCH2 | vismodegib | 0.4329752 | 0.9044755 | 0.43298 | NA | NA |
| UGT1A1 | dasatinib | 0.4335809 | 0.9044755 | 0.43358 | NA | NA |
| PRPF8 | imatinib | 0.4337483 | 0.9044755 | 0.43375 | NA | NA |
| PDCD1 | afatinib | 0.4342385 | 0.9044755 | 0.43424 | NA | NA |
| PTPN11 | nilotinib | 0.4343504 | 0.9044755 | 0.43435 | NA | NA |
| BTK | erlotinib | 0.4357267 | 0.9044755 | 0.43573 | NA | NA |
| ZRSR2 | alectinib | 0.4359432 | 0.9044755 | 0.43594 | NA | NA |
| FLCN | gefitinib | 0.4366833 | 0.9044755 | 0.43668 | NA | NA |
| AR | sunitinib | 0.4370527 | 0.9044755 | 0.43705 | NA | NA |
| PDGFB | temozolomide | 0.4372281 | 0.9044755 | 0.43723 | NA | NA |
| NRAS | nilotinib | 0.4375929 | 0.9044755 | 0.43759 | NA | NA |
| CXCR4 | bosutinib monohydrate | 0.4378881 | 0.9044755 | 0.43789 | NA | NA |
| MPL | dabrafenib | 0.4381599 | 0.9044755 | 0.43816 | NA | NA |
| DNMT3A | imatinib | 0.4384088 | 0.9044755 | 0.43841 | NA | NA |
| CTCF | midostaurin | 0.4387679 | 0.9044755 | 0.43877 | NA | NA |
| SMC1A | vismodegib | 0.4388743 | 0.9044755 | 0.43887 | NA | NA |
| STAG2 | dabrafenib | 0.4388822 | 0.9044755 | 0.43888 | NA | NA |
| MYCN | rucaparib | 0.4390214 | 0.9044755 | 0.43902 | NA | NA |
| ASXL1 | crizotinib | 0.4390544 | 0.9044755 | 0.43905 | NA | NA |
| GNB1 | palbociclib | 0.4395108 | 0.9044755 | 0.43951 | NA | NA |
| NOTCH2 | cabozantinib | 0.4395724 | 0.9044755 | 0.43957 | NA | NA |
| FLT3 | temozolomide | 0.4398840 | 0.9044755 | 0.43988 | NA | NA |
| IDH2 | lapatinib | 0.4399819 | 0.9044755 | 0.43998 | NA | NA |
| CYP19A1 | midostaurin | 0.4400719 | 0.9044755 | 0.44007 | NA | NA |
| TP53 | midostaurin | 0.4402169 | 0.9044755 | 0.44022 | NA | NA |
| GATA3 | dasatinib | 0.4405211 | 0.9044755 | 0.44052 | NA | NA |
| XPO1 | rucaparib | 0.4406168 | 0.9044755 | 0.44062 | NA | NA |
| RAD21 | dasatinib | 0.4407374 | 0.9044755 | 0.44074 | NA | NA |
| SETD2 | bosutinib monohydrate | 0.4409242 | 0.9044755 | 0.44092 | NA | NA |
| ABL1 | rucaparib | 0.4411690 | 0.9044755 | 0.44117 | NA | NA |
| U2AF1 | bosutinib monohydrate | 0.4415049 | 0.9044755 | 0.44150 | NA | NA |
| ABL1 | dabrafenib | 0.4415642 | 0.9044755 | 0.44156 | NA | NA |
| IKZF1 | gefitinib | 0.4416698 | 0.9044755 | 0.44167 | NA | NA |
| KIT | lapatinib | 0.4421047 | 0.9044755 | 0.44210 | NA | NA |
| FLT3 | pazopanib | 0.4421181 | 0.9044755 | 0.44212 | NA | NA |
| NRAS | vismodegib | 0.4423058 | 0.9044755 | 0.44231 | NA | NA |
| IKZF1 | dabrafenib | 0.4423625 | 0.9044755 | 0.44236 | NA | NA |
| TSC2 | pazopanib | 0.4425985 | 0.9044755 | 0.44260 | NA | NA |
| ASXL1 | dabrafenib | 0.4430462 | 0.9044755 | 0.44305 | NA | NA |
| GNAS | palbociclib | 0.4431247 | 0.9044755 | 0.44312 | NA | NA |
| SSX1 | tretinoin | 0.4437195 | 0.9051079 | 0.44372 | NA | NA |
| NT5C2 | docetaxel | 0.4447563 | 0.9064968 | 0.44476 | NA | NA |
| CRLF2 | belinostat | 0.4451357 | 0.9064968 | 0.44514 | NA | NA |
| MYD88 | nilotinib | 0.4453090 | 0.9064968 | 0.44531 | NA | NA |
| ERBB2 | alectinib | 0.4455420 | 0.9064968 | 0.44554 | NA | NA |
| IDH1 | palbociclib | 0.4458469 | 0.9065179 | 0.44585 | NA | NA |
| GATA1 | ruxolitinib | 0.4461233 | 0.9065179 | 0.44612 | NA | NA |
| ERBB4 | belinostat | 0.4469217 | 0.9068658 | 0.44692 | NA | NA |
| GATA2 | pazopanib | 0.4469603 | 0.9068658 | 0.44696 | NA | NA |
| CTCF | trametinib | 0.4472654 | 0.9068658 | 0.44727 | NA | NA |
| GNA11 | palbociclib | 0.4475585 | 0.9068658 | 0.44756 | NA | NA |
| ZRSR2 | temozolomide | 0.4480301 | 0.9068658 | 0.44803 | NA | NA |
| ESR1 | crizotinib | 0.4487601 | 0.9068658 | 0.44876 | NA | NA |
| STAT3 | crizotinib | 0.4489323 | 0.9068658 | 0.44893 | NA | NA |
| AKT1 | dabrafenib | 0.4490980 | 0.9068658 | 0.44910 | NA | NA |
| STAG2 | gefitinib | 0.4492901 | 0.9068658 | 0.44929 | NA | NA |
| EGF | ruxolitinib | 0.4493943 | 0.9068658 | 0.44939 | NA | NA |
| BCOR | ruxolitinib | 0.4496662 | 0.9068658 | 0.44967 | NA | NA |
| PDGFRA | dabrafenib | 0.4498286 | 0.9068658 | 0.44983 | NA | NA |
| ATM | vismodegib | 0.4500064 | 0.9068658 | 0.45001 | NA | NA |
| SF1 | ruxolitinib | 0.4512242 | 0.9070551 | 0.45122 | NA | NA |
| RET | afatinib | 0.4515995 | 0.9070551 | 0.45160 | NA | NA |
| SF1 | palbociclib | 0.4523993 | 0.9070551 | 0.45240 | NA | NA |
| MAP2K2 | pazopanib | 0.4524699 | 0.9070551 | 0.45247 | NA | NA |
| GNA11 | cabozantinib | 0.4525437 | 0.9070551 | 0.45254 | NA | NA |
| G6PD | tretinoin | 0.4531080 | 0.9070551 | 0.45311 | NA | NA |
| CD79B | ponatinib | 0.4546022 | 0.9070551 | 0.45460 | NA | NA |
| CYP19A1 | dasatinib | 0.4547296 | 0.9070551 | 0.45473 | NA | NA |
| VHL | tretinoin | 0.4556069 | 0.9070551 | 0.45561 | NA | NA |
| PML | bosutinib monohydrate | 0.4556704 | 0.9070551 | 0.45567 | NA | NA |
| FGFR3 | cabozantinib | 0.4557661 | 0.9070551 | 0.45577 | NA | NA |
| ETV6 | dabrafenib | 0.4562090 | 0.9070551 | 0.45621 | NA | NA |
| CD274 | nilotinib | 0.4563967 | 0.9070551 | 0.45640 | NA | NA |
| KRAS | vismodegib | 0.4564329 | 0.9070551 | 0.45643 | NA | NA |
| MYCN | ponatinib | 0.4565739 | 0.9070551 | 0.45657 | NA | NA |
| CSF3R | dasatinib | 0.4567258 | 0.9070551 | 0.45673 | NA | NA |
| IDH1 | imatinib | 0.4567885 | 0.9070551 | 0.45679 | NA | NA |
| MYCN | imatinib | 0.4567885 | 0.9070551 | 0.45679 | NA | NA |
| HRAS | trametinib | 0.4570029 | 0.9070551 | 0.45700 | NA | NA |
| CDKN2A | dabrafenib | 0.4571153 | 0.9070551 | 0.45712 | NA | NA |
| PDGFB | alectinib | 0.4572960 | 0.9070551 | 0.45730 | NA | NA |
| DDIT3 | ruxolitinib | 0.4573678 | 0.9070551 | 0.45737 | NA | NA |
| SRSF2 | docetaxel | 0.4573914 | 0.9070551 | 0.45739 | NA | NA |
| MPL | bosutinib monohydrate | 0.4577383 | 0.9070551 | 0.45774 | NA | NA |
| MPL | dasatinib | 0.4578876 | 0.9070551 | 0.45789 | NA | NA |
| CYP19A1 | erlotinib | 0.4583847 | 0.9070551 | 0.45838 | NA | NA |
| BTK | docetaxel | 0.4588269 | 0.9070551 | 0.45883 | NA | NA |
| MYD88 | temozolomide | 0.4590388 | 0.9070551 | 0.45904 | NA | NA |
| NOTCH2 | lapatinib | 0.4590405 | 0.9070551 | 0.45904 | NA | NA |
| EGFR | afatinib | 0.4594260 | 0.9070551 | 0.45943 | NA | NA |
| DPYD | bosutinib monohydrate | 0.4594664 | 0.9070551 | 0.45947 | NA | NA |
| CSF3R | palbociclib | 0.4595627 | 0.9070551 | 0.45956 | NA | NA |
| KIT | temozolomide | 0.4596217 | 0.9070551 | 0.45962 | NA | NA |
| IKZF1 | sunitinib | 0.4601764 | 0.9070551 | 0.46018 | NA | NA |
| PAX8 | gefitinib | 0.4607206 | 0.9070551 | 0.46072 | NA | NA |
| PML | imatinib | 0.4608455 | 0.9070551 | 0.46085 | NA | NA |
| JAK2 | nilotinib | 0.4609294 | 0.9070551 | 0.46093 | NA | NA |
| IDH1 | dasatinib | 0.4613506 | 0.9070551 | 0.46135 | NA | NA |
| MYCN | dasatinib | 0.4613506 | 0.9070551 | 0.46135 | NA | NA |
| DNMT3A | erlotinib | 0.4620527 | 0.9070551 | 0.46205 | NA | NA |
| MET | nilotinib | 0.4620552 | 0.9070551 | 0.46206 | NA | NA |
| FGFR2 | belinostat | 0.4626400 | 0.9070551 | 0.46264 | NA | NA |
| U2AF1 | crizotinib | 0.4627036 | 0.9070551 | 0.46270 | NA | NA |
| XPO1 | bosutinib monohydrate | 0.4627645 | 0.9070551 | 0.46276 | NA | NA |
| CTNNB1 | lapatinib | 0.4631151 | 0.9070551 | 0.46312 | NA | NA |
| FGFR1 | pazopanib | 0.4634379 | 0.9070551 | 0.46344 | NA | NA |
| EML4 | nilotinib | 0.4635234 | 0.9070551 | 0.46352 | NA | NA |
| TET2 | alectinib | 0.4641646 | 0.9071261 | 0.46416 | NA | NA |
| SF3B1 | dasatinib | 0.4651305 | 0.9071261 | 0.46513 | NA | NA |
| FGFR1 | belinostat | 0.4651801 | 0.9071261 | 0.46518 | NA | NA |
| BRCA1 | belinostat | 0.4653768 | 0.9071261 | 0.46538 | NA | NA |
| XPO1 | alectinib | 0.4657556 | 0.9071261 | 0.46576 | NA | NA |
| JAK1 | sunitinib | 0.4658224 | 0.9071261 | 0.46582 | NA | NA |
| PAX8 | ponatinib | 0.4661236 | 0.9071261 | 0.46612 | NA | NA |
| TP53 | erlotinib | 0.4662703 | 0.9071261 | 0.46627 | NA | NA |
| BRAF | erlotinib | 0.4662981 | 0.9071261 | 0.46630 | NA | NA |
| PTCH1 | sunitinib | 0.4664159 | 0.9071261 | 0.46642 | NA | NA |
| MAP2K2 | docetaxel | 0.4671915 | 0.9080785 | 0.46719 | NA | NA |
| SETD2 | pazopanib | 0.4675792 | 0.9082761 | 0.46758 | NA | NA |
| ABL1 | imatinib | 0.4679914 | 0.9085212 | 0.46799 | NA | NA |
| TP53 | dasatinib | 0.4684244 | 0.9085467 | 0.46842 | NA | NA |
| BRCA2 | ponatinib | 0.4687534 | 0.9085467 | 0.46875 | NA | NA |
| PDGFRB | imatinib | 0.4699331 | 0.9085467 | 0.46993 | NA | NA |
| SMC1A | rucaparib | 0.4701617 | 0.9085467 | 0.47016 | NA | NA |
| PRPF40B | rucaparib | 0.4712034 | 0.9085467 | 0.47120 | NA | NA |
| CREBBP | ruxolitinib | 0.4719661 | 0.9085467 | 0.47197 | NA | NA |
| SMC3 | sunitinib | 0.4719892 | 0.9085467 | 0.47199 | NA | NA |
| IDH1 | gefitinib | 0.4721833 | 0.9085467 | 0.47218 | NA | NA |
| PTCH1 | dasatinib | 0.4723552 | 0.9085467 | 0.47236 | NA | NA |
| ERBB3 | palbociclib | 0.4724268 | 0.9085467 | 0.47243 | NA | NA |
| JAK3 | bosutinib monohydrate | 0.4728655 | 0.9085467 | 0.47287 | NA | NA |
| CDKN2A | imatinib | 0.4734754 | 0.9085467 | 0.47348 | NA | NA |
| SMC1A | afatinib | 0.4735125 | 0.9085467 | 0.47351 | NA | NA |
| MGMT | trametinib | 0.4735520 | 0.9085467 | 0.47355 | NA | NA |
| SMO | crizotinib | 0.4736088 | 0.9085467 | 0.47361 | NA | NA |
| GATA2 | alectinib | 0.4737183 | 0.9085467 | 0.47372 | NA | NA |
| CDK6 | alectinib | 0.4739041 | 0.9085467 | 0.47390 | NA | NA |
| CD79B | docetaxel | 0.4739139 | 0.9085467 | 0.47391 | NA | NA |
| TSC2 | vismodegib | 0.4749053 | 0.9085467 | 0.47491 | NA | NA |
| MPL | sunitinib | 0.4753748 | 0.9085467 | 0.47537 | NA | NA |
| SETD2 | trametinib | 0.4755931 | 0.9085467 | 0.47559 | NA | NA |
| PTCH1 | trametinib | 0.4756384 | 0.9085467 | 0.47564 | NA | NA |
| PDGFRB | ruxolitinib | 0.4765472 | 0.9085467 | 0.47655 | NA | NA |
| SF3B1 | palbociclib | 0.4773083 | 0.9085467 | 0.47731 | NA | NA |
| MYD88 | tretinoin | 0.4774785 | 0.9085467 | 0.47748 | NA | NA |
| CDC73 | belinostat | 0.4780499 | 0.9085467 | 0.47805 | NA | NA |
| PDGFRA | vismodegib | 0.4781819 | 0.9085467 | 0.47818 | NA | NA |
| FANCL | ruxolitinib | 0.4784767 | 0.9085467 | 0.47848 | NA | NA |
| BRCA1 | ruxolitinib | 0.4788739 | 0.9085467 | 0.47887 | NA | NA |
| BCOR | bosutinib monohydrate | 0.4792497 | 0.9085467 | 0.47925 | NA | NA |
| PRPF40B | pazopanib | 0.4793312 | 0.9085467 | 0.47933 | NA | NA |
| CTNNB1 | palbociclib | 0.4793518 | 0.9085467 | 0.47935 | NA | NA |
| CRLF2 | crizotinib | 0.4795458 | 0.9085467 | 0.47955 | NA | NA |
| G6PD | belinostat | 0.4798818 | 0.9085467 | 0.47988 | NA | NA |
| GATA2 | lapatinib | 0.4800955 | 0.9085467 | 0.48010 | NA | NA |
| CREBBP | afatinib | 0.4804225 | 0.9085467 | 0.48042 | NA | NA |
| PDCD1 | sunitinib | 0.4810096 | 0.9085467 | 0.48101 | NA | NA |
| CALR | sunitinib | 0.4811019 | 0.9085467 | 0.48110 | NA | NA |
| NT5C2 | rucaparib | 0.4816750 | 0.9085467 | 0.48168 | NA | NA |
| NPM1 | ruxolitinib | 0.4817234 | 0.9085467 | 0.48172 | NA | NA |
| PDGFB | ponatinib | 0.4821695 | 0.9085467 | 0.48217 | NA | NA |
| AR | vismodegib | 0.4823074 | 0.9085467 | 0.48231 | NA | NA |
| ETV6 | rucaparib | 0.4827390 | 0.9085467 | 0.48274 | NA | NA |
| JAK3 | midostaurin | 0.4827637 | 0.9085467 | 0.48276 | NA | NA |
| PRPF40B | afatinib | 0.4830174 | 0.9085467 | 0.48302 | NA | NA |
| PRPF40B | gefitinib | 0.4831030 | 0.9085467 | 0.48310 | NA | NA |
| HRAS | vismodegib | 0.4831149 | 0.9085467 | 0.48311 | NA | NA |
| G6PD | pazopanib | 0.4835225 | 0.9085467 | 0.48352 | NA | NA |
| BCOR | dasatinib | 0.4835917 | 0.9085467 | 0.48359 | NA | NA |
| GNAS | dabrafenib | 0.4837630 | 0.9085467 | 0.48376 | NA | NA |
| NOTCH1 | erlotinib | 0.4838940 | 0.9085467 | 0.48389 | NA | NA |
| ZRSR2 | pazopanib | 0.4840326 | 0.9085467 | 0.48403 | NA | NA |
| ERBB2 | sunitinib | 0.4842706 | 0.9085467 | 0.48427 | NA | NA |
| BCOR | nilotinib | 0.4843638 | 0.9085467 | 0.48436 | NA | NA |
| WHSC1 | palbociclib | 0.4845512 | 0.9085467 | 0.48455 | NA | NA |
| CYP19A1 | docetaxel | 0.4847190 | 0.9085467 | 0.48472 | NA | NA |
| ASXL1 | pazopanib | 0.4847323 | 0.9085467 | 0.48473 | NA | NA |
| CTCF | afatinib | 0.4847708 | 0.9085467 | 0.48477 | NA | NA |
| EGF | pazopanib | 0.4848824 | 0.9085467 | 0.48488 | NA | NA |
| AKT3 | afatinib | 0.4858445 | 0.9093988 | 0.48584 | NA | NA |
| CDC73 | gefitinib | 0.4859099 | 0.9093988 | 0.48591 | NA | NA |
| WT1 | belinostat | 0.4865711 | 0.9101000 | 0.48657 | NA | NA |
| GNAQ | midostaurin | 0.4871146 | 0.9103158 | 0.48711 | NA | NA |
| PDGFRB | afatinib | 0.4872986 | 0.9103158 | 0.48730 | NA | NA |
| CSF3R | erlotinib | 0.4879427 | 0.9103158 | 0.48794 | NA | NA |
| STAT3 | gefitinib | 0.4879455 | 0.9103158 | 0.48795 | NA | NA |
| PHF6 | imatinib | 0.4884193 | 0.9103158 | 0.48842 | NA | NA |
| KRAS | erlotinib | 0.4886809 | 0.9103158 | 0.48868 | NA | NA |
| CBLB | vismodegib | 0.4886928 | 0.9103158 | 0.48869 | NA | NA |
| GNAS | crizotinib | 0.4890065 | 0.9103662 | 0.48901 | NA | NA |
| KMT2A | rucaparib | 0.4911204 | 0.9124230 | 0.49112 | NA | NA |
| TSC2 | erlotinib | 0.4915604 | 0.9124230 | 0.49156 | NA | NA |
| UGT1A1 | nilotinib | 0.4918297 | 0.9124230 | 0.49183 | NA | NA |
| GATA2 | tretinoin | 0.4920281 | 0.9124230 | 0.49203 | NA | NA |
| KMT2A | vismodegib | 0.4929627 | 0.9124230 | 0.49296 | NA | NA |
| CBLB | cabozantinib | 0.4931138 | 0.9124230 | 0.49311 | NA | NA |
| RIT1 | docetaxel | 0.4934091 | 0.9124230 | 0.49341 | NA | NA |
| AR | erlotinib | 0.4934194 | 0.9124230 | 0.49342 | NA | NA |
| EZH2 | pazopanib | 0.4934659 | 0.9124230 | 0.49347 | NA | NA |
| IDH1 | vismodegib | 0.4935289 | 0.9124230 | 0.49353 | NA | NA |
| CYP19A1 | lapatinib | 0.4937490 | 0.9124230 | 0.49375 | NA | NA |
| JAK1 | dabrafenib | 0.4940334 | 0.9124230 | 0.49403 | NA | NA |
| SSX1 | docetaxel | 0.4946266 | 0.9124230 | 0.49463 | NA | NA |
| KMT2A | docetaxel | 0.4952628 | 0.9124230 | 0.49526 | NA | NA |
| IKZF1 | ponatinib | 0.4960463 | 0.9124230 | 0.49605 | NA | NA |
| PDGFB | dabrafenib | 0.4964153 | 0.9124230 | 0.49642 | NA | NA |
| PDCD1 | imatinib | 0.4965076 | 0.9124230 | 0.49651 | NA | NA |
| KMT2A | bosutinib monohydrate | 0.4965364 | 0.9124230 | 0.49654 | NA | NA |
| RET | tretinoin | 0.4969056 | 0.9124230 | 0.49691 | NA | NA |
| JAK3 | palbociclib | 0.4969978 | 0.9124230 | 0.49700 | NA | NA |
| AR | nilotinib | 0.4970145 | 0.9124230 | 0.49701 | NA | NA |
| ALK | midostaurin | 0.4971993 | 0.9124230 | 0.49720 | NA | NA |
| U2AF1 | afatinib | 0.4972408 | 0.9124230 | 0.49724 | NA | NA |
| CSF3R | docetaxel | 0.4974614 | 0.9124230 | 0.49746 | NA | NA |
| PHF6 | erlotinib | 0.4975229 | 0.9124230 | 0.49752 | NA | NA |
| CXCR4 | rucaparib | 0.4978429 | 0.9124230 | 0.49784 | NA | NA |
| MAP2K1 | erlotinib | 0.4978681 | 0.9124230 | 0.49787 | NA | NA |
| MYD88 | cabozantinib | 0.4985291 | 0.9124284 | 0.49853 | NA | NA |
| PDGFRA | sunitinib | 0.4989956 | 0.9124284 | 0.49900 | NA | NA |
| RET | cabozantinib | 0.4991041 | 0.9124284 | 0.49910 | NA | NA |
| DDIT3 | dabrafenib | 0.4991662 | 0.9124284 | 0.49917 | NA | NA |
| EGFR | nilotinib | 0.4993412 | 0.9124284 | 0.49934 | NA | NA |
| PTEN | trametinib | 0.4995948 | 0.9124284 | 0.49959 | NA | NA |
| PIK3CA | palbociclib | 0.5003636 | 0.9133073 | 0.50036 | NA | NA |
| CDK6 | dasatinib | 0.5013750 | 0.9141140 | 0.50137 | NA | NA |
| WHSC1 | sunitinib | 0.5013812 | 0.9141140 | 0.50138 | NA | NA |
| FBXW7 | pazopanib | 0.5019388 | 0.9142288 | 0.50194 | NA | NA |
| STAT3 | belinostat | 0.5022511 | 0.9142288 | 0.50225 | NA | NA |
| NT5C2 | temozolomide | 0.5024237 | 0.9142288 | 0.50242 | NA | NA |
| ERBB3 | lapatinib | 0.5028840 | 0.9142288 | 0.50288 | NA | NA |
| FANCL | cabozantinib | 0.5034590 | 0.9142288 | 0.50346 | NA | NA |
| RET | crizotinib | 0.5041789 | 0.9142288 | 0.50418 | NA | NA |
| KMT2A | ruxolitinib | 0.5043906 | 0.9142288 | 0.50439 | NA | NA |
| G6PD | imatinib | 0.5046668 | 0.9142288 | 0.50467 | NA | NA |
| CEBPA | cabozantinib | 0.5051263 | 0.9142288 | 0.50513 | NA | NA |
| NOTCH2 | bosutinib monohydrate | 0.5054644 | 0.9142288 | 0.50546 | NA | NA |
| PHF6 | sunitinib | 0.5059450 | 0.9142288 | 0.50594 | NA | NA |
| DDIT3 | midostaurin | 0.5062536 | 0.9142288 | 0.50625 | NA | NA |
| RAD21 | gefitinib | 0.5067814 | 0.9142288 | 0.50678 | NA | NA |
| NOTCH2 | midostaurin | 0.5068663 | 0.9142288 | 0.50687 | NA | NA |
| GATA1 | lapatinib | 0.5069297 | 0.9142288 | 0.50693 | NA | NA |
| ATM | dasatinib | 0.5070758 | 0.9142288 | 0.50708 | NA | NA |
| DDIT3 | cabozantinib | 0.5071215 | 0.9142288 | 0.50712 | NA | NA |
| CYP19A1 | afatinib | 0.5081199 | 0.9142288 | 0.50812 | NA | NA |
| SSX1 | midostaurin | 0.5081623 | 0.9142288 | 0.50816 | NA | NA |
| PAX5 | gefitinib | 0.5085301 | 0.9142288 | 0.50853 | NA | NA |
| DPYD | midostaurin | 0.5086465 | 0.9142288 | 0.50865 | NA | NA |
| ERBB3 | pazopanib | 0.5092517 | 0.9142288 | 0.50925 | NA | NA |
| CTCF | tretinoin | 0.5098762 | 0.9142288 | 0.50988 | NA | NA |
| TET2 | imatinib | 0.5098787 | 0.9142288 | 0.50988 | NA | NA |
| CDK4 | pazopanib | 0.5102304 | 0.9142288 | 0.51023 | NA | NA |
| HRAS | ponatinib | 0.5102704 | 0.9142288 | 0.51027 | NA | NA |
| MYCN | temozolomide | 0.5105673 | 0.9142288 | 0.51057 | NA | NA |
| PDGFRB | sunitinib | 0.5106193 | 0.9142288 | 0.51062 | NA | NA |
| STAG2 | erlotinib | 0.5108704 | 0.9142288 | 0.51087 | NA | NA |
| BRAF | gefitinib | 0.5109860 | 0.9142288 | 0.51099 | NA | NA |
| ASXL1 | docetaxel | 0.5112416 | 0.9142288 | 0.51124 | NA | NA |
| GATA1 | trametinib | 0.5114237 | 0.9142288 | 0.51142 | NA | NA |
| PML | vismodegib | 0.5118312 | 0.9142288 | 0.51183 | NA | NA |
| FANCL | trametinib | 0.5123217 | 0.9142288 | 0.51232 | NA | NA |
| CBL | ruxolitinib | 0.5128995 | 0.9142288 | 0.51290 | NA | NA |
| SETD2 | dasatinib | 0.5131984 | 0.9142288 | 0.51320 | NA | NA |
| KIT | palbociclib | 0.5134101 | 0.9142288 | 0.51341 | NA | NA |
| CDK6 | nilotinib | 0.5134963 | 0.9142288 | 0.51350 | NA | NA |
| ESR1 | dabrafenib | 0.5138002 | 0.9142288 | 0.51380 | NA | NA |
| PIK3CA | tretinoin | 0.5140711 | 0.9142288 | 0.51407 | NA | NA |
| EGF | temozolomide | 0.5143110 | 0.9142288 | 0.51431 | NA | NA |
| PDGFRB | temozolomide | 0.5143244 | 0.9142288 | 0.51432 | NA | NA |
| SF1 | sunitinib | 0.5144054 | 0.9142288 | 0.51441 | NA | NA |
| EML4 | palbociclib | 0.5149978 | 0.9142288 | 0.51500 | NA | NA |
| FLT3 | dabrafenib | 0.5153597 | 0.9142288 | 0.51536 | NA | NA |
| JAK3 | sunitinib | 0.5153903 | 0.9142288 | 0.51539 | NA | NA |
| CDKN2A | belinostat | 0.5154714 | 0.9142288 | 0.51547 | NA | NA |
| SMC3 | erlotinib | 0.5156776 | 0.9142288 | 0.51568 | NA | NA |
| MYD88 | dasatinib | 0.5156798 | 0.9142288 | 0.51568 | NA | NA |
| SMC1A | pazopanib | 0.5163177 | 0.9142288 | 0.51632 | NA | NA |
| DPYD | ruxolitinib | 0.5165164 | 0.9142288 | 0.51652 | NA | NA |
| CYP19A1 | sunitinib | 0.5166344 | 0.9142288 | 0.51663 | NA | NA |
| EZH2 | dasatinib | 0.5167556 | 0.9142288 | 0.51676 | NA | NA |
| MPL | belinostat | 0.5173049 | 0.9142288 | 0.51730 | NA | NA |
| IL7R | nilotinib | 0.5173148 | 0.9142288 | 0.51731 | NA | NA |
| DPYD | docetaxel | 0.5183010 | 0.9142288 | 0.51830 | NA | NA |
| CD79B | palbociclib | 0.5185060 | 0.9142288 | 0.51851 | NA | NA |
| DDIT3 | rucaparib | 0.5186394 | 0.9142288 | 0.51864 | NA | NA |
| FGFR1 | crizotinib | 0.5187132 | 0.9142288 | 0.51871 | NA | NA |
| GNA11 | ruxolitinib | 0.5187155 | 0.9142288 | 0.51872 | NA | NA |
| PAX8 | dabrafenib | 0.5195687 | 0.9145772 | 0.51957 | NA | NA |
| MET | docetaxel | 0.5196512 | 0.9145772 | 0.51965 | NA | NA |
| PTPN11 | temozolomide | 0.5198840 | 0.9145772 | 0.51988 | NA | NA |
| DPYD | imatinib | 0.5204070 | 0.9145772 | 0.52041 | NA | NA |
| EGFR | imatinib | 0.5206143 | 0.9145772 | 0.52061 | NA | NA |
| DPYD | gefitinib | 0.5210093 | 0.9145772 | 0.52101 | NA | NA |
| GNAQ | pazopanib | 0.5212039 | 0.9145772 | 0.52120 | NA | NA |
| PRPF8 | cabozantinib | 0.5214349 | 0.9145772 | 0.52143 | NA | NA |
| DNMT3A | palbociclib | 0.5222786 | 0.9145772 | 0.52228 | NA | NA |
| CBLB | midostaurin | 0.5224343 | 0.9145772 | 0.52243 | NA | NA |
| FANCL | lapatinib | 0.5224774 | 0.9145772 | 0.52248 | NA | NA |
| DPYD | alectinib | 0.5225472 | 0.9145772 | 0.52255 | NA | NA |
| NPM1 | gefitinib | 0.5227495 | 0.9145772 | 0.52275 | NA | NA |
| CDK4 | trametinib | 0.5235152 | 0.9145772 | 0.52352 | NA | NA |
| CREBBP | tretinoin | 0.5236971 | 0.9145772 | 0.52370 | NA | NA |
| SF1 | crizotinib | 0.5238314 | 0.9145772 | 0.52383 | NA | NA |
| RPL10 | dabrafenib | 0.5241142 | 0.9145772 | 0.52411 | NA | NA |
| KMT2A | trametinib | 0.5242068 | 0.9145772 | 0.52421 | NA | NA |
| ASXL1 | palbociclib | 0.5246346 | 0.9145772 | 0.52463 | NA | NA |
| FGFR3 | rucaparib | 0.5246724 | 0.9145772 | 0.52467 | NA | NA |
| CTCF | vismodegib | 0.5249865 | 0.9146226 | 0.52499 | NA | NA |
| MDM2 | gefitinib | 0.5257801 | 0.9150605 | 0.52578 | NA | NA |
| AKT3 | crizotinib | 0.5260488 | 0.9150605 | 0.52605 | NA | NA |
| CSF3R | cabozantinib | 0.5261751 | 0.9150605 | 0.52618 | NA | NA |
| NRAS | midostaurin | 0.5263903 | 0.9150605 | 0.52639 | NA | NA |
| GATA2 | belinostat | 0.5271314 | 0.9158476 | 0.52713 | NA | NA |
| JAK3 | lapatinib | 0.5279853 | 0.9163898 | 0.52799 | NA | NA |
| PDGFB | trametinib | 0.5280206 | 0.9163898 | 0.52802 | NA | NA |
| NT5C2 | vismodegib | 0.5285543 | 0.9168151 | 0.52855 | NA | NA |
| SMC3 | bosutinib monohydrate | 0.5290075 | 0.9169691 | 0.52901 | NA | NA |
| BRAF | sunitinib | 0.5308225 | 0.9169691 | 0.53082 | NA | NA |
| MYD88 | midostaurin | 0.5310291 | 0.9169691 | 0.53103 | NA | NA |
| WT1 | pazopanib | 0.5310459 | 0.9169691 | 0.53105 | NA | NA |
| RUNX1 | palbociclib | 0.5310874 | 0.9169691 | 0.53109 | NA | NA |
| TET2 | afatinib | 0.5315227 | 0.9169691 | 0.53152 | NA | NA |
| ABL1 | crizotinib | 0.5320626 | 0.9169691 | 0.53206 | NA | NA |
| CBL | imatinib | 0.5322515 | 0.9169691 | 0.53225 | NA | NA |
| CXCR4 | temozolomide | 0.5324701 | 0.9169691 | 0.53247 | NA | NA |
| DNMT3A | midostaurin | 0.5328652 | 0.9169691 | 0.53287 | NA | NA |
| PHF6 | ponatinib | 0.5333653 | 0.9169691 | 0.53337 | NA | NA |
| CTCF | bosutinib monohydrate | 0.5335475 | 0.9169691 | 0.53355 | NA | NA |
| PHF6 | alectinib | 0.5336040 | 0.9169691 | 0.53360 | NA | NA |
| SMO | midostaurin | 0.5343564 | 0.9169691 | 0.53436 | NA | NA |
| JAK3 | cabozantinib | 0.5344359 | 0.9169691 | 0.53444 | NA | NA |
| G6PD | erlotinib | 0.5348254 | 0.9169691 | 0.53483 | NA | NA |
| AR | alectinib | 0.5352746 | 0.9169691 | 0.53527 | NA | NA |
| CBL | docetaxel | 0.5357729 | 0.9169691 | 0.53577 | NA | NA |
| CDK4 | dasatinib | 0.5363244 | 0.9169691 | 0.53632 | NA | NA |
| JAK3 | erlotinib | 0.5363347 | 0.9169691 | 0.53633 | NA | NA |
| ERBB3 | nilotinib | 0.5371710 | 0.9169691 | 0.53717 | NA | NA |
| ETV6 | ruxolitinib | 0.5373343 | 0.9169691 | 0.53733 | NA | NA |
| SSX1 | ponatinib | 0.5376169 | 0.9169691 | 0.53762 | NA | NA |
| CXCR4 | palbociclib | 0.5381348 | 0.9169691 | 0.53813 | NA | NA |
| RAD21 | ponatinib | 0.5382645 | 0.9169691 | 0.53826 | NA | NA |
| SF1 | gefitinib | 0.5385821 | 0.9169691 | 0.53858 | NA | NA |
| MAP2K2 | nilotinib | 0.5386936 | 0.9169691 | 0.53869 | NA | NA |
| ETV6 | alectinib | 0.5387069 | 0.9169691 | 0.53871 | NA | NA |
| RUNX1 | dabrafenib | 0.5389208 | 0.9169691 | 0.53892 | NA | NA |
| MYCN | trametinib | 0.5389272 | 0.9169691 | 0.53893 | NA | NA |
| TSC2 | imatinib | 0.5394738 | 0.9169691 | 0.53947 | NA | NA |
| FGFR2 | nilotinib | 0.5398280 | 0.9169691 | 0.53983 | NA | NA |
| BCORL1 | crizotinib | 0.5399529 | 0.9169691 | 0.53995 | NA | NA |
| GNA11 | afatinib | 0.5399949 | 0.9169691 | 0.53999 | NA | NA |
| CEBPA | rucaparib | 0.5399967 | 0.9169691 | 0.54000 | NA | NA |
| ABL1 | midostaurin | 0.5402282 | 0.9169691 | 0.54023 | NA | NA |
| MPL | alectinib | 0.5402344 | 0.9169691 | 0.54023 | NA | NA |
| STAT3 | midostaurin | 0.5403698 | 0.9169691 | 0.54037 | NA | NA |
| CTLA4 | gefitinib | 0.5404583 | 0.9169691 | 0.54046 | NA | NA |
| WT1 | vismodegib | 0.5404655 | 0.9169691 | 0.54047 | NA | NA |
| PTCH1 | dabrafenib | 0.5410696 | 0.9169691 | 0.54107 | NA | NA |
| ETV6 | ponatinib | 0.5414576 | 0.9169691 | 0.54146 | NA | NA |
| BRCA2 | temozolomide | 0.5416844 | 0.9169691 | 0.54168 | NA | NA |
| CXCR4 | midostaurin | 0.5422466 | 0.9169691 | 0.54225 | NA | NA |
| PIGA | nilotinib | 0.5423423 | 0.9169691 | 0.54234 | NA | NA |
| SMO | ponatinib | 0.5427786 | 0.9169691 | 0.54278 | NA | NA |
| WT1 | temozolomide | 0.5429937 | 0.9169691 | 0.54299 | NA | NA |
| PIGA | palbociclib | 0.5433316 | 0.9169691 | 0.54333 | NA | NA |
| TSC2 | midostaurin | 0.5433441 | 0.9169691 | 0.54334 | NA | NA |
| TET2 | docetaxel | 0.5434908 | 0.9169691 | 0.54349 | NA | NA |
| FBXW7 | rucaparib | 0.5434920 | 0.9169691 | 0.54349 | NA | NA |
| JAK3 | temozolomide | 0.5436890 | 0.9169691 | 0.54369 | NA | NA |
| SETBP1 | docetaxel | 0.5442333 | 0.9169691 | 0.54423 | NA | NA |
| CBL | midostaurin | 0.5442339 | 0.9169691 | 0.54423 | NA | NA |
| SF1 | temozolomide | 0.5448516 | 0.9175231 | 0.54485 | NA | NA |
| FLCN | midostaurin | 0.5460539 | 0.9190606 | 0.54605 | NA | NA |
| AKT1 | cabozantinib | 0.5467795 | 0.9196205 | 0.54678 | NA | NA |
| GNAS | lapatinib | 0.5469657 | 0.9196205 | 0.54697 | NA | NA |
| UGT1A1 | dabrafenib | 0.5474325 | 0.9199087 | 0.54743 | NA | NA |
| PDGFB | midostaurin | 0.5477164 | 0.9199087 | 0.54772 | NA | NA |
| WT1 | docetaxel | 0.5485785 | 0.9204284 | 0.54858 | NA | NA |
| BTK | rucaparib | 0.5488597 | 0.9204284 | 0.54886 | NA | NA |
| GNB1 | gefitinib | 0.5488952 | 0.9204284 | 0.54890 | NA | NA |
| UGT1A1 | temozolomide | 0.5500430 | 0.9206369 | 0.55004 | NA | NA |
| MGMT | crizotinib | 0.5501355 | 0.9206369 | 0.55014 | NA | NA |
| CDK6 | tretinoin | 0.5504161 | 0.9206369 | 0.55042 | NA | NA |
| RET | bosutinib monohydrate | 0.5509591 | 0.9206369 | 0.55096 | NA | NA |
| ROS1 | gefitinib | 0.5511895 | 0.9206369 | 0.55119 | NA | NA |
| GNAS | pazopanib | 0.5517444 | 0.9206369 | 0.55174 | NA | NA |
| PAX5 | alectinib | 0.5518586 | 0.9206369 | 0.55186 | NA | NA |
| CD79B | belinostat | 0.5522460 | 0.9206369 | 0.55225 | NA | NA |
| KIT | midostaurin | 0.5523909 | 0.9206369 | 0.55239 | NA | NA |
| CYP19A1 | pazopanib | 0.5523979 | 0.9206369 | 0.55240 | NA | NA |
| CD274 | afatinib | 0.5528302 | 0.9206369 | 0.55283 | NA | NA |
| IDH1 | ruxolitinib | 0.5528888 | 0.9206369 | 0.55289 | NA | NA |
| ERBB3 | alectinib | 0.5530430 | 0.9206369 | 0.55304 | NA | NA |
| STAT3 | cabozantinib | 0.5530778 | 0.9206369 | 0.55308 | NA | NA |
| MGMT | ponatinib | 0.5540759 | 0.9207127 | 0.55408 | NA | NA |
| AKT1 | belinostat | 0.5547454 | 0.9207127 | 0.55475 | NA | NA |
| ATM | alectinib | 0.5548611 | 0.9207127 | 0.55486 | NA | NA |
| CYP19A1 | tretinoin | 0.5549899 | 0.9207127 | 0.55499 | NA | NA |
| MYCN | gefitinib | 0.5550598 | 0.9207127 | 0.55506 | NA | NA |
| ZRSR2 | belinostat | 0.5551241 | 0.9207127 | 0.55512 | NA | NA |
| MPL | palbociclib | 0.5554405 | 0.9207127 | 0.55544 | NA | NA |
| AKT2 | midostaurin | 0.5554426 | 0.9207127 | 0.55544 | NA | NA |
| RUNX1 | belinostat | 0.5560288 | 0.9212037 | 0.55603 | NA | NA |
| GATA3 | cabozantinib | 0.5564051 | 0.9213465 | 0.55641 | NA | NA |
| TSC2 | dasatinib | 0.5568736 | 0.9216417 | 0.55687 | NA | NA |
| MYD88 | erlotinib | 0.5580136 | 0.9226946 | 0.55801 | NA | NA |
| ALK | pazopanib | 0.5581192 | 0.9226946 | 0.55812 | NA | NA |
| GATA1 | vismodegib | 0.5583929 | 0.9226946 | 0.55839 | NA | NA |
| CD79B | gefitinib | 0.5587538 | 0.9226946 | 0.55875 | NA | NA |
| PAX8 | belinostat | 0.5590195 | 0.9226946 | 0.55902 | NA | NA |
| PTPN11 | afatinib | 0.5596334 | 0.9226946 | 0.55963 | NA | NA |
| RET | ruxolitinib | 0.5597886 | 0.9226946 | 0.55979 | NA | NA |
| IKZF1 | bosutinib monohydrate | 0.5599796 | 0.9226946 | 0.55998 | NA | NA |
| CEBPA | gefitinib | 0.5601244 | 0.9226946 | 0.56012 | NA | NA |
| MAP2K2 | alectinib | 0.5608883 | 0.9234739 | 0.56089 | NA | NA |
| ERBB3 | afatinib | 0.5614904 | 0.9239863 | 0.56149 | NA | NA |
| JAK2 | crizotinib | 0.5623793 | 0.9240874 | 0.56238 | NA | NA |
| PML | pazopanib | 0.5629739 | 0.9240874 | 0.56297 | NA | NA |
| BCOR | erlotinib | 0.5633547 | 0.9240874 | 0.56335 | NA | NA |
| TSC1 | erlotinib | 0.5633547 | 0.9240874 | 0.56335 | NA | NA |
| EGF | erlotinib | 0.5636517 | 0.9240874 | 0.56365 | NA | NA |
| PIGA | dasatinib | 0.5637000 | 0.9240874 | 0.56370 | NA | NA |
| ESR1 | sunitinib | 0.5643768 | 0.9240874 | 0.56438 | NA | NA |
| G6PD | rucaparib | 0.5646292 | 0.9240874 | 0.56463 | NA | NA |
| MDM2 | ruxolitinib | 0.5647650 | 0.9240874 | 0.56476 | NA | NA |
| PAX8 | palbociclib | 0.5648846 | 0.9240874 | 0.56488 | NA | NA |
| RET | gefitinib | 0.5658382 | 0.9240874 | 0.56584 | NA | NA |
| FLT3 | sunitinib | 0.5660424 | 0.9240874 | 0.56604 | NA | NA |
| PDGFB | sunitinib | 0.5660424 | 0.9240874 | 0.56604 | NA | NA |
| CBLB | dabrafenib | 0.5660789 | 0.9240874 | 0.56608 | NA | NA |
| NCOA2 | midostaurin | 0.5663758 | 0.9240874 | 0.56638 | NA | NA |
| EGFR | temozolomide | 0.5669345 | 0.9240874 | 0.56693 | NA | NA |
| CD79B | bosutinib monohydrate | 0.5670616 | 0.9240874 | 0.56706 | NA | NA |
| JAK2 | palbociclib | 0.5675682 | 0.9240874 | 0.56757 | NA | NA |
| TET2 | crizotinib | 0.5676235 | 0.9240874 | 0.56762 | NA | NA |
| BTK | ruxolitinib | 0.5677799 | 0.9240874 | 0.56778 | NA | NA |
| FLT3 | lapatinib | 0.5679419 | 0.9240874 | 0.56794 | NA | NA |
| CYP19A1 | gefitinib | 0.5683932 | 0.9240874 | 0.56839 | NA | NA |
| FGFR3 | palbociclib | 0.5685115 | 0.9240874 | 0.56851 | NA | NA |
| PAX8 | crizotinib | 0.5685501 | 0.9240874 | 0.56855 | NA | NA |
| AR | imatinib | 0.5689905 | 0.9240874 | 0.56899 | NA | NA |
| CSF3R | vismodegib | 0.5693374 | 0.9240874 | 0.56934 | NA | NA |
| AKT3 | imatinib | 0.5699859 | 0.9240874 | 0.56999 | NA | NA |
| CDK6 | imatinib | 0.5699859 | 0.9240874 | 0.56999 | NA | NA |
| CD274 | trametinib | 0.5701244 | 0.9240874 | 0.57012 | NA | NA |
| JAK2 | erlotinib | 0.5702807 | 0.9240874 | 0.57028 | NA | NA |
| SMC3 | afatinib | 0.5706429 | 0.9242029 | 0.57064 | NA | NA |
| TSC2 | cabozantinib | 0.5710996 | 0.9244710 | 0.57110 | NA | NA |
| CDC73 | ruxolitinib | 0.5718819 | 0.9249377 | 0.57188 | NA | NA |
| SF1 | tretinoin | 0.5723561 | 0.9249377 | 0.57236 | NA | NA |
| BTK | vismodegib | 0.5724794 | 0.9249377 | 0.57248 | NA | NA |
| TSC1 | docetaxel | 0.5725527 | 0.9249377 | 0.57255 | NA | NA |
| IL7R | crizotinib | 0.5731295 | 0.9253987 | 0.57313 | NA | NA |
| FGFR1 | imatinib | 0.5744946 | 0.9267696 | 0.57449 | NA | NA |
| WT1 | crizotinib | 0.5747532 | 0.9267696 | 0.57475 | NA | NA |
| NRAS | sunitinib | 0.5749041 | 0.9267696 | 0.57490 | NA | NA |
| STAT3 | imatinib | 0.5754057 | 0.9267696 | 0.57541 | NA | NA |
| U2AF1 | alectinib | 0.5756944 | 0.9267696 | 0.57569 | NA | NA |
| CTNNB1 | ponatinib | 0.5759382 | 0.9267696 | 0.57594 | NA | NA |
| JAK3 | ponatinib | 0.5765409 | 0.9267696 | 0.57654 | NA | NA |
| PRPF8 | vismodegib | 0.5766264 | 0.9267696 | 0.57663 | NA | NA |
| AKT3 | bosutinib monohydrate | 0.5766764 | 0.9267696 | 0.57668 | NA | NA |
| BRCA1 | rucaparib | 0.5768966 | 0.9267696 | 0.57690 | NA | NA |
| STAG2 | tretinoin | 0.5772249 | 0.9267965 | 0.57722 | NA | NA |
| CDC73 | palbociclib | 0.5776497 | 0.9267965 | 0.57765 | NA | NA |
| GNB1 | afatinib | 0.5781400 | 0.9267965 | 0.57814 | NA | NA |
| AKT3 | palbociclib | 0.5783610 | 0.9267965 | 0.57836 | NA | NA |
| CBLB | temozolomide | 0.5787407 | 0.9267965 | 0.57874 | NA | NA |
| MGMT | belinostat | 0.5789471 | 0.9267965 | 0.57895 | NA | NA |
| GNA11 | alectinib | 0.5790606 | 0.9267965 | 0.57906 | NA | NA |
| KMT2A | crizotinib | 0.5794379 | 0.9267965 | 0.57944 | NA | NA |
| ALK | cabozantinib | 0.5795396 | 0.9267965 | 0.57954 | NA | NA |
| ABL1 | sunitinib | 0.5802023 | 0.9273892 | 0.58020 | NA | NA |
| DNAJB1 | alectinib | 0.5806618 | 0.9273928 | 0.58066 | NA | NA |
| CDK6 | lapatinib | 0.5808070 | 0.9273928 | 0.58081 | NA | NA |
| ROS1 | midostaurin | 0.5814725 | 0.9273928 | 0.58147 | NA | NA |
| CD79B | afatinib | 0.5816393 | 0.9273928 | 0.58164 | NA | NA |
| ALK | rucaparib | 0.5819295 | 0.9273928 | 0.58193 | NA | NA |
| PRPF40B | dasatinib | 0.5822601 | 0.9273928 | 0.58226 | NA | NA |
| TSC2 | ruxolitinib | 0.5824296 | 0.9273928 | 0.58243 | NA | NA |
| CREBBP | dabrafenib | 0.5825405 | 0.9273928 | 0.58254 | NA | NA |
| PDGFRA | docetaxel | 0.5828922 | 0.9274878 | 0.58289 | NA | NA |
| PTCH1 | ruxolitinib | 0.5835921 | 0.9276687 | 0.58359 | NA | NA |
| RET | ponatinib | 0.5838741 | 0.9276687 | 0.58387 | NA | NA |
| RET | nilotinib | 0.5840052 | 0.9276687 | 0.58401 | NA | NA |
| VHL | dabrafenib | 0.5845704 | 0.9276687 | 0.58457 | NA | NA |
| GNA11 | belinostat | 0.5851873 | 0.9276687 | 0.58519 | NA | NA |
| TSC2 | rucaparib | 0.5851976 | 0.9276687 | 0.58520 | NA | NA |
| NPM1 | ponatinib | 0.5854791 | 0.9276687 | 0.58548 | NA | NA |
| GNA11 | tretinoin | 0.5858785 | 0.9276687 | 0.58588 | NA | NA |
| BRCA1 | afatinib | 0.5859699 | 0.9276687 | 0.58597 | NA | NA |
| EGFR | ponatinib | 0.5861711 | 0.9276687 | 0.58617 | NA | NA |
| STAT3 | afatinib | 0.5862188 | 0.9276687 | 0.58622 | NA | NA |
| CDK6 | palbociclib | 0.5875801 | 0.9283988 | 0.58758 | NA | NA |
| NOTCH2 | belinostat | 0.5876845 | 0.9283988 | 0.58768 | NA | NA |
| DNAJB1 | palbociclib | 0.5878256 | 0.9283988 | 0.58783 | NA | NA |
| TET2 | dasatinib | 0.5882617 | 0.9283988 | 0.58826 | NA | NA |
| PDGFRA | temozolomide | 0.5883211 | 0.9283988 | 0.58832 | NA | NA |
| CRLF2 | dasatinib | 0.5887259 | 0.9283988 | 0.58873 | NA | NA |
| PIK3CA | crizotinib | 0.5887265 | 0.9283988 | 0.58873 | NA | NA |
| CDK4 | midostaurin | 0.5892242 | 0.9286134 | 0.58922 | NA | NA |
| CDC73 | pazopanib | 0.5896955 | 0.9286134 | 0.58970 | NA | NA |
| FLCN | belinostat | 0.5905635 | 0.9286134 | 0.59056 | NA | NA |
| KMT2A | dasatinib | 0.5908858 | 0.9286134 | 0.59089 | NA | NA |
| CDK4 | cabozantinib | 0.5910559 | 0.9286134 | 0.59106 | NA | NA |
| PTEN | temozolomide | 0.5920742 | 0.9286134 | 0.59207 | NA | NA |
| GATA2 | crizotinib | 0.5930452 | 0.9286134 | 0.59305 | NA | NA |
| FGFR1 | dasatinib | 0.5933885 | 0.9286134 | 0.59339 | NA | NA |
| FBXW7 | vismodegib | 0.5934236 | 0.9286134 | 0.59342 | NA | NA |
| MAP2K1 | dabrafenib | 0.5935300 | 0.9286134 | 0.59353 | NA | NA |
| FGFR3 | sunitinib | 0.5938828 | 0.9286134 | 0.59388 | NA | NA |
| EGFR | tretinoin | 0.5940328 | 0.9286134 | 0.59403 | NA | NA |
| HRAS | pazopanib | 0.5941431 | 0.9286134 | 0.59414 | NA | NA |
| XPO1 | pazopanib | 0.5942691 | 0.9286134 | 0.59427 | NA | NA |
| STAT3 | rucaparib | 0.5946002 | 0.9286134 | 0.59460 | NA | NA |
| DNAJB1 | afatinib | 0.5947756 | 0.9286134 | 0.59478 | NA | NA |
| MYCN | midostaurin | 0.5948521 | 0.9286134 | 0.59485 | NA | NA |
| KIT | pazopanib | 0.5948891 | 0.9286134 | 0.59489 | NA | NA |
| PML | rucaparib | 0.5950165 | 0.9286134 | 0.59502 | NA | NA |
| EGFR | lapatinib | 0.5960871 | 0.9286134 | 0.59609 | NA | NA |
| NT5C2 | gefitinib | 0.5963461 | 0.9286134 | 0.59635 | NA | NA |
| WHSC1 | belinostat | 0.5965935 | 0.9286134 | 0.59659 | NA | NA |
| PTEN | gefitinib | 0.5969493 | 0.9286134 | 0.59695 | NA | NA |
| CDK6 | vismodegib | 0.5972260 | 0.9286134 | 0.59723 | NA | NA |
| ESR1 | ruxolitinib | 0.5973766 | 0.9286134 | 0.59738 | NA | NA |
| MGMT | nilotinib | 0.5978288 | 0.9286134 | 0.59783 | NA | NA |
| MYD88 | vismodegib | 0.5979041 | 0.9286134 | 0.59790 | NA | NA |
| PRPF40B | sunitinib | 0.5980324 | 0.9286134 | 0.59803 | NA | NA |
| CXCR4 | dasatinib | 0.5982362 | 0.9286134 | 0.59824 | NA | NA |
| SMC1A | nilotinib | 0.5984846 | 0.9286134 | 0.59848 | NA | NA |
| ABL1 | erlotinib | 0.5985108 | 0.9286134 | 0.59851 | NA | NA |
| NOTCH1 | palbociclib | 0.5985739 | 0.9286134 | 0.59857 | NA | NA |
| HRAS | ruxolitinib | 0.5989160 | 0.9286134 | 0.59892 | NA | NA |
| NOTCH1 | alectinib | 0.5992984 | 0.9286134 | 0.59930 | NA | NA |
| GATA3 | midostaurin | 0.5993247 | 0.9286134 | 0.59932 | NA | NA |
| IKZF1 | alectinib | 0.5993884 | 0.9286134 | 0.59939 | NA | NA |
| CEBPA | nilotinib | 0.6007708 | 0.9299466 | 0.60077 | NA | NA |
| IDH2 | sunitinib | 0.6010327 | 0.9299466 | 0.60103 | NA | NA |
| WT1 | imatinib | 0.6012342 | 0.9299466 | 0.60123 | NA | NA |
| VHL | sunitinib | 0.6024171 | 0.9299466 | 0.60242 | NA | NA |
| CBLB | belinostat | 0.6024277 | 0.9299466 | 0.60243 | NA | NA |
| CYP19A1 | cabozantinib | 0.6024929 | 0.9299466 | 0.60249 | NA | NA |
| BRAF | crizotinib | 0.6026642 | 0.9299466 | 0.60266 | NA | NA |
| AKT2 | bosutinib monohydrate | 0.6027318 | 0.9299466 | 0.60273 | NA | NA |
| CTNNB1 | sunitinib | 0.6030844 | 0.9299466 | 0.60308 | NA | NA |
| CBL | palbociclib | 0.6031882 | 0.9299466 | 0.60319 | NA | NA |
| SETD2 | sunitinib | 0.6036916 | 0.9299466 | 0.60369 | NA | NA |
| STAT3 | temozolomide | 0.6037625 | 0.9299466 | 0.60376 | NA | NA |
| SMC3 | nilotinib | 0.6046846 | 0.9301376 | 0.60468 | NA | NA |
| TPMT | trametinib | 0.6050220 | 0.9301376 | 0.60502 | NA | NA |
| SMO | rucaparib | 0.6056010 | 0.9301376 | 0.60560 | NA | NA |
| ROS1 | sunitinib | 0.6060667 | 0.9301376 | 0.60607 | NA | NA |
| ATM | trametinib | 0.6061888 | 0.9301376 | 0.60619 | NA | NA |
| GNA11 | trametinib | 0.6063817 | 0.9301376 | 0.60638 | NA | NA |
| XPO1 | palbociclib | 0.6065594 | 0.9301376 | 0.60656 | NA | NA |
| GATA2 | docetaxel | 0.6066753 | 0.9301376 | 0.60668 | NA | NA |
| GATA3 | ruxolitinib | 0.6067286 | 0.9301376 | 0.60673 | NA | NA |
| EED | trametinib | 0.6074766 | 0.9301376 | 0.60748 | NA | NA |
| CSF3R | sunitinib | 0.6077091 | 0.9301376 | 0.60771 | NA | NA |
| FGFR1 | rucaparib | 0.6079969 | 0.9301376 | 0.60800 | NA | NA |
| U2AF1 | tretinoin | 0.6080591 | 0.9301376 | 0.60806 | NA | NA |
| NRAS | dasatinib | 0.6085294 | 0.9301376 | 0.60853 | NA | NA |
| AKT3 | ruxolitinib | 0.6086854 | 0.9301376 | 0.60869 | NA | NA |
| SH2B3 | ruxolitinib | 0.6086854 | 0.9301376 | 0.60869 | NA | NA |
| EGF | alectinib | 0.6088652 | 0.9301376 | 0.60887 | NA | NA |
| DNAJB1 | tretinoin | 0.6098927 | 0.9305135 | 0.60989 | NA | NA |
| ERBB4 | vismodegib | 0.6099615 | 0.9305135 | 0.60996 | NA | NA |
| MDM2 | lapatinib | 0.6102843 | 0.9305135 | 0.61028 | NA | NA |
| CDK4 | temozolomide | 0.6106364 | 0.9305135 | 0.61064 | NA | NA |
| CDK4 | afatinib | 0.6107092 | 0.9305135 | 0.61071 | NA | NA |
| BCOR | sunitinib | 0.6110543 | 0.9305135 | 0.61105 | NA | NA |
| SETBP1 | bosutinib monohydrate | 0.6114437 | 0.9305135 | 0.61144 | NA | NA |
| BRCA2 | docetaxel | 0.6116514 | 0.9305135 | 0.61165 | NA | NA |
| SRSF2 | belinostat | 0.6119949 | 0.9305135 | 0.61199 | NA | NA |
| NT5C2 | midostaurin | 0.6123593 | 0.9305135 | 0.61236 | NA | NA |
| TSC1 | ponatinib | 0.6125905 | 0.9305135 | 0.61259 | NA | NA |
| CALR | crizotinib | 0.6126271 | 0.9305135 | 0.61263 | NA | NA |
| TP53 | lapatinib | 0.6134430 | 0.9312519 | 0.61344 | NA | NA |
| CSF3R | pazopanib | 0.6141144 | 0.9312519 | 0.61411 | NA | NA |
| ETV6 | crizotinib | 0.6144403 | 0.9312519 | 0.61444 | NA | NA |
| PRPF8 | belinostat | 0.6148581 | 0.9312519 | 0.61486 | NA | NA |
| FGFR2 | lapatinib | 0.6157059 | 0.9312519 | 0.61571 | NA | NA |
| GNAS | ruxolitinib | 0.6157098 | 0.9312519 | 0.61571 | NA | NA |
| MET | ponatinib | 0.6159349 | 0.9312519 | 0.61593 | NA | NA |
| GATA2 | gefitinib | 0.6160722 | 0.9312519 | 0.61607 | NA | NA |
| NOTCH1 | sunitinib | 0.6162376 | 0.9312519 | 0.61624 | NA | NA |
| GATA2 | vismodegib | 0.6168478 | 0.9312519 | 0.61685 | NA | NA |
| DDIT3 | gefitinib | 0.6170733 | 0.9312519 | 0.61707 | NA | NA |
| AKT2 | sunitinib | 0.6176121 | 0.9312519 | 0.61761 | NA | NA |
| VHL | pazopanib | 0.6176221 | 0.9312519 | 0.61762 | NA | NA |
| PML | ponatinib | 0.6178115 | 0.9312519 | 0.61781 | NA | NA |
| EML4 | docetaxel | 0.6185171 | 0.9312519 | 0.61852 | NA | NA |
| AKT1 | pazopanib | 0.6189835 | 0.9312519 | 0.61898 | NA | NA |
| CYP19A1 | crizotinib | 0.6190452 | 0.9312519 | 0.61905 | NA | NA |
| FLCN | trametinib | 0.6190484 | 0.9312519 | 0.61905 | NA | NA |
| CD79B | cabozantinib | 0.6190926 | 0.9312519 | 0.61909 | NA | NA |
| MYCN | cabozantinib | 0.6193520 | 0.9312519 | 0.61935 | NA | NA |
| JAK2 | afatinib | 0.6195384 | 0.9312519 | 0.61954 | NA | NA |
| SF1 | ponatinib | 0.6198294 | 0.9312519 | 0.61983 | NA | NA |
| PDCD1 | vismodegib | 0.6201762 | 0.9312519 | 0.62018 | NA | NA |
| ETV6 | gefitinib | 0.6204801 | 0.9312519 | 0.62048 | NA | NA |
| FGFR2 | alectinib | 0.6211625 | 0.9312519 | 0.62116 | NA | NA |
| G6PD | sunitinib | 0.6213525 | 0.9312519 | 0.62135 | NA | NA |
| PIGA | sunitinib | 0.6213525 | 0.9312519 | 0.62135 | NA | NA |
| FBXW7 | alectinib | 0.6219058 | 0.9312519 | 0.62191 | NA | NA |
| EED | cabozantinib | 0.6219404 | 0.9312519 | 0.62194 | NA | NA |
| NOTCH1 | ruxolitinib | 0.6220714 | 0.9312519 | 0.62207 | NA | NA |
| MGMT | bosutinib monohydrate | 0.6222029 | 0.9312519 | 0.62220 | NA | NA |
| DDIT3 | tretinoin | 0.6226906 | 0.9315427 | 0.62269 | NA | NA |
| CSF3R | ruxolitinib | 0.6235370 | 0.9319572 | 0.62354 | NA | NA |
| KRAS | gefitinib | 0.6235545 | 0.9319572 | 0.62355 | NA | NA |
| DNMT3A | tretinoin | 0.6240726 | 0.9319839 | 0.62407 | NA | NA |
| MPL | vismodegib | 0.6241592 | 0.9319839 | 0.62416 | NA | NA |
| ZRSR2 | ponatinib | 0.6253285 | 0.9332911 | 0.62533 | NA | NA |
| SMC3 | gefitinib | 0.6263365 | 0.9337683 | 0.62634 | NA | NA |
| PDGFB | belinostat | 0.6267736 | 0.9337683 | 0.62677 | NA | NA |
| SRSF2 | dabrafenib | 0.6268440 | 0.9337683 | 0.62684 | NA | NA |
| ZRSR2 | lapatinib | 0.6268747 | 0.9337683 | 0.62687 | NA | NA |
| MYD88 | pazopanib | 0.6271722 | 0.9337683 | 0.62717 | NA | NA |
| IDH1 | midostaurin | 0.6274123 | 0.9337683 | 0.62741 | NA | NA |
| ROS1 | afatinib | 0.6282804 | 0.9346222 | 0.62828 | NA | NA |
| PTEN | erlotinib | 0.6294097 | 0.9355064 | 0.62941 | NA | NA |
| SF3B1 | pazopanib | 0.6294639 | 0.9355064 | 0.62946 | NA | NA |
| EGF | tretinoin | 0.6298346 | 0.9356196 | 0.62983 | NA | NA |
| SETD2 | rucaparib | 0.6306943 | 0.9362277 | 0.63069 | NA | NA |
| MDM2 | nilotinib | 0.6317840 | 0.9362277 | 0.63178 | NA | NA |
| PIK3CA | temozolomide | 0.6319837 | 0.9362277 | 0.63198 | NA | NA |
| TPMT | afatinib | 0.6320485 | 0.9362277 | 0.63205 | NA | NA |
| ETV6 | lapatinib | 0.6320960 | 0.9362277 | 0.63210 | NA | NA |
| IDH1 | tretinoin | 0.6327016 | 0.9362277 | 0.63270 | NA | NA |
| FBXW7 | nilotinib | 0.6329663 | 0.9362277 | 0.63297 | NA | NA |
| SMO | erlotinib | 0.6333592 | 0.9362277 | 0.63336 | NA | NA |
| PIGA | ruxolitinib | 0.6341800 | 0.9362277 | 0.63418 | NA | NA |
| RIT1 | cabozantinib | 0.6344014 | 0.9362277 | 0.63440 | NA | NA |
| SETD2 | afatinib | 0.6344824 | 0.9362277 | 0.63448 | NA | NA |
| BCOR | tretinoin | 0.6346058 | 0.9362277 | 0.63461 | NA | NA |
| AKT1 | trametinib | 0.6346674 | 0.9362277 | 0.63467 | NA | NA |
| PAX5 | tretinoin | 0.6346748 | 0.9362277 | 0.63467 | NA | NA |
| EGFR | sunitinib | 0.6347395 | 0.9362277 | 0.63474 | NA | NA |
| ASXL1 | rucaparib | 0.6357840 | 0.9362277 | 0.63578 | NA | NA |
| CEBPA | belinostat | 0.6359932 | 0.9362277 | 0.63599 | NA | NA |
| PML | erlotinib | 0.6360548 | 0.9362277 | 0.63605 | NA | NA |
| SF3B1 | imatinib | 0.6360653 | 0.9362277 | 0.63607 | NA | NA |
| GATA2 | afatinib | 0.6361396 | 0.9362277 | 0.63614 | NA | NA |
| CREBBP | imatinib | 0.6365514 | 0.9363999 | 0.63655 | NA | NA |
| FANCL | gefitinib | 0.6370118 | 0.9366432 | 0.63701 | NA | NA |
| PDGFRB | alectinib | 0.6381495 | 0.9378819 | 0.63815 | NA | NA |
| PRPF40B | crizotinib | 0.6384729 | 0.9379232 | 0.63847 | NA | NA |
| GNAQ | ruxolitinib | 0.6391925 | 0.9385461 | 0.63919 | NA | NA |
| FLCN | dabrafenib | 0.6398583 | 0.9389000 | 0.63986 | NA | NA |
| PAX8 | nilotinib | 0.6400247 | 0.9389000 | 0.64002 | NA | NA |
| CD79B | rucaparib | 0.6412203 | 0.9397255 | 0.64122 | NA | NA |
| IL7R | afatinib | 0.6415553 | 0.9397255 | 0.64156 | NA | NA |
| RUNX1 | alectinib | 0.6416439 | 0.9397255 | 0.64164 | NA | NA |
| KRAS | imatinib | 0.6424818 | 0.9397255 | 0.64248 | NA | NA |
| FGFR3 | ruxolitinib | 0.6425963 | 0.9397255 | 0.64260 | NA | NA |
| FGFR2 | palbociclib | 0.6430949 | 0.9397255 | 0.64309 | NA | NA |
| SH2B3 | palbociclib | 0.6434247 | 0.9397255 | 0.64342 | NA | NA |
| MGMT | sunitinib | 0.6441449 | 0.9397255 | 0.64414 | NA | NA |
| PTPN11 | dabrafenib | 0.6445988 | 0.9397255 | 0.64460 | NA | NA |
| CD79B | trametinib | 0.6446579 | 0.9397255 | 0.64466 | NA | NA |
| EGFR | ruxolitinib | 0.6447588 | 0.9397255 | 0.64476 | NA | NA |
| NPM1 | rucaparib | 0.6448258 | 0.9397255 | 0.64483 | NA | NA |
| DNMT3A | ponatinib | 0.6448404 | 0.9397255 | 0.64484 | NA | NA |
| PHF6 | rucaparib | 0.6451245 | 0.9397255 | 0.64512 | NA | NA |
| KRAS | lapatinib | 0.6456344 | 0.9397255 | 0.64563 | NA | NA |
| XPO1 | ponatinib | 0.6457762 | 0.9397255 | 0.64578 | NA | NA |
| ZRSR2 | midostaurin | 0.6464003 | 0.9397255 | 0.64640 | NA | NA |
| MYCN | afatinib | 0.6464575 | 0.9397255 | 0.64646 | NA | NA |
| UGT1A1 | gefitinib | 0.6466857 | 0.9397255 | 0.64669 | NA | NA |
| EZH2 | midostaurin | 0.6468498 | 0.9397255 | 0.64685 | NA | NA |
| PDGFB | rucaparib | 0.6469333 | 0.9397255 | 0.64693 | NA | NA |
| PTPN11 | trametinib | 0.6470969 | 0.9397255 | 0.64710 | NA | NA |
| CD274 | ponatinib | 0.6479420 | 0.9405228 | 0.64794 | NA | NA |
| ALK | docetaxel | 0.6482988 | 0.9406108 | 0.64830 | NA | NA |
| CEBPA | temozolomide | 0.6502677 | 0.9426490 | 0.65027 | NA | NA |
| PRPF8 | sunitinib | 0.6502972 | 0.9426490 | 0.65030 | NA | NA |
| CBLB | gefitinib | 0.6512627 | 0.9436178 | 0.65126 | NA | NA |
| PTEN | afatinib | 0.6523280 | 0.9440395 | 0.65233 | NA | NA |
| FLT3 | midostaurin | 0.6526579 | 0.9440395 | 0.65266 | NA | NA |
| ERBB3 | ruxolitinib | 0.6532068 | 0.9440395 | 0.65321 | NA | NA |
| TSC2 | gefitinib | 0.6534622 | 0.9440395 | 0.65346 | NA | NA |
| UGT1A1 | alectinib | 0.6542466 | 0.9440395 | 0.65425 | NA | NA |
| CTLA4 | ruxolitinib | 0.6543284 | 0.9440395 | 0.65433 | NA | NA |
| TSC2 | bosutinib monohydrate | 0.6543872 | 0.9440395 | 0.65439 | NA | NA |
| SETBP1 | lapatinib | 0.6547184 | 0.9440395 | 0.65472 | NA | NA |
| BCOR | pazopanib | 0.6547699 | 0.9440395 | 0.65477 | NA | NA |
| GATA3 | belinostat | 0.6548206 | 0.9440395 | 0.65482 | NA | NA |
| MAP2K1 | sunitinib | 0.6551799 | 0.9440395 | 0.65518 | NA | NA |
| SF1 | trametinib | 0.6556570 | 0.9440395 | 0.65566 | NA | NA |
| SF1 | dabrafenib | 0.6557616 | 0.9440395 | 0.65576 | NA | NA |
| SMC1A | docetaxel | 0.6559586 | 0.9440395 | 0.65596 | NA | NA |
| STAG2 | trametinib | 0.6561590 | 0.9440395 | 0.65616 | NA | NA |
| MDM2 | pazopanib | 0.6563096 | 0.9440395 | 0.65631 | NA | NA |
| NOTCH2 | alectinib | 0.6570045 | 0.9446113 | 0.65700 | NA | NA |
| SMC1A | dabrafenib | 0.6573321 | 0.9446546 | 0.65733 | NA | NA |
| IKZF1 | pazopanib | 0.6580499 | 0.9452210 | 0.65805 | NA | NA |
| KIT | sunitinib | 0.6583214 | 0.9452210 | 0.65832 | NA | NA |
| MPL | trametinib | 0.6589843 | 0.9455176 | 0.65898 | NA | NA |
| FGFR1 | nilotinib | 0.6591234 | 0.9455176 | 0.65912 | NA | NA |
| PTCH1 | crizotinib | 0.6605698 | 0.9471647 | 0.66057 | NA | NA |
| GATA3 | tretinoin | 0.6613899 | 0.9474547 | 0.66139 | NA | NA |
| FGFR3 | pazopanib | 0.6614324 | 0.9474547 | 0.66143 | NA | NA |
| CBL | bosutinib monohydrate | 0.6620191 | 0.9474547 | 0.66202 | NA | NA |
| IL7R | palbociclib | 0.6625578 | 0.9474547 | 0.66256 | NA | NA |
| PDGFRB | pazopanib | 0.6626651 | 0.9474547 | 0.66267 | NA | NA |
| JAK1 | gefitinib | 0.6632200 | 0.9474547 | 0.66322 | NA | NA |
| FLCN | docetaxel | 0.6632639 | 0.9474547 | 0.66326 | NA | NA |
| IDH2 | erlotinib | 0.6634451 | 0.9474547 | 0.66345 | NA | NA |
| MGMT | temozolomide | 0.6634570 | 0.9474547 | 0.66346 | NA | NA |
| NT5C2 | ruxolitinib | 0.6648061 | 0.9483401 | 0.66481 | NA | NA |
| ALK | vismodegib | 0.6657344 | 0.9483401 | 0.66573 | NA | NA |
| ASXL1 | tretinoin | 0.6667178 | 0.9483401 | 0.66672 | NA | NA |
| CREBBP | nilotinib | 0.6672208 | 0.9483401 | 0.66722 | NA | NA |
| PIGA | docetaxel | 0.6672514 | 0.9483401 | 0.66725 | NA | NA |
| MYD88 | palbociclib | 0.6675616 | 0.9483401 | 0.66756 | NA | NA |
| DDIT3 | temozolomide | 0.6680811 | 0.9483401 | 0.66808 | NA | NA |
| GATA2 | temozolomide | 0.6681305 | 0.9483401 | 0.66813 | NA | NA |
| BCOR | dabrafenib | 0.6681638 | 0.9483401 | 0.66816 | NA | NA |
| CTLA4 | midostaurin | 0.6682026 | 0.9483401 | 0.66820 | NA | NA |
| FLT3 | belinostat | 0.6686147 | 0.9483401 | 0.66861 | NA | NA |
| FLT3 | ponatinib | 0.6691061 | 0.9483401 | 0.66911 | NA | NA |
| SMO | cabozantinib | 0.6697490 | 0.9483401 | 0.66975 | NA | NA |
| U2AF1 | midostaurin | 0.6708859 | 0.9483401 | 0.67089 | NA | NA |
| CTNNB1 | erlotinib | 0.6709344 | 0.9483401 | 0.67093 | NA | NA |
| IDH1 | ponatinib | 0.6713059 | 0.9483401 | 0.67131 | NA | NA |
| PDGFB | crizotinib | 0.6714054 | 0.9483401 | 0.67141 | NA | NA |
| CTNNB1 | crizotinib | 0.6714723 | 0.9483401 | 0.67147 | NA | NA |
| JAK1 | belinostat | 0.6717499 | 0.9483401 | 0.67175 | NA | NA |
| DNMT3A | dabrafenib | 0.6722330 | 0.9483401 | 0.67223 | NA | NA |
| PRPF40B | bosutinib monohydrate | 0.6722945 | 0.9483401 | 0.67229 | NA | NA |
| FLT3 | docetaxel | 0.6723654 | 0.9483401 | 0.67237 | NA | NA |
| MET | ruxolitinib | 0.6724758 | 0.9483401 | 0.67248 | NA | NA |
| HRAS | midostaurin | 0.6727624 | 0.9483401 | 0.67276 | NA | NA |
| ROS1 | pazopanib | 0.6730661 | 0.9483401 | 0.67307 | NA | NA |
| CTCF | lapatinib | 0.6732294 | 0.9483401 | 0.67323 | NA | NA |
| TET2 | trametinib | 0.6734045 | 0.9483401 | 0.67340 | NA | NA |
| CBL | pazopanib | 0.6735525 | 0.9483401 | 0.67355 | NA | NA |
| CXCR4 | belinostat | 0.6735809 | 0.9483401 | 0.67358 | NA | NA |
| MAP2K1 | palbociclib | 0.6736365 | 0.9483401 | 0.67364 | NA | NA |
| NRAS | rucaparib | 0.6737269 | 0.9483401 | 0.67373 | NA | NA |
| BRCA2 | nilotinib | 0.6739857 | 0.9483401 | 0.67399 | NA | NA |
| XPO1 | cabozantinib | 0.6741548 | 0.9483401 | 0.67415 | NA | NA |
| HRAS | afatinib | 0.6742292 | 0.9483401 | 0.67423 | NA | NA |
| JAK3 | vismodegib | 0.6747353 | 0.9485643 | 0.67474 | NA | NA |
| ROS1 | temozolomide | 0.6751390 | 0.9485643 | 0.67514 | NA | NA |
| PML | gefitinib | 0.6752846 | 0.9485643 | 0.67528 | NA | NA |
| PDCD1 | belinostat | 0.6759501 | 0.9487916 | 0.67595 | NA | NA |
| CDK4 | rucaparib | 0.6760802 | 0.9487916 | 0.67608 | NA | NA |
| SH2B3 | temozolomide | 0.6764609 | 0.9487916 | 0.67646 | NA | NA |
| AKT1 | rucaparib | 0.6766724 | 0.9487916 | 0.67667 | NA | NA |
| CDKN2A | nilotinib | 0.6769401 | 0.9487916 | 0.67694 | NA | NA |
| CRLF2 | nilotinib | 0.6773888 | 0.9488401 | 0.67739 | NA | NA |
| EML4 | trametinib | 0.6775722 | 0.9488401 | 0.67757 | NA | NA |
| EGFR | belinostat | 0.6783585 | 0.9493302 | 0.67836 | NA | NA |
| STAT3 | lapatinib | 0.6790984 | 0.9493302 | 0.67910 | NA | NA |
| NT5C2 | bosutinib monohydrate | 0.6791919 | 0.9493302 | 0.67919 | NA | NA |
| CDKN2A | sunitinib | 0.6799349 | 0.9493302 | 0.67993 | NA | NA |
| ESR1 | dasatinib | 0.6806688 | 0.9493302 | 0.68067 | NA | NA |
| PAX5 | nilotinib | 0.6809647 | 0.9493302 | 0.68096 | NA | NA |
| SF1 | midostaurin | 0.6811779 | 0.9493302 | 0.68118 | NA | NA |
| ERBB2 | rucaparib | 0.6813788 | 0.9493302 | 0.68138 | NA | NA |
| ESR1 | lapatinib | 0.6823352 | 0.9493302 | 0.68234 | NA | NA |
| PDGFRA | erlotinib | 0.6824019 | 0.9493302 | 0.68240 | NA | NA |
| PDGFRA | ponatinib | 0.6831311 | 0.9493302 | 0.68313 | NA | NA |
| ESR1 | midostaurin | 0.6835330 | 0.9493302 | 0.68353 | NA | NA |
| CEBPA | dabrafenib | 0.6842945 | 0.9493302 | 0.68429 | NA | NA |
| ESR1 | tretinoin | 0.6845216 | 0.9493302 | 0.68452 | NA | NA |
| BRCA1 | dabrafenib | 0.6846752 | 0.9493302 | 0.68468 | NA | NA |
| KRAS | rucaparib | 0.6847697 | 0.9493302 | 0.68477 | NA | NA |
| BRCA1 | palbociclib | 0.6850052 | 0.9493302 | 0.68501 | NA | NA |
| CBLB | nilotinib | 0.6856568 | 0.9493302 | 0.68566 | NA | NA |
| SF3B1 | belinostat | 0.6860819 | 0.9493302 | 0.68608 | NA | NA |
| CD79B | erlotinib | 0.6861034 | 0.9493302 | 0.68610 | NA | NA |
| DNAJB1 | erlotinib | 0.6861034 | 0.9493302 | 0.68610 | NA | NA |
| GNAQ | erlotinib | 0.6861034 | 0.9493302 | 0.68610 | NA | NA |
| MPL | erlotinib | 0.6862166 | 0.9493302 | 0.68622 | NA | NA |
| NOTCH2 | erlotinib | 0.6862166 | 0.9493302 | 0.68622 | NA | NA |
| FBXW7 | tretinoin | 0.6863672 | 0.9493302 | 0.68637 | NA | NA |
| IDH1 | pazopanib | 0.6864256 | 0.9493302 | 0.68643 | NA | NA |
| FGFR3 | imatinib | 0.6868047 | 0.9493302 | 0.68680 | NA | NA |
| CALR | gefitinib | 0.6884355 | 0.9493302 | 0.68844 | NA | NA |
| JAK1 | trametinib | 0.6886991 | 0.9493302 | 0.68870 | NA | NA |
| ERBB4 | nilotinib | 0.6889474 | 0.9493302 | 0.68895 | NA | NA |
| RET | belinostat | 0.6890334 | 0.9493302 | 0.68903 | NA | NA |
| RAD21 | docetaxel | 0.6893317 | 0.9493302 | 0.68933 | NA | NA |
| U2AF1 | dasatinib | 0.6894250 | 0.9493302 | 0.68943 | NA | NA |
| IKZF1 | cabozantinib | 0.6895685 | 0.9493302 | 0.68957 | NA | NA |
| MYD88 | crizotinib | 0.6896981 | 0.9493302 | 0.68970 | NA | NA |
| PHF6 | bosutinib monohydrate | 0.6899414 | 0.9493302 | 0.68994 | NA | NA |
| GATA3 | ponatinib | 0.6899584 | 0.9493302 | 0.68996 | NA | NA |
| IL7R | dabrafenib | 0.6901632 | 0.9493302 | 0.69016 | NA | NA |
| CYP19A1 | bosutinib monohydrate | 0.6902719 | 0.9493302 | 0.69027 | NA | NA |
| MGMT | pazopanib | 0.6911734 | 0.9493302 | 0.69117 | NA | NA |
| EML4 | midostaurin | 0.6914164 | 0.9493302 | 0.69142 | NA | NA |
| RUNX1 | pazopanib | 0.6915374 | 0.9493302 | 0.69154 | NA | NA |
| ALK | alectinib | 0.6916060 | 0.9493302 | 0.69161 | NA | NA |
| MET | temozolomide | 0.6917583 | 0.9493302 | 0.69176 | NA | NA |
| ESR1 | pazopanib | 0.6922709 | 0.9493302 | 0.69227 | NA | NA |
| PML | cabozantinib | 0.6926459 | 0.9493302 | 0.69265 | NA | NA |
| PAX8 | vismodegib | 0.6926534 | 0.9493302 | 0.69265 | NA | NA |
| CD274 | bosutinib monohydrate | 0.6927838 | 0.9493302 | 0.69278 | NA | NA |
| PDGFB | cabozantinib | 0.6931930 | 0.9493302 | 0.69319 | NA | NA |
| SF3B1 | ruxolitinib | 0.6933953 | 0.9493302 | 0.69340 | NA | NA |
| PTEN | bosutinib monohydrate | 0.6935476 | 0.9493302 | 0.69355 | NA | NA |
| EZH2 | sunitinib | 0.6938567 | 0.9493302 | 0.69386 | NA | NA |
| CALR | afatinib | 0.6938848 | 0.9493302 | 0.69388 | NA | NA |
| NCOA2 | dasatinib | 0.6940632 | 0.9493302 | 0.69406 | NA | NA |
| CSF3R | gefitinib | 0.6946468 | 0.9496794 | 0.69465 | NA | NA |
| RAD21 | lapatinib | 0.6950648 | 0.9496794 | 0.69506 | NA | NA |
| SSX1 | afatinib | 0.6952155 | 0.9496794 | 0.69522 | NA | NA |
| PRPF8 | palbociclib | 0.6959597 | 0.9499624 | 0.69596 | NA | NA |
| ESR1 | trametinib | 0.6962680 | 0.9499624 | 0.69627 | NA | NA |
| RAD21 | imatinib | 0.6963200 | 0.9499624 | 0.69632 | NA | NA |
| SMC3 | trametinib | 0.6972222 | 0.9506681 | 0.69722 | NA | NA |
| CDKN2A | cabozantinib | 0.6975307 | 0.9506681 | 0.69753 | NA | NA |
| SF3B1 | alectinib | 0.6977353 | 0.9506681 | 0.69774 | NA | NA |
| FGFR2 | gefitinib | 0.6980616 | 0.9507048 | 0.69806 | NA | NA |
| ABL1 | temozolomide | 0.6987934 | 0.9508786 | 0.69879 | NA | NA |
| CTLA4 | pazopanib | 0.6992202 | 0.9508786 | 0.69922 | NA | NA |
| BRCA1 | docetaxel | 0.7001716 | 0.9508786 | 0.70017 | NA | NA |
| SMC1A | trametinib | 0.7004160 | 0.9508786 | 0.70042 | NA | NA |
| GATA1 | belinostat | 0.7010507 | 0.9508786 | 0.70105 | NA | NA |
| BRCA1 | crizotinib | 0.7017863 | 0.9508786 | 0.70179 | NA | NA |
| CRLF2 | temozolomide | 0.7018756 | 0.9508786 | 0.70188 | NA | NA |
| TET2 | belinostat | 0.7026106 | 0.9508786 | 0.70261 | NA | NA |
| PML | dasatinib | 0.7028188 | 0.9508786 | 0.70282 | NA | NA |
| KMT2A | afatinib | 0.7030506 | 0.9508786 | 0.70305 | NA | NA |
| NOTCH2 | sunitinib | 0.7032998 | 0.9508786 | 0.70330 | NA | NA |
| TSC1 | dasatinib | 0.7033301 | 0.9508786 | 0.70333 | NA | NA |
| EZH2 | trametinib | 0.7036019 | 0.9508786 | 0.70360 | NA | NA |
| ETV6 | midostaurin | 0.7039964 | 0.9508786 | 0.70400 | NA | NA |
| G6PD | crizotinib | 0.7040235 | 0.9508786 | 0.70402 | NA | NA |
| TET2 | palbociclib | 0.7041197 | 0.9508786 | 0.70412 | NA | NA |
| GNB1 | tretinoin | 0.7042251 | 0.9508786 | 0.70423 | NA | NA |
| HRAS | dabrafenib | 0.7049847 | 0.9508786 | 0.70498 | NA | NA |
| FLCN | palbociclib | 0.7051976 | 0.9508786 | 0.70520 | NA | NA |
| ERBB2 | docetaxel | 0.7052502 | 0.9508786 | 0.70525 | NA | NA |
| SRSF2 | trametinib | 0.7053488 | 0.9508786 | 0.70535 | NA | NA |
| GNAS | afatinib | 0.7054184 | 0.9508786 | 0.70542 | NA | NA |
| WT1 | afatinib | 0.7062470 | 0.9508786 | 0.70625 | NA | NA |
| UGT1A1 | ponatinib | 0.7062488 | 0.9508786 | 0.70625 | NA | NA |
| CTNNB1 | tretinoin | 0.7063175 | 0.9508786 | 0.70632 | NA | NA |
| CSF3R | afatinib | 0.7063490 | 0.9508786 | 0.70635 | NA | NA |
| CBL | tretinoin | 0.7065815 | 0.9508786 | 0.70658 | NA | NA |
| STAT3 | docetaxel | 0.7071045 | 0.9508786 | 0.70710 | NA | NA |
| IL7R | cabozantinib | 0.7075726 | 0.9508786 | 0.70757 | NA | NA |
| ROS1 | vismodegib | 0.7075936 | 0.9508786 | 0.70759 | NA | NA |
| ERBB2 | palbociclib | 0.7083268 | 0.9508786 | 0.70833 | NA | NA |
| FBXW7 | sunitinib | 0.7083621 | 0.9508786 | 0.70836 | NA | NA |
| NOTCH1 | midostaurin | 0.7089128 | 0.9508786 | 0.70891 | NA | NA |
| TSC2 | belinostat | 0.7089749 | 0.9508786 | 0.70897 | NA | NA |
| IDH2 | dasatinib | 0.7090830 | 0.9508786 | 0.70908 | NA | NA |
| PRPF40B | cabozantinib | 0.7092004 | 0.9508786 | 0.70920 | NA | NA |
| ALK | erlotinib | 0.7099827 | 0.9508786 | 0.70998 | NA | NA |
| JAK2 | dasatinib | 0.7103203 | 0.9508786 | 0.71032 | NA | NA |
| RET | dabrafenib | 0.7105653 | 0.9508786 | 0.71057 | NA | NA |
| FGFR2 | rucaparib | 0.7108197 | 0.9508786 | 0.71082 | NA | NA |
| GATA3 | pazopanib | 0.7109684 | 0.9508786 | 0.71097 | NA | NA |
| HRAS | rucaparib | 0.7110377 | 0.9508786 | 0.71104 | NA | NA |
| U2AF1 | dabrafenib | 0.7110632 | 0.9508786 | 0.71106 | NA | NA |
| STAG2 | docetaxel | 0.7117563 | 0.9510210 | 0.71176 | NA | NA |
| RUNX1 | crizotinib | 0.7117686 | 0.9510210 | 0.71177 | NA | NA |
| PIK3CA | alectinib | 0.7127369 | 0.9518052 | 0.71274 | NA | NA |
| BTK | midostaurin | 0.7129549 | 0.9518052 | 0.71295 | NA | NA |
| KRAS | ruxolitinib | 0.7137147 | 0.9519250 | 0.71371 | NA | NA |
| SETBP1 | dasatinib | 0.7145822 | 0.9519250 | 0.71458 | NA | NA |
| WT1 | ponatinib | 0.7147828 | 0.9519250 | 0.71478 | NA | NA |
| RET | dasatinib | 0.7148163 | 0.9519250 | 0.71482 | NA | NA |
| IKZF1 | lapatinib | 0.7149708 | 0.9519250 | 0.71497 | NA | NA |
| KRAS | temozolomide | 0.7150718 | 0.9519250 | 0.71507 | NA | NA |
| SF3B1 | dabrafenib | 0.7152721 | 0.9519250 | 0.71527 | NA | NA |
| ESR1 | cabozantinib | 0.7161231 | 0.9519250 | 0.71612 | NA | NA |
| ERBB4 | midostaurin | 0.7168444 | 0.9519250 | 0.71684 | NA | NA |
| BTK | dasatinib | 0.7173351 | 0.9519250 | 0.71734 | NA | NA |
| PAX8 | dasatinib | 0.7173351 | 0.9519250 | 0.71734 | NA | NA |
| FGFR1 | vismodegib | 0.7176988 | 0.9519250 | 0.71770 | NA | NA |
| WHSC1 | pazopanib | 0.7177667 | 0.9519250 | 0.71777 | NA | NA |
| CDK4 | ponatinib | 0.7179383 | 0.9519250 | 0.71794 | NA | NA |
| CBL | trametinib | 0.7179539 | 0.9519250 | 0.71795 | NA | NA |
| CRLF2 | trametinib | 0.7189639 | 0.9519250 | 0.71896 | NA | NA |
| SETBP1 | ruxolitinib | 0.7191346 | 0.9519250 | 0.71913 | NA | NA |
| AR | belinostat | 0.7191374 | 0.9519250 | 0.71914 | NA | NA |
| PAX8 | tretinoin | 0.7192167 | 0.9519250 | 0.71922 | NA | NA |
| EGFR | trametinib | 0.7194767 | 0.9519250 | 0.71948 | NA | NA |
| NRAS | temozolomide | 0.7197845 | 0.9519250 | 0.71978 | NA | NA |
| PTCH1 | vismodegib | 0.7198241 | 0.9519250 | 0.71982 | NA | NA |
| JAK3 | pazopanib | 0.7199383 | 0.9519250 | 0.71994 | NA | NA |
| ERBB3 | erlotinib | 0.7203169 | 0.9519798 | 0.72032 | NA | NA |
| HRAS | temozolomide | 0.7205791 | 0.9519798 | 0.72058 | NA | NA |
| SMO | dabrafenib | 0.7212576 | 0.9524799 | 0.72126 | NA | NA |
| MYCN | palbociclib | 0.7218549 | 0.9525777 | 0.72185 | NA | NA |
| CD274 | palbociclib | 0.7221370 | 0.9525777 | 0.72214 | NA | NA |
| CD274 | gefitinib | 0.7222314 | 0.9525777 | 0.72223 | NA | NA |
| MAP2K1 | gefitinib | 0.7231455 | 0.9533874 | 0.72315 | NA | NA |
| SMO | sunitinib | 0.7239446 | 0.9537902 | 0.72394 | NA | NA |
| PDGFRB | ponatinib | 0.7240517 | 0.9537902 | 0.72405 | NA | NA |
| RUNX1 | gefitinib | 0.7245837 | 0.9538586 | 0.72458 | NA | NA |
| SMO | pazopanib | 0.7247577 | 0.9538586 | 0.72476 | NA | NA |
| MAP2K1 | pazopanib | 0.7253435 | 0.9538586 | 0.72534 | NA | NA |
| NOTCH1 | crizotinib | 0.7257254 | 0.9538586 | 0.72573 | NA | NA |
| EED | midostaurin | 0.7259376 | 0.9538586 | 0.72594 | NA | NA |
| FLCN | vismodegib | 0.7262828 | 0.9538586 | 0.72628 | NA | NA |
| ERBB3 | rucaparib | 0.7263040 | 0.9538586 | 0.72630 | NA | NA |
| GNA11 | dabrafenib | 0.7266549 | 0.9538586 | 0.72665 | NA | NA |
| PHF6 | vismodegib | 0.7268066 | 0.9538586 | 0.72681 | NA | NA |
| MDM2 | vismodegib | 0.7273768 | 0.9538611 | 0.72738 | NA | NA |
| CBLB | tretinoin | 0.7276859 | 0.9538611 | 0.72769 | NA | NA |
| GNAQ | gefitinib | 0.7280594 | 0.9538611 | 0.72806 | NA | NA |
| FGFR2 | ruxolitinib | 0.7282503 | 0.9538611 | 0.72825 | NA | NA |
| DPYD | pazopanib | 0.7284979 | 0.9538611 | 0.72850 | NA | NA |
| EML4 | afatinib | 0.7287764 | 0.9538611 | 0.72878 | NA | NA |
| PRPF8 | bosutinib monohydrate | 0.7291900 | 0.9538611 | 0.72919 | NA | NA |
| SMC3 | pazopanib | 0.7292112 | 0.9538611 | 0.72921 | NA | NA |
| PDGFRB | palbociclib | 0.7303977 | 0.9547064 | 0.73040 | NA | NA |
| ABL1 | nilotinib | 0.7313136 | 0.9547064 | 0.73131 | NA | NA |
| GATA3 | docetaxel | 0.7316455 | 0.9547064 | 0.73165 | NA | NA |
| NT5C2 | erlotinib | 0.7318780 | 0.9547064 | 0.73188 | NA | NA |
| RUNX1 | erlotinib | 0.7318780 | 0.9547064 | 0.73188 | NA | NA |
| CXCR4 | vismodegib | 0.7331174 | 0.9547064 | 0.73312 | NA | NA |
| BRAF | temozolomide | 0.7335771 | 0.9547064 | 0.73358 | NA | NA |
| GATA2 | ponatinib | 0.7335798 | 0.9547064 | 0.73358 | NA | NA |
| PIK3CA | vismodegib | 0.7343535 | 0.9547064 | 0.73435 | NA | NA |
| EGFR | docetaxel | 0.7346881 | 0.9547064 | 0.73469 | NA | NA |
| FLCN | ponatinib | 0.7349618 | 0.9547064 | 0.73496 | NA | NA |
| PML | ruxolitinib | 0.7351319 | 0.9547064 | 0.73513 | NA | NA |
| FANCL | rucaparib | 0.7358289 | 0.9547064 | 0.73583 | NA | NA |
| CBLB | pazopanib | 0.7358844 | 0.9547064 | 0.73588 | NA | NA |
| IL7R | gefitinib | 0.7358963 | 0.9547064 | 0.73590 | NA | NA |
| WT1 | alectinib | 0.7365097 | 0.9547064 | 0.73651 | NA | NA |
| FANCL | sunitinib | 0.7369648 | 0.9547064 | 0.73696 | NA | NA |
| CBL | ponatinib | 0.7373495 | 0.9547064 | 0.73735 | NA | NA |
| CEBPA | docetaxel | 0.7376323 | 0.9547064 | 0.73763 | NA | NA |
| CYP19A1 | temozolomide | 0.7376987 | 0.9547064 | 0.73770 | NA | NA |
| CDK4 | tretinoin | 0.7381800 | 0.9547064 | 0.73818 | NA | NA |
| PAX5 | midostaurin | 0.7382339 | 0.9547064 | 0.73823 | NA | NA |
| PRPF40B | ponatinib | 0.7385033 | 0.9547064 | 0.73850 | NA | NA |
| PDGFRA | crizotinib | 0.7390621 | 0.9547064 | 0.73906 | NA | NA |
| CREBBP | crizotinib | 0.7392861 | 0.9547064 | 0.73929 | NA | NA |
| FLCN | nilotinib | 0.7393663 | 0.9547064 | 0.73937 | NA | NA |
| SETBP1 | tretinoin | 0.7395737 | 0.9547064 | 0.73957 | NA | NA |
| CSF3R | rucaparib | 0.7397162 | 0.9547064 | 0.73972 | NA | NA |
| EGF | sunitinib | 0.7398358 | 0.9547064 | 0.73984 | NA | NA |
| IL7R | sunitinib | 0.7398358 | 0.9547064 | 0.73984 | NA | NA |
| KIT | dasatinib | 0.7398951 | 0.9547064 | 0.73990 | NA | NA |
| CDK4 | belinostat | 0.7399640 | 0.9547064 | 0.73996 | NA | NA |
| ERBB3 | crizotinib | 0.7406129 | 0.9547064 | 0.74061 | NA | NA |
| AKT1 | afatinib | 0.7407741 | 0.9547064 | 0.74077 | NA | NA |
| CALR | vismodegib | 0.7414134 | 0.9547064 | 0.74141 | NA | NA |
| DPYD | sunitinib | 0.7414533 | 0.9547064 | 0.74145 | NA | NA |
| KRAS | bosutinib monohydrate | 0.7414809 | 0.9547064 | 0.74148 | NA | NA |
| CTLA4 | dabrafenib | 0.7416236 | 0.9547064 | 0.74162 | NA | NA |
| TSC1 | cabozantinib | 0.7417760 | 0.9547064 | 0.74178 | NA | NA |
| PIGA | tretinoin | 0.7420835 | 0.9547064 | 0.74208 | NA | NA |
| CYP19A1 | ponatinib | 0.7421820 | 0.9547064 | 0.74218 | NA | NA |
| PDGFRB | bosutinib monohydrate | 0.7429860 | 0.9547601 | 0.74299 | NA | NA |
| GATA3 | afatinib | 0.7430967 | 0.9547601 | 0.74310 | NA | NA |
| NOTCH2 | palbociclib | 0.7431256 | 0.9547601 | 0.74313 | NA | NA |
| IDH2 | imatinib | 0.7435570 | 0.9549281 | 0.74356 | NA | NA |
| FANCL | bosutinib monohydrate | 0.7442638 | 0.9554494 | 0.74426 | NA | NA |
| CSF3R | imatinib | 0.7445896 | 0.9554815 | 0.74459 | NA | NA |
| PDGFRA | belinostat | 0.7450686 | 0.9557100 | 0.74507 | NA | NA |
| ASXL1 | lapatinib | 0.7456852 | 0.9558452 | 0.74569 | NA | NA |
| TPMT | midostaurin | 0.7460273 | 0.9558452 | 0.74603 | NA | NA |
| JAK3 | crizotinib | 0.7461407 | 0.9558452 | 0.74614 | NA | NA |
| PML | belinostat | 0.7463779 | 0.9558452 | 0.74638 | NA | NA |
| FBXW7 | dabrafenib | 0.7471349 | 0.9564291 | 0.74713 | NA | NA |
| SMO | bosutinib monohydrate | 0.7478513 | 0.9568582 | 0.74785 | NA | NA |
| SETD2 | tretinoin | 0.7482992 | 0.9568582 | 0.74830 | NA | NA |
| GATA2 | imatinib | 0.7483981 | 0.9568582 | 0.74840 | NA | NA |
| ATM | rucaparib | 0.7486752 | 0.9568582 | 0.74868 | NA | NA |
| BRCA1 | imatinib | 0.7500850 | 0.9578756 | 0.75008 | NA | NA |
| KIT | imatinib | 0.7505218 | 0.9578756 | 0.75052 | NA | NA |
| NOTCH1 | belinostat | 0.7507540 | 0.9578756 | 0.75075 | NA | NA |
| PDCD1 | midostaurin | 0.7514117 | 0.9578756 | 0.75141 | NA | NA |
| EGFR | palbociclib | 0.7514260 | 0.9578756 | 0.75143 | NA | NA |
| SETBP1 | erlotinib | 0.7514881 | 0.9578756 | 0.75149 | NA | NA |
| BTK | cabozantinib | 0.7515825 | 0.9578756 | 0.75158 | NA | NA |
| CDC73 | midostaurin | 0.7520422 | 0.9578798 | 0.75204 | NA | NA |
| MAP2K1 | rucaparib | 0.7521890 | 0.9578798 | 0.75219 | NA | NA |
| ERBB4 | tretinoin | 0.7532253 | 0.9580745 | 0.75323 | NA | NA |
| PHF6 | ruxolitinib | 0.7532871 | 0.9580745 | 0.75329 | NA | NA |
| MAP2K2 | afatinib | 0.7534845 | 0.9580745 | 0.75348 | NA | NA |
| ERBB4 | dabrafenib | 0.7535485 | 0.9580745 | 0.75355 | NA | NA |
| CREBBP | belinostat | 0.7547871 | 0.9592653 | 0.75479 | NA | NA |
| DNMT3A | bosutinib monohydrate | 0.7551741 | 0.9593731 | 0.75517 | NA | NA |
| SSX1 | dabrafenib | 0.7561779 | 0.9600555 | 0.75618 | NA | NA |
| MYCN | vismodegib | 0.7563157 | 0.9600555 | 0.75632 | NA | NA |
| NT5C2 | ponatinib | 0.7573545 | 0.9606710 | 0.75735 | NA | NA |
| MAP2K1 | lapatinib | 0.7574056 | 0.9606710 | 0.75741 | NA | NA |
| WHSC1 | gefitinib | 0.7582570 | 0.9610535 | 0.75826 | NA | NA |
| PDGFRA | pazopanib | 0.7583124 | 0.9610535 | 0.75831 | NA | NA |
| FGFR1 | bosutinib monohydrate | 0.7589059 | 0.9610856 | 0.75891 | NA | NA |
| CTNNB1 | pazopanib | 0.7592589 | 0.9610856 | 0.75926 | NA | NA |
| PIGA | alectinib | 0.7603016 | 0.9610856 | 0.76030 | NA | NA |
| PAX8 | rucaparib | 0.7606800 | 0.9610856 | 0.76068 | NA | NA |
| PTEN | nilotinib | 0.7611038 | 0.9610856 | 0.76110 | NA | NA |
| FANCL | midostaurin | 0.7611087 | 0.9610856 | 0.76111 | NA | NA |
| DNMT3A | alectinib | 0.7613631 | 0.9610856 | 0.76136 | NA | NA |
| TPMT | rucaparib | 0.7619662 | 0.9610856 | 0.76197 | NA | NA |
| GNAS | imatinib | 0.7623301 | 0.9610856 | 0.76233 | NA | NA |
| STAG2 | rucaparib | 0.7624445 | 0.9610856 | 0.76244 | NA | NA |
| AKT1 | gefitinib | 0.7625117 | 0.9610856 | 0.76251 | NA | NA |
| CDKN2A | dasatinib | 0.7625887 | 0.9610856 | 0.76259 | NA | NA |
| NCOA2 | trametinib | 0.7627476 | 0.9610856 | 0.76275 | NA | NA |
| G6PD | trametinib | 0.7631155 | 0.9610856 | 0.76312 | NA | NA |
| EGFR | pazopanib | 0.7631271 | 0.9610856 | 0.76313 | NA | NA |
| MGMT | alectinib | 0.7636616 | 0.9610856 | 0.76366 | NA | NA |
| PDGFB | bosutinib monohydrate | 0.7637526 | 0.9610856 | 0.76375 | NA | NA |
| KRAS | sunitinib | 0.7642647 | 0.9610856 | 0.76426 | NA | NA |
| CXCR4 | cabozantinib | 0.7645614 | 0.9610856 | 0.76456 | NA | NA |
| CTNNB1 | gefitinib | 0.7648316 | 0.9610856 | 0.76483 | NA | NA |
| PDGFRB | gefitinib | 0.7649324 | 0.9610856 | 0.76493 | NA | NA |
| WT1 | cabozantinib | 0.7656627 | 0.9610856 | 0.76566 | NA | NA |
| IDH1 | bosutinib monohydrate | 0.7658117 | 0.9610856 | 0.76581 | NA | NA |
| CBLB | alectinib | 0.7661083 | 0.9610856 | 0.76611 | NA | NA |
| IL7R | imatinib | 0.7661566 | 0.9610856 | 0.76616 | NA | NA |
| AKT2 | lapatinib | 0.7662055 | 0.9610856 | 0.76621 | NA | NA |
| CSF3R | nilotinib | 0.7665100 | 0.9610880 | 0.76651 | NA | NA |
| TPMT | palbociclib | 0.7668585 | 0.9611454 | 0.76686 | NA | NA |
| CYP19A1 | palbociclib | 0.7672395 | 0.9612437 | 0.76724 | NA | NA |
| ASXL1 | temozolomide | 0.7680740 | 0.9618479 | 0.76807 | NA | NA |
| CD79B | pazopanib | 0.7683275 | 0.9618479 | 0.76833 | NA | NA |
| PHF6 | pazopanib | 0.7688041 | 0.9620654 | 0.76880 | NA | NA |
| ETV6 | bosutinib monohydrate | 0.7705523 | 0.9638321 | 0.77055 | NA | NA |
| ABL1 | bosutinib monohydrate | 0.7708229 | 0.9638321 | 0.77082 | NA | NA |
| ALK | tretinoin | 0.7717427 | 0.9638929 | 0.77174 | NA | NA |
| PDGFRA | lapatinib | 0.7718304 | 0.9638929 | 0.77183 | NA | NA |
| RIT1 | ruxolitinib | 0.7720357 | 0.9638929 | 0.77204 | NA | NA |
| PDGFB | pazopanib | 0.7722360 | 0.9638929 | 0.77224 | NA | NA |
| AKT2 | afatinib | 0.7723890 | 0.9638929 | 0.77239 | NA | NA |
| SH2B3 | trametinib | 0.7727573 | 0.9639738 | 0.77276 | NA | NA |
| GNAQ | palbociclib | 0.7733014 | 0.9642737 | 0.77330 | NA | NA |
| SETBP1 | midostaurin | 0.7737089 | 0.9643370 | 0.77371 | NA | NA |
| ERBB2 | vismodegib | 0.7739594 | 0.9643370 | 0.77396 | NA | NA |
| KIT | docetaxel | 0.7747007 | 0.9648821 | 0.77470 | NA | NA |
| CDKN2A | vismodegib | 0.7751324 | 0.9649138 | 0.77513 | NA | NA |
| FGFR3 | ponatinib | 0.7753615 | 0.9649138 | 0.77536 | NA | NA |
| SSX1 | belinostat | 0.7759031 | 0.9649138 | 0.77590 | NA | NA |
| U2AF1 | sunitinib | 0.7759414 | 0.9649138 | 0.77594 | NA | NA |
| SMC3 | crizotinib | 0.7765258 | 0.9652626 | 0.77653 | NA | NA |
| PML | nilotinib | 0.7777017 | 0.9663461 | 0.77770 | NA | NA |
| IKZF1 | palbociclib | 0.7792127 | 0.9665666 | 0.77921 | NA | NA |
| GATA2 | rucaparib | 0.7793422 | 0.9665666 | 0.77934 | NA | NA |
| JAK1 | rucaparib | 0.7793843 | 0.9665666 | 0.77938 | NA | NA |
| EGF | crizotinib | 0.7795860 | 0.9665666 | 0.77959 | NA | NA |
| STAT3 | dabrafenib | 0.7798325 | 0.9665666 | 0.77983 | NA | NA |
| DPYD | tretinoin | 0.7806169 | 0.9665666 | 0.78062 | NA | NA |
| KMT2A | midostaurin | 0.7807486 | 0.9665666 | 0.78075 | NA | NA |
| JAK1 | dasatinib | 0.7807932 | 0.9665666 | 0.78079 | NA | NA |
| EGF | lapatinib | 0.7810119 | 0.9665666 | 0.78101 | NA | NA |
| EGFR | rucaparib | 0.7812134 | 0.9665666 | 0.78121 | NA | NA |
| TP53 | alectinib | 0.7812268 | 0.9665666 | 0.78123 | NA | NA |
| RAD21 | midostaurin | 0.7818238 | 0.9665981 | 0.78182 | NA | NA |
| RUNX1 | midostaurin | 0.7821353 | 0.9665981 | 0.78214 | NA | NA |
| ETV6 | palbociclib | 0.7821653 | 0.9665981 | 0.78217 | NA | NA |
| SSX1 | cabozantinib | 0.7843612 | 0.9689347 | 0.78436 | NA | NA |
| PRPF8 | docetaxel | 0.7851088 | 0.9692570 | 0.78511 | NA | NA |
| MET | rucaparib | 0.7852325 | 0.9692570 | 0.78523 | NA | NA |
| MYD88 | sunitinib | 0.7863908 | 0.9701455 | 0.78639 | NA | NA |
| IDH1 | temozolomide | 0.7871872 | 0.9701455 | 0.78719 | NA | NA |
| CD79B | nilotinib | 0.7872284 | 0.9701455 | 0.78723 | NA | NA |
| CXCR4 | tretinoin | 0.7873492 | 0.9701455 | 0.78735 | NA | NA |
| CBLB | ponatinib | 0.7877705 | 0.9701455 | 0.78777 | NA | NA |
| CTLA4 | belinostat | 0.7879627 | 0.9701455 | 0.78796 | NA | NA |
| NPM1 | pazopanib | 0.7880905 | 0.9701455 | 0.78809 | NA | NA |
| MYD88 | imatinib | 0.7889569 | 0.9708358 | 0.78896 | NA | NA |
| SH2B3 | docetaxel | 0.7897952 | 0.9714909 | 0.78980 | NA | NA |
| BRAF | ponatinib | 0.7903167 | 0.9717560 | 0.79032 | NA | NA |
| ASXL1 | midostaurin | 0.7907471 | 0.9719090 | 0.79075 | NA | NA |
| WHSC1 | lapatinib | 0.7912577 | 0.9721494 | 0.79126 | NA | NA |
| WHSC1 | bosutinib monohydrate | 0.7917104 | 0.9721494 | 0.79171 | NA | NA |
| BRCA1 | gefitinib | 0.7929047 | 0.9721494 | 0.79290 | NA | NA |
| TP53 | sunitinib | 0.7929103 | 0.9721494 | 0.79291 | NA | NA |
| DDIT3 | afatinib | 0.7931329 | 0.9721494 | 0.79313 | NA | NA |
| JAK1 | bosutinib monohydrate | 0.7934737 | 0.9721494 | 0.79347 | NA | NA |
| EGF | vismodegib | 0.7936091 | 0.9721494 | 0.79361 | NA | NA |
| NOTCH1 | dabrafenib | 0.7939637 | 0.9721494 | 0.79396 | NA | NA |
| SSX1 | ruxolitinib | 0.7939998 | 0.9721494 | 0.79400 | NA | NA |
| FLT3 | alectinib | 0.7941809 | 0.9721494 | 0.79418 | NA | NA |
| BRAF | midostaurin | 0.7943467 | 0.9721494 | 0.79435 | NA | NA |
| PAX8 | pazopanib | 0.7947477 | 0.9721494 | 0.79475 | NA | NA |
| AKT2 | nilotinib | 0.7949272 | 0.9721494 | 0.79493 | NA | NA |
| PTCH1 | rucaparib | 0.7952280 | 0.9721494 | 0.79523 | NA | NA |
| SH2B3 | pazopanib | 0.7956485 | 0.9722775 | 0.79565 | NA | NA |
| CDK6 | bosutinib monohydrate | 0.7961993 | 0.9722775 | 0.79620 | NA | NA |
| AKT2 | vismodegib | 0.7962512 | 0.9722775 | 0.79625 | NA | NA |
| MAP2K1 | dasatinib | 0.7966385 | 0.9723766 | 0.79664 | NA | NA |
| BCORL1 | trametinib | 0.7977582 | 0.9724415 | 0.79776 | NA | NA |
| PML | docetaxel | 0.7980096 | 0.9724415 | 0.79801 | NA | NA |
| AKT2 | belinostat | 0.7986070 | 0.9724415 | 0.79861 | NA | NA |
| ERBB4 | ruxolitinib | 0.7989163 | 0.9724415 | 0.79892 | NA | NA |
| AKT3 | nilotinib | 0.7991714 | 0.9724415 | 0.79917 | NA | NA |
| PRPF8 | dasatinib | 0.7991729 | 0.9724415 | 0.79917 | NA | NA |
| AKT2 | pazopanib | 0.7992674 | 0.9724415 | 0.79927 | NA | NA |
| BCOR | docetaxel | 0.7999167 | 0.9724415 | 0.79992 | NA | NA |
| SF1 | lapatinib | 0.8001540 | 0.9724415 | 0.80015 | NA | NA |
| NPM1 | vismodegib | 0.8004491 | 0.9724415 | 0.80045 | NA | NA |
| GATA3 | gefitinib | 0.8010561 | 0.9724415 | 0.80106 | NA | NA |
| SSX1 | bosutinib monohydrate | 0.8010644 | 0.9724415 | 0.80106 | NA | NA |
| DNAJB1 | ruxolitinib | 0.8017173 | 0.9724415 | 0.80172 | NA | NA |
| PDGFRB | crizotinib | 0.8019048 | 0.9724415 | 0.80190 | NA | NA |
| ERBB3 | trametinib | 0.8021031 | 0.9724415 | 0.80210 | NA | NA |
| MYCN | belinostat | 0.8021438 | 0.9724415 | 0.80214 | NA | NA |
| NOTCH1 | cabozantinib | 0.8021819 | 0.9724415 | 0.80218 | NA | NA |
| CDKN2A | tretinoin | 0.8022030 | 0.9724415 | 0.80220 | NA | NA |
| ERBB4 | bosutinib monohydrate | 0.8029349 | 0.9729574 | 0.80293 | NA | NA |
| NOTCH2 | ponatinib | 0.8034028 | 0.9730164 | 0.80340 | NA | NA |
| FLT3 | afatinib | 0.8043606 | 0.9730164 | 0.80436 | NA | NA |
| FLCN | tretinoin | 0.8043691 | 0.9730164 | 0.80437 | NA | NA |
| SETD2 | palbociclib | 0.8046290 | 0.9730164 | 0.80463 | NA | NA |
| JAK2 | sunitinib | 0.8046870 | 0.9730164 | 0.80469 | NA | NA |
| MPL | lapatinib | 0.8048218 | 0.9730164 | 0.80482 | NA | NA |
| STAT3 | bosutinib monohydrate | 0.8055766 | 0.9730983 | 0.80558 | NA | NA |
| PTPN11 | pazopanib | 0.8056289 | 0.9730983 | 0.80563 | NA | NA |
| KRAS | nilotinib | 0.8058237 | 0.9730983 | 0.80582 | NA | NA |
| IDH2 | nilotinib | 0.8061151 | 0.9730983 | 0.80612 | NA | NA |
| IDH2 | ruxolitinib | 0.8073056 | 0.9732165 | 0.80731 | NA | NA |
| HRAS | gefitinib | 0.8076126 | 0.9732165 | 0.80761 | NA | NA |
| FLT3 | tretinoin | 0.8076478 | 0.9732165 | 0.80765 | NA | NA |
| DPYD | belinostat | 0.8079628 | 0.9732165 | 0.80796 | NA | NA |
| ESR1 | bosutinib monohydrate | 0.8080005 | 0.9732165 | 0.80800 | NA | NA |
| CTLA4 | trametinib | 0.8080516 | 0.9732165 | 0.80805 | NA | NA |
| NRAS | docetaxel | 0.8083668 | 0.9732271 | 0.80837 | NA | NA |
| U2AF1 | gefitinib | 0.8094477 | 0.9739554 | 0.80945 | NA | NA |
| SETD2 | belinostat | 0.8095851 | 0.9739554 | 0.80959 | NA | NA |
| AKT3 | rucaparib | 0.8101446 | 0.9742595 | 0.81014 | NA | NA |
| PIGA | lapatinib | 0.8104666 | 0.9742777 | 0.81047 | NA | NA |
| DPYD | palbociclib | 0.8111267 | 0.9743982 | 0.81113 | NA | NA |
| IKZF1 | belinostat | 0.8113724 | 0.9743982 | 0.81137 | NA | NA |
| PTPN11 | vismodegib | 0.8117817 | 0.9743982 | 0.81178 | NA | NA |
| IL7R | vismodegib | 0.8119458 | 0.9743982 | 0.81195 | NA | NA |
| NT5C2 | trametinib | 0.8128743 | 0.9743982 | 0.81287 | NA | NA |
| AR | docetaxel | 0.8129175 | 0.9743982 | 0.81292 | NA | NA |
| WHSC1 | rucaparib | 0.8131544 | 0.9743982 | 0.81315 | NA | NA |
| VHL | docetaxel | 0.8136685 | 0.9743982 | 0.81367 | NA | NA |
| PTEN | dabrafenib | 0.8142047 | 0.9743982 | 0.81420 | NA | NA |
| GNA11 | temozolomide | 0.8144730 | 0.9743982 | 0.81447 | NA | NA |
| PRPF8 | dabrafenib | 0.8146043 | 0.9743982 | 0.81460 | NA | NA |
| HRAS | docetaxel | 0.8151657 | 0.9743982 | 0.81517 | NA | NA |
| CREBBP | lapatinib | 0.8151862 | 0.9743982 | 0.81519 | NA | NA |
| NOTCH1 | imatinib | 0.8157654 | 0.9743982 | 0.81577 | NA | NA |
| RET | temozolomide | 0.8158960 | 0.9743982 | 0.81590 | NA | NA |
| XPO1 | gefitinib | 0.8161735 | 0.9743982 | 0.81617 | NA | NA |
| TET2 | pazopanib | 0.8164348 | 0.9743982 | 0.81643 | NA | NA |
| BRCA1 | sunitinib | 0.8165800 | 0.9743982 | 0.81658 | NA | NA |
| PHF6 | midostaurin | 0.8168214 | 0.9743982 | 0.81682 | NA | NA |
| PTPN11 | tretinoin | 0.8170201 | 0.9743982 | 0.81702 | NA | NA |
| PRPF40B | lapatinib | 0.8171082 | 0.9743982 | 0.81711 | NA | NA |
| ETV6 | docetaxel | 0.8173164 | 0.9743982 | 0.81732 | NA | NA |
| ZRSR2 | erlotinib | 0.8179957 | 0.9744526 | 0.81800 | NA | NA |
| ERBB3 | dasatinib | 0.8180600 | 0.9744526 | 0.81806 | NA | NA |
| PRPF8 | nilotinib | 0.8182825 | 0.9744526 | 0.81828 | NA | NA |
| G6PD | gefitinib | 0.8202116 | 0.9752458 | 0.82021 | NA | NA |
| ETV6 | dasatinib | 0.8204783 | 0.9752458 | 0.82048 | NA | NA |
| CREBBP | erlotinib | 0.8208508 | 0.9752458 | 0.82085 | NA | NA |
| CREBBP | bosutinib monohydrate | 0.8213056 | 0.9752458 | 0.82131 | NA | NA |
| AKT2 | cabozantinib | 0.8215110 | 0.9752458 | 0.82151 | NA | NA |
| SRSF2 | bosutinib monohydrate | 0.8216022 | 0.9752458 | 0.82160 | NA | NA |
| PHF6 | temozolomide | 0.8222578 | 0.9752458 | 0.82226 | NA | NA |
| NCOA2 | afatinib | 0.8224551 | 0.9752458 | 0.82246 | NA | NA |
| PIK3CA | pazopanib | 0.8224888 | 0.9752458 | 0.82249 | NA | NA |
| KMT2A | lapatinib | 0.8228845 | 0.9752458 | 0.82288 | NA | NA |
| ZRSR2 | crizotinib | 0.8231357 | 0.9752458 | 0.82314 | NA | NA |
| WHSC1 | crizotinib | 0.8232275 | 0.9752458 | 0.82323 | NA | NA |
| PRPF8 | afatinib | 0.8232418 | 0.9752458 | 0.82324 | NA | NA |
| ERBB4 | sunitinib | 0.8233327 | 0.9752458 | 0.82333 | NA | NA |
| FLT3 | palbociclib | 0.8239049 | 0.9752458 | 0.82390 | NA | NA |
| EGFR | bosutinib monohydrate | 0.8249647 | 0.9752458 | 0.82496 | NA | NA |
| BRCA1 | pazopanib | 0.8251732 | 0.9752458 | 0.82517 | NA | NA |
| TET2 | rucaparib | 0.8260219 | 0.9752458 | 0.82602 | NA | NA |
| MET | alectinib | 0.8262519 | 0.9752458 | 0.82625 | NA | NA |
| NOTCH1 | tretinoin | 0.8264829 | 0.9752458 | 0.82648 | NA | NA |
| G6PD | cabozantinib | 0.8264953 | 0.9752458 | 0.82650 | NA | NA |
| NCOA2 | sunitinib | 0.8265853 | 0.9752458 | 0.82659 | NA | NA |
| ERBB3 | sunitinib | 0.8272393 | 0.9752458 | 0.82724 | NA | NA |
| TSC1 | dabrafenib | 0.8273766 | 0.9752458 | 0.82738 | NA | NA |
| STAG2 | palbociclib | 0.8274365 | 0.9752458 | 0.82744 | NA | NA |
| CD79B | midostaurin | 0.8277512 | 0.9752458 | 0.82775 | NA | NA |
| PHF6 | trametinib | 0.8279218 | 0.9752458 | 0.82792 | NA | NA |
| VHL | ponatinib | 0.8280799 | 0.9752458 | 0.82808 | NA | NA |
| G6PD | midostaurin | 0.8281741 | 0.9752458 | 0.82817 | NA | NA |
| EML4 | dabrafenib | 0.8284492 | 0.9752458 | 0.82845 | NA | NA |
| NCOA2 | ponatinib | 0.8286775 | 0.9752458 | 0.82868 | NA | NA |
| FGFR1 | lapatinib | 0.8287747 | 0.9752458 | 0.82877 | NA | NA |
| KMT2A | pazopanib | 0.8299580 | 0.9762765 | 0.82996 | NA | NA |
| FLT3 | ruxolitinib | 0.8312495 | 0.9770529 | 0.83125 | NA | NA |
| MET | trametinib | 0.8326323 | 0.9770529 | 0.83263 | NA | NA |
| WHSC1 | midostaurin | 0.8326953 | 0.9770529 | 0.83270 | NA | NA |
| MAP2K1 | belinostat | 0.8327077 | 0.9770529 | 0.83271 | NA | NA |
| EML4 | pazopanib | 0.8328229 | 0.9770529 | 0.83282 | NA | NA |
| NCOA2 | cabozantinib | 0.8330328 | 0.9770529 | 0.83303 | NA | NA |
| FBXW7 | ruxolitinib | 0.8330920 | 0.9770529 | 0.83309 | NA | NA |
| BRCA1 | cabozantinib | 0.8333837 | 0.9770529 | 0.83338 | NA | NA |
| RIT1 | pazopanib | 0.8336905 | 0.9770529 | 0.83369 | NA | NA |
| GATA2 | midostaurin | 0.8338411 | 0.9770529 | 0.83384 | NA | NA |
| CXCR4 | trametinib | 0.8340020 | 0.9770529 | 0.83400 | NA | NA |
| CTCF | dasatinib | 0.8347924 | 0.9771109 | 0.83479 | NA | NA |
| MGMT | tretinoin | 0.8349168 | 0.9771109 | 0.83492 | NA | NA |
| CYP19A1 | rucaparib | 0.8350834 | 0.9771109 | 0.83508 | NA | NA |
| GNA11 | bosutinib monohydrate | 0.8354619 | 0.9771109 | 0.83546 | NA | NA |
| MET | midostaurin | 0.8355898 | 0.9771109 | 0.83559 | NA | NA |
| ETV6 | cabozantinib | 0.8369112 | 0.9782959 | 0.83691 | NA | NA |
| SRSF2 | pazopanib | 0.8374135 | 0.9785229 | 0.83741 | NA | NA |
| SMC1A | tretinoin | 0.8382380 | 0.9789018 | 0.83824 | NA | NA |
| CDK4 | alectinib | 0.8384108 | 0.9789018 | 0.83841 | NA | NA |
| CDK6 | docetaxel | 0.8387669 | 0.9789018 | 0.83877 | NA | NA |
| ASXL1 | imatinib | 0.8389707 | 0.9789018 | 0.83897 | NA | NA |
| GNAS | trametinib | 0.8402119 | 0.9794986 | 0.84021 | NA | NA |
| CALR | palbociclib | 0.8402810 | 0.9794986 | 0.84028 | NA | NA |
| CBL | alectinib | 0.8404483 | 0.9794986 | 0.84045 | NA | NA |
| FANCL | docetaxel | 0.8407316 | 0.9794986 | 0.84073 | NA | NA |
| MAP2K2 | temozolomide | 0.8411007 | 0.9794986 | 0.84110 | NA | NA |
| CBLB | crizotinib | 0.8413325 | 0.9794986 | 0.84133 | NA | NA |
| RET | rucaparib | 0.8423514 | 0.9801808 | 0.84235 | NA | NA |
| BRAF | cabozantinib | 0.8425783 | 0.9801808 | 0.84258 | NA | NA |
| GNB1 | docetaxel | 0.8431622 | 0.9801808 | 0.84316 | NA | NA |
| SETBP1 | vismodegib | 0.8431988 | 0.9801808 | 0.84320 | NA | NA |
| JAK1 | afatinib | 0.8434616 | 0.9801808 | 0.84346 | NA | NA |
| JAK3 | afatinib | 0.8440781 | 0.9805385 | 0.84408 | NA | NA |
| WT1 | ruxolitinib | 0.8454506 | 0.9809780 | 0.84545 | NA | NA |
| STAG2 | ponatinib | 0.8454770 | 0.9809780 | 0.84548 | NA | NA |
| EML4 | dasatinib | 0.8456669 | 0.9809780 | 0.84567 | NA | NA |
| EML4 | crizotinib | 0.8463945 | 0.9809780 | 0.84639 | NA | NA |
| UGT1A1 | rucaparib | 0.8467310 | 0.9809780 | 0.84673 | NA | NA |
| MAP2K1 | ponatinib | 0.8469335 | 0.9809780 | 0.84693 | NA | NA |
| ERBB2 | cabozantinib | 0.8477762 | 0.9809780 | 0.84778 | NA | NA |
| FGFR1 | ponatinib | 0.8480615 | 0.9809780 | 0.84806 | NA | NA |
| IDH1 | sunitinib | 0.8485350 | 0.9809780 | 0.84854 | NA | NA |
| MYCN | sunitinib | 0.8485350 | 0.9809780 | 0.84854 | NA | NA |
| DDIT3 | vismodegib | 0.8486410 | 0.9809780 | 0.84864 | NA | NA |
| PAX8 | temozolomide | 0.8489663 | 0.9809780 | 0.84897 | NA | NA |
| SF3B1 | ponatinib | 0.8491288 | 0.9809780 | 0.84913 | NA | NA |
| EZH2 | dabrafenib | 0.8492920 | 0.9809780 | 0.84929 | NA | NA |
| DNMT3A | gefitinib | 0.8493836 | 0.9809780 | 0.84938 | NA | NA |
| STAG2 | cabozantinib | 0.8502250 | 0.9809780 | 0.85023 | NA | NA |
| TPMT | pazopanib | 0.8511938 | 0.9809780 | 0.85119 | NA | NA |
| PRPF8 | erlotinib | 0.8511983 | 0.9809780 | 0.85120 | NA | NA |
| KRAS | crizotinib | 0.8512775 | 0.9809780 | 0.85128 | NA | NA |
| MET | cabozantinib | 0.8512783 | 0.9809780 | 0.85128 | NA | NA |
| CRLF2 | vismodegib | 0.8514764 | 0.9809780 | 0.85148 | NA | NA |
| GATA3 | rucaparib | 0.8515819 | 0.9809780 | 0.85158 | NA | NA |
| JAK2 | imatinib | 0.8521878 | 0.9809780 | 0.85219 | NA | NA |
| JAK2 | ruxolitinib | 0.8523436 | 0.9809780 | 0.85234 | NA | NA |
| FGFR3 | bosutinib monohydrate | 0.8529747 | 0.9809780 | 0.85297 | NA | NA |
| GNAS | gefitinib | 0.8530306 | 0.9809780 | 0.85303 | NA | NA |
| CSF3R | bosutinib monohydrate | 0.8534255 | 0.9809780 | 0.85343 | NA | NA |
| BTK | dabrafenib | 0.8535378 | 0.9809780 | 0.85354 | NA | NA |
| UGT1A1 | docetaxel | 0.8542969 | 0.9809780 | 0.85430 | NA | NA |
| STAT3 | palbociclib | 0.8543064 | 0.9809780 | 0.85431 | NA | NA |
| MET | dasatinib | 0.8543593 | 0.9809780 | 0.85436 | NA | NA |
| CXCR4 | crizotinib | 0.8549228 | 0.9809780 | 0.85492 | NA | NA |
| JAK1 | nilotinib | 0.8549572 | 0.9809780 | 0.85496 | NA | NA |
| WT1 | nilotinib | 0.8552599 | 0.9809780 | 0.85526 | NA | NA |
| MYD88 | ponatinib | 0.8552763 | 0.9809780 | 0.85528 | NA | NA |
| FGFR2 | vismodegib | 0.8556611 | 0.9809780 | 0.85566 | NA | NA |
| ERBB4 | ponatinib | 0.8558847 | 0.9809780 | 0.85588 | NA | NA |
| CRLF2 | gefitinib | 0.8566401 | 0.9814103 | 0.85664 | NA | NA |
| EML4 | gefitinib | 0.8568799 | 0.9814103 | 0.85688 | NA | NA |
| FLCN | afatinib | 0.8573994 | 0.9815915 | 0.85740 | NA | NA |
| CTNNB1 | rucaparib | 0.8579792 | 0.9815915 | 0.85798 | NA | NA |
| BTK | nilotinib | 0.8582165 | 0.9815915 | 0.85822 | NA | NA |
| CSF3R | lapatinib | 0.8590618 | 0.9815915 | 0.85906 | NA | NA |
| SMO | gefitinib | 0.8593636 | 0.9815915 | 0.85936 | NA | NA |
| RUNX1 | afatinib | 0.8597949 | 0.9815915 | 0.85979 | NA | NA |
| CRLF2 | afatinib | 0.8603484 | 0.9815915 | 0.86035 | NA | NA |
| GNAQ | afatinib | 0.8603484 | 0.9815915 | 0.86035 | NA | NA |
| DPYD | erlotinib | 0.8604995 | 0.9815915 | 0.86050 | NA | NA |
| GNB1 | erlotinib | 0.8604995 | 0.9815915 | 0.86050 | NA | NA |
| PRPF40B | dabrafenib | 0.8607282 | 0.9815915 | 0.86073 | NA | NA |
| PRPF40B | tretinoin | 0.8614099 | 0.9815915 | 0.86141 | NA | NA |
| PAX5 | rucaparib | 0.8616629 | 0.9815915 | 0.86166 | NA | NA |
| IDH1 | cabozantinib | 0.8618554 | 0.9815915 | 0.86186 | NA | NA |
| CD79B | crizotinib | 0.8619832 | 0.9815915 | 0.86198 | NA | NA |
| GNAQ | crizotinib | 0.8619832 | 0.9815915 | 0.86198 | NA | NA |
| IL7R | dasatinib | 0.8625869 | 0.9816246 | 0.86259 | NA | NA |
| ROS1 | palbociclib | 0.8627523 | 0.9816246 | 0.86275 | NA | NA |
| CRLF2 | sunitinib | 0.8629395 | 0.9816246 | 0.86294 | NA | NA |
| GNB1 | vismodegib | 0.8642884 | 0.9823372 | 0.86429 | NA | NA |
| PRPF40B | alectinib | 0.8649658 | 0.9823372 | 0.86497 | NA | NA |
| ERBB4 | erlotinib | 0.8652272 | 0.9823372 | 0.86523 | NA | NA |
| RIT1 | trametinib | 0.8654388 | 0.9823372 | 0.86544 | NA | NA |
| NPM1 | afatinib | 0.8655570 | 0.9823372 | 0.86556 | NA | NA |
| UGT1A1 | vismodegib | 0.8657073 | 0.9823372 | 0.86571 | NA | NA |
| NCOA2 | docetaxel | 0.8662319 | 0.9823372 | 0.86623 | NA | NA |
| PHF6 | belinostat | 0.8666835 | 0.9823372 | 0.86668 | NA | NA |
| PTPN11 | gefitinib | 0.8668680 | 0.9823372 | 0.86687 | NA | NA |
| RIT1 | dabrafenib | 0.8669500 | 0.9823372 | 0.86695 | NA | NA |
| SF3B1 | crizotinib | 0.8672340 | 0.9823372 | 0.86723 | NA | NA |
| NPM1 | trametinib | 0.8672776 | 0.9823372 | 0.86728 | NA | NA |
| SETD2 | temozolomide | 0.8680092 | 0.9824100 | 0.86801 | NA | NA |
| G6PD | dasatinib | 0.8682306 | 0.9824100 | 0.86823 | NA | NA |
| KIT | crizotinib | 0.8686498 | 0.9824100 | 0.86865 | NA | NA |
| U2AF1 | lapatinib | 0.8687945 | 0.9824100 | 0.86879 | NA | NA |
| SMO | belinostat | 0.8688884 | 0.9824100 | 0.86889 | NA | NA |
| ESR1 | ponatinib | 0.8695576 | 0.9824849 | 0.86956 | NA | NA |
| FLT3 | bosutinib monohydrate | 0.8695733 | 0.9824849 | 0.86957 | NA | NA |
| PDCD1 | ponatinib | 0.8703157 | 0.9829740 | 0.87032 | NA | NA |
| GATA1 | docetaxel | 0.8709152 | 0.9833014 | 0.87092 | NA | NA |
| GATA3 | nilotinib | 0.8715965 | 0.9834739 | 0.87160 | NA | NA |
| PDCD1 | gefitinib | 0.8718376 | 0.9834739 | 0.87184 | NA | NA |
| KMT2A | ponatinib | 0.8723076 | 0.9834739 | 0.87231 | NA | NA |
| CXCR4 | alectinib | 0.8726340 | 0.9834739 | 0.87263 | NA | NA |
| SRSF2 | temozolomide | 0.8729244 | 0.9834739 | 0.87292 | NA | NA |
| CDC73 | alectinib | 0.8729260 | 0.9834739 | 0.87293 | NA | NA |
| DNMT3A | lapatinib | 0.8744953 | 0.9848926 | 0.87450 | NA | NA |
| FGFR3 | tretinoin | 0.8758961 | 0.9861205 | 0.87590 | NA | NA |
| CDK4 | imatinib | 0.8774107 | 0.9874757 | 0.87741 | NA | NA |
| NOTCH1 | nilotinib | 0.8779959 | 0.9877843 | 0.87800 | NA | NA |
| STAG2 | lapatinib | 0.8799391 | 0.9884322 | 0.87994 | NA | NA |
| CXCR4 | erlotinib | 0.8802653 | 0.9884322 | 0.88027 | NA | NA |
| ERBB3 | vismodegib | 0.8804120 | 0.9884322 | 0.88041 | NA | NA |
| WHSC1 | afatinib | 0.8804758 | 0.9884322 | 0.88048 | NA | NA |
| RUNX1 | imatinib | 0.8807874 | 0.9884322 | 0.88079 | NA | NA |
| TPMT | ponatinib | 0.8811769 | 0.9884322 | 0.88118 | NA | NA |
| AR | afatinib | 0.8812495 | 0.9884322 | 0.88125 | NA | NA |
| PAX5 | dabrafenib | 0.8814339 | 0.9884322 | 0.88143 | NA | NA |
| PIK3CA | bosutinib monohydrate | 0.8814447 | 0.9884322 | 0.88144 | NA | NA |
| ERBB4 | docetaxel | 0.8816840 | 0.9884322 | 0.88168 | NA | NA |
| AKT3 | belinostat | 0.8831307 | 0.9889058 | 0.88313 | NA | NA |
| MAP2K1 | midostaurin | 0.8831837 | 0.9889058 | 0.88318 | NA | NA |
| MYCN | dabrafenib | 0.8835841 | 0.9889058 | 0.88358 | NA | NA |
| FGFR1 | tretinoin | 0.8836154 | 0.9889058 | 0.88362 | NA | NA |
| WT1 | lapatinib | 0.8836758 | 0.9889058 | 0.88368 | NA | NA |
| AR | palbociclib | 0.8839747 | 0.9889058 | 0.88397 | NA | NA |
| JAK2 | midostaurin | 0.8847197 | 0.9893907 | 0.88472 | NA | NA |
| DNAJB1 | docetaxel | 0.8861532 | 0.9904803 | 0.88615 | NA | NA |
| FGFR1 | cabozantinib | 0.8867029 | 0.9904803 | 0.88670 | NA | NA |
| EML4 | erlotinib | 0.8868224 | 0.9904803 | 0.88682 | NA | NA |
| BRCA2 | ruxolitinib | 0.8869414 | 0.9904803 | 0.88694 | NA | NA |
| TET2 | erlotinib | 0.8873786 | 0.9906202 | 0.88738 | NA | NA |
| JAK1 | lapatinib | 0.8879653 | 0.9909269 | 0.88797 | NA | NA |
| PHF6 | nilotinib | 0.8886369 | 0.9912900 | 0.88864 | NA | NA |
| ATM | bosutinib monohydrate | 0.8890563 | 0.9912900 | 0.88906 | NA | NA |
| MYD88 | bosutinib monohydrate | 0.8892270 | 0.9912900 | 0.88923 | NA | NA |
| PIGA | bosutinib monohydrate | 0.8899516 | 0.9917496 | 0.88995 | NA | NA |
| JAK2 | pazopanib | 0.8907594 | 0.9918063 | 0.89076 | NA | NA |
| CTLA4 | palbociclib | 0.8909703 | 0.9918063 | 0.89097 | NA | NA |
| BTK | lapatinib | 0.8911322 | 0.9918063 | 0.89113 | NA | NA |
| SMO | vismodegib | 0.8914996 | 0.9918063 | 0.89150 | NA | NA |
| SETD2 | gefitinib | 0.8920610 | 0.9918063 | 0.89206 | NA | NA |
| FGFR3 | alectinib | 0.8924433 | 0.9918063 | 0.89244 | NA | NA |
| FGFR2 | dasatinib | 0.8929128 | 0.9918063 | 0.89291 | NA | NA |
| SETD2 | ruxolitinib | 0.8932673 | 0.9918063 | 0.89327 | NA | NA |
| STAT3 | trametinib | 0.8932780 | 0.9918063 | 0.89328 | NA | NA |
| FGFR2 | sunitinib | 0.8937255 | 0.9918063 | 0.89373 | NA | NA |
| CRLF2 | midostaurin | 0.8940790 | 0.9918063 | 0.89408 | NA | NA |
| IDH1 | afatinib | 0.8943509 | 0.9918063 | 0.89435 | NA | NA |
| MYCN | bosutinib monohydrate | 0.8946713 | 0.9918063 | 0.89467 | NA | NA |
| IKZF1 | afatinib | 0.8947795 | 0.9918063 | 0.89478 | NA | NA |
| PRPF40B | palbociclib | 0.8948596 | 0.9918063 | 0.89486 | NA | NA |
| CDK4 | ruxolitinib | 0.8949990 | 0.9918063 | 0.89500 | NA | NA |
| BRCA2 | cabozantinib | 0.8957636 | 0.9919816 | 0.89576 | NA | NA |
| BCOR | alectinib | 0.8960633 | 0.9919816 | 0.89606 | NA | NA |
| EML4 | belinostat | 0.8965070 | 0.9919816 | 0.89651 | NA | NA |
| ROS1 | ruxolitinib | 0.8966205 | 0.9919816 | 0.89662 | NA | NA |
| PML | trametinib | 0.8969530 | 0.9919816 | 0.89695 | NA | NA |
| GNAS | docetaxel | 0.8970312 | 0.9919816 | 0.89703 | NA | NA |
| MPL | pazopanib | 0.8975234 | 0.9921804 | 0.89752 | NA | NA |
| RPL10 | temozolomide | 0.8989536 | 0.9921877 | 0.89895 | NA | NA |
| MGMT | dasatinib | 0.8989855 | 0.9921877 | 0.89899 | NA | NA |
| SSX1 | trametinib | 0.8990463 | 0.9921877 | 0.89905 | NA | NA |
| AR | bosutinib monohydrate | 0.8991314 | 0.9921877 | 0.89913 | NA | NA |
| PTEN | lapatinib | 0.8993258 | 0.9921877 | 0.89933 | NA | NA |
| CEBPA | ponatinib | 0.8994044 | 0.9921877 | 0.89940 | NA | NA |
| CDK4 | nilotinib | 0.8998193 | 0.9922569 | 0.89982 | NA | NA |
| SMC1A | palbociclib | 0.9001829 | 0.9922569 | 0.90018 | NA | NA |
| GATA3 | dabrafenib | 0.9004044 | 0.9922569 | 0.90040 | NA | NA |
| ALK | bosutinib monohydrate | 0.9008561 | 0.9923487 | 0.90086 | NA | NA |
| BRAF | afatinib | 0.9011510 | 0.9923487 | 0.90115 | NA | NA |
| NT5C2 | pazopanib | 0.9014251 | 0.9923487 | 0.90143 | NA | NA |
| AKT2 | imatinib | 0.9023418 | 0.9930137 | 0.90234 | NA | NA |
| SETD2 | erlotinib | 0.9034192 | 0.9938550 | 0.90342 | NA | NA |
| ROS1 | crizotinib | 0.9055984 | 0.9956992 | 0.90560 | NA | NA |
| CRLF2 | alectinib | 0.9059455 | 0.9956992 | 0.90595 | NA | NA |
| TSC1 | belinostat | 0.9061702 | 0.9956992 | 0.90617 | NA | NA |
| GATA2 | nilotinib | 0.9063496 | 0.9956992 | 0.90635 | NA | NA |
| ERBB3 | docetaxel | 0.9076995 | 0.9964206 | 0.90770 | NA | NA |
| NOTCH1 | pazopanib | 0.9077883 | 0.9964206 | 0.90779 | NA | NA |
| WT1 | bosutinib monohydrate | 0.9087099 | 0.9964206 | 0.90871 | NA | NA |
| CDKN2A | lapatinib | 0.9091620 | 0.9964206 | 0.90916 | NA | NA |
| AKT1 | temozolomide | 0.9094399 | 0.9964206 | 0.90944 | NA | NA |
| U2AF1 | vismodegib | 0.9095190 | 0.9964206 | 0.90952 | NA | NA |
| ASXL1 | vismodegib | 0.9095642 | 0.9964206 | 0.90956 | NA | NA |
| CDKN2A | crizotinib | 0.9099113 | 0.9964206 | 0.90991 | NA | NA |
| GATA1 | ponatinib | 0.9103985 | 0.9964206 | 0.91040 | NA | NA |
| SMC3 | ponatinib | 0.9106175 | 0.9964206 | 0.91062 | NA | NA |
| CYP19A1 | dabrafenib | 0.9107211 | 0.9964206 | 0.91072 | NA | NA |
| EML4 | lapatinib | 0.9110932 | 0.9964206 | 0.91109 | NA | NA |
| CTLA4 | rucaparib | 0.9111547 | 0.9964206 | 0.91115 | NA | NA |
| PRPF8 | alectinib | 0.9120043 | 0.9964206 | 0.91200 | NA | NA |
| BCOR | afatinib | 0.9121893 | 0.9964206 | 0.91219 | NA | NA |
| CREBBP | cabozantinib | 0.9124382 | 0.9964206 | 0.91244 | NA | NA |
| ESR1 | erlotinib | 0.9133687 | 0.9964206 | 0.91337 | NA | NA |
| JAK1 | crizotinib | 0.9136622 | 0.9964206 | 0.91366 | NA | NA |
| BRCA1 | lapatinib | 0.9142372 | 0.9964206 | 0.91424 | NA | NA |
| EGFR | cabozantinib | 0.9149328 | 0.9964206 | 0.91493 | NA | NA |
| BRCA2 | sunitinib | 0.9151190 | 0.9964206 | 0.91512 | NA | NA |
| FGFR1 | dabrafenib | 0.9151888 | 0.9964206 | 0.91519 | NA | NA |
| NOTCH2 | imatinib | 0.9152305 | 0.9964206 | 0.91523 | NA | NA |
| CD79B | ruxolitinib | 0.9154477 | 0.9964206 | 0.91545 | NA | NA |
| TSC1 | gefitinib | 0.9156569 | 0.9964206 | 0.91566 | NA | NA |
| ROS1 | imatinib | 0.9157097 | 0.9964206 | 0.91571 | NA | NA |
| ERBB2 | ponatinib | 0.9158815 | 0.9964206 | 0.91588 | NA | NA |
| NT5C2 | afatinib | 0.9160346 | 0.9964206 | 0.91603 | NA | NA |
| BRAF | dasatinib | 0.9161548 | 0.9964206 | 0.91615 | NA | NA |
| KMT2A | temozolomide | 0.9165748 | 0.9964206 | 0.91657 | NA | NA |
| BRCA2 | dabrafenib | 0.9168207 | 0.9964206 | 0.91682 | NA | NA |
| CBLB | erlotinib | 0.9170458 | 0.9964206 | 0.91705 | NA | NA |
| G6PD | temozolomide | 0.9184100 | 0.9975617 | 0.91841 | NA | NA |
| PRPF40B | docetaxel | 0.9187358 | 0.9975743 | 0.91874 | NA | NA |
| TP53 | crizotinib | 0.9190956 | 0.9976239 | 0.91910 | NA | NA |
| IL7R | docetaxel | 0.9196203 | 0.9978525 | 0.91962 | NA | NA |
| JAK2 | lapatinib | 0.9210478 | 0.9978589 | 0.92105 | NA | NA |
| PIK3CA | ponatinib | 0.9215126 | 0.9978589 | 0.92151 | NA | NA |
| NPM1 | sunitinib | 0.9216497 | 0.9978589 | 0.92165 | NA | NA |
| PRPF8 | ponatinib | 0.9216621 | 0.9978589 | 0.92166 | NA | NA |
| EED | palbociclib | 0.9217317 | 0.9978589 | 0.92173 | NA | NA |
| JAK1 | docetaxel | 0.9217329 | 0.9978589 | 0.92173 | NA | NA |
| EGFR | erlotinib | 0.9218958 | 0.9978589 | 0.92190 | NA | NA |
| ATM | belinostat | 0.9231828 | 0.9978589 | 0.92318 | NA | NA |
| SETBP1 | imatinib | 0.9231968 | 0.9978589 | 0.92320 | NA | NA |
| PRPF8 | lapatinib | 0.9234249 | 0.9978589 | 0.92342 | NA | NA |
| CBL | cabozantinib | 0.9234314 | 0.9978589 | 0.92343 | NA | NA |
| NOTCH1 | ponatinib | 0.9235323 | 0.9978589 | 0.92353 | NA | NA |
| CREBBP | vismodegib | 0.9238700 | 0.9978589 | 0.92387 | NA | NA |
| SH2B3 | alectinib | 0.9243076 | 0.9978589 | 0.92431 | NA | NA |
| ROS1 | lapatinib | 0.9246091 | 0.9978589 | 0.92461 | NA | NA |
| PDGFRA | ruxolitinib | 0.9248089 | 0.9978589 | 0.92481 | NA | NA |
| HRAS | bosutinib monohydrate | 0.9249674 | 0.9978589 | 0.92497 | NA | NA |
| KIT | ponatinib | 0.9257639 | 0.9978685 | 0.92576 | NA | NA |
| SF3B1 | temozolomide | 0.9259576 | 0.9978685 | 0.92596 | NA | NA |
| CTNNB1 | belinostat | 0.9260261 | 0.9978685 | 0.92603 | NA | NA |
| UGT1A1 | cabozantinib | 0.9262331 | 0.9978685 | 0.92623 | NA | NA |
| PTCH1 | erlotinib | 0.9275623 | 0.9980324 | 0.92756 | NA | NA |
| CALR | belinostat | 0.9275787 | 0.9980324 | 0.92758 | NA | NA |
| CTCF | pazopanib | 0.9276294 | 0.9980324 | 0.92763 | NA | NA |
| AR | pazopanib | 0.9277609 | 0.9980324 | 0.92776 | NA | NA |
| MYD88 | gefitinib | 0.9283678 | 0.9980324 | 0.92837 | NA | NA |
| GNAQ | ponatinib | 0.9286811 | 0.9980324 | 0.92868 | NA | NA |
| FBXW7 | belinostat | 0.9290017 | 0.9980324 | 0.92900 | NA | NA |
| CREBBP | alectinib | 0.9297312 | 0.9980324 | 0.92973 | NA | NA |
| TSC1 | afatinib | 0.9300086 | 0.9980324 | 0.93001 | NA | NA |
| KIT | belinostat | 0.9303304 | 0.9980324 | 0.93033 | NA | NA |
| EML4 | temozolomide | 0.9305234 | 0.9980324 | 0.93052 | NA | NA |
| RET | erlotinib | 0.9307227 | 0.9980324 | 0.93072 | NA | NA |
| MAP2K2 | ponatinib | 0.9308325 | 0.9980324 | 0.93083 | NA | NA |
| EML4 | ruxolitinib | 0.9311316 | 0.9980324 | 0.93113 | NA | NA |
| PTEN | imatinib | 0.9311434 | 0.9980324 | 0.93114 | NA | NA |
| MYCN | alectinib | 0.9314131 | 0.9980324 | 0.93141 | NA | NA |
| MYD88 | lapatinib | 0.9323054 | 0.9983599 | 0.93231 | NA | NA |
| BTK | temozolomide | 0.9330073 | 0.9983599 | 0.93301 | NA | NA |
| SF3B1 | cabozantinib | 0.9332356 | 0.9983599 | 0.93324 | NA | NA |
| IDH1 | crizotinib | 0.9332905 | 0.9983599 | 0.93329 | NA | NA |
| MYCN | crizotinib | 0.9332905 | 0.9983599 | 0.93329 | NA | NA |
| ATM | cabozantinib | 0.9341291 | 0.9983602 | 0.93413 | NA | NA |
| STAT3 | pazopanib | 0.9342701 | 0.9983602 | 0.93427 | NA | NA |
| IDH1 | alectinib | 0.9344033 | 0.9983602 | 0.93440 | NA | NA |
| SETBP1 | rucaparib | 0.9349068 | 0.9983602 | 0.93491 | NA | NA |
| CALR | bosutinib monohydrate | 0.9357151 | 0.9983602 | 0.93572 | NA | NA |
| NOTCH2 | trametinib | 0.9359551 | 0.9983602 | 0.93596 | NA | NA |
| PAX5 | belinostat | 0.9366113 | 0.9983602 | 0.93661 | NA | NA |
| CDK6 | belinostat | 0.9369710 | 0.9983602 | 0.93697 | NA | NA |
| CALR | alectinib | 0.9372021 | 0.9983602 | 0.93720 | NA | NA |
| MDM2 | belinostat | 0.9372150 | 0.9983602 | 0.93721 | NA | NA |
| VHL | trametinib | 0.9375075 | 0.9983602 | 0.93751 | NA | NA |
| AKT3 | vismodegib | 0.9378898 | 0.9983602 | 0.93789 | NA | NA |
| PDCD1 | tretinoin | 0.9379623 | 0.9983602 | 0.93796 | NA | NA |
| BTK | crizotinib | 0.9381895 | 0.9983602 | 0.93819 | NA | NA |
| PAX8 | imatinib | 0.9384184 | 0.9983602 | 0.93842 | NA | NA |
| IL7R | lapatinib | 0.9384466 | 0.9983602 | 0.93845 | NA | NA |
| NCOA2 | alectinib | 0.9388572 | 0.9983602 | 0.93886 | NA | NA |
| GATA2 | dabrafenib | 0.9389490 | 0.9983602 | 0.93895 | NA | NA |
| FLCN | rucaparib | 0.9396675 | 0.9983602 | 0.93967 | NA | NA |
| MGMT | vismodegib | 0.9400649 | 0.9983602 | 0.94006 | NA | NA |
| FBXW7 | trametinib | 0.9408952 | 0.9983602 | 0.94090 | NA | NA |
| SSX1 | vismodegib | 0.9409047 | 0.9983602 | 0.94090 | NA | NA |
| RPL10 | belinostat | 0.9410297 | 0.9983602 | 0.94103 | NA | NA |
| STAG2 | dasatinib | 0.9411192 | 0.9983602 | 0.94112 | NA | NA |
| CDK4 | bosutinib monohydrate | 0.9416541 | 0.9983602 | 0.94165 | NA | NA |
| BRCA2 | trametinib | 0.9421624 | 0.9983602 | 0.94216 | NA | NA |
| ASXL1 | sunitinib | 0.9421871 | 0.9983602 | 0.94219 | NA | NA |
| FBXW7 | bosutinib monohydrate | 0.9426717 | 0.9983602 | 0.94267 | NA | NA |
| CSF3R | belinostat | 0.9429053 | 0.9983602 | 0.94291 | NA | NA |
| PIGA | dabrafenib | 0.9436553 | 0.9983602 | 0.94366 | NA | NA |
| IDH2 | alectinib | 0.9437117 | 0.9983602 | 0.94371 | NA | NA |
| FANCL | temozolomide | 0.9438077 | 0.9983602 | 0.94381 | NA | NA |
| IDH2 | palbociclib | 0.9443484 | 0.9983602 | 0.94435 | NA | NA |
| CSF3R | alectinib | 0.9447105 | 0.9983602 | 0.94471 | NA | NA |
| EGFR | vismodegib | 0.9448114 | 0.9983602 | 0.94481 | NA | NA |
| ERBB4 | rucaparib | 0.9452339 | 0.9983602 | 0.94523 | NA | NA |
| TP53 | bosutinib monohydrate | 0.9456282 | 0.9983602 | 0.94563 | NA | NA |
| RAD21 | belinostat | 0.9463328 | 0.9983602 | 0.94633 | NA | NA |
| CXCR4 | imatinib | 0.9466483 | 0.9983602 | 0.94665 | NA | NA |
| MPL | imatinib | 0.9466483 | 0.9983602 | 0.94665 | NA | NA |
| XPO1 | midostaurin | 0.9469456 | 0.9983602 | 0.94695 | NA | NA |
| IDH2 | midostaurin | 0.9477169 | 0.9983602 | 0.94772 | NA | NA |
| RIT1 | midostaurin | 0.9477169 | 0.9983602 | 0.94772 | NA | NA |
| CRLF2 | rucaparib | 0.9477501 | 0.9983602 | 0.94775 | NA | NA |
| ABL1 | vismodegib | 0.9494533 | 0.9983602 | 0.94945 | NA | NA |
| CBLB | sunitinib | 0.9503016 | 0.9983602 | 0.95030 | NA | NA |
| ESR1 | afatinib | 0.9503087 | 0.9983602 | 0.95031 | NA | NA |
| CSF3R | temozolomide | 0.9503618 | 0.9983602 | 0.95036 | NA | NA |
| SETD2 | docetaxel | 0.9506315 | 0.9983602 | 0.95063 | NA | NA |
| SRSF2 | alectinib | 0.9507839 | 0.9983602 | 0.95078 | NA | NA |
| PRPF8 | ruxolitinib | 0.9509706 | 0.9983602 | 0.95097 | NA | NA |
| BCOR | lapatinib | 0.9510755 | 0.9983602 | 0.95108 | NA | NA |
| FGFR2 | afatinib | 0.9511520 | 0.9983602 | 0.95115 | NA | NA |
| ROS1 | dasatinib | 0.9512458 | 0.9983602 | 0.95125 | NA | NA |
| AKT2 | dasatinib | 0.9512631 | 0.9983602 | 0.95126 | NA | NA |
| UGT1A1 | ruxolitinib | 0.9514154 | 0.9983602 | 0.95142 | NA | NA |
| ETV6 | belinostat | 0.9514347 | 0.9983602 | 0.95143 | NA | NA |
| FANCL | belinostat | 0.9517795 | 0.9983602 | 0.95178 | NA | NA |
| PML | afatinib | 0.9518372 | 0.9983602 | 0.95184 | NA | NA |
| BRCA1 | temozolomide | 0.9526259 | 0.9988577 | 0.95263 | NA | NA |
| ETV6 | erlotinib | 0.9532871 | 0.9989432 | 0.95329 | NA | NA |
| SMO | trametinib | 0.9533365 | 0.9989432 | 0.95334 | NA | NA |
| MAP2K2 | tretinoin | 0.9548035 | 0.9990974 | 0.95480 | NA | NA |
| CRLF2 | ponatinib | 0.9548438 | 0.9990974 | 0.95484 | NA | NA |
| NCOA2 | bosutinib monohydrate | 0.9552949 | 0.9990974 | 0.95529 | NA | NA |
| CD79B | vismodegib | 0.9553598 | 0.9990974 | 0.95536 | NA | NA |
| PRPF8 | trametinib | 0.9559535 | 0.9990974 | 0.95595 | NA | NA |
| ALK | ponatinib | 0.9561548 | 0.9990974 | 0.95615 | NA | NA |
| SSX1 | nilotinib | 0.9563025 | 0.9990974 | 0.95630 | NA | NA |
| RET | midostaurin | 0.9563247 | 0.9990974 | 0.95632 | NA | NA |
| IKZF1 | rucaparib | 0.9570156 | 0.9990974 | 0.95702 | NA | NA |
| GATA1 | tretinoin | 0.9577014 | 0.9990974 | 0.95770 | NA | NA |
| BRAF | lapatinib | 0.9579143 | 0.9990974 | 0.95791 | NA | NA |
| SMC1A | belinostat | 0.9581409 | 0.9990974 | 0.95814 | NA | NA |
| RET | pazopanib | 0.9581510 | 0.9990974 | 0.95815 | NA | NA |
| SETD2 | crizotinib | 0.9583372 | 0.9990974 | 0.95834 | NA | NA |
| BCORL1 | rucaparib | 0.9589124 | 0.9990974 | 0.95891 | NA | NA |
| PAX5 | palbociclib | 0.9597535 | 0.9990974 | 0.95975 | NA | NA |
| TET2 | sunitinib | 0.9597590 | 0.9990974 | 0.95976 | NA | NA |
| CXCR4 | pazopanib | 0.9598696 | 0.9990974 | 0.95987 | NA | NA |
| PDGFRA | dasatinib | 0.9608776 | 0.9990974 | 0.96088 | NA | NA |
| NRAS | bosutinib monohydrate | 0.9617340 | 0.9990974 | 0.96173 | NA | NA |
| SMC1A | ponatinib | 0.9617697 | 0.9990974 | 0.96177 | NA | NA |
| GNAQ | cabozantinib | 0.9622409 | 0.9990974 | 0.96224 | NA | NA |
| ASXL1 | nilotinib | 0.9628343 | 0.9990974 | 0.96283 | NA | NA |
| MPL | ruxolitinib | 0.9628412 | 0.9990974 | 0.96284 | NA | NA |
| BTK | belinostat | 0.9628687 | 0.9990974 | 0.96287 | NA | NA |
| XPO1 | lapatinib | 0.9630445 | 0.9990974 | 0.96304 | NA | NA |
| FBXW7 | palbociclib | 0.9637857 | 0.9990974 | 0.96379 | NA | NA |
| ALK | imatinib | 0.9639389 | 0.9990974 | 0.96394 | NA | NA |
| FLCN | temozolomide | 0.9645329 | 0.9990974 | 0.96453 | NA | NA |
| CRLF2 | ruxolitinib | 0.9649859 | 0.9990974 | 0.96499 | NA | NA |
| SF1 | rucaparib | 0.9651374 | 0.9990974 | 0.96514 | NA | NA |
| GATA3 | erlotinib | 0.9653874 | 0.9990974 | 0.96539 | NA | NA |
| SF1 | vismodegib | 0.9658373 | 0.9990974 | 0.96584 | NA | NA |
| SH2B3 | gefitinib | 0.9659820 | 0.9990974 | 0.96598 | NA | NA |
| NT5C2 | lapatinib | 0.9661181 | 0.9990974 | 0.96612 | NA | NA |
| GNAS | belinostat | 0.9662777 | 0.9990974 | 0.96628 | NA | NA |
| BCORL1 | vismodegib | 0.9665371 | 0.9990974 | 0.96654 | NA | NA |
| NCOA2 | gefitinib | 0.9667617 | 0.9990974 | 0.96676 | NA | NA |
| BCOR | ponatinib | 0.9670462 | 0.9990974 | 0.96705 | NA | NA |
| CRLF2 | imatinib | 0.9673747 | 0.9990974 | 0.96737 | NA | NA |
| DPYD | nilotinib | 0.9678380 | 0.9990974 | 0.96784 | NA | NA |
| G6PD | lapatinib | 0.9681165 | 0.9990974 | 0.96812 | NA | NA |
| AR | dabrafenib | 0.9681760 | 0.9990974 | 0.96818 | NA | NA |
| IDH2 | dabrafenib | 0.9684328 | 0.9990974 | 0.96843 | NA | NA |
| PAX5 | trametinib | 0.9686829 | 0.9990974 | 0.96868 | NA | NA |
| KIT | alectinib | 0.9692528 | 0.9990974 | 0.96925 | NA | NA |
| AKT1 | docetaxel | 0.9695144 | 0.9990974 | 0.96951 | NA | NA |
| AKT2 | ruxolitinib | 0.9698154 | 0.9990974 | 0.96982 | NA | NA |
| RUNX1 | bosutinib monohydrate | 0.9702483 | 0.9990974 | 0.97025 | NA | NA |
| SMC3 | docetaxel | 0.9711363 | 0.9990974 | 0.97114 | NA | NA |
| AKT2 | trametinib | 0.9713673 | 0.9990974 | 0.97137 | NA | NA |
| MDM2 | erlotinib | 0.9714442 | 0.9990974 | 0.97144 | NA | NA |
| DNMT3A | belinostat | 0.9723117 | 0.9990974 | 0.97231 | NA | NA |
| CYP19A1 | vismodegib | 0.9723531 | 0.9990974 | 0.97235 | NA | NA |
| MDM2 | dasatinib | 0.9723856 | 0.9990974 | 0.97239 | NA | NA |
| GATA2 | ruxolitinib | 0.9725671 | 0.9990974 | 0.97257 | NA | NA |
| PDCD1 | rucaparib | 0.9729859 | 0.9990974 | 0.97299 | NA | NA |
| FANCL | dabrafenib | 0.9732873 | 0.9990974 | 0.97329 | NA | NA |
| BRCA2 | vismodegib | 0.9733078 | 0.9990974 | 0.97331 | NA | NA |
| SMC3 | dabrafenib | 0.9734466 | 0.9990974 | 0.97345 | NA | NA |
| AR | ponatinib | 0.9737798 | 0.9990974 | 0.97378 | NA | NA |
| PML | lapatinib | 0.9738117 | 0.9990974 | 0.97381 | NA | NA |
| VHL | cabozantinib | 0.9746401 | 0.9990974 | 0.97464 | NA | NA |
| AKT2 | dabrafenib | 0.9755082 | 0.9990974 | 0.97551 | NA | NA |
| WHSC1 | alectinib | 0.9757368 | 0.9990974 | 0.97574 | NA | NA |
| PIGA | vismodegib | 0.9761297 | 0.9990974 | 0.97613 | NA | NA |
| ERBB4 | pazopanib | 0.9762228 | 0.9990974 | 0.97622 | NA | NA |
| U2AF1 | belinostat | 0.9762326 | 0.9990974 | 0.97623 | NA | NA |
| NRAS | alectinib | 0.9762797 | 0.9990974 | 0.97628 | NA | NA |
| BCOR | palbociclib | 0.9763682 | 0.9990974 | 0.97637 | NA | NA |
| PAX5 | ponatinib | 0.9765095 | 0.9990974 | 0.97651 | NA | NA |
| CRLF2 | bosutinib monohydrate | 0.9769377 | 0.9990974 | 0.97694 | NA | NA |
| ATM | ruxolitinib | 0.9769582 | 0.9990974 | 0.97696 | NA | NA |
| CBLB | afatinib | 0.9770926 | 0.9990974 | 0.97709 | NA | NA |
| FLT3 | vismodegib | 0.9773105 | 0.9990974 | 0.97731 | NA | NA |
| MYD88 | dabrafenib | 0.9773916 | 0.9990974 | 0.97739 | NA | NA |
| PDGFRB | trametinib | 0.9784811 | 0.9991250 | 0.97848 | NA | NA |
| RIT1 | temozolomide | 0.9786787 | 0.9991250 | 0.97868 | NA | NA |
| PAX8 | midostaurin | 0.9789346 | 0.9991250 | 0.97893 | NA | NA |
| SMC1A | ruxolitinib | 0.9791385 | 0.9991250 | 0.97914 | NA | NA |
| FBXW7 | imatinib | 0.9792390 | 0.9991250 | 0.97924 | NA | NA |
| PRPF40B | vismodegib | 0.9793061 | 0.9991250 | 0.97931 | NA | NA |
| AKT2 | palbociclib | 0.9809077 | 0.9999163 | 0.98091 | NA | NA |
| SH2B3 | rucaparib | 0.9811815 | 0.9999163 | 0.98118 | NA | NA |
| CTCF | palbociclib | 0.9812762 | 0.9999163 | 0.98128 | NA | NA |
| AKT3 | gefitinib | 0.9813410 | 0.9999163 | 0.98134 | NA | NA |
| EED | belinostat | 0.9816838 | 0.9999447 | 0.98168 | NA | NA |
| ATM | gefitinib | 0.9830253 | 0.9999651 | 0.98303 | NA | NA |
| PIK3CA | trametinib | 0.9832477 | 0.9999651 | 0.98325 | NA | NA |
| KRAS | alectinib | 0.9838427 | 0.9999651 | 0.98384 | NA | NA |
| PAX8 | trametinib | 0.9839656 | 0.9999651 | 0.98397 | NA | NA |
| CTNNB1 | vismodegib | 0.9841264 | 0.9999651 | 0.98413 | NA | NA |
| TPMT | bosutinib monohydrate | 0.9847665 | 0.9999651 | 0.98477 | NA | NA |
| ETV6 | sunitinib | 0.9847737 | 0.9999651 | 0.98477 | NA | NA |
| ESR1 | alectinib | 0.9851623 | 0.9999651 | 0.98516 | NA | NA |
| CTCF | sunitinib | 0.9858463 | 0.9999651 | 0.98585 | NA | NA |
| WHSC1 | dabrafenib | 0.9865696 | 0.9999651 | 0.98657 | NA | NA |
| PIK3CA | lapatinib | 0.9866347 | 0.9999651 | 0.98663 | NA | NA |
| MYCN | nilotinib | 0.9867686 | 0.9999651 | 0.98677 | NA | NA |
| KMT2A | tretinoin | 0.9867957 | 0.9999651 | 0.98680 | NA | NA |
| PIK3CA | imatinib | 0.9871324 | 0.9999651 | 0.98713 | NA | NA |
| KMT2A | gefitinib | 0.9877838 | 0.9999651 | 0.98778 | NA | NA |
| PTCH1 | lapatinib | 0.9878187 | 0.9999651 | 0.98782 | NA | NA |
| PTCH1 | imatinib | 0.9882665 | 0.9999651 | 0.98827 | NA | NA |
| JAK2 | ponatinib | 0.9882767 | 0.9999651 | 0.98828 | NA | NA |
| FGFR2 | dabrafenib | 0.9883831 | 0.9999651 | 0.98838 | NA | NA |
| GNB1 | midostaurin | 0.9890693 | 0.9999651 | 0.98907 | NA | NA |
| BCOR | crizotinib | 0.9890817 | 0.9999651 | 0.98908 | NA | NA |
| ATM | palbociclib | 0.9892046 | 0.9999651 | 0.98920 | NA | NA |
| FGFR2 | bosutinib monohydrate | 0.9892432 | 0.9999651 | 0.98924 | NA | NA |
| DNAJB1 | vismodegib | 0.9892602 | 0.9999651 | 0.98926 | NA | NA |
| SH2B3 | belinostat | 0.9899582 | 1.0000000 | 0.98996 | NA | NA |
| FGFR2 | tretinoin | 0.9899834 | 1.0000000 | 0.98998 | NA | NA |
| CBLB | imatinib | 0.9907752 | 1.0000000 | 0.99078 | NA | NA |
| ALK | nilotinib | 0.9911966 | 1.0000000 | 0.99120 | NA | NA |
| ETV6 | afatinib | 0.9917220 | 1.0000000 | 0.99172 | NA | NA |
| PTEN | dasatinib | 0.9918913 | 1.0000000 | 0.99189 | NA | NA |
| EED | ponatinib | 0.9938213 | 1.0000000 | 0.99382 | NA | NA |
| FBXW7 | crizotinib | 0.9940455 | 1.0000000 | 0.99405 | NA | NA |
| JAK1 | imatinib | 0.9944990 | 1.0000000 | 0.99450 | NA | NA |
| FLCN | bosutinib monohydrate | 0.9945924 | 1.0000000 | 0.99459 | NA | NA |
| MGMT | ruxolitinib | 0.9946721 | 1.0000000 | 0.99467 | NA | NA |
| PHF6 | crizotinib | 0.9948625 | 1.0000000 | 0.99486 | NA | NA |
| ROS1 | dabrafenib | 0.9949724 | 1.0000000 | 0.99497 | NA | NA |
| DDIT3 | bosutinib monohydrate | 0.9949740 | 1.0000000 | 0.99497 | NA | NA |
| SMO | alectinib | 0.9950076 | 1.0000000 | 0.99501 | NA | NA |
| CDKN2A | midostaurin | 0.9959831 | 1.0000000 | 0.99598 | NA | NA |
| GATA3 | bosutinib monohydrate | 0.9960502 | 1.0000000 | 0.99605 | NA | NA |
| ZRSR2 | dasatinib | 0.9962487 | 1.0000000 | 0.99625 | NA | NA |
| PAX8 | sunitinib | 0.9962773 | 1.0000000 | 0.99628 | NA | NA |
| WT1 | rucaparib | 0.9967317 | 1.0000000 | 0.99673 | NA | NA |
| ABL1 | tretinoin | 0.9968006 | 1.0000000 | 0.99680 | NA | NA |
| AKT1 | ponatinib | 0.9972326 | 1.0000000 | 0.99723 | NA | NA |
| DNAJB1 | rucaparib | 0.9975452 | 1.0000000 | 0.99755 | NA | NA |
| CREBBP | rucaparib | 0.9980993 | 1.0000000 | 0.99810 | NA | NA |
| PHF6 | palbociclib | 0.9984149 | 1.0000000 | 0.99841 | NA | NA |
| JAK2 | bosutinib monohydrate | 0.9984574 | 1.0000000 | 0.99846 | NA | NA |
| DNMT3A | pazopanib | 0.9995159 | 1.0000000 | 0.99952 | NA | NA |
| BCORL1 | erlotinib | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| EGF | rucaparib | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| FGFR3 | nilotinib | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| IDH1 | belinostat | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| MGMT | imatinib | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| NOTCH2 | docetaxel | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
| PHF6 | afatinib | 1.0000000 | 1.0000000 | 1.00000 | NA | NA |
gdsc_signif_lvlA_ByDrug <- readRDS("./data_munging/rds/gdsc_signif_lvlA_ByDrug.rds")
gdsc_signif_lvlA_ByDrug_all <- rbindlist(gdsc_signif_lvlA_ByDrug, use.names = TRUE)
gdsc_signif_lvlA_ByDrug_all <- gdsc_signif_lvlA_ByDrug_all[order(gdsc_signif_lvlA_ByDrug_all$p.adj),]
knitr::kable(gdsc_signif_lvlA_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: by-drug Wilcoxon test results for Level A point mutations, (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| RET | temozolomide | 0.0026631 | 0.3009325 | 0.0027 | ** | NA |
| ETV6 | pazopanib | 0.0196244 | 0.8210078 | 0.020 |
|
NA |
| BTK | pazopanib | 0.0337522 | 0.8210078 | 0.034 |
|
NA |
| ABL1 | pazopanib | 0.0388839 | 0.8210078 | 0.039 |
|
NA |
| TSC2 | pazopanib | 0.0449679 | 0.8210078 | 0.045 |
|
NA |
| IDH1 | pazopanib | 0.0570399 | 0.8210078 | 0.057 | NA | NA |
| NOTCH2 | pazopanib | 0.0575408 | 0.8210078 | 0.058 | NA | NA |
| FGFR2 | pazopanib | 0.0677256 | 0.8210078 | 0.068 | NA | NA |
| IKZF1 | pazopanib | 0.0687048 | 0.8210078 | 0.069 | NA | NA |
| BRAF | pazopanib | 0.0807087 | 0.8210078 | 0.081 | NA | NA |
| PTCH1 | pazopanib | 0.0811235 | 0.8210078 | 0.081 | NA | NA |
| MGMT | pazopanib | 0.0813611 | 0.8210078 | 0.081 | NA | NA |
| BCORL1 | temozolomide | 0.0233805 | 0.8262472 | 0.0234 |
|
NA |
| EML4 | temozolomide | 0.0335702 | 0.8262472 | 0.0336 |
|
NA |
| TP53 | temozolomide | 0.0377257 | 0.8262472 | 0.0377 |
|
NA |
| JAK1 | temozolomide | 0.0390480 | 0.8262472 | 0.0390 |
|
NA |
| SMO | temozolomide | 0.0482552 | 0.8262472 | 0.0483 |
|
NA |
| DNMT3A | temozolomide | 0.0742813 | 0.8262472 | 0.0743 | NA | NA |
| AKT3 | temozolomide | 0.0813611 | 0.8262472 | 0.0814 | NA | NA |
| ETV6 | temozolomide | 0.1051925 | 0.8262472 | 0.1052 | NA | NA |
| ATM | temozolomide | 0.1077751 | 0.8262472 | 0.1078 | NA | NA |
| CD79B | temozolomide | 0.1116118 | 0.8262472 | 0.1116 | NA | NA |
| TET2 | temozolomide | 0.1149749 | 0.8262472 | 0.1150 | NA | NA |
| PIK3CA | temozolomide | 0.1161003 | 0.8262472 | 0.1161 | NA | NA |
| MGMT | temozolomide | 0.1360371 | 0.8262472 | 0.1360 | NA | NA |
| GNAS | temozolomide | 0.1549743 | 0.8262472 | 0.1550 | NA | NA |
| FBXW7 | temozolomide | 0.1582595 | 0.8262472 | 0.1583 | NA | NA |
| SETBP1 | temozolomide | 0.1661958 | 0.8262472 | 0.1662 | NA | NA |
| MAP2K1 | temozolomide | 0.1752442 | 0.8262472 | 0.1752 | NA | NA |
| HRAS | temozolomide | 0.1752442 | 0.8262472 | 0.1752 | NA | NA |
| FLT3 | temozolomide | 0.1796050 | 0.8262472 | 0.1796 | NA | NA |
| CSF3R | temozolomide | 0.1984493 | 0.8262472 | 0.1984 | NA | NA |
| JAK2 | temozolomide | 0.2048709 | 0.8262472 | 0.2049 | NA | NA |
| STAT3 | temozolomide | 0.2048939 | 0.8262472 | 0.2049 | NA | NA |
| PTEN | temozolomide | 0.2253663 | 0.8262472 | 0.2254 | NA | NA |
| AR | temozolomide | 0.2296941 | 0.8262472 | 0.2297 | NA | NA |
| FGFR2 | temozolomide | 0.2353333 | 0.8262472 | 0.2353 | NA | NA |
| PAX8 | temozolomide | 0.2409547 | 0.8262472 | 0.2410 | NA | NA |
| NPM1 | temozolomide | 0.2471600 | 0.8262472 | 0.2472 | NA | NA |
| PAX5 | temozolomide | 0.2544506 | 0.8262472 | 0.2545 | NA | NA |
| GNB1 | temozolomide | 0.2544506 | 0.8262472 | 0.2545 | NA | NA |
| PDGFRB | temozolomide | 0.2683073 | 0.8262472 | 0.2683 | NA | NA |
| ERBB2 | temozolomide | 0.2704472 | 0.8262472 | 0.2704 | NA | NA |
| ESR1 | temozolomide | 0.2718987 | 0.8262472 | 0.2719 | NA | NA |
| FGFR3 | temozolomide | 0.2744311 | 0.8262472 | 0.2744 | NA | NA |
| FGFR1 | temozolomide | 0.2787627 | 0.8262472 | 0.2788 | NA | NA |
| IL7R | temozolomide | 0.2863206 | 0.8262472 | 0.2863 | NA | NA |
| CTNNB1 | temozolomide | 0.2867038 | 0.8262472 | 0.2867 | NA | NA |
| ABL1 | temozolomide | 0.2903468 | 0.8262472 | 0.2903 | NA | NA |
| ERBB4 | temozolomide | 0.2936694 | 0.8262472 | 0.2937 | NA | NA |
| AKT1 | temozolomide | 0.2938258 | 0.8262472 | 0.2938 | NA | NA |
| VHL | temozolomide | 0.3035890 | 0.8262472 | 0.3036 | NA | NA |
| JAK3 | temozolomide | 0.3073142 | 0.8262472 | 0.3073 | NA | NA |
| CDK4 | temozolomide | 0.3144127 | 0.8262472 | 0.3144 | NA | NA |
| NOTCH2 | temozolomide | 0.3218228 | 0.8264994 | 0.3218 | NA | NA |
| AKT2 | temozolomide | 0.3329216 | 0.8307573 | 0.3329 | NA | NA |
| MET | temozolomide | 0.3405518 | 0.8307573 | 0.3406 | NA | NA |
| TSC1 | temozolomide | 0.3498070 | 0.8307573 | 0.3498 | NA | NA |
| IDH2 | temozolomide | 0.3710934 | 0.8307573 | 0.3711 | NA | NA |
| CDK6 | temozolomide | 0.3710934 | 0.8307573 | 0.3711 | NA | NA |
| SMC3 | temozolomide | 0.3821206 | 0.8307573 | 0.3821 | NA | NA |
| IDH1 | temozolomide | 0.3827331 | 0.8307573 | 0.3827 | NA | NA |
| STAG2 | temozolomide | 0.3855466 | 0.8307573 | 0.3855 | NA | NA |
| KMT2A | temozolomide | 0.3975435 | 0.8307573 | 0.3975 | NA | NA |
| KRAS | temozolomide | 0.3977064 | 0.8307573 | 0.3977 | NA | NA |
| ERBB3 | temozolomide | 0.4088092 | 0.8307573 | 0.4088 | NA | NA |
| BCOR | temozolomide | 0.4117027 | 0.8307573 | 0.4117 | NA | NA |
| MPL | temozolomide | 0.4291953 | 0.8460011 | 0.4292 | NA | NA |
| DNAJB1 | temozolomide | 0.4532547 | 0.8460011 | 0.4533 | NA | NA |
| CBLB | temozolomide | 0.4595426 | 0.8460011 | 0.4595 | NA | NA |
| ASXL1 | temozolomide | 0.4623354 | 0.8460011 | 0.4623 | NA | NA |
| RAD21 | temozolomide | 0.4681599 | 0.8460011 | 0.4682 | NA | NA |
| TSC2 | temozolomide | 0.4844292 | 0.8460011 | 0.4844 | NA | NA |
| RUNX1 | temozolomide | 0.4862343 | 0.8460011 | 0.4862 | NA | NA |
| CALR | temozolomide | 0.4874533 | 0.8460011 | 0.4875 | NA | NA |
| CRLF2 | temozolomide | 0.4874533 | 0.8460011 | 0.4875 | NA | NA |
| SF1 | temozolomide | 0.4941245 | 0.8460011 | 0.4941 | NA | NA |
| FBXW7 | vismodegib | 0.0495864 | 0.8577626 | 0.050 |
|
NA |
| JAK1 | vismodegib | 0.0507543 | 0.8577626 | 0.051 | NA | NA |
| EML4 | vismodegib | 0.0509160 | 0.8577626 | 0.051 | NA | NA |
| SETBP1 | vismodegib | 0.0598774 | 0.8577626 | 0.060 | NA | NA |
| NCOA2 | vismodegib | 0.1107652 | 0.8577626 | 0.111 | NA | NA |
| FLT3 | vismodegib | 0.1180896 | 0.8577626 | 0.118 | NA | NA |
| CSF3R | vismodegib | 0.1375639 | 0.8577626 | 0.138 | NA | NA |
| RET | vismodegib | 0.1389052 | 0.8577626 | 0.139 | NA | NA |
| SF3B1 | vismodegib | 0.1390453 | 0.8577626 | 0.139 | NA | NA |
| ABL1 | vismodegib | 0.1478561 | 0.8577626 | 0.148 | NA | NA |
| DDIT3 | vismodegib | 0.1489147 | 0.8577626 | 0.149 | NA | NA |
| GATA3 | vismodegib | 0.1696541 | 0.8577626 | 0.170 | NA | NA |
| XPO1 | vismodegib | 0.1714602 | 0.8577626 | 0.171 | NA | NA |
| DNMT3A | vismodegib | 0.1730732 | 0.8577626 | 0.173 | NA | NA |
| IDH1 | vismodegib | 0.1904303 | 0.8577626 | 0.190 | NA | NA |
| MPL | vismodegib | 0.1904303 | 0.8577626 | 0.190 | NA | NA |
| TSC1 | vismodegib | 0.2023268 | 0.8577626 | 0.202 | NA | NA |
| CBL | vismodegib | 0.2112995 | 0.8577626 | 0.211 | NA | NA |
| BTK | vismodegib | 0.2193026 | 0.8577626 | 0.219 | NA | NA |
| IL7R | vismodegib | 0.2313504 | 0.8577626 | 0.231 | NA | NA |
| MYD88 | vismodegib | 0.2415666 | 0.8577626 | 0.242 | NA | NA |
| JAK2 | vismodegib | 0.2433046 | 0.8577626 | 0.243 | NA | NA |
| JAK3 | vismodegib | 0.2473671 | 0.8577626 | 0.247 | NA | NA |
| NOTCH1 | vismodegib | 0.2519151 | 0.8577626 | 0.252 | NA | NA |
| ATM | vismodegib | 0.2602462 | 0.8577626 | 0.260 | NA | NA |
| STAG2 | vismodegib | 0.2635525 | 0.8577626 | 0.264 | NA | NA |
| TSC2 | vismodegib | 0.2771857 | 0.8577626 | 0.277 | NA | NA |
| EZH2 | vismodegib | 0.2780757 | 0.8577626 | 0.278 | NA | NA |
| HRAS | vismodegib | 0.2888444 | 0.8577626 | 0.289 | NA | NA |
| BRAF | vismodegib | 0.2890849 | 0.8577626 | 0.289 | NA | NA |
| BCOR | vismodegib | 0.2900957 | 0.8577626 | 0.290 | NA | NA |
| ETV6 | vismodegib | 0.2986177 | 0.8577626 | 0.299 | NA | NA |
| WHSC1 | vismodegib | 0.3166393 | 0.8577626 | 0.317 | NA | NA |
| DPYD | vismodegib | 0.3193494 | 0.8577626 | 0.319 | NA | NA |
| GATA2 | vismodegib | 0.3298592 | 0.8577626 | 0.330 | NA | NA |
| CTCF | vismodegib | 0.3322673 | 0.8577626 | 0.332 | NA | NA |
| GNA11 | vismodegib | 0.3329216 | 0.8577626 | 0.333 | NA | NA |
| CREBBP | vismodegib | 0.3398218 | 0.8577626 | 0.340 | NA | NA |
| CBLB | vismodegib | 0.3525421 | 0.8577626 | 0.353 | NA | NA |
| ESR1 | vismodegib | 0.3552259 | 0.8577626 | 0.355 | NA | NA |
| ZRSR2 | vismodegib | 0.3593968 | 0.8577626 | 0.359 | NA | NA |
| ERBB3 | vismodegib | 0.3635665 | 0.8577626 | 0.364 | NA | NA |
| KRAS | vismodegib | 0.3653976 | 0.8577626 | 0.365 | NA | NA |
| SSX1 | vismodegib | 0.3710934 | 0.8577626 | 0.371 | NA | NA |
| PIK3CA | vismodegib | 0.3748571 | 0.8577626 | 0.375 | NA | NA |
| UGT1A1 | vismodegib | 0.3777807 | 0.8577626 | 0.378 | NA | NA |
| TP53 | vismodegib | 0.3780932 | 0.8577626 | 0.378 | NA | NA |
| NPM1 | vismodegib | 0.3864762 | 0.8577626 | 0.386 | NA | NA |
| G6PD | vismodegib | 0.3864762 | 0.8577626 | 0.386 | NA | NA |
| SRSF2 | vismodegib | 0.3864762 | 0.8577626 | 0.386 | NA | NA |
| FGFR1 | vismodegib | 0.3941071 | 0.8577626 | 0.394 | NA | NA |
| ROS1 | temozolomide | 0.5230400 | 0.8613352 | 0.5230 | NA | NA |
| NCOA2 | temozolomide | 0.5316674 | 0.8613352 | 0.5317 | NA | NA |
| NRAS | temozolomide | 0.5337384 | 0.8613352 | 0.5337 | NA | NA |
| EGFR | temozolomide | 0.5377225 | 0.8613352 | 0.5377 | NA | NA |
| ZRSR2 | temozolomide | 0.5411929 | 0.8613352 | 0.5412 | NA | NA |
| XPO1 | temozolomide | 0.5522142 | 0.8666695 | 0.5522 | NA | NA |
| EGF | temozolomide | 0.5620826 | 0.8700731 | 0.5621 | NA | NA |
| PDGFRB | ponatinib | 0.0365333 | 0.8778615 | 0.037 |
|
NA |
| CBLB | ponatinib | 0.0644577 | 0.8778615 | 0.064 | NA | NA |
| CTNNB1 | ponatinib | 0.0684090 | 0.8778615 | 0.068 | NA | NA |
| SMO | ponatinib | 0.0757091 | 0.8778615 | 0.076 | NA | NA |
| STAG2 | ponatinib | 0.0828374 | 0.8778615 | 0.083 | NA | NA |
| NRAS | ponatinib | 0.0838740 | 0.8778615 | 0.084 | NA | NA |
| CALR | ponatinib | 0.1051925 | 0.8778615 | 0.105 | NA | NA |
| TSC1 | ponatinib | 0.1063243 | 0.8778615 | 0.106 | NA | NA |
| JAK1 | ponatinib | 0.1097093 | 0.8778615 | 0.110 | NA | NA |
| BRCA2 | ponatinib | 0.1303619 | 0.8778615 | 0.130 | NA | NA |
| CDKN2A | ponatinib | 0.1356578 | 0.8778615 | 0.136 | NA | NA |
| ATM | ponatinib | 0.1391840 | 0.8778615 | 0.139 | NA | NA |
| CTCF | ponatinib | 0.1484736 | 0.8778615 | 0.148 | NA | NA |
| BTK | ponatinib | 0.1488365 | 0.8778615 | 0.149 | NA | NA |
| GNA11 | ponatinib | 0.1489147 | 0.8778615 | 0.149 | NA | NA |
| NOTCH1 | ponatinib | 0.1539242 | 0.8778615 | 0.154 | NA | NA |
| BCOR | ponatinib | 0.1623426 | 0.8778615 | 0.162 | NA | NA |
| EZH2 | ponatinib | 0.1630631 | 0.8778615 | 0.163 | NA | NA |
| PAX8 | ponatinib | 0.1658066 | 0.8778615 | 0.166 | NA | NA |
| GNB1 | ponatinib | 0.1714602 | 0.8778615 | 0.171 | NA | NA |
| PTEN | ponatinib | 0.1742555 | 0.8778615 | 0.174 | NA | NA |
| SMC3 | ponatinib | 0.1927903 | 0.8778615 | 0.193 | NA | NA |
| ERBB3 | ponatinib | 0.1942557 | 0.8778615 | 0.194 | NA | NA |
| RAD21 | ponatinib | 0.1966114 | 0.8778615 | 0.197 | NA | NA |
| CSF3R | ponatinib | 0.2027302 | 0.8778615 | 0.203 | NA | NA |
| WHSC1 | ponatinib | 0.2056252 | 0.8778615 | 0.206 | NA | NA |
| BRCA1 | vismodegib | 0.4258825 | 0.8988081 | 0.426 | NA | NA |
| RAD21 | vismodegib | 0.4291606 | 0.8988081 | 0.429 | NA | NA |
| NPM1 | pazopanib | 0.1051925 | 0.8993847 | 0.105 | NA | NA |
| SH2B3 | pazopanib | 0.1206908 | 0.8993847 | 0.121 | NA | NA |
| FLT3 | pazopanib | 0.1253511 | 0.8993847 | 0.125 | NA | NA |
| PDGFRB | pazopanib | 0.1334699 | 0.8993847 | 0.133 | NA | NA |
| SETD2 | pazopanib | 0.1382390 | 0.8993847 | 0.138 | NA | NA |
| MET | pazopanib | 0.1422064 | 0.8993847 | 0.142 | NA | NA |
| IL7R | pazopanib | 0.1551316 | 0.8993847 | 0.155 | NA | NA |
| PRPF8 | pazopanib | 0.1613294 | 0.8993847 | 0.161 | NA | NA |
| MAP2K1 | pazopanib | 0.1637344 | 0.8993847 | 0.164 | NA | NA |
| KMT2A | pazopanib | 0.1883664 | 0.8993847 | 0.188 | NA | NA |
| KIT | pazopanib | 0.1912977 | 0.8993847 | 0.191 | NA | NA |
| NCOA2 | pazopanib | 0.1916946 | 0.8993847 | 0.192 | NA | NA |
| SETBP1 | pazopanib | 0.1985377 | 0.8993847 | 0.199 | NA | NA |
| CREBBP | pazopanib | 0.2112688 | 0.8993847 | 0.211 | NA | NA |
| EGF | pazopanib | 0.2313504 | 0.8993847 | 0.231 | NA | NA |
| SF1 | pazopanib | 0.2330380 | 0.8993847 | 0.233 | NA | NA |
| NT5C2 | pazopanib | 0.2452781 | 0.8993847 | 0.245 | NA | NA |
| CALR | pazopanib | 0.2471600 | 0.8993847 | 0.247 | NA | NA |
| CRLF2 | pazopanib | 0.2471600 | 0.8993847 | 0.247 | NA | NA |
| JAK1 | pazopanib | 0.2532459 | 0.8993847 | 0.253 | NA | NA |
| CBLB | pazopanib | 0.2672575 | 0.8993847 | 0.267 | NA | NA |
| NRAS | pazopanib | 0.2685846 | 0.8993847 | 0.269 | NA | NA |
| FGFR3 | pazopanib | 0.2782314 | 0.8993847 | 0.278 | NA | NA |
| FGFR1 | pazopanib | 0.3052255 | 0.8993847 | 0.305 | NA | NA |
| SF3B1 | pazopanib | 0.3138562 | 0.8993847 | 0.314 | NA | NA |
| EML4 | pazopanib | 0.3140923 | 0.8993847 | 0.314 | NA | NA |
| STAG2 | pazopanib | 0.3153025 | 0.8993847 | 0.315 | NA | NA |
| DPYD | pazopanib | 0.3194547 | 0.8993847 | 0.319 | NA | NA |
| AKT1 | pazopanib | 0.3251627 | 0.8993847 | 0.325 | NA | NA |
| AR | pazopanib | 0.3322052 | 0.8993847 | 0.332 | NA | NA |
| GATA2 | pazopanib | 0.3413493 | 0.9021375 | 0.341 | NA | NA |
| JAK2 | ponatinib | 0.2216120 | 0.9110714 | 0.222 | NA | NA |
| SETD2 | ponatinib | 0.2301306 | 0.9123036 | 0.230 | NA | NA |
| DPYD | temozolomide | 0.6112381 | 0.9145880 | 0.6112 | NA | NA |
| NOTCH1 | temozolomide | 0.6177566 | 0.9145880 | 0.6178 | NA | NA |
| KIT | temozolomide | 0.6238962 | 0.9145880 | 0.6239 | NA | NA |
| PML | temozolomide | 0.6332644 | 0.9145880 | 0.6333 | NA | NA |
| BRAF | temozolomide | 0.6362263 | 0.9145880 | 0.6362 | NA | NA |
| WHSC1 | temozolomide | 0.6394022 | 0.9145880 | 0.6394 | NA | NA |
| BRCA1 | temozolomide | 0.6566664 | 0.9186432 | 0.6567 | NA | NA |
| CBL | temozolomide | 0.6625206 | 0.9186432 | 0.6625 | NA | NA |
| WT1 | temozolomide | 0.6761033 | 0.9186432 | 0.6761 | NA | NA |
| BRCA2 | temozolomide | 0.6821937 | 0.9186432 | 0.6822 | NA | NA |
| CDKN2A | temozolomide | 0.6884095 | 0.9186432 | 0.6884 | NA | NA |
| CTLA4 | temozolomide | 0.6985354 | 0.9186432 | 0.6985 | NA | NA |
| PDGFRA | temozolomide | 0.7070567 | 0.9186432 | 0.7071 | NA | NA |
| CTCF | temozolomide | 0.7092180 | 0.9186432 | 0.7092 | NA | NA |
| PRPF40B | temozolomide | 0.7154036 | 0.9186432 | 0.7154 | NA | NA |
| PAX8 | cabozantinib | 0.0142140 | 0.9193630 | 0.014 |
|
NA |
| GNB1 | cabozantinib | 0.0226545 | 0.9193630 | 0.023 |
|
NA |
| RAD21 | cabozantinib | 0.0480900 | 0.9193630 | 0.048 |
|
NA |
| ROS1 | cabozantinib | 0.0613353 | 0.9193630 | 0.061 | NA | NA |
| BRCA2 | cabozantinib | 0.0613414 | 0.9193630 | 0.061 | NA | NA |
| ZRSR2 | cabozantinib | 0.0667981 | 0.9193630 | 0.067 | NA | NA |
| NRAS | cabozantinib | 0.0722114 | 0.9193630 | 0.072 | NA | NA |
| STAG2 | cabozantinib | 0.0745316 | 0.9193630 | 0.075 | NA | NA |
| SMC3 | cabozantinib | 0.0802844 | 0.9193630 | 0.080 | NA | NA |
| NCOA2 | cabozantinib | 0.0848219 | 0.9193630 | 0.085 | NA | NA |
| CBLB | cabozantinib | 0.1083194 | 0.9193630 | 0.108 | NA | NA |
| PTEN | cabozantinib | 0.1101615 | 0.9193630 | 0.110 | NA | NA |
| CREBBP | cabozantinib | 0.1124400 | 0.9193630 | 0.112 | NA | NA |
| EGF | cabozantinib | 0.1211415 | 0.9193630 | 0.121 | NA | NA |
| EML4 | cabozantinib | 0.1459236 | 0.9193630 | 0.146 | NA | NA |
| DDIT3 | cabozantinib | 0.1489147 | 0.9193630 | 0.149 | NA | NA |
| SRSF2 | cabozantinib | 0.1489147 | 0.9193630 | 0.149 | NA | NA |
| SF3B1 | cabozantinib | 0.1507509 | 0.9193630 | 0.151 | NA | NA |
| AKT3 | cabozantinib | 0.1752442 | 0.9193630 | 0.175 | NA | NA |
| SETD2 | cabozantinib | 0.1798550 | 0.9193630 | 0.180 | NA | NA |
| ESR1 | cabozantinib | 0.1845726 | 0.9193630 | 0.185 | NA | NA |
| TP53 | cabozantinib | 0.2098332 | 0.9193630 | 0.210 | NA | NA |
| DNAJB1 | cabozantinib | 0.2112995 | 0.9193630 | 0.211 | NA | NA |
| SH2B3 | cabozantinib | 0.2353333 | 0.9193630 | 0.235 | NA | NA |
| DPYD | cabozantinib | 0.2389642 | 0.9193630 | 0.239 | NA | NA |
| PDGFB | cabozantinib | 0.2415666 | 0.9193630 | 0.242 | NA | NA |
| CTLA4 | cabozantinib | 0.2452781 | 0.9193630 | 0.245 | NA | NA |
| JAK1 | cabozantinib | 0.2532459 | 0.9193630 | 0.253 | NA | NA |
| FGFR2 | cabozantinib | 0.2842147 | 0.9193630 | 0.284 | NA | NA |
| SETBP1 | cabozantinib | 0.2937080 | 0.9193630 | 0.294 | NA | NA |
| MPL | cabozantinib | 0.2962699 | 0.9193630 | 0.296 | NA | NA |
| BCOR | cabozantinib | 0.3058167 | 0.9193630 | 0.306 | NA | NA |
| CTNNB1 | cabozantinib | 0.3072865 | 0.9193630 | 0.307 | NA | NA |
| SMC1A | cabozantinib | 0.3123214 | 0.9193630 | 0.312 | NA | NA |
| CDK4 | cabozantinib | 0.3144127 | 0.9193630 | 0.314 | NA | NA |
| ATM | cabozantinib | 0.3326874 | 0.9193630 | 0.333 | NA | NA |
| AKT2 | cabozantinib | 0.3329216 | 0.9193630 | 0.333 | NA | NA |
| IDH2 | cabozantinib | 0.3710934 | 0.9193630 | 0.371 | NA | NA |
| SSX1 | cabozantinib | 0.3710934 | 0.9193630 | 0.371 | NA | NA |
| CDK6 | cabozantinib | 0.3710934 | 0.9193630 | 0.371 | NA | NA |
| TET2 | cabozantinib | 0.3791145 | 0.9193630 | 0.379 | NA | NA |
| CD79B | cabozantinib | 0.3827331 | 0.9193630 | 0.383 | NA | NA |
| PTCH1 | cabozantinib | 0.3978820 | 0.9193630 | 0.398 | NA | NA |
| ERBB2 | cabozantinib | 0.4095468 | 0.9193630 | 0.410 | NA | NA |
| AR | cabozantinib | 0.4146659 | 0.9193630 | 0.415 | NA | NA |
| PRPF8 | cabozantinib | 0.4235074 | 0.9193630 | 0.424 | NA | NA |
| PRPF40B | cabozantinib | 0.4352640 | 0.9193630 | 0.435 | NA | NA |
| PDGFRA | cabozantinib | 0.4385081 | 0.9193630 | 0.439 | NA | NA |
| TSC1 | cabozantinib | 0.4442892 | 0.9193630 | 0.444 | NA | NA |
| BTK | cabozantinib | 0.4446962 | 0.9193630 | 0.445 | NA | NA |
| STAT3 | cabozantinib | 0.4468728 | 0.9193630 | 0.447 | NA | NA |
| ERBB3 | cabozantinib | 0.4553522 | 0.9193630 | 0.455 | NA | NA |
| AKT1 | cabozantinib | 0.4605582 | 0.9193630 | 0.461 | NA | NA |
| KIT | cabozantinib | 0.4611737 | 0.9193630 | 0.461 | NA | NA |
| MET | cabozantinib | 0.4699300 | 0.9193630 | 0.470 | NA | NA |
| PML | cabozantinib | 0.4766160 | 0.9193630 | 0.477 | NA | NA |
| CALR | cabozantinib | 0.4874533 | 0.9193630 | 0.487 | NA | NA |
| BCORL1 | cabozantinib | 0.5061157 | 0.9193630 | 0.506 | NA | NA |
| XPO1 | cabozantinib | 0.5083316 | 0.9193630 | 0.508 | NA | NA |
| FGFR1 | cabozantinib | 0.5160638 | 0.9193630 | 0.516 | NA | NA |
| ERBB4 | cabozantinib | 0.5301982 | 0.9193630 | 0.530 | NA | NA |
| EZH2 | cabozantinib | 0.5499800 | 0.9193630 | 0.550 | NA | NA |
| MGMT | cabozantinib | 0.5509850 | 0.9193630 | 0.551 | NA | NA |
| ABL1 | cabozantinib | 0.5517639 | 0.9193630 | 0.552 | NA | NA |
| SMO | cabozantinib | 0.5538183 | 0.9193630 | 0.554 | NA | NA |
| GATA1 | cabozantinib | 0.5565355 | 0.9193630 | 0.557 | NA | NA |
| FBXW7 | cabozantinib | 0.5579963 | 0.9193630 | 0.558 | NA | NA |
| MYD88 | cabozantinib | 0.5581846 | 0.9193630 | 0.558 | NA | NA |
| WT1 | trametinib | 0.0367139 | 0.9200442 | 0.037 |
|
NA |
| CTNNB1 | trametinib | 0.0385722 | 0.9200442 | 0.039 |
|
NA |
| PTEN | trametinib | 0.0473677 | 0.9200442 | 0.047 |
|
NA |
| SF3B1 | trametinib | 0.0479663 | 0.9200442 | 0.048 |
|
NA |
| GATA2 | trametinib | 0.0481324 | 0.9200442 | 0.048 |
|
NA |
| GATA3 | trametinib | 0.0488519 | 0.9200442 | 0.049 |
|
NA |
| SSX1 | pazopanib | 0.3710934 | 0.9221928 | 0.371 | NA | NA |
| CDK6 | pazopanib | 0.3710934 | 0.9221928 | 0.371 | NA | NA |
| GATA1 | pazopanib | 0.3777807 | 0.9221928 | 0.378 | NA | NA |
| DDIT3 | pazopanib | 0.3864762 | 0.9221928 | 0.386 | NA | NA |
| MYCN | pazopanib | 0.3912673 | 0.9221928 | 0.391 | NA | NA |
| WHSC1 | pazopanib | 0.3987861 | 0.9221928 | 0.399 | NA | NA |
| WHSC1 | cabozantinib | 0.5739514 | 0.9316312 | 0.574 | NA | NA |
| VHL | vismodegib | 0.4533555 | 0.9318974 | 0.453 | NA | NA |
| BRCA2 | dabrafenib | 0.0114366 | 0.9357211 | 0.011 |
|
NA |
| DNMT3A | dabrafenib | 0.0231070 | 0.9357211 | 0.023 |
|
NA |
| JAK1 | dabrafenib | 0.0259429 | 0.9357211 | 0.026 |
|
NA |
| EML4 | dabrafenib | 0.0572376 | 0.9357211 | 0.057 | NA | NA |
| KRAS | dabrafenib | 0.0723200 | 0.9357211 | 0.072 | NA | NA |
| XPO1 | dabrafenib | 0.0827310 | 0.9357211 | 0.083 | NA | NA |
| PRPF8 | dabrafenib | 0.0891198 | 0.9357211 | 0.089 | NA | NA |
| SMO | dabrafenib | 0.1008557 | 0.9357211 | 0.101 | NA | NA |
| EZH2 | dabrafenib | 0.1061785 | 0.9357211 | 0.106 | NA | NA |
| BCORL1 | dabrafenib | 0.1251117 | 0.9357211 | 0.125 | NA | NA |
| MET | dabrafenib | 0.1272789 | 0.9357211 | 0.127 | NA | NA |
| BRAF | dabrafenib | 0.1452299 | 0.9357211 | 0.145 | NA | NA |
| CTCF | dabrafenib | 0.1564698 | 0.9357211 | 0.156 | NA | NA |
| AR | dabrafenib | 0.1750566 | 0.9357211 | 0.175 | NA | NA |
| CBL | dabrafenib | 0.1904303 | 0.9357211 | 0.190 | NA | NA |
| STAG2 | dabrafenib | 0.1930591 | 0.9357211 | 0.193 | NA | NA |
| SMC1A | dabrafenib | 0.2159249 | 0.9357211 | 0.216 | NA | NA |
| FLT3 | dabrafenib | 0.2244778 | 0.9357211 | 0.224 | NA | NA |
| JAK3 | dabrafenib | 0.2336459 | 0.9357211 | 0.234 | NA | NA |
| PDGFB | dabrafenib | 0.2415666 | 0.9357211 | 0.242 | NA | NA |
| NT5C2 | dabrafenib | 0.2471600 | 0.9357211 | 0.247 | NA | NA |
| G6PD | dabrafenib | 0.2471600 | 0.9357211 | 0.247 | NA | NA |
| GNB1 | dabrafenib | 0.2544506 | 0.9357211 | 0.254 | NA | NA |
| PML | dabrafenib | 0.2570320 | 0.9357211 | 0.257 | NA | NA |
| RUNX1 | dabrafenib | 0.2962699 | 0.9357211 | 0.296 | NA | NA |
| NCOA2 | dabrafenib | 0.3123214 | 0.9357211 | 0.312 | NA | NA |
| GATA1 | dabrafenib | 0.3129507 | 0.9357211 | 0.313 | NA | NA |
| TP53 | dabrafenib | 0.3320151 | 0.9357211 | 0.332 | NA | NA |
| AKT3 | dabrafenib | 0.3329216 | 0.9357211 | 0.333 | NA | NA |
| FGFR1 | dabrafenib | 0.3532136 | 0.9357211 | 0.353 | NA | NA |
| CBLB | dabrafenib | 0.3552259 | 0.9357211 | 0.355 | NA | NA |
| PAX8 | dabrafenib | 0.3661566 | 0.9357211 | 0.366 | NA | NA |
| DDIT3 | dabrafenib | 0.3710934 | 0.9357211 | 0.371 | NA | NA |
| CDK6 | dabrafenib | 0.3710934 | 0.9357211 | 0.371 | NA | NA |
| NOTCH1 | dabrafenib | 0.3712443 | 0.9357211 | 0.371 | NA | NA |
| CD79B | dabrafenib | 0.3767591 | 0.9357211 | 0.377 | NA | NA |
| MAP2K1 | dabrafenib | 0.3827331 | 0.9357211 | 0.383 | NA | NA |
| CDKN2A | dabrafenib | 0.3873600 | 0.9357211 | 0.387 | NA | NA |
| TSC2 | dabrafenib | 0.3911237 | 0.9357211 | 0.391 | NA | NA |
| WT1 | dabrafenib | 0.3912673 | 0.9357211 | 0.391 | NA | NA |
| KMT2A | dabrafenib | 0.4027293 | 0.9357211 | 0.403 | NA | NA |
| BRCA1 | dabrafenib | 0.4045764 | 0.9357211 | 0.405 | NA | NA |
| GNAS | dabrafenib | 0.4077637 | 0.9357211 | 0.408 | NA | NA |
| PTCH1 | dabrafenib | 0.4156390 | 0.9357211 | 0.416 | NA | NA |
| EGF | dabrafenib | 0.4277675 | 0.9357211 | 0.428 | NA | NA |
| CDK4 | dabrafenib | 0.4344457 | 0.9357211 | 0.434 | NA | NA |
| EGFR | dabrafenib | 0.4410555 | 0.9357211 | 0.441 | NA | NA |
| GATA3 | dabrafenib | 0.4466947 | 0.9357211 | 0.447 | NA | NA |
| IDH1 | dabrafenib | 0.4532547 | 0.9357211 | 0.453 | NA | NA |
| TET2 | dabrafenib | 0.4573905 | 0.9357211 | 0.457 | NA | NA |
| ROS1 | dabrafenib | 0.4708634 | 0.9357211 | 0.471 | NA | NA |
| PIK3CA | dabrafenib | 0.4725223 | 0.9357211 | 0.473 | NA | NA |
| SETD2 | dabrafenib | 0.4832976 | 0.9357211 | 0.483 | NA | NA |
| NOTCH2 | dabrafenib | 0.4843451 | 0.9357211 | 0.484 | NA | NA |
| NPM1 | dabrafenib | 0.4874533 | 0.9357211 | 0.487 | NA | NA |
| CRLF2 | dabrafenib | 0.4874533 | 0.9357211 | 0.487 | NA | NA |
| HRAS | dabrafenib | 0.4874533 | 0.9357211 | 0.487 | NA | NA |
| DPYD | dabrafenib | 0.5253897 | 0.9357211 | 0.525 | NA | NA |
| ABL1 | dabrafenib | 0.5259894 | 0.9357211 | 0.526 | NA | NA |
| JAK2 | dabrafenib | 0.5261475 | 0.9357211 | 0.526 | NA | NA |
| MYCN | dabrafenib | 0.5402914 | 0.9357211 | 0.540 | NA | NA |
| ZRSR2 | dabrafenib | 0.5411929 | 0.9357211 | 0.541 | NA | NA |
| PRPF40B | dabrafenib | 0.5433991 | 0.9357211 | 0.543 | NA | NA |
| CTNNB1 | dabrafenib | 0.5453763 | 0.9357211 | 0.545 | NA | NA |
| MGMT | dabrafenib | 0.5509850 | 0.9357211 | 0.551 | NA | NA |
| MYD88 | dabrafenib | 0.5581846 | 0.9357211 | 0.558 | NA | NA |
| CXCR4 | dabrafenib | 0.5581846 | 0.9357211 | 0.558 | NA | NA |
| ERBB2 | dabrafenib | 0.5630888 | 0.9357211 | 0.563 | NA | NA |
| CTNNB1 | pazopanib | 0.4348101 | 0.9378484 | 0.435 | NA | NA |
| EZH2 | pazopanib | 0.4397098 | 0.9378484 | 0.440 | NA | NA |
| CXCR4 | pazopanib | 0.4532547 | 0.9378484 | 0.453 | NA | NA |
| DNAJB1 | pazopanib | 0.4532547 | 0.9378484 | 0.453 | NA | NA |
| PAX8 | pazopanib | 0.4555451 | 0.9378484 | 0.456 | NA | NA |
| BCOR | pazopanib | 0.4847907 | 0.9378484 | 0.485 | NA | NA |
| NOTCH1 | pazopanib | 0.5211245 | 0.9378484 | 0.521 | NA | NA |
| JAK3 | pazopanib | 0.5282274 | 0.9378484 | 0.528 | NA | NA |
| TP53 | pazopanib | 0.5347727 | 0.9378484 | 0.535 | NA | NA |
| VHL | pazopanib | 0.5393680 | 0.9378484 | 0.539 | NA | NA |
| CTLA4 | pazopanib | 0.5402914 | 0.9378484 | 0.540 | NA | NA |
| CDKN2A | pazopanib | 0.5408422 | 0.9378484 | 0.541 | NA | NA |
| ATM | pazopanib | 0.5485326 | 0.9378484 | 0.549 | NA | NA |
| TSC1 | pazopanib | 0.5518589 | 0.9378484 | 0.552 | NA | NA |
| PDGFB | pazopanib | 0.5581846 | 0.9378484 | 0.558 | NA | NA |
| PML | pazopanib | 0.5601226 | 0.9378484 | 0.560 | NA | NA |
| CBL | pazopanib | 0.5612758 | 0.9378484 | 0.561 | NA | NA |
| SMC3 | pazopanib | 0.5712256 | 0.9378484 | 0.571 | NA | NA |
| CTCF | pazopanib | 0.5781234 | 0.9378484 | 0.578 | NA | NA |
| BRCA2 | pazopanib | 0.5801065 | 0.9378484 | 0.580 | NA | NA |
| GNAS | pazopanib | 0.5829868 | 0.9378484 | 0.583 | NA | NA |
| BRCA2 | ruxolitinib | 0.0613414 | 0.9382521 | 0.061 | NA | NA |
| ERBB4 | ruxolitinib | 0.1006551 | 0.9382521 | 0.101 | NA | NA |
| CALR | ruxolitinib | 0.1051925 | 0.9382521 | 0.105 | NA | NA |
| IDH1 | ruxolitinib | 0.1073465 | 0.9382521 | 0.107 | NA | NA |
| PDGFRA | ruxolitinib | 0.1085452 | 0.9382521 | 0.109 | NA | NA |
| PDGFRB | ruxolitinib | 0.1098305 | 0.9382521 | 0.110 | NA | NA |
| PAX5 | ruxolitinib | 0.1106121 | 0.9382521 | 0.111 | NA | NA |
| AR | ruxolitinib | 0.1179481 | 0.9382521 | 0.118 | NA | NA |
| MGMT | ruxolitinib | 0.1360371 | 0.9382521 | 0.136 | NA | NA |
| RET | ruxolitinib | 0.1392493 | 0.9382521 | 0.139 | NA | NA |
| DDIT3 | ruxolitinib | 0.1489147 | 0.9382521 | 0.149 | NA | NA |
| ATM | ruxolitinib | 0.1501605 | 0.9382521 | 0.150 | NA | NA |
| CBLB | ruxolitinib | 0.1507856 | 0.9382521 | 0.151 | NA | NA |
| STAT3 | ruxolitinib | 0.1507856 | 0.9382521 | 0.151 | NA | NA |
| TET2 | ruxolitinib | 0.1512811 | 0.9382521 | 0.151 | NA | NA |
| FBXW7 | ruxolitinib | 0.1548213 | 0.9382521 | 0.155 | NA | NA |
| AKT3 | ruxolitinib | 0.1752442 | 0.9382521 | 0.175 | NA | NA |
| CSF3R | ruxolitinib | 0.1824224 | 0.9382521 | 0.182 | NA | NA |
| ERBB3 | ruxolitinib | 0.2134248 | 0.9382521 | 0.213 | NA | NA |
| EGFR | ruxolitinib | 0.2223767 | 0.9382521 | 0.222 | NA | NA |
| DNMT3A | ruxolitinib | 0.2236189 | 0.9382521 | 0.224 | NA | NA |
| PAX8 | ruxolitinib | 0.2409547 | 0.9382521 | 0.241 | NA | NA |
| MYD88 | ruxolitinib | 0.2415666 | 0.9382521 | 0.242 | NA | NA |
| SF1 | ruxolitinib | 0.2452781 | 0.9382521 | 0.245 | NA | NA |
| CTLA4 | ruxolitinib | 0.2452781 | 0.9382521 | 0.245 | NA | NA |
| GNB1 | ruxolitinib | 0.2544506 | 0.9382521 | 0.254 | NA | NA |
| WHSC1 | ruxolitinib | 0.2608080 | 0.9382521 | 0.261 | NA | NA |
| DPYD | ruxolitinib | 0.2653106 | 0.9382521 | 0.265 | NA | NA |
| NRAS | ruxolitinib | 0.2685846 | 0.9382521 | 0.269 | NA | NA |
| BCORL1 | ruxolitinib | 0.2847911 | 0.9382521 | 0.285 | NA | NA |
| HRAS | ruxolitinib | 0.2888444 | 0.9382521 | 0.289 | NA | NA |
| XPO1 | ruxolitinib | 0.2986177 | 0.9382521 | 0.299 | NA | NA |
| KMT2A | ruxolitinib | 0.2990397 | 0.9382521 | 0.299 | NA | NA |
| JAK1 | ruxolitinib | 0.3372059 | 0.9382521 | 0.337 | NA | NA |
| FGFR2 | ruxolitinib | 0.3447042 | 0.9382521 | 0.345 | NA | NA |
| GNAS | ruxolitinib | 0.3454721 | 0.9382521 | 0.345 | NA | NA |
| PTEN | ruxolitinib | 0.3490434 | 0.9382521 | 0.349 | NA | NA |
| STAG2 | ruxolitinib | 0.3502376 | 0.9382521 | 0.350 | NA | NA |
| BCOR | ruxolitinib | 0.3595380 | 0.9382521 | 0.360 | NA | NA |
| IDH2 | ruxolitinib | 0.3710934 | 0.9382521 | 0.371 | NA | NA |
| SSX1 | ruxolitinib | 0.3710934 | 0.9382521 | 0.371 | NA | NA |
| CDK6 | ruxolitinib | 0.3710934 | 0.9382521 | 0.371 | NA | NA |
| ABL1 | ruxolitinib | 0.3814787 | 0.9382521 | 0.381 | NA | NA |
| CD79B | ruxolitinib | 0.3827331 | 0.9382521 | 0.383 | NA | NA |
| FGFR1 | ruxolitinib | 0.4037318 | 0.9382521 | 0.404 | NA | NA |
| CREBBP | ruxolitinib | 0.4069927 | 0.9382521 | 0.407 | NA | NA |
| CTCF | ruxolitinib | 0.4119913 | 0.9382521 | 0.412 | NA | NA |
| NCOA2 | ruxolitinib | 0.4334219 | 0.9382521 | 0.433 | NA | NA |
| SMC3 | ruxolitinib | 0.4403309 | 0.9382521 | 0.440 | NA | NA |
| TSC1 | ruxolitinib | 0.4442892 | 0.9382521 | 0.444 | NA | NA |
| CTNNB1 | ruxolitinib | 0.4658564 | 0.9382521 | 0.466 | NA | NA |
| MET | ruxolitinib | 0.4699300 | 0.9382521 | 0.470 | NA | NA |
| SMC1A | ruxolitinib | 0.4704864 | 0.9382521 | 0.470 | NA | NA |
| ESR1 | ruxolitinib | 0.4749585 | 0.9382521 | 0.475 | NA | NA |
| GNA11 | ruxolitinib | 0.4874533 | 0.9382521 | 0.487 | NA | NA |
| SMO | ruxolitinib | 0.4897397 | 0.9382521 | 0.490 | NA | NA |
| BRCA1 | ruxolitinib | 0.5004224 | 0.9382521 | 0.500 | NA | NA |
| SH2B3 | ruxolitinib | 0.5228167 | 0.9382521 | 0.523 | NA | NA |
| ERBB2 | ruxolitinib | 0.5308130 | 0.9382521 | 0.531 | NA | NA |
| BRAF | ruxolitinib | 0.5317794 | 0.9382521 | 0.532 | NA | NA |
| ZRSR2 | ruxolitinib | 0.5411929 | 0.9382521 | 0.541 | NA | NA |
| IKZF1 | ruxolitinib | 0.5439933 | 0.9382521 | 0.544 | NA | NA |
| PML | ruxolitinib | 0.5443086 | 0.9382521 | 0.544 | NA | NA |
| ALK | ruxolitinib | 0.5538155 | 0.9382521 | 0.554 | NA | NA |
| PDGFB | ruxolitinib | 0.5581846 | 0.9382521 | 0.558 | NA | NA |
| AKT2 | ruxolitinib | 0.5612758 | 0.9382521 | 0.561 | NA | NA |
| CBL | ruxolitinib | 0.5612758 | 0.9382521 | 0.561 | NA | NA |
| ALK | pazopanib | 0.5931401 | 0.9405507 | 0.593 | NA | NA |
| CSF3R | dabrafenib | 0.5815410 | 0.9454318 | 0.582 | NA | NA |
| ETV6 | dabrafenib | 0.5891545 | 0.9454318 | 0.589 | NA | NA |
| GATA2 | dabrafenib | 0.5940323 | 0.9454318 | 0.594 | NA | NA |
| AKT3 | vismodegib | 0.4874533 | 0.9510339 | 0.487 | NA | NA |
| NT5C2 | vismodegib | 0.4874533 | 0.9510339 | 0.487 | NA | NA |
| ERBB4 | vismodegib | 0.4883688 | 0.9510339 | 0.488 | NA | NA |
| RUNX1 | pazopanib | 0.6352563 | 0.9535338 | 0.635 | NA | NA |
| GNB1 | pazopanib | 0.6485034 | 0.9535338 | 0.649 | NA | NA |
| TET2 | pazopanib | 0.6521684 | 0.9535338 | 0.652 | NA | NA |
| CD79B | pazopanib | 0.6625206 | 0.9535338 | 0.663 | NA | NA |
| SMC1A | pazopanib | 0.6650055 | 0.9535338 | 0.665 | NA | NA |
| WT1 | pazopanib | 0.6678058 | 0.9535338 | 0.668 | NA | NA |
| PRPF40B | pazopanib | 0.6717534 | 0.9535338 | 0.672 | NA | NA |
| DNMT3A | pazopanib | 0.6849970 | 0.9535338 | 0.685 | NA | NA |
| GATA3 | pazopanib | 0.6871276 | 0.9535338 | 0.687 | NA | NA |
| SMO | pazopanib | 0.6930652 | 0.9535338 | 0.693 | NA | NA |
| BRCA1 | pazopanib | 0.6982607 | 0.9535338 | 0.698 | NA | NA |
| KRAS | pazopanib | 0.7123892 | 0.9535338 | 0.712 | NA | NA |
| MYD88 | pazopanib | 0.7236736 | 0.9535338 | 0.724 | NA | NA |
| CDK4 | pazopanib | 0.7373721 | 0.9535338 | 0.737 | NA | NA |
| ZRSR2 | pazopanib | 0.7599815 | 0.9535338 | 0.760 | NA | NA |
| PDGFRA | pazopanib | 0.7621399 | 0.9535338 | 0.762 | NA | NA |
| SRSF2 | pazopanib | 0.7728300 | 0.9535338 | 0.773 | NA | NA |
| ASXL1 | pazopanib | 0.7749850 | 0.9535338 | 0.775 | NA | NA |
| UGT1A1 | pazopanib | 0.7758198 | 0.9535338 | 0.776 | NA | NA |
| RET | pazopanib | 0.7921474 | 0.9535338 | 0.792 | NA | NA |
| BCORL1 | pazopanib | 0.7947269 | 0.9535338 | 0.795 | NA | NA |
| ERBB3 | pazopanib | 0.7983763 | 0.9535338 | 0.798 | NA | NA |
| CSF3R | pazopanib | 0.7989067 | 0.9535338 | 0.799 | NA | NA |
| ALK | tretinoin | 0.0086111 | 0.9558271 | 0.0086 | ** | NA |
| GATA2 | tretinoin | 0.0347556 | 0.9576410 | 0.0348 |
|
NA |
| FLT3 | tretinoin | 0.0487764 | 0.9576410 | 0.0488 |
|
NA |
| JAK1 | tretinoin | 0.0507543 | 0.9576410 | 0.0508 | NA | NA |
| EML4 | tretinoin | 0.0509160 | 0.9576410 | 0.0509 | NA | NA |
| ZRSR2 | tretinoin | 0.0667981 | 0.9576410 | 0.0668 | NA | NA |
| XPO1 | tretinoin | 0.0682475 | 0.9576410 | 0.0682 | NA | NA |
| CSF3R | tretinoin | 0.0770999 | 0.9576410 | 0.0771 | NA | NA |
| KRAS | tretinoin | 0.0834354 | 0.9576410 | 0.0834 | NA | NA |
| NOTCH2 | tretinoin | 0.0862740 | 0.9576410 | 0.0863 | NA | NA |
| G6PD | pazopanib | 0.8169613 | 0.9577635 | 0.817 | NA | NA |
| PAX5 | pazopanib | 0.8197075 | 0.9577635 | 0.820 | NA | NA |
| EGF | ruxolitinib | 0.5823194 | 0.9591143 | 0.582 | NA | NA |
| AKT3 | pazopanib | 0.8464506 | 0.9686187 | 0.846 | NA | NA |
| AKT2 | pazopanib | 0.8464506 | 0.9686187 | 0.846 | NA | NA |
| PRPF8 | temozolomide | 0.7640767 | 0.9701199 | 0.7641 | NA | NA |
| JAK3 | cabozantinib | 0.6138599 | 0.9701347 | 0.614 | NA | NA |
| BRCA1 | cabozantinib | 0.6468079 | 0.9701347 | 0.647 | NA | NA |
| FLT3 | cabozantinib | 0.6957712 | 0.9701347 | 0.696 | NA | NA |
| CTCF | cabozantinib | 0.7092180 | 0.9701347 | 0.709 | NA | NA |
| CDKN2A | cabozantinib | 0.7136757 | 0.9701347 | 0.714 | NA | NA |
| GATA2 | cabozantinib | 0.7143930 | 0.9701347 | 0.714 | NA | NA |
| IKZF1 | cabozantinib | 0.7158048 | 0.9701347 | 0.716 | NA | NA |
| KRAS | cabozantinib | 0.7218134 | 0.9701347 | 0.722 | NA | NA |
| ETV6 | cabozantinib | 0.7236736 | 0.9701347 | 0.724 | NA | NA |
| HRAS | cabozantinib | 0.7236736 | 0.9701347 | 0.724 | NA | NA |
| FGFR3 | cabozantinib | 0.7554200 | 0.9701347 | 0.755 | NA | NA |
| NT5C2 | cabozantinib | 0.7728300 | 0.9701347 | 0.773 | NA | NA |
| WT1 | cabozantinib | 0.7747957 | 0.9701347 | 0.775 | NA | NA |
| ASXL1 | cabozantinib | 0.7749850 | 0.9701347 | 0.775 | NA | NA |
| CSF3R | cabozantinib | 0.7897258 | 0.9701347 | 0.790 | NA | NA |
| UGT1A1 | cabozantinib | 0.7982151 | 0.9701347 | 0.798 | NA | NA |
| BRAF | cabozantinib | 0.7996672 | 0.9701347 | 0.800 | NA | NA |
| CXCR4 | cabozantinib | 0.8025873 | 0.9701347 | 0.803 | NA | NA |
| TSC2 | cabozantinib | 0.8083330 | 0.9701347 | 0.808 | NA | NA |
| NPM1 | cabozantinib | 0.8169613 | 0.9701347 | 0.817 | NA | NA |
| CRLF2 | cabozantinib | 0.8169613 | 0.9701347 | 0.817 | NA | NA |
| GNA11 | cabozantinib | 0.8169613 | 0.9701347 | 0.817 | NA | NA |
| PAX5 | cabozantinib | 0.8197075 | 0.9701347 | 0.820 | NA | NA |
| ALK | cabozantinib | 0.8285166 | 0.9701347 | 0.829 | NA | NA |
| RET | cabozantinib | 0.8437136 | 0.9701347 | 0.844 | NA | NA |
| NOTCH1 | cabozantinib | 0.8445723 | 0.9701347 | 0.845 | NA | NA |
| CBL | cabozantinib | 0.8464506 | 0.9701347 | 0.846 | NA | NA |
| NOTCH2 | cabozantinib | 0.8541769 | 0.9701347 | 0.854 | NA | NA |
| G6PD | cabozantinib | 0.8596838 | 0.9701347 | 0.860 | NA | NA |
| IL7R | cabozantinib | 0.8668153 | 0.9701347 | 0.867 | NA | NA |
| RUNX1 | cabozantinib | 0.8743671 | 0.9701347 | 0.874 | NA | NA |
| IDH1 | cabozantinib | 0.8836175 | 0.9701347 | 0.884 | NA | NA |
| KMT2A | cabozantinib | 0.8924536 | 0.9701347 | 0.892 | NA | NA |
| SF1 | cabozantinib | 0.8972790 | 0.9701347 | 0.897 | NA | NA |
| GNAS | cabozantinib | 0.9008394 | 0.9701347 | 0.901 | NA | NA |
| TET2 | vismodegib | 0.5099301 | 0.9734628 | 0.510 | NA | NA |
| CTLA4 | vismodegib | 0.5402914 | 0.9734628 | 0.540 | NA | NA |
| BRCA2 | vismodegib | 0.5419273 | 0.9734628 | 0.542 | NA | NA |
| CDKN2A | vismodegib | 0.5474939 | 0.9734628 | 0.547 | NA | NA |
| PDGFB | vismodegib | 0.5581846 | 0.9734628 | 0.558 | NA | NA |
| AKT2 | vismodegib | 0.5581846 | 0.9734628 | 0.558 | NA | NA |
| MAP2K1 | vismodegib | 0.5612758 | 0.9734628 | 0.561 | NA | NA |
| PRPF40B | vismodegib | 0.5703340 | 0.9739551 | 0.570 | NA | NA |
| JAK2 | pazopanib | 0.8613880 | 0.9756538 | 0.861 | NA | NA |
| DNMT3A | nilotinib | 0.0163480 | 0.9770019 | 0.016 |
|
NA |
| NOTCH2 | nilotinib | 0.0476544 | 0.9770019 | 0.048 |
|
NA |
| CTCF | nilotinib | 0.0622469 | 0.9770019 | 0.062 | NA | NA |
| JAK1 | nilotinib | 0.0624074 | 0.9770019 | 0.062 | NA | NA |
| KMT2A | nilotinib | 0.0678512 | 0.9770019 | 0.068 | NA | NA |
| GNAS | nilotinib | 0.0799252 | 0.9770019 | 0.080 | NA | NA |
| BRCA2 | nilotinib | 0.0840391 | 0.9770019 | 0.084 | NA | NA |
| EML4 | nilotinib | 0.0923906 | 0.9770019 | 0.092 | NA | NA |
| BRAF | nilotinib | 0.0954859 | 0.9770019 | 0.095 | NA | NA |
| PDGFRA | nilotinib | 0.0975395 | 0.9770019 | 0.098 | NA | NA |
| FLT3 | nilotinib | 0.1096674 | 0.9770019 | 0.110 | NA | NA |
| AKT1 | nilotinib | 0.1211833 | 0.9770019 | 0.121 | NA | NA |
| IL7R | nilotinib | 0.1296346 | 0.9770019 | 0.130 | NA | NA |
| STAG2 | nilotinib | 0.1488365 | 0.9770019 | 0.149 | NA | NA |
| SRSF2 | nilotinib | 0.1489147 | 0.9770019 | 0.149 | NA | NA |
| BTK | nilotinib | 0.1714602 | 0.9770019 | 0.171 | NA | NA |
| FGFR1 | nilotinib | 0.1727224 | 0.9770019 | 0.173 | NA | NA |
| ABL1 | nilotinib | 0.1744480 | 0.9770019 | 0.174 | NA | NA |
| SMC3 | nilotinib | 0.1751376 | 0.9770019 | 0.175 | NA | NA |
| PTCH1 | nilotinib | 0.1809263 | 0.9770019 | 0.181 | NA | NA |
| BRCA2 | alectinib | 0.0425086 | 0.9803240 | 0.043 |
|
NA |
| G6PD | alectinib | 0.0518299 | 0.9803240 | 0.052 | NA | NA |
| PML | alectinib | 0.0543074 | 0.9803240 | 0.054 | NA | NA |
| ATM | alectinib | 0.0724381 | 0.9803240 | 0.072 | NA | NA |
| TSC1 | alectinib | 0.0742726 | 0.9803240 | 0.074 | NA | NA |
| CSF3R | alectinib | 0.1095986 | 0.9803240 | 0.110 | NA | NA |
| ABL1 | alectinib | 0.1151837 | 0.9803240 | 0.115 | NA | NA |
| PTEN | alectinib | 0.1229807 | 0.9803240 | 0.123 | NA | NA |
| SETD2 | alectinib | 0.1382390 | 0.9803240 | 0.138 | NA | NA |
| DDIT3 | alectinib | 0.1489147 | 0.9803240 | 0.149 | NA | NA |
| STAT3 | alectinib | 0.1507856 | 0.9803240 | 0.151 | NA | NA |
| TET2 | alectinib | 0.1512811 | 0.9803240 | 0.151 | NA | NA |
| ERBB4 | alectinib | 0.1614350 | 0.9803240 | 0.161 | NA | NA |
| PAX5 | alectinib | 0.1714602 | 0.9803240 | 0.171 | NA | NA |
| GNB1 | alectinib | 0.1714602 | 0.9803240 | 0.171 | NA | NA |
| CBL | alectinib | 0.1752442 | 0.9803240 | 0.175 | NA | NA |
| FBXW7 | alectinib | 0.1805649 | 0.9803240 | 0.181 | NA | NA |
| WHSC1 | alectinib | 0.1895548 | 0.9803240 | 0.190 | NA | NA |
| SMC3 | alectinib | 0.1984230 | 0.9803240 | 0.198 | NA | NA |
| DPYD | alectinib | 0.2005345 | 0.9803240 | 0.201 | NA | NA |
| PRPF40B | alectinib | 0.2036473 | 0.9803240 | 0.204 | NA | NA |
| JAK2 | alectinib | 0.2048709 | 0.9803240 | 0.205 | NA | NA |
| ROS1 | alectinib | 0.2063404 | 0.9803240 | 0.206 | NA | NA |
| PDGFRB | alectinib | 0.2476125 | 0.9803240 | 0.248 | NA | NA |
| UGT1A1 | alectinib | 0.2679264 | 0.9803240 | 0.268 | NA | NA |
| HRAS | alectinib | 0.2888444 | 0.9803240 | 0.289 | NA | NA |
| RUNX1 | alectinib | 0.2962699 | 0.9803240 | 0.296 | NA | NA |
| IDH1 | alectinib | 0.3055071 | 0.9803240 | 0.306 | NA | NA |
| AKT2 | alectinib | 0.3329216 | 0.9803240 | 0.333 | NA | NA |
| EGF | alectinib | 0.3421123 | 0.9803240 | 0.342 | NA | NA |
| KMT2A | alectinib | 0.3439441 | 0.9803240 | 0.344 | NA | NA |
| IDH2 | alectinib | 0.3710934 | 0.9803240 | 0.371 | NA | NA |
| SSX1 | alectinib | 0.3710934 | 0.9803240 | 0.371 | NA | NA |
| CDK6 | alectinib | 0.3710934 | 0.9803240 | 0.371 | NA | NA |
| ERBB3 | alectinib | 0.3741554 | 0.9803240 | 0.374 | NA | NA |
| RET | alectinib | 0.3749953 | 0.9803240 | 0.375 | NA | NA |
| CREBBP | alectinib | 0.3807147 | 0.9803240 | 0.381 | NA | NA |
| NT5C2 | alectinib | 0.3864762 | 0.9803240 | 0.386 | NA | NA |
| GNA11 | alectinib | 0.3864762 | 0.9803240 | 0.386 | NA | NA |
| IL7R | alectinib | 0.4017356 | 0.9803240 | 0.402 | NA | NA |
| FGFR1 | alectinib | 0.4037318 | 0.9803240 | 0.404 | NA | NA |
| VHL | alectinib | 0.4131525 | 0.9803240 | 0.413 | NA | NA |
| MET | alectinib | 0.4144753 | 0.9803240 | 0.414 | NA | NA |
| EGFR | alectinib | 0.4396324 | 0.9803240 | 0.440 | NA | NA |
| PTCH1 | alectinib | 0.4467353 | 0.9803240 | 0.447 | NA | NA |
| DNAJB1 | alectinib | 0.4532547 | 0.9803240 | 0.453 | NA | NA |
| MPL | alectinib | 0.4862343 | 0.9803240 | 0.486 | NA | NA |
| NPM1 | alectinib | 0.4874533 | 0.9803240 | 0.487 | NA | NA |
| ERBB2 | alectinib | 0.4884723 | 0.9803240 | 0.488 | NA | NA |
| NOTCH2 | alectinib | 0.5003731 | 0.9803240 | 0.500 | NA | NA |
| BRCA1 | alectinib | 0.5004224 | 0.9803240 | 0.500 | NA | NA |
| CDK4 | alectinib | 0.5024303 | 0.9803240 | 0.502 | NA | NA |
| CDKN2A | alectinib | 0.5089566 | 0.9803240 | 0.509 | NA | NA |
| SF1 | alectinib | 0.5186050 | 0.9803240 | 0.519 | NA | NA |
| NRAS | alectinib | 0.5337384 | 0.9803240 | 0.534 | NA | NA |
| GATA3 | alectinib | 0.5457544 | 0.9803240 | 0.546 | NA | NA |
| MGMT | alectinib | 0.5509850 | 0.9803240 | 0.551 | NA | NA |
| STAG2 | alectinib | 0.5522142 | 0.9803240 | 0.552 | NA | NA |
| BTK | alectinib | 0.5522142 | 0.9803240 | 0.552 | NA | NA |
| RAD21 | alectinib | 0.5532002 | 0.9803240 | 0.553 | NA | NA |
| MYD88 | alectinib | 0.5581846 | 0.9803240 | 0.558 | NA | NA |
| WT1 | alectinib | 0.5671762 | 0.9803240 | 0.567 | NA | NA |
| BCORL1 | alectinib | 0.5828246 | 0.9803240 | 0.583 | NA | NA |
| BRAF | alectinib | 0.6013335 | 0.9803240 | 0.601 | NA | NA |
| GNAS | alectinib | 0.6057116 | 0.9803240 | 0.606 | NA | NA |
| TSC2 | alectinib | 0.6085760 | 0.9803240 | 0.609 | NA | NA |
| AKT1 | alectinib | 0.6227533 | 0.9803240 | 0.623 | NA | NA |
| XPO1 | alectinib | 0.6366016 | 0.9803240 | 0.637 | NA | NA |
| EZH2 | alectinib | 0.6419688 | 0.9803240 | 0.642 | NA | NA |
| CD79B | alectinib | 0.6625206 | 0.9803240 | 0.663 | NA | NA |
| BCOR | alectinib | 0.6663415 | 0.9803240 | 0.666 | NA | NA |
| JAK3 | alectinib | 0.6708487 | 0.9803240 | 0.671 | NA | NA |
| CBLB | alectinib | 0.6726038 | 0.9803240 | 0.673 | NA | NA |
| EML4 | alectinib | 0.6782456 | 0.9803240 | 0.678 | NA | NA |
| JAK1 | alectinib | 0.6889403 | 0.9803240 | 0.689 | NA | NA |
| IKZF1 | alectinib | 0.6950398 | 0.9803240 | 0.695 | NA | NA |
| ESR1 | alectinib | 0.6952986 | 0.9803240 | 0.695 | NA | NA |
| FGFR3 | alectinib | 0.6969981 | 0.9803240 | 0.697 | NA | NA |
| CTLA4 | alectinib | 0.6985354 | 0.9803240 | 0.699 | NA | NA |
| SETBP1 | alectinib | 0.7002314 | 0.9803240 | 0.700 | NA | NA |
| IDH1 | nilotinib | 0.2112995 | 0.9805262 | 0.211 | NA | NA |
| MGMT | nilotinib | 0.2159249 | 0.9805262 | 0.216 | NA | NA |
| CBL | nilotinib | 0.2415666 | 0.9805262 | 0.242 | NA | NA |
| ERBB4 | nilotinib | 0.2420542 | 0.9805262 | 0.242 | NA | NA |
| CRLF2 | nilotinib | 0.2452781 | 0.9805262 | 0.245 | NA | NA |
| RAD21 | nilotinib | 0.2683816 | 0.9805262 | 0.268 | NA | NA |
| JAK2 | nilotinib | 0.2723606 | 0.9805262 | 0.272 | NA | NA |
| NOTCH1 | nilotinib | 0.2741642 | 0.9805262 | 0.274 | NA | NA |
| CREBBP | nilotinib | 0.2770808 | 0.9805262 | 0.277 | NA | NA |
| PRPF8 | nilotinib | 0.2790163 | 0.9805262 | 0.279 | NA | NA |
| TSC2 | nilotinib | 0.2814473 | 0.9805262 | 0.281 | NA | NA |
| GATA2 | alectinib | 0.7143930 | 0.9838674 | 0.714 | NA | NA |
| ETV6 | alectinib | 0.7236736 | 0.9838674 | 0.724 | NA | NA |
| DNMT3A | alectinib | 0.7455421 | 0.9838674 | 0.746 | NA | NA |
| SRSF2 | alectinib | 0.7728300 | 0.9838674 | 0.773 | NA | NA |
| ASXL1 | alectinib | 0.7749850 | 0.9838674 | 0.775 | NA | NA |
| KIT | alectinib | 0.7768479 | 0.9838674 | 0.777 | NA | NA |
| SH2B3 | alectinib | 0.7841912 | 0.9838674 | 0.784 | NA | NA |
| AR | alectinib | 0.7856963 | 0.9838674 | 0.786 | NA | NA |
| FLT3 | alectinib | 0.8034841 | 0.9838674 | 0.803 | NA | NA |
| TP53 | alectinib | 0.8090196 | 0.9838674 | 0.809 | NA | NA |
| CTCF | alectinib | 0.8116170 | 0.9838674 | 0.812 | NA | NA |
| CALR | alectinib | 0.8169613 | 0.9838674 | 0.817 | NA | NA |
| CRLF2 | alectinib | 0.8169613 | 0.9838674 | 0.817 | NA | NA |
| IL7R | dabrafenib | 0.6592430 | 0.9839272 | 0.659 | NA | NA |
| RAD21 | dabrafenib | 0.6633550 | 0.9839272 | 0.663 | NA | NA |
| STAT3 | dabrafenib | 0.6726038 | 0.9839272 | 0.673 | NA | NA |
| ESR1 | dabrafenib | 0.6726038 | 0.9839272 | 0.673 | NA | NA |
| ERBB4 | dabrafenib | 0.6782687 | 0.9839272 | 0.678 | NA | NA |
| PTEN | dabrafenib | 0.6932305 | 0.9839272 | 0.693 | NA | NA |
| CTLA4 | dabrafenib | 0.6985354 | 0.9839272 | 0.699 | NA | NA |
| SF3B1 | dabrafenib | 0.7369989 | 0.9839272 | 0.737 | NA | NA |
| SMC3 | dabrafenib | 0.7382595 | 0.9839272 | 0.738 | NA | NA |
| ASXL1 | dabrafenib | 0.7594122 | 0.9839272 | 0.759 | NA | NA |
| SETBP1 | dabrafenib | 0.7645222 | 0.9839272 | 0.765 | NA | NA |
| SRSF2 | dabrafenib | 0.7728300 | 0.9839272 | 0.773 | NA | NA |
| WHSC1 | dabrafenib | 0.7786177 | 0.9839272 | 0.779 | NA | NA |
| CREBBP | dabrafenib | 0.7956080 | 0.9839272 | 0.796 | NA | NA |
| PDGFRB | dabrafenib | 0.7970155 | 0.9839272 | 0.797 | NA | NA |
| DNAJB1 | dabrafenib | 0.8025873 | 0.9839272 | 0.803 | NA | NA |
| SH2B3 | dabrafenib | 0.8101812 | 0.9839272 | 0.810 | NA | NA |
| GNA11 | dabrafenib | 0.8169613 | 0.9839272 | 0.817 | NA | NA |
| UGT1A1 | dabrafenib | 0.8186240 | 0.9839272 | 0.819 | NA | NA |
| PAX5 | dabrafenib | 0.8197075 | 0.9839272 | 0.820 | NA | NA |
| SF1 | dabrafenib | 0.8197075 | 0.9839272 | 0.820 | NA | NA |
| RET | dabrafenib | 0.8207531 | 0.9839272 | 0.821 | NA | NA |
| ALK | dabrafenib | 0.8226312 | 0.9839272 | 0.823 | NA | NA |
| ERBB3 | dabrafenib | 0.8271954 | 0.9839272 | 0.827 | NA | NA |
| ROS1 | pazopanib | 0.8795672 | 0.9861814 | 0.880 | NA | NA |
| SH2B3 | bosutinib monohydrate | 0.0373364 | 0.9887914 | 0.037 |
|
NA |
| KRAS | bosutinib monohydrate | 0.0811543 | 0.9887914 | 0.081 | NA | NA |
| IL7R | bosutinib monohydrate | 0.1473756 | 0.9887914 | 0.147 | NA | NA |
| ETV6 | bosutinib monohydrate | 0.1563757 | 0.9887914 | 0.156 | NA | NA |
| CTCF | bosutinib monohydrate | 0.1564698 | 0.9887914 | 0.156 | NA | NA |
| EML4 | bosutinib monohydrate | 0.1574639 | 0.9887914 | 0.157 | NA | NA |
| CDKN2A | bosutinib monohydrate | 0.1604541 | 0.9887914 | 0.160 | NA | NA |
| TET2 | bosutinib monohydrate | 0.1682659 | 0.9887914 | 0.168 | NA | NA |
| ABL1 | bosutinib monohydrate | 0.1740072 | 0.9887914 | 0.174 | NA | NA |
| PAX5 | bosutinib monohydrate | 0.1752442 | 0.9887914 | 0.175 | NA | NA |
| NRAS | bosutinib monohydrate | 0.1768343 | 0.9887914 | 0.177 | NA | NA |
| CREBBP | bosutinib monohydrate | 0.1796421 | 0.9887914 | 0.180 | NA | NA |
| SMC3 | bosutinib monohydrate | 0.1802042 | 0.9887914 | 0.180 | NA | NA |
| NCOA2 | bosutinib monohydrate | 0.1877002 | 0.9887914 | 0.188 | NA | NA |
| STAT3 | bosutinib monohydrate | 0.1955617 | 0.9887914 | 0.196 | NA | NA |
| IKZF1 | bosutinib monohydrate | 0.2025950 | 0.9887914 | 0.203 | NA | NA |
| KMT2A | bosutinib monohydrate | 0.2218976 | 0.9887914 | 0.222 | NA | NA |
| UGT1A1 | bosutinib monohydrate | 0.2395988 | 0.9887914 | 0.240 | NA | NA |
| GATA1 | bosutinib monohydrate | 0.2410324 | 0.9887914 | 0.241 | NA | NA |
| MYD88 | bosutinib monohydrate | 0.2415666 | 0.9887914 | 0.242 | NA | NA |
| JAK2 | bosutinib monohydrate | 0.2433046 | 0.9887914 | 0.243 | NA | NA |
| BCORL1 | bosutinib monohydrate | 0.2446568 | 0.9887914 | 0.245 | NA | NA |
| CALR | bosutinib monohydrate | 0.2471600 | 0.9887914 | 0.247 | NA | NA |
| MYCN | bosutinib monohydrate | 0.2703441 | 0.9887914 | 0.270 | NA | NA |
| EZH2 | bosutinib monohydrate | 0.2780757 | 0.9887914 | 0.278 | NA | NA |
| PTCH1 | bosutinib monohydrate | 0.2780850 | 0.9887914 | 0.278 | NA | NA |
| RET | bosutinib monohydrate | 0.2818036 | 0.9887914 | 0.282 | NA | NA |
| PML | bosutinib monohydrate | 0.3058000 | 0.9887914 | 0.306 | NA | NA |
| DPYD | bosutinib monohydrate | 0.3193494 | 0.9887914 | 0.319 | NA | NA |
| MAP2K1 | bosutinib monohydrate | 0.3329216 | 0.9887914 | 0.333 | NA | NA |
| GNA11 | bosutinib monohydrate | 0.3329216 | 0.9887914 | 0.333 | NA | NA |
| PRPF8 | bosutinib monohydrate | 0.3463248 | 0.9887914 | 0.346 | NA | NA |
| TSC1 | bosutinib monohydrate | 0.3498070 | 0.9887914 | 0.350 | NA | NA |
| ZRSR2 | bosutinib monohydrate | 0.3593968 | 0.9887914 | 0.359 | NA | NA |
| IDH2 | bosutinib monohydrate | 0.3710934 | 0.9887914 | 0.371 | NA | NA |
| SSX1 | bosutinib monohydrate | 0.3710934 | 0.9887914 | 0.371 | NA | NA |
| SETBP1 | bosutinib monohydrate | 0.3784295 | 0.9887914 | 0.378 | NA | NA |
| MET | bosutinib monohydrate | 0.3909175 | 0.9887914 | 0.391 | NA | NA |
| ATM | bosutinib monohydrate | 0.4081661 | 0.9887914 | 0.408 | NA | NA |
| GATA2 | bosutinib monohydrate | 0.4167928 | 0.9887914 | 0.417 | NA | NA |
| BRAF | bosutinib monohydrate | 0.4433453 | 0.9887914 | 0.443 | NA | NA |
| TP53 | bosutinib monohydrate | 0.4481954 | 0.9887914 | 0.448 | NA | NA |
| NOTCH2 | bosutinib monohydrate | 0.4622380 | 0.9887914 | 0.462 | NA | NA |
| GNB1 | bosutinib monohydrate | 0.4642143 | 0.9887914 | 0.464 | NA | NA |
| NOTCH1 | bosutinib monohydrate | 0.4748248 | 0.9887914 | 0.475 | NA | NA |
| ASXL1 | bosutinib monohydrate | 0.4824052 | 0.9887914 | 0.482 | NA | NA |
| AKT3 | bosutinib monohydrate | 0.4874533 | 0.9887914 | 0.487 | NA | NA |
| JAK1 | bosutinib monohydrate | 0.4881869 | 0.9887914 | 0.488 | NA | NA |
| BRCA2 | bosutinib monohydrate | 0.4894264 | 0.9887914 | 0.489 | NA | NA |
| XPO1 | bosutinib monohydrate | 0.4941245 | 0.9887914 | 0.494 | NA | NA |
| BTK | bosutinib monohydrate | 0.5083316 | 0.9887914 | 0.508 | NA | NA |
| TSC2 | bosutinib monohydrate | 0.5144026 | 0.9887914 | 0.514 | NA | NA |
| FGFR2 | bosutinib monohydrate | 0.5228167 | 0.9887914 | 0.523 | NA | NA |
| EGFR | bosutinib monohydrate | 0.5259598 | 0.9887914 | 0.526 | NA | NA |
| CTLA4 | bosutinib monohydrate | 0.5402914 | 0.9887914 | 0.540 | NA | NA |
| CBLB | bosutinib monohydrate | 0.5541131 | 0.9887914 | 0.554 | NA | NA |
| GATA3 | bosutinib monohydrate | 0.5561538 | 0.9887914 | 0.556 | NA | NA |
| PDGFB | bosutinib monohydrate | 0.5581846 | 0.9887914 | 0.558 | NA | NA |
| ERBB2 | bosutinib monohydrate | 0.5686660 | 0.9887914 | 0.569 | NA | NA |
| PDGFRB | bosutinib monohydrate | 0.5790997 | 0.9887914 | 0.579 | NA | NA |
| MGMT | bosutinib monohydrate | 0.5958831 | 0.9887914 | 0.596 | NA | NA |
| STAG2 | bosutinib monohydrate | 0.6018450 | 0.9887914 | 0.602 | NA | NA |
| BCOR | bosutinib monohydrate | 0.6087261 | 0.9887914 | 0.609 | NA | NA |
| DNMT3A | bosutinib monohydrate | 0.6094224 | 0.9887914 | 0.609 | NA | NA |
| SETD2 | bosutinib monohydrate | 0.6101784 | 0.9887914 | 0.610 | NA | NA |
| ALK | bosutinib monohydrate | 0.6158014 | 0.9887914 | 0.616 | NA | NA |
| CSF3R | bosutinib monohydrate | 0.6206179 | 0.9887914 | 0.621 | NA | NA |
| PIGA | bosutinib monohydrate | 0.6373519 | 0.9887914 | 0.637 | NA | NA |
| ERBB4 | bosutinib monohydrate | 0.6441264 | 0.9887914 | 0.644 | NA | NA |
| GNAS | bosutinib monohydrate | 0.6456944 | 0.9887914 | 0.646 | NA | NA |
| VHL | bosutinib monohydrate | 0.6527828 | 0.9887914 | 0.653 | NA | NA |
| FGFR3 | bosutinib monohydrate | 0.6543166 | 0.9887914 | 0.654 | NA | NA |
| IDH1 | bosutinib monohydrate | 0.6625206 | 0.9887914 | 0.663 | NA | NA |
| MPL | bosutinib monohydrate | 0.6625206 | 0.9887914 | 0.663 | NA | NA |
| BRCA1 | bosutinib monohydrate | 0.6681023 | 0.9887914 | 0.668 | NA | NA |
| CDK4 | bosutinib monohydrate | 0.6959426 | 0.9900099 | 0.696 | NA | NA |
| ESR1 | bosutinib monohydrate | 0.7115314 | 0.9900099 | 0.712 | NA | NA |
| AKT1 | bosutinib monohydrate | 0.7212767 | 0.9900099 | 0.721 | NA | NA |
| HRAS | bosutinib monohydrate | 0.7236736 | 0.9900099 | 0.724 | NA | NA |
| ERBB3 | bosutinib monohydrate | 0.7411004 | 0.9900099 | 0.741 | NA | NA |
| SF1 | bosutinib monohydrate | 0.7655945 | 0.9900099 | 0.766 | NA | NA |
| G6PD | bosutinib monohydrate | 0.7728300 | 0.9900099 | 0.773 | NA | NA |
| CRLF2 | bosutinib monohydrate | 0.7728300 | 0.9900099 | 0.773 | NA | NA |
| DDIT3 | bosutinib monohydrate | 0.7728300 | 0.9900099 | 0.773 | NA | NA |
| SRSF2 | bosutinib monohydrate | 0.7728300 | 0.9900099 | 0.773 | NA | NA |
| KIT | bosutinib monohydrate | 0.7770588 | 0.9900099 | 0.777 | NA | NA |
| CXCR4 | bosutinib monohydrate | 0.8025873 | 0.9900099 | 0.803 | NA | NA |
| CBL | bosutinib monohydrate | 0.8025873 | 0.9900099 | 0.803 | NA | NA |
| FBXW7 | bosutinib monohydrate | 0.8107543 | 0.9900099 | 0.811 | NA | NA |
| PIK3CA | bosutinib monohydrate | 0.8326621 | 0.9900099 | 0.833 | NA | NA |
| CTNNB1 | bosutinib monohydrate | 0.8382078 | 0.9900099 | 0.838 | NA | NA |
| RAD21 | bosutinib monohydrate | 0.8433133 | 0.9900099 | 0.843 | NA | NA |
| PTEN | bosutinib monohydrate | 0.8593387 | 0.9900099 | 0.859 | NA | NA |
| SMC1A | bosutinib monohydrate | 0.8596838 | 0.9900099 | 0.860 | NA | NA |
| FGFR1 | bosutinib monohydrate | 0.8646653 | 0.9900099 | 0.865 | NA | NA |
| WHSC1 | bosutinib monohydrate | 0.8743671 | 0.9900099 | 0.874 | NA | NA |
| JAK3 | bosutinib monohydrate | 0.8850299 | 0.9900099 | 0.885 | NA | NA |
| PRPF40B | bosutinib monohydrate | 0.8871670 | 0.9900099 | 0.887 | NA | NA |
| AR | bosutinib monohydrate | 0.8918595 | 0.9900099 | 0.892 | NA | NA |
| FLT3 | bosutinib monohydrate | 0.8919008 | 0.9900099 | 0.892 | NA | NA |
| NOTCH2 | rucaparib | 0.0122855 | 0.9906346 | 0.012 |
|
NA |
| SMO | rucaparib | 0.0349018 | 0.9906346 | 0.035 |
|
NA |
| PML | rucaparib | 0.0531547 | 0.9906346 | 0.053 | NA | NA |
| NCOA2 | rucaparib | 0.0606020 | 0.9906346 | 0.061 | NA | NA |
| TP53 | rucaparib | 0.0649811 | 0.9906346 | 0.065 | NA | NA |
| STAT3 | rucaparib | 0.0759270 | 0.9906346 | 0.076 | NA | NA |
| EML4 | rucaparib | 0.0806023 | 0.9906346 | 0.081 | NA | NA |
| TSC2 | rucaparib | 0.1005657 | 0.9906346 | 0.101 | NA | NA |
| AKT2 | rucaparib | 0.1051925 | 0.9906346 | 0.105 | NA | NA |
| DNMT3A | rucaparib | 0.1231989 | 0.9906346 | 0.123 | NA | NA |
| ZRSR2 | rucaparib | 0.1266305 | 0.9906346 | 0.127 | NA | NA |
| ABL1 | rucaparib | 0.1274444 | 0.9906346 | 0.127 | NA | NA |
| CDKN2A | rucaparib | 0.1356578 | 0.9906346 | 0.136 | NA | NA |
| DPYD | rucaparib | 0.1413838 | 0.9906346 | 0.141 | NA | NA |
| BTK | rucaparib | 0.1488365 | 0.9906346 | 0.149 | NA | NA |
| FBXW7 | rucaparib | 0.1548213 | 0.9906346 | 0.155 | NA | NA |
| SF1 | rucaparib | 0.1714602 | 0.9906346 | 0.171 | NA | NA |
| GNA11 | rucaparib | 0.1752442 | 0.9906346 | 0.175 | NA | NA |
| CDK4 | rucaparib | 0.1798096 | 0.9906346 | 0.180 | NA | NA |
| GNAS | rucaparib | 0.1872701 | 0.9906346 | 0.187 | NA | NA |
| CTCF | rucaparib | 0.2048400 | 0.9906346 | 0.205 | NA | NA |
| JAK2 | rucaparib | 0.2048709 | 0.9906346 | 0.205 | NA | NA |
| KIT | rucaparib | 0.2202589 | 0.9906346 | 0.220 | NA | NA |
| ETV6 | rucaparib | 0.2293319 | 0.9906346 | 0.229 | NA | NA |
| PDGFB | rucaparib | 0.2415666 | 0.9906346 | 0.242 | NA | NA |
| GNB1 | rucaparib | 0.2452781 | 0.9906346 | 0.245 | NA | NA |
| NPM1 | rucaparib | 0.2471600 | 0.9906346 | 0.247 | NA | NA |
| SETD2 | rucaparib | 0.2479467 | 0.9906346 | 0.248 | NA | NA |
| STAG2 | rucaparib | 0.2696061 | 0.9906346 | 0.270 | NA | NA |
| PTCH1 | rucaparib | 0.2911042 | 0.9906346 | 0.291 | NA | NA |
| RUNX1 | rucaparib | 0.2962699 | 0.9906346 | 0.296 | NA | NA |
| BCORL1 | rucaparib | 0.3268698 | 0.9906346 | 0.327 | NA | NA |
| MAP2K1 | rucaparib | 0.3329216 | 0.9906346 | 0.333 | NA | NA |
| AR | rucaparib | 0.3412685 | 0.9906346 | 0.341 | NA | NA |
| FGFR1 | rucaparib | 0.3532136 | 0.9906346 | 0.353 | NA | NA |
| PDGFRB | rucaparib | 0.3622401 | 0.9906346 | 0.362 | NA | NA |
| IDH2 | rucaparib | 0.3710934 | 0.9906346 | 0.371 | NA | NA |
| MGMT | rucaparib | 0.3710934 | 0.9906346 | 0.371 | NA | NA |
| SSX1 | rucaparib | 0.3710934 | 0.9906346 | 0.371 | NA | NA |
| CDK6 | rucaparib | 0.3710934 | 0.9906346 | 0.371 | NA | NA |
| EGF | rucaparib | 0.3749953 | 0.9906346 | 0.375 | NA | NA |
| CBL | rucaparib | 0.3827331 | 0.9906346 | 0.383 | NA | NA |
| IKZF1 | rucaparib | 0.3956034 | 0.9906346 | 0.396 | NA | NA |
| IDH1 | rucaparib | 0.4046568 | 0.9906346 | 0.405 | NA | NA |
| GATA2 | rucaparib | 0.4207518 | 0.9906346 | 0.421 | NA | NA |
| CSF3R | rucaparib | 0.4259831 | 0.9906346 | 0.426 | NA | NA |
| RAD21 | rucaparib | 0.4291606 | 0.9906346 | 0.429 | NA | NA |
| RET | rucaparib | 0.4303561 | 0.9906346 | 0.430 | NA | NA |
| BCOR | rucaparib | 0.4447379 | 0.9906346 | 0.445 | NA | NA |
| PTEN | rucaparib | 0.4507199 | 0.9906346 | 0.451 | NA | NA |
| CXCR4 | rucaparib | 0.4532547 | 0.9906346 | 0.453 | NA | NA |
| DNAJB1 | rucaparib | 0.4532547 | 0.9906346 | 0.453 | NA | NA |
| AKT1 | rucaparib | 0.4605582 | 0.9906346 | 0.461 | NA | NA |
| DNMT3A | cabozantinib | 0.9353380 | 0.9944450 | 0.935 | NA | NA |
| PDGFRB | cabozantinib | 0.9411712 | 0.9944450 | 0.941 | NA | NA |
| ASXL1 | ponatinib | 0.2662760 | 0.9949427 | 0.266 | NA | NA |
| SETBP1 | ponatinib | 0.2689034 | 0.9949427 | 0.269 | NA | NA |
| UGT1A1 | ponatinib | 0.2964117 | 0.9961775 | 0.296 | NA | NA |
| NOTCH2 | ponatinib | 0.2976500 | 0.9961775 | 0.298 | NA | NA |
| ERBB2 | ponatinib | 0.3064888 | 0.9961775 | 0.306 | NA | NA |
| DPYD | ponatinib | 0.3103990 | 0.9961775 | 0.310 | NA | NA |
| FBXW7 | ponatinib | 0.3150527 | 0.9961775 | 0.315 | NA | NA |
| KRAS | ponatinib | 0.3291457 | 0.9961775 | 0.329 | NA | NA |
| GATA2 | ponatinib | 0.3413493 | 0.9961775 | 0.341 | NA | NA |
| IDH2 | ponatinib | 0.3710934 | 0.9961775 | 0.371 | NA | NA |
| SSX1 | ponatinib | 0.3710934 | 0.9961775 | 0.371 | NA | NA |
| CDK6 | ponatinib | 0.3710934 | 0.9961775 | 0.371 | NA | NA |
| NT5C2 | ponatinib | 0.3864762 | 0.9961775 | 0.386 | NA | NA |
| PML | ponatinib | 0.3897250 | 0.9961775 | 0.390 | NA | NA |
| IL7R | ponatinib | 0.4017356 | 0.9961775 | 0.402 | NA | NA |
| ROS1 | ponatinib | 0.4046482 | 0.9961775 | 0.405 | NA | NA |
| SH2B3 | ponatinib | 0.4113138 | 0.9961775 | 0.411 | NA | NA |
| EGF | ponatinib | 0.4128303 | 0.9961775 | 0.413 | NA | NA |
| AKT2 | dabrafenib | 0.8464506 | 0.9963429 | 0.846 | NA | NA |
| CTNNB1 | alectinib | 0.8382078 | 0.9979207 | 0.838 | NA | NA |
| AKT3 | alectinib | 0.8464506 | 0.9979207 | 0.846 | NA | NA |
| EGFR | cabozantinib | 0.9675555 | 1.0000000 | 0.968 | NA | NA |
| MYCN | cabozantinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| VHL | cabozantinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MAP2K1 | cabozantinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA3 | cabozantinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| JAK2 | cabozantinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| IKZF1 | temozolomide | 0.8151350 | 1.0000000 | 0.8151 | NA | NA |
| NT5C2 | temozolomide | 0.8169613 | 1.0000000 | 0.8170 | NA | NA |
| ALK | temozolomide | 0.8226312 | 1.0000000 | 0.8226 | NA | NA |
| GATA1 | temozolomide | 0.8262384 | 1.0000000 | 0.8262 | NA | NA |
| GNA11 | temozolomide | 0.8464506 | 1.0000000 | 0.8465 | NA | NA |
| SMC1A | temozolomide | 0.8852339 | 1.0000000 | 0.8852 | NA | NA |
| PTCH1 | temozolomide | 0.8874958 | 1.0000000 | 0.8875 | NA | NA |
| MYCN | temozolomide | 0.9025233 | 1.0000000 | 0.9025 | NA | NA |
| SF3B1 | temozolomide | 0.9108683 | 1.0000000 | 0.9109 | NA | NA |
| GATA3 | temozolomide | 0.9252649 | 1.0000000 | 0.9253 | NA | NA |
| BTK | temozolomide | 0.9323244 | 1.0000000 | 0.9323 | NA | NA |
| EZH2 | temozolomide | 0.9439995 | 1.0000000 | 0.9440 | NA | NA |
| CREBBP | temozolomide | 0.9595413 | 1.0000000 | 0.9595 | NA | NA |
| GATA2 | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| MYD88 | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| SETD2 | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| PDGFB | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| SH2B3 | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| G6PD | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| PIGA | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| UGT1A1 | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| CXCR4 | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| DDIT3 | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| SRSF2 | temozolomide | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| RUNX1 | ruxolitinib | 0.6352563 | 1.0000000 | 0.635 | NA | NA |
| UGT1A1 | ruxolitinib | 0.6700376 | 1.0000000 | 0.670 | NA | NA |
| GATA3 | ruxolitinib | 0.6871276 | 1.0000000 | 0.687 | NA | NA |
| SF3B1 | ruxolitinib | 0.7131901 | 1.0000000 | 0.713 | NA | NA |
| EZH2 | ruxolitinib | 0.7254235 | 1.0000000 | 0.725 | NA | NA |
| EML4 | ruxolitinib | 0.7372047 | 1.0000000 | 0.737 | NA | NA |
| KRAS | ruxolitinib | 0.7492585 | 1.0000000 | 0.749 | NA | NA |
| JAK2 | ruxolitinib | 0.7512824 | 1.0000000 | 0.751 | NA | NA |
| ROS1 | ruxolitinib | 0.7551582 | 1.0000000 | 0.755 | NA | NA |
| PRPF8 | ruxolitinib | 0.7640767 | 1.0000000 | 0.764 | NA | NA |
| GATA1 | ruxolitinib | 0.7687598 | 1.0000000 | 0.769 | NA | NA |
| NT5C2 | ruxolitinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| SRSF2 | ruxolitinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| WT1 | ruxolitinib | 0.7747957 | 1.0000000 | 0.775 | NA | NA |
| TSC2 | ruxolitinib | 0.7770820 | 1.0000000 | 0.777 | NA | NA |
| PRPF40B | ruxolitinib | 0.7993057 | 1.0000000 | 0.799 | NA | NA |
| JAK3 | ruxolitinib | 0.8008203 | 1.0000000 | 0.801 | NA | NA |
| CXCR4 | ruxolitinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| DNAJB1 | ruxolitinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| CRLF2 | ruxolitinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| SETBP1 | ruxolitinib | 0.8250003 | 1.0000000 | 0.825 | NA | NA |
| ETV6 | ruxolitinib | 0.8320040 | 1.0000000 | 0.832 | NA | NA |
| MYCN | ruxolitinib | 0.8345316 | 1.0000000 | 0.835 | NA | NA |
| NOTCH2 | ruxolitinib | 0.8541769 | 1.0000000 | 0.854 | NA | NA |
| CDKN2A | ruxolitinib | 0.8640420 | 1.0000000 | 0.864 | NA | NA |
| KIT | ruxolitinib | 0.8649650 | 1.0000000 | 0.865 | NA | NA |
| SETD2 | ruxolitinib | 0.8691731 | 1.0000000 | 0.869 | NA | NA |
| ASXL1 | ruxolitinib | 0.8738175 | 1.0000000 | 0.874 | NA | NA |
| AKT1 | ruxolitinib | 0.8807910 | 1.0000000 | 0.881 | NA | NA |
| NOTCH1 | ruxolitinib | 0.9148401 | 1.0000000 | 0.915 | NA | NA |
| BTK | ruxolitinib | 0.9323244 | 1.0000000 | 0.932 | NA | NA |
| FLT3 | ruxolitinib | 0.9353380 | 1.0000000 | 0.935 | NA | NA |
| FGFR3 | ruxolitinib | 0.9379273 | 1.0000000 | 0.938 | NA | NA |
| GATA2 | ruxolitinib | 0.9416529 | 1.0000000 | 0.942 | NA | NA |
| IL7R | ruxolitinib | 0.9554201 | 1.0000000 | 0.955 | NA | NA |
| PTCH1 | ruxolitinib | 0.9662831 | 1.0000000 | 0.966 | NA | NA |
| TP53 | ruxolitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NPM1 | ruxolitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| RAD21 | ruxolitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| VHL | ruxolitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MAP2K1 | ruxolitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| G6PD | ruxolitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MPL | ruxolitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CDK4 | ruxolitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AR | gefitinib | 0.0486896 | 1.0000000 | 0.049 |
|
NA |
| KIT | gefitinib | 0.0893335 | 1.0000000 | 0.089 | NA | NA |
| ESR1 | gefitinib | 0.0960923 | 1.0000000 | 0.096 | NA | NA |
| GATA2 | gefitinib | 0.1043767 | 1.0000000 | 0.104 | NA | NA |
| SF1 | gefitinib | 0.1116118 | 1.0000000 | 0.112 | NA | NA |
| TP53 | gefitinib | 0.1299556 | 1.0000000 | 0.130 | NA | NA |
| STAG2 | gefitinib | 0.1314573 | 1.0000000 | 0.131 | NA | NA |
| PDGFRB | gefitinib | 0.1321661 | 1.0000000 | 0.132 | NA | NA |
| ALK | gefitinib | 0.1322138 | 1.0000000 | 0.132 | NA | NA |
| FGFR2 | gefitinib | 0.1387688 | 1.0000000 | 0.139 | NA | NA |
| FLT3 | gefitinib | 0.1441929 | 1.0000000 | 0.144 | NA | NA |
| JAK1 | gefitinib | 0.1472235 | 1.0000000 | 0.147 | NA | NA |
| IL7R | gefitinib | 0.1473756 | 1.0000000 | 0.147 | NA | NA |
| CSF3R | gefitinib | 0.1791092 | 1.0000000 | 0.179 | NA | NA |
| GNB1 | gefitinib | 0.1876828 | 1.0000000 | 0.188 | NA | NA |
| EGF | gefitinib | 0.1928758 | 1.0000000 | 0.193 | NA | NA |
| EML4 | gefitinib | 0.2008903 | 1.0000000 | 0.201 | NA | NA |
| IKZF1 | gefitinib | 0.2025950 | 1.0000000 | 0.203 | NA | NA |
| ASXL1 | gefitinib | 0.2060898 | 1.0000000 | 0.206 | NA | NA |
| CTNNB1 | gefitinib | 0.2097372 | 1.0000000 | 0.210 | NA | NA |
| IDH1 | gefitinib | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| ZRSR2 | gefitinib | 0.2217000 | 1.0000000 | 0.222 | NA | NA |
| SF3B1 | gefitinib | 0.2366172 | 1.0000000 | 0.237 | NA | NA |
| GATA1 | gefitinib | 0.2410324 | 1.0000000 | 0.241 | NA | NA |
| PDGFB | gefitinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| ERBB4 | gefitinib | 0.2481548 | 1.0000000 | 0.248 | NA | NA |
| VHL | gefitinib | 0.2938258 | 1.0000000 | 0.294 | NA | NA |
| FGFR3 | gefitinib | 0.2961130 | 1.0000000 | 0.296 | NA | NA |
| RAD21 | gefitinib | 0.3230126 | 1.0000000 | 0.323 | NA | NA |
| PIK3CA | gefitinib | 0.3406277 | 1.0000000 | 0.341 | NA | NA |
| SMO | gefitinib | 0.3424858 | 1.0000000 | 0.342 | NA | NA |
| WT1 | gefitinib | 0.3709136 | 1.0000000 | 0.371 | NA | NA |
| IDH2 | gefitinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| SSX1 | gefitinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| EGFR | gefitinib | 0.3746163 | 1.0000000 | 0.375 | NA | NA |
| SMC1A | gefitinib | 0.3767591 | 1.0000000 | 0.377 | NA | NA |
| MPL | gefitinib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| EZH2 | gefitinib | 0.3855466 | 1.0000000 | 0.386 | NA | NA |
| BTK | gefitinib | 0.3950916 | 1.0000000 | 0.395 | NA | NA |
| SETD2 | gefitinib | 0.3954929 | 1.0000000 | 0.395 | NA | NA |
| PRPF8 | gefitinib | 0.4195470 | 1.0000000 | 0.420 | NA | NA |
| FBXW7 | gefitinib | 0.4207755 | 1.0000000 | 0.421 | NA | NA |
| NOTCH2 | gefitinib | 0.4257818 | 1.0000000 | 0.426 | NA | NA |
| CDK4 | gefitinib | 0.4344457 | 1.0000000 | 0.434 | NA | NA |
| TSC2 | gefitinib | 0.4571931 | 1.0000000 | 0.457 | NA | NA |
| NRAS | gefitinib | 0.4699489 | 1.0000000 | 0.470 | NA | NA |
| CD79B | gefitinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| BRCA1 | gefitinib | 0.5004663 | 1.0000000 | 0.500 | NA | NA |
| SETBP1 | gefitinib | 0.5253819 | 1.0000000 | 0.525 | NA | NA |
| NCOA2 | gefitinib | 0.5326028 | 1.0000000 | 0.533 | NA | NA |
| BRCA2 | gefitinib | 0.5419273 | 1.0000000 | 0.542 | NA | NA |
| TSC1 | gefitinib | 0.5518589 | 1.0000000 | 0.552 | NA | NA |
| GATA3 | gefitinib | 0.5561538 | 1.0000000 | 0.556 | NA | NA |
| MYD88 | gefitinib | 0.5581846 | 1.0000000 | 0.558 | NA | NA |
| MAP2K1 | gefitinib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| ABL1 | gefitinib | 0.5686182 | 1.0000000 | 0.569 | NA | NA |
| ERBB2 | gefitinib | 0.5686660 | 1.0000000 | 0.569 | NA | NA |
| ERBB3 | gefitinib | 0.5703202 | 1.0000000 | 0.570 | NA | NA |
| KRAS | gefitinib | 0.5740869 | 1.0000000 | 0.574 | NA | NA |
| TET2 | gefitinib | 0.5897916 | 1.0000000 | 0.590 | NA | NA |
| RET | gefitinib | 0.5904816 | 1.0000000 | 0.590 | NA | NA |
| FGFR1 | gefitinib | 0.6091301 | 1.0000000 | 0.609 | NA | NA |
| NOTCH1 | gefitinib | 0.6097258 | 1.0000000 | 0.610 | NA | NA |
| DPYD | gefitinib | 0.6316134 | 1.0000000 | 0.632 | NA | NA |
| ETV6 | gefitinib | 0.6366016 | 1.0000000 | 0.637 | NA | NA |
| AKT1 | gefitinib | 0.6385921 | 1.0000000 | 0.639 | NA | NA |
| SMC3 | gefitinib | 0.6411217 | 1.0000000 | 0.641 | NA | NA |
| BCORL1 | gefitinib | 0.6981577 | 1.0000000 | 0.698 | NA | NA |
| GNAS | gefitinib | 0.7040976 | 1.0000000 | 0.704 | NA | NA |
| MYCN | gefitinib | 0.7133032 | 1.0000000 | 0.713 | NA | NA |
| SH2B3 | gefitinib | 0.7133032 | 1.0000000 | 0.713 | NA | NA |
| AKT3 | gefitinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| DNMT3A | gefitinib | 0.7334056 | 1.0000000 | 0.733 | NA | NA |
| PAX8 | gefitinib | 0.7655945 | 1.0000000 | 0.766 | NA | NA |
| G6PD | gefitinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| CRLF2 | gefitinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| DDIT3 | gefitinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| SRSF2 | gefitinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| PRPF40B | gefitinib | 0.7765791 | 1.0000000 | 0.777 | NA | NA |
| BRAF | gefitinib | 0.8022452 | 1.0000000 | 0.802 | NA | NA |
| CXCR4 | gefitinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| CBL | gefitinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| XPO1 | gefitinib | 0.8197075 | 1.0000000 | 0.820 | NA | NA |
| CTCF | gefitinib | 0.8229566 | 1.0000000 | 0.823 | NA | NA |
| KMT2A | gefitinib | 0.8347625 | 1.0000000 | 0.835 | NA | NA |
| PAX5 | gefitinib | 0.8464506 | 1.0000000 | 0.846 | NA | NA |
| GNA11 | gefitinib | 0.8464506 | 1.0000000 | 0.846 | NA | NA |
| STAT3 | gefitinib | 0.8533074 | 1.0000000 | 0.853 | NA | NA |
| MGMT | gefitinib | 0.8596838 | 1.0000000 | 0.860 | NA | NA |
| BCOR | gefitinib | 0.8645140 | 1.0000000 | 0.865 | NA | NA |
| WHSC1 | gefitinib | 0.8743671 | 1.0000000 | 0.874 | NA | NA |
| JAK3 | gefitinib | 0.8850299 | 1.0000000 | 0.885 | NA | NA |
| PML | gefitinib | 0.8913918 | 1.0000000 | 0.891 | NA | NA |
| CDKN2A | gefitinib | 0.8936627 | 1.0000000 | 0.894 | NA | NA |
| CREBBP | gefitinib | 0.9009176 | 1.0000000 | 0.901 | NA | NA |
| PTEN | gefitinib | 0.9059535 | 1.0000000 | 0.906 | NA | NA |
| MET | gefitinib | 0.9240541 | 1.0000000 | 0.924 | NA | NA |
| PTCH1 | gefitinib | 0.9248583 | 1.0000000 | 0.925 | NA | NA |
| ROS1 | gefitinib | 0.9280030 | 1.0000000 | 0.928 | NA | NA |
| CBLB | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ATM | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PDGFRA | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CALR | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NPM1 | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NT5C2 | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| UGT1A1 | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PIGA | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| JAK2 | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| HRAS | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CTLA4 | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT2 | gefitinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NT5C2 | rucaparib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| ROS1 | rucaparib | 0.4953461 | 1.0000000 | 0.495 | NA | NA |
| ERBB4 | rucaparib | 0.5002518 | 1.0000000 | 0.500 | NA | NA |
| MET | rucaparib | 0.5002799 | 1.0000000 | 0.500 | NA | NA |
| BRAF | rucaparib | 0.5138566 | 1.0000000 | 0.514 | NA | NA |
| NRAS | rucaparib | 0.5337384 | 1.0000000 | 0.534 | NA | NA |
| MYCN | rucaparib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| VHL | rucaparib | 0.5565355 | 1.0000000 | 0.557 | NA | NA |
| WT1 | rucaparib | 0.5671762 | 1.0000000 | 0.567 | NA | NA |
| GATA3 | rucaparib | 0.5735551 | 1.0000000 | 0.574 | NA | NA |
| PDGFRA | rucaparib | 0.5800116 | 1.0000000 | 0.580 | NA | NA |
| PRPF8 | rucaparib | 0.5937641 | 1.0000000 | 0.594 | NA | NA |
| G6PD | rucaparib | 0.5958831 | 1.0000000 | 0.596 | NA | NA |
| EZH2 | rucaparib | 0.6229261 | 1.0000000 | 0.623 | NA | NA |
| MPL | rucaparib | 0.6352563 | 1.0000000 | 0.635 | NA | NA |
| PIGA | rucaparib | 0.6373519 | 1.0000000 | 0.637 | NA | NA |
| FGFR2 | rucaparib | 0.6592430 | 1.0000000 | 0.659 | NA | NA |
| KMT2A | rucaparib | 0.6608098 | 1.0000000 | 0.661 | NA | NA |
| SMC1A | rucaparib | 0.6650055 | 1.0000000 | 0.665 | NA | NA |
| SF3B1 | rucaparib | 0.6684229 | 1.0000000 | 0.668 | NA | NA |
| IL7R | rucaparib | 0.6719999 | 1.0000000 | 0.672 | NA | NA |
| ERBB2 | rucaparib | 0.6884976 | 1.0000000 | 0.688 | NA | NA |
| ATM | rucaparib | 0.6947785 | 1.0000000 | 0.695 | NA | NA |
| ERBB3 | rucaparib | 0.7093196 | 1.0000000 | 0.709 | NA | NA |
| WHSC1 | rucaparib | 0.7256055 | 1.0000000 | 0.726 | NA | NA |
| SETBP1 | rucaparib | 0.7363107 | 1.0000000 | 0.736 | NA | NA |
| PAX8 | rucaparib | 0.7491191 | 1.0000000 | 0.749 | NA | NA |
| KRAS | rucaparib | 0.7613129 | 1.0000000 | 0.761 | NA | NA |
| DDIT3 | rucaparib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| XPO1 | rucaparib | 0.7989067 | 1.0000000 | 0.799 | NA | NA |
| CBLB | rucaparib | 0.7998461 | 1.0000000 | 0.800 | NA | NA |
| TET2 | rucaparib | 0.8098941 | 1.0000000 | 0.810 | NA | NA |
| CALR | rucaparib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| EGFR | rucaparib | 0.8186882 | 1.0000000 | 0.819 | NA | NA |
| FGFR3 | rucaparib | 0.8228454 | 1.0000000 | 0.823 | NA | NA |
| BRCA2 | rucaparib | 0.8323233 | 1.0000000 | 0.832 | NA | NA |
| PIK3CA | rucaparib | 0.8403422 | 1.0000000 | 0.840 | NA | NA |
| NOTCH1 | rucaparib | 0.8463472 | 1.0000000 | 0.846 | NA | NA |
| HRAS | rucaparib | 0.8464506 | 1.0000000 | 0.846 | NA | NA |
| CREBBP | rucaparib | 0.8947233 | 1.0000000 | 0.895 | NA | NA |
| JAK3 | rucaparib | 0.8996189 | 1.0000000 | 0.900 | NA | NA |
| ASXL1 | rucaparib | 0.9115132 | 1.0000000 | 0.912 | NA | NA |
| SMC3 | rucaparib | 0.9180546 | 1.0000000 | 0.918 | NA | NA |
| TSC1 | rucaparib | 0.9271846 | 1.0000000 | 0.927 | NA | NA |
| ALK | rucaparib | 0.9287719 | 1.0000000 | 0.929 | NA | NA |
| UGT1A1 | rucaparib | 0.9320871 | 1.0000000 | 0.932 | NA | NA |
| PRPF40B | rucaparib | 0.9324613 | 1.0000000 | 0.932 | NA | NA |
| SH2B3 | rucaparib | 0.9361863 | 1.0000000 | 0.936 | NA | NA |
| ESR1 | rucaparib | 0.9385029 | 1.0000000 | 0.939 | NA | NA |
| BRCA1 | rucaparib | 0.9589731 | 1.0000000 | 0.959 | NA | NA |
| JAK1 | rucaparib | 0.9598565 | 1.0000000 | 0.960 | NA | NA |
| FLT3 | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PAX5 | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CTNNB1 | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT3 | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CRLF2 | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MYD88 | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA1 | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CD79B | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CTLA4 | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SRSF2 | rucaparib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB2 | belinostat | 0.0359196 | 1.0000000 | 0.036 |
|
NA |
| TP53 | belinostat | 0.0495767 | 1.0000000 | 0.050 |
|
NA |
| DNMT3A | belinostat | 0.0500164 | 1.0000000 | 0.050 | NA | NA |
| IL7R | belinostat | 0.0580240 | 1.0000000 | 0.058 | NA | NA |
| PTEN | belinostat | 0.0791666 | 1.0000000 | 0.079 | NA | NA |
| CSF3R | belinostat | 0.0922923 | 1.0000000 | 0.092 | NA | NA |
| SF3B1 | belinostat | 0.1015512 | 1.0000000 | 0.102 | NA | NA |
| NPM1 | belinostat | 0.1051925 | 1.0000000 | 0.105 | NA | NA |
| EML4 | belinostat | 0.1173639 | 1.0000000 | 0.117 | NA | NA |
| ROS1 | belinostat | 0.1189430 | 1.0000000 | 0.119 | NA | NA |
| SMO | belinostat | 0.1259398 | 1.0000000 | 0.126 | NA | NA |
| MPL | belinostat | 0.1637344 | 1.0000000 | 0.164 | NA | NA |
| AKT2 | belinostat | 0.1752442 | 1.0000000 | 0.175 | NA | NA |
| CBL | belinostat | 0.1752442 | 1.0000000 | 0.175 | NA | NA |
| GATA3 | belinostat | 0.1936528 | 1.0000000 | 0.194 | NA | NA |
| CXCR4 | belinostat | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| DNAJB1 | belinostat | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| TSC1 | belinostat | 0.2284617 | 1.0000000 | 0.228 | NA | NA |
| RAD21 | belinostat | 0.2356447 | 1.0000000 | 0.236 | NA | NA |
| PAX8 | belinostat | 0.2409547 | 1.0000000 | 0.241 | NA | NA |
| MYD88 | belinostat | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| JAK3 | belinostat | 0.2521142 | 1.0000000 | 0.252 | NA | NA |
| ESR1 | belinostat | 0.2615722 | 1.0000000 | 0.262 | NA | NA |
| TET2 | belinostat | 0.2870148 | 1.0000000 | 0.287 | NA | NA |
| HRAS | belinostat | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| AR | belinostat | 0.2913240 | 1.0000000 | 0.291 | NA | NA |
| XPO1 | belinostat | 0.2986177 | 1.0000000 | 0.299 | NA | NA |
| PTCH1 | belinostat | 0.3220200 | 1.0000000 | 0.322 | NA | NA |
| CDKN2A | belinostat | 0.3373325 | 1.0000000 | 0.337 | NA | NA |
| JAK1 | belinostat | 0.3389006 | 1.0000000 | 0.339 | NA | NA |
| NCOA2 | belinostat | 0.3637223 | 1.0000000 | 0.364 | NA | NA |
| FGFR3 | belinostat | 0.3640864 | 1.0000000 | 0.364 | NA | NA |
| SETBP1 | belinostat | 0.3670945 | 1.0000000 | 0.367 | NA | NA |
| WT1 | belinostat | 0.3709136 | 1.0000000 | 0.371 | NA | NA |
| FLT3 | belinostat | 0.3709752 | 1.0000000 | 0.371 | NA | NA |
| GATA1 | belinostat | 0.3777807 | 1.0000000 | 0.378 | NA | NA |
| NT5C2 | belinostat | 0.3864762 | 1.0000000 | 0.386 | NA | NA |
| EGFR | belinostat | 0.3930147 | 1.0000000 | 0.393 | NA | NA |
| WHSC1 | belinostat | 0.3987861 | 1.0000000 | 0.399 | NA | NA |
| BRAF | belinostat | 0.4241885 | 1.0000000 | 0.424 | NA | NA |
| ASXL1 | belinostat | 0.4271624 | 1.0000000 | 0.427 | NA | NA |
| PML | belinostat | 0.4445821 | 1.0000000 | 0.445 | NA | NA |
| STAT3 | belinostat | 0.4468728 | 1.0000000 | 0.447 | NA | NA |
| CTCF | belinostat | 0.4562551 | 1.0000000 | 0.456 | NA | NA |
| STAG2 | belinostat | 0.4567504 | 1.0000000 | 0.457 | NA | NA |
| PDGFRA | belinostat | 0.4698549 | 1.0000000 | 0.470 | NA | NA |
| CALR | belinostat | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| CRLF2 | belinostat | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| GNA11 | belinostat | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| EGF | belinostat | 0.4900103 | 1.0000000 | 0.490 | NA | NA |
| SMC3 | belinostat | 0.5036550 | 1.0000000 | 0.504 | NA | NA |
| CREBBP | belinostat | 0.5058991 | 1.0000000 | 0.506 | NA | NA |
| JAK2 | belinostat | 0.5261475 | 1.0000000 | 0.526 | NA | NA |
| KIT | belinostat | 0.5329271 | 1.0000000 | 0.533 | NA | NA |
| MGMT | belinostat | 0.5509850 | 1.0000000 | 0.551 | NA | NA |
| MAP2K1 | belinostat | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| SMC1A | belinostat | 0.5958831 | 1.0000000 | 0.596 | NA | NA |
| VHL | belinostat | 0.6004018 | 1.0000000 | 0.600 | NA | NA |
| KMT2A | belinostat | 0.6155746 | 1.0000000 | 0.616 | NA | NA |
| PRPF8 | belinostat | 0.6169206 | 1.0000000 | 0.617 | NA | NA |
| AKT1 | belinostat | 0.6227533 | 1.0000000 | 0.623 | NA | NA |
| ATM | belinostat | 0.6261757 | 1.0000000 | 0.626 | NA | NA |
| RUNX1 | belinostat | 0.6352563 | 1.0000000 | 0.635 | NA | NA |
| BTK | belinostat | 0.6366016 | 1.0000000 | 0.637 | NA | NA |
| TSC2 | belinostat | 0.6411217 | 1.0000000 | 0.641 | NA | NA |
| ERBB3 | belinostat | 0.6439862 | 1.0000000 | 0.644 | NA | NA |
| IDH1 | belinostat | 0.6605492 | 1.0000000 | 0.661 | NA | NA |
| CD79B | belinostat | 0.6625206 | 1.0000000 | 0.663 | NA | NA |
| ABL1 | belinostat | 0.6851355 | 1.0000000 | 0.685 | NA | NA |
| IKZF1 | belinostat | 0.6950398 | 1.0000000 | 0.695 | NA | NA |
| GNB1 | belinostat | 0.6985354 | 1.0000000 | 0.699 | NA | NA |
| CTLA4 | belinostat | 0.6985354 | 1.0000000 | 0.699 | NA | NA |
| SETD2 | belinostat | 0.7241276 | 1.0000000 | 0.724 | NA | NA |
| CDK4 | belinostat | 0.7373721 | 1.0000000 | 0.737 | NA | NA |
| NOTCH1 | belinostat | 0.7426322 | 1.0000000 | 0.743 | NA | NA |
| SRSF2 | belinostat | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| ETV6 | belinostat | 0.7998461 | 1.0000000 | 0.800 | NA | NA |
| FBXW7 | belinostat | 0.8017632 | 1.0000000 | 0.802 | NA | NA |
| PAX5 | belinostat | 0.8197075 | 1.0000000 | 0.820 | NA | NA |
| GNAS | belinostat | 0.8261742 | 1.0000000 | 0.826 | NA | NA |
| PRPF40B | belinostat | 0.8296028 | 1.0000000 | 0.830 | NA | NA |
| MYCN | belinostat | 0.8345316 | 1.0000000 | 0.835 | NA | NA |
| KRAS | belinostat | 0.8425079 | 1.0000000 | 0.843 | NA | NA |
| ERBB4 | belinostat | 0.8468497 | 1.0000000 | 0.847 | NA | NA |
| MET | belinostat | 0.8488272 | 1.0000000 | 0.849 | NA | NA |
| FGFR2 | belinostat | 0.8501067 | 1.0000000 | 0.850 | NA | NA |
| CBLB | belinostat | 0.8533074 | 1.0000000 | 0.853 | NA | NA |
| RET | belinostat | 0.8743671 | 1.0000000 | 0.874 | NA | NA |
| SF1 | belinostat | 0.8972790 | 1.0000000 | 0.897 | NA | NA |
| NOTCH2 | belinostat | 0.9024811 | 1.0000000 | 0.902 | NA | NA |
| BRCA2 | belinostat | 0.9053952 | 1.0000000 | 0.905 | NA | NA |
| UGT1A1 | belinostat | 0.9145888 | 1.0000000 | 0.915 | NA | NA |
| ALK | belinostat | 0.9249291 | 1.0000000 | 0.925 | NA | NA |
| EZH2 | belinostat | 0.9470426 | 1.0000000 | 0.947 | NA | NA |
| BRCA1 | belinostat | 0.9548441 | 1.0000000 | 0.955 | NA | NA |
| PDGFRB | belinostat | 0.9589731 | 1.0000000 | 0.959 | NA | NA |
| BCORL1 | belinostat | 0.9702715 | 1.0000000 | 0.970 | NA | NA |
| DPYD | belinostat | 0.9746104 | 1.0000000 | 0.975 | NA | NA |
| BCOR | belinostat | 0.9767628 | 1.0000000 | 0.977 | NA | NA |
| IDH2 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CTNNB1 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NRAS | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT3 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA2 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FGFR1 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SSX1 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PDGFB | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SH2B3 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| G6PD | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| DDIT3 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ZRSR2 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CDK6 | belinostat | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ATM | dabrafenib | 0.8627519 | 1.0000000 | 0.863 | NA | NA |
| AKT1 | dabrafenib | 0.8807910 | 1.0000000 | 0.881 | NA | NA |
| PDGFRA | dabrafenib | 0.9036365 | 1.0000000 | 0.904 | NA | NA |
| VHL | dabrafenib | 0.9089940 | 1.0000000 | 0.909 | NA | NA |
| TSC1 | dabrafenib | 0.9271846 | 1.0000000 | 0.927 | NA | NA |
| FGFR2 | dabrafenib | 0.9272645 | 1.0000000 | 0.927 | NA | NA |
| FGFR3 | dabrafenib | 0.9300799 | 1.0000000 | 0.930 | NA | NA |
| IKZF1 | dabrafenib | 0.9378793 | 1.0000000 | 0.938 | NA | NA |
| NRAS | dabrafenib | 0.9407729 | 1.0000000 | 0.941 | NA | NA |
| IDH2 | dabrafenib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CALR | dabrafenib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BCOR | dabrafenib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FBXW7 | dabrafenib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BTK | dabrafenib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PIGA | dabrafenib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MPL | dabrafenib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| KIT | dabrafenib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB3 | palbociclib | 0.0128240 | 1.0000000 | 0.013 |
|
NA |
| SMO | palbociclib | 0.0450696 | 1.0000000 | 0.045 |
|
NA |
| ALK | palbociclib | 0.0553726 | 1.0000000 | 0.055 | NA | NA |
| VHL | palbociclib | 0.0695285 | 1.0000000 | 0.070 | NA | NA |
| NCOA2 | palbociclib | 0.0750492 | 1.0000000 | 0.075 | NA | NA |
| CREBBP | palbociclib | 0.0836029 | 1.0000000 | 0.084 | NA | NA |
| STAG2 | palbociclib | 0.0954832 | 1.0000000 | 0.095 | NA | NA |
| MGMT | palbociclib | 0.1051925 | 1.0000000 | 0.105 | NA | NA |
| BTK | palbociclib | 0.1098194 | 1.0000000 | 0.110 | NA | NA |
| SRSF2 | palbociclib | 0.1489147 | 1.0000000 | 0.149 | NA | NA |
| GNB1 | palbociclib | 0.1876828 | 1.0000000 | 0.188 | NA | NA |
| SMC1A | palbociclib | 0.1939309 | 1.0000000 | 0.194 | NA | NA |
| CBLB | palbociclib | 0.1955617 | 1.0000000 | 0.196 | NA | NA |
| CBL | palbociclib | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| BRAF | palbociclib | 0.2246703 | 1.0000000 | 0.225 | NA | NA |
| SF3B1 | palbociclib | 0.2315445 | 1.0000000 | 0.232 | NA | NA |
| SMC3 | palbociclib | 0.2438864 | 1.0000000 | 0.244 | NA | NA |
| NT5C2 | palbociclib | 0.2471600 | 1.0000000 | 0.247 | NA | NA |
| BRCA2 | palbociclib | 0.2502301 | 1.0000000 | 0.250 | NA | NA |
| TET2 | palbociclib | 0.2550452 | 1.0000000 | 0.255 | NA | NA |
| IL7R | palbociclib | 0.2818036 | 1.0000000 | 0.282 | NA | NA |
| JAK1 | palbociclib | 0.2840336 | 1.0000000 | 0.284 | NA | NA |
| EZH2 | palbociclib | 0.2976215 | 1.0000000 | 0.298 | NA | NA |
| BCOR | palbociclib | 0.2986177 | 1.0000000 | 0.299 | NA | NA |
| FGFR1 | palbociclib | 0.3052255 | 1.0000000 | 0.305 | NA | NA |
| IKZF1 | palbociclib | 0.3216665 | 1.0000000 | 0.322 | NA | NA |
| BCORL1 | palbociclib | 0.3319586 | 1.0000000 | 0.332 | NA | NA |
| EGFR | palbociclib | 0.3371061 | 1.0000000 | 0.337 | NA | NA |
| RET | palbociclib | 0.3502014 | 1.0000000 | 0.350 | NA | NA |
| STAT3 | palbociclib | 0.3525421 | 1.0000000 | 0.353 | NA | NA |
| ZRSR2 | palbociclib | 0.3593968 | 1.0000000 | 0.359 | NA | NA |
| IDH2 | palbociclib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| MAP2K1 | palbociclib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| CRLF2 | palbociclib | 0.3864762 | 1.0000000 | 0.386 | NA | NA |
| GATA2 | palbociclib | 0.3950916 | 1.0000000 | 0.395 | NA | NA |
| ROS1 | palbociclib | 0.4125285 | 1.0000000 | 0.413 | NA | NA |
| PIK3CA | palbociclib | 0.4220345 | 1.0000000 | 0.422 | NA | NA |
| CSF3R | palbociclib | 0.4366766 | 1.0000000 | 0.437 | NA | NA |
| CXCR4 | palbociclib | 0.4532547 | 1.0000000 | 0.453 | NA | NA |
| FGFR3 | palbociclib | 0.4577319 | 1.0000000 | 0.458 | NA | NA |
| DNMT3A | palbociclib | 0.4735404 | 1.0000000 | 0.474 | NA | NA |
| AKT3 | palbociclib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| CD79B | palbociclib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| TSC2 | palbociclib | 0.4882430 | 1.0000000 | 0.488 | NA | NA |
| PTCH1 | palbociclib | 0.4898114 | 1.0000000 | 0.490 | NA | NA |
| FGFR2 | palbociclib | 0.5334165 | 1.0000000 | 0.533 | NA | NA |
| SH2B3 | palbociclib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| CTLA4 | palbociclib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| SSX1 | palbociclib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| TP53 | palbociclib | 0.5418333 | 1.0000000 | 0.542 | NA | NA |
| SETBP1 | palbociclib | 0.5439054 | 1.0000000 | 0.544 | NA | NA |
| MET | palbociclib | 0.5473180 | 1.0000000 | 0.547 | NA | NA |
| MYD88 | palbociclib | 0.5581846 | 1.0000000 | 0.558 | NA | NA |
| KRAS | palbociclib | 0.5595746 | 1.0000000 | 0.560 | NA | NA |
| AKT2 | palbociclib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| EML4 | palbociclib | 0.6140775 | 1.0000000 | 0.614 | NA | NA |
| ASXL1 | palbociclib | 0.6277256 | 1.0000000 | 0.628 | NA | NA |
| AR | palbociclib | 0.6341948 | 1.0000000 | 0.634 | NA | NA |
| PIGA | palbociclib | 0.6373519 | 1.0000000 | 0.637 | NA | NA |
| KIT | palbociclib | 0.6403709 | 1.0000000 | 0.640 | NA | NA |
| FLT3 | palbociclib | 0.6439862 | 1.0000000 | 0.644 | NA | NA |
| PDGFRA | palbociclib | 0.6439862 | 1.0000000 | 0.644 | NA | NA |
| TSC1 | palbociclib | 0.6477157 | 1.0000000 | 0.648 | NA | NA |
| NOTCH2 | palbociclib | 0.6580726 | 1.0000000 | 0.658 | NA | NA |
| IDH1 | palbociclib | 0.6625206 | 1.0000000 | 0.663 | NA | NA |
| MPL | palbociclib | 0.6625206 | 1.0000000 | 0.663 | NA | NA |
| GNAS | palbociclib | 0.6696433 | 1.0000000 | 0.670 | NA | NA |
| ETV6 | palbociclib | 0.6711255 | 1.0000000 | 0.671 | NA | NA |
| EGF | palbociclib | 0.6712469 | 1.0000000 | 0.671 | NA | NA |
| FBXW7 | palbociclib | 0.6872879 | 1.0000000 | 0.687 | NA | NA |
| WHSC1 | palbociclib | 0.6933660 | 1.0000000 | 0.693 | NA | NA |
| ESR1 | palbociclib | 0.6952986 | 1.0000000 | 0.695 | NA | NA |
| MYCN | palbociclib | 0.7133032 | 1.0000000 | 0.713 | NA | NA |
| CDKN2A | palbociclib | 0.7220822 | 1.0000000 | 0.722 | NA | NA |
| HRAS | palbociclib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| UGT1A1 | palbociclib | 0.7316568 | 1.0000000 | 0.732 | NA | NA |
| JAK3 | palbociclib | 0.7346140 | 1.0000000 | 0.735 | NA | NA |
| GATA1 | palbociclib | 0.7373721 | 1.0000000 | 0.737 | NA | NA |
| PAX8 | palbociclib | 0.7655945 | 1.0000000 | 0.766 | NA | NA |
| ATM | palbociclib | 0.7670996 | 1.0000000 | 0.767 | NA | NA |
| ABL1 | palbociclib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| NOTCH1 | palbociclib | 0.7868350 | 1.0000000 | 0.787 | NA | NA |
| SETD2 | palbociclib | 0.7869801 | 1.0000000 | 0.787 | NA | NA |
| PDGFRB | palbociclib | 0.7963888 | 1.0000000 | 0.796 | NA | NA |
| CTNNB1 | palbociclib | 0.8119822 | 1.0000000 | 0.812 | NA | NA |
| BRCA1 | palbociclib | 0.8157105 | 1.0000000 | 0.816 | NA | NA |
| CALR | palbociclib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| GATA3 | palbociclib | 0.8316391 | 1.0000000 | 0.832 | NA | NA |
| ERBB4 | palbociclib | 0.8438380 | 1.0000000 | 0.844 | NA | NA |
| PAX5 | palbociclib | 0.8464506 | 1.0000000 | 0.846 | NA | NA |
| GNA11 | palbociclib | 0.8464506 | 1.0000000 | 0.846 | NA | NA |
| ERBB2 | palbociclib | 0.8588936 | 1.0000000 | 0.859 | NA | NA |
| G6PD | palbociclib | 0.8596838 | 1.0000000 | 0.860 | NA | NA |
| PRPF40B | palbociclib | 0.8768661 | 1.0000000 | 0.877 | NA | NA |
| PRPF8 | palbociclib | 0.8929799 | 1.0000000 | 0.893 | NA | NA |
| DPYD | palbociclib | 0.9069783 | 1.0000000 | 0.907 | NA | NA |
| WT1 | palbociclib | 0.9351699 | 1.0000000 | 0.935 | NA | NA |
| CTCF | palbociclib | 0.9366772 | 1.0000000 | 0.937 | NA | NA |
| PTEN | palbociclib | 0.9528947 | 1.0000000 | 0.953 | NA | NA |
| KMT2A | palbociclib | 0.9634074 | 1.0000000 | 0.963 | NA | NA |
| PML | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NPM1 | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NRAS | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| RAD21 | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| XPO1 | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SF1 | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CDK4 | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| DDIT3 | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| JAK2 | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT1 | palbociclib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMC1A | alectinib | 0.8852339 | 1.0000000 | 0.885 | NA | NA |
| PDGFRA | alectinib | 0.9118752 | 1.0000000 | 0.912 | NA | NA |
| KRAS | alectinib | 0.9166007 | 1.0000000 | 0.917 | NA | NA |
| NOTCH1 | alectinib | 0.9188042 | 1.0000000 | 0.919 | NA | NA |
| ALK | alectinib | 0.9194853 | 1.0000000 | 0.919 | NA | NA |
| SF3B1 | alectinib | 0.9201477 | 1.0000000 | 0.920 | NA | NA |
| PRPF8 | alectinib | 0.9203095 | 1.0000000 | 0.920 | NA | NA |
| SMO | alectinib | 0.9213966 | 1.0000000 | 0.921 | NA | NA |
| MYCN | alectinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MAP2K1 | alectinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FGFR2 | alectinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA1 | alectinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PDGFB | alectinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NCOA2 | alectinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PAX8 | alectinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CXCR4 | alectinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ZRSR2 | alectinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| IL7R | afatinib | 0.0140193 | 1.0000000 | 0.014 |
|
NA |
| PDGFRB | afatinib | 0.0323905 | 1.0000000 | 0.032 |
|
NA |
| JAK1 | afatinib | 0.0375635 | 1.0000000 | 0.038 |
|
NA |
| MYCN | afatinib | 0.0661926 | 1.0000000 | 0.066 | NA | NA |
| EML4 | afatinib | 0.0691324 | 1.0000000 | 0.069 | NA | NA |
| PAX5 | afatinib | 0.0813611 | 1.0000000 | 0.081 | NA | NA |
| BCORL1 | afatinib | 0.1295247 | 1.0000000 | 0.130 | NA | NA |
| GATA3 | afatinib | 0.1325535 | 1.0000000 | 0.133 | NA | NA |
| SF1 | afatinib | 0.1360371 | 1.0000000 | 0.136 | NA | NA |
| ABL1 | afatinib | 0.1392493 | 1.0000000 | 0.139 | NA | NA |
| TP53 | afatinib | 0.1403919 | 1.0000000 | 0.140 | NA | NA |
| PTCH1 | afatinib | 0.1571458 | 1.0000000 | 0.157 | NA | NA |
| TSC2 | afatinib | 0.1686855 | 1.0000000 | 0.169 | NA | NA |
| PTEN | afatinib | 0.1742555 | 1.0000000 | 0.174 | NA | NA |
| BRCA1 | afatinib | 0.1778153 | 1.0000000 | 0.178 | NA | NA |
| ATM | afatinib | 0.1897456 | 1.0000000 | 0.190 | NA | NA |
| EGF | afatinib | 0.1928758 | 1.0000000 | 0.193 | NA | NA |
| PRPF40B | afatinib | 0.2015990 | 1.0000000 | 0.202 | NA | NA |
| FGFR3 | afatinib | 0.2045509 | 1.0000000 | 0.205 | NA | NA |
| CBL | afatinib | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| CSF3R | afatinib | 0.2293319 | 1.0000000 | 0.229 | NA | NA |
| GATA1 | afatinib | 0.2410324 | 1.0000000 | 0.241 | NA | NA |
| MYD88 | afatinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| PDGFB | afatinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| AKT2 | afatinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| ERBB2 | afatinib | 0.2704472 | 1.0000000 | 0.270 | NA | NA |
| EZH2 | afatinib | 0.2780757 | 1.0000000 | 0.278 | NA | NA |
| HRAS | afatinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| BTK | afatinib | 0.2986177 | 1.0000000 | 0.299 | NA | NA |
| ERBB4 | afatinib | 0.2986380 | 1.0000000 | 0.299 | NA | NA |
| SETD2 | afatinib | 0.3079003 | 1.0000000 | 0.308 | NA | NA |
| RAD21 | afatinib | 0.3230126 | 1.0000000 | 0.323 | NA | NA |
| AR | afatinib | 0.3412685 | 1.0000000 | 0.341 | NA | NA |
| RET | afatinib | 0.3463248 | 1.0000000 | 0.346 | NA | NA |
| CBLB | afatinib | 0.3525421 | 1.0000000 | 0.353 | NA | NA |
| ZRSR2 | afatinib | 0.3593968 | 1.0000000 | 0.359 | NA | NA |
| XPO1 | afatinib | 0.3619348 | 1.0000000 | 0.362 | NA | NA |
| IDH2 | afatinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| NRAS | afatinib | 0.3748016 | 1.0000000 | 0.375 | NA | NA |
| UGT1A1 | afatinib | 0.3777807 | 1.0000000 | 0.378 | NA | NA |
| SETBP1 | afatinib | 0.3784295 | 1.0000000 | 0.378 | NA | NA |
| FLT3 | afatinib | 0.4148455 | 1.0000000 | 0.415 | NA | NA |
| GATA2 | afatinib | 0.4167928 | 1.0000000 | 0.417 | NA | NA |
| NOTCH2 | afatinib | 0.4257818 | 1.0000000 | 0.426 | NA | NA |
| CDK4 | afatinib | 0.4344457 | 1.0000000 | 0.434 | NA | NA |
| JAK2 | afatinib | 0.4366607 | 1.0000000 | 0.437 | NA | NA |
| VHL | afatinib | 0.4533555 | 1.0000000 | 0.453 | NA | NA |
| STAT3 | afatinib | 0.4595426 | 1.0000000 | 0.460 | NA | NA |
| CTNNB1 | afatinib | 0.4658564 | 1.0000000 | 0.466 | NA | NA |
| ASXL1 | afatinib | 0.4824052 | 1.0000000 | 0.482 | NA | NA |
| SH2B3 | afatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| CTLA4 | afatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| SF3B1 | afatinib | 0.5540232 | 1.0000000 | 0.554 | NA | NA |
| SMC3 | afatinib | 0.5601197 | 1.0000000 | 0.560 | NA | NA |
| MAP2K1 | afatinib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| WT1 | afatinib | 0.5690882 | 1.0000000 | 0.569 | NA | NA |
| ESR1 | afatinib | 0.5790997 | 1.0000000 | 0.579 | NA | NA |
| MGMT | afatinib | 0.5958831 | 1.0000000 | 0.596 | NA | NA |
| EGFR | afatinib | 0.6119104 | 1.0000000 | 0.612 | NA | NA |
| GNAS | afatinib | 0.6172651 | 1.0000000 | 0.617 | NA | NA |
| BRCA2 | afatinib | 0.6352378 | 1.0000000 | 0.635 | NA | NA |
| KRAS | afatinib | 0.6429328 | 1.0000000 | 0.643 | NA | NA |
| MPL | afatinib | 0.6625206 | 1.0000000 | 0.663 | NA | NA |
| TSC1 | afatinib | 0.6708487 | 1.0000000 | 0.671 | NA | NA |
| IKZF1 | afatinib | 0.6710327 | 1.0000000 | 0.671 | NA | NA |
| CTCF | afatinib | 0.7092180 | 1.0000000 | 0.709 | NA | NA |
| AKT1 | afatinib | 0.7212767 | 1.0000000 | 0.721 | NA | NA |
| MET | afatinib | 0.7266861 | 1.0000000 | 0.727 | NA | NA |
| NCOA2 | afatinib | 0.7288260 | 1.0000000 | 0.729 | NA | NA |
| FGFR1 | afatinib | 0.7331961 | 1.0000000 | 0.733 | NA | NA |
| ERBB3 | afatinib | 0.7411004 | 1.0000000 | 0.741 | NA | NA |
| NOTCH1 | afatinib | 0.7593922 | 1.0000000 | 0.759 | NA | NA |
| PAX8 | afatinib | 0.7655945 | 1.0000000 | 0.766 | NA | NA |
| NPM1 | afatinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| G6PD | afatinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| DDIT3 | afatinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| SRSF2 | afatinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| ETV6 | afatinib | 0.7768140 | 1.0000000 | 0.777 | NA | NA |
| KMT2A | afatinib | 0.7780324 | 1.0000000 | 0.778 | NA | NA |
| FGFR2 | afatinib | 0.7841912 | 1.0000000 | 0.784 | NA | NA |
| PRPF8 | afatinib | 0.7878765 | 1.0000000 | 0.788 | NA | NA |
| WHSC1 | afatinib | 0.7921474 | 1.0000000 | 0.792 | NA | NA |
| DNMT3A | afatinib | 0.7983763 | 1.0000000 | 0.798 | NA | NA |
| CXCR4 | afatinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| AKT3 | afatinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| NT5C2 | afatinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| STAG2 | afatinib | 0.8230633 | 1.0000000 | 0.823 | NA | NA |
| PIK3CA | afatinib | 0.8326621 | 1.0000000 | 0.833 | NA | NA |
| PML | afatinib | 0.8377167 | 1.0000000 | 0.838 | NA | NA |
| GNA11 | afatinib | 0.8464506 | 1.0000000 | 0.846 | NA | NA |
| ROS1 | afatinib | 0.8610109 | 1.0000000 | 0.861 | NA | NA |
| GNB1 | afatinib | 0.8836175 | 1.0000000 | 0.884 | NA | NA |
| FBXW7 | afatinib | 0.8857596 | 1.0000000 | 0.886 | NA | NA |
| DPYD | afatinib | 0.9118987 | 1.0000000 | 0.912 | NA | NA |
| BCOR | afatinib | 0.9184562 | 1.0000000 | 0.918 | NA | NA |
| CREBBP | afatinib | 0.9228574 | 1.0000000 | 0.923 | NA | NA |
| PDGFRA | afatinib | 0.9405696 | 1.0000000 | 0.941 | NA | NA |
| ALK | afatinib | 0.9529231 | 1.0000000 | 0.953 | NA | NA |
| BRAF | afatinib | 0.9869873 | 1.0000000 | 0.987 | NA | NA |
| TET2 | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CALR | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CDKN2A | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| IDH1 | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMO | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| KIT | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| JAK3 | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SSX1 | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CD79B | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PIGA | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CRLF2 | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMC1A | afatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FGFR3 | docetaxel | 0.0439066 | 1.0000000 | 0.044 |
|
NA |
| DNMT3A | docetaxel | 0.0610279 | 1.0000000 | 0.061 | NA | NA |
| MYCN | docetaxel | 0.0661926 | 1.0000000 | 0.066 | NA | NA |
| FGFR2 | docetaxel | 0.0828374 | 1.0000000 | 0.083 | NA | NA |
| PDGFRA | docetaxel | 0.0863925 | 1.0000000 | 0.086 | NA | NA |
| AKT3 | docetaxel | 0.1051925 | 1.0000000 | 0.105 | NA | NA |
| TSC2 | docetaxel | 0.1109870 | 1.0000000 | 0.111 | NA | NA |
| MGMT | docetaxel | 0.1116118 | 1.0000000 | 0.112 | NA | NA |
| KMT2A | docetaxel | 0.1173432 | 1.0000000 | 0.117 | NA | NA |
| PDGFRB | docetaxel | 0.1321661 | 1.0000000 | 0.132 | NA | NA |
| ROS1 | docetaxel | 0.1486063 | 1.0000000 | 0.149 | NA | NA |
| CRLF2 | docetaxel | 0.1489147 | 1.0000000 | 0.149 | NA | NA |
| GATA3 | docetaxel | 0.1696541 | 1.0000000 | 0.170 | NA | NA |
| SMO | docetaxel | 0.1703249 | 1.0000000 | 0.170 | NA | NA |
| PAX5 | docetaxel | 0.1752442 | 1.0000000 | 0.175 | NA | NA |
| EZH2 | docetaxel | 0.1930591 | 1.0000000 | 0.193 | NA | NA |
| IKZF1 | docetaxel | 0.2025950 | 1.0000000 | 0.203 | NA | NA |
| STAG2 | docetaxel | 0.2051177 | 1.0000000 | 0.205 | NA | NA |
| ZRSR2 | docetaxel | 0.2217000 | 1.0000000 | 0.222 | NA | NA |
| DPYD | docetaxel | 0.2529054 | 1.0000000 | 0.253 | NA | NA |
| WHSC1 | docetaxel | 0.2683816 | 1.0000000 | 0.268 | NA | NA |
| NOTCH1 | docetaxel | 0.2811908 | 1.0000000 | 0.281 | NA | NA |
| NOTCH2 | docetaxel | 0.2976500 | 1.0000000 | 0.298 | NA | NA |
| ETV6 | docetaxel | 0.2986177 | 1.0000000 | 0.299 | NA | NA |
| EML4 | docetaxel | 0.3126142 | 1.0000000 | 0.313 | NA | NA |
| XPO1 | docetaxel | 0.3619348 | 1.0000000 | 0.362 | NA | NA |
| CTNNB1 | docetaxel | 0.3658605 | 1.0000000 | 0.366 | NA | NA |
| IDH2 | docetaxel | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| SF1 | docetaxel | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| PTEN | docetaxel | 0.3755743 | 1.0000000 | 0.376 | NA | NA |
| UGT1A1 | docetaxel | 0.3777807 | 1.0000000 | 0.378 | NA | NA |
| BCORL1 | docetaxel | 0.3781105 | 1.0000000 | 0.378 | NA | NA |
| IDH1 | docetaxel | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| G6PD | docetaxel | 0.3864762 | 1.0000000 | 0.386 | NA | NA |
| DDIT3 | docetaxel | 0.3864762 | 1.0000000 | 0.386 | NA | NA |
| EGF | docetaxel | 0.3957657 | 1.0000000 | 0.396 | NA | NA |
| ABL1 | docetaxel | 0.4047291 | 1.0000000 | 0.405 | NA | NA |
| CTCF | docetaxel | 0.4119913 | 1.0000000 | 0.412 | NA | NA |
| FLT3 | docetaxel | 0.4148455 | 1.0000000 | 0.415 | NA | NA |
| RAD21 | docetaxel | 0.4291606 | 1.0000000 | 0.429 | NA | NA |
| CDK4 | docetaxel | 0.4344457 | 1.0000000 | 0.434 | NA | NA |
| CBLB | docetaxel | 0.4468728 | 1.0000000 | 0.447 | NA | NA |
| CBL | docetaxel | 0.4532547 | 1.0000000 | 0.453 | NA | NA |
| ESR1 | docetaxel | 0.4595426 | 1.0000000 | 0.460 | NA | NA |
| BRAF | docetaxel | 0.4831049 | 1.0000000 | 0.483 | NA | NA |
| CALR | docetaxel | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| NT5C2 | docetaxel | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| CD79B | docetaxel | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| BTK | docetaxel | 0.5083316 | 1.0000000 | 0.508 | NA | NA |
| NCOA2 | docetaxel | 0.5326028 | 1.0000000 | 0.533 | NA | NA |
| AR | docetaxel | 0.5406816 | 1.0000000 | 0.541 | NA | NA |
| SF3B1 | docetaxel | 0.5540232 | 1.0000000 | 0.554 | NA | NA |
| AKT2 | docetaxel | 0.5581846 | 1.0000000 | 0.558 | NA | NA |
| GNA11 | docetaxel | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| BCOR | docetaxel | 0.5618168 | 1.0000000 | 0.562 | NA | NA |
| IL7R | docetaxel | 0.5707504 | 1.0000000 | 0.571 | NA | NA |
| PIK3CA | docetaxel | 0.5827651 | 1.0000000 | 0.583 | NA | NA |
| TET2 | docetaxel | 0.5897916 | 1.0000000 | 0.590 | NA | NA |
| SMC1A | docetaxel | 0.5958831 | 1.0000000 | 0.596 | NA | NA |
| ERBB2 | docetaxel | 0.6212956 | 1.0000000 | 0.621 | NA | NA |
| ATM | docetaxel | 0.6294581 | 1.0000000 | 0.629 | NA | NA |
| PTCH1 | docetaxel | 0.6372275 | 1.0000000 | 0.637 | NA | NA |
| VHL | docetaxel | 0.6527828 | 1.0000000 | 0.653 | NA | NA |
| MPL | docetaxel | 0.6625206 | 1.0000000 | 0.663 | NA | NA |
| JAK3 | docetaxel | 0.6644424 | 1.0000000 | 0.664 | NA | NA |
| TSC1 | docetaxel | 0.6708487 | 1.0000000 | 0.671 | NA | NA |
| KIT | docetaxel | 0.6710327 | 1.0000000 | 0.671 | NA | NA |
| ERBB4 | docetaxel | 0.6860694 | 1.0000000 | 0.686 | NA | NA |
| RET | docetaxel | 0.6865042 | 1.0000000 | 0.687 | NA | NA |
| CREBBP | docetaxel | 0.6882920 | 1.0000000 | 0.688 | NA | NA |
| GATA1 | docetaxel | 0.6959426 | 1.0000000 | 0.696 | NA | NA |
| JAK2 | docetaxel | 0.6973337 | 1.0000000 | 0.697 | NA | NA |
| GNAS | docetaxel | 0.7040976 | 1.0000000 | 0.704 | NA | NA |
| HRAS | docetaxel | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| FGFR1 | docetaxel | 0.7331961 | 1.0000000 | 0.733 | NA | NA |
| SETD2 | docetaxel | 0.7339475 | 1.0000000 | 0.734 | NA | NA |
| FBXW7 | docetaxel | 0.7374484 | 1.0000000 | 0.737 | NA | NA |
| PAX8 | docetaxel | 0.7655945 | 1.0000000 | 0.766 | NA | NA |
| ALK | docetaxel | 0.7678547 | 1.0000000 | 0.768 | NA | NA |
| SRSF2 | docetaxel | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| PML | docetaxel | 0.7847867 | 1.0000000 | 0.785 | NA | NA |
| PRPF8 | docetaxel | 0.7878765 | 1.0000000 | 0.788 | NA | NA |
| CDKN2A | docetaxel | 0.7892058 | 1.0000000 | 0.789 | NA | NA |
| BRCA1 | docetaxel | 0.8064547 | 1.0000000 | 0.806 | NA | NA |
| SETBP1 | docetaxel | 0.8101625 | 1.0000000 | 0.810 | NA | NA |
| CSF3R | docetaxel | 0.8320040 | 1.0000000 | 0.832 | NA | NA |
| JAK1 | docetaxel | 0.8500510 | 1.0000000 | 0.850 | NA | NA |
| ASXL1 | docetaxel | 0.8882745 | 1.0000000 | 0.888 | NA | NA |
| EGFR | docetaxel | 0.8990693 | 1.0000000 | 0.899 | NA | NA |
| TP53 | docetaxel | 0.9183676 | 1.0000000 | 0.918 | NA | NA |
| ERBB3 | docetaxel | 0.9341703 | 1.0000000 | 0.934 | NA | NA |
| WT1 | docetaxel | 0.9351699 | 1.0000000 | 0.935 | NA | NA |
| BRCA2 | docetaxel | 0.9459713 | 1.0000000 | 0.946 | NA | NA |
| SMC3 | docetaxel | 0.9535364 | 1.0000000 | 0.954 | NA | NA |
| NRAS | docetaxel | 0.9692192 | 1.0000000 | 0.969 | NA | NA |
| KRAS | docetaxel | 0.9823871 | 1.0000000 | 0.982 | NA | NA |
| GNB1 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| STAT3 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NPM1 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MET | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MAP2K1 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA2 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MYD88 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SSX1 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PDGFB | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PRPF40B | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SH2B3 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PIGA | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CXCR4 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT1 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CTLA4 | docetaxel | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMO | vismodegib | 0.5979370 | 1.0000000 | 0.598 | NA | NA |
| ERBB2 | vismodegib | 0.6212956 | 1.0000000 | 0.621 | NA | NA |
| PML | vismodegib | 0.6327203 | 1.0000000 | 0.633 | NA | NA |
| GNB1 | vismodegib | 0.6605492 | 1.0000000 | 0.661 | NA | NA |
| CDK4 | vismodegib | 0.6959426 | 1.0000000 | 0.696 | NA | NA |
| GNAS | vismodegib | 0.7040976 | 1.0000000 | 0.704 | NA | NA |
| PTCH1 | vismodegib | 0.7059781 | 1.0000000 | 0.706 | NA | NA |
| PDGFRA | vismodegib | 0.7093196 | 1.0000000 | 0.709 | NA | NA |
| STAT3 | vismodegib | 0.7115314 | 1.0000000 | 0.712 | NA | NA |
| SH2B3 | vismodegib | 0.7133032 | 1.0000000 | 0.713 | NA | NA |
| ROS1 | vismodegib | 0.7262074 | 1.0000000 | 0.726 | NA | NA |
| KMT2A | vismodegib | 0.7304515 | 1.0000000 | 0.730 | NA | NA |
| PAX8 | vismodegib | 0.7655945 | 1.0000000 | 0.766 | NA | NA |
| PTEN | vismodegib | 0.7677188 | 1.0000000 | 0.768 | NA | NA |
| SMC3 | vismodegib | 0.7707975 | 1.0000000 | 0.771 | NA | NA |
| CRLF2 | vismodegib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| KIT | vismodegib | 0.7770588 | 1.0000000 | 0.777 | NA | NA |
| EGF | vismodegib | 0.7771237 | 1.0000000 | 0.777 | NA | NA |
| ALK | vismodegib | 0.7904980 | 1.0000000 | 0.790 | NA | NA |
| CTNNB1 | vismodegib | 0.7929163 | 1.0000000 | 0.793 | NA | NA |
| CXCR4 | vismodegib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| WT1 | vismodegib | 0.8072104 | 1.0000000 | 0.807 | NA | NA |
| PDGFRB | vismodegib | 0.8120916 | 1.0000000 | 0.812 | NA | NA |
| ASXL1 | vismodegib | 0.8148713 | 1.0000000 | 0.815 | NA | NA |
| EGFR | vismodegib | 0.8325789 | 1.0000000 | 0.833 | NA | NA |
| AR | vismodegib | 0.8384101 | 1.0000000 | 0.838 | NA | NA |
| PAX5 | vismodegib | 0.8464506 | 1.0000000 | 0.846 | NA | NA |
| NRAS | vismodegib | 0.8470075 | 1.0000000 | 0.847 | NA | NA |
| NOTCH2 | vismodegib | 0.8541769 | 1.0000000 | 0.854 | NA | NA |
| SMC1A | vismodegib | 0.8596838 | 1.0000000 | 0.860 | NA | NA |
| FGFR3 | vismodegib | 0.8813501 | 1.0000000 | 0.881 | NA | NA |
| IKZF1 | vismodegib | 0.8874141 | 1.0000000 | 0.887 | NA | NA |
| PRPF8 | vismodegib | 0.8929799 | 1.0000000 | 0.893 | NA | NA |
| SETD2 | vismodegib | 0.9097982 | 1.0000000 | 0.910 | NA | NA |
| BCORL1 | vismodegib | 0.9157680 | 1.0000000 | 0.916 | NA | NA |
| FGFR2 | vismodegib | 0.9272645 | 1.0000000 | 0.927 | NA | NA |
| MET | vismodegib | 0.9746506 | 1.0000000 | 0.975 | NA | NA |
| IDH2 | vismodegib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MYCN | vismodegib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MGMT | vismodegib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CALR | vismodegib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA1 | vismodegib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SF1 | vismodegib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CD79B | vismodegib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PIGA | vismodegib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT1 | vismodegib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PDGFRB | tretinoin | 0.1179267 | 1.0000000 | 0.1179 | NA | NA |
| TP53 | tretinoin | 0.1306260 | 1.0000000 | 0.1306 | NA | NA |
| G6PD | tretinoin | 0.1489147 | 1.0000000 | 0.1489 | NA | NA |
| BTK | tretinoin | 0.1563757 | 1.0000000 | 0.1564 | NA | NA |
| IDH1 | tretinoin | 0.1904303 | 1.0000000 | 0.1904 | NA | NA |
| BRCA1 | tretinoin | 0.2205710 | 1.0000000 | 0.2206 | NA | NA |
| GATA1 | tretinoin | 0.2410324 | 1.0000000 | 0.2410 | NA | NA |
| JAK2 | tretinoin | 0.2433046 | 1.0000000 | 0.2433 | NA | NA |
| AKT3 | tretinoin | 0.2471600 | 1.0000000 | 0.2472 | NA | NA |
| NT5C2 | tretinoin | 0.2471600 | 1.0000000 | 0.2472 | NA | NA |
| DPYD | tretinoin | 0.2529054 | 1.0000000 | 0.2529 | NA | NA |
| SETD2 | tretinoin | 0.2572433 | 1.0000000 | 0.2572 | NA | NA |
| IKZF1 | tretinoin | 0.2573755 | 1.0000000 | 0.2574 | NA | NA |
| PTEN | tretinoin | 0.2758896 | 1.0000000 | 0.2759 | NA | NA |
| HRAS | tretinoin | 0.2888444 | 1.0000000 | 0.2888 | NA | NA |
| AKT2 | tretinoin | 0.2888444 | 1.0000000 | 0.2888 | NA | NA |
| SMC3 | tretinoin | 0.2942726 | 1.0000000 | 0.2943 | NA | NA |
| FGFR1 | tretinoin | 0.3064822 | 1.0000000 | 0.3065 | NA | NA |
| DNMT3A | tretinoin | 0.3068773 | 1.0000000 | 0.3069 | NA | NA |
| FBXW7 | tretinoin | 0.3145586 | 1.0000000 | 0.3146 | NA | NA |
| CTCF | tretinoin | 0.3322673 | 1.0000000 | 0.3323 | NA | NA |
| PAX5 | tretinoin | 0.3329216 | 1.0000000 | 0.3329 | NA | NA |
| NOTCH1 | tretinoin | 0.3349399 | 1.0000000 | 0.3349 | NA | NA |
| TSC2 | tretinoin | 0.3543585 | 1.0000000 | 0.3544 | NA | NA |
| STAT3 | tretinoin | 0.3552259 | 1.0000000 | 0.3552 | NA | NA |
| WHSC1 | tretinoin | 0.3647740 | 1.0000000 | 0.3648 | NA | NA |
| SSX1 | tretinoin | 0.3710934 | 1.0000000 | 0.3711 | NA | NA |
| DDIT3 | tretinoin | 0.3864762 | 1.0000000 | 0.3865 | NA | NA |
| GATA3 | tretinoin | 0.3952428 | 1.0000000 | 0.3952 | NA | NA |
| ROS1 | tretinoin | 0.4424632 | 1.0000000 | 0.4425 | NA | NA |
| PML | tretinoin | 0.4526598 | 1.0000000 | 0.4527 | NA | NA |
| CBL | tretinoin | 0.4532547 | 1.0000000 | 0.4533 | NA | NA |
| FGFR3 | tretinoin | 0.4577319 | 1.0000000 | 0.4577 | NA | NA |
| WT1 | tretinoin | 0.4641203 | 1.0000000 | 0.4641 | NA | NA |
| ATM | tretinoin | 0.4763120 | 1.0000000 | 0.4763 | NA | NA |
| FGFR2 | tretinoin | 0.4896603 | 1.0000000 | 0.4897 | NA | NA |
| AR | tretinoin | 0.4966574 | 1.0000000 | 0.4967 | NA | NA |
| ERBB3 | tretinoin | 0.5125322 | 1.0000000 | 0.5125 | NA | NA |
| BCOR | tretinoin | 0.5167279 | 1.0000000 | 0.5167 | NA | NA |
| SMO | tretinoin | 0.5268359 | 1.0000000 | 0.5268 | NA | NA |
| EGF | tretinoin | 0.5334473 | 1.0000000 | 0.5334 | NA | NA |
| CTLA4 | tretinoin | 0.5402914 | 1.0000000 | 0.5403 | NA | NA |
| PTCH1 | tretinoin | 0.5415255 | 1.0000000 | 0.5415 | NA | NA |
| BRCA2 | tretinoin | 0.5419273 | 1.0000000 | 0.5419 | NA | NA |
| CREBBP | tretinoin | 0.5427437 | 1.0000000 | 0.5427 | NA | NA |
| BCORL1 | tretinoin | 0.5489458 | 1.0000000 | 0.5489 | NA | NA |
| UGT1A1 | tretinoin | 0.5565355 | 1.0000000 | 0.5565 | NA | NA |
| PDGFB | tretinoin | 0.5581846 | 1.0000000 | 0.5582 | NA | NA |
| MAP2K1 | tretinoin | 0.5612758 | 1.0000000 | 0.5613 | NA | NA |
| JAK3 | tretinoin | 0.5630049 | 1.0000000 | 0.5630 | NA | NA |
| PRPF40B | tretinoin | 0.5703340 | 1.0000000 | 0.5703 | NA | NA |
| IL7R | tretinoin | 0.5707504 | 1.0000000 | 0.5708 | NA | NA |
| PDGFRA | tretinoin | 0.6017552 | 1.0000000 | 0.6018 | NA | NA |
| ABL1 | tretinoin | 0.6064676 | 1.0000000 | 0.6065 | NA | NA |
| CTNNB1 | tretinoin | 0.6199780 | 1.0000000 | 0.6200 | NA | NA |
| PIGA | tretinoin | 0.6373519 | 1.0000000 | 0.6374 | NA | NA |
| NRAS | tretinoin | 0.6454372 | 1.0000000 | 0.6454 | NA | NA |
| BRAF | tretinoin | 0.6596748 | 1.0000000 | 0.6597 | NA | NA |
| PIK3CA | tretinoin | 0.6649072 | 1.0000000 | 0.6649 | NA | NA |
| RET | tretinoin | 0.6865042 | 1.0000000 | 0.6865 | NA | NA |
| CRLF2 | tretinoin | 0.6985354 | 1.0000000 | 0.6985 | NA | NA |
| MYCN | tretinoin | 0.7133032 | 1.0000000 | 0.7133 | NA | NA |
| SH2B3 | tretinoin | 0.7133032 | 1.0000000 | 0.7133 | NA | NA |
| AKT1 | tretinoin | 0.7212767 | 1.0000000 | 0.7213 | NA | NA |
| CALR | tretinoin | 0.7236736 | 1.0000000 | 0.7237 | NA | NA |
| CD79B | tretinoin | 0.7236736 | 1.0000000 | 0.7237 | NA | NA |
| MET | tretinoin | 0.7266861 | 1.0000000 | 0.7267 | NA | NA |
| GNAS | tretinoin | 0.7339947 | 1.0000000 | 0.7340 | NA | NA |
| EGFR | tretinoin | 0.7351882 | 1.0000000 | 0.7352 | NA | NA |
| NPM1 | tretinoin | 0.7728300 | 1.0000000 | 0.7728 | NA | NA |
| SRSF2 | tretinoin | 0.7728300 | 1.0000000 | 0.7728 | NA | NA |
| ERBB4 | tretinoin | 0.7871837 | 1.0000000 | 0.7872 | NA | NA |
| ERBB2 | tretinoin | 0.7902330 | 1.0000000 | 0.7902 | NA | NA |
| CBLB | tretinoin | 0.7998461 | 1.0000000 | 0.7998 | NA | NA |
| CXCR4 | tretinoin | 0.8025873 | 1.0000000 | 0.8026 | NA | NA |
| SETBP1 | tretinoin | 0.8101625 | 1.0000000 | 0.8102 | NA | NA |
| ASXL1 | tretinoin | 0.8148713 | 1.0000000 | 0.8149 | NA | NA |
| STAG2 | tretinoin | 0.8230633 | 1.0000000 | 0.8231 | NA | NA |
| EZH2 | tretinoin | 0.8282625 | 1.0000000 | 0.8283 | NA | NA |
| RAD21 | tretinoin | 0.8433133 | 1.0000000 | 0.8433 | NA | NA |
| GNA11 | tretinoin | 0.8464506 | 1.0000000 | 0.8465 | NA | NA |
| SMC1A | tretinoin | 0.8596838 | 1.0000000 | 0.8597 | NA | NA |
| VHL | tretinoin | 0.8807910 | 1.0000000 | 0.8808 | NA | NA |
| CDKN2A | tretinoin | 0.8860723 | 1.0000000 | 0.8861 | NA | NA |
| TET2 | tretinoin | 0.9522319 | 1.0000000 | 0.9522 | NA | NA |
| IDH2 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| MGMT | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| GNB1 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| TSC1 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| PRPF8 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| SF3B1 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| ETV6 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| KMT2A | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| KIT | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| MYD88 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| SF1 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| NCOA2 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| PAX8 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| ESR1 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| MPL | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| CDK4 | tretinoin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| SMO | bosutinib monohydrate | 0.9159998 | 1.0000000 | 0.916 | NA | NA |
| PDGFRA | bosutinib monohydrate | 0.9405696 | 1.0000000 | 0.941 | NA | NA |
| EGF | bosutinib monohydrate | 0.9548528 | 1.0000000 | 0.955 | NA | NA |
| ROS1 | bosutinib monohydrate | 0.9650862 | 1.0000000 | 0.965 | NA | NA |
| NPM1 | bosutinib monohydrate | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NT5C2 | bosutinib monohydrate | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SF3B1 | bosutinib monohydrate | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| WT1 | bosutinib monohydrate | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PAX8 | bosutinib monohydrate | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CD79B | bosutinib monohydrate | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT2 | bosutinib monohydrate | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PIK3CA | nilotinib | 0.3254032 | 1.0000000 | 0.325 | NA | NA |
| ETV6 | nilotinib | 0.3373557 | 1.0000000 | 0.337 | NA | NA |
| SMC1A | nilotinib | 0.3767591 | 1.0000000 | 0.377 | NA | NA |
| BCORL1 | nilotinib | 0.3781105 | 1.0000000 | 0.378 | NA | NA |
| MPL | nilotinib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| G6PD | nilotinib | 0.3864762 | 1.0000000 | 0.386 | NA | NA |
| ZRSR2 | nilotinib | 0.3864762 | 1.0000000 | 0.386 | NA | NA |
| XPO1 | nilotinib | 0.4046568 | 1.0000000 | 0.405 | NA | NA |
| RET | nilotinib | 0.4362749 | 1.0000000 | 0.436 | NA | NA |
| BCOR | nilotinib | 0.4470053 | 1.0000000 | 0.447 | NA | NA |
| SMO | nilotinib | 0.4603216 | 1.0000000 | 0.460 | NA | NA |
| NRAS | nilotinib | 0.4634580 | 1.0000000 | 0.463 | NA | NA |
| AKT3 | nilotinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| GNA11 | nilotinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| SETD2 | nilotinib | 0.4926027 | 1.0000000 | 0.493 | NA | NA |
| KIT | nilotinib | 0.4983717 | 1.0000000 | 0.498 | NA | NA |
| ALK | nilotinib | 0.5324420 | 1.0000000 | 0.532 | NA | NA |
| DDIT3 | nilotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| CTLA4 | nilotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| ATM | nilotinib | 0.5426643 | 1.0000000 | 0.543 | NA | NA |
| TET2 | nilotinib | 0.5499800 | 1.0000000 | 0.550 | NA | NA |
| CSF3R | nilotinib | 0.5541131 | 1.0000000 | 0.554 | NA | NA |
| UGT1A1 | nilotinib | 0.5565355 | 1.0000000 | 0.557 | NA | NA |
| PDGFB | nilotinib | 0.5581846 | 1.0000000 | 0.558 | NA | NA |
| PAX5 | nilotinib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| MAP2K1 | nilotinib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| WHSC1 | nilotinib | 0.5620826 | 1.0000000 | 0.562 | NA | NA |
| PDGFRB | nilotinib | 0.5686182 | 1.0000000 | 0.569 | NA | NA |
| FGFR3 | nilotinib | 0.6063626 | 1.0000000 | 0.606 | NA | NA |
| SF3B1 | nilotinib | 0.6101655 | 1.0000000 | 0.610 | NA | NA |
| EGFR | nilotinib | 0.6282405 | 1.0000000 | 0.628 | NA | NA |
| PTEN | nilotinib | 0.6336810 | 1.0000000 | 0.634 | NA | NA |
| PIGA | nilotinib | 0.6373519 | 1.0000000 | 0.637 | NA | NA |
| CTNNB1 | nilotinib | 0.6586643 | 1.0000000 | 0.659 | NA | NA |
| GNB1 | nilotinib | 0.6605492 | 1.0000000 | 0.661 | NA | NA |
| SH2B3 | nilotinib | 0.6650055 | 1.0000000 | 0.665 | NA | NA |
| ERBB3 | nilotinib | 0.6796099 | 1.0000000 | 0.680 | NA | NA |
| ROS1 | nilotinib | 0.6992900 | 1.0000000 | 0.699 | NA | NA |
| BRCA1 | nilotinib | 0.7090407 | 1.0000000 | 0.709 | NA | NA |
| PML | nilotinib | 0.7212961 | 1.0000000 | 0.721 | NA | NA |
| NT5C2 | nilotinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| MYD88 | nilotinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| CXCR4 | nilotinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| EZH2 | nilotinib | 0.7284542 | 1.0000000 | 0.728 | NA | NA |
| NCOA2 | nilotinib | 0.7287085 | 1.0000000 | 0.729 | NA | NA |
| FBXW7 | nilotinib | 0.7369822 | 1.0000000 | 0.737 | NA | NA |
| FGFR2 | nilotinib | 0.7472620 | 1.0000000 | 0.747 | NA | NA |
| NPM1 | nilotinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| CD79B | nilotinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| ERBB2 | nilotinib | 0.7902330 | 1.0000000 | 0.790 | NA | NA |
| CBLB | nilotinib | 0.7998461 | 1.0000000 | 0.800 | NA | NA |
| CALR | nilotinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| VHL | nilotinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| STAT3 | nilotinib | 0.8197075 | 1.0000000 | 0.820 | NA | NA |
| GATA3 | nilotinib | 0.8444630 | 1.0000000 | 0.844 | NA | NA |
| ESR1 | nilotinib | 0.8533074 | 1.0000000 | 0.853 | NA | NA |
| EGF | nilotinib | 0.8651347 | 1.0000000 | 0.865 | NA | NA |
| GATA2 | nilotinib | 0.8709912 | 1.0000000 | 0.871 | NA | NA |
| DPYD | nilotinib | 0.9069783 | 1.0000000 | 0.907 | NA | NA |
| TSC1 | nilotinib | 0.9144580 | 1.0000000 | 0.914 | NA | NA |
| WT1 | nilotinib | 0.9351699 | 1.0000000 | 0.935 | NA | NA |
| MET | nilotinib | 0.9378870 | 1.0000000 | 0.938 | NA | NA |
| CDKN2A | nilotinib | 0.9724174 | 1.0000000 | 0.972 | NA | NA |
| IDH2 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MYCN | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| IKZF1 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AR | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| KRAS | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SETBP1 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| JAK3 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA1 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SF1 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PAX8 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PRPF40B | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ASXL1 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CDK4 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT2 | nilotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SETBP1 | trametinib | 0.0631425 | 1.0000000 | 0.063 | NA | NA |
| PIK3CA | trametinib | 0.1161003 | 1.0000000 | 0.116 | NA | NA |
| FGFR2 | trametinib | 0.1206908 | 1.0000000 | 0.121 | NA | NA |
| NCOA2 | trametinib | 0.1358334 | 1.0000000 | 0.136 | NA | NA |
| CBLB | trametinib | 0.1390867 | 1.0000000 | 0.139 | NA | NA |
| SMO | trametinib | 0.1397736 | 1.0000000 | 0.140 | NA | NA |
| ERBB2 | trametinib | 0.1602162 | 1.0000000 | 0.160 | NA | NA |
| GNB1 | trametinib | 0.1714602 | 1.0000000 | 0.171 | NA | NA |
| CBL | trametinib | 0.1904303 | 1.0000000 | 0.190 | NA | NA |
| STAG2 | trametinib | 0.1930591 | 1.0000000 | 0.193 | NA | NA |
| CTCF | trametinib | 0.2048400 | 1.0000000 | 0.205 | NA | NA |
| FGFR1 | trametinib | 0.2157783 | 1.0000000 | 0.216 | NA | NA |
| MGMT | trametinib | 0.2330380 | 1.0000000 | 0.233 | NA | NA |
| PDGFB | trametinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| AKT3 | trametinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| CTLA4 | trametinib | 0.2452781 | 1.0000000 | 0.245 | NA | NA |
| BRCA1 | trametinib | 0.2664388 | 1.0000000 | 0.266 | NA | NA |
| NOTCH1 | trametinib | 0.2691595 | 1.0000000 | 0.269 | NA | NA |
| GATA1 | trametinib | 0.2723606 | 1.0000000 | 0.272 | NA | NA |
| KMT2A | trametinib | 0.2831345 | 1.0000000 | 0.283 | NA | NA |
| AR | trametinib | 0.3103990 | 1.0000000 | 0.310 | NA | NA |
| EML4 | trametinib | 0.3140923 | 1.0000000 | 0.314 | NA | NA |
| ATM | trametinib | 0.3337484 | 1.0000000 | 0.334 | NA | NA |
| RAD21 | trametinib | 0.3416822 | 1.0000000 | 0.342 | NA | NA |
| TET2 | trametinib | 0.3442850 | 1.0000000 | 0.344 | NA | NA |
| BTK | trametinib | 0.3502376 | 1.0000000 | 0.350 | NA | NA |
| ZRSR2 | trametinib | 0.3593968 | 1.0000000 | 0.359 | NA | NA |
| SF1 | trametinib | 0.3619348 | 1.0000000 | 0.362 | NA | NA |
| CDK6 | trametinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| MET | trametinib | 0.3737145 | 1.0000000 | 0.374 | NA | NA |
| DPYD | trametinib | 0.3737145 | 1.0000000 | 0.374 | NA | NA |
| SMC3 | trametinib | 0.3821206 | 1.0000000 | 0.382 | NA | NA |
| IDH1 | trametinib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| IKZF1 | trametinib | 0.3912838 | 1.0000000 | 0.391 | NA | NA |
| BCOR | trametinib | 0.4038311 | 1.0000000 | 0.404 | NA | NA |
| PML | trametinib | 0.4072673 | 1.0000000 | 0.407 | NA | NA |
| EGF | trametinib | 0.4291953 | 1.0000000 | 0.429 | NA | NA |
| BRAF | trametinib | 0.4374152 | 1.0000000 | 0.437 | NA | NA |
| XPO1 | trametinib | 0.4446962 | 1.0000000 | 0.445 | NA | NA |
| DNAJB1 | trametinib | 0.4532547 | 1.0000000 | 0.453 | NA | NA |
| ALK | trametinib | 0.4662913 | 1.0000000 | 0.466 | NA | NA |
| NPM1 | trametinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| NT5C2 | trametinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| G6PD | trametinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| HRAS | trametinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| CDK4 | trametinib | 0.5024303 | 1.0000000 | 0.502 | NA | NA |
| GNAS | trametinib | 0.5272297 | 1.0000000 | 0.527 | NA | NA |
| MYCN | trametinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| TSC2 | trametinib | 0.5461873 | 1.0000000 | 0.546 | NA | NA |
| ASXL1 | trametinib | 0.5489458 | 1.0000000 | 0.549 | NA | NA |
| MYD88 | trametinib | 0.5581846 | 1.0000000 | 0.558 | NA | NA |
| RUNX1 | trametinib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| MAP2K1 | trametinib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| VHL | trametinib | 0.5676354 | 1.0000000 | 0.568 | NA | NA |
| DNMT3A | trametinib | 0.5700925 | 1.0000000 | 0.570 | NA | NA |
| FLT3 | trametinib | 0.6017552 | 1.0000000 | 0.602 | NA | NA |
| ROS1 | trametinib | 0.6065156 | 1.0000000 | 0.607 | NA | NA |
| ERBB4 | trametinib | 0.6170396 | 1.0000000 | 0.617 | NA | NA |
| MPL | trametinib | 0.6352563 | 1.0000000 | 0.635 | NA | NA |
| WHSC1 | trametinib | 0.6394022 | 1.0000000 | 0.639 | NA | NA |
| UGT1A1 | trametinib | 0.6464996 | 1.0000000 | 0.646 | NA | NA |
| IL7R | trametinib | 0.6592430 | 1.0000000 | 0.659 | NA | NA |
| SMC1A | trametinib | 0.6650055 | 1.0000000 | 0.665 | NA | NA |
| TSC1 | trametinib | 0.6708487 | 1.0000000 | 0.671 | NA | NA |
| ABL1 | trametinib | 0.6723358 | 1.0000000 | 0.672 | NA | NA |
| EZH2 | trametinib | 0.7093881 | 1.0000000 | 0.709 | NA | NA |
| PDGFRB | trametinib | 0.7121354 | 1.0000000 | 0.712 | NA | NA |
| RET | trametinib | 0.7121781 | 1.0000000 | 0.712 | NA | NA |
| KIT | trametinib | 0.7130582 | 1.0000000 | 0.713 | NA | NA |
| FBXW7 | trametinib | 0.7145130 | 1.0000000 | 0.715 | NA | NA |
| JAK3 | trametinib | 0.7336372 | 1.0000000 | 0.734 | NA | NA |
| PTCH1 | trametinib | 0.7342064 | 1.0000000 | 0.734 | NA | NA |
| PAX8 | trametinib | 0.7491191 | 1.0000000 | 0.749 | NA | NA |
| SRSF2 | trametinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| ETV6 | trametinib | 0.7989067 | 1.0000000 | 0.799 | NA | NA |
| STAT3 | trametinib | 0.7998461 | 1.0000000 | 0.800 | NA | NA |
| ESR1 | trametinib | 0.7998461 | 1.0000000 | 0.800 | NA | NA |
| JAK1 | trametinib | 0.8012974 | 1.0000000 | 0.801 | NA | NA |
| NRAS | trametinib | 0.8020445 | 1.0000000 | 0.802 | NA | NA |
| FGFR3 | trametinib | 0.8050729 | 1.0000000 | 0.805 | NA | NA |
| NOTCH2 | trametinib | 0.8156757 | 1.0000000 | 0.816 | NA | NA |
| CALR | trametinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| PAX5 | trametinib | 0.8197075 | 1.0000000 | 0.820 | NA | NA |
| TP53 | trametinib | 0.8228175 | 1.0000000 | 0.823 | NA | NA |
| CREBBP | trametinib | 0.8358316 | 1.0000000 | 0.836 | NA | NA |
| PRPF8 | trametinib | 0.8414119 | 1.0000000 | 0.841 | NA | NA |
| AKT2 | trametinib | 0.8464506 | 1.0000000 | 0.846 | NA | NA |
| EGFR | trametinib | 0.8542914 | 1.0000000 | 0.854 | NA | NA |
| BRCA2 | trametinib | 0.8856044 | 1.0000000 | 0.886 | NA | NA |
| BCORL1 | trametinib | 0.8886105 | 1.0000000 | 0.889 | NA | NA |
| CDKN2A | trametinib | 0.8936624 | 1.0000000 | 0.894 | NA | NA |
| PRPF40B | trametinib | 0.9032663 | 1.0000000 | 0.903 | NA | NA |
| ERBB3 | trametinib | 0.9341703 | 1.0000000 | 0.934 | NA | NA |
| SH2B3 | trametinib | 0.9361863 | 1.0000000 | 0.936 | NA | NA |
| CSF3R | trametinib | 0.9511703 | 1.0000000 | 0.951 | NA | NA |
| KRAS | trametinib | 0.9820637 | 1.0000000 | 0.982 | NA | NA |
| IDH2 | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PDGFRA | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CRLF2 | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SETD2 | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GNA11 | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CD79B | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PIGA | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CXCR4 | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| DDIT3 | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| JAK2 | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT1 | trametinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PDGFRB | midostaurin | 0.0097966 | 1.0000000 | 0.0098 | ** | NA |
| ETV6 | midostaurin | 0.0283773 | 1.0000000 | 0.0284 |
|
NA |
| ERBB3 | midostaurin | 0.0742813 | 1.0000000 | 0.0743 | NA | NA |
| TSC2 | midostaurin | 0.0822765 | 1.0000000 | 0.0823 | NA | NA |
| EGF | midostaurin | 0.1152906 | 1.0000000 | 0.1153 | NA | NA |
| KIT | midostaurin | 0.1168579 | 1.0000000 | 0.1169 | NA | NA |
| STAG2 | midostaurin | 0.1206908 | 1.0000000 | 0.1207 | NA | NA |
| PTCH1 | midostaurin | 0.1298475 | 1.0000000 | 0.1298 | NA | NA |
| IL7R | midostaurin | 0.1312104 | 1.0000000 | 0.1312 | NA | NA |
| SETD2 | midostaurin | 0.1382390 | 1.0000000 | 0.1382 | NA | NA |
| DDIT3 | midostaurin | 0.1489147 | 1.0000000 | 0.1489 | NA | NA |
| FGFR3 | midostaurin | 0.1512811 | 1.0000000 | 0.1513 | NA | NA |
| VHL | midostaurin | 0.1521073 | 1.0000000 | 0.1521 | NA | NA |
| AKT3 | midostaurin | 0.1752442 | 1.0000000 | 0.1752 | NA | NA |
| IDH1 | midostaurin | 0.1876828 | 1.0000000 | 0.1877 | NA | NA |
| CXCR4 | midostaurin | 0.2112995 | 1.0000000 | 0.2113 | NA | NA |
| GNAS | midostaurin | 0.2193678 | 1.0000000 | 0.2194 | NA | NA |
| JAK2 | midostaurin | 0.2216120 | 1.0000000 | 0.2216 | NA | NA |
| ERBB2 | midostaurin | 0.2222590 | 1.0000000 | 0.2223 | NA | NA |
| PML | midostaurin | 0.2328442 | 1.0000000 | 0.2328 | NA | NA |
| CALR | midostaurin | 0.2471600 | 1.0000000 | 0.2472 | NA | NA |
| JAK1 | midostaurin | 0.2532459 | 1.0000000 | 0.2532 | NA | NA |
| MYD88 | midostaurin | 0.2888444 | 1.0000000 | 0.2888 | NA | NA |
| MAP2K1 | midostaurin | 0.2962699 | 1.0000000 | 0.2963 | NA | NA |
| ROS1 | midostaurin | 0.3064280 | 1.0000000 | 0.3064 | NA | NA |
| SH2B3 | midostaurin | 0.3153025 | 1.0000000 | 0.3153 | NA | NA |
| CSF3R | midostaurin | 0.3502376 | 1.0000000 | 0.3502 | NA | NA |
| STAT3 | midostaurin | 0.3525421 | 1.0000000 | 0.3525 | NA | NA |
| PRPF8 | midostaurin | 0.3679101 | 1.0000000 | 0.3679 | NA | NA |
| ATM | midostaurin | 0.3684968 | 1.0000000 | 0.3685 | NA | NA |
| NRAS | midostaurin | 0.3687105 | 1.0000000 | 0.3687 | NA | NA |
| IDH2 | midostaurin | 0.3710934 | 1.0000000 | 0.3711 | NA | NA |
| NCOA2 | midostaurin | 0.3746505 | 1.0000000 | 0.3747 | NA | NA |
| GATA1 | midostaurin | 0.3777807 | 1.0000000 | 0.3778 | NA | NA |
| NT5C2 | midostaurin | 0.3864762 | 1.0000000 | 0.3865 | NA | NA |
| GNA11 | midostaurin | 0.3864762 | 1.0000000 | 0.3865 | NA | NA |
| SRSF2 | midostaurin | 0.3864762 | 1.0000000 | 0.3865 | NA | NA |
| WT1 | midostaurin | 0.3907143 | 1.0000000 | 0.3907 | NA | NA |
| FGFR2 | midostaurin | 0.4128303 | 1.0000000 | 0.4128 | NA | NA |
| FLT3 | midostaurin | 0.4171891 | 1.0000000 | 0.4172 | NA | NA |
| DNMT3A | midostaurin | 0.4171891 | 1.0000000 | 0.4172 | NA | NA |
| ALK | midostaurin | 0.4270694 | 1.0000000 | 0.4271 | NA | NA |
| RUNX1 | midostaurin | 0.4291953 | 1.0000000 | 0.4292 | NA | NA |
| NOTCH1 | midostaurin | 0.4329265 | 1.0000000 | 0.4329 | NA | NA |
| AKT1 | midostaurin | 0.4605582 | 1.0000000 | 0.4606 | NA | NA |
| EZH2 | midostaurin | 0.4650038 | 1.0000000 | 0.4650 | NA | NA |
| TET2 | midostaurin | 0.4704864 | 1.0000000 | 0.4705 | NA | NA |
| BRCA2 | midostaurin | 0.4765591 | 1.0000000 | 0.4766 | NA | NA |
| BCOR | midostaurin | 0.4847907 | 1.0000000 | 0.4848 | NA | NA |
| G6PD | midostaurin | 0.4874533 | 1.0000000 | 0.4875 | NA | NA |
| PAX5 | midostaurin | 0.4941245 | 1.0000000 | 0.4941 | NA | NA |
| FGFR1 | midostaurin | 0.5160638 | 1.0000000 | 0.5161 | NA | NA |
| RAD21 | midostaurin | 0.5185170 | 1.0000000 | 0.5185 | NA | NA |
| SF1 | midostaurin | 0.5186050 | 1.0000000 | 0.5186 | NA | NA |
| CTLA4 | midostaurin | 0.5402914 | 1.0000000 | 0.5403 | NA | NA |
| ERBB4 | midostaurin | 0.5623068 | 1.0000000 | 0.5623 | NA | NA |
| FBXW7 | midostaurin | 0.5701297 | 1.0000000 | 0.5701 | NA | NA |
| CBLB | midostaurin | 0.5790997 | 1.0000000 | 0.5791 | NA | NA |
| ABL1 | midostaurin | 0.5995102 | 1.0000000 | 0.5995 | NA | NA |
| MET | midostaurin | 0.6238073 | 1.0000000 | 0.6238 | NA | NA |
| TP53 | midostaurin | 0.6469162 | 1.0000000 | 0.6469 | NA | NA |
| CD79B | midostaurin | 0.6625206 | 1.0000000 | 0.6625 | NA | NA |
| SMC1A | midostaurin | 0.6650055 | 1.0000000 | 0.6650 | NA | NA |
| CTCF | midostaurin | 0.6708487 | 1.0000000 | 0.6708 | NA | NA |
| CTNNB1 | midostaurin | 0.6961716 | 1.0000000 | 0.6962 | NA | NA |
| PDGFRA | midostaurin | 0.7070567 | 1.0000000 | 0.7071 | NA | NA |
| ASXL1 | midostaurin | 0.7268003 | 1.0000000 | 0.7268 | NA | NA |
| SMC3 | midostaurin | 0.7340460 | 1.0000000 | 0.7340 | NA | NA |
| CDK4 | midostaurin | 0.7373721 | 1.0000000 | 0.7374 | NA | NA |
| PAX8 | midostaurin | 0.7491191 | 1.0000000 | 0.7491 | NA | NA |
| KMT2A | midostaurin | 0.7501271 | 1.0000000 | 0.7501 | NA | NA |
| XPO1 | midostaurin | 0.7768140 | 1.0000000 | 0.7768 | NA | NA |
| CREBBP | midostaurin | 0.7908790 | 1.0000000 | 0.7909 | NA | NA |
| DNAJB1 | midostaurin | 0.8025873 | 1.0000000 | 0.8026 | NA | NA |
| EGFR | midostaurin | 0.8071948 | 1.0000000 | 0.8072 | NA | NA |
| GATA2 | midostaurin | 0.8262002 | 1.0000000 | 0.8262 | NA | NA |
| SMO | midostaurin | 0.8435541 | 1.0000000 | 0.8436 | NA | NA |
| BRAF | midostaurin | 0.8461246 | 1.0000000 | 0.8461 | NA | NA |
| MGMT | midostaurin | 0.8464506 | 1.0000000 | 0.8465 | NA | NA |
| PRPF40B | midostaurin | 0.8759990 | 1.0000000 | 0.8760 | NA | NA |
| NOTCH2 | midostaurin | 0.9024811 | 1.0000000 | 0.9025 | NA | NA |
| DPYD | midostaurin | 0.9031158 | 1.0000000 | 0.9031 | NA | NA |
| PTEN | midostaurin | 0.9059535 | 1.0000000 | 0.9060 | NA | NA |
| WHSC1 | midostaurin | 0.9159998 | 1.0000000 | 0.9160 | NA | NA |
| UGT1A1 | midostaurin | 0.9243755 | 1.0000000 | 0.9244 | NA | NA |
| TSC1 | midostaurin | 0.9322640 | 1.0000000 | 0.9323 | NA | NA |
| BTK | midostaurin | 0.9323244 | 1.0000000 | 0.9323 | NA | NA |
| SETBP1 | midostaurin | 0.9412443 | 1.0000000 | 0.9412 | NA | NA |
| CDKN2A | midostaurin | 0.9414999 | 1.0000000 | 0.9415 | NA | NA |
| RET | midostaurin | 0.9579673 | 1.0000000 | 0.9580 | NA | NA |
| SF3B1 | midostaurin | 0.9702439 | 1.0000000 | 0.9702 | NA | NA |
| AR | midostaurin | 0.9716299 | 1.0000000 | 0.9716 | NA | NA |
| KRAS | midostaurin | 0.9826990 | 1.0000000 | 0.9827 | NA | NA |
| MYCN | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| IKZF1 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| GNB1 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| NPM1 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| BCORL1 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| GATA3 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| JAK3 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| BRCA1 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| EML4 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| CRLF2 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| SSX1 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| ESR1 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| PDGFB | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| AKT2 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| CBL | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| ZRSR2 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| HRAS | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| CDK6 | midostaurin | 1.0000000 | 1.0000000 | 1.0000 | NA | NA |
| XPO1 | pazopanib | 0.9247190 | 1.0000000 | 0.925 | NA | NA |
| FBXW7 | pazopanib | 0.9271927 | 1.0000000 | 0.927 | NA | NA |
| PTEN | pazopanib | 0.9517309 | 1.0000000 | 0.952 | NA | NA |
| IDH2 | pazopanib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB2 | pazopanib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| STAT3 | pazopanib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB4 | pazopanib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| RAD21 | pazopanib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| EGFR | pazopanib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ESR1 | pazopanib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GNA11 | pazopanib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| HRAS | pazopanib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| RET | ponatinib | 0.4291953 | 1.0000000 | 0.429 | NA | NA |
| ETV6 | ponatinib | 0.4366766 | 1.0000000 | 0.437 | NA | NA |
| STAT3 | ponatinib | 0.4468728 | 1.0000000 | 0.447 | NA | NA |
| G6PD | ponatinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| XPO1 | ponatinib | 0.5083316 | 1.0000000 | 0.508 | NA | NA |
| FGFR1 | ponatinib | 0.5160638 | 1.0000000 | 0.516 | NA | NA |
| VHL | ponatinib | 0.5393680 | 1.0000000 | 0.539 | NA | NA |
| CTLA4 | ponatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| IKZF1 | ponatinib | 0.5439933 | 1.0000000 | 0.544 | NA | NA |
| PDGFB | ponatinib | 0.5581846 | 1.0000000 | 0.558 | NA | NA |
| AKT3 | ponatinib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| ERBB4 | ponatinib | 0.5623068 | 1.0000000 | 0.562 | NA | NA |
| GNAS | ponatinib | 0.6057116 | 1.0000000 | 0.606 | NA | NA |
| ESR1 | ponatinib | 0.6098340 | 1.0000000 | 0.610 | NA | NA |
| SF3B1 | ponatinib | 0.6277256 | 1.0000000 | 0.628 | NA | NA |
| RUNX1 | ponatinib | 0.6352563 | 1.0000000 | 0.635 | NA | NA |
| CD79B | ponatinib | 0.6625206 | 1.0000000 | 0.663 | NA | NA |
| TET2 | ponatinib | 0.6650055 | 1.0000000 | 0.665 | NA | NA |
| WT1 | ponatinib | 0.6678058 | 1.0000000 | 0.668 | NA | NA |
| AR | ponatinib | 0.6956454 | 1.0000000 | 0.696 | NA | NA |
| SF1 | ponatinib | 0.6985354 | 1.0000000 | 0.699 | NA | NA |
| ABL1 | ponatinib | 0.7001804 | 1.0000000 | 0.700 | NA | NA |
| BRAF | ponatinib | 0.7089975 | 1.0000000 | 0.709 | NA | NA |
| MYD88 | ponatinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| HRAS | ponatinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| KMT2A | ponatinib | 0.7292187 | 1.0000000 | 0.729 | NA | NA |
| EML4 | ponatinib | 0.7372047 | 1.0000000 | 0.737 | NA | NA |
| CDK4 | ponatinib | 0.7373721 | 1.0000000 | 0.737 | NA | NA |
| PDGFRA | ponatinib | 0.7504890 | 1.0000000 | 0.750 | NA | NA |
| PRPF40B | ponatinib | 0.7549750 | 1.0000000 | 0.755 | NA | NA |
| GATA1 | ponatinib | 0.7687598 | 1.0000000 | 0.769 | NA | NA |
| DDIT3 | ponatinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| SRSF2 | ponatinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| NCOA2 | ponatinib | 0.7940027 | 1.0000000 | 0.794 | NA | NA |
| CXCR4 | ponatinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| DNAJB1 | ponatinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| EGFR | ponatinib | 0.8071948 | 1.0000000 | 0.807 | NA | NA |
| DNMT3A | ponatinib | 0.8077015 | 1.0000000 | 0.808 | NA | NA |
| CRLF2 | ponatinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| PAX5 | ponatinib | 0.8197075 | 1.0000000 | 0.820 | NA | NA |
| MET | ponatinib | 0.8335133 | 1.0000000 | 0.834 | NA | NA |
| MYCN | ponatinib | 0.8345316 | 1.0000000 | 0.835 | NA | NA |
| GATA3 | ponatinib | 0.8404030 | 1.0000000 | 0.840 | NA | NA |
| MGMT | ponatinib | 0.8464506 | 1.0000000 | 0.846 | NA | NA |
| ALK | ponatinib | 0.8510931 | 1.0000000 | 0.851 | NA | NA |
| TP53 | ponatinib | 0.8681882 | 1.0000000 | 0.868 | NA | NA |
| CREBBP | ponatinib | 0.8696111 | 1.0000000 | 0.870 | NA | NA |
| FLT3 | ponatinib | 0.8710999 | 1.0000000 | 0.871 | NA | NA |
| SMC1A | ponatinib | 0.8852339 | 1.0000000 | 0.885 | NA | NA |
| TSC2 | ponatinib | 0.8936686 | 1.0000000 | 0.894 | NA | NA |
| PRPF8 | ponatinib | 0.9203095 | 1.0000000 | 0.920 | NA | NA |
| FGFR2 | ponatinib | 0.9497712 | 1.0000000 | 0.950 | NA | NA |
| BCORL1 | ponatinib | 0.9769375 | 1.0000000 | 0.977 | NA | NA |
| FGFR3 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NPM1 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PTCH1 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MAP2K1 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| IDH1 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| KIT | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| JAK3 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BRCA1 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT2 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CBL | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ZRSR2 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| AKT1 | ponatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BCOR | sunitinib | 0.1051925 | 1.0000000 | 0.11 | NA | NA |
| GATA3 | sunitinib | 0.1535764 | 1.0000000 | 0.15 | NA | NA |
| SMC3 | sunitinib | 0.1588338 | 1.0000000 | 0.16 | NA | NA |
| KRAS | sunitinib | 0.1719754 | 1.0000000 | 0.17 | NA | NA |
| SETD2 | sunitinib | 0.1771126 | 1.0000000 | 0.18 | NA | NA |
| SETBP1 | sunitinib | 0.1994576 | 1.0000000 | 0.20 | NA | NA |
| KMT2A | sunitinib | 0.2027302 | 1.0000000 | 0.20 | NA | NA |
| EZH2 | sunitinib | 0.2112995 | 1.0000000 | 0.21 | NA | NA |
| TET2 | sunitinib | 0.2415666 | 1.0000000 | 0.24 | NA | NA |
| ZRSR2 | sunitinib | 0.2452781 | 1.0000000 | 0.25 | NA | NA |
| TP53 | sunitinib | 0.3081686 | 1.0000000 | 0.31 | NA | NA |
| CREBBP | sunitinib | 0.3607821 | 1.0000000 | 0.36 | NA | NA |
| ASXL1 | sunitinib | 0.3710934 | 1.0000000 | 0.37 | NA | NA |
| GNB1 | sunitinib | 0.3710934 | 1.0000000 | 0.37 | NA | NA |
| XPO1 | sunitinib | 0.3710934 | 1.0000000 | 0.37 | NA | NA |
| RET | sunitinib | 0.3710934 | 1.0000000 | 0.37 | NA | NA |
| BCORL1 | sunitinib | 0.3827331 | 1.0000000 | 0.38 | NA | NA |
| WT1 | sunitinib | 0.3864762 | 1.0000000 | 0.39 | NA | NA |
| STAG2 | sunitinib | 0.4532547 | 1.0000000 | 0.45 | NA | NA |
| PRPF8 | sunitinib | 0.4532547 | 1.0000000 | 0.45 | NA | NA |
| CDK4 | sunitinib | 0.4681599 | 1.0000000 | 0.47 | NA | NA |
| DPYD | sunitinib | 0.4681599 | 1.0000000 | 0.47 | NA | NA |
| NOTCH1 | sunitinib | 0.4767414 | 1.0000000 | 0.48 | NA | NA |
| FGFR3 | sunitinib | 0.4874533 | 1.0000000 | 0.49 | NA | NA |
| CALR | sunitinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| PDGFB | sunitinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| CD79B | sunitinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| PDGFRB | sunitinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| TSC1 | sunitinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| CTCF | sunitinib | 0.5524529 | 1.0000000 | 0.55 | NA | NA |
| ERBB4 | sunitinib | 0.5565355 | 1.0000000 | 0.56 | NA | NA |
| KIT | sunitinib | 0.5581846 | 1.0000000 | 0.56 | NA | NA |
| NRAS | sunitinib | 0.5623426 | 1.0000000 | 0.56 | NA | NA |
| ERBB3 | sunitinib | 0.5676354 | 1.0000000 | 0.57 | NA | NA |
| EGFR | sunitinib | 0.6170751 | 1.0000000 | 0.62 | NA | NA |
| VHL | sunitinib | 0.6373519 | 1.0000000 | 0.64 | NA | NA |
| FBXW7 | sunitinib | 0.6373519 | 1.0000000 | 0.64 | NA | NA |
| ROS1 | sunitinib | 0.6625206 | 1.0000000 | 0.66 | NA | NA |
| GNAS | sunitinib | 0.6926109 | 1.0000000 | 0.69 | NA | NA |
| FLT3 | sunitinib | 0.6985354 | 1.0000000 | 0.70 | NA | NA |
| ALK | sunitinib | 0.7147007 | 1.0000000 | 0.71 | NA | NA |
| CTNNB1 | sunitinib | 0.7236736 | 1.0000000 | 0.72 | NA | NA |
| STAT3 | sunitinib | 0.7236736 | 1.0000000 | 0.72 | NA | NA |
| IKZF1 | sunitinib | 0.7236736 | 1.0000000 | 0.72 | NA | NA |
| MET | sunitinib | 0.7236736 | 1.0000000 | 0.72 | NA | NA |
| PML | sunitinib | 0.7373721 | 1.0000000 | 0.74 | NA | NA |
| ATM | sunitinib | 0.7499077 | 1.0000000 | 0.75 | NA | NA |
| IL7R | sunitinib | 0.7728300 | 1.0000000 | 0.77 | NA | NA |
| FGFR2 | sunitinib | 0.7728300 | 1.0000000 | 0.77 | NA | NA |
| SF3B1 | sunitinib | 0.8025873 | 1.0000000 | 0.80 | NA | NA |
| WHSC1 | sunitinib | 0.8169613 | 1.0000000 | 0.82 | NA | NA |
| EML4 | sunitinib | 0.9089940 | 1.0000000 | 0.91 | NA | NA |
| PAX5 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| PTEN | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| GATA2 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| BRCA2 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| CBLB | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| G6PD | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| ABL1 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| PDGFRA | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| MYCN | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| NCOA2 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| AR | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| BRCA1 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| SF1 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| ERBB2 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| SMC1A | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| MGMT | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| PTCH1 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| NOTCH2 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| CBL | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| CRLF2 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| BTK | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| ETV6 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| FGFR1 | sunitinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| GNAS | lapatinib | 0.0851260 | 1.0000000 | 0.085 | NA | NA |
| NOTCH2 | lapatinib | 0.1051925 | 1.0000000 | 0.105 | NA | NA |
| TP53 | lapatinib | 0.1189502 | 1.0000000 | 0.119 | NA | NA |
| EGFR | lapatinib | 0.1336144 | 1.0000000 | 0.134 | NA | NA |
| NRAS | lapatinib | 0.1475014 | 1.0000000 | 0.148 | NA | NA |
| CBLB | lapatinib | 0.1752442 | 1.0000000 | 0.175 | NA | NA |
| SETD2 | lapatinib | 0.1771126 | 1.0000000 | 0.177 | NA | NA |
| AR | lapatinib | 0.1839855 | 1.0000000 | 0.184 | NA | NA |
| SF3B1 | lapatinib | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| KIT | lapatinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| TET2 | lapatinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| STAT3 | lapatinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| IKZF1 | lapatinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| PDGFRA | lapatinib | 0.3602164 | 1.0000000 | 0.360 | NA | NA |
| G6PD | lapatinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| MYCN | lapatinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| ASXL1 | lapatinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| GNB1 | lapatinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| ROS1 | lapatinib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| NCOA2 | lapatinib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| FGFR2 | lapatinib | 0.3864762 | 1.0000000 | 0.386 | NA | NA |
| NOTCH1 | lapatinib | 0.4064565 | 1.0000000 | 0.406 | NA | NA |
| ERBB3 | lapatinib | 0.4236225 | 1.0000000 | 0.424 | NA | NA |
| STAG2 | lapatinib | 0.4532547 | 1.0000000 | 0.453 | NA | NA |
| EZH2 | lapatinib | 0.4532547 | 1.0000000 | 0.453 | NA | NA |
| PRPF8 | lapatinib | 0.4532547 | 1.0000000 | 0.453 | NA | NA |
| BCORL1 | lapatinib | 0.4532547 | 1.0000000 | 0.453 | NA | NA |
| DPYD | lapatinib | 0.4681599 | 1.0000000 | 0.468 | NA | NA |
| GATA3 | lapatinib | 0.4755327 | 1.0000000 | 0.476 | NA | NA |
| WHSC1 | lapatinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| ABL1 | lapatinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| FGFR3 | lapatinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| BCOR | lapatinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| PDGFB | lapatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| PDGFRB | lapatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| MGMT | lapatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| ALK | lapatinib | 0.5532002 | 1.0000000 | 0.553 | NA | NA |
| VHL | lapatinib | 0.6373519 | 1.0000000 | 0.637 | NA | NA |
| SMC3 | lapatinib | 0.6385921 | 1.0000000 | 0.639 | NA | NA |
| KMT2A | lapatinib | 0.6480769 | 1.0000000 | 0.648 | NA | NA |
| PTEN | lapatinib | 0.6627994 | 1.0000000 | 0.663 | NA | NA |
| ZRSR2 | lapatinib | 0.6985354 | 1.0000000 | 0.699 | NA | NA |
| CTNNB1 | lapatinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| MET | lapatinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| EML4 | lapatinib | 0.7316568 | 1.0000000 | 0.732 | NA | NA |
| ATM | lapatinib | 0.7339383 | 1.0000000 | 0.734 | NA | NA |
| PML | lapatinib | 0.7373721 | 1.0000000 | 0.737 | NA | NA |
| IL7R | lapatinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| SETBP1 | lapatinib | 0.8306642 | 1.0000000 | 0.831 | NA | NA |
| CREBBP | lapatinib | 0.8549744 | 1.0000000 | 0.855 | NA | NA |
| PAX5 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| WT1 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA2 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BRCA2 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| KRAS | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CDK4 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BRCA1 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CALR | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SF1 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB4 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB2 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CD79B | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CTCF | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMC1A | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| XPO1 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PTCH1 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| TSC1 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FLT3 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| RET | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CBL | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CRLF2 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FBXW7 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BTK | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ETV6 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FGFR1 | lapatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ALK | dasatinib | 0.0443755 | 1.0000000 | 0.044 |
|
NA |
| KMT2A | dasatinib | 0.0507985 | 1.0000000 | 0.051 | NA | NA |
| GNAS | dasatinib | 0.0752537 | 1.0000000 | 0.075 | NA | NA |
| NOTCH2 | dasatinib | 0.1051925 | 1.0000000 | 0.105 | NA | NA |
| NRAS | dasatinib | 0.1475014 | 1.0000000 | 0.148 | NA | NA |
| SETD2 | dasatinib | 0.1771126 | 1.0000000 | 0.177 | NA | NA |
| AR | dasatinib | 0.1839855 | 1.0000000 | 0.184 | NA | NA |
| TET2 | dasatinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| FLT3 | dasatinib | 0.2452781 | 1.0000000 | 0.245 | NA | NA |
| ABL1 | dasatinib | 0.2471600 | 1.0000000 | 0.247 | NA | NA |
| BCOR | dasatinib | 0.2471600 | 1.0000000 | 0.247 | NA | NA |
| CTNNB1 | dasatinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| IKZF1 | dasatinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| MYCN | dasatinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| ASXL1 | dasatinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| XPO1 | dasatinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| RET | dasatinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| BCORL1 | dasatinib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| WT1 | dasatinib | 0.3864762 | 1.0000000 | 0.386 | NA | NA |
| EGFR | dasatinib | 0.4046568 | 1.0000000 | 0.405 | NA | NA |
| EML4 | dasatinib | 0.4236225 | 1.0000000 | 0.424 | NA | NA |
| SF3B1 | dasatinib | 0.4532547 | 1.0000000 | 0.453 | NA | NA |
| BRCA2 | dasatinib | 0.4567504 | 1.0000000 | 0.457 | NA | NA |
| DPYD | dasatinib | 0.4681599 | 1.0000000 | 0.468 | NA | NA |
| WHSC1 | dasatinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| KRAS | dasatinib | 0.5346942 | 1.0000000 | 0.535 | NA | NA |
| CALR | dasatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| PDGFB | dasatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| CD79B | dasatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| PDGFRB | dasatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| MGMT | dasatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| TSC1 | dasatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| CRLF2 | dasatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| BTK | dasatinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| CBLB | dasatinib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| PDGFRA | dasatinib | 0.5830249 | 1.0000000 | 0.583 | NA | NA |
| ATM | dasatinib | 0.5952328 | 1.0000000 | 0.595 | NA | NA |
| TP53 | dasatinib | 0.6343828 | 1.0000000 | 0.634 | NA | NA |
| VHL | dasatinib | 0.6373519 | 1.0000000 | 0.637 | NA | NA |
| FBXW7 | dasatinib | 0.6373519 | 1.0000000 | 0.637 | NA | NA |
| ROS1 | dasatinib | 0.6625206 | 1.0000000 | 0.663 | NA | NA |
| NCOA2 | dasatinib | 0.6625206 | 1.0000000 | 0.663 | NA | NA |
| CREBBP | dasatinib | 0.7147007 | 1.0000000 | 0.715 | NA | NA |
| BRCA1 | dasatinib | 0.7212767 | 1.0000000 | 0.721 | NA | NA |
| ERBB2 | dasatinib | 0.7212767 | 1.0000000 | 0.721 | NA | NA |
| GATA3 | dasatinib | 0.7212767 | 1.0000000 | 0.721 | NA | NA |
| STAT3 | dasatinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| MET | dasatinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| IL7R | dasatinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| FGFR2 | dasatinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| STAG2 | dasatinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| EZH2 | dasatinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| PRPF8 | dasatinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| NOTCH1 | dasatinib | 0.8125137 | 1.0000000 | 0.813 | NA | NA |
| PAX5 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PTEN | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMC3 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA2 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB3 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CDK4 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| G6PD | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| KIT | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PML | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FGFR3 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SF1 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GNB1 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB4 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CTCF | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMC1A | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PTCH1 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ZRSR2 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CBL | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SETBP1 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ETV6 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FGFR1 | dasatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ALK | imatinib | 0.0999747 | 1.0000000 | 0.10 | NA | NA |
| NRAS | imatinib | 0.1415789 | 1.0000000 | 0.14 | NA | NA |
| CREBBP | imatinib | 0.1436861 | 1.0000000 | 0.14 | NA | NA |
| FGFR2 | imatinib | 0.1489147 | 1.0000000 | 0.15 | NA | NA |
| ERBB2 | imatinib | 0.1535764 | 1.0000000 | 0.15 | NA | NA |
| SMC3 | imatinib | 0.1588338 | 1.0000000 | 0.16 | NA | NA |
| AR | imatinib | 0.1839855 | 1.0000000 | 0.18 | NA | NA |
| ATM | imatinib | 0.2022936 | 1.0000000 | 0.20 | NA | NA |
| KMT2A | imatinib | 0.2027302 | 1.0000000 | 0.20 | NA | NA |
| SF3B1 | imatinib | 0.2112995 | 1.0000000 | 0.21 | NA | NA |
| BRCA2 | imatinib | 0.2148469 | 1.0000000 | 0.21 | NA | NA |
| TET2 | imatinib | 0.2415666 | 1.0000000 | 0.24 | NA | NA |
| FLT3 | imatinib | 0.2452781 | 1.0000000 | 0.25 | NA | NA |
| BCOR | imatinib | 0.2471600 | 1.0000000 | 0.25 | NA | NA |
| TP53 | imatinib | 0.2481114 | 1.0000000 | 0.25 | NA | NA |
| KRAS | imatinib | 0.2637629 | 1.0000000 | 0.26 | NA | NA |
| GATA3 | imatinib | 0.2845027 | 1.0000000 | 0.28 | NA | NA |
| ASXL1 | imatinib | 0.2888444 | 1.0000000 | 0.29 | NA | NA |
| IKZF1 | imatinib | 0.2888444 | 1.0000000 | 0.29 | NA | NA |
| PTEN | imatinib | 0.3089378 | 1.0000000 | 0.31 | NA | NA |
| PML | imatinib | 0.3144127 | 1.0000000 | 0.31 | NA | NA |
| GNB1 | imatinib | 0.3710934 | 1.0000000 | 0.37 | NA | NA |
| RET | imatinib | 0.3710934 | 1.0000000 | 0.37 | NA | NA |
| NCOA2 | imatinib | 0.3827331 | 1.0000000 | 0.38 | NA | NA |
| WT1 | imatinib | 0.3864762 | 1.0000000 | 0.39 | NA | NA |
| PRPF8 | imatinib | 0.4532547 | 1.0000000 | 0.45 | NA | NA |
| DPYD | imatinib | 0.4681599 | 1.0000000 | 0.47 | NA | NA |
| BRCA1 | imatinib | 0.4755327 | 1.0000000 | 0.48 | NA | NA |
| WHSC1 | imatinib | 0.4874533 | 1.0000000 | 0.49 | NA | NA |
| FGFR3 | imatinib | 0.4874533 | 1.0000000 | 0.49 | NA | NA |
| NOTCH2 | imatinib | 0.4874533 | 1.0000000 | 0.49 | NA | NA |
| CALR | imatinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| PDGFB | imatinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| TSC1 | imatinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| CRLF2 | imatinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| BTK | imatinib | 0.5402914 | 1.0000000 | 0.54 | NA | NA |
| GNAS | imatinib | 0.5532002 | 1.0000000 | 0.55 | NA | NA |
| ERBB4 | imatinib | 0.5565355 | 1.0000000 | 0.56 | NA | NA |
| EML4 | imatinib | 0.5676354 | 1.0000000 | 0.57 | NA | NA |
| VHL | imatinib | 0.6373519 | 1.0000000 | 0.64 | NA | NA |
| FBXW7 | imatinib | 0.6373519 | 1.0000000 | 0.64 | NA | NA |
| ROS1 | imatinib | 0.6625206 | 1.0000000 | 0.66 | NA | NA |
| BCORL1 | imatinib | 0.6625206 | 1.0000000 | 0.66 | NA | NA |
| ZRSR2 | imatinib | 0.6985354 | 1.0000000 | 0.70 | NA | NA |
| CTNNB1 | imatinib | 0.7236736 | 1.0000000 | 0.72 | NA | NA |
| STAT3 | imatinib | 0.7236736 | 1.0000000 | 0.72 | NA | NA |
| MET | imatinib | 0.7236736 | 1.0000000 | 0.72 | NA | NA |
| IL7R | imatinib | 0.7728300 | 1.0000000 | 0.77 | NA | NA |
| SETBP1 | imatinib | 0.8306642 | 1.0000000 | 0.83 | NA | NA |
| CBLB | imatinib | 0.8464506 | 1.0000000 | 0.85 | NA | NA |
| EGFR | imatinib | 0.8676323 | 1.0000000 | 0.87 | NA | NA |
| SETD2 | imatinib | 0.8807910 | 1.0000000 | 0.88 | NA | NA |
| PAX5 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| GATA2 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| ERBB3 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| CDK4 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| G6PD | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| ABL1 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| KIT | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| STAG2 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| EZH2 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| NOTCH1 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| PDGFRA | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| MYCN | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| SF1 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| CD79B | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| PDGFRB | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| CTCF | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| SMC1A | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| XPO1 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| MGMT | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| PTCH1 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| CBL | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| ETV6 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| FGFR1 | imatinib | 1.0000000 | 1.0000000 | 1.00 | NA | NA |
| ALK | erlotinib | 0.0752537 | 1.0000000 | 0.075 | NA | NA |
| TP53 | erlotinib | 0.1403572 | 1.0000000 | 0.140 | NA | NA |
| ATM | erlotinib | 0.1453139 | 1.0000000 | 0.145 | NA | NA |
| NRAS | erlotinib | 0.1637344 | 1.0000000 | 0.164 | NA | NA |
| SF3B1 | erlotinib | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| KIT | erlotinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| NOTCH2 | erlotinib | 0.2452781 | 1.0000000 | 0.245 | NA | NA |
| FGFR2 | erlotinib | 0.2452781 | 1.0000000 | 0.245 | NA | NA |
| FGFR3 | erlotinib | 0.2471600 | 1.0000000 | 0.247 | NA | NA |
| NOTCH1 | erlotinib | 0.2781564 | 1.0000000 | 0.278 | NA | NA |
| TET2 | erlotinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| AR | erlotinib | 0.3014437 | 1.0000000 | 0.301 | NA | NA |
| CREBBP | erlotinib | 0.3230126 | 1.0000000 | 0.323 | NA | NA |
| CBLB | erlotinib | 0.3329216 | 1.0000000 | 0.333 | NA | NA |
| GATA3 | erlotinib | 0.3475580 | 1.0000000 | 0.348 | NA | NA |
| PDGFRA | erlotinib | 0.3602164 | 1.0000000 | 0.360 | NA | NA |
| IL7R | erlotinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| ASXL1 | erlotinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| ROS1 | erlotinib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| NCOA2 | erlotinib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| WT1 | erlotinib | 0.3864762 | 1.0000000 | 0.386 | NA | NA |
| PML | erlotinib | 0.4344457 | 1.0000000 | 0.434 | NA | NA |
| SETD2 | erlotinib | 0.4755327 | 1.0000000 | 0.476 | NA | NA |
| ABL1 | erlotinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| KMT2A | erlotinib | 0.4896603 | 1.0000000 | 0.490 | NA | NA |
| GNAS | erlotinib | 0.5185170 | 1.0000000 | 0.519 | NA | NA |
| CD79B | erlotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| MGMT | erlotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| FLT3 | erlotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| BCORL1 | erlotinib | 0.5581846 | 1.0000000 | 0.558 | NA | NA |
| VHL | erlotinib | 0.6373519 | 1.0000000 | 0.637 | NA | NA |
| CTNNB1 | erlotinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| KRAS | erlotinib | 0.7889848 | 1.0000000 | 0.789 | NA | NA |
| ERBB4 | erlotinib | 0.8025873 | 1.0000000 | 0.803 | NA | NA |
| EGFR | erlotinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| BRCA1 | erlotinib | 0.8247781 | 1.0000000 | 0.825 | NA | NA |
| ERBB2 | erlotinib | 0.8247781 | 1.0000000 | 0.825 | NA | NA |
| SETBP1 | erlotinib | 0.8807910 | 1.0000000 | 0.881 | NA | NA |
| PTEN | erlotinib | 0.8844342 | 1.0000000 | 0.884 | NA | NA |
| BRCA2 | erlotinib | 0.8936947 | 1.0000000 | 0.894 | NA | NA |
| PAX5 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMC3 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| WHSC1 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA2 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB3 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CDK4 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| STAG2 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MYCN | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CALR | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SF1 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GNB1 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| EML4 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BCOR | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| G6PD | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CTCF | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMC1A | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| XPO1 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PTCH1 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| IKZF1 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| TSC1 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ZRSR2 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| RET | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CBL | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MET | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CRLF2 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ETV6 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BTK | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FGFR1 | erlotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ERBB3 | crizotinib | 0.0519887 | 1.0000000 | 0.052 | NA | NA |
| NOTCH1 | crizotinib | 0.1547052 | 1.0000000 | 0.155 | NA | NA |
| AR | crizotinib | 0.1839855 | 1.0000000 | 0.184 | NA | NA |
| NCOA2 | crizotinib | 0.1904303 | 1.0000000 | 0.190 | NA | NA |
| SETBP1 | crizotinib | 0.1994576 | 1.0000000 | 0.199 | NA | NA |
| STAG2 | crizotinib | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| EZH2 | crizotinib | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| SF3B1 | crizotinib | 0.2112995 | 1.0000000 | 0.211 | NA | NA |
| CTCF | crizotinib | 0.2347637 | 1.0000000 | 0.235 | NA | NA |
| TET2 | crizotinib | 0.2415666 | 1.0000000 | 0.242 | NA | NA |
| FLT3 | crizotinib | 0.2452781 | 1.0000000 | 0.245 | NA | NA |
| CTNNB1 | crizotinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| STAT3 | crizotinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| ASXL1 | crizotinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| MET | crizotinib | 0.2888444 | 1.0000000 | 0.289 | NA | NA |
| EML4 | crizotinib | 0.3035890 | 1.0000000 | 0.304 | NA | NA |
| NRAS | crizotinib | 0.3495748 | 1.0000000 | 0.350 | NA | NA |
| GNB1 | crizotinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| XPO1 | crizotinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| ETV6 | crizotinib | 0.3710934 | 1.0000000 | 0.371 | NA | NA |
| BCORL1 | crizotinib | 0.3827331 | 1.0000000 | 0.383 | NA | NA |
| KRAS | crizotinib | 0.3847384 | 1.0000000 | 0.385 | NA | NA |
| PRPF8 | crizotinib | 0.4532547 | 1.0000000 | 0.453 | NA | NA |
| PDGFRA | crizotinib | 0.4641916 | 1.0000000 | 0.464 | NA | NA |
| GATA3 | crizotinib | 0.4755327 | 1.0000000 | 0.476 | NA | NA |
| FGFR3 | crizotinib | 0.4874533 | 1.0000000 | 0.487 | NA | NA |
| CALR | crizotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| PDGFB | crizotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| CD79B | crizotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| PDGFRB | crizotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| TSC1 | crizotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| BTK | crizotinib | 0.5402914 | 1.0000000 | 0.540 | NA | NA |
| TP53 | crizotinib | 0.5409061 | 1.0000000 | 0.541 | NA | NA |
| KMT2A | crizotinib | 0.5522142 | 1.0000000 | 0.552 | NA | NA |
| GNAS | crizotinib | 0.5532002 | 1.0000000 | 0.553 | NA | NA |
| KIT | crizotinib | 0.5581846 | 1.0000000 | 0.558 | NA | NA |
| CBLB | crizotinib | 0.5612758 | 1.0000000 | 0.561 | NA | NA |
| EGFR | crizotinib | 0.6170751 | 1.0000000 | 0.617 | NA | NA |
| FBXW7 | crizotinib | 0.6373519 | 1.0000000 | 0.637 | NA | NA |
| SMC3 | crizotinib | 0.6385921 | 1.0000000 | 0.639 | NA | NA |
| SETD2 | crizotinib | 0.6527828 | 1.0000000 | 0.653 | NA | NA |
| ATM | crizotinib | 0.6708259 | 1.0000000 | 0.671 | NA | NA |
| ERBB2 | crizotinib | 0.7212767 | 1.0000000 | 0.721 | NA | NA |
| IKZF1 | crizotinib | 0.7236736 | 1.0000000 | 0.724 | NA | NA |
| ERBB4 | crizotinib | 0.7687598 | 1.0000000 | 0.769 | NA | NA |
| WT1 | crizotinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| FGFR2 | crizotinib | 0.7728300 | 1.0000000 | 0.773 | NA | NA |
| WHSC1 | crizotinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| ABL1 | crizotinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| BCOR | crizotinib | 0.8169613 | 1.0000000 | 0.817 | NA | NA |
| PTEN | crizotinib | 0.8844342 | 1.0000000 | 0.884 | NA | NA |
| PAX5 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ROS1 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| IL7R | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| GATA2 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ALK | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BRCA2 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CREBBP | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CDK4 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| G6PD | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MYCN | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PML | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| BRCA1 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| DPYD | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SF1 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| VHL | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| SMC1A | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| MGMT | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| PTCH1 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| NOTCH2 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| ZRSR2 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| RET | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CBL | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| CRLF2 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
| FGFR1 | crizotinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
wilcox_gdsc_gene_lvlA_plot <- ggplot(data = gdsc_signif_lvlA) +
geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gdsc_gene_lvlA_plot
Mutation status boxplots for genes identified in G2P.
genes_lvlA_filt <- c("KRAS", "EGFR", "MET", "ALK", "BRAF", "ERBB2", "ABL1", "ROS1", "KIT", "DPYD", "PDGFRA", "RET", "BRCA1", "UGT1A1", "IDH2", "ESR1", "TPMT", "BRCA2", "PDGFRB", "G6PD", "PML", "TSC1", "FLT3", "ERBB3", "CYP19A1", "AKT1", "PTCH1", "MGMT", "DNMT3A", "MYD88", "PDGFB", "TSC2", "NPM1", "JAK2")
crispr_ptmuts_lvlA_filt <- filter(crispr_data_ptmuts, Hugo_Symbol %in% genes_lvlA_filt)
crispr_ptmuts_lvlA_filt$Hugo_Symbol <- ordered(crispr_ptmuts_lvlA_filt$Hugo_Symbol, levels = genes_lvlA_filt)
crispr_ptmuts_lvlA_filt_color <- as.character(crispr_ptmuts_lvlA_filt$Color_Nonsilent)
names(crispr_ptmuts_lvlA_filt_color) <- crispr_ptmuts_lvlA_filt$Mutation_Status_Nonsilent
label_text <- data.frame(p.signif.adj = crispr_signif_lvlA$p.signif.adj, Hugo_Symbol = crispr_signif_lvlA$Hugo_Symbol)
label_text <- filter(label_text, Hugo_Symbol %in% genes_lvlA_filt)
label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = genes_lvlA_filt)
crispr_ptmuts_lvlA_filt_plot_faceted <- ggplot(data = crispr_ptmuts_lvlA_filt, aes(x = Mutation_Status_Nonsilent, y = Score)) +
facet_wrap(~ Hugo_Symbol, drop = FALSE, ncol = length(genes_lvlA)) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85)) +
scale_fill_manual(values = crispr_ptmuts_lvlA_filt_color) +
guides(color = FALSE) +
geom_text(data = label_text, mapping = aes(x = 1.5, y = 2, label = p.signif.adj)) +
theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
labs(fill = "Mutation Status", y = "CERES Score", x = "Mutation Status")
crispr_ptmuts_lvlA_filt_plot_faceted
# ggsave("./plots_18Q3/manuscript/crispr_ptmuts_lvlA_filt_plot_faceted.png", crispr_ptmuts_lvlA_filt_plot_faceted, device = "png", dpi = 450, width = 20, height = 4, units = "in")
ccle_ptmuts_lvlA_filt <- filter(ccle_data_ptmuts, Hugo_Symbol %in% genes_lvlA_filt)
ccle_ptmuts_lvlA_filt$Hugo_Symbol <- ordered(ccle_ptmuts_lvlA_filt$Hugo_Symbol, levels = genes_lvlA_filt)
ccle_drugs <- as.character(unique(ccle_ptmuts_lvlA_filt$Drug))
Plot code:
ccle_lvlA_drugboxplots <- lapply(ccle_drugs, makeDrugBoxplots, dataset = "CCLE")
ccle_lvlA_drugboxplot_paths <- paste0(ccle_drugs, "_ccle_boxplots.png")
pwalk(list(ccle_lvlA_drugboxplot_paths, ccle_lvlA_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/ccle_lvlA_boxplots", dpi = 450, width = 20, height = 4, units = "in")
Data management:
ccle_lvlA_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/ccle_lvlA_boxplots", full.names = TRUE))
names(ccle_lvlA_drugboxplots) <- str_replace_all(ccle_lvlA_drugboxplots, c("_ccle_boxplots.png" = "", "./plots_18Q3/manuscript/ccle_lvlA_boxplots/" = ""))
bsselect(ccle_lvlA_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)
ctrp_ptmuts_lvlA_filt <- filter(ctrp_data_ptmuts, Hugo_Symbol %in% genes_lvlA_filt)
ctrp_ptmuts_lvlA_filt$Hugo_Symbol <- ordered(ctrp_ptmuts_lvlA_filt$Hugo_Symbol, levels = genes_lvlA_filt)
ctrp_drugs <- as.character(unique(ctrp_ptmuts_lvlA_filt$Drug))
Plot code:
ctrp_lvlA_drugboxplots <- lapply(ctrp_drugs, makeDrugBoxplots, dataset = "CTRP")
ctrp_lvlA_drugboxplot_paths <- paste0(ctrp_drugs, "_ctrp_boxplots.png")
pwalk(list(ctrp_lvlA_drugboxplot_paths, ctrp_lvlA_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/ctrp_lvlA_boxplots", dpi = 450, width = 20, height = 4, units = "in")
Data management:
ctrp_lvlA_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/ctrp_lvlA_boxplots", full.names = TRUE))
names(ctrp_lvlA_drugboxplots) <- str_replace_all(ctrp_lvlA_drugboxplots, c("_ctrp_boxplots.png" = "", "./plots_18Q3/manuscript/ctrp_lvlA_boxplots/" = ""))
bsselect(ctrp_lvlA_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)
gdsc_ptmuts_lvlA_filt <- filter(gdsc_data_ptmuts, Hugo_Symbol %in% genes_lvlA_filt)
gdsc_ptmuts_lvlA_filt$Hugo_Symbol <- ordered(gdsc_ptmuts_lvlA_filt$Hugo_Symbol, levels = genes_lvlA_filt)
gdsc_drugs <- as.character(unique(gdsc_ptmuts_lvlA_filt$Drug))
Plot code:
gdsc_lvlA_drugboxplots <- lapply(gdsc_drugs, makeDrugBoxplots, dataset = "GDSC")
gdsc_lvlA_drugboxplot_paths <- paste0(gdsc_drugs, "_gdsc_boxplots.png")
pwalk(list(gdsc_lvlA_drugboxplot_paths, gdsc_lvlA_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/gdsc_lvlA_boxplots", dpi = 450, width = 20, height = 4, units = "in")
Data management:
gdsc_lvlA_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/gdsc_lvlA_boxplots", full.names = TRUE))
names(gdsc_lvlA_drugboxplots) <- str_replace_all(gdsc_lvlA_drugboxplots, c("_gdsc_boxplots.png" = "", "./plots_18Q3/manuscript/gdsc_lvlA_boxplots/" = ""))
bsselect(gdsc_lvlA_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)
Match specific point mutations.
g2p_indications <- filter(read.delim("./data_munging/data_mutation_associations_appended.csv", sep = "\t", header = TRUE), Evidence.Level == "A")
maf_g2p_indications <- filter(maf_raw, Genome_Change %in% g2p_indications$MutationName)
crispr_g2p_indications <- merge(maf_g2p_indications, crispr_data_ptmuts, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"))
dup_g2p_indications <- filter(crispr_g2p_indications[, c("Hugo_Symbol", "CCLE_Name", "Broad_ID")] %>% group_by(Hugo_Symbol, CCLE_Name, Broad_ID) %>% tally(), n > 1)
crispr_g2p_indications <- merge(crispr_g2p_indications, dup_g2p_indications, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)
crispr_g2p_indications <- filter(crispr_g2p_indications, is.na(n))
crispr_g2p_indications_plot <- ggplot(crispr_g2p_indications, aes(x = Hugo_Symbol, y = Score)) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(alpha = 0.5, color = "lightgray", outlier.shape = NA) +
geom_jitter(width = 0.3, mapping = aes(color = group_general_lineage_name), size = 1) +
theme_light() +
theme(legend.title = element_blank()) +
labs(x = "Gene", y = "CERES Score")
crispr_g2p_indications_plot
crispr_g2p_indications_muts_plot <- ggplot(crispr_g2p_indications, aes(x = Protein_Change, y = Score)) +
facet_grid(~ Hugo_Symbol, scales = "free_x", space = "free") +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(alpha = 0.5, color = "lightgray", outlier.shape = NA) +
geom_jitter(width = 0.1, mapping = aes(color = group_general_lineage_name), size = 1) +
theme_light() +
theme(legend.title = element_blank(), axis.text.x = element_text(angle = 90, hjust = 1)) +
labs(x = "Gene", y = "CERES Score")
crispr_g2p_indications_muts_plot
# ggsave("./plots_18Q3/manuscript/crispr_g2p_indications_plot_test.png", crispr_g2p_indications_plot, width = 12, height = 5, units = "in")
# ggsave("./plots_18Q3/manuscript/crispr_g2p_indications_muts_plot_test.png", crispr_g2p_indications_muts_plot, width = 20, height = 5, units = "in")
Plot code:
crispr_lvlA_groups <- lapply(as.character(genes_lvlA), makeCRISPRgrob, filt_method = "lvlA")
crispr_lvlA_groups_paths <- paste0(genes_lvlA, "_crispr_grouped.png")
pwalk(list(crispr_lvlA_groups_paths, crispr_lvlA_groups), ggsave, path = "./plots_18Q3/crispr_grouped_plots_lvlA", dpi = 300, width = 12, height = 12, units = "in")
Data management:
crispr_lvlA_bygene <- paste0(list.files("./plots_18Q3/crispr_grouped_plots_lvlA", full.names = TRUE))
names(crispr_lvlA_bygene) <- str_replace_all(crispr_lvlA_bygene, c("_crispr_grouped.png" = "", "./plots_18Q3/crispr_grouped_plots_lvlA/" = ""))
crispr_lvlA_order <- c(intersect(crispr_signif_lvlA$Hugo_Symbol, names(crispr_lvlA_bygene)), setdiff(names(crispr_lvlA_bygene), crispr_signif_lvlA$Hugo_Symbol))
crispr_lvlA_bygene <- crispr_lvlA_bygene[match(crispr_lvlA_order, names(crispr_lvlA_bygene))]
bsselect(crispr_lvlA_bygene, type = "img", selected = "KRAS", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)
g2pA <- read.delim("./data_munging/g2p_full_level_A_dataset_v2_10_10_2018.csv", sep = "\t", header = TRUE, na.strings = "-1", quote = "")
# g2pA[g2pA == "-1"] <- NA
g2pA$X <- NULL
g2pA_JSON <- data.frame(JSON = g2pA$JSON)
g2pA_noJSON <- g2pA
g2pA_noJSON$JSON <- NULL
# write.table(g2pA, file = "./data_munging/g2p_full_level_A_dataset_v2_10_10_2018.tsv", quote = FALSE, sep = "\t", row.names = FALSE)
# write.table(g2pA_noJSON, file = "./data_munging/g2pA_noJSON_v2_10_10_2018.tsv", quote = FALSE, sep = "\t", row.names = FALSE)
# write.table(g2pA_JSON, file = "./data_munging/g2pA_JSON_v2_10_10_2018.tsv", quote = FALSE, sep = "\t", row.names = FALSE)
{
'feature_names': 'ALK positive',
'jax': '{\"responseType\": \"sensitive\",
\"efficacyEvidence\": \"Zykadia (ceritinib) is FDA approved for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) in patients previously treated with crizotinib (FDA.gov).\",
\"molecularProfile\": {\"profileName\": \"ALK positive\",
\"id\": 1772},
\"evidenceType\": \"Actionable\",
\"indication\": {\"source\": \"DOID\",
\"id\": 3908,
\"name\": \"non-small cell lung carcinoma\"},
\"references\": [{\"url\": \"http://www.fda.gov/\",
\"id\": 286,
\"pubMedId\": null,
\"title\": \"FDA.gov\"}],
\"approvalStatus\": \"FDA approved\",
\"therapy\": {\"id\": 789,
\"therapyName\": \"Ceritinib\"},
\"id\": 1481}',
'tags': [],
'genes': ['ALK'],
'source_url': 'https://ckb.jax.org/therapy/show/789',
'source': 'jax',
'dev_tags': [],
'gene_identifiers': [{'symbol': 'ALK',
'entrez_id': '238',
'ensembl_gene_id': 'ENSG00000171094'}],
'association': {'drug_labels': 'CERITINIB',
'description': 'Zykadia (ceritinib) is FDA approved for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) in patients previously treated with crizotinib (FDA.gov).',
'publication_url': 'http://www.fda.gov/',
'source_link': 'https://ckb.jax.org/molecularProfile/show/1772',
'variant_name': [''],
'phenotypes': [{'source': 'http://purl.obolibrary.org/obo/DOID_3908',
'term': 'non-small cell lung carcinoma',
'description': 'non-small cell lung carcinoma',
'family': 'lung cancer',
'id': 'DOID:3908'}],
'evidence': [{'info': {'publications': ['http://www.fda.gov/']},
'evidenceType': {'sourceName': 'jax'},
'description': 'sensitive'}],
'environmentalContexts': [{'term': 'CERITINIB',
'description': 'CERITINIB',
'taxonomy': {'kingdom': 'Chemical entities',
'direct-parent': 'Phenylpiperidines',
'class': 'Organoheterocyclic compounds',
'subclass': 'Piperidines',
'superclass': 'Organic compounds'},
'source': 'http://rdf.ncbi.nlm.nih.gov/pubchem/compound',
'usan_stem': 'tyrosine kinase inhibitors',
'toxicity': 'There is not currently any data on carcinogenicity, effect on human fertility, or on early embryonic development. However, based on its mechanism of action, ceritinib may cause fetal harm when administered to pregnant women and should therefore be administered with effective contraception during treatment. Diarrhea, nausea, vomiting, or abdominal pain occurred in 96% of 255 patients including severe cases in 14% of patients. Drug-induced hepatotoxicity also occurred in 27% of 255 patients, presenting as alanine aminotransferase (ALT) levels greater than 5 times the upper limit of normal (ULN). Severe, life-threatening, or fatal interstitial lung disease (ILD)/pneumonitis, hyperglycaemia, and bradycardia have also been reported.',
'approved_countries': ['Canada',
'US'],
'id': 'CID57379345'}],
'evidence_label': 'A',
'response_type': 'sensitive',
'evidence_level': 1},
'features': [{'provenance_rule': 'default_feature',
'end': 29484957,
'description': 'ALK positive',
'links': ['http://reg.genome.network/refseq/RS000050',
'http://reg.genome.network/refseq/RS000026',
'http://reg.genome.network/allele/CA425438613',
'http://reg.genome.network/refseq/RS000002',
'http://myvariant.info/v1/variant/chr2:g.29484957C>G?assembly=hg19',
'http://reg.genome.network/refseq/RS001597'],
'sequence_ontology': {'hierarchy': ['SO:0000400',
'SO:0000733',
'SO:0000401',
'SO:0000119',
'SO:0000123',
'SO:0000125'],
'soid': 'SO:0000475',
'root_name': 'sequence_attribute',
'name': 'positively_autoregulated',
'root_soid': 'SO:0000400'},
'provenance': ['http://myvariant.info/v1/query?q=ALK positive',
'http://reg.genome.network/allele?hgvs=NC_000002.11%3Ag.29484957C%3EG'],
'start': 29484957,
'synonyms': ['NC_000002.11:g.29484957C>G',
'NC_000002.10:g.29338461C>G',
'LRG_488:g.664476G>C',
'chr2:g.29484957C>G',
'NG_009445.1:g.664476G>C',
'NC_000002.12:g.29262091C>G',
'CM000664.1:g.29484957C>G',
'CM000664.2:g.29262091C>G'],
'biomarker_type': 'positive',
'referenceName': 'GRCh37',
'geneSymbol': 'ALK',
'alt': 'G',
'ref': 'C',
'chromosome': '2',
'name': 'ALK positive'}]
}
The mutation status portion of these heatmaps was made using deleterious and missense mutations as “mutant” and all others as “other.”
Make and save heatmap data matrices:
# Set up heatmap data
chm_scores <- t(crispr)
colnames(chm_scores) <- chm_scores[1, ]
chm_scores <- chm_scores[-1, ]
chm_rows <- rownames(chm_scores)
chm_cols <- colnames(chm_scores)
chm_scores <- apply(chm_scores, 2, as.double)
chm_scores <- apply(chm_scores, 2, function(x) (x - mean(x)) / var(x))
colnames(chm_scores) <- chm_cols
rownames(chm_scores) <- chm_rows
saveRDS(chm_scores, "./data_munging/rds/crispr_heatmap_scores.rds")
# Make full grid for genomic features
crispr_grid_ccls <- unique(crispr_data$Broad_ID)
crispr_grid_genes <- unique(crispr_data$Hugo_Symbol)
crispr_grid <- expand.grid("Broad_ID" = crispr_grid_ccls, "Hugo_Symbol" = crispr_grid_genes)
# Gene expression
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))[, c("Hugo_Symbol", "Broad_ID", "RPKM")]
ge_filt$RPKM <- log2(ge_filt$RPKM + 0.0001)
chm_ge_grid <- merge(crispr_grid, ge_filt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
chm_ge <- reshape(chm_ge_grid, idvar = "Hugo_Symbol", timevar = "Broad_ID", direction = "wide")
chm_ge_rows <- chm_ge$Hugo_Symbol
chm_ge$Hugo_Symbol <- NULL
chm_ge_cols <- colnames(chm_ge) %>% gsub("RPKM.", "", .)
chm_ge <- apply(chm_ge, 2, as.double)
chm_ge <- apply(chm_ge, 2, function(x) (x - mean(x, na.rm = TRUE)) / var(x, na.rm = TRUE))
rownames(chm_ge) <- chm_ge_rows
colnames(chm_ge) <- chm_ge_cols
saveRDS(chm_ge, "./data_munging/rds/crispr_heatmap_ge.rds")
# Mutation status
chm_mut_grid <- merge(crispr_grid, maf_df[, c("Broad_ID", "Hugo_Symbol", "Mutation_Status")], by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
chm_mut_grid$Mutation_Status <- ifelse(is.na(chm_mut_grid$Mutation_Status), "Other", chm_mut_grid$Mutation_Status)
chm_mut_grid$Mutation_Status <- ifelse(chm_mut_grid$Mutation_Status == "Other", 0, 1)
chm_mut <- reshape(chm_mut_grid, idvar = "Hugo_Symbol", timevar = "Broad_ID", direction = "wide")
chm_mut_rows <- chm_mut$Hugo_Symbol
chm_mut$Hugo_Symbol <- NULL
chm_mut_cols <- colnames(chm_mut) %>% gsub("Mutation_Status.", "", .)
chm_mut <- matrix(as.numeric(unlist(chm_mut)), nrow = nrow(chm_mut))
rownames(chm_mut) <- chm_mut_rows
colnames(chm_mut) <- chm_mut_cols
saveRDS(chm_mut, "./data_munging/rds/crispr_heatmap_mut.rds")
# Copy number
cn_filt <- filter(cn_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))
chm_cn_grid <- merge(crispr_grid, cn_melt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
chm_cn <- reshape(chm_cn_grid, idvar = "Hugo_Symbol", timevar = "Broad_ID", direction = "wide")
chm_cn_rows <- chm_cn$Hugo_Symbol
chm_cn$Hugo_Symbol <- NULL
chm_cn_cols <- colnames(chm_cn) %>% gsub("Copy_Number.", "", .)
chm_cn <- apply(chm_cn, 2, as.double)
chm_cn <- apply(chm_cn, 2, function(x) (x - mean(x, na.rm = TRUE)) / var(x, na.rm = TRUE))
rownames(chm_cn) <- chm_cn_rows
colnames(chm_cn) <- chm_cn_cols
saveRDS(chm_cn, "./data_munging/rds/crispr_heatmap_cn.rds")
Load heatmap matrices:
chm_scores <- readRDS("./data_munging/rds/crispr_heatmap_scores.rds")
chm_ge <- readRDS("./data_munging/rds/crispr_heatmap_ge.rds")
chm_mut <- readRDS("./data_munging/rds/crispr_heatmap_mut.rds")
chm_cn <- readRDS("./data_munging/rds/crispr_heatmap_cn.rds")
# Metadata anotation dataframe
chm_annot <- merge(merge(data.frame("Broad_ID" = crispr$Broad_ID), crispr_meta[, c("Broad_ID", "cell_line_SSMD", "cas9_activity", "culture_type", "primary_tissue")], by = "Broad_ID", all.x = TRUE), ccl_info[, c("Broad_ID", "Primary.Disease", "Gender", "Source")], by = "Broad_ID", all.x = TRUE)
rownames(chm_annot) <- chm_annot$Broad_ID
chm_annot$Broad_ID <- NULL
colnames(chm_annot) <- c("Cell_Line_SSMD", "Cas9_Activity", "Culture_Type", "Primary_Tissue", "Primary_Disease", "Gender", "Source")
chm_annot$Cell_Line_SSMD <- as.numeric(chm_annot$Cell_Line_SSMD)
chm_annot$Cas9_Activity <- as.numeric(chm_annot$Cas9_Activity)
chm_annot_list <- HeatmapAnnotation(df = chm_annot, annotation_legend_param = list(
Cell_Line_SSMD = list(title = "Cell Line SSMD", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
Cas9_Activity = list(title = "Cas9 Activity", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
Culture_Type = list(title = "Culture Type", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Culture Type", title_position = "topleft", grid_height = unit(0.3, "in")),
Primary_Tissue = list(title = "Primary Tissue", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary_Tissue", title_position = "topleft", grid_height = unit(0.3, "in")),
Primary_Disease = list(title = "Primary Disease", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary Disease", title_position = "topleft", grid_height = unit(0.3, "in")),
Gender = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), grid_height = unit(0.3, "in")),
Source = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Source", title_position = "topleft", grid_height = unit(0.3, "in"))))
chm_all_plot <- Heatmap(chm_scores, name = "CERES Score",
bottom_annotation = chm_annot_list,
bottom_annotation_height = unit(5, "in"),
heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
row_title = "Genes", column_title = "Cancer Cell Lines",
col = colorRamp2(c(min(chm_scores), 0, max(chm_scores)), c("purple4", "white", "seagreen4")),
na_col = "black",
row_title_gp = gpar(fontsize = 30, fontface = "bold"),
row_names_gp = gpar(fontsize = 5),
column_title_gp = gpar(fontsize = 30, fontface = "bold"),
column_names_gp = gpar(fontsize = 5),
row_dend_reorder = TRUE,
column_dend_reorder = TRUE,
clustering_distance_rows = "euclidean",
clustering_distance_columns = "euclidean",
clustering_method_rows = "complete",
clustering_method_columns = "complete",
column_dend_height = unit(2, "in"),
row_dend_width = unit(4, "in"),
width = 3)
pdf("./plots_18Q3/crispr_heatmap_euclidean_all.pdf", width = 50, height = 50, paper = "special")
draw(chm_all_plot, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()
png("./plots_18Q3/crispr_heatmap_euclidean_all.png", width = 50, height = 50, units = "in", res = 96)
draw(chm_all_plot, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()
Code for heatmap of CGC-filtered genes only
chm_scores_cgc <- subset(chm_scores, rownames(chm_scores) %in% cgc$Hugo_Symbol)
chm_ge_cgc <- subset(chm_ge, rownames(chm_ge) %in% cgc$Hugo_Symbol)
chm_mut_cgc <- subset(chm_mut, rownames(chm_mut) %in% cgc$Hugo_Symbol)
chm_cn_cgc <- subset(chm_cn, rownames(chm_cn) %in% cgc$Hugo_Symbol)
chm_annot_list <- HeatmapAnnotation(df = chm_annot, annotation_legend_param = list(
Cell_Line_SSMD = list(title = "Cell Line SSMD", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
Cas9_Activity = list(title = "Cas9 Activity", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
Culture_Type = list(title = "Culture Type", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Culture Type", title_position = "topleft", grid_height = unit(0.3, "in")),
Primary_Tissue = list(title = "Primary Tissue", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary_Tissue", title_position = "topleft", grid_height = unit(0.3, "in")),
Primary_Disease = list(title = "Primary Disease", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary Disease", title_position = "topleft", grid_height = unit(0.3, "in")),
Gender = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), grid_height = unit(0.3, "in")),
Source = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Source", title_position = "topleft", grid_height = unit(0.3, "in"))))
chm_plot_cgc <- Heatmap(chm_scores_cgc, name = "CERES Score",
bottom_annotation = chm_annot_list,
bottom_annotation_height = unit(5, "in"),
heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
row_title = "Genes", column_title = "Cancer Cell Lines",
col = colorRamp2(c(min(chm_scores_cgc), 0, max(chm_scores_cgc)), c("purple4", "white", "seagreen4")),
na_col = "black",
row_title_gp = gpar(fontsize = 30, fontface = "bold"),
row_names_gp = gpar(fontsize = 5),
column_title_gp = gpar(fontsize = 30, fontface = "bold"),
column_names_gp = gpar(fontsize = 5),
row_dend_reorder = TRUE,
column_dend_reorder = TRUE,
clustering_distance_rows = "euclidean",
clustering_distance_columns = "euclidean",
clustering_method_rows = "complete",
clustering_method_columns = "complete",
column_dend_height = unit(2, "in"),
row_dend_width = unit(4, "in"),
width = 3)
chm_plot_cgc_cols <- colnames(chm_scores_cgc)[unlist(column_order(chm_plot_cgc))]
chm_plot_cgc_rows <- rownames(chm_scores_cgc)[unlist(row_order(chm_plot_cgc))]
chm_ge_plot_cgc <- Heatmap(chm_ge_cgc, name = "Gene Expression",
col = colorRamp2(c(min(chm_ge_cgc[!is.na(chm_ge_cgc)]), 0, max(chm_ge_cgc[!is.na(chm_ge_cgc)])), c("dodgerblue4", "white", "firebrick4")),
heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
na_col = "black",
cluster_rows = FALSE, cluster_columns = FALSE,
row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
column_title = "Gene Expression",
column_title_gp = gpar(fontsize = 30, fontface = "bold"),
column_order = chm_plot_cgc_cols,
row_order = chm_plot_cgc_rows,
width = 1)
chm_cn_plot_cgc <- Heatmap(chm_cn_cgc, name = "Copy Number",
col = colorRamp2(c(min(chm_cn_cgc[!is.na(chm_cn_cgc)]), 0, max(chm_cn_cgc[!is.na(chm_cn_cgc)])), c("white", "thistle2", "mediumorchid4")),
heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
na_col = "black",
cluster_rows = FALSE, cluster_columns = FALSE,
row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
column_title = "Copy Number",
column_title_gp = gpar(fontsize = 30, fontface = "bold"),
column_order = chm_plot_cgc_cols,
row_order = chm_plot_cgc_rows,
width = 1)
chm_mut_plot_cgc <- Heatmap(chm_mut_cgc, name = "Mutation Status",
na_col = "black",
heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), at = c(0, 1), labels = c("Other", "Mutant"), title_position = "topcenter", grid_height = unit(0.3, "in")),
col = c("cyan3", "darkorchid"),
cluster_rows = FALSE, cluster_columns = FALSE,
row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
column_title = "Mutation Status",
column_title_gp = gpar(fontsize = 30, fontface = "bold"),
column_order = chm_plot_cgc_cols,
row_order = chm_plot_cgc_rows,
width = 1)
chm_all_plot_cgc <- chm_plot_cgc + chm_ge_plot_cgc + chm_cn_plot_cgc + chm_mut_plot_cgc
pdf("./plots_18Q3/crispr_heatmap_euclidean_all_cgc.pdf", width = 50, height = 50, paper = "special")
draw(chm_all_plot_cgc, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()
png("./plots_18Q3/crispr_heatmap_euclidean_all_cgc.png", width = 50, height = 50, units = "in", res = 96)
draw(chm_all_plot_cgc, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()
chm_scores_cgc <- subset(chm_scores, rownames(chm_scores) %in% cgc$Hugo_Symbol)
chm_ge_cgc <- subset(chm_ge, rownames(chm_ge) %in% cgc$Hugo_Symbol)
chm_mut_cgc <- subset(chm_mut, rownames(chm_mut) %in% cgc$Hugo_Symbol)
chm_cn_cgc <- subset(chm_cn, rownames(chm_cn) %in% cgc$Hugo_Symbol)
chm_annot_list <- HeatmapAnnotation(df = chm_annot, annotation_legend_param = list(
Cell_Line_SSMD = list(title = "Cell Line SSMD", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
Cas9_Activity = list(title = "Cas9 Activity", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
Culture_Type = list(title = "Culture Type", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Culture Type", title_position = "topleft", grid_height = unit(0.3, "in")),
Primary_Tissue = list(title = "Primary Tissue", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary_Tissue", title_position = "topleft", grid_height = unit(0.3, "in")),
Primary_Disease = list(title = "Primary Disease", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary Disease", title_position = "topleft", grid_height = unit(0.3, "in")),
Gender = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), grid_height = unit(0.3, "in")),
Source = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Source", title_position = "topleft", grid_height = unit(0.3, "in"))))
chm_plot_cgc <- Heatmap(chm_scores_cgc, name = "CERES Score",
bottom_annotation = chm_annot_list,
bottom_annotation_height = unit(5, "in"),
heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
row_title = "Genes", column_title = "Cancer Cell Lines",
col = colorRamp2(c(min(chm_scores_cgc), 0, max(chm_scores_cgc)), c("purple4", "white", "seagreen4")),
na_col = "black",
row_title_gp = gpar(fontsize = 30, fontface = "bold"),
row_names_gp = gpar(fontsize = 5),
column_title_gp = gpar(fontsize = 30, fontface = "bold"),
column_names_gp = gpar(fontsize = 5),
row_dend_reorder = TRUE,
column_dend_reorder = TRUE,
clustering_distance_rows = "pearson",
clustering_distance_columns = "pearson",
clustering_method_rows = "complete",
clustering_method_columns = "complete",
column_dend_height = unit(2, "in"),
row_dend_width = unit(4, "in"),
width = 3)
chm_plot_cgc_cols <- colnames(chm_scores_cgc)[unlist(column_order(chm_plot_cgc))]
chm_plot_cgc_rows <- rownames(chm_scores_cgc)[unlist(row_order(chm_plot_cgc))]
chm_ge_plot_cgc <- Heatmap(chm_ge_cgc, name = "Gene Expression",
col = colorRamp2(c(min(chm_ge_cgc[!is.na(chm_ge_cgc)]), 0, max(chm_ge_cgc[!is.na(chm_ge_cgc)])), c("dodgerblue4", "white", "firebrick4")),
heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
na_col = "black",
cluster_rows = FALSE, cluster_columns = FALSE,
row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
column_title = "Gene Expression",
column_title_gp = gpar(fontsize = 30, fontface = "bold"),
column_order = chm_plot_cgc_cols,
row_order = chm_plot_cgc_rows,
width = 1)
chm_cn_plot_cgc <- Heatmap(chm_cn_cgc, name = "Copy Number",
col = colorRamp2(c(min(chm_cn_cgc[!is.na(chm_cn_cgc)]), 0, max(chm_cn_cgc[!is.na(chm_cn_cgc)])), c("white", "thistle2", "mediumorchid4")),
heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
na_col = "black",
cluster_rows = FALSE, cluster_columns = FALSE,
row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
column_title = "Copy Number",
column_title_gp = gpar(fontsize = 30, fontface = "bold"),
column_order = chm_plot_cgc_cols,
row_order = chm_plot_cgc_rows,
width = 1)
chm_mut_plot_cgc <- Heatmap(chm_mut_cgc, name = "Mutation Status",
na_col = "black",
heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), at = c(0, 1), labels = c("Other", "Mutant"), title_position = "topcenter", grid_height = unit(0.3, "in")),
col = c("cyan3", "darkorchid"),
cluster_rows = FALSE, cluster_columns = FALSE,
row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
column_title = "Mutation Status",
column_title_gp = gpar(fontsize = 30, fontface = "bold"),
column_order = chm_plot_cgc_cols,
row_order = chm_plot_cgc_rows,
width = 1)
chm_all_plot_cgc <- chm_plot_cgc + chm_ge_plot_cgc + chm_cn_plot_cgc + chm_mut_plot_cgc
pdf("./plots_18Q3/crispr_heatmap_pearson_all_cgc.pdf", width = 50, height = 50, paper = "special")
draw(chm_all_plot_cgc, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()
Plot code:
crispr_lvlA_genes <- unique(crispr_data_cgc$Hugo_Symbol)
crispr_all_groups <- lapply(crispr_all_genes, makeCRISPRgrob)
crispr_all_groups_paths <- paste0(crispr_all_genes, "_crispr_grouped.png")
pwalk(list(crispr_all_groups_paths, crispr_all_groups), ggsave, path = "./plots_18Q3/crispr_grouped_plots_cgc", dpi = 300, width = 12, height = 12, units = "in")
Data management:
crispr_all_bygene <- paste0(list.files("./plots_18Q3/crispr_grouped_plots_cgc", full.names = TRUE))
names(crispr_all_bygene) <- str_replace_all(crispr_all_bygene, c("_crispr_grouped.png" = "", "./plots_18Q3/crispr_grouped_plots_cgc/" = ""))
crispr_bygene_order <- c(intersect(crispr_signif$Hugo_Symbol, names(crispr_all_bygene)), setdiff(names(crispr_all_bygene), crispr_signif$Hugo_Symbol))
crispr_all_bygene <- crispr_all_bygene[match(crispr_bygene_order, names(crispr_all_bygene))]
bsselect(crispr_all_bygene, type = "img", selected = "KRAS", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)
Plot code:
crispr_data_cgc <- filter(crispr_data, Hugo_Symbol %in% cgc$Hugo_Symbol)
crispr_all_genes <- unique(crispr_data_cgc$Hugo_Symbol)
crispr_all_lins <- lapply(crispr_all_genes, makeCRISPRlinplot)
crispr_all_lins_paths <- paste0(crispr_all_genes, "_crispr_lineage.png")
pwalk(list(crispr_all_lins_paths, crispr_all_lins), ggsave, path = "./plots_18Q3/crispr_lineage_plots_cgc", dpi = 300, width = 12, height = 12, units = "in")
Data management:
crispr_all_bygene <- paste0(list.files("./plots_18Q3/crispr_lineage_plots_cgc", full.names = TRUE))
names(crispr_all_bygene) <- str_replace_all(crispr_all_bygene, c("_crispr_lineage.png" = "", "./plots_18Q3/crispr_lineage_plots_cgc/" = ""))
crispr_bygene_order <- c(intersect(crispr_signif$Hugo_Symbol, names(crispr_all_bygene)), setdiff(names(crispr_all_bygene), crispr_signif$Hugo_Symbol))
crispr_all_bygene <- crispr_all_bygene[match(crispr_bygene_order, names(crispr_all_bygene))]
bsselect(crispr_all_bygene, type = "img", selected = "KRAS", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)
tissue_summ <- crispr_meta %>% group_by(primary_tissue) %>% tally()
disease_summ <- ccl_info %>% group_by(Primary.Disease) %>% tally()
ggplot(data = tissue_summ) +
aes(x = 0, y = n, fill = primary_tissue, label = primary_tissue) +
geom_histogram(color = "black", stat = "identity") +
geom_text(position = position_stack(vjust = 0.5)) +
scale_y_continuous(breaks = seq(0, 500, by = 25), labels = seq(0, 500, by = 25)) +
coord_cartesian(ylim = c(0, 500)) +
theme(legend.position = "none", axis.text.x = element_blank(), axis.ticks.x = element_blank(), axis.title.x = element_blank()) +
labs(y = "Count")
Distribution of scores across cell lines and primary tissues. Each data point represents a single cell line.
ceres_summ <- crispr_data %>% group_by(primary_tissue) %>% summarize(Max = max(Score),
Min = min(Score))
score_summ_plot <- ggplot(data = crispr_data, aes(x = primary_tissue, color = primary_tissue)) +
geom_boxplot(mapping = aes(y = Score), outlier.shape = NA) +
geom_point(data = ceres_summ, mapping = aes(x = primary_tissue, y = Min)) +
geom_point(data = ceres_summ, mapping = aes(x = primary_tissue, y = Max)) +
scale_y_continuous(breaks = seq(-4, 6, by = 1), labels = seq(-4, 6, by = 1)) +
theme(axis.text.x = element_text(angle = 30, hjust = 1), legend.position = "none") +
labs(x = "Primary Tissue", y = "CERES Score")
score_summ_plot
# ggsave(filename = "./plots_18Q3/crispr/ceres_score_summ_plot.pdf", plot = score_summ_plot, width = 12, height = 4, device = "pdf")
maf_df_filt <- filter(maf_df, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))
# maf_summ_filt <- maf_df_filt %>% group_by(Mutation_Status) %>% tally()
# maf_summ_filt$Percent <- format(round(maf_summ_filt$n / sum(maf_summ_filt$n) * 100, 4), nsmall = 2)
# maf_summ_filt$Percent <- as.numeric(as.character(maf_summ_filt$Percent))
Distribution of mutations across cell lines and primary tissues. Each data point represents a single cell line.
maf_ccl_annot <- merge(maf_df %>% group_by(Broad_ID) %>% tally(), crispr_meta, by = "Broad_ID", all.y = TRUE)
maf_ccl_annot_plot <- ggplot(data = maf_ccl_annot, aes(x = primary_tissue, y = n, color = primary_tissue)) +
geom_boxplot(outlier.shape = NA, fill = NA) +
geom_jitter(alpha = 0.7, size = 1, position = position_jitter(w = 0.25)) +
scale_y_continuous(breaks = seq(0, 9000, by = 1000), labels = seq(0, 9000, by = 1000)) +
theme(axis.ticks.x = element_blank(), axis.title.x = element_blank(), axis.text.x = element_blank(), legend.position = "none") +
labs(x = "Primary Tissue", y = "Number of Mutations")
maf_ccl_annot_plot
# ggsave(filename = "./plots_18Q3/crispr/maf_ccl_annot_plot.pdf", plot = maf_ccl_annot_plot, width = 12, height = 4, device = "pdf")
# ggsave(filename = "./plots_18Q3/crispr/score_mut_summ.pdf", plot = grid.draw(rbind(ggplotGrob(maf_ccl_annot_plot), ggplotGrob(score_summ_plot), size = "first")), width = 12, height = 8, device = "pdf")
maf_gene_annot <- maf_df_filt %>% group_by(Hugo_Symbol) %>% tally()
ggplot(data = maf_gene_annot, aes(x = n)) +
geom_histogram(breaks = seq(0, 600, by = 20), fill = "darkslategray3", color = "black", alpha = 0.7) +
coord_cartesian(ylim = c(0, 13000)) +
scale_y_continuous(breaks = seq(0, 13500, by = 500), labels = formatC(seq(0, 13500, by = 500), format = "d")) +
scale_x_continuous(breaks = seq(0, 600, by = 20), labels = seq(0, 600, by = 20)) +
theme(axis.text.x = element_text(angle = 45, hjust = 1)) +
stat_bin(breaks = seq(0, 600, by = 20), geom = "text", colour = "black", size = 2.5, aes(label = ..count..), vjust = -0.2, angle = 45, hjust = -0.1) +
labs(x = "Number of Mutations", y = "Frequency", title = paste0("Distribution of mutational load for ", length(unique(maf_gene_annot$Hugo_Symbol)), " genes in the CCLE MAF file across all ", length(unique(crispr_ccl$Broad_ID)), " cell lines in the CRISPR screen"))
drop_prob_100 <- ggplot(data = crispr_data, aes(x = Dep_Prob)) +
geom_histogram(breaks = seq(0, 1, by = 0.05), fill = "darkslategray3", color = "black", alpha = 0.7) +
scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
scale_y_continuous(breaks = seq(0, 5500000, by = 500000), labels = formatC(seq(0, 5500000, by = 500000), format = "d")) +
stat_bin(breaks = seq(0, 1, by = 0.05), geom = "text", colour = "black", size = 3.5, aes(label = ..count..), vjust = -1) +
labs(title = "Distribution of all dependency probabilities", x = "Probability of Real Dependency", y = "Frequency")
dep_prob_5 <- ggplot(data = filter(crispr_data, Dep_Prob >= 0.95), aes(x = Dep_Prob)) +
geom_histogram(mapping = aes(fill = primary_tissue), breaks = seq(0.95, 1, by = 0.005), color = "black") +
scale_y_continuous(breaks = seq(0, 60000, by = 10000), labels = formatC(seq(0, 60000, by = 10000), format = "d")) +
theme(legend.position = "bottom") +
guides(fill = guide_legend(nrow = 4, byrow = FALSE)) +
stat_bin(breaks = seq(0.95, 1, by = 0.005), geom = "text", color = "black", size = 3.5, aes(label = ..count..), vjust = -1) +
labs(title = "Distribution of all dependency probabilities > 0.95", x = "Probability of Real Dependency", y = "Frequency", fill = "Primary Tissue")
sig_genes <- c("KRAS", "TP53", "NRAS", "BRAF", "PIK3CA", "PTEN", "CTNNB1")
crispr_sig_genes <- filter(crispr_data, Hugo_Symbol %in% sig_genes)
crispr_sig_genes$Hugo_Symbol <- factor(crispr_sig_genes$Hugo_Symbol, levels = c("KRAS", "TP53", "NRAS", "BRAF", "PIK3CA", "PTEN", "CTNNB1"))
crispr_color <- as.character(crispr_sig_genes$Color)
names(crispr_color) <- crispr_sig_genes$Mutation_Status
# Mutation status
plot_mut <- ggplot(data = crispr_sig_genes, aes(x = Mutation_Status, y = Score, color = Mutation_Status)) +
geom_boxplot(outlier.shape = NA) +
geom_jitter(alpha = 0.3, size = 0.7, position = position_jitter(w = 0.05)) +
facet_wrap(~ Hugo_Symbol, nrow = 7, scales = "free_y") +
scale_color_manual(values = crispr_color) +
geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
theme_light() +
theme(legend.position = "none") +
labs(x = "Mutation Status", y = "CERES Score",
title = "Mutation Status")
# plot_mut
# Copy number
plot_cn <- ggplot(data = crispr_sig_genes, aes(x = Copy_Number, y = Score, color = Mutation_Status)) +
geom_point(size = 0.5, alpha = 0.5) +
geom_smooth(method = "lm", size = 0.5) +
scale_color_manual(values = crispr_color) +
facet_wrap(~ Hugo_Symbol, nrow = 7, scales = "free") +
stat_cor(method = "pearson", show.legend = FALSE, label.x.npc = "right", label.y.npc = "top") +
theme_light() +
theme(legend.position = "none", axis.title.y = element_blank()) +
labs(y = "CERES Score", color = "Mutation Status",
x = "Theoretical Copy number", title = "Copy Number")
# plot_cn
# Gene expression
plot_ge <- ggplot(data = crispr_sig_genes, aes(x = RPKM_log2, y = Score, color = Mutation_Status)) +
geom_point(size = 0.5, alpha = 0.5) +
geom_smooth(method = "lm", size = 0.5) +
facet_wrap(~ Hugo_Symbol, nrow = 7, scales = "free_y") +
scale_color_manual(values = crispr_color) +
stat_cor(method = "pearson", show.legend = FALSE, label.x.npc = "left", label.y.npc = "top") +
theme_light() +
theme(legend.position = "none", axis.title.y = element_blank()) +
labs(y = "CERES Score", color = "Mutation Status",
x = "Gene Expression [log2(RPKM)]",
title = "Gene Expression")
# plot_ge
# ggsave(filename = "./plots_18Q3/crispr/omics_sig_genes.pdf", plot = grid.draw(cbind(ggplotGrob(plot_mut), ggplotGrob(plot_ge), ggplotGrob(plot_cn), size = "last")), width = 15, height = 18, device = "pdf")
DepMap cell line metadata:
# From figshare
shrna_meta <- read.delim("./data_munging/sample_info_18Q3_shrna.csv", sep = ",", header = TRUE, na.strings = c("", NA))
colnames(shrna_meta)[1] <- "CCLE_Name"
The Achilles shRNA DEMETER score data was pulled from the CTD2 Data Portal (Tsherniak et al 2017).
shrna <- read.table("./data_munging/D2_combined_gene_dep_scores.csv.gz", sep = ",", header = TRUE, check.names = FALSE)
colnames(shrna)[1] <- "Hugo_Symbol"
# Remove Entrez gene IDs from gene names
shrna$Hugo_Symbol <- gsub(" .*", "", shrna$Hugo_Symbol)
# Melt shRNA dataset for merging
shrna_melt <- melt(shrna , id.vars = "Hugo_Symbol", measure.vars = colnames(shrna)[2:ncol(shrna)], variable.name = "CCLE_Name", value.name = "Score")
shrna_melt <- drop_na(shrna_melt)
Merge annotation data:
# Merge cell line metadata
shrna_melt <- merge(shrna_melt, ccl_info, by = "CCLE_Name", all.x = TRUE)
shrna_melt <- merge(shrna_melt, shrna_meta, by = "CCLE_Name", all.x = TRUE)
# Merge mutation annotations
shrna_muts <- merge(shrna_melt, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
shrna_muts <- shrna_muts %>% mutate(Mutation_Status = if_else(is.na(Mutation_Status), "Other", Mutation_Status))
shrna_muts$Hugo_Symbol <- factor(shrna_muts$Hugo_Symbol)
# Summarize number of mutant and Other cell lines
shrna_muts_summ <- shrna_muts %>% group_by(Hugo_Symbol) %>%
summarize(N_Other = sum(Mutation_Status == "Other"),
N_Mutant = sum(Mutation_Status == "Mutant"))
# Merge test results back into full dataset, which restores information lost in the summarization
shrna_data <- merge(shrna_muts_summ, shrna_muts, by = "Hugo_Symbol")
# Add Color column
shrna_data$Color <- ifelse(shrna_data$Mutation_Status == "Other", "cyan3", "darkorchid")
shrna_data$Color <- factor(shrna_data$Color)
# Cell line lineages
shrna_data <- merge(shrna_data, ccl_converter, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
levels(shrna_data$lineage_name) <- sort(levels(shrna_data$lineage_name), decreasing = TRUE)
# Copy number
shrna_data <- merge(shrna_data, cn_melt, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)
# Gene expression (RPKM)
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(shrna_data$Hugo_Symbol))
shrna_data <- merge(shrna_data, ge_filt, by = c("Hugo_Symbol", "Broad_ID", "CCLE_Name"), all.x = TRUE)
saveRDS(shrna_data, "./../crispr_lineages_giant_files/shrna_data_18Q3.rds", compress = "xz")
shrna_data <- readRDS("./../crispr_lineages_giant_files/shrna_data_18Q3.rds")
shrna_ccl <- data.frame("Broad_ID" = shrna_data$Broad_ID)
shrna_signif <- compare_means(Score ~ Mutation_Status, group.by = c("Hugo_Symbol"), data = shrna_data, method = "wilcox.test", p.adjust.method = "BH")
shrna_signif <- adj_signif(shrna_signif)
shrna_signif <- shrna_signif[order(shrna_signif$p),]
saveRDS(shrna_signif, "./data_munging/rds/shrna_signif.rds")
shrna_signif <- readRDS("./data_munging/rds/shrna_signif.rds")
knitr::kable(filter(shrna_signif, p < 0.01)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "shRNA Screen: Wilcoxon Test Results Comparing Mutant and Other Cell Lines, p < 0.1 (Benjamini-Hochberg-corrected p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
shrna_signif_lineage <- compare_means(Score ~ Mutation_Status, group.by = c("Hugo_Symbol", "lineage_name"), data = shrna_data, method = "wilcox.test", p.adjust.method = "BH")
shrna_signif_lineage <- adj_signif(shrna_signif_lineage)
shrna_signif_lineage <- mutate(shrna_signif_lineage, lineage_name = reorder(lineage_name, p.adj, mean))
saveRDS(shrna_signif_lineage, "./../crispr_lineages_giant_files/shrna_signif_lineage.rds")
shrna_signif_lineage <- readRDS("./../crispr_lineages_giant_files/shrna_signif_lineage.rds")
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print(sessionInfo())
## R version 3.5.0 (2018-04-23)
## Platform: x86_64-apple-darwin15.6.0 (64-bit)
## Running under: macOS 10.14
##
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRlapack.dylib
##
## locale:
## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
##
## attached base packages:
## [1] parallel grid stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] bindrcpp_0.2.2 forcats_0.3.0 stringr_1.3.1
## [4] dplyr_0.7.6 purrr_0.2.5 readr_1.1.1
## [7] tidyr_0.8.1 tibble_1.4.2 tidyverse_1.2.1
## [10] rowr_1.1.3 reshape2_1.4.3 plyr_1.8.4
## [13] NMF_0.21.0 Biobase_2.40.0 BiocGenerics_0.26.0
## [16] cluster_2.0.7-1 rngtools_1.3.1 pkgmaker_0.27
## [19] registry_0.5 matrixStats_0.54.0 kableExtra_0.9.0
## [22] jsonlite_1.5.9000 gridExtra_2.3 glmnet_2.0-16
## [25] foreach_1.4.4 Matrix_1.2-14 ggord_1.1.2
## [28] ggfortify_0.4.5 ggsignif_0.4.0 ggpubr_0.1.7.999
## [31] magrittr_1.5 devtools_1.13.6 data.table_1.11.4
## [34] ComplexHeatmap_1.18.1 circlize_0.4.4 CePa_0.6
## [37] caret_6.0-80 ggplot2_3.0.0 lattice_0.20-35
## [40] bsselectR_0.1.0 broom_0.5.0
##
## loaded via a namespace (and not attached):
## [1] colorspace_1.3-2 rjson_0.2.20 class_7.3-14
## [4] rprojroot_1.3-2 pls_2.6-0 GlobalOptions_0.1.0
## [7] rstudioapi_0.7 DRR_0.0.3 prodlim_2018.04.18
## [10] lubridate_1.7.4 xml2_1.2.0 codetools_0.2-15
## [13] splines_3.5.0 doParallel_1.0.11 robustbase_0.93-1.1
## [16] knitr_1.20 RcppRoll_0.3.0 gridBase_0.4-7
## [19] ddalpha_1.3.4 kernlab_0.9-26 sfsmisc_1.1-2
## [22] graph_1.58.0 compiler_3.5.0 httr_1.3.1
## [25] backports_1.1.2 assertthat_0.2.0 lazyeval_0.2.1
## [28] cli_1.0.0 htmltools_0.3.6 tools_3.5.0
## [31] igraph_1.2.1 gtable_0.2.0 glue_1.3.0
## [34] Rcpp_0.12.18 cellranger_1.1.0 nlme_3.1-137
## [37] iterators_1.0.10 timeDate_3043.102 gower_0.1.2
## [40] rvest_0.3.2 DEoptimR_1.0-8 MASS_7.3-50
## [43] scales_1.0.0 ipred_0.9-6 hms_0.4.2
## [46] RColorBrewer_1.1-2 yaml_2.1.19 memoise_1.1.0
## [49] rpart_4.1-13 stringi_1.2.4 highr_0.7
## [52] bibtex_0.4.2 lava_1.6.2 geometry_0.3-6
## [55] shape_1.4.4 rlang_0.2.1 pkgconfig_2.0.1
## [58] evaluate_0.11 bindr_0.1.1 labeling_0.3
## [61] recipes_0.1.3 htmlwidgets_1.2 CVST_0.2-2
## [64] tidyselect_0.2.4 R6_2.2.2 dimRed_0.1.0
## [67] haven_1.1.2 pillar_1.3.0 withr_2.1.2
## [70] survival_2.42-6 abind_1.4-5 nnet_7.3-12
## [73] modelr_0.1.2 crayon_1.3.4 rmarkdown_1.10
## [76] GetoptLong_0.1.7 readxl_1.1.0 Rgraphviz_2.24.0
## [79] ModelMetrics_1.1.0 digest_0.6.15 xtable_1.8-2
## [82] stats4_3.5.0 munsell_0.5.0 viridisLite_0.3.0
## [85] magic_1.5-8