Analysis of the Broad’s Avana CRISPR (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017) and the Broad and Dana-Farber Cancer Institite’s Achilles shRNA (MacFarland et al. 2018, Data Science 2018).

The Avana screen produced results using CERES (Meyers et al. 2017) (GitHub), which generates gene dependency scores from sgRNA depletion scores from gene essentiality screens and eliminates bias arising from the effect of copy number variation on Cas9 DNA cleavage. The lower the CERES score, the higher the likelihood that the gene is essential in the associated cell line. Scores are scaled per cell line such that a score of 0 is the median effect of nonessential genes and -1 is the median effect of common core essential genes.

In a previous version of the shRNA screen, DEMETER (GitHub) was used to compute a dependency score for each gene by using the depletion values from each shRNA to infer the effect of target knockdown (on-target) and of expressing a given miRNA seed (off-target) in each cell line. More negative values indicate increased dependency, while more positive values indicate lower dependency. Zero represents the avergae dependency across all cell lines.

In the new data release, DEMETER2 (GitHub repository), developed by McFarland et al. (2018) was used to analyze the Achilles screen. DEMETER2 expands on DEMETER by including parameters for cell-line-specific screen effects and noisy data, correcting for global differences in shRNA levels across cell lines, pooling data acorss cell lines via hierarchical modeling, and using Bayesian inference to compute uncertainty estimates. Now, a score of zero represents no dependency.

All annotation files (copy number, mutation status, and gene expression) (Consortium and Consortium 2015, Barretina et al. 2012) were downloaded from the DepMap Data Portal.

1 Set up

Load libraries.

library(broom)
library(bsselectR)
library(caret)
library(CePa)
library(circlize)
library(ComplexHeatmap)
library(data.table)
library(devtools)
library(ggpubr)
library(ggsignif)
library(ggfortify)
library(ggord)
library(glmnet)
library(gridExtra)
library(jsonlite)
library(jsonlite)
library(kableExtra)
library(magrittr)
library(matrixStats)
library(NMF)
library(parallel)
library(plyr)
library(reshape2)
library(rowr)
library(tidyverse)

2 Functions

2.1 Significance thresholding

adj_signif <- function(df) {
  # Takes df from compare_means and creates a signif code column for adjusted p-vals
  df$p.signif <- ifelse(df$p.signif == "ns", NA, df$p.signif)
  df$p.signif.adj <- ifelse(df$p.adj <= 0.0001, "****",
                     ifelse(df$p.adj <= 0.001, "***",
                     ifelse(df$p.adj <= 0.01, "**",
                     ifelse(df$p.adj <= 0.05, "*", NA))))
  df$p.short <- formatC(df$p, format = "g", digits =  2)
  df$p.adj.short <- formatC(df$p.adj, format = "g", digits =  2)
  
  return(df)
}

2.2 Make CRISPR grouped plots

makeCRISPRgrob <- function(g, filt_method) {
  if(filt_method == "lvlA") {
    gene <- filter(crispr_data_lvlA, Hugo_Symbol == g)
    sig <- filter(crispr_signif_lvlA, Hugo_Symbol == g)
  }
  if(filt_method == "all") {
    gene <- filter(crispr_data_ptmuts, Hugo_Symbol == g)
    sig <- filter(crispr_signif_nonsilent, Hugo_Symbol == g)
  }
  
  # Mutation status
  crispr_color <- as.character(gene$Color_Nonsilent)
  names(crispr_color) <- gene$Mutation_Status_Nonsilent

  plot_mut <- ggplot(data = gene, aes(x = Mutation_Status_Nonsilent, y = Score, color = Mutation_Status_Nonsilent)) +
    geom_boxplot(outlier.shape = NA) +
    geom_jitter(alpha = 0.3, size = 0.7, position = position_jitter(w = 0.05)) +
    scale_color_manual(values = crispr_color) +
    geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
    theme_light() +
    theme(legend.position = "none") +
    labs(x = paste0(g, " Mutation Status"), y = "CERES Score",
         title = "Mutation Status",
         subtitle = paste0("Wilcoxon test:\n- BH-corrected p-value: ", sig$p.adj.short, "\n- Uncorrected p-value: ", sig$p.short))
  
  # Copy number
  lo_cn <- range(gene$Copy_Number[!is.na(gene$Copy_Number)])[1]
  hi_cn <- range(gene$Copy_Number[!is.na(gene$Copy_Number)])[2]
  mid_cn <- (hi_cn - lo_cn) / 2
  plot_cn <- ggplot(data = gene, aes(x = Copy_Number, y = Score, color = Mutation_Status_Nonsilent)) +
    geom_point(size = 0.5, alpha = 0.5) +
    geom_smooth(method = "lm", size = 0.5) +
    geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
    scale_color_manual(values = crispr_color) +
    stat_cor(method = "pearson", show.legend = FALSE, label.x = c((lo_cn + mid_cn) / 2, (hi_cn - mid_cn) / 2 + mid_cn), label.y = max(gene$Score)) +
    theme(legend.position = "none") +
    labs(y = "CERES Score", color = "Mutation Status",
         x = paste0(g, " Theoretical Copy number"), title = "Copy Number",
         subtitle = "r: Pearson correlation coeffcient")
  
  # Gene expression
  lo_ge <- range(gene$RPKM_log2[!is.na(gene$RPKM_log2)])[1]
  hi_ge <- range(gene$RPKM_log2[!is.na(gene$RPKM_log2)])[2]
  mid_ge <- (hi_ge - lo_ge) / 2
  plot_ge <- ggplot(data = gene, aes(x = RPKM_log2, y = Score, color = Mutation_Status_Nonsilent)) +
    geom_point(size = 0.5, alpha = 0.5) +
    geom_smooth(method = "lm", size = 0.5) +
    geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
    scale_color_manual(values = crispr_color) +
    stat_cor(method = "pearson", show.legend = FALSE, label.x = c((lo_ge + mid_ge) / 2, (hi_ge - mid_ge) / 2 + mid_ge), label.y = max(gene$Score)) +
    theme(legend.position = "none") +
    labs(y = "CERES Score", color = "Mutation Status",
         x = paste0(g, " Gene Expression [log2(RPKM)]"),
         title = "Gene Expression",
         subtitle = "r: Pearson correlation coeffcient")
  
  # Cell line lineage
  plot_tissue <- ggplot(data = gene, aes(x = primary_tissue, y = Score, color = Mutation_Status_Nonsilent)) +
    geom_point(alpha = 0.5) +
    scale_color_manual(values = crispr_color) +
    geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
    scale_y_continuous(sec.axis = sec_axis(~ .)) +
    coord_flip() +
    theme(legend.position = "none") +
    labs(y = "CERES Score", x = "Primary Tissue",
         color = "Mutation Status", title = g)
  
  # Arrange plots
  plot <- ggarrange(ggarrange(plot_tissue, nrow = 1, labels = c("A")),
                    ggarrange(plot_mut, plot_cn, plot_ge, nrow = 3,
                              labels = c("B", "C", "D"), heights = c(2, 3, 3)),
                    font.label = list(size = 30, face = "bold"),
                    nrow = 1, ncol = 2, widths = c(3, 2))
  return(plot)
}

2.3 Make sorted lineage plots

makeCRISPRlinplot <- function(g) {
  sig <- filter(crispr_signif_lineage, Hugo_Symbol == g)
  if(nrow(sig) == 0) {
    return(NULL)
  }
  else {
    gene <- filter(crispr_data, Hugo_Symbol == g)
    gene <- merge(gene, sig, by = c("Hugo_Symbol", "group_general_lineage_name"))
    gene <- mutate(gene, group_general_lineage_name = reorder(group_general_lineage_name, p, mean))
    crispr_color <- as.character(gene$Color)
    names(crispr_color) <- gene$Mutation_Status
    score_range <- abs(range(gene$Score)[2] - range(gene$Score)[1])
    round_accuracy <- ifelse(score_range <= 2, 0.25,
                             ifelse(score_range <= 3, 0.5, 1.0))
    
    plot <- ggplot(data = gene, aes(x = group_general_lineage_name, y = Score)) +
      geom_point(alpha = 0.5, mapping = aes(color = Mutation_Status)) +
      scale_color_manual(values = crispr_color) +
      coord_cartesian(y = c(min(gene$Score), round_any(x = max(gene$Score), accuracy = round_accuracy, f = ceiling))) +
      geom_signif(data = gene, mapping = aes(xmin = group_general_lineage_name, xmax = group_general_lineage_name, annotations = paste(p.short, "\n", p.adj.short), y_position = max(gene$Score)), manual = TRUE, tip_length   = 0, size = 0, textsize = 3) +
      theme(legend.position = "top", axis.text.x = element_text(angle = 70, hjust = 1, size = 10)) +
      labs(y = "CERES Score",
           x = "Lineage",
           color = "Mutation Status",
           title = paste0(g, ": CERES score by cell line lineage"),
           subtitle = "Lineages sorted by increasing p-value; labels indicate unadjusted p-value / BH-corrected p-value.\nMutant lines harbor deleterious mutations.")
    return(plot)
  }
}

2.4 Wilcoxon tests by drug

WilcoxonByDrug <- function(drug, dataset, data_name) {
  use_data <- filter(dataset, Drug == drug)
  sig <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Hugo_Symbol", data = use_data, method = "wilcox.test", p.adjust.method = "BH")
  sig <- adj_signif(sig)
  sig <- sig[order(sig$p),]
  sig$Drug <- drug
  sig$Dataset <- data_name
  return(sig)
}

2.5 Make drug screen boxplots

makeDrugBoxplots <- function(drug, dataset) {
  if(dataset == "CCLE" | dataset == "ccle") {
    use_data <- filter(ccle_ptmuts_lvlA_filt, Drug == drug)
    use_color <- as.character(use_data$Color_Nonsilent)
    names(use_color) <- use_data$Mutation_Status_Nonsilent
    sig <- ccle_signif_lvlA_ByDrug[[drug]]
    # sig <- filter(ccle_signif_lvlA, Drug == drug)
    label_text <- data.frame(p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
    label_text <- filter(label_text, Hugo_Symbol %in% genes_lvlA_filt)
    label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = genes_lvlA_filt)
  }
  else if(dataset == "CTRP" | dataset == "ctrp") {
    use_data <- filter(ctrp_ptmuts_lvlA_filt, Drug == drug)
    use_color <- as.character(use_data$Color_Nonsilent)
    names(use_color) <- use_data$Mutation_Status_Nonsilent
    sig <- ctrp_signif_lvlA_ByDrug[[drug]]
    # sig <- filter(ctrp_signif_lvlA, Drug == drug)
    label_text <- data.frame(p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
    label_text <- filter(label_text, Hugo_Symbol %in% genes_lvlA_filt)
    label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = genes_lvlA_filt)
  }
  else if(dataset == "GDSC" | dataset == "gdsc") {
    use_data <- filter(gdsc_ptmuts_lvlA_filt, Drug == drug)
    use_color <- as.character(use_data$Color_Nonsilent)
    names(use_color) <- use_data$Mutation_Status_Nonsilent
    sig <- gdsc_signif_lvlA_ByDrug[[drug]]
    # sig <- filter(gdsc_signif_lvlA, Drug == drug)
    label_text <- data.frame(p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
    label_text <- filter(label_text, Hugo_Symbol %in% genes_lvlA_filt)
    label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = genes_lvlA_filt)
  }
  else { return("Error: Invalid dataset.") }
    
  plot <- ggplot(data = use_data, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
    facet_wrap(~ Hugo_Symbol, drop = FALSE, ncol = length(genes_lvlA_filt)) +
    geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
    geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85)) +
    scale_fill_manual(values = use_color) +
    guides(color = FALSE) +
    geom_text(data = label_text, mapping = aes(x = 1.5, y = max(use_data$AUC), label = p.signif.adj)) +
    theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
    labs(fill = "Mutation Status", y = "AUC", x = "Mutation Status", title = paste0(dataset, ": ", drug))
  return(plot)
}

3 Data management

3.1 D. Charytonowicz cell line converter

This comprehensive cancer cell line information curated by Daniel Charytonowicz.

ccl_converter <- read.delim("./data_munging/cell_line_database_v1_20180911.tsv", row.names = 1, sep = "\t", header = TRUE)

3.2 CGC gene list

Select genes from the Cancer Gene Census (CGC). The list was pulled from the International Cancer Genome Consortium (ICGC) data portal (Advaced Search > Genes > Curated Gene Set > Cancer Gene Census).

cgc <- data_frame("Hugo_Symbol" = read.delim("./data_munging/gene-ids-for-set-Cancer Gene Census.tsv", header = FALSE, sep = "\t")[, 2])

3.3 DepMap cell line metadata

ccl_info <- read.delim("./data_munging/DepMap-2018q3-celllines.csv", sep = ",", header = TRUE, na.strings = c("", NA))
ccl_info$Primary.Disease <- gsub("\\\\", "", ccl_info$Primary.Disease)
ccl_info$Primary.Disease <- gsub("Ewings", "Ewing's", ccl_info$Primary.Disease)

# From figshare
crispr_meta <- read.delim("./data_munging/sample_info_18Q3_crispr.csv", sep = ",", header = TRUE, na.strings = c("", NA))
colnames(crispr_meta)[7] <- "CCLE_Name"

3.4 Genomic annotations

3.4.1 CCLE MAF file

For mutation calling, get paired gene name and cell line fields in a data frame. For this analysis, we don’t care about how many mutations there are per gene or what type of mutations there are, so I didn’t save more information. I took unique gene-cell line combinations since we only cared about mutation presence/absence. Add a Mutation_Status column denoting all entries in MAF files as mutations present in the associated cell lines.

maf_raw <- read.delim("./data_munging/CCLE_DepMap_18q3_maf_20180718.txt.gz", header = TRUE, sep = "\t")
# Filter for cell lines in CRISPR screen
maf_raw <- filter(maf_raw, Broad_ID %in% unique(crispr_meta$Broad_ID))
colnames(maf_raw)[colnames(maf_raw) == "Tumor_Sample_Barcode"] <- "CCLE_Name"

# Select columns
maf_df <- subset(maf_raw, select = c("Hugo_Symbol", "CCLE_Name", "Broad_ID", "Variant_Classification", "Reference_Allele", "Tumor_Seq_Allele1"))
maf_df$Reference_Allele_Length <- ifelse(maf_df$Reference_Allele == "-", 0, nchar(as.character(maf_df$Reference_Allele)))
maf_df$Tumor_Seq_Allele1_Length <- nchar(as.character(maf_df$Tumor_Seq_Allele1))

# Add Mutation_Status column
maf_df$Mutation_Status_Nonsilent <- ifelse(maf_df$Variant_Classification == "Silent", "Other", "Mutant")
maf_df <- unique(subset(maf_df, select = c("Hugo_Symbol", "CCLE_Name", "Broad_ID", "Mutation_Status_Nonsilent", "Reference_Allele_Length", "Tumor_Seq_Allele1_Length")))

# Whole MAF summary table
maf_summ <- maf_raw[, c("Variant_Classification", "isDeleterious")] %>% group_by(Variant_Classification, isDeleterious) %>% tally()
maf_summ$Percent <- format(round(maf_summ$n / sum(maf_summ$n) * 100, 4), nsmall = 2)
maf_summ$isDeleterious <- ifelse(maf_summ$isDeleterious == "TRUE", "Yes", "No")

knitr::kable(maf_summ, caption = "Distribution of variant classifications in the MAF file") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive"))
Distribution of variant classifications in the MAF file
Variant_Classification isDeleterious n Percent
3’UTR No 1 0.0003
3’UTR Yes 30 0.0084
5’Flank No 8 0.0022
5’Flank Yes 34 0.0095
5’UTR No 2 0.0006
5’UTR Yes 15 0.0042
De_novo_Start_OutOfFrame Yes 2006 0.5595
Frame_Shift_Del Yes 12441 3.4698
Frame_Shift_Ins Yes 9215 2.5701
IGR No 6 0.0017
IGR Yes 44 0.0123
In_Frame_Del No 1747 0.4872
In_Frame_Ins No 442 0.1233
Intron No 9 0.0025
Intron Yes 187 0.0522
Missense_Mutation No 211359 58.9484
Nonsense_Mutation Yes 12711 3.5451
Nonstop_Mutation Yes 335 0.0934
Silent No 94225 26.2795
Splice_Site Yes 13180 3.6759
Start_Codon_Del Yes 25 0.0070
Start_Codon_Ins Yes 33 0.0092
Start_Codon_SNP No 402 0.1121
Stop_Codon_Del No 1 0.0003
Stop_Codon_Del Yes 52 0.0145
Stop_Codon_Ins Yes 39 0.0109

3.4.2 CCLE copy number file

cn <- read.delim("./data_munging/public_18Q3_gene_cn_v2.csv.gz", sep = ",", check.names = FALSE, header = TRUE)

# Convert log2 ratios (log2(CN/2)) to CN
cn[2:ncol(cn)] <- lapply(cn[2:ncol(cn)], function(x) 2 * (2 ^ x))

# Remove Entrez gene IDs from colnames
colnames(cn) <- gsub(" .*", "", colnames(cn))
colnames(cn)[1] <- "Broad_ID"

# Melt
cn_melt <- melt(data = cn, id.vars = "Broad_ID", measure.vars = colnames(cn[2:ncol(cn)]), variable.name = "Hugo_Symbol", value.name = "Copy_Number")

saveRDS(cn_melt, "./data_munging/rds/cn_melt_18Q3.rds", compress = "xz")
cn_melt <- readRDS("./data_munging/rds/cn_melt_18Q3.rds")

3.4.3 CCLE gene expression file

Gene expression data (Reads Per Kilobase of transcript, per Million mapped reads, RPKM).

ge <- read.delim("./../crispr_lineages_giant_files/CCLE_DepMap_18q3_RNAseq_RPKM_20180718.gct.gz", skip = 2, header = TRUE, sep = "\t", check.names = FALSE)

# Edit columns
ge$Name <- NULL
colnames(ge)[1] <- "Hugo_Symbol"

# Melt
ge_melt <- melt(data = ge, id.vars = "Hugo_Symbol", measure.vars = colnames(ge[2:ncol(ge)]), value.name = "RPKM")
## Split variable column
ge_melt <- with(ge_melt, cbind(Hugo_Symbol, colsplit(variable, pattern = " ", names = c("CCLE_Name", "Broad_ID")), RPKM))
## Remove parentheses around Broad IDs
ge_melt$Broad_ID <- gsub("\\(|\\)", "", ge_melt$Broad_ID)

saveRDS(ge_melt, "./../crispr_lineages_giant_files/ge_melt_18Q3.rds", compress = "xz")
ge_melt <- readRDS("./../crispr_lineages_giant_files/ge_melt_18Q3.rds")

3.5 CRISPR

3.5.1 DepMap dependency probabilities

dep <- read.delim("./data_munging/gene_dependency_18Q3.csv.gz", sep = ",", header  = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(dep) <- gsub(" .*", "", colnames(dep))

3.5.2 Merge CRISPR data and annotations

The latest CRISPR CERES score data (18Q3, August 2018) was pulled from the DepMap Data Portal (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017).

crispr <- read.delim("./data_munging/gene_effect_18Q3.csv.gz", sep = ",", header  = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(crispr) <- gsub(" .*", "", colnames(crispr))

Merge annotation data:

# Melt CRISPR dataset for merging
crispr_melt <- melt(crispr, id.vars = "Broad_ID", measure.vars = colnames(crispr)[2:ncol(crispr)], variable.name = "Hugo_Symbol", value.name = "Score")
# Melt dependency probabilities dataset for merging
dep_melt <- melt(dep, id.vars = "Broad_ID", measure.vars = colnames(dep)[2:ncol(dep)], variable.name = "Hugo_Symbol", value.name = "Dep_Prob")
# Merge dependency probabilities
crispr_melt <- merge(crispr_melt, dep_melt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
# Merge cell line metadata
crispr_melt <- merge(crispr_melt, ccl_info, by = "Broad_ID", all.x = TRUE)
crispr_melt <- merge(crispr_melt, crispr_meta, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
# Merge mutation annotations
crispr_muts <- merge(crispr_melt, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
crispr_muts$Hugo_Symbol <- factor(crispr_muts$Hugo_Symbol)
crispr_muts <- crispr_muts %>% mutate(Mutation_Status_Nonsilent = if_else(is.na(Mutation_Status_Nonsilent), "Other", Mutation_Status_Nonsilent))
# Summarize number of mutant and Other cell lines
crispr_muts_summ <- crispr_muts %>% group_by(Hugo_Symbol) %>%
  summarize(N_Nonsilent_Other = sum(Mutation_Status_Nonsilent == "Other"),
            N_Nonsilent_Mutant = sum(Mutation_Status_Nonsilent == "Mutant"))
# Merge test results back into full dataset, which restores information lost in the summarization
crispr_data <- merge(crispr_muts_summ, crispr_muts, by = "Hugo_Symbol")
# Add Color columns
crispr_data$Color_Nonsilent <- ifelse(crispr_data$Mutation_Status_Nonsilent == "Other", "thistle", "darkorchid")
crispr_data$Color_Nonsilent <- factor(crispr_data$Color_Nonsilent)
# Cell line lineages
crispr_data <- merge(crispr_data, ccl_converter, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
levels(crispr_data$lineage_name) <- sort(levels(crispr_data$lineage_name), decreasing = TRUE)
# Copy number
crispr_data <- merge(crispr_data, cn_melt, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)
# Gene expression (RPKM)
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol) & Broad_ID %in% unique(crispr_data$Broad_ID))
crispr_data <- merge(crispr_data, ge_filt, by = c("Hugo_Symbol", "Broad_ID", "CCLE_Name"), all.x = TRUE)
crispr_data$RPKM_log2 <- log2(crispr_data$RPKM + 0.0001)
saveRDS(crispr_data, "./../crispr_lineages_giant_files/crispr_data_18Q3.rds", compress = "xz")
crispr_data <- readRDS("./../crispr_lineages_giant_files/crispr_data_18Q3.rds")
crispr_ccl <- data.frame("Broad_ID" = crispr_data$Broad_ID)
# write.table(crispr_data, file = "~/Desktop/crispr_data.tsv", quote = FALSE, sep = "\t")

3.6 Drug screens

g2p <- read.delim("./data_munging/g2p_full_level_A_dataset_v2_10_10_2018.tsv", sep = "\t", header = TRUE)
genes_lvlA_df <- data.frame(Hugo_Symbol = unique(g2p$Gene))
genes_lvlA <- unique(g2p$Gene)
# Drug metadata
drug_meta <- read.delim("./data_munging/drug_id_drug_name_table_10_12_2018.tsv", sep = "\t", header = FALSE)
colnames(drug_meta) <- c("CID", "Drug")
drug_meta$Drug <- tolower(drug_meta$Drug)
maf_df_lvlA <- filter(maf_df, Hugo_Symbol %in% genes_lvlA)

# CCLE
ccle <- read.delim("./data_munging/data_drug_auc_ccle_10_12_2018.csv", sep = "\t", header  = TRUE, row.names = 1, check.names = FALSE)
ccle <- merge(drug_meta, ccle, by = "CID")
ccle_melt <- melt(ccle, id.vars = c("CID", "Drug"), measure.vars = colnames(ccle)[3:ncol(ccle)], variable.name = "accession_id", value.name = "AUC")
ccle_grid <- expand.grid("accession_id" = unique(ccle_melt$accession_id), "Hugo_Symbol" = genes_lvlA)
ccle_data <- merge(ccle_grid, ccle_melt, by = "accession_id", all.x = TRUE)
ccle_data <- merge(ccle_data, ccl_converter, by = "accession_id", all.x = TRUE)
ccle_data <- merge(ccle_data, maf_df_lvlA, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ccle_data$Mutation_Status_Nonsilent <- ifelse(is.na(ccle_data$Mutation_Status_Nonsilent), "Other", ccle_data$Mutation_Status_Nonsilent)
ccle_data$Hugo_Symbol <- factor(ccle_data$Hugo_Symbol)
ccle_data$AUC <- as.numeric(ccle_data$AUC)
ccle_data$Color_Nonsilent <- ifelse(ccle_data$Mutation_Status_Nonsilent == "Other", "palegreen3", "springgreen4")
ccle_data$Color_Nonsilent <- factor(ccle_data$Color_Nonsilent)
ccle_data <- filter(ccle_data, !is.na(ccle_data$AUC))
saveRDS(ccle_data, "./data_munging/rds/ccle_data_18Q3.rds", compress = "xz")

# CTRP
ctrp <- read.delim("./data_munging/data_drug_auc_ctrp_10_12_2018.csv", sep = "\t", header  = TRUE, row.names = 1, check.names = FALSE)
ctrp <- merge(drug_meta, ctrp, by = "CID")
ctrp_melt <- melt(ctrp, id.vars = c("CID", "Drug"), measure.vars = colnames(ctrp)[3:ncol(ctrp)], variable.name = "accession_id", value.name = "AUC")
ctrp_grid <- expand.grid("accession_id" = unique(ctrp_melt$accession_id), "Hugo_Symbol" = genes_lvlA)
ctrp_data <- merge(ctrp_grid, ctrp_melt, by = "accession_id", all.x = TRUE)
ctrp_data <- merge(ctrp_data, ccl_converter, by = "accession_id", all.x = TRUE)
ctrp_data <- merge(ctrp_data, maf_df_lvlA, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ctrp_data$Mutation_Status_Nonsilent <- ifelse(is.na(ctrp_data$Mutation_Status_Nonsilent), "Other", ctrp_data$Mutation_Status_Nonsilent)
ctrp_data$Hugo_Symbol <- factor(ctrp_data$Hugo_Symbol)
ctrp_data$AUC <- as.numeric(ctrp_data$AUC)
ctrp_data$Color_Nonsilent <- ifelse(ctrp_data$Mutation_Status_Nonsilent == "Other", "slategray3", "steelblue4")
ctrp_data$Color_Nonsilent <- factor(ctrp_data$Color_Nonsilent)
ctrp_data <- filter(ctrp_data, !is.na(ctrp_data$AUC))
saveRDS(ctrp_data, "./data_munging/rds/ctrp_data_18Q3.rds", compress = "xz")

# GDSC
gdsc <- read.delim("./data_munging/data_drug_auc_gdsc_10_12_2018.csv", sep = "\t", header  = TRUE, row.names = 1, check.names = FALSE)
gdsc <- merge(drug_meta, gdsc, by = "CID")
gdsc_melt <- melt(gdsc, id.vars = c("CID", "Drug"), measure.vars = colnames(gdsc)[3:ncol(gdsc)], variable.name = "accession_id", value.name = "AUC")
gdsc_grid <- expand.grid("accession_id" = unique(gdsc_melt$accession_id), "Hugo_Symbol" = genes_lvlA)
gdsc_data <- merge(gdsc_grid, gdsc_melt, by = "accession_id", all.x = TRUE)
gdsc_data <- merge(gdsc_data, ccl_converter, by = "accession_id", all.x = TRUE)
gdsc_data <- merge(gdsc_data, maf_df_lvlA, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
gdsc_data$Mutation_Status_Nonsilent <- ifelse(is.na(gdsc_data$Mutation_Status_Nonsilent), "Other", gdsc_data$Mutation_Status_Nonsilent)
gdsc_data$Hugo_Symbol <- factor(gdsc_data$Hugo_Symbol)
gdsc_data$AUC <- as.numeric(gdsc_data$AUC)
gdsc_data$Color_Nonsilent <- ifelse(gdsc_data$Mutation_Status_Nonsilent == "Other", "paleturquoise3", "turquoise4")
gdsc_data$Color_Nonsilent <- factor(gdsc_data$Color_Nonsilent)
gdsc_data <- filter(gdsc_data, !is.na(gdsc_data$AUC))
saveRDS(gdsc_data, "./data_munging/rds/ctrp_data_18Q3.rds", compress = "xz")
ccle_data <- readRDS("./data_munging/rds/ccle_data_18Q3.rds")
ctrp_data <- readRDS("./data_munging/rds/ctrp_data_18Q3.rds")
gdsc_data <- readRDS("./data_munging/rds/gdsc_data_18Q3.rds")
test_gdsc <- gdsc_data %>% group_by(Drug, Hugo_Symbol, Mutation_Status_Nonsilent) %>% tally()

4 Wilcoxon tests: All genes

4.1 CRISPR

Filter for point mutations:

crispr_data_ptmuts <- filter(crispr_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
crispr_data_ptmuts$Keep_PtMut_Tests <- ifelse(crispr_data_ptmuts$Reference_Allele_Length == 1 | is.na(crispr_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(crispr_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
crispr_data_ptmuts <- filter(crispr_data_ptmuts, Keep_PtMut_Tests == TRUE)

test_ptmuts <- filter(crispr_data_ptmuts, is.na(group_general_lineage_name))
test_ptmuts <- filter(crispr_data_ptmuts, Hugo_Symbol == "KRAS")

4.1.1 Grouped by gene

crispr_signif_nonsilent <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_nonsilent <- adj_signif(crispr_signif_nonsilent)
crispr_signif_nonsilent <- crispr_signif_nonsilent[order(crispr_signif_nonsilent$p),]
saveRDS(crispr_signif_nonsilent, "./data_munging/rds/crispr_signif_ptmuts_nonsilent_gene.rds")

# write.table(crispr_signif_nonsilent, file = "~/Desktop/crispr_signif_ptmuts_nonsilent_gene.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_nonsilent <- readRDS("./data_munging/rds/crispr_signif_ptmuts_nonsilent_gene.rds")

knitr::kable(filter(crispr_signif_nonsilent, p < 0.01)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant vs other cell lines, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing non-silent mutant vs other cell lines, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol p p.adj p.format p.signif p.signif.adj
KRAS 0.0000000 0.0000000 < 2e-16 **** ****
TP53 0.0000000 0.0000000 < 2e-16 **** ****
NRAS 0.0000000 0.0000000 < 2e-16 **** ****
BRAF 0.0000000 0.0000000 < 2e-16 **** ****
PIK3CA 0.0000000 0.0000000 1.5e-14 **** ****
PTEN 0.0000000 0.0000000 2.3e-14 **** ****
CTNNB1 0.0000050 0.0122216 5.0e-06 ****
TCERG1 0.0000372 0.0797843 3.7e-05 **** NA
ARID1A 0.0000792 0.1510263 7.9e-05 **** NA
TPR 0.0001525 0.2618368 0.00015 *** NA
FCGBP 0.0002384 0.3497129 0.00024 *** NA
SLC22A9 0.0002503 0.3497129 0.00025 *** NA
GSTM5 0.0002648 0.3497129 0.00026 *** NA
CPSF1 0.0003055 0.3746955 0.00031 *** NA
PIGW 0.0003638 0.4164454 0.00036 *** NA
TLX2 0.0004787 0.5136887 0.00048 *** NA
ARFGAP1 0.0005157 0.5208132 0.00052 *** NA
TAOK2 0.0005481 0.5227559 0.00055 *** NA
CD320 0.0005816 0.5255672 0.00058 *** NA
FBXW7 0.0007199 0.6008266 0.00072 *** NA
ZNF177 0.0007543 0.6008266 0.00075 *** NA
SYNPO2L 0.0007699 0.6008266 0.00077 *** NA
HRAS 0.0008408 0.6276668 0.00084 *** NA
KCNIP4 0.0009472 0.6776073 0.00095 *** NA
PMPCA 0.0010990 0.7063384 0.00110 ** NA
PROM1 0.0011974 0.7063384 0.00120 ** NA
OR52E8 0.0012095 0.7063384 0.00121 ** NA
SOX9 0.0012690 0.7063384 0.00127 ** NA
OR13C4 0.0012702 0.7063384 0.00127 ** NA
TAS1R2 0.0013163 0.7063384 0.00132 ** NA
ZNF439 0.0013227 0.7063384 0.00132 ** NA
ZNF808 0.0013587 0.7063384 0.00136 ** NA
MTMR2 0.0014414 0.7063384 0.00144 ** NA
E2F1 0.0014486 0.7063384 0.00145 ** NA
LPO 0.0014636 0.7063384 0.00146 ** NA
ING2 0.0014811 0.7063384 0.00148 ** NA
MEF2C 0.0015423 0.7156911 0.00154 ** NA
ACSM2B 0.0016213 0.7325365 0.00162 ** NA
OR8D1 0.0017233 0.7363894 0.00172 ** NA
RFC1 0.0019549 0.7363894 0.00195 ** NA
SENP8 0.0019559 0.7363894 0.00196 ** NA
RUVBL1 0.0019950 0.7363894 0.00200 ** NA
CLEC4C 0.0020667 0.7363894 0.00207 ** NA
PCDHA8 0.0020705 0.7363894 0.00207 ** NA
ADAM15 0.0021057 0.7363894 0.00211 ** NA
KPNA6 0.0021334 0.7363894 0.00213 ** NA
POU2F1 0.0022102 0.7363894 0.00221 ** NA
EZH2 0.0022431 0.7363894 0.00224 ** NA
C14orf39 0.0022590 0.7363894 0.00226 ** NA
MDN1 0.0023292 0.7363894 0.00233 ** NA
ATXN2 0.0023450 0.7363894 0.00235 ** NA
OR51T1 0.0023614 0.7363894 0.00236 ** NA
METTL17 0.0023923 0.7363894 0.00239 ** NA
MMRN2 0.0024024 0.7363894 0.00240 ** NA
TUBB2A 0.0025373 0.7363894 0.00254 ** NA
RAB43 0.0025433 0.7363894 0.00254 ** NA
PCDHB15 0.0026029 0.7363894 0.00260 ** NA
DSEL 0.0026072 0.7363894 0.00261 ** NA
CNOT1 0.0026329 0.7363894 0.00263 ** NA
MAT2B 0.0026965 0.7363894 0.00270 ** NA
VHL 0.0027587 0.7363894 0.00276 ** NA
UTP3 0.0028058 0.7363894 0.00281 ** NA
RNF208 0.0028105 0.7363894 0.00281 ** NA
FRMD4B 0.0030803 0.7363894 0.00308 ** NA
SLC26A2 0.0030940 0.7363894 0.00309 ** NA
DPP7 0.0031064 0.7363894 0.00311 ** NA
MYH13 0.0032183 0.7363894 0.00322 ** NA
DIS3L2 0.0032847 0.7363894 0.00328 ** NA
ANKRD32 0.0034117 0.7363894 0.00341 ** NA
PIK3R1 0.0034493 0.7363894 0.00345 ** NA
SCG2 0.0034839 0.7363894 0.00348 ** NA
TRIM8 0.0034895 0.7363894 0.00349 ** NA
TELO2 0.0035001 0.7363894 0.00350 ** NA
HDGFRP2 0.0035382 0.7363894 0.00354 ** NA
CAMK2B 0.0035496 0.7363894 0.00355 ** NA
ETAA1 0.0035617 0.7363894 0.00356 ** NA
ST6GALNAC1 0.0035708 0.7363894 0.00357 ** NA
ZNF493 0.0036128 0.7363894 0.00361 ** NA
SLC38A7 0.0036411 0.7363894 0.00364 ** NA
ZNF107 0.0036424 0.7363894 0.00364 ** NA
KIAA1211L 0.0036773 0.7363894 0.00368 ** NA
SGCD 0.0037645 0.7363894 0.00376 ** NA
KRT83 0.0038147 0.7363894 0.00381 ** NA
EEF2 0.0038473 0.7363894 0.00385 ** NA
SUSD5 0.0039261 0.7363894 0.00393 ** NA
TAAR1 0.0039428 0.7363894 0.00394 ** NA
GOLGA3 0.0040113 0.7363894 0.00401 ** NA
CCNL1 0.0040186 0.7363894 0.00402 ** NA
IQCH 0.0040748 0.7363894 0.00407 ** NA
AVEN 0.0041277 0.7363894 0.00413 ** NA
PLA2G4F 0.0041433 0.7363894 0.00414 ** NA
CD83 0.0041819 0.7363894 0.00418 ** NA
NIPBL 0.0042550 0.7363894 0.00426 ** NA
EMILIN3 0.0042659 0.7363894 0.00427 ** NA
SPHK2 0.0043100 0.7363894 0.00431 ** NA
PSMB4 0.0043587 0.7363894 0.00436 ** NA
RB1 0.0043721 0.7363894 0.00437 ** NA
ACHE 0.0043818 0.7363894 0.00438 ** NA
ZNF135 0.0045686 0.7363894 0.00457 ** NA
CIITA 0.0045986 0.7363894 0.00460 ** NA
BTBD11 0.0046148 0.7363894 0.00461 ** NA
TPP1 0.0046303 0.7363894 0.00463 ** NA
NFE2L1 0.0046446 0.7363894 0.00464 ** NA
KHSRP 0.0046808 0.7363894 0.00468 ** NA
PPP1R1C 0.0047398 0.7363894 0.00474 ** NA
CDC37 0.0047810 0.7363894 0.00478 ** NA
CD200R1 0.0048862 0.7363894 0.00489 ** NA
FOXRED1 0.0049144 0.7363894 0.00491 ** NA
HCRTR1 0.0049160 0.7363894 0.00492 ** NA
ZC3H4 0.0050449 0.7363894 0.00504 ** NA
RBBP9 0.0050826 0.7363894 0.00508 ** NA
ATXN2L 0.0051242 0.7363894 0.00512 ** NA
OGFOD3 0.0051338 0.7363894 0.00513 ** NA
TBC1D22A 0.0052429 0.7363894 0.00524 ** NA
MYO19 0.0052689 0.7363894 0.00527 ** NA
APOBEC1 0.0052779 0.7363894 0.00528 ** NA
OR56A3 0.0052916 0.7363894 0.00529 ** NA
SLC46A2 0.0053108 0.7363894 0.00531 ** NA
STK17B 0.0053176 0.7363894 0.00532 ** NA
C6orf15 0.0053410 0.7363894 0.00534 ** NA
SMPD1 0.0053513 0.7363894 0.00535 ** NA
ANKRD31 0.0054062 0.7363894 0.00541 ** NA
NOL6 0.0054387 0.7363894 0.00544 ** NA
DNAJC5B 0.0057016 0.7363894 0.00570 ** NA
TAS2R60 0.0057034 0.7363894 0.00570 ** NA
SPAG17 0.0057226 0.7363894 0.00572 ** NA
IBA57 0.0057420 0.7363894 0.00574 ** NA
HSD3B7 0.0057475 0.7363894 0.00575 ** NA
MBD3L2 0.0058844 0.7363894 0.00588 ** NA
COPS2 0.0059315 0.7363894 0.00593 ** NA
GRM7 0.0059495 0.7363894 0.00595 ** NA
NBPF15 0.0061326 0.7363894 0.00613 ** NA
CD5L 0.0061772 0.7363894 0.00618 ** NA
STIL 0.0062088 0.7363894 0.00621 ** NA
LMX1A 0.0062097 0.7363894 0.00621 ** NA
ANTXRL 0.0062215 0.7363894 0.00622 ** NA
MMS22L 0.0062232 0.7363894 0.00622 ** NA
SFXN3 0.0062354 0.7363894 0.00624 ** NA
FAM181B 0.0062849 0.7363894 0.00628 ** NA
SMARCB1 0.0062993 0.7363894 0.00630 ** NA
ACBD6 0.0063036 0.7363894 0.00630 ** NA
FBXL20 0.0064106 0.7363894 0.00641 ** NA
NXPH4 0.0064264 0.7363894 0.00643 ** NA
CCNB1 0.0065022 0.7363894 0.00650 ** NA
OR4N2 0.0065455 0.7363894 0.00655 ** NA
RGS12 0.0065563 0.7363894 0.00656 ** NA
SSH2 0.0065847 0.7363894 0.00658 ** NA
CEP76 0.0066070 0.7363894 0.00661 ** NA
MIIP 0.0066145 0.7363894 0.00661 ** NA
FCN3 0.0066248 0.7363894 0.00662 ** NA
TACSTD2 0.0066861 0.7363894 0.00669 ** NA
TSPAN13 0.0067540 0.7363894 0.00675 ** NA
LPCAT4 0.0067758 0.7363894 0.00678 ** NA
KIF11 0.0068236 0.7363894 0.00682 ** NA
IFFO2 0.0068857 0.7363894 0.00689 ** NA
PCK2 0.0068961 0.7363894 0.00690 ** NA
COG3 0.0069083 0.7363894 0.00691 ** NA
TTF1 0.0069153 0.7363894 0.00692 ** NA
DHX35 0.0069214 0.7363894 0.00692 ** NA
LRGUK 0.0069230 0.7363894 0.00692 ** NA
PPM1A 0.0069353 0.7363894 0.00694 ** NA
MSGN1 0.0069483 0.7363894 0.00695 ** NA
CWH43 0.0072297 0.7502064 0.00723 ** NA
PRKCZ 0.0072554 0.7502064 0.00726 ** NA
ACTL8 0.0072969 0.7502064 0.00730 ** NA
SMCR8 0.0073359 0.7502064 0.00734 ** NA
FBXW12 0.0073604 0.7502064 0.00736 ** NA
HSPB2 0.0073660 0.7502064 0.00737 ** NA
PTPRE 0.0073845 0.7502064 0.00738 ** NA
ACTA1 0.0075292 0.7510110 0.00753 ** NA
INTS12 0.0075473 0.7510110 0.00755 ** NA
NAA15 0.0075638 0.7510110 0.00756 ** NA
ARSB 0.0076069 0.7510110 0.00761 ** NA
VPS37B 0.0076704 0.7510110 0.00767 ** NA
SLC30A4 0.0076799 0.7510110 0.00768 ** NA
ATR 0.0076986 0.7510110 0.00770 ** NA
NCR3LG1 0.0078580 0.7605404 0.00786 ** NA
MTMR3 0.0078849 0.7605404 0.00788 ** NA
ACYP2 0.0079841 0.7606029 0.00798 ** NA
PLOD1 0.0080515 0.7606029 0.00805 ** NA
MCTP1 0.0082300 0.7606029 0.00823 ** NA
LILRB2 0.0082617 0.7606029 0.00826 ** NA
H2AFY2 0.0083475 0.7606029 0.00835 ** NA
MRPL13 0.0083762 0.7606029 0.00838 ** NA
PAQR3 0.0084147 0.7606029 0.00841 ** NA
GHITM 0.0084474 0.7606029 0.00845 ** NA
FASTKD2 0.0085145 0.7606029 0.00851 ** NA
ADO 0.0085378 0.7606029 0.00854 ** NA
SAMM50 0.0085631 0.7606029 0.00856 ** NA
MFAP4 0.0085654 0.7606029 0.00857 ** NA
CD163 0.0085663 0.7606029 0.00857 ** NA
ARMC7 0.0085988 0.7606029 0.00860 ** NA
COL8A1 0.0086043 0.7606029 0.00860 ** NA
POLG 0.0086672 0.7606029 0.00867 ** NA
MAML2 0.0087207 0.7606029 0.00872 ** NA
EPS8L3 0.0087956 0.7606029 0.00880 ** NA
MUS81 0.0089063 0.7606029 0.00891 ** NA
ATAD5 0.0089333 0.7606029 0.00893 ** NA
C1orf141 0.0089498 0.7606029 0.00895 ** NA
LRP12 0.0090984 0.7606029 0.00910 ** NA
H3F3A 0.0091122 0.7606029 0.00911 ** NA
COL7A1 0.0091404 0.7606029 0.00914 ** NA
TMEM258 0.0091769 0.7606029 0.00918 ** NA
DNAJC8 0.0093058 0.7606029 0.00931 ** NA
MTSS1L 0.0093383 0.7606029 0.00934 ** NA
KRTAP4-4 0.0093494 0.7606029 0.00935 ** NA
SGK2 0.0093988 0.7606029 0.00940 ** NA
PI4K2A 0.0094006 0.7606029 0.00940 ** NA
SLC12A4 0.0094201 0.7606029 0.00942 ** NA
SLC25A4 0.0094344 0.7606029 0.00943 ** NA
F11R 0.0094708 0.7606029 0.00947 ** NA
LY6G6F 0.0095144 0.7606029 0.00951 ** NA
ZNF330 0.0095171 0.7606029 0.00952 ** NA
NECAB1 0.0095689 0.7606029 0.00957 ** NA
GMCL1 0.0096195 0.7606029 0.00962 ** NA
C16orf58 0.0096729 0.7606029 0.00967 ** NA
ZBTB44 0.0096904 0.7606029 0.00969 ** NA
UTP20 0.0097175 0.7606029 0.00972 ** NA
INHBA 0.0097282 0.7606029 0.00973 ** NA
ZDHHC24 0.0097462 0.7606029 0.00975 ** NA
COPS3 0.0098996 0.7690802 0.00990 ** NA
WDR77 0.0099778 0.7690920 0.00998 ** NA 
wilcox_gene_nonsilent_plot <- ggplot(data = crispr_signif_nonsilent) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_nonsilent_plot

4.1.2 Grouped by gene and lineage

crispr_signif_nonsilent_lineage <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_nonsilent_lineage <- adj_signif(crispr_signif_nonsilent_lineage)
crispr_signif_nonsilent_lineage <- crispr_signif_nonsilent_lineage[order(crispr_signif_nonsilent_lineage$p),]
saveRDS(crispr_signif_nonsilent_lineage, "./data_munging/rds/crispr_signif_ptmuts_nonsilent_lineage.rds")

# write.table(crispr_signif_nonsilent_lineage, file = "~/Desktop/crispr_signif_ptmuts_nonsilent_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_nonsilent_lineage <- readRDS("./data_munging/rds/crispr_signif_ptmuts_nonsilent_lineage.rds")

knitr::kable(filter(crispr_signif_nonsilent_lineage, p < 0.01)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant vs other cell lines by lineage, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
wilcox_lineage_nonsilent_plot <- ggplot(data = crispr_signif_nonsilent_lineage) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_lineage_nonsilent_plot

5 G2P project

5.1 Gene mutation frequency

crispr_data_lvlA <- filter(crispr_data_ptmuts, Hugo_Symbol %in% genes_lvlA)

crispr_data_lvlA_summ <- unique(crispr_data_lvlA[, c("Hugo_Symbol", "N_Nonsilent_Mutant", "N_Nonsilent_Other")])
crispr_data_lvlA_summ$Fraction_Mutant <- crispr_data_lvlA_summ$N_Nonsilent_Mutant / (crispr_data_lvlA_summ$N_Nonsilent_Mutant + crispr_data_lvlA_summ$N_Nonsilent_Other)
crispr_data_lvlA_summ$Percent_Mutant <- crispr_data_lvlA_summ$Fraction_Mutant * 100
# write.table(crispr_data_lvlA_summ, file = "~/Desktop/crispr_data_lvlA_summ_20181003.tsv", quote = FALSE, sep = "\t")

5.2 Wilcoxon tests

5.2.1 CRISPR: Gene

crispr_signif_lvlA <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol"), data = crispr_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_lvlA <- adj_signif(crispr_signif_lvlA)
crispr_signif_lvlA <- crispr_signif_lvlA[order(crispr_signif_lvlA$p),]
saveRDS(crispr_signif_lvlA, "./data_munging/rds/crispr_signif_lvlA_gene.rds")
crispr_signif_lvlA <- readRDS("./data_munging/rds/crispr_signif_lvlA_gene.rds")

crispr_signif_genes_lvlA <- as.character(crispr_signif_lvlA$Hugo_Symbol[0:20])

knitr::kable(filter(crispr_signif_lvlA, p < 0.1)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol p p.adj p.format p.signif p.signif.adj
KRAS 0.0000000 0.0000000 < 2e-16 **** ****
TP53 0.0000000 0.0000000 < 2e-16 **** ****
NRAS 0.0000000 0.0000000 < 2e-16 **** ****
BRAF 0.0000000 0.0000000 < 2e-16 **** ****
PIK3CA 0.0000000 0.0000000 1.5e-14 **** ****
PTEN 0.0000000 0.0000000 2.3e-14 **** ****
CTNNB1 0.0000050 0.0000833 5.0e-06 **** ****
FBXW7 0.0007199 0.0105284 0.00072 ***
HRAS 0.0008408 0.0109309 0.00084 ***
EZH2 0.0022431 0.0262441 0.00224 **
VHL 0.0027587 0.0293428 0.00276 **
TSC2 0.0123492 0.1204049 0.01235
NA
JAK2 0.0164691 0.1450340 0.01647
NA
UGT1A1 0.0173545 0.1450340 0.01735
NA
CDKN2A 0.0251833 0.1833015 0.02518
NA
WHSC1 0.0261222 0.1833015 0.02612
NA
CYP19A1 0.0266336 0.1833015 0.02663
NA
ATM 0.0319423 0.2076249 0.03194
NA
DPYD 0.0395906 0.2437946 0.03959
NA
CREBBP 0.0427407 0.2500332 0.04274
NA
IDH1 0.0565836 0.3152514 0.05658 NA NA
NOTCH2 0.0773788 0.4115146 0.07738 NA NA
CALR 0.0829167 0.4217939 0.08292 NA NA
SRSF2 0.0906149 0.4417474 0.09061 NA NA
GATA2 0.0979336 0.4583294 0.09793 NA NA 
wilcox_gene_lvlA_plot <- ggplot(data = crispr_signif_lvlA) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_lvlA_plot

lvlA_genes_signif <- filter(crispr_data_ptmuts, Hugo_Symbol %in% crispr_signif_genes_lvlA)
lvlA_genes_signif <- merge(lvlA_genes_signif, crispr_signif_lvlA, by = "Hugo_Symbol")
lvlA_genes_signif$Hugo_Symbol <- ordered(lvlA_genes_signif$Hugo_Symbol, levels = crispr_signif_genes_lvlA)
lvlA_genes_signif_color <- as.character(lvlA_genes_signif$Color_Nonsilent)
names(lvlA_genes_signif_color) <- lvlA_genes_signif$Mutation_Status_Nonsilent
lvlA_genes_signif <- merge(lvlA_genes_signif, lvlA_genes_signif %>% group_by(Hugo_Symbol) %>% summarize(Text_y = max(Score)), by = "Hugo_Symbol")

lvlA_genes_text <- unique(data.frame(p.signif.adj = lvlA_genes_signif$p.signif.adj, Hugo_Symbol = lvlA_genes_signif$Hugo_Symbol, Text_y = lvlA_genes_signif$Text_y))
lvlA_genes_text$Hugo_Symbol <- factor(lvlA_genes_text$Hugo_Symbol, levels = crispr_signif_genes_lvlA)

lvlA_signif_genes_plot <- ggplot(data = lvlA_genes_signif, aes(x = Mutation_Status_Nonsilent, y = Score)) +
  facet_wrap(~ Hugo_Symbol, nrow = 2, scales = "free_y") +
  geom_jitter(aes(color = Mutation_Status_Nonsilent), alpha = 0.5, width = 0.3) +
  geom_boxplot(color = "black", fill = NA, outlier.shape = NA) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  scale_color_manual(values = lvlA_genes_signif_color) + 
  geom_text(data = lvlA_genes_text, mapping = aes(x = 1.5, y = Text_y, label = p.signif.adj), nudge_y = 0.2) +
  theme(legend.position = "top") +
  labs(y = "CERES Score",
       x = "Lineage",
       color = "Mutation Status",
       title = "CERES scores for select Level A G2P genes",
       subtitle = "Genes with adjusted p-values < 0.3 are shown.\nBH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001\nGenes are sorted by increasing p-value.")
lvlA_signif_genes_plot

# ggsave("./plots_18Q3/manuscript/crispr_g2p_lvlA_signif_genes_plot.png", lvlA_signif_genes_plot, width = 12, height = 7, units = "in")

5.2.2 CRISPR: Gene and lineage

crispr_signif_lvlA_lineage <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_lvlA_lineage <- adj_signif(crispr_signif_lvlA_lineage)
crispr_signif_lvlA_lineage <- crispr_signif_lvlA_lineage[order(crispr_signif_lvlA_lineage$p),]
saveRDS(crispr_signif_lvlA_lineage, "./data_munging/rds/crispr_signif_lvlA_lineage.rds")

# write.table(crispr_signif_lvlA_lineage, file = "~/Desktop/crispr_signif_lvlA_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_lvlA_lineage <- readRDS("./data_munging/rds/crispr_signif_lvlA_lineage.rds")

knitr::kable(filter(crispr_signif_lvlA_lineage, p < 0.01)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant vs other cell lines by lineage, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing non-silent mutant vs other cell lines by lineage, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol group_general_lineage_name p p.adj p.format p.signif p.signif.adj
KRAS lung cancer 0.0000000 0.0000030 2.5e-09 **** ****
TP53 lung cancer 0.0000086 0.0049934 8.6e-06 **** **
TP53 central nervous system cancer 0.0000504 0.0195615 5.0e-05 ****
KRAS ovarian cancer 0.0001488 0.0433268 0.00015 ***
TP53 ovarian cancer 0.0002837 0.0661128 0.00028 *** NA
NRAS leukemia 0.0005316 0.1032138 0.00053 *** NA
PIK3CA ovarian cancer 0.0008371 0.1365241 0.00084 *** NA
PIK3CA breast cancer 0.0009842 0.1365241 0.00098 *** NA
KRAS colorectal cancer 0.0010547 0.1365241 0.00105 ** NA
NRAS multiple myeloma 0.0013756 0.1602564 0.00138 ** NA
NRAS skin cancer 0.0016637 0.1762022 0.00166 ** NA
TP53 leukemia 0.0023741 0.2304810 0.00237 ** NA
PTEN ovarian cancer 0.0032141 0.2733311 0.00321 ** NA
TP53 colorectal cancer 0.0036603 0.2733311 0.00366 ** NA
TP53 skin cancer 0.0037227 0.2733311 0.00372 ** NA
VHL kidney cancer 0.0037539 0.2733311 0.00375 ** NA
KRAS stomach cancer 0.0040001 0.2741275 0.00400 ** NA
BRAF skin cancer 0.0054870 0.3419998 0.00549 ** NA
SETD2 kidney cancer 0.0056647 0.3419998 0.00566 ** NA
PTEN central nervous system cancer 0.0059869 0.3419998 0.00599 ** NA
ASXL1 colorectal cancer 0.0061648 0.3419998 0.00616 ** NA
PIK3CA colorectal cancer 0.0070506 0.3733617 0.00705 ** NA
PTEN uterine cancer 0.0080389 0.4071865 0.00804 ** NA 
wilcox_lineage_lvlA_plot <- ggplot(data = crispr_signif_lvlA_lineage) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_lineage_lvlA_plot
lvlA_signif <- filter(crispr_data_ptmuts, Hugo_Symbol %in% crispr_signif_genes_lvlA)
lvlA_signif <- merge(lvlA_signif, crispr_signif_lvlA_lineage, by = c("Hugo_Symbol", "group_general_lineage_name"))
lvlA_signif$Hugo_Symbol <- ordered(lvlA_signif$Hugo_Symbol, levels = crispr_signif_genes_lvlA)
lvlA_signif_color <- as.character(lvlA_signif$Color_Nonsilent)
names(lvlA_signif_color) <- lvlA_signif$Mutation_Status_Nonsilent
lvlA_signif <- merge(lvlA_signif, lvlA_signif %>% group_by(Hugo_Symbol) %>% summarize(Text_y = max(Score)), by = "Hugo_Symbol")

lvlA_text <- unique(data.frame(p.signif.adj = lvlA_signif$p.signif.adj, group_general_lineage_name = lvlA_signif$group_general_lineage_name, Hugo_Symbol = lvlA_signif$Hugo_Symbol, Text_y = lvlA_signif$Text_y))
lvlA_text$Hugo_Symbol <- factor(lvlA_text$Hugo_Symbol, levels = crispr_signif_genes_lvlA)

lvlA_signif_lineages_plot <- ggplot(data = lvlA_signif, aes(x = group_general_lineage_name, y = Score)) +
  facet_wrap(~ Hugo_Symbol, nrow = 4, scales = "free_y") +
  geom_point(aes(color = Mutation_Status_Nonsilent), alpha = 0.5) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  scale_color_manual(values = lvlA_signif_color) +
  geom_text(data = lvlA_text, mapping = aes(x = group_general_lineage_name, y = Text_y, label = p.signif.adj), nudge_y = 0.1) +
  theme(legend.position = "top", axis.text.x = element_text(angle = 90, hjust = 1, vjust = 1, size = 10)) +
  labs(y = "CERES Score",
       x = "Lineage",
       color = "Mutation Status",
       title = "CERES score by cell line lineage for significant Level A G2P genes",
       subtitle = "Genes with adjusted p-values < 0.3 are shown.\nBH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001\nGenes are sorted by increasing lineage-agnostic p-value.")
lvlA_signif_lineages_plot

# ggsave("./plots_18Q3/manuscript/crispr_g2p_lvlA_signif_lineages_plot.png", lvlA_signif_lineages_plot, width = 12, height = 15, units = "in")
lvlA_signif_summ <- lvlA_signif %>% group_by(Hugo_Symbol, group_general_lineage_name, Mutation_Status_Nonsilent) %>% tally()
# write.table(lvlA_signif_summ, file = "~/Desktop/lvlA_signif_summ_20181005.tsv", quote = FALSE, sep = "\t")

knitr::kable(lvlA_signif_summ, caption = "Mutant/Other counts for gene-lineage combinations") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
Mutant/Other counts for gene-lineage combinations
Hugo_Symbol group_general_lineage_name Mutation_Status_Nonsilent n
KRAS bone cancer Mutant 1
KRAS bone cancer Other 15
KRAS breast cancer Mutant 2
KRAS breast cancer Other 24
KRAS colorectal cancer Mutant 14
KRAS colorectal cancer Other 13
KRAS esophageal cancer Mutant 1
KRAS esophageal cancer Other 13
KRAS leukemia Mutant 2
KRAS leukemia Other 19
KRAS lung cancer Mutant 22
KRAS lung cancer Other 48
KRAS multiple myeloma Mutant 4
KRAS multiple myeloma Other 12
KRAS ovarian cancer Mutant 9
KRAS ovarian cancer Other 26
KRAS pancreatic cancer Mutant 23
KRAS pancreatic cancer Other 1
KRAS stomach cancer Mutant 5
KRAS stomach cancer Other 10
KRAS urinary bladder cancer Mutant 2
KRAS urinary bladder cancer Other 19
KRAS uterine cancer Mutant 7
KRAS uterine cancer Other 11
TP53 bone cancer Mutant 8
TP53 bone cancer Other 7
TP53 breast cancer Mutant 16
TP53 breast cancer Other 6
TP53 cancer Mutant 7
TP53 cancer Other 10
TP53 central nervous system cancer Mutant 29
TP53 central nervous system cancer Other 13
TP53 colorectal cancer Mutant 18
TP53 colorectal cancer Other 9
TP53 head and neck cancer Mutant 11
TP53 head and neck cancer Other 1
TP53 kidney cancer Mutant 7
TP53 kidney cancer Other 14
TP53 leukemia Mutant 11
TP53 leukemia Other 9
TP53 liver cancer Mutant 10
TP53 liver cancer Other 4
TP53 lung cancer Mutant 53
TP53 lung cancer Other 16
TP53 lymphoma Mutant 7
TP53 lymphoma Other 4
TP53 malignant mesothelioma Mutant 1
TP53 malignant mesothelioma Other 1
TP53 multiple myeloma Mutant 12
TP53 multiple myeloma Other 4
TP53 ovarian cancer Mutant 19
TP53 ovarian cancer Other 12
TP53 pancreatic cancer Mutant 19
TP53 pancreatic cancer Other 3
TP53 peripheral nervous system neoplasm Mutant 4
TP53 peripheral nervous system neoplasm Other 9
TP53 rhabdomyosarcoma Mutant 4
TP53 rhabdomyosarcoma Other 3
TP53 skin cancer Mutant 10
TP53 skin cancer Other 18
TP53 stomach cancer Mutant 13
TP53 stomach cancer Other 2
TP53 urinary bladder cancer Mutant 17
TP53 urinary bladder cancer Other 4
TP53 uterine cancer Mutant 14
TP53 uterine cancer Other 5
NRAS bone cancer Mutant 1
NRAS bone cancer Other 15
NRAS cancer Mutant 2
NRAS cancer Other 16
NRAS central nervous system cancer Mutant 2
NRAS central nervous system cancer Other 43
NRAS head and neck cancer Mutant 1
NRAS head and neck cancer Other 14
NRAS leukemia Mutant 6
NRAS leukemia Other 15
NRAS lung cancer Mutant 5
NRAS lung cancer Other 65
NRAS lymphoma Mutant 2
NRAS lymphoma Other 9
NRAS multiple myeloma Mutant 6
NRAS multiple myeloma Other 10
NRAS peripheral nervous system neoplasm Mutant 2
NRAS peripheral nervous system neoplasm Other 11
NRAS rhabdomyosarcoma Mutant 1
NRAS rhabdomyosarcoma Other 6
NRAS skin cancer Mutant 5
NRAS skin cancer Other 25
NRAS urinary bladder cancer Mutant 4
NRAS urinary bladder cancer Other 17
NRAS uterine cancer Mutant 3
NRAS uterine cancer Other 15
BRAF bone cancer Mutant 1
BRAF bone cancer Other 14
BRAF breast cancer Mutant 3
BRAF breast cancer Other 22
BRAF cancer Mutant 2
BRAF cancer Other 16
BRAF central nervous system cancer Mutant 2
BRAF central nervous system cancer Other 43
BRAF colorectal cancer Mutant 13
BRAF colorectal cancer Other 15
BRAF esophageal cancer Mutant 2
BRAF esophageal cancer Other 12
BRAF liver cancer Mutant 1
BRAF liver cancer Other 15
BRAF lung cancer Mutant 3
BRAF lung cancer Other 66
BRAF multiple myeloma Mutant 2
BRAF multiple myeloma Other 14
BRAF ovarian cancer Mutant 3
BRAF ovarian cancer Other 31
BRAF pancreatic cancer Mutant 2
BRAF pancreatic cancer Other 21
BRAF peripheral nervous system neoplasm Mutant 1
BRAF peripheral nervous system neoplasm Other 12
BRAF skin cancer Mutant 23
BRAF skin cancer Other 8
BRAF stomach cancer Mutant 1
BRAF stomach cancer Other 14
BRAF thyroid cancer Mutant 1
BRAF thyroid cancer Other 2
BRAF urinary bladder cancer Mutant 1
BRAF urinary bladder cancer Other 20
BRAF uterine cancer Mutant 5
BRAF uterine cancer Other 14
PIK3CA breast cancer Mutant 7
PIK3CA breast cancer Other 19
PIK3CA cancer Mutant 1
PIK3CA cancer Other 17
PIK3CA central nervous system cancer Mutant 3
PIK3CA central nervous system cancer Other 42
PIK3CA cervical cancer Mutant 1
PIK3CA cervical cancer Other 1
PIK3CA colorectal cancer Mutant 8
PIK3CA colorectal cancer Other 18
PIK3CA esophageal cancer Mutant 3
PIK3CA esophageal cancer Other 11
PIK3CA head and neck cancer Mutant 3
PIK3CA head and neck cancer Other 12
PIK3CA kidney cancer Mutant 1
PIK3CA kidney cancer Other 21
PIK3CA leukemia Mutant 1
PIK3CA leukemia Other 20
PIK3CA lung cancer Mutant 4
PIK3CA lung cancer Other 65
PIK3CA lymphoma Mutant 1
PIK3CA lymphoma Other 10
PIK3CA multiple myeloma Mutant 1
PIK3CA multiple myeloma Other 15
PIK3CA ovarian cancer Mutant 9
PIK3CA ovarian cancer Other 26
PIK3CA stomach cancer Mutant 3
PIK3CA stomach cancer Other 12
PIK3CA urinary bladder cancer Mutant 8
PIK3CA urinary bladder cancer Other 14
PIK3CA uterine cancer Mutant 12
PIK3CA uterine cancer Other 8
PTEN breast cancer Mutant 8
PTEN breast cancer Other 19
PTEN cancer Mutant 1
PTEN cancer Other 17
PTEN central nervous system cancer Mutant 19
PTEN central nervous system cancer Other 25
PTEN colorectal cancer Mutant 3
PTEN colorectal cancer Other 24
PTEN esophageal cancer Mutant 1
PTEN esophageal cancer Other 13
PTEN head and neck cancer Mutant 1
PTEN head and neck cancer Other 14
PTEN kidney cancer Mutant 3
PTEN kidney cancer Other 19
PTEN leukemia Mutant 4
PTEN leukemia Other 17
PTEN liver cancer Mutant 1
PTEN liver cancer Other 15
PTEN lung cancer Mutant 6
PTEN lung cancer Other 63
PTEN lymphoma Mutant 1
PTEN lymphoma Other 10
PTEN ovarian cancer Mutant 5
PTEN ovarian cancer Other 30
PTEN skin cancer Mutant 5
PTEN skin cancer Other 24
PTEN stomach cancer Mutant 1
PTEN stomach cancer Other 14
PTEN urinary bladder cancer Mutant 2
PTEN urinary bladder cancer Other 19
PTEN uterine cancer Mutant 9
PTEN uterine cancer Other 9
CTNNB1 bone cancer Mutant 1
CTNNB1 bone cancer Other 15
CTNNB1 cancer Mutant 1
CTNNB1 cancer Other 16
CTNNB1 central nervous system cancer Mutant 1
CTNNB1 central nervous system cancer Other 44
CTNNB1 colorectal cancer Mutant 6
CTNNB1 colorectal cancer Other 22
CTNNB1 head and neck cancer Mutant 1
CTNNB1 head and neck cancer Other 15
CTNNB1 leukemia Mutant 2
CTNNB1 leukemia Other 19
CTNNB1 liver cancer Mutant 2
CTNNB1 liver cancer Other 14
CTNNB1 lung cancer Mutant 5
CTNNB1 lung cancer Other 64
CTNNB1 multiple myeloma Mutant 1
CTNNB1 multiple myeloma Other 15
CTNNB1 ovarian cancer Mutant 2
CTNNB1 ovarian cancer Other 33
CTNNB1 skin cancer Mutant 1
CTNNB1 skin cancer Other 28
CTNNB1 stomach cancer Mutant 2
CTNNB1 stomach cancer Other 13
CTNNB1 urinary bladder cancer Mutant 1
CTNNB1 urinary bladder cancer Other 20
CTNNB1 uterine cancer Mutant 4
CTNNB1 uterine cancer Other 15
FBXW7 breast cancer Mutant 1
FBXW7 breast cancer Other 25
FBXW7 colorectal cancer Mutant 6
FBXW7 colorectal cancer Other 23
FBXW7 head and neck cancer Mutant 1
FBXW7 head and neck cancer Other 14
FBXW7 kidney cancer Mutant 1
FBXW7 kidney cancer Other 19
FBXW7 leukemia Mutant 1
FBXW7 leukemia Other 20
FBXW7 lung cancer Mutant 6
FBXW7 lung cancer Other 64
FBXW7 lymphoma Mutant 2
FBXW7 lymphoma Other 9
FBXW7 ovarian cancer Mutant 2
FBXW7 ovarian cancer Other 33
FBXW7 pancreatic cancer Mutant 1
FBXW7 pancreatic cancer Other 22
FBXW7 peripheral nervous system neoplasm Mutant 1
FBXW7 peripheral nervous system neoplasm Other 12
FBXW7 skin cancer Mutant 1
FBXW7 skin cancer Other 28
FBXW7 stomach cancer Mutant 1
FBXW7 stomach cancer Other 14
FBXW7 urinary bladder cancer Mutant 1
FBXW7 urinary bladder cancer Other 20
FBXW7 uterine cancer Mutant 9
FBXW7 uterine cancer Other 11
HRAS breast cancer Mutant 3
HRAS breast cancer Other 23
HRAS esophageal cancer Mutant 1
HRAS esophageal cancer Other 13
HRAS kidney cancer Mutant 1
HRAS kidney cancer Other 21
HRAS lung cancer Mutant 1
HRAS lung cancer Other 68
HRAS skin cancer Mutant 2
HRAS skin cancer Other 27
HRAS urinary bladder cancer Mutant 1
HRAS urinary bladder cancer Other 20
HRAS uterine cancer Mutant 1
HRAS uterine cancer Other 17
EZH2 breast cancer Mutant 1
EZH2 breast cancer Other 25
EZH2 cancer Mutant 1
EZH2 cancer Other 17
EZH2 colorectal cancer Mutant 3
EZH2 colorectal cancer Other 24
EZH2 leukemia Mutant 1
EZH2 leukemia Other 20
EZH2 lung cancer Mutant 2
EZH2 lung cancer Other 67
EZH2 lymphoma Mutant 3
EZH2 lymphoma Other 8
EZH2 multiple myeloma Mutant 1
EZH2 multiple myeloma Other 15
EZH2 pancreatic cancer Mutant 1
EZH2 pancreatic cancer Other 22
EZH2 skin cancer Mutant 3
EZH2 skin cancer Other 26
EZH2 urinary bladder cancer Mutant 1
EZH2 urinary bladder cancer Other 20
EZH2 uterine cancer Mutant 2
EZH2 uterine cancer Other 17
VHL breast cancer Mutant 1
VHL breast cancer Other 25
VHL cancer Mutant 1
VHL cancer Other 17
VHL kidney cancer Mutant 11
VHL kidney cancer Other 7
VHL lung cancer Mutant 2
VHL lung cancer Other 68
VHL uterine cancer Mutant 2
VHL uterine cancer Other 16
TSC2 breast cancer Mutant 1
TSC2 breast cancer Other 25
TSC2 cancer Mutant 1
TSC2 cancer Other 17
TSC2 central nervous system cancer Mutant 1
TSC2 central nervous system cancer Other 43
TSC2 colorectal cancer Mutant 5
TSC2 colorectal cancer Other 22
TSC2 esophageal cancer Mutant 1
TSC2 esophageal cancer Other 13
TSC2 kidney cancer Mutant 1
TSC2 kidney cancer Other 21
TSC2 leukemia Mutant 2
TSC2 leukemia Other 19
TSC2 liver cancer Mutant 2
TSC2 liver cancer Other 14
TSC2 lymphoma Mutant 2
TSC2 lymphoma Other 9
TSC2 multiple myeloma Mutant 2
TSC2 multiple myeloma Other 14
TSC2 pancreatic cancer Mutant 2
TSC2 pancreatic cancer Other 21
TSC2 peripheral nervous system neoplasm Mutant 1
TSC2 peripheral nervous system neoplasm Other 12
TSC2 rhabdomyosarcoma Mutant 1
TSC2 rhabdomyosarcoma Other 6
TSC2 stomach cancer Mutant 2
TSC2 stomach cancer Other 13
TSC2 uterine cancer Mutant 9
TSC2 uterine cancer Other 10
JAK2 colorectal cancer Mutant 1
JAK2 colorectal cancer Other 27
JAK2 esophageal cancer Mutant 1
JAK2 esophageal cancer Other 13
JAK2 leukemia Mutant 1
JAK2 leukemia Other 20
JAK2 lung cancer Mutant 2
JAK2 lung cancer Other 67
JAK2 lymphoma Mutant 1
JAK2 lymphoma Other 10
JAK2 ovarian cancer Mutant 1
JAK2 ovarian cancer Other 34
JAK2 urinary bladder cancer Mutant 2
JAK2 urinary bladder cancer Other 19
JAK2 uterine cancer Mutant 5
JAK2 uterine cancer Other 13
UGT1A1 bone cancer Mutant 2
UGT1A1 bone cancer Other 14
UGT1A1 colorectal cancer Mutant 1
UGT1A1 colorectal cancer Other 25
UGT1A1 esophageal cancer Mutant 1
UGT1A1 esophageal cancer Other 13
UGT1A1 kidney cancer Mutant 1
UGT1A1 kidney cancer Other 21
UGT1A1 lung cancer Mutant 2
UGT1A1 lung cancer Other 67
UGT1A1 skin cancer Mutant 2
UGT1A1 skin cancer Other 28
UGT1A1 stomach cancer Mutant 1
UGT1A1 stomach cancer Other 14
UGT1A1 uterine cancer Mutant 3
UGT1A1 uterine cancer Other 16
CDKN2A cancer Mutant 2
CDKN2A cancer Other 17
CDKN2A colorectal cancer Mutant 2
CDKN2A colorectal cancer Other 25
CDKN2A esophageal cancer Mutant 2
CDKN2A esophageal cancer Other 12
CDKN2A head and neck cancer Mutant 6
CDKN2A head and neck cancer Other 9
CDKN2A leukemia Mutant 1
CDKN2A leukemia Other 20
CDKN2A liver cancer Mutant 1
CDKN2A liver cancer Other 15
CDKN2A lung cancer Mutant 11
CDKN2A lung cancer Other 59
CDKN2A lymphoma Mutant 1
CDKN2A lymphoma Other 10
CDKN2A multiple myeloma Mutant 1
CDKN2A multiple myeloma Other 15
CDKN2A ovarian cancer Mutant 4
CDKN2A ovarian cancer Other 31
CDKN2A pancreatic cancer Mutant 5
CDKN2A pancreatic cancer Other 17
CDKN2A peripheral nervous system neoplasm Mutant 1
CDKN2A peripheral nervous system neoplasm Other 12
CDKN2A rhabdomyosarcoma Mutant 3
CDKN2A rhabdomyosarcoma Other 4
CDKN2A skin cancer Mutant 9
CDKN2A skin cancer Other 21
CDKN2A stomach cancer Mutant 1
CDKN2A stomach cancer Other 14
CDKN2A thyroid cancer Mutant 1
CDKN2A thyroid cancer Other 3
CDKN2A urinary bladder cancer Mutant 2
CDKN2A urinary bladder cancer Other 18
CDKN2A uterine cancer Mutant 3
CDKN2A uterine cancer Other 17
WHSC1 bone cancer Mutant 1
WHSC1 bone cancer Other 15
WHSC1 cancer Mutant 1
WHSC1 cancer Other 17
WHSC1 colorectal cancer Mutant 6
WHSC1 colorectal cancer Other 21
WHSC1 leukemia Mutant 2
WHSC1 leukemia Other 19
WHSC1 lung cancer Mutant 2
WHSC1 lung cancer Other 67
WHSC1 lymphoma Mutant 1
WHSC1 lymphoma Other 10
WHSC1 multiple myeloma Mutant 1
WHSC1 multiple myeloma Other 15
WHSC1 pancreatic cancer Mutant 1
WHSC1 pancreatic cancer Other 22
WHSC1 skin cancer Mutant 3
WHSC1 skin cancer Other 26
WHSC1 thyroid cancer Mutant 1
WHSC1 thyroid cancer Other 2
WHSC1 urinary bladder cancer Mutant 2
WHSC1 urinary bladder cancer Other 19
WHSC1 uterine cancer Mutant 3
WHSC1 uterine cancer Other 15
CYP19A1 breast cancer Mutant 1
CYP19A1 breast cancer Other 25
CYP19A1 esophageal cancer Mutant 1
CYP19A1 esophageal cancer Other 13
CYP19A1 lymphoma Mutant 1
CYP19A1 lymphoma Other 10
CYP19A1 peripheral nervous system neoplasm Mutant 1
CYP19A1 peripheral nervous system neoplasm Other 12
CYP19A1 stomach cancer Mutant 1
CYP19A1 stomach cancer Other 14
CYP19A1 urinary bladder cancer Mutant 1
CYP19A1 urinary bladder cancer Other 20
CYP19A1 uterine cancer Mutant 2
CYP19A1 uterine cancer Other 16
ATM breast cancer Mutant 3
ATM breast cancer Other 23
ATM cancer Mutant 2
ATM cancer Other 15
ATM central nervous system cancer Mutant 3
ATM central nervous system cancer Other 43
ATM colorectal cancer Mutant 6
ATM colorectal cancer Other 21
ATM esophageal cancer Mutant 1
ATM esophageal cancer Other 13
ATM head and neck cancer Mutant 1
ATM head and neck cancer Other 14
ATM kidney cancer Mutant 4
ATM kidney cancer Other 18
ATM leukemia Mutant 3
ATM leukemia Other 19
ATM liver cancer Mutant 2
ATM liver cancer Other 14
ATM lung cancer Mutant 16
ATM lung cancer Other 54
ATM lymphoma Mutant 3
ATM lymphoma Other 8
ATM multiple myeloma Mutant 4
ATM multiple myeloma Other 12
ATM ovarian cancer Mutant 9
ATM ovarian cancer Other 27
ATM pancreatic cancer Mutant 1
ATM pancreatic cancer Other 22
ATM peripheral nervous system neoplasm Mutant 2
ATM peripheral nervous system neoplasm Other 12
ATM rhabdomyosarcoma Mutant 1
ATM rhabdomyosarcoma Other 6
ATM skin cancer Mutant 5
ATM skin cancer Other 23
ATM stomach cancer Mutant 2
ATM stomach cancer Other 13
ATM thyroid cancer Mutant 2
ATM thyroid cancer Other 1
ATM urinary bladder cancer Mutant 6
ATM urinary bladder cancer Other 16
ATM uterine cancer Mutant 12
ATM uterine cancer Other 9
DPYD bone cancer Mutant 1
DPYD bone cancer Other 15
DPYD breast cancer Mutant 2
DPYD breast cancer Other 24
DPYD central nervous system cancer Mutant 1
DPYD central nervous system cancer Other 44
DPYD colorectal cancer Mutant 4
DPYD colorectal cancer Other 24
DPYD head and neck cancer Mutant 1
DPYD head and neck cancer Other 14
DPYD kidney cancer Mutant 2
DPYD kidney cancer Other 20
DPYD leukemia Mutant 1
DPYD leukemia Other 21
DPYD liver cancer Mutant 1
DPYD liver cancer Other 15
DPYD lung cancer Mutant 4
DPYD lung cancer Other 65
DPYD lymphoma Mutant 1
DPYD lymphoma Other 10
DPYD multiple myeloma Mutant 1
DPYD multiple myeloma Other 15
DPYD ovarian cancer Mutant 2
DPYD ovarian cancer Other 33
DPYD rhabdomyosarcoma Mutant 1
DPYD rhabdomyosarcoma Other 6
DPYD skin cancer Mutant 4
DPYD skin cancer Other 25
DPYD urinary bladder cancer Mutant 1
DPYD urinary bladder cancer Other 20
DPYD uterine cancer Mutant 2
DPYD uterine cancer Other 16
CREBBP breast cancer Mutant 3
CREBBP breast cancer Other 23
CREBBP cancer Mutant 1
CREBBP cancer Other 16
CREBBP central nervous system cancer Mutant 5
CREBBP central nervous system cancer Other 40
CREBBP colorectal cancer Mutant 7
CREBBP colorectal cancer Other 22
CREBBP esophageal cancer Mutant 1
CREBBP esophageal cancer Other 12
CREBBP head and neck cancer Mutant 5
CREBBP head and neck cancer Other 10
CREBBP kidney cancer Mutant 1
CREBBP kidney cancer Other 21
CREBBP leukemia Mutant 6
CREBBP leukemia Other 14
CREBBP liver cancer Mutant 1
CREBBP liver cancer Other 15
CREBBP lung cancer Mutant 8
CREBBP lung cancer Other 61
CREBBP lymphoma Mutant 3
CREBBP lymphoma Other 8
CREBBP ovarian cancer Mutant 6
CREBBP ovarian cancer Other 30
CREBBP pancreatic cancer Mutant 1
CREBBP pancreatic cancer Other 22
CREBBP peripheral nervous system neoplasm Mutant 1
CREBBP peripheral nervous system neoplasm Other 12
CREBBP rhabdomyosarcoma Mutant 1
CREBBP rhabdomyosarcoma Other 6
CREBBP skin cancer Mutant 2
CREBBP skin cancer Other 28
CREBBP urinary bladder cancer Mutant 2
CREBBP urinary bladder cancer Other 20
CREBBP uterine cancer Mutant 9
CREBBP uterine cancer Other 10

5.2.3 CCLE: Gene and drug

ccle_data_ptmuts <- filter(ccle_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
ccle_data_ptmuts$Keep_PtMut_Tests <- ifelse(ccle_data_ptmuts$Reference_Allele_Length == 1 | is.na(ccle_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(ccle_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
ccle_data_ptmuts <- filter(ccle_data_ptmuts, Keep_PtMut_Tests == TRUE)
ccle_data_lvlA <- filter(ccle_data_ptmuts, Hugo_Symbol %in% genes_lvlA)
ccle_signif_lvlA_ByDrug <- lapply(unique(ccle_data_lvlA$Drug), WilcoxonByDrug, dataset = ccle_data_lvlA, data_name = "CCLE")
names(ccle_signif_lvlA_ByDrug) <- unique(ccle_data_lvlA$Drug)
saveRDS(ccle_signif_lvlA_ByDrug, "./data_munging/rds/ccle_signif_lvlA_ByDrug.rds")

ccle_signif_lvlA <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = c("Drug", "Hugo_Symbol"), data = ccle_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
ccle_signif_lvlA <- adj_signif(ccle_signif_lvlA)
ccle_signif_lvlA <- ccle_signif_lvlA[order(ccle_signif_lvlA$p),]
saveRDS(ccle_signif_lvlA, "./data_munging/rds/ccle_signif_lvlA_gene.rds")
ccle_signif_lvlA <- readRDS("./data_munging/rds/ccle_signif_lvlA_gene.rds")

knitr::kable(ccle_signif_lvlA[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CCLE: Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
BRAF selumetinib 0.0000000 0.0000316 4.8e-08 **** ****
NRAS selumetinib 0.0000274 0.0089603 2.7e-05 **** **
KRAS selumetinib 0.0004853 0.1058056 0.00049 *** NA
ETV6 selumetinib 0.0021320 0.3485845 0.00213 ** NA
CDKN2A selumetinib 0.0042499 0.5558840 0.00425 ** NA
JAK1 irinotecan 0.0074451 0.6534999 0.00745 ** NA
FBXW7 irinotecan 0.0090628 0.6534999 0.00906 ** NA
PRPF8 selumetinib 0.0099673 0.6534999 0.00997 ** NA
PAX8 nilotinib 0.0106011 0.6534999 0.01060
NA
KRAS irinotecan 0.0107870 0.6534999 0.01079
NA
ASXL1 selumetinib 0.0111516 0.6534999 0.01115
NA
ERBB3 lapatinib 0.0129696 0.6534999 0.01297
NA
FLT3 irinotecan 0.0133264 0.6534999 0.01333
NA
ASXL1 lapatinib 0.0139893 0.6534999 0.01399
NA
MPL selumetinib 0.0172826 0.7436311 0.01728
NA
SETD2 irinotecan 0.0181928 0.7436311 0.01819
NA
ERBB3 nilotinib 0.0219026 0.8139309 0.02190
NA
BRAF erlotinib 0.0224018 0.8139309 0.02240
NA
XPO1 nilotinib 0.0251623 0.8661135 0.02516
NA
CD274 erlotinib 0.0296833 0.8817295 0.02968
NA
KIT lapatinib 0.0299886 0.8817295 0.02999
NA
XPO1 lapatinib 0.0354732 0.8817295 0.03547
NA
ERBB2 erlotinib 0.0361008 0.8817295 0.03610
NA
ZRSR2 irinotecan 0.0372753 0.8817295 0.03728
NA
RUNX1 selumetinib 0.0372876 0.8817295 0.03729
NA
PDGFB erlotinib 0.0406263 0.8817295 0.04063
NA
TSC2 irinotecan 0.0425134 0.8817295 0.04251
NA
MAP2K2 nilotinib 0.0477901 0.8817295 0.04779
NA
WT1 lapatinib 0.0500201 0.8817295 0.05002 NA NA
ERBB2 lapatinib 0.0500292 0.8817295 0.05003 NA NA
NOTCH2 erlotinib 0.0501837 0.8817295 0.05018 NA NA
CD274 lapatinib 0.0504368 0.8817295 0.05044 NA NA
MYCN erlotinib 0.0511362 0.8817295 0.05114 NA NA
DDIT3 irinotecan 0.0544500 0.8817295 0.05445 NA NA
EED irinotecan 0.0574304 0.8817295 0.05743 NA NA
UGT1A1 nilotinib 0.0574932 0.8817295 0.05749 NA NA
CRLF2 erlotinib 0.0586240 0.8817295 0.05862 NA NA
WHSC1 selumetinib 0.0603852 0.8817295 0.06039 NA NA
NOTCH2 irinotecan 0.0615243 0.8817295 0.06152 NA NA
DNAJB1 erlotinib 0.0624342 0.8817295 0.06243 NA NA
IDH1 erlotinib 0.0637744 0.8817295 0.06377 NA NA
ROS1 lapatinib 0.0638294 0.8817295 0.06383 NA NA
PTEN selumetinib 0.0676687 0.8817295 0.06767 NA NA
CEBPA lapatinib 0.0701353 0.8817295 0.07014 NA NA
JAK2 irinotecan 0.0704563 0.8817295 0.07046 NA NA
PIGA erlotinib 0.0708932 0.8817295 0.07089 NA NA
CALR erlotinib 0.0711196 0.8817295 0.07112 NA NA
MGMT lapatinib 0.0716529 0.8817295 0.07165 NA NA
CXCR4 erlotinib 0.0741100 0.8817295 0.07411 NA NA
WHSC1 nilotinib 0.0752617 0.8817295 0.07526 NA NA
CRLF2 lapatinib 0.0760006 0.8817295 0.07600 NA NA
RAD21 lapatinib 0.0773127 0.8817295 0.07731 NA NA
SMO selumetinib 0.0780507 0.8817295 0.07805 NA NA
IDH1 selumetinib 0.0795440 0.8817295 0.07954 NA NA
BRCA2 selumetinib 0.0801455 0.8817295 0.08015 NA NA
BRAF nilotinib 0.0823341 0.8817295 0.08233 NA NA
ZRSR2 nilotinib 0.0823935 0.8817295 0.08239 NA NA
G6PD selumetinib 0.0848649 0.8817295 0.08486 NA NA
CDK4 irinotecan 0.0868856 0.8817295 0.08689 NA NA
MAP2K1 nilotinib 0.0869990 0.8817295 0.08700 NA NA
FGFR2 irinotecan 0.0873862 0.8817295 0.08739 NA NA
DNMT3A lapatinib 0.0910216 0.8817295 0.09102 NA NA
CBLB nilotinib 0.0920561 0.8817295 0.09206 NA NA
IDH2 selumetinib 0.0923191 0.8817295 0.09232 NA NA
ROS1 erlotinib 0.0964090 0.8817295 0.09641 NA NA
NCOA2 nilotinib 0.0971203 0.8817295 0.09712 NA NA
G6PD nilotinib 0.0978349 0.8817295 0.09783 NA NA
AKT1 irinotecan 0.0995560 0.8817295 0.09956 NA NA
PIGA nilotinib 0.1007178 0.8817295 0.10072 NA NA
STAG2 erlotinib 0.1047686 0.8817295 0.10477 NA NA
CBLB lapatinib 0.1059300 0.8817295 0.10593 NA NA
SRSF2 lapatinib 0.1089131 0.8817295 0.10891 NA NA
AKT3 selumetinib 0.1094130 0.8817295 0.10941 NA NA
EZH2 selumetinib 0.1105216 0.8817295 0.11052 NA NA
PTCH1 selumetinib 0.1105610 0.8817295 0.11056 NA NA
TET2 lapatinib 0.1133220 0.8817295 0.11332 NA NA
BCOR selumetinib 0.1155220 0.8817295 0.11552 NA NA
DNAJB1 lapatinib 0.1176422 0.8817295 0.11764 NA NA
GNAS selumetinib 0.1198231 0.8817295 0.11982 NA NA
U2AF1 erlotinib 0.1205628 0.8817295 0.12056 NA NA
CDC73 irinotecan 0.1207285 0.8817295 0.12073 NA NA
CTLA4 erlotinib 0.1220555 0.8817295 0.12206 NA NA
BRAF irinotecan 0.1223433 0.8817295 0.12234 NA NA
EML4 irinotecan 0.1225636 0.8817295 0.12256 NA NA
EML4 erlotinib 0.1250336 0.8817295 0.12503 NA NA
PDGFRA selumetinib 0.1271928 0.8817295 0.12719 NA NA
ZRSR2 selumetinib 0.1277334 0.8817295 0.12773 NA NA
NOTCH1 lapatinib 0.1297020 0.8817295 0.12970 NA NA
MAP2K2 erlotinib 0.1309379 0.8817295 0.13094 NA NA
AKT1 nilotinib 0.1319214 0.8817295 0.13192 NA NA
SMC1A erlotinib 0.1324733 0.8817295 0.13247 NA NA
ATM irinotecan 0.1329381 0.8817295 0.13294 NA NA
TSC2 lapatinib 0.1353477 0.8817295 0.13535 NA NA
KMT2A selumetinib 0.1379561 0.8817295 0.13796 NA NA
PHF6 erlotinib 0.1395872 0.8817295 0.13959 NA NA
GATA2 erlotinib 0.1428705 0.8817295 0.14287 NA NA
BRCA2 lapatinib 0.1454060 0.8817295 0.14541 NA NA
SMO erlotinib 0.1461317 0.8817295 0.14613 NA NA
AR erlotinib 0.1463011 0.8817295 0.14630 NA NA
DNMT3A selumetinib 0.1475871 0.8817295 0.14759 NA NA
PDGFRA erlotinib 0.1494369 0.8817295 0.14944 NA NA
CD274 nilotinib 0.1500406 0.8817295 0.15004 NA NA
CSF3R selumetinib 0.1508988 0.8817295 0.15090 NA NA
ERBB3 erlotinib 0.1517945 0.8817295 0.15179 NA NA
CALR lapatinib 0.1520641 0.8817295 0.15206 NA NA
PDGFRA lapatinib 0.1524894 0.8817295 0.15249 NA NA
BRAF lapatinib 0.1535431 0.8817295 0.15354 NA NA
WT1 erlotinib 0.1553226 0.8817295 0.15532 NA NA
MGMT erlotinib 0.1554862 0.8817295 0.15549 NA NA
EML4 nilotinib 0.1557059 0.8817295 0.15571 NA NA
FANCL lapatinib 0.1575032 0.8817295 0.15750 NA NA
GNB1 irinotecan 0.1580732 0.8817295 0.15807 NA NA
RET lapatinib 0.1587070 0.8817295 0.15871 NA NA
SF1 lapatinib 0.1589503 0.8817295 0.15895 NA NA
CBLB erlotinib 0.1604334 0.8817295 0.16043 NA NA
ERBB4 irinotecan 0.1615181 0.8817295 0.16152 NA NA
ESR1 irinotecan 0.1628356 0.8817295 0.16284 NA NA
STAG2 selumetinib 0.1648011 0.8817295 0.16480 NA NA
ERBB4 nilotinib 0.1674099 0.8817295 0.16741 NA NA
GNA11 nilotinib 0.1690832 0.8817295 0.16908 NA NA
CTLA4 lapatinib 0.1692151 0.8817295 0.16922 NA NA
CTLA4 irinotecan 0.1702373 0.8817295 0.17024 NA NA
DPYD nilotinib 0.1716871 0.8817295 0.17169 NA NA
MET erlotinib 0.1724618 0.8817295 0.17246 NA NA
JAK2 selumetinib 0.1725059 0.8817295 0.17251 NA NA
SF1 erlotinib 0.1731756 0.8817295 0.17318 NA NA
JAK1 selumetinib 0.1737020 0.8817295 0.17370 NA NA
CDC73 nilotinib 0.1737485 0.8817295 0.17375 NA NA
PIK3CA selumetinib 0.1739191 0.8817295 0.17392 NA NA
ASXL1 erlotinib 0.1754940 0.8828700 0.17549 NA NA
TPMT irinotecan 0.1771488 0.8843918 0.17715 NA NA
IDH2 nilotinib 0.1844993 0.8878919 0.18450 NA NA
XPO1 erlotinib 0.1879584 0.8878919 0.18796 NA NA
PDGFB lapatinib 0.1902003 0.8878919 0.19020 NA NA
PAX5 irinotecan 0.1910949 0.8878919 0.19109 NA NA
SRSF2 selumetinib 0.1939112 0.8878919 0.19391 NA NA
TP53 lapatinib 0.1940528 0.8878919 0.19405 NA NA
IKZF1 irinotecan 0.1945005 0.8878919 0.19450 NA NA
PHF6 nilotinib 0.1953337 0.8878919 0.19533 NA NA
CD79B irinotecan 0.1953386 0.8878919 0.19534 NA NA
FBXW7 nilotinib 0.1956027 0.8878919 0.19560 NA NA
EED nilotinib 0.1957988 0.8878919 0.19580 NA NA
ATM nilotinib 0.1967220 0.8878919 0.19672 NA NA
CEBPA nilotinib 0.1968300 0.8878919 0.19683 NA NA
DNAJB1 nilotinib 0.2009226 0.8878919 0.20092 NA NA
CSF3R erlotinib 0.2026368 0.8878919 0.20264 NA NA
IKZF1 nilotinib 0.2030879 0.8878919 0.20309 NA NA
FBXW7 lapatinib 0.2051047 0.8878919 0.20510 NA NA
JAK2 erlotinib 0.2076226 0.8878919 0.20762 NA NA
FGFR2 selumetinib 0.2084067 0.8878919 0.20841 NA NA
GNAQ lapatinib 0.2084358 0.8878919 0.20844 NA NA
IDH2 erlotinib 0.2087321 0.8878919 0.20873 NA NA
CTCF erlotinib 0.2093239 0.8878919 0.20932 NA NA
JAK3 nilotinib 0.2106747 0.8878919 0.21067 NA NA
MYCN lapatinib 0.2118132 0.8878919 0.21181 NA NA
CREBBP lapatinib 0.2121723 0.8878919 0.21217 NA NA
PDGFRB irinotecan 0.2131484 0.8878919 0.21315 NA NA
CDK6 nilotinib 0.2163351 0.8935947 0.21634 NA NA
ETV6 lapatinib 0.2197037 0.8935947 0.21970 NA NA
CALR nilotinib 0.2199033 0.8935947 0.21990 NA NA
PTEN erlotinib 0.2232818 0.8935947 0.22328 NA NA
PDCD1 lapatinib 0.2263464 0.8935947 0.22635 NA NA
PRPF8 nilotinib 0.2273928 0.8935947 0.22739 NA NA
MDM2 lapatinib 0.2279558 0.8935947 0.22796 NA NA
EGFR irinotecan 0.2306603 0.8935947 0.23066 NA NA
FANCL selumetinib 0.2375039 0.8935947 0.23750 NA NA
CREBBP irinotecan 0.2415640 0.8935947 0.24156 NA NA
U2AF1 lapatinib 0.2430493 0.8935947 0.24305 NA NA
MGMT irinotecan 0.2444998 0.8935947 0.24450 NA NA
ERBB2 nilotinib 0.2469369 0.8935947 0.24694 NA NA
JAK2 lapatinib 0.2481605 0.8935947 0.24816 NA NA
FGFR2 erlotinib 0.2494792 0.8935947 0.24948 NA NA
NOTCH1 selumetinib 0.2510449 0.8935947 0.25104 NA NA
NRAS lapatinib 0.2515364 0.8935947 0.25154 NA NA
BRCA2 irinotecan 0.2519045 0.8935947 0.25190 NA NA
SETBP1 irinotecan 0.2535542 0.8935947 0.25355 NA NA
FANCL nilotinib 0.2544008 0.8935947 0.25440 NA NA
PRPF40B irinotecan 0.2545052 0.8935947 0.25451 NA NA
VHL selumetinib 0.2554789 0.8935947 0.25548 NA NA
EED lapatinib 0.2560293 0.8935947 0.25603 NA NA
DPYD irinotecan 0.2565617 0.8935947 0.25656 NA NA
CREBBP erlotinib 0.2568307 0.8935947 0.25683 NA NA
PTEN nilotinib 0.2586912 0.8935947 0.25869 NA NA
ZRSR2 erlotinib 0.2598896 0.8935947 0.25989 NA NA
PDGFB nilotinib 0.2614178 0.8935947 0.26142 NA NA
NPM1 lapatinib 0.2652151 0.8935947 0.26522 NA NA
PML lapatinib 0.2673135 0.8935947 0.26731 NA NA
U2AF1 irinotecan 0.2686219 0.8935947 0.26862 NA NA
TP53 irinotecan 0.2699212 0.8935947 0.26992 NA NA
DNMT3A irinotecan 0.2699431 0.8935947 0.26994 NA NA
GNB1 nilotinib 0.2703894 0.8935947 0.27039 NA NA
VHL lapatinib 0.2715493 0.8935947 0.27155 NA NA
IL7R irinotecan 0.2748197 0.8935947 0.27482 NA NA
NOTCH2 lapatinib 0.2759280 0.8935947 0.27593 NA NA
ETV6 irinotecan 0.2759762 0.8935947 0.27598 NA NA
PAX8 selumetinib 0.2784348 0.8935947 0.27843 NA NA
GNAS irinotecan 0.2798045 0.8935947 0.27980 NA NA
SMC3 selumetinib 0.2800304 0.8935947 0.28003 NA NA
CEBPA erlotinib 0.2814510 0.8935947 0.28145 NA NA
CRLF2 nilotinib 0.2819017 0.8935947 0.28190 NA NA
GNA11 irinotecan 0.2837623 0.8935947 0.28376 NA NA
GNAQ erlotinib 0.2841793 0.8935947 0.28418 NA NA
RPL10 nilotinib 0.2850268 0.8935947 0.28503 NA NA
GATA1 selumetinib 0.2877975 0.8935947 0.28780 NA NA
EGF erlotinib 0.2884798 0.8935947 0.28848 NA NA
RIT1 selumetinib 0.2890366 0.8935947 0.28904 NA NA
RAD21 erlotinib 0.2894193 0.8935947 0.28942 NA NA
STAG2 irinotecan 0.2896816 0.8935947 0.28968 NA NA
BRCA2 erlotinib 0.2904280 0.8935947 0.29043 NA NA
KRAS nilotinib 0.2905710 0.8935947 0.29057 NA NA
IDH1 nilotinib 0.2908172 0.8935947 0.29082 NA NA
RIT1 irinotecan 0.2916381 0.8935947 0.29164 NA NA
GATA3 irinotecan 0.2950313 0.8935947 0.29503 NA NA
SETBP1 nilotinib 0.2960817 0.8935947 0.29608 NA NA
PIK3CA nilotinib 0.2965860 0.8935947 0.29659 NA NA
FLCN lapatinib 0.2981455 0.8935947 0.29815 NA NA
NT5C2 selumetinib 0.2993317 0.8935947 0.29933 NA NA
CDK4 erlotinib 0.3023854 0.8935947 0.30239 NA NA
DDIT3 nilotinib 0.3025069 0.8935947 0.30251 NA NA
TSC1 selumetinib 0.3026265 0.8935947 0.30263 NA NA
CBL selumetinib 0.3063751 0.8935947 0.30638 NA NA
PML erlotinib 0.3071538 0.8935947 0.30715 NA NA
CDK4 nilotinib 0.3095790 0.8935947 0.30958 NA NA
SH2B3 nilotinib 0.3095790 0.8935947 0.30958 NA NA
SMC3 nilotinib 0.3146584 0.8935947 0.31466 NA NA
RET selumetinib 0.3162948 0.8935947 0.31629 NA NA
GATA1 nilotinib 0.3176333 0.8935947 0.31763 NA NA
CALR irinotecan 0.3188346 0.8935947 0.31883 NA NA
PIK3CA irinotecan 0.3207286 0.8935947 0.32073 NA NA
MAP2K2 selumetinib 0.3219772 0.8935947 0.32198 NA NA
JAK2 nilotinib 0.3242397 0.8935947 0.32424 NA NA
STAT3 nilotinib 0.3252695 0.8935947 0.32527 NA NA
GATA1 lapatinib 0.3258106 0.8935947 0.32581 NA NA
NCOA2 lapatinib 0.3280718 0.8935947 0.32807 NA NA
CYP19A1 irinotecan 0.3281397 0.8935947 0.32814 NA NA
PDCD1 erlotinib 0.3307646 0.8935947 0.33076 NA NA
RAD21 irinotecan 0.3328997 0.8935947 0.33290 NA NA
CDC73 erlotinib 0.3331184 0.8935947 0.33312 NA NA
GNA11 erlotinib 0.3332076 0.8935947 0.33321 NA NA
STAT3 lapatinib 0.3335387 0.8935947 0.33354 NA NA
EED erlotinib 0.3343486 0.8935947 0.33435 NA NA
EZH2 lapatinib 0.3363420 0.8935947 0.33634 NA NA
STAT3 irinotecan 0.3391154 0.8935947 0.33912 NA NA
GATA2 selumetinib 0.3395397 0.8935947 0.33954 NA NA
PAX8 irinotecan 0.3425029 0.8935947 0.34250 NA NA
KRAS erlotinib 0.3430622 0.8935947 0.34306 NA NA
CD79B nilotinib 0.3432244 0.8935947 0.34322 NA NA
ASXL1 nilotinib 0.3452112 0.8935947 0.34521 NA NA
GATA3 selumetinib 0.3459306 0.8935947 0.34593 NA NA
PIK3CA erlotinib 0.3473764 0.8935947 0.34738 NA NA
GATA2 irinotecan 0.3492471 0.8935947 0.34925 NA NA
BTK selumetinib 0.3507388 0.8935947 0.35074 NA NA
IDH1 lapatinib 0.3512958 0.8935947 0.35130 NA NA
EGF nilotinib 0.3535275 0.8935947 0.35353 NA NA
FGFR1 lapatinib 0.3538617 0.8935947 0.35386 NA NA
SF1 irinotecan 0.3571830 0.8935947 0.35718 NA NA
EML4 lapatinib 0.3576785 0.8935947 0.35768 NA NA
MET irinotecan 0.3595819 0.8935947 0.35958 NA NA
SMO lapatinib 0.3610953 0.8935947 0.36110 NA NA
CYP19A1 nilotinib 0.3614358 0.8935947 0.36144 NA NA
BRCA1 erlotinib 0.3656704 0.8935947 0.36567 NA NA
CYP19A1 selumetinib 0.3657355 0.8935947 0.36574 NA NA
MYD88 irinotecan 0.3660517 0.8935947 0.36605 NA NA
AR irinotecan 0.3668667 0.8935947 0.36687 NA NA
ETV6 erlotinib 0.3694510 0.8935947 0.36945 NA NA
RPL10 lapatinib 0.3697756 0.8935947 0.36978 NA NA
CEBPA selumetinib 0.3714072 0.8935947 0.37141 NA NA
KRAS lapatinib 0.3717079 0.8935947 0.37171 NA NA
TP53 selumetinib 0.3730400 0.8935947 0.37304 NA NA
CDK4 selumetinib 0.3739875 0.8935947 0.37399 NA NA
MET nilotinib 0.3749787 0.8935947 0.37498 NA NA
RET erlotinib 0.3769409 0.8935947 0.37694 NA NA
EGFR erlotinib 0.3780620 0.8935947 0.37806 NA NA
BTK lapatinib 0.3783216 0.8935947 0.37832 NA NA
CD79B selumetinib 0.3789936 0.8935947 0.37899 NA NA
SF3B1 selumetinib 0.3794567 0.8935947 0.37946 NA NA
SRSF2 nilotinib 0.3795016 0.8935947 0.37950 NA NA
MAP2K1 lapatinib 0.3798461 0.8935947 0.37985 NA NA
AKT3 erlotinib 0.3831353 0.8981021 0.38314 NA NA
CTNNB1 erlotinib 0.3868718 0.9016265 0.38687 NA NA
SMC1A selumetinib 0.3873961 0.9016265 0.38740 NA NA
AKT3 lapatinib 0.3897579 0.9017376 0.38976 NA NA
NRAS irinotecan 0.3909888 0.9017376 0.39099 NA NA
KIT erlotinib 0.3945572 0.9017376 0.39456 NA NA
PAX5 nilotinib 0.3950175 0.9017376 0.39502 NA NA
NCOA2 erlotinib 0.3950763 0.9017376 0.39508 NA NA
CBLB selumetinib 0.3957166 0.9017376 0.39572 NA NA
NOTCH1 erlotinib 0.4015628 0.9118822 0.40156 NA NA
NPM1 erlotinib 0.4081068 0.9202658 0.40811 NA NA
AKT1 erlotinib 0.4089836 0.9202658 0.40898 NA NA
GNAQ nilotinib 0.4094761 0.9202658 0.40948 NA NA
TSC2 erlotinib 0.4143017 0.9253688 0.41430 NA NA
ALK irinotecan 0.4159284 0.9253688 0.41593 NA NA
MAP2K1 irinotecan 0.4180667 0.9253688 0.41807 NA NA
HRAS erlotinib 0.4181676 0.9253688 0.41817 NA NA
CDK6 selumetinib 0.4197911 0.9253688 0.41979 NA NA
RAD21 selumetinib 0.4202363 0.9253688 0.42024 NA NA
HRAS lapatinib 0.4223510 0.9269045 0.42235 NA NA
VHL irinotecan 0.4240695 0.9275634 0.42407 NA NA
MPL lapatinib 0.4272603 0.9283631 0.42726 NA NA
WHSC1 lapatinib 0.4278387 0.9283631 0.42784 NA NA
KIT selumetinib 0.4291048 0.9283631 0.42910 NA NA
SETBP1 erlotinib 0.4301182 0.9283631 0.43012 NA NA
PIK3CA lapatinib 0.4324195 0.9283631 0.43242 NA NA
BRCA2 nilotinib 0.4329522 0.9283631 0.43295 NA NA
SETBP1 selumetinib 0.4352803 0.9303049 0.43528 NA NA
GNB1 selumetinib 0.4390316 0.9320078 0.43903 NA NA
DNMT3A nilotinib 0.4393202 0.9320078 0.43932 NA NA
FBXW7 selumetinib 0.4403523 0.9320078 0.44035 NA NA
ABL1 lapatinib 0.4453225 0.9370319 0.44532 NA NA
RAD21 nilotinib 0.4455916 0.9370319 0.44559 NA NA
BTK irinotecan 0.4499106 0.9419721 0.44991 NA NA
SMC3 erlotinib 0.4530753 0.9419721 0.45308 NA NA
FLT3 erlotinib 0.4536996 0.9419721 0.45370 NA NA
MPL nilotinib 0.4540395 0.9419721 0.45404 NA NA
ESR1 selumetinib 0.4556101 0.9419721 0.45561 NA NA
GNB1 lapatinib 0.4579231 0.9419721 0.45792 NA NA
MYD88 lapatinib 0.4587151 0.9419721 0.45872 NA NA
CD274 irinotecan 0.4598390 0.9419721 0.45984 NA NA
ALK lapatinib 0.4609038 0.9419721 0.46090 NA NA
SRSF2 erlotinib 0.4661229 0.9424744 0.46612 NA NA
CD274 selumetinib 0.4672104 0.9424744 0.46721 NA NA
MDM2 erlotinib 0.4709707 0.9424744 0.47097 NA NA
CTLA4 selumetinib 0.4717193 0.9424744 0.47172 NA NA
DNAJB1 irinotecan 0.4725298 0.9424744 0.47253 NA NA
STAT3 selumetinib 0.4741982 0.9424744 0.47420 NA NA
CRLF2 selumetinib 0.4762722 0.9424744 0.47627 NA NA
PAX8 lapatinib 0.4777998 0.9424744 0.47780 NA NA
SMC3 irinotecan 0.4778543 0.9424744 0.47785 NA NA
FBXW7 erlotinib 0.4790992 0.9424744 0.47910 NA NA
DDIT3 erlotinib 0.4794295 0.9424744 0.47943 NA NA
PDGFRB nilotinib 0.4795241 0.9424744 0.47952 NA NA
PHF6 irinotecan 0.4809070 0.9424744 0.48091 NA NA
BCORL1 erlotinib 0.4833897 0.9424744 0.48339 NA NA
ROS1 irinotecan 0.4834670 0.9424744 0.48347 NA NA
TPMT erlotinib 0.4842070 0.9424744 0.48421 NA NA
GNA11 lapatinib 0.4911808 0.9517886 0.49118 NA NA
HRAS selumetinib 0.4931995 0.9517886 0.49320 NA NA
CD79B erlotinib 0.4933583 0.9517886 0.49336 NA NA
DPYD lapatinib 0.4951753 0.9524843 0.49518 NA NA
NT5C2 nilotinib 0.4985874 0.9562351 0.49859 NA NA
FGFR3 erlotinib 0.5057821 0.9671974 0.50578 NA NA
NOTCH1 irinotecan 0.5083990 0.9693671 0.50840 NA NA
PDGFB irinotecan 0.5117862 0.9696657 0.51179 NA NA
TET2 irinotecan 0.5145990 0.9696657 0.51460 NA NA
PTPN11 irinotecan 0.5165017 0.9696657 0.51650 NA NA
CTCF lapatinib 0.5174017 0.9696657 0.51740 NA NA
IDH1 irinotecan 0.5177897 0.9696657 0.51779 NA NA
ESR1 nilotinib 0.5209092 0.9696657 0.52091 NA NA
NPM1 nilotinib 0.5225901 0.9696657 0.52259 NA NA
ETV6 nilotinib 0.5231112 0.9696657 0.52311 NA NA
VHL nilotinib 0.5249231 0.9696657 0.52492 NA NA
EML4 selumetinib 0.5261206 0.9696657 0.52612 NA NA
MAP2K1 erlotinib 0.5270899 0.9696657 0.52709 NA NA
TP53 nilotinib 0.5288472 0.9696657 0.52885 NA NA
CDKN2A nilotinib 0.5300461 0.9696657 0.53005 NA NA
PRPF40B nilotinib 0.5310239 0.9696657 0.53102 NA NA
AKT2 selumetinib 0.5332426 0.9696657 0.53324 NA NA
BRCA1 lapatinib 0.5346294 0.9696657 0.53463 NA NA
IDH2 irinotecan 0.5383687 0.9696657 0.53837 NA NA
GATA3 lapatinib 0.5384377 0.9696657 0.53844 NA NA
NOTCH2 nilotinib 0.5393383 0.9696657 0.53934 NA NA
IL7R lapatinib 0.5439112 0.9696657 0.54391 NA NA
ESR1 erlotinib 0.5463206 0.9696657 0.54632 NA NA
SRSF2 irinotecan 0.5486376 0.9696657 0.54864 NA NA
VHL erlotinib 0.5488405 0.9696657 0.54884 NA NA
IKZF1 lapatinib 0.5493652 0.9696657 0.54937 NA NA
FGFR3 selumetinib 0.5504813 0.9696657 0.55048 NA NA
FLCN erlotinib 0.5527653 0.9696657 0.55277 NA NA
ATM lapatinib 0.5550964 0.9696657 0.55510 NA NA
CREBBP selumetinib 0.5551165 0.9696657 0.55512 NA NA
PDCD1 nilotinib 0.5606283 0.9696657 0.56063 NA NA
KMT2A irinotecan 0.5662482 0.9696657 0.56625 NA NA
MET lapatinib 0.5678884 0.9696657 0.56789 NA NA
CEBPA irinotecan 0.5694611 0.9696657 0.56946 NA NA
SMO nilotinib 0.5711686 0.9696657 0.57117 NA NA
PTPN11 selumetinib 0.5722801 0.9696657 0.57228 NA NA
CYP19A1 erlotinib 0.5725012 0.9696657 0.57250 NA NA
EGF lapatinib 0.5756426 0.9696657 0.57564 NA NA
EGFR selumetinib 0.5763443 0.9696657 0.57634 NA NA
GATA2 lapatinib 0.5776923 0.9696657 0.57769 NA NA
JAK3 selumetinib 0.5791652 0.9696657 0.57917 NA NA
CALR selumetinib 0.5793494 0.9696657 0.57935 NA NA
CTNNB1 nilotinib 0.5810417 0.9696657 0.58104 NA NA
PIGA irinotecan 0.5810477 0.9696657 0.58105 NA NA
PDGFRB lapatinib 0.5810825 0.9696657 0.58108 NA NA
CTNNB1 lapatinib 0.5823848 0.9696657 0.58238 NA NA
CSF3R nilotinib 0.5848095 0.9696657 0.58481 NA NA
JAK1 lapatinib 0.5848719 0.9696657 0.58487 NA NA
MAP2K1 selumetinib 0.5850648 0.9696657 0.58506 NA NA
SSX1 nilotinib 0.5863196 0.9696657 0.58632 NA NA
PRPF40B erlotinib 0.5871846 0.9696657 0.58718 NA NA
IL7R erlotinib 0.5879645 0.9696657 0.58796 NA NA
UGT1A1 lapatinib 0.5880643 0.9696657 0.58806 NA NA
RIT1 lapatinib 0.5908467 0.9696657 0.59085 NA NA
FLT3 nilotinib 0.5913464 0.9696657 0.59135 NA NA
PDGFRA irinotecan 0.5925752 0.9696657 0.59258 NA NA
GNAS lapatinib 0.5958805 0.9696657 0.59588 NA NA
NT5C2 irinotecan 0.5962588 0.9696657 0.59626 NA NA
RET nilotinib 0.5975829 0.9696657 0.59758 NA NA
CDK4 lapatinib 0.5976694 0.9696657 0.59767 NA NA
NRAS nilotinib 0.5977193 0.9696657 0.59772 NA NA
JAK3 irinotecan 0.5999452 0.9696657 0.59995 NA NA
TSC1 irinotecan 0.6014923 0.9696657 0.60149 NA NA
SETD2 lapatinib 0.6015271 0.9696657 0.60153 NA NA
AKT1 lapatinib 0.6019637 0.9696657 0.60196 NA NA
CBL nilotinib 0.6047466 0.9699710 0.60475 NA NA
PTPN11 nilotinib 0.6063462 0.9699710 0.60635 NA NA
CBL erlotinib 0.6066026 0.9699710 0.60660 NA NA
SF1 nilotinib 0.6086888 0.9709328 0.60869 NA NA
TSC2 selumetinib 0.6111574 0.9724987 0.61116 NA NA
CDKN2A lapatinib 0.6158264 0.9765194 0.61583 NA NA
RUNX1 lapatinib 0.6166705 0.9765194 0.61667 NA NA
JAK3 lapatinib 0.6237232 0.9842813 0.62372 NA NA
ERBB2 irinotecan 0.6286426 0.9842813 0.62864 NA NA
PML irinotecan 0.6294330 0.9842813 0.62943 NA NA
FANCL irinotecan 0.6327514 0.9842813 0.63275 NA NA
G6PD lapatinib 0.6332410 0.9842813 0.63324 NA NA
CXCR4 irinotecan 0.6348669 0.9842813 0.63487 NA NA
ATM selumetinib 0.6349288 0.9842813 0.63493 NA NA
SETBP1 lapatinib 0.6353669 0.9842813 0.63537 NA NA
RET irinotecan 0.6389716 0.9842813 0.63897 NA NA
CTCF nilotinib 0.6405142 0.9842813 0.64051 NA NA
TSC1 erlotinib 0.6505989 0.9842813 0.65060 NA NA
AKT3 irinotecan 0.6506008 0.9842813 0.65060 NA NA
CDC73 selumetinib 0.6511899 0.9842813 0.65119 NA NA
SMC1A lapatinib 0.6516111 0.9842813 0.65161 NA NA
CBL lapatinib 0.6524341 0.9842813 0.65243 NA NA
MET selumetinib 0.6524774 0.9842813 0.65248 NA NA
WHSC1 irinotecan 0.6542440 0.9842813 0.65424 NA NA
PDCD1 irinotecan 0.6545590 0.9842813 0.65456 NA NA
U2AF1 selumetinib 0.6577081 0.9842813 0.65771 NA NA
GATA1 erlotinib 0.6580401 0.9842813 0.65804 NA NA
KIT nilotinib 0.6606331 0.9842813 0.66063 NA NA
IKZF1 selumetinib 0.6611150 0.9842813 0.66111 NA NA
ABL1 selumetinib 0.6628862 0.9842813 0.66289 NA NA
PDGFRB selumetinib 0.6645199 0.9842813 0.66452 NA NA
ABL1 irinotecan 0.6660281 0.9842813 0.66603 NA NA
TPMT nilotinib 0.6679929 0.9842813 0.66799 NA NA
JAK1 nilotinib 0.6683405 0.9842813 0.66834 NA NA
GNB1 erlotinib 0.6685175 0.9842813 0.66852 NA NA
PRPF40B selumetinib 0.6689523 0.9842813 0.66895 NA NA
CTNNB1 irinotecan 0.6690072 0.9842813 0.66901 NA NA
AR lapatinib 0.6705630 0.9842813 0.67056 NA NA
MDM2 selumetinib 0.6727814 0.9842813 0.67278 NA NA
EZH2 irinotecan 0.6733468 0.9842813 0.67335 NA NA
CTNNB1 selumetinib 0.6746071 0.9842813 0.67461 NA NA
AKT3 nilotinib 0.6789529 0.9842813 0.67895 NA NA
FGFR1 nilotinib 0.6796758 0.9842813 0.67968 NA NA
EED selumetinib 0.6798049 0.9842813 0.67980 NA NA
FLCN selumetinib 0.6802253 0.9842813 0.68023 NA NA
EGF selumetinib 0.6802678 0.9842813 0.68027 NA NA
ROS1 nilotinib 0.6819122 0.9844825 0.68191 NA NA
DPYD erlotinib 0.6840148 0.9853430 0.68401 NA NA
DPYD selumetinib 0.6868738 0.9857566 0.68687 NA NA
BTK erlotinib 0.6873166 0.9857566 0.68732 NA NA
PIGA lapatinib 0.6899301 0.9861415 0.68993 NA NA
MYD88 nilotinib 0.6912056 0.9861415 0.69121 NA NA
TSC2 nilotinib 0.6921085 0.9861415 0.69211 NA NA
CYP19A1 lapatinib 0.6950890 0.9882352 0.69509 NA NA
IKZF1 erlotinib 0.7003041 0.9917784 0.70030 NA NA
PRPF8 irinotecan 0.7015023 0.9917784 0.70150 NA NA
NRAS erlotinib 0.7042626 0.9917784 0.70426 NA NA
RIT1 erlotinib 0.7055740 0.9917784 0.70557 NA NA
WHSC1 erlotinib 0.7063712 0.9917784 0.70637 NA NA
PTPN11 erlotinib 0.7104107 0.9917784 0.71041 NA NA
ZRSR2 lapatinib 0.7127565 0.9917784 0.71276 NA NA
PTCH1 irinotecan 0.7162618 0.9917784 0.71626 NA NA
SF3B1 irinotecan 0.7173061 0.9917784 0.71731 NA NA
PDCD1 selumetinib 0.7186602 0.9917784 0.71866 NA NA
NOTCH2 selumetinib 0.7202092 0.9917784 0.72021 NA NA
SSX1 erlotinib 0.7213924 0.9917784 0.72139 NA NA
SH2B3 lapatinib 0.7233868 0.9917784 0.72339 NA NA
DDIT3 selumetinib 0.7243926 0.9917784 0.72439 NA NA
MYD88 selumetinib 0.7246756 0.9917784 0.72468 NA NA
ATM erlotinib 0.7248163 0.9917784 0.72482 NA NA
JAK3 erlotinib 0.7290446 0.9917784 0.72904 NA NA
PTCH1 erlotinib 0.7302464 0.9917784 0.73025 NA NA
BTK nilotinib 0.7312736 0.9917784 0.73127 NA NA
BCORL1 selumetinib 0.7333376 0.9917784 0.73334 NA NA
CBLB irinotecan 0.7342163 0.9917784 0.73422 NA NA
EZH2 erlotinib 0.7344706 0.9917784 0.73447 NA NA
TSC1 lapatinib 0.7401698 0.9917784 0.74017 NA NA
RUNX1 erlotinib 0.7408697 0.9917784 0.74087 NA NA
PIGA selumetinib 0.7421261 0.9917784 0.74213 NA NA
JAK1 erlotinib 0.7446534 0.9917784 0.74465 NA NA
TET2 nilotinib 0.7479864 0.9917784 0.74799 NA NA
FGFR3 nilotinib 0.7486898 0.9917784 0.74869 NA NA
GATA1 irinotecan 0.7510689 0.9917784 0.75107 NA NA
PRPF40B lapatinib 0.7523713 0.9917784 0.75237 NA NA
FLCN nilotinib 0.7541296 0.9917784 0.75413 NA NA
RPL10 irinotecan 0.7548056 0.9917784 0.75481 NA NA
SETD2 nilotinib 0.7552064 0.9917784 0.75521 NA NA
GNA11 selumetinib 0.7569104 0.9917784 0.75691 NA NA
CDC73 lapatinib 0.7574639 0.9917784 0.75746 NA NA
SMC1A irinotecan 0.7580493 0.9917784 0.75805 NA NA
NCOA2 selumetinib 0.7585886 0.9917784 0.75859 NA NA
FGFR3 irinotecan 0.7590167 0.9917784 0.75902 NA NA
CREBBP nilotinib 0.7621143 0.9917784 0.76211 NA NA
PDGFB selumetinib 0.7634636 0.9917784 0.76346 NA NA
CRLF2 irinotecan 0.7651322 0.9917784 0.76513 NA NA
FGFR3 lapatinib 0.7703491 0.9917784 0.77035 NA NA
MAP2K2 lapatinib 0.7714479 0.9917784 0.77145 NA NA
SSX1 irinotecan 0.7716424 0.9917784 0.77164 NA NA
ERBB4 erlotinib 0.7781237 0.9917784 0.77812 NA NA
G6PD erlotinib 0.7787902 0.9917784 0.77879 NA NA
CTLA4 nilotinib 0.7791419 0.9917784 0.77914 NA NA
FGFR1 erlotinib 0.7800078 0.9917784 0.78001 NA NA
HRAS irinotecan 0.7830688 0.9917784 0.78307 NA NA
AR selumetinib 0.7836835 0.9917784 0.78368 NA NA
SMC3 lapatinib 0.7862153 0.9917784 0.78622 NA NA
PTCH1 lapatinib 0.7871784 0.9917784 0.78718 NA NA
KMT2A erlotinib 0.7907716 0.9917784 0.79077 NA NA
PHF6 selumetinib 0.7908963 0.9917784 0.79090 NA NA
EGFR lapatinib 0.7947247 0.9917784 0.79472 NA NA
BCOR nilotinib 0.7961781 0.9917784 0.79618 NA NA
GNAS erlotinib 0.7962137 0.9917784 0.79621 NA NA
PAX8 erlotinib 0.7962376 0.9917784 0.79624 NA NA
RUNX1 irinotecan 0.7975944 0.9917784 0.79759 NA NA
GATA3 nilotinib 0.7977219 0.9917784 0.79772 NA NA
SMC1A nilotinib 0.7980647 0.9917784 0.79806 NA NA
ALK nilotinib 0.7983903 0.9917784 0.79839 NA NA
SSX1 selumetinib 0.7987359 0.9917784 0.79874 NA NA
SMO irinotecan 0.7988480 0.9917784 0.79885 NA NA
TSC1 nilotinib 0.7988924 0.9917784 0.79889 NA NA
ERBB4 lapatinib 0.8042029 0.9917784 0.80420 NA NA
GATA2 nilotinib 0.8059928 0.9917784 0.80599 NA NA
AKT2 irinotecan 0.8069935 0.9917784 0.80699 NA NA
RUNX1 nilotinib 0.8073074 0.9917784 0.80731 NA NA
WT1 selumetinib 0.8117996 0.9917784 0.81180 NA NA
AR nilotinib 0.8128485 0.9917784 0.81285 NA NA
MPL erlotinib 0.8134653 0.9917784 0.81347 NA NA
IDH2 lapatinib 0.8145125 0.9917784 0.81451 NA NA
SSX1 lapatinib 0.8176005 0.9917784 0.81760 NA NA
DNAJB1 selumetinib 0.8178008 0.9917784 0.81780 NA NA
CSF3R irinotecan 0.8191014 0.9917784 0.81910 NA NA
XPO1 irinotecan 0.8196641 0.9917784 0.81966 NA NA
BRCA1 irinotecan 0.8210965 0.9917784 0.82110 NA NA
CD79B lapatinib 0.8217468 0.9917784 0.82175 NA NA
ERBB2 selumetinib 0.8218228 0.9917784 0.82182 NA NA
UGT1A1 erlotinib 0.8238031 0.9917784 0.82380 NA NA
G6PD irinotecan 0.8254252 0.9917784 0.82543 NA NA
ROS1 selumetinib 0.8271911 0.9917784 0.82719 NA NA
ALK selumetinib 0.8278795 0.9917784 0.82788 NA NA
PDGFRB erlotinib 0.8279937 0.9917784 0.82799 NA NA
MGMT nilotinib 0.8301945 0.9917784 0.83019 NA NA
UGT1A1 irinotecan 0.8309879 0.9917784 0.83099 NA NA
FANCL erlotinib 0.8310314 0.9917784 0.83103 NA NA
DDIT3 lapatinib 0.8377397 0.9959455 0.83774 NA NA
FGFR1 selumetinib 0.8422202 0.9959455 0.84222 NA NA
NT5C2 erlotinib 0.8425719 0.9959455 0.84257 NA NA
ERBB4 selumetinib 0.8446106 0.9959455 0.84461 NA NA
MYCN nilotinib 0.8448350 0.9959455 0.84483 NA NA
KMT2A lapatinib 0.8454470 0.9959455 0.84545 NA NA
NCOA2 irinotecan 0.8517003 0.9959455 0.85170 NA NA
ABL1 erlotinib 0.8522490 0.9959455 0.85225 NA NA
IL7R nilotinib 0.8524502 0.9959455 0.85245 NA NA
FLT3 selumetinib 0.8527746 0.9959455 0.85277 NA NA
TET2 erlotinib 0.8613977 0.9959455 0.86140 NA NA
FLT3 lapatinib 0.8614733 0.9959455 0.86147 NA NA
PDGFRA nilotinib 0.8621321 0.9959455 0.86213 NA NA
SETD2 selumetinib 0.8627670 0.9959455 0.86277 NA NA
BCOR lapatinib 0.8638970 0.9959455 0.86390 NA NA
RPL10 selumetinib 0.8658058 0.9959455 0.86581 NA NA
ERBB3 selumetinib 0.8669447 0.9959455 0.86694 NA NA
CTCF selumetinib 0.8706349 0.9959455 0.87063 NA NA
CXCR4 nilotinib 0.8733725 0.9959455 0.87337 NA NA
CDKN2A erlotinib 0.8747139 0.9959455 0.87471 NA NA
EZH2 nilotinib 0.8752021 0.9959455 0.87520 NA NA
NT5C2 lapatinib 0.8753678 0.9959455 0.87537 NA NA
STAG2 nilotinib 0.8759840 0.9959455 0.87598 NA NA
BCORL1 lapatinib 0.8806185 0.9959455 0.88062 NA NA
NPM1 selumetinib 0.8832243 0.9959455 0.88322 NA NA
STAG2 lapatinib 0.8834116 0.9959455 0.88341 NA NA
STAT3 erlotinib 0.8844399 0.9959455 0.88444 NA NA
KIT irinotecan 0.8862231 0.9959455 0.88622 NA NA
FGFR1 irinotecan 0.8871126 0.9959455 0.88711 NA NA
MYD88 erlotinib 0.8885739 0.9959455 0.88857 NA NA
MDM2 nilotinib 0.8889052 0.9959455 0.88891 NA NA
PRPF8 lapatinib 0.8893234 0.9959455 0.88932 NA NA
RIT1 nilotinib 0.8908541 0.9959455 0.89085 NA NA
UGT1A1 selumetinib 0.8917738 0.9959455 0.89177 NA NA
NPM1 irinotecan 0.8930026 0.9959455 0.89300 NA NA
NOTCH1 nilotinib 0.8983617 0.9959455 0.89836 NA NA
DNMT3A erlotinib 0.9005581 0.9959455 0.90056 NA NA
CBL irinotecan 0.9079854 0.9959455 0.90799 NA NA
KMT2A nilotinib 0.9084944 0.9959455 0.90849 NA NA
ASXL1 irinotecan 0.9089550 0.9959455 0.90895 NA NA
TPMT lapatinib 0.9089736 0.9959455 0.90897 NA NA
CDK6 lapatinib 0.9113470 0.9959455 0.91135 NA NA
GATA3 erlotinib 0.9119616 0.9959455 0.91196 NA NA
PML nilotinib 0.9170484 0.9959455 0.91705 NA NA
PAX5 lapatinib 0.9176528 0.9959455 0.91765 NA NA
AKT2 lapatinib 0.9180125 0.9959455 0.91801 NA NA
AKT1 selumetinib 0.9187209 0.9959455 0.91872 NA NA
PAX5 selumetinib 0.9213643 0.9959455 0.92136 NA NA
U2AF1 nilotinib 0.9215704 0.9959455 0.92157 NA NA
FLCN irinotecan 0.9219343 0.9959455 0.92193 NA NA
HRAS nilotinib 0.9225162 0.9959455 0.92252 NA NA
MGMT selumetinib 0.9254057 0.9959455 0.92541 NA NA
CTCF irinotecan 0.9262120 0.9959455 0.92621 NA NA
IL7R selumetinib 0.9287200 0.9959455 0.92872 NA NA
EGF irinotecan 0.9294390 0.9959455 0.92944 NA NA
AKT2 nilotinib 0.9311619 0.9959455 0.93116 NA NA
CXCR4 selumetinib 0.9335671 0.9959455 0.93357 NA NA
CDK6 irinotecan 0.9369407 0.9959455 0.93694 NA NA
BCOR irinotecan 0.9384232 0.9959455 0.93842 NA NA
SF1 selumetinib 0.9388121 0.9959455 0.93881 NA NA
TET2 selumetinib 0.9390759 0.9959455 0.93908 NA NA
PTEN irinotecan 0.9404034 0.9959455 0.94040 NA NA
SH2B3 irinotecan 0.9413890 0.9959455 0.94139 NA NA
MPL irinotecan 0.9419762 0.9959455 0.94198 NA NA
MDM2 irinotecan 0.9444299 0.9959455 0.94443 NA NA
SH2B3 selumetinib 0.9448071 0.9959455 0.94481 NA NA
PHF6 lapatinib 0.9451994 0.9959455 0.94520 NA NA
WT1 irinotecan 0.9470140 0.9959455 0.94701 NA NA
FGFR2 nilotinib 0.9470949 0.9959455 0.94709 NA NA
MAP2K2 irinotecan 0.9474730 0.9959455 0.94747 NA NA
ALK erlotinib 0.9492432 0.9959455 0.94924 NA NA
PML selumetinib 0.9504098 0.9959455 0.95041 NA NA
BRCA1 nilotinib 0.9506540 0.9959455 0.95065 NA NA
PTEN lapatinib 0.9516739 0.9959455 0.95167 NA NA
PTCH1 nilotinib 0.9525059 0.9959455 0.95251 NA NA
EGFR nilotinib 0.9540597 0.9959455 0.95406 NA NA
BRCA1 selumetinib 0.9592240 0.9959455 0.95922 NA NA
AKT2 erlotinib 0.9628110 0.9959455 0.96281 NA NA
ESR1 lapatinib 0.9641363 0.9959455 0.96414 NA NA
XPO1 selumetinib 0.9668163 0.9959455 0.96682 NA NA
CXCR4 lapatinib 0.9673812 0.9959455 0.96738 NA NA
BCORL1 irinotecan 0.9680876 0.9959455 0.96809 NA NA
ERBB3 irinotecan 0.9705439 0.9959455 0.97054 NA NA
PTPN11 lapatinib 0.9711271 0.9959455 0.97113 NA NA
CDKN2A irinotecan 0.9752204 0.9959455 0.97522 NA NA
GNAQ selumetinib 0.9752766 0.9959455 0.97528 NA NA
CDK6 erlotinib 0.9761607 0.9959455 0.97616 NA NA
PAX5 erlotinib 0.9776368 0.9959455 0.97764 NA NA
SETD2 erlotinib 0.9776368 0.9959455 0.97764 NA NA
SF3B1 erlotinib 0.9789551 0.9959455 0.97896 NA NA
TP53 erlotinib 0.9801201 0.9959455 0.98012 NA NA
GNAS nilotinib 0.9824645 0.9959455 0.98246 NA NA
RPL10 erlotinib 0.9825514 0.9959455 0.98255 NA NA
SF3B1 nilotinib 0.9834968 0.9959455 0.98350 NA NA
FGFR2 lapatinib 0.9842030 0.9959455 0.98420 NA NA
BCOR erlotinib 0.9848467 0.9959455 0.98485 NA NA
TPMT selumetinib 0.9863877 0.9959455 0.98639 NA NA
SF3B1 lapatinib 0.9865575 0.9959455 0.98656 NA NA
MYCN selumetinib 0.9888743 0.9959455 0.98887 NA NA
CSF3R lapatinib 0.9895734 0.9959455 0.98957 NA NA
PRPF8 erlotinib 0.9895951 0.9959455 0.98960 NA NA
SH2B3 erlotinib 0.9898541 0.9959455 0.98985 NA NA
MYCN irinotecan 0.9924251 0.9969985 0.99243 NA NA
WT1 nilotinib 0.9955641 0.9972248 0.99556 NA NA
BCORL1 nilotinib 0.9957000 0.9972248 0.99570 NA NA
ABL1 nilotinib 0.9989982 0.9989982 0.99900 NA NA 
ccle_signif_lvlA_ByDrug <- readRDS("./data_munging/rds/ccle_signif_lvlA_ByDrug.rds")
ccle_signif_lvlA_ByDrug_all <- rbindlist(ccle_signif_lvlA_ByDrug, use.names = TRUE)
ccle_signif_lvlA_ByDrug_all <- ccle_signif_lvlA_ByDrug_all[order(ccle_signif_lvlA_ByDrug_all$p.adj),]

knitr::kable(ccle_signif_lvlA_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: by-drug Wilcoxon test results for Level A point mutations, (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CCLE: by-drug Wilcoxon test results for Level A point mutations, (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
BRAF selumetinib 0.0000000 0.0000063 4.8e-08 **** ****
NRAS selumetinib 0.0000274 0.0017948 2.7e-05 **** **
KRAS selumetinib 0.0004853 0.0211935 0.00049 ***
ETV6 selumetinib 0.0021320 0.0698235 0.00213 ** NA
CDKN2A selumetinib 0.0042499 0.1113468 0.00425 ** NA
PRPF8 selumetinib 0.0099673 0.2086951 0.00997 ** NA
ASXL1 selumetinib 0.0111516 0.2086951 0.01115
NA
MPL selumetinib 0.0172826 0.2830021 0.01728
NA
JAK1 irinotecan 0.0074451 0.4331076 0.0074 ** NA
FBXW7 irinotecan 0.0090628 0.4331076 0.0091 ** NA
KRAS irinotecan 0.0107870 0.4331076 0.0108
NA
FLT3 irinotecan 0.0133264 0.4331076 0.0133
NA
SETD2 irinotecan 0.0181928 0.4730131 0.0182
NA
RUNX1 selumetinib 0.0372876 0.5427417 0.03729
NA
WHSC1 selumetinib 0.0603852 0.7275248 0.06039 NA NA
PTEN selumetinib 0.0676687 0.7275248 0.06767 NA NA
SMO selumetinib 0.0780507 0.7275248 0.07805 NA NA
IDH1 selumetinib 0.0795440 0.7275248 0.07954 NA NA
BRCA2 selumetinib 0.0801455 0.7275248 0.08015 NA NA
G6PD selumetinib 0.0848649 0.7275248 0.08486 NA NA
IDH2 selumetinib 0.0923191 0.7275248 0.09232 NA NA
AKT3 selumetinib 0.1094130 0.7275248 0.10941 NA NA
EZH2 selumetinib 0.1105216 0.7275248 0.11052 NA NA
PTCH1 selumetinib 0.1105610 0.7275248 0.11056 NA NA
BCOR selumetinib 0.1155220 0.7275248 0.11552 NA NA
GNAS selumetinib 0.1198231 0.7275248 0.11982 NA NA
PDGFRA selumetinib 0.1271928 0.7275248 0.12719 NA NA
ZRSR2 selumetinib 0.1277334 0.7275248 0.12773 NA NA
BRAF erlotinib 0.0224018 0.7416038 0.022
NA
CD274 erlotinib 0.0296833 0.7416038 0.030
NA
ERBB2 erlotinib 0.0361008 0.7416038 0.036
NA
PDGFB erlotinib 0.0406263 0.7416038 0.041
NA
NOTCH2 erlotinib 0.0501837 0.7416038 0.050 NA NA
MYCN erlotinib 0.0511362 0.7416038 0.051 NA NA
CRLF2 erlotinib 0.0586240 0.7416038 0.059 NA NA
DNAJB1 erlotinib 0.0624342 0.7416038 0.062 NA NA
IDH1 erlotinib 0.0637744 0.7416038 0.064 NA NA
PIGA erlotinib 0.0708932 0.7416038 0.071 NA NA
CALR erlotinib 0.0711196 0.7416038 0.071 NA NA
CXCR4 erlotinib 0.0741100 0.7416038 0.074 NA NA
ROS1 erlotinib 0.0964090 0.7416038 0.096 NA NA
STAG2 erlotinib 0.1047686 0.7416038 0.105 NA NA
U2AF1 erlotinib 0.1205628 0.7416038 0.121 NA NA
CTLA4 erlotinib 0.1220555 0.7416038 0.122 NA NA
EML4 erlotinib 0.1250336 0.7416038 0.125 NA NA
MAP2K2 erlotinib 0.1309379 0.7416038 0.131 NA NA
SMC1A erlotinib 0.1324733 0.7416038 0.132 NA NA
PHF6 erlotinib 0.1395872 0.7416038 0.140 NA NA
GATA2 erlotinib 0.1428705 0.7416038 0.143 NA NA
SMO erlotinib 0.1461317 0.7416038 0.146 NA NA
AR erlotinib 0.1463011 0.7416038 0.146 NA NA
PDGFRA erlotinib 0.1494369 0.7416038 0.149 NA NA
ERBB3 erlotinib 0.1517945 0.7416038 0.152 NA NA
WT1 erlotinib 0.1553226 0.7416038 0.155 NA NA
MGMT erlotinib 0.1554862 0.7416038 0.155 NA NA
CBLB erlotinib 0.1604334 0.7416038 0.160 NA NA
MET erlotinib 0.1724618 0.7416038 0.172 NA NA
SF1 erlotinib 0.1731756 0.7416038 0.173 NA NA
ASXL1 erlotinib 0.1754940 0.7416038 0.175 NA NA
KMT2A selumetinib 0.1379561 0.7530106 0.13796 NA NA
DNMT3A selumetinib 0.1475871 0.7594468 0.14759 NA NA
CSF3R selumetinib 0.1508988 0.7594468 0.15090 NA NA
STAG2 selumetinib 0.1648011 0.7594468 0.16480 NA NA
JAK2 selumetinib 0.1725059 0.7594468 0.17251 NA NA
JAK1 selumetinib 0.1737020 0.7594468 0.17370 NA NA
PIK3CA selumetinib 0.1739191 0.7594468 0.17392 NA NA
XPO1 erlotinib 0.1879584 0.7617063 0.188 NA NA
CSF3R erlotinib 0.2026368 0.7617063 0.203 NA NA
JAK2 erlotinib 0.2076226 0.7617063 0.208 NA NA
IDH2 erlotinib 0.2087321 0.7617063 0.209 NA NA
CTCF erlotinib 0.2093239 0.7617063 0.209 NA NA
ZRSR2 irinotecan 0.0372753 0.7895340 0.0373
NA
TSC2 irinotecan 0.0425134 0.7895340 0.0425
NA
PTEN erlotinib 0.2232818 0.7905384 0.223 NA NA
DDIT3 irinotecan 0.0544500 0.7998163 0.0545 NA NA
EED irinotecan 0.0574304 0.7998163 0.0574 NA NA
NOTCH2 irinotecan 0.0615243 0.7998163 0.0615 NA NA
ERBB3 lapatinib 0.0129696 0.8008651 0.013
NA
ASXL1 lapatinib 0.0139893 0.8008651 0.014
NA
KIT lapatinib 0.0299886 0.8008651 0.030
NA
XPO1 lapatinib 0.0354732 0.8008651 0.035
NA
WT1 lapatinib 0.0500201 0.8008651 0.050 NA NA
ERBB2 lapatinib 0.0500292 0.8008651 0.050 NA NA
CD274 lapatinib 0.0504368 0.8008651 0.050 NA NA
ROS1 lapatinib 0.0638294 0.8008651 0.064 NA NA
CEBPA lapatinib 0.0701353 0.8008651 0.070 NA NA
MGMT lapatinib 0.0716529 0.8008651 0.072 NA NA
CRLF2 lapatinib 0.0760006 0.8008651 0.076 NA NA
RAD21 lapatinib 0.0773127 0.8008651 0.077 NA NA
DNMT3A lapatinib 0.0910216 0.8008651 0.091 NA NA
CBLB lapatinib 0.1059300 0.8008651 0.106 NA NA
SRSF2 lapatinib 0.1089131 0.8008651 0.109 NA NA
TET2 lapatinib 0.1133220 0.8008651 0.113 NA NA
DNAJB1 lapatinib 0.1176422 0.8008651 0.118 NA NA
NOTCH1 lapatinib 0.1297020 0.8008651 0.130 NA NA
TSC2 lapatinib 0.1353477 0.8008651 0.135 NA NA
BRCA2 lapatinib 0.1454060 0.8008651 0.145 NA NA
CALR lapatinib 0.1520641 0.8008651 0.152 NA NA
PDGFRA lapatinib 0.1524894 0.8008651 0.152 NA NA
BRAF lapatinib 0.1535431 0.8008651 0.154 NA NA
FANCL lapatinib 0.1575032 0.8008651 0.158 NA NA
RET lapatinib 0.1587070 0.8008651 0.159 NA NA
SF1 lapatinib 0.1589503 0.8008651 0.159 NA NA
SRSF2 selumetinib 0.1939112 0.8194311 0.19391 NA NA
CTLA4 lapatinib 0.1692151 0.8210066 0.169 NA NA
PDGFB lapatinib 0.1902003 0.8215129 0.190 NA NA
TP53 lapatinib 0.1940528 0.8215129 0.194 NA NA
FBXW7 lapatinib 0.2051047 0.8215129 0.205 NA NA
GNAQ lapatinib 0.2084358 0.8215129 0.208 NA NA
MYCN lapatinib 0.2118132 0.8215129 0.212 NA NA
CREBBP lapatinib 0.2121723 0.8215129 0.212 NA NA
ETV6 lapatinib 0.2197037 0.8215129 0.220 NA NA
PDCD1 lapatinib 0.2263464 0.8215129 0.226 NA NA
MDM2 lapatinib 0.2279558 0.8215129 0.228 NA NA
U2AF1 lapatinib 0.2430493 0.8215129 0.243 NA NA
JAK2 lapatinib 0.2481605 0.8215129 0.248 NA NA
NRAS lapatinib 0.2515364 0.8215129 0.252 NA NA
EED lapatinib 0.2560293 0.8215129 0.256 NA NA
NPM1 lapatinib 0.2652151 0.8215129 0.265 NA NA
PML lapatinib 0.2673135 0.8215129 0.267 NA NA
VHL lapatinib 0.2715493 0.8215129 0.272 NA NA
NOTCH2 lapatinib 0.2759280 0.8215129 0.276 NA NA
FGFR2 erlotinib 0.2494792 0.8299993 0.249 NA NA
CREBBP erlotinib 0.2568307 0.8299993 0.257 NA NA
ZRSR2 erlotinib 0.2598896 0.8299993 0.260 NA NA
CEBPA erlotinib 0.2814510 0.8299993 0.281 NA NA
GNAQ erlotinib 0.2841793 0.8299993 0.284 NA NA
EGF erlotinib 0.2884798 0.8299993 0.288 NA NA
RAD21 erlotinib 0.2894193 0.8299993 0.289 NA NA
BRCA2 erlotinib 0.2904280 0.8299993 0.290 NA NA
CDK4 erlotinib 0.3023854 0.8299993 0.302 NA NA
PML erlotinib 0.3071538 0.8299993 0.307 NA NA
PDCD1 erlotinib 0.3307646 0.8299993 0.331 NA NA
CDC73 erlotinib 0.3331184 0.8299993 0.333 NA NA
GNA11 erlotinib 0.3332076 0.8299993 0.333 NA NA
EED erlotinib 0.3343486 0.8299993 0.334 NA NA
KRAS erlotinib 0.3430622 0.8299993 0.343 NA NA
PIK3CA erlotinib 0.3473764 0.8299993 0.347 NA NA
BRCA1 erlotinib 0.3656704 0.8299993 0.366 NA NA
ETV6 erlotinib 0.3694510 0.8299993 0.369 NA NA
RET erlotinib 0.3769409 0.8299993 0.377 NA NA
EGFR erlotinib 0.3780620 0.8299993 0.378 NA NA
AKT3 erlotinib 0.3831353 0.8299993 0.383 NA NA
CTNNB1 erlotinib 0.3868718 0.8299993 0.387 NA NA
KIT erlotinib 0.3945572 0.8299993 0.395 NA NA
NCOA2 erlotinib 0.3950763 0.8299993 0.395 NA NA
NOTCH1 erlotinib 0.4015628 0.8299993 0.402 NA NA
NPM1 erlotinib 0.4081068 0.8299993 0.408 NA NA
AKT1 erlotinib 0.4089836 0.8299993 0.409 NA NA
TSC2 erlotinib 0.4143017 0.8299993 0.414 NA NA
HRAS erlotinib 0.4181676 0.8299993 0.418 NA NA
JAK2 irinotecan 0.0704563 0.8326652 0.0705 NA NA
SETBP1 erlotinib 0.4301182 0.8409775 0.430 NA NA
SMC3 erlotinib 0.4530753 0.8457483 0.453 NA NA
FLT3 erlotinib 0.4536996 0.8457483 0.454 NA NA
SRSF2 erlotinib 0.4661229 0.8457483 0.466 NA NA
MDM2 erlotinib 0.4709707 0.8457483 0.471 NA NA
FBXW7 erlotinib 0.4790992 0.8457483 0.479 NA NA
DDIT3 erlotinib 0.4794295 0.8457483 0.479 NA NA
BCORL1 erlotinib 0.4833897 0.8457483 0.483 NA NA
TPMT erlotinib 0.4842070 0.8457483 0.484 NA NA
CD79B erlotinib 0.4933583 0.8503939 0.493 NA NA
PAX8 nilotinib 0.0106011 0.8522061 0.011
NA
ERBB3 nilotinib 0.0219026 0.8522061 0.022
NA
XPO1 nilotinib 0.0251623 0.8522061 0.025
NA
MAP2K2 nilotinib 0.0477901 0.8522061 0.048
NA
UGT1A1 nilotinib 0.0574932 0.8522061 0.057 NA NA
WHSC1 nilotinib 0.0752617 0.8522061 0.075 NA NA
BRAF nilotinib 0.0823341 0.8522061 0.082 NA NA
ZRSR2 nilotinib 0.0823935 0.8522061 0.082 NA NA
MAP2K1 nilotinib 0.0869990 0.8522061 0.087 NA NA
CBLB nilotinib 0.0920561 0.8522061 0.092 NA NA
NCOA2 nilotinib 0.0971203 0.8522061 0.097 NA NA
G6PD nilotinib 0.0978349 0.8522061 0.098 NA NA
PIGA nilotinib 0.1007178 0.8522061 0.101 NA NA
AKT1 nilotinib 0.1319214 0.8522061 0.132 NA NA
CD274 nilotinib 0.1500406 0.8522061 0.150 NA NA
EML4 nilotinib 0.1557059 0.8522061 0.156 NA NA
ERBB4 nilotinib 0.1674099 0.8522061 0.167 NA NA
GNA11 nilotinib 0.1690832 0.8522061 0.169 NA NA
DPYD nilotinib 0.1716871 0.8522061 0.172 NA NA
CDC73 nilotinib 0.1737485 0.8522061 0.174 NA NA
IDH2 nilotinib 0.1844993 0.8522061 0.184 NA NA
PHF6 nilotinib 0.1953337 0.8522061 0.195 NA NA
FBXW7 nilotinib 0.1956027 0.8522061 0.196 NA NA
EED nilotinib 0.1957988 0.8522061 0.196 NA NA
ATM nilotinib 0.1967220 0.8522061 0.197 NA NA
CEBPA nilotinib 0.1968300 0.8522061 0.197 NA NA
DNAJB1 nilotinib 0.2009226 0.8522061 0.201 NA NA
IKZF1 nilotinib 0.2030879 0.8522061 0.203 NA NA
JAK3 nilotinib 0.2106747 0.8522061 0.211 NA NA
CDK6 nilotinib 0.2163351 0.8522061 0.216 NA NA
CALR nilotinib 0.2199033 0.8522061 0.220 NA NA
PRPF8 nilotinib 0.2273928 0.8522061 0.227 NA NA
ERBB2 nilotinib 0.2469369 0.8522061 0.247 NA NA
FANCL nilotinib 0.2544008 0.8522061 0.254 NA NA
PTEN nilotinib 0.2586912 0.8522061 0.259 NA NA
PDGFB nilotinib 0.2614178 0.8522061 0.261 NA NA
GNB1 nilotinib 0.2703894 0.8522061 0.270 NA NA
CRLF2 nilotinib 0.2819017 0.8522061 0.282 NA NA
RPL10 nilotinib 0.2850268 0.8522061 0.285 NA NA
KRAS nilotinib 0.2905710 0.8522061 0.291 NA NA
IDH1 nilotinib 0.2908172 0.8522061 0.291 NA NA
SETBP1 nilotinib 0.2960817 0.8522061 0.296 NA NA
PIK3CA nilotinib 0.2965860 0.8522061 0.297 NA NA
DDIT3 nilotinib 0.3025069 0.8522061 0.303 NA NA
CDK4 nilotinib 0.3095790 0.8522061 0.310 NA NA
SH2B3 nilotinib 0.3095790 0.8522061 0.310 NA NA
SMC3 nilotinib 0.3146584 0.8522061 0.315 NA NA
GATA1 nilotinib 0.3176333 0.8522061 0.318 NA NA
JAK2 nilotinib 0.3242397 0.8522061 0.324 NA NA
STAT3 nilotinib 0.3252695 0.8522061 0.325 NA NA
FGFR2 selumetinib 0.2084067 0.8531649 0.20841 NA NA
FGFR3 erlotinib 0.5057821 0.8604865 0.506 NA NA
CDK4 irinotecan 0.0868856 0.8671396 0.0869 NA NA
FGFR2 irinotecan 0.0873862 0.8671396 0.0874 NA NA
AKT1 irinotecan 0.0995560 0.8671396 0.0996 NA NA
CDC73 irinotecan 0.1207285 0.8671396 0.1207 NA NA
BRAF irinotecan 0.1223433 0.8671396 0.1223 NA NA
EML4 irinotecan 0.1225636 0.8671396 0.1226 NA NA
ATM irinotecan 0.1329381 0.8671396 0.1329 NA NA
GNB1 irinotecan 0.1580732 0.8671396 0.1581 NA NA
ERBB4 irinotecan 0.1615181 0.8671396 0.1615 NA NA
ESR1 irinotecan 0.1628356 0.8671396 0.1628 NA NA
CTLA4 irinotecan 0.1702373 0.8671396 0.1702 NA NA
TPMT irinotecan 0.1771488 0.8671396 0.1771 NA NA
PAX5 irinotecan 0.1910949 0.8671396 0.1911 NA NA
IKZF1 irinotecan 0.1945005 0.8671396 0.1945 NA NA
CD79B irinotecan 0.1953386 0.8671396 0.1953 NA NA
PDGFRB irinotecan 0.2131484 0.8671396 0.2131 NA NA
EGFR irinotecan 0.2306603 0.8671396 0.2307 NA NA
CREBBP irinotecan 0.2415640 0.8671396 0.2416 NA NA
MGMT irinotecan 0.2444998 0.8671396 0.2445 NA NA
BRCA2 irinotecan 0.2519045 0.8671396 0.2519 NA NA
SETBP1 irinotecan 0.2535542 0.8671396 0.2536 NA NA
PRPF40B irinotecan 0.2545052 0.8671396 0.2545 NA NA
DPYD irinotecan 0.2565617 0.8671396 0.2566 NA NA
U2AF1 irinotecan 0.2686219 0.8671396 0.2686 NA NA
TP53 irinotecan 0.2699212 0.8671396 0.2699 NA NA
DNMT3A irinotecan 0.2699431 0.8671396 0.2699 NA NA
IL7R irinotecan 0.2748197 0.8671396 0.2748 NA NA
ETV6 irinotecan 0.2759762 0.8671396 0.2760 NA NA
GNAS irinotecan 0.2798045 0.8671396 0.2798 NA NA
GNA11 irinotecan 0.2837623 0.8671396 0.2838 NA NA
STAG2 irinotecan 0.2896816 0.8671396 0.2897 NA NA
RIT1 irinotecan 0.2916381 0.8671396 0.2916 NA NA
GATA3 irinotecan 0.2950313 0.8671396 0.2950 NA NA
CALR irinotecan 0.3188346 0.8671396 0.3188 NA NA
PIK3CA irinotecan 0.3207286 0.8671396 0.3207 NA NA
CYP19A1 irinotecan 0.3281397 0.8671396 0.3281 NA NA
RAD21 irinotecan 0.3328997 0.8671396 0.3329 NA NA
STAT3 irinotecan 0.3391154 0.8671396 0.3391 NA NA
PAX8 irinotecan 0.3425029 0.8671396 0.3425 NA NA
GATA2 irinotecan 0.3492471 0.8671396 0.3492 NA NA
SF1 irinotecan 0.3571830 0.8671396 0.3572 NA NA
MET irinotecan 0.3595819 0.8671396 0.3596 NA NA
MYD88 irinotecan 0.3660517 0.8671396 0.3661 NA NA
AR irinotecan 0.3668667 0.8671396 0.3669 NA NA
FLCN lapatinib 0.2981455 0.8679347 0.298 NA NA
CD79B nilotinib 0.3432244 0.8696666 0.343 NA NA
ASXL1 nilotinib 0.3452112 0.8696666 0.345 NA NA
GATA1 lapatinib 0.3258106 0.8729795 0.326 NA NA
NCOA2 lapatinib 0.3280718 0.8729795 0.328 NA NA
STAT3 lapatinib 0.3335387 0.8729795 0.334 NA NA
EZH2 lapatinib 0.3363420 0.8729795 0.336 NA NA
IDH1 lapatinib 0.3512958 0.8729795 0.351 NA NA
FGFR1 lapatinib 0.3538617 0.8729795 0.354 NA NA
EML4 lapatinib 0.3576785 0.8729795 0.358 NA NA
SMO lapatinib 0.3610953 0.8729795 0.361 NA NA
RPL10 lapatinib 0.3697756 0.8729795 0.370 NA NA
KRAS lapatinib 0.3717079 0.8729795 0.372 NA NA
BTK lapatinib 0.3783216 0.8729795 0.378 NA NA
MAP2K1 lapatinib 0.3798461 0.8729795 0.380 NA NA
EGF nilotinib 0.3535275 0.8738133 0.354 NA NA
CYP19A1 nilotinib 0.3614358 0.8768164 0.361 NA NA
AKT3 lapatinib 0.3897579 0.8803152 0.390 NA NA
MAP2K1 erlotinib 0.5270899 0.8852407 0.527 NA NA
MET nilotinib 0.3749787 0.8877627 0.375 NA NA
SRSF2 nilotinib 0.3795016 0.8877627 0.380 NA NA
ESR1 erlotinib 0.5463206 0.8939785 0.546 NA NA
VHL erlotinib 0.5488405 0.8939785 0.549 NA NA
FLCN erlotinib 0.5527653 0.8939785 0.553 NA NA
HRAS lapatinib 0.4223510 0.9047072 0.422 NA NA
MPL lapatinib 0.4272603 0.9047072 0.427 NA NA
WHSC1 lapatinib 0.4278387 0.9047072 0.428 NA NA
PIK3CA lapatinib 0.4324195 0.9047072 0.432 NA NA
ABL1 lapatinib 0.4453225 0.9047072 0.445 NA NA
GNB1 lapatinib 0.4579231 0.9047072 0.458 NA NA
MYD88 lapatinib 0.4587151 0.9047072 0.459 NA NA
ALK lapatinib 0.4609038 0.9047072 0.461 NA NA
PAX8 lapatinib 0.4777998 0.9047072 0.478 NA NA
GNA11 lapatinib 0.4911808 0.9047072 0.491 NA NA
DPYD lapatinib 0.4951753 0.9047072 0.495 NA NA
CTCF lapatinib 0.5174017 0.9047072 0.517 NA NA
BRCA1 lapatinib 0.5346294 0.9047072 0.535 NA NA
GATA3 lapatinib 0.5384377 0.9047072 0.538 NA NA
IL7R lapatinib 0.5439112 0.9047072 0.544 NA NA
IKZF1 lapatinib 0.5493652 0.9047072 0.549 NA NA
ATM lapatinib 0.5550964 0.9047072 0.555 NA NA
MET lapatinib 0.5678884 0.9047072 0.568 NA NA
EGF lapatinib 0.5756426 0.9047072 0.576 NA NA
GATA2 lapatinib 0.5776923 0.9047072 0.578 NA NA
PDGFRB lapatinib 0.5810825 0.9047072 0.581 NA NA
CTNNB1 lapatinib 0.5823848 0.9047072 0.582 NA NA
JAK1 lapatinib 0.5848719 0.9047072 0.585 NA NA
UGT1A1 lapatinib 0.5880643 0.9047072 0.588 NA NA
RIT1 lapatinib 0.5908467 0.9047072 0.591 NA NA
GNAS lapatinib 0.5958805 0.9047072 0.596 NA NA
CDK4 lapatinib 0.5976694 0.9047072 0.598 NA NA
SETD2 lapatinib 0.6015271 0.9047072 0.602 NA NA
AKT1 lapatinib 0.6019637 0.9047072 0.602 NA NA
CDKN2A lapatinib 0.6158264 0.9047072 0.616 NA NA
RUNX1 lapatinib 0.6166705 0.9047072 0.617 NA NA
JAK3 lapatinib 0.6237232 0.9047072 0.624 NA NA
G6PD lapatinib 0.6332410 0.9047072 0.633 NA NA
SETBP1 lapatinib 0.6353669 0.9047072 0.635 NA NA
NRAS irinotecan 0.3909888 0.9076525 0.3910 NA NA
PAX5 nilotinib 0.3950175 0.9078473 0.395 NA NA
SMC1A lapatinib 0.6516111 0.9092433 0.652 NA NA
CBL lapatinib 0.6524341 0.9092433 0.652 NA NA
CYP19A1 erlotinib 0.5725012 0.9146055 0.573 NA NA
PRPF40B erlotinib 0.5871846 0.9169446 0.587 NA NA
IL7R erlotinib 0.5879645 0.9169446 0.588 NA NA
AR lapatinib 0.6705630 0.9246710 0.671 NA NA
GNAQ nilotinib 0.4094761 0.9248512 0.409 NA NA
ALK irinotecan 0.4159284 0.9343904 0.4159 NA NA
MAP2K1 irinotecan 0.4180667 0.9343904 0.4181 NA NA
VHL irinotecan 0.4240695 0.9343904 0.4241 NA NA
CBL erlotinib 0.6066026 0.9348817 0.607 NA NA
FANCL selumetinib 0.2375039 0.9379023 0.23750 NA NA
NOTCH1 selumetinib 0.2510449 0.9379023 0.25104 NA NA
VHL selumetinib 0.2554789 0.9379023 0.25548 NA NA
PAX8 selumetinib 0.2784348 0.9379023 0.27843 NA NA
SMC3 selumetinib 0.2800304 0.9379023 0.28003 NA NA
GATA1 selumetinib 0.2877975 0.9379023 0.28780 NA NA
RIT1 selumetinib 0.2890366 0.9379023 0.28904 NA NA
NT5C2 selumetinib 0.2993317 0.9379023 0.29933 NA NA
TSC1 selumetinib 0.3026265 0.9379023 0.30263 NA NA
CBL selumetinib 0.3063751 0.9379023 0.30638 NA NA
RET selumetinib 0.3162948 0.9379023 0.31629 NA NA
MAP2K2 selumetinib 0.3219772 0.9379023 0.32198 NA NA
GATA2 selumetinib 0.3395397 0.9379023 0.33954 NA NA
GATA3 selumetinib 0.3459306 0.9379023 0.34593 NA NA
BTK selumetinib 0.3507388 0.9379023 0.35074 NA NA
CYP19A1 selumetinib 0.3657355 0.9379023 0.36574 NA NA
CEBPA selumetinib 0.3714072 0.9379023 0.37141 NA NA
TP53 selumetinib 0.3730400 0.9379023 0.37304 NA NA
CDK4 selumetinib 0.3739875 0.9379023 0.37399 NA NA
CD79B selumetinib 0.3789936 0.9379023 0.37899 NA NA
SF3B1 selumetinib 0.3794567 0.9379023 0.37946 NA NA
PIGA lapatinib 0.6899301 0.9387284 0.690 NA NA
CYP19A1 lapatinib 0.6950890 0.9387284 0.695 NA NA
SMC1A selumetinib 0.3873961 0.9397942 0.38740 NA NA
CBLB selumetinib 0.3957166 0.9425251 0.39572 NA NA
CDK6 selumetinib 0.4197911 0.9453281 0.41979 NA NA
RAD21 selumetinib 0.4202363 0.9453281 0.42024 NA NA
KIT selumetinib 0.4291048 0.9453281 0.42910 NA NA
SETBP1 selumetinib 0.4352803 0.9453281 0.43528 NA NA
GNB1 selumetinib 0.4390316 0.9453281 0.43903 NA NA
FBXW7 selumetinib 0.4403523 0.9453281 0.44035 NA NA
ESR1 selumetinib 0.4556101 0.9453281 0.45561 NA NA
CD274 selumetinib 0.4672104 0.9453281 0.46721 NA NA
CTLA4 selumetinib 0.4717193 0.9453281 0.47172 NA NA
STAT3 selumetinib 0.4741982 0.9453281 0.47420 NA NA
CRLF2 selumetinib 0.4762722 0.9453281 0.47627 NA NA
ZRSR2 lapatinib 0.7127565 0.9527664 0.713 NA NA
TSC1 erlotinib 0.6505989 0.9563686 0.651 NA NA
GATA1 erlotinib 0.6580401 0.9563686 0.658 NA NA
GNB1 erlotinib 0.6685175 0.9563686 0.669 NA NA
DPYD erlotinib 0.6840148 0.9563686 0.684 NA NA
BTK erlotinib 0.6873166 0.9563686 0.687 NA NA
IKZF1 erlotinib 0.7003041 0.9563686 0.700 NA NA
NRAS erlotinib 0.7042626 0.9563686 0.704 NA NA
RIT1 erlotinib 0.7055740 0.9563686 0.706 NA NA
WHSC1 erlotinib 0.7063712 0.9563686 0.706 NA NA
PTPN11 erlotinib 0.7104107 0.9563686 0.710 NA NA
SSX1 erlotinib 0.7213924 0.9563686 0.721 NA NA
ATM erlotinib 0.7248163 0.9563686 0.725 NA NA
JAK3 erlotinib 0.7290446 0.9563686 0.729 NA NA
PTCH1 erlotinib 0.7302464 0.9563686 0.730 NA NA
EZH2 erlotinib 0.7344706 0.9563686 0.734 NA NA
RUNX1 erlotinib 0.7408697 0.9563686 0.741 NA NA
JAK1 erlotinib 0.7446534 0.9563686 0.745 NA NA
BRCA2 nilotinib 0.4329522 0.9569263 0.433 NA NA
DNMT3A nilotinib 0.4393202 0.9569263 0.439 NA NA
RAD21 nilotinib 0.4455916 0.9569263 0.446 NA NA
SH2B3 lapatinib 0.7233868 0.9572087 0.723 NA NA
MPL nilotinib 0.4540395 0.9593416 0.454 NA NA
PDGFRB nilotinib 0.4795241 0.9607015 0.480 NA NA
NT5C2 nilotinib 0.4985874 0.9607015 0.499 NA NA
ESR1 nilotinib 0.5209092 0.9607015 0.521 NA NA
NPM1 nilotinib 0.5225901 0.9607015 0.523 NA NA
ETV6 nilotinib 0.5231112 0.9607015 0.523 NA NA
VHL nilotinib 0.5249231 0.9607015 0.525 NA NA
TP53 nilotinib 0.5288472 0.9607015 0.529 NA NA
CDKN2A nilotinib 0.5300461 0.9607015 0.530 NA NA
PRPF40B nilotinib 0.5310239 0.9607015 0.531 NA NA
NOTCH2 nilotinib 0.5393383 0.9607015 0.539 NA NA
PDCD1 nilotinib 0.5606283 0.9607015 0.561 NA NA
SMO nilotinib 0.5711686 0.9607015 0.571 NA NA
CTNNB1 nilotinib 0.5810417 0.9607015 0.581 NA NA
CSF3R nilotinib 0.5848095 0.9607015 0.585 NA NA
SSX1 nilotinib 0.5863196 0.9607015 0.586 NA NA
FLT3 nilotinib 0.5913464 0.9607015 0.591 NA NA
RET nilotinib 0.5975829 0.9607015 0.598 NA NA
NRAS nilotinib 0.5977193 0.9607015 0.598 NA NA
CBL nilotinib 0.6047466 0.9607015 0.605 NA NA
PTPN11 nilotinib 0.6063462 0.9607015 0.606 NA NA
SF1 nilotinib 0.6086888 0.9607015 0.609 NA NA
BTK irinotecan 0.4499106 0.9616095 0.4499 NA NA
CD274 irinotecan 0.4598390 0.9616095 0.4598 NA NA
DNAJB1 irinotecan 0.4725298 0.9616095 0.4725 NA NA
SMC3 irinotecan 0.4778543 0.9616095 0.4779 NA NA
PHF6 irinotecan 0.4809070 0.9616095 0.4809 NA NA
ROS1 irinotecan 0.4834670 0.9616095 0.4835 NA NA
NOTCH1 irinotecan 0.5083990 0.9616095 0.5084 NA NA
PDGFB irinotecan 0.5117862 0.9616095 0.5118 NA NA
TET2 irinotecan 0.5145990 0.9616095 0.5146 NA NA
PTPN11 irinotecan 0.5165017 0.9616095 0.5165 NA NA
IDH1 irinotecan 0.5177897 0.9616095 0.5178 NA NA
HRAS selumetinib 0.4931995 0.9643155 0.49320 NA NA
ERBB4 erlotinib 0.7781237 0.9658067 0.778 NA NA
G6PD erlotinib 0.7787902 0.9658067 0.779 NA NA
FGFR1 erlotinib 0.7800078 0.9658067 0.780 NA NA
KMT2A erlotinib 0.7907716 0.9658067 0.791 NA NA
GNAS erlotinib 0.7962137 0.9658067 0.796 NA NA
PAX8 erlotinib 0.7962376 0.9658067 0.796 NA NA
TSC1 lapatinib 0.7401698 0.9696225 0.740 NA NA
PRPF40B lapatinib 0.7523713 0.9698092 0.752 NA NA
CDC73 lapatinib 0.7574639 0.9698092 0.757 NA NA
FGFR3 lapatinib 0.7703491 0.9698092 0.770 NA NA
MAP2K2 lapatinib 0.7714479 0.9698092 0.771 NA NA
SMC3 lapatinib 0.7862153 0.9698092 0.786 NA NA
PTCH1 lapatinib 0.7871784 0.9698092 0.787 NA NA
EGFR lapatinib 0.7947247 0.9698092 0.795 NA NA
ERBB4 lapatinib 0.8042029 0.9698092 0.804 NA NA
IDH2 lapatinib 0.8145125 0.9698092 0.815 NA NA
SSX1 lapatinib 0.8176005 0.9698092 0.818 NA NA
CD79B lapatinib 0.8217468 0.9698092 0.822 NA NA
MPL erlotinib 0.8134653 0.9720100 0.813 NA NA
UGT1A1 erlotinib 0.8238031 0.9720100 0.824 NA NA
PDGFRB erlotinib 0.8279937 0.9720100 0.828 NA NA
FANCL erlotinib 0.8310314 0.9720100 0.831 NA NA
IDH2 irinotecan 0.5383687 0.9726121 0.5384 NA NA
SRSF2 irinotecan 0.5486376 0.9726121 0.5486 NA NA
KMT2A irinotecan 0.5662482 0.9726121 0.5662 NA NA
CEBPA irinotecan 0.5694611 0.9726121 0.5695 NA NA
PIGA irinotecan 0.5810477 0.9726121 0.5810 NA NA
PDGFRA irinotecan 0.5925752 0.9726121 0.5926 NA NA
NT5C2 irinotecan 0.5962588 0.9726121 0.5963 NA NA
JAK3 irinotecan 0.5999452 0.9726121 0.5999 NA NA
TSC1 irinotecan 0.6014923 0.9726121 0.6015 NA NA
ERBB2 irinotecan 0.6286426 0.9726121 0.6286 NA NA
PML irinotecan 0.6294330 0.9726121 0.6294 NA NA
FANCL irinotecan 0.6327514 0.9726121 0.6328 NA NA
CXCR4 irinotecan 0.6348669 0.9726121 0.6349 NA NA
RET irinotecan 0.6389716 0.9726121 0.6390 NA NA
AKT3 irinotecan 0.6506008 0.9726121 0.6506 NA NA
WHSC1 irinotecan 0.6542440 0.9726121 0.6542 NA NA
PDCD1 irinotecan 0.6545590 0.9726121 0.6546 NA NA
ABL1 irinotecan 0.6660281 0.9726121 0.6660 NA NA
CTNNB1 irinotecan 0.6690072 0.9726121 0.6690 NA NA
EZH2 irinotecan 0.6733468 0.9726121 0.6733 NA NA
NT5C2 erlotinib 0.8425719 0.9767869 0.843 NA NA
PRPF8 irinotecan 0.7015023 0.9775516 0.7015 NA NA
PTCH1 irinotecan 0.7162618 0.9775516 0.7163 NA NA
SF3B1 irinotecan 0.7173061 0.9775516 0.7173 NA NA
CBLB irinotecan 0.7342163 0.9775516 0.7342 NA NA
GATA1 irinotecan 0.7510689 0.9775516 0.7511 NA NA
RPL10 irinotecan 0.7548056 0.9775516 0.7548 NA NA
SMC1A irinotecan 0.7580493 0.9775516 0.7580 NA NA
FGFR3 irinotecan 0.7590167 0.9775516 0.7590 NA NA
CRLF2 irinotecan 0.7651322 0.9775516 0.7651 NA NA
SSX1 irinotecan 0.7716424 0.9775516 0.7716 NA NA
HRAS irinotecan 0.7830688 0.9775516 0.7831 NA NA
RUNX1 irinotecan 0.7975944 0.9775516 0.7976 NA NA
SMO irinotecan 0.7988480 0.9775516 0.7988 NA NA
AKT2 irinotecan 0.8069935 0.9775516 0.8070 NA NA
CSF3R irinotecan 0.8191014 0.9775516 0.8191 NA NA
XPO1 irinotecan 0.8196641 0.9775516 0.8197 NA NA
BRCA1 irinotecan 0.8210965 0.9775516 0.8211 NA NA
G6PD irinotecan 0.8254252 0.9775516 0.8254 NA NA
UGT1A1 irinotecan 0.8309879 0.9775516 0.8310 NA NA
NCOA2 irinotecan 0.8517003 0.9775516 0.8517 NA NA
KIT irinotecan 0.8862231 0.9775516 0.8862 NA NA
FGFR1 irinotecan 0.8871126 0.9775516 0.8871 NA NA
NPM1 irinotecan 0.8930026 0.9775516 0.8930 NA NA
CBL irinotecan 0.9079854 0.9775516 0.9080 NA NA
ASXL1 irinotecan 0.9089550 0.9775516 0.9090 NA NA
FLCN irinotecan 0.9219343 0.9775516 0.9219 NA NA
CTCF irinotecan 0.9262120 0.9775516 0.9262 NA NA
EGF irinotecan 0.9294390 0.9775516 0.9294 NA NA
CDK6 irinotecan 0.9369407 0.9775516 0.9369 NA NA
BCOR irinotecan 0.9384232 0.9775516 0.9384 NA NA
PTEN irinotecan 0.9404034 0.9775516 0.9404 NA NA
SH2B3 irinotecan 0.9413890 0.9775516 0.9414 NA NA
MPL irinotecan 0.9419762 0.9775516 0.9420 NA NA
MDM2 irinotecan 0.9444299 0.9775516 0.9444 NA NA
WT1 irinotecan 0.9470140 0.9775516 0.9470 NA NA
MAP2K2 irinotecan 0.9474730 0.9775516 0.9475 NA NA
DDIT3 lapatinib 0.8377397 0.9777206 0.838 NA NA
KMT2A lapatinib 0.8454470 0.9777206 0.845 NA NA
FLT3 lapatinib 0.8614733 0.9777206 0.861 NA NA
BCOR lapatinib 0.8638970 0.9777206 0.864 NA NA
NT5C2 lapatinib 0.8753678 0.9777206 0.875 NA NA
BCORL1 lapatinib 0.8806185 0.9777206 0.881 NA NA
STAG2 lapatinib 0.8834116 0.9777206 0.883 NA NA
PRPF8 lapatinib 0.8893234 0.9777206 0.889 NA NA
TPMT lapatinib 0.9089736 0.9777206 0.909 NA NA
CDK6 lapatinib 0.9113470 0.9777206 0.911 NA NA
PAX5 lapatinib 0.9176528 0.9777206 0.918 NA NA
AKT2 lapatinib 0.9180125 0.9777206 0.918 NA NA
ABL1 erlotinib 0.8522490 0.9793387 0.852 NA NA
TET2 erlotinib 0.8613977 0.9812444 0.861 NA NA
BCORL1 irinotecan 0.9680876 0.9827803 0.9681 NA NA
ERBB3 irinotecan 0.9705439 0.9827803 0.9705 NA NA
CDKN2A irinotecan 0.9752204 0.9827803 0.9752 NA NA
CTCF nilotinib 0.6405142 0.9855023 0.641 NA NA
KIT nilotinib 0.6606331 0.9855023 0.661 NA NA
TPMT nilotinib 0.6679929 0.9855023 0.668 NA NA
JAK1 nilotinib 0.6683405 0.9855023 0.668 NA NA
AKT3 nilotinib 0.6789529 0.9855023 0.679 NA NA
FGFR1 nilotinib 0.6796758 0.9855023 0.680 NA NA
ROS1 nilotinib 0.6819122 0.9855023 0.682 NA NA
MYD88 nilotinib 0.6912056 0.9855023 0.691 NA NA
TSC2 nilotinib 0.6921085 0.9855023 0.692 NA NA
CDKN2A erlotinib 0.8747139 0.9864676 0.875 NA NA
STAT3 erlotinib 0.8844399 0.9864676 0.884 NA NA
MYD88 erlotinib 0.8885739 0.9864676 0.889 NA NA
EML4 selumetinib 0.5261206 0.9881245 0.52612 NA NA
AKT2 selumetinib 0.5332426 0.9881245 0.53324 NA NA
FGFR3 selumetinib 0.5504813 0.9881245 0.55048 NA NA
CREBBP selumetinib 0.5551165 0.9881245 0.55512 NA NA
PTPN11 selumetinib 0.5722801 0.9881245 0.57228 NA NA
EGFR selumetinib 0.5763443 0.9881245 0.57634 NA NA
JAK3 selumetinib 0.5791652 0.9881245 0.57917 NA NA
CALR selumetinib 0.5793494 0.9881245 0.57935 NA NA
MAP2K1 selumetinib 0.5850648 0.9881245 0.58506 NA NA
TSC2 selumetinib 0.6111574 0.9881245 0.61116 NA NA
ATM selumetinib 0.6349288 0.9881245 0.63493 NA NA
CDC73 selumetinib 0.6511899 0.9881245 0.65119 NA NA
MET selumetinib 0.6524774 0.9881245 0.65248 NA NA
U2AF1 selumetinib 0.6577081 0.9881245 0.65771 NA NA
IKZF1 selumetinib 0.6611150 0.9881245 0.66111 NA NA
ABL1 selumetinib 0.6628862 0.9881245 0.66289 NA NA
PDGFRB selumetinib 0.6645199 0.9881245 0.66452 NA NA
PRPF40B selumetinib 0.6689523 0.9881245 0.66895 NA NA
MDM2 selumetinib 0.6727814 0.9881245 0.67278 NA NA
CTNNB1 selumetinib 0.6746071 0.9881245 0.67461 NA NA
EED selumetinib 0.6798049 0.9881245 0.67980 NA NA
FLCN selumetinib 0.6802253 0.9881245 0.68023 NA NA
EGF selumetinib 0.6802678 0.9881245 0.68027 NA NA
DPYD selumetinib 0.6868738 0.9881245 0.68687 NA NA
PDCD1 selumetinib 0.7186602 0.9881245 0.71866 NA NA
NOTCH2 selumetinib 0.7202092 0.9881245 0.72021 NA NA
DDIT3 selumetinib 0.7243926 0.9881245 0.72439 NA NA
MYD88 selumetinib 0.7246756 0.9881245 0.72468 NA NA
BCORL1 selumetinib 0.7333376 0.9881245 0.73334 NA NA
PIGA selumetinib 0.7421261 0.9881245 0.74213 NA NA
GNA11 selumetinib 0.7569104 0.9881245 0.75691 NA NA
NCOA2 selumetinib 0.7585886 0.9881245 0.75859 NA NA
PDGFB selumetinib 0.7634636 0.9881245 0.76346 NA NA
AR selumetinib 0.7836835 0.9881245 0.78368 NA NA
PHF6 selumetinib 0.7908963 0.9881245 0.79090 NA NA
SSX1 selumetinib 0.7987359 0.9881245 0.79874 NA NA
WT1 selumetinib 0.8117996 0.9881245 0.81180 NA NA
DNAJB1 selumetinib 0.8178008 0.9881245 0.81780 NA NA
ERBB2 selumetinib 0.8218228 0.9881245 0.82182 NA NA
ROS1 selumetinib 0.8271911 0.9881245 0.82719 NA NA
ALK selumetinib 0.8278795 0.9881245 0.82788 NA NA
FGFR1 selumetinib 0.8422202 0.9881245 0.84222 NA NA
ERBB4 selumetinib 0.8446106 0.9881245 0.84461 NA NA
FLT3 selumetinib 0.8527746 0.9881245 0.85277 NA NA
SETD2 selumetinib 0.8627670 0.9881245 0.86277 NA NA
RPL10 selumetinib 0.8658058 0.9881245 0.86581 NA NA
ERBB3 selumetinib 0.8669447 0.9881245 0.86694 NA NA
CTCF selumetinib 0.8706349 0.9881245 0.87063 NA NA
NPM1 selumetinib 0.8832243 0.9881245 0.88322 NA NA
UGT1A1 selumetinib 0.8917738 0.9881245 0.89177 NA NA
AKT1 selumetinib 0.9187209 0.9881245 0.91872 NA NA
PAX5 selumetinib 0.9213643 0.9881245 0.92136 NA NA
MGMT selumetinib 0.9254057 0.9881245 0.92541 NA NA
IL7R selumetinib 0.9287200 0.9881245 0.92872 NA NA
CXCR4 selumetinib 0.9335671 0.9881245 0.93357 NA NA
SF1 selumetinib 0.9388121 0.9881245 0.93881 NA NA
TET2 selumetinib 0.9390759 0.9881245 0.93908 NA NA
SH2B3 selumetinib 0.9448071 0.9881245 0.94481 NA NA
PML selumetinib 0.9504098 0.9881245 0.95041 NA NA
BRCA1 selumetinib 0.9592240 0.9888743 0.95922 NA NA
XPO1 selumetinib 0.9668163 0.9888743 0.96682 NA NA
GNAQ selumetinib 0.9752766 0.9888743 0.97528 NA NA
TPMT selumetinib 0.9863877 0.9888743 0.98639 NA NA
MYCN selumetinib 0.9888743 0.9888743 0.98887 NA NA
PHF6 lapatinib 0.9451994 0.9895734 0.945 NA NA
PTEN lapatinib 0.9516739 0.9895734 0.952 NA NA
ESR1 lapatinib 0.9641363 0.9895734 0.964 NA NA
CXCR4 lapatinib 0.9673812 0.9895734 0.967 NA NA
PTPN11 lapatinib 0.9711271 0.9895734 0.971 NA NA
FGFR2 lapatinib 0.9842030 0.9895734 0.984 NA NA
SF3B1 lapatinib 0.9865575 0.9895734 0.987 NA NA
CSF3R lapatinib 0.9895734 0.9895734 0.990 NA NA
DNMT3A erlotinib 0.9005581 0.9898541 0.901 NA NA
GATA3 erlotinib 0.9119616 0.9898541 0.912 NA NA
ALK erlotinib 0.9492432 0.9898541 0.949 NA NA
AKT2 erlotinib 0.9628110 0.9898541 0.963 NA NA
CDK6 erlotinib 0.9761607 0.9898541 0.976 NA NA
PAX5 erlotinib 0.9776368 0.9898541 0.978 NA NA
SETD2 erlotinib 0.9776368 0.9898541 0.978 NA NA
SF3B1 erlotinib 0.9789551 0.9898541 0.979 NA NA
TP53 erlotinib 0.9801201 0.9898541 0.980 NA NA
RPL10 erlotinib 0.9825514 0.9898541 0.983 NA NA
BCOR erlotinib 0.9848467 0.9898541 0.985 NA NA
PRPF8 erlotinib 0.9895951 0.9898541 0.990 NA NA
SH2B3 erlotinib 0.9898541 0.9898541 0.990 NA NA
BTK nilotinib 0.7312736 0.9919192 0.731 NA NA
TET2 nilotinib 0.7479864 0.9919192 0.748 NA NA
FGFR3 nilotinib 0.7486898 0.9919192 0.749 NA NA
FLCN nilotinib 0.7541296 0.9919192 0.754 NA NA
SETD2 nilotinib 0.7552064 0.9919192 0.755 NA NA
CREBBP nilotinib 0.7621143 0.9919192 0.762 NA NA
CTLA4 nilotinib 0.7791419 0.9919192 0.779 NA NA
BCOR nilotinib 0.7961781 0.9919192 0.796 NA NA
GATA3 nilotinib 0.7977219 0.9919192 0.798 NA NA
SMC1A nilotinib 0.7980647 0.9919192 0.798 NA NA
ALK nilotinib 0.7983903 0.9919192 0.798 NA NA
TSC1 nilotinib 0.7988924 0.9919192 0.799 NA NA
GATA2 nilotinib 0.8059928 0.9919192 0.806 NA NA
RUNX1 nilotinib 0.8073074 0.9919192 0.807 NA NA
AR nilotinib 0.8128485 0.9919192 0.813 NA NA
MGMT nilotinib 0.8301945 0.9919192 0.830 NA NA
MYCN nilotinib 0.8448350 0.9919192 0.845 NA NA
IL7R nilotinib 0.8524502 0.9919192 0.852 NA NA
PDGFRA nilotinib 0.8621321 0.9919192 0.862 NA NA
CXCR4 nilotinib 0.8733725 0.9919192 0.873 NA NA
EZH2 nilotinib 0.8752021 0.9919192 0.875 NA NA
STAG2 nilotinib 0.8759840 0.9919192 0.876 NA NA
MDM2 nilotinib 0.8889052 0.9919192 0.889 NA NA
RIT1 nilotinib 0.8908541 0.9919192 0.891 NA NA
NOTCH1 nilotinib 0.8983617 0.9919192 0.898 NA NA
KMT2A nilotinib 0.9084944 0.9919192 0.908 NA NA
PML nilotinib 0.9170484 0.9919192 0.917 NA NA
U2AF1 nilotinib 0.9215704 0.9919192 0.922 NA NA
HRAS nilotinib 0.9225162 0.9919192 0.923 NA NA
AKT2 nilotinib 0.9311619 0.9919192 0.931 NA NA
FGFR2 nilotinib 0.9470949 0.9919192 0.947 NA NA
BRCA1 nilotinib 0.9506540 0.9919192 0.951 NA NA
PTCH1 nilotinib 0.9525059 0.9919192 0.953 NA NA
EGFR nilotinib 0.9540597 0.9919192 0.954 NA NA
MYCN irinotecan 0.9924251 0.9924251 0.9924 NA NA
GNAS nilotinib 0.9824645 0.9989982 0.982 NA NA
SF3B1 nilotinib 0.9834968 0.9989982 0.983 NA NA
WT1 nilotinib 0.9955641 0.9989982 0.996 NA NA
BCORL1 nilotinib 0.9957000 0.9989982 0.996 NA NA
ABL1 nilotinib 0.9989982 0.9989982 0.999 NA NA 
wilcox_ccle_gene_lvlA_plot <- ggplot(data = ccle_signif_lvlA) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_ccle_gene_lvlA_plot

5.2.4 CTRP: Gene and drug

ctrp_data_ptmuts <- filter(ctrp_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
ctrp_data_ptmuts$Keep_PtMut_Tests <- ifelse(ctrp_data_ptmuts$Reference_Allele_Length == 1 | is.na(ctrp_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(ctrp_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
ctrp_data_ptmuts <- filter(ctrp_data_ptmuts, Keep_PtMut_Tests == TRUE)
ctrp_data_lvlA <- filter(ctrp_data_ptmuts, Hugo_Symbol %in% genes_lvlA)
ctrp_signif_lvlA_ByDrug <- lapply(unique(ctrp_data_lvlA$Drug), WilcoxonByDrug, dataset = ctrp_data_lvlA, data_name = "CTRP")
names(ctrp_signif_lvlA_ByDrug) <- unique(ctrp_data_lvlA$Drug)
saveRDS(ctrp_signif_lvlA_ByDrug, "./data_munging/rds/ctrp_signif_lvlA_ByDrug.rds")

ctrp_signif_lvlA <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = c("Drug", "Hugo_Symbol"), data = ctrp_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
ctrp_signif_lvlA <- adj_signif(ctrp_signif_lvlA)
ctrp_signif_lvlA <- ctrp_signif_lvlA[order(ctrp_signif_lvlA$p),]
saveRDS(ctrp_signif_lvlA, "./data_munging/rds/ctrp_signif_lvlA_gene.rds")
ctrp_signif_lvlA <- readRDS("./data_munging/rds/ctrp_signif_lvlA_gene.rds")

knitr::kable(ctrp_signif_lvlA[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CTRP: Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
BRAF vemurafenib 0.0000005 0.0008694 4.9e-07 **** ***
PTEN afatinib 0.0000005 0.0008694 5.0e-07 **** ***
KRAS lapatinib 0.0000056 0.0065368 5.6e-06 **** **
KRAS trametinib 0.0000123 0.0108161 1.2e-05 ****
KRAS pazopanib 0.0000172 0.0120592 1.7e-05 ****
KRAS ibrutinib 0.0000293 0.0160639 2.9e-05 ****
MYD88 vemurafenib 0.0000321 0.0160639 3.2e-05 ****
PTEN lapatinib 0.0000569 0.0249108 5.7e-05 ****
PTEN sunitinib 0.0001751 0.0596293 0.00018 *** NA
KRAS selumetinib 0.0002012 0.0596293 0.00020 *** NA
BRAF selumetinib 0.0002081 0.0596293 0.00021 *** NA
PTEN neratinib 0.0002153 0.0596293 0.00022 *** NA
TP53 olaparib 0.0002233 0.0596293 0.00022 *** NA
BRAF olaparib 0.0002505 0.0596293 0.00025 *** NA
GATA3 cabozantinib 0.0002714 0.0596293 0.00027 *** NA
BRAF dabrafenib 0.0002722 0.0596293 0.00027 *** NA
CREBBP dasatinib 0.0003347 0.0690143 0.00033 *** NA
RUNX1 regorafenib 0.0004133 0.0765225 0.00041 *** NA
KRAS sunitinib 0.0004277 0.0765225 0.00043 *** NA
KRAS neratinib 0.0004366 0.0765225 0.00044 *** NA
EGFR vemurafenib 0.0006405 0.1034749 0.00064 *** NA
TP53 crizotinib 0.0006495 0.1034749 0.00065 *** NA
PAX8 regorafenib 0.0007275 0.1108639 0.00073 *** NA
TP53 cabozantinib 0.0007688 0.1122800 0.00077 *** NA
BRAF afatinib 0.0008985 0.1259665 0.00090 *** NA
KRAS vandetanib 0.0012628 0.1702386 0.00126 ** NA
HRAS sunitinib 0.0016468 0.2120876 0.00165 ** NA
DNMT3A vandetanib 0.0017460 0.2120876 0.00175 ** NA
ATM dasatinib 0.0017548 0.2120876 0.00175 ** NA
PTEN trametinib 0.0019075 0.2228565 0.00191 ** NA
KRAS cabozantinib 0.0020791 0.2350669 0.00208 ** NA
BCOR nilotinib 0.0022221 0.2433909 0.00222 ** NA
SMC1A vemurafenib 0.0023813 0.2529239 0.00238 ** NA
NRAS ibrutinib 0.0025472 0.2625880 0.00255 ** NA
PTEN gefitinib 0.0027031 0.2706975 0.00270 ** NA
DNMT3A lapatinib 0.0028992 0.2822676 0.00290 ** NA
GATA2 cabozantinib 0.0032752 0.3102600 0.00328 ** NA
CYP19A1 vemurafenib 0.0034645 0.3122344 0.00346 ** NA
TP53 pazopanib 0.0034742 0.3122344 0.00347 ** NA
KRAS olaparib 0.0035982 0.3152945 0.00360 ** NA
TP53 regorafenib 0.0038602 0.3207777 0.00386 ** NA
KRAS gefitinib 0.0040210 0.3207777 0.00402 ** NA
TET2 cabozantinib 0.0040527 0.3207777 0.00405 ** NA
BRAF neratinib 0.0041088 0.3207777 0.00411 ** NA
BRAF pazopanib 0.0041184 0.3207777 0.00412 ** NA
PRPF40B lapatinib 0.0047164 0.3593692 0.00472 ** NA
BRAF ibrutinib 0.0051142 0.3813925 0.00511 ** NA
DNMT3A selumetinib 0.0054340 0.3894881 0.00543 ** NA
PDGFRB imatinib 0.0054451 0.3894881 0.00545 ** NA
NRAS lapatinib 0.0058968 0.3993414 0.00590 ** NA
RUNX1 nilotinib 0.0060341 0.3993414 0.00603 ** NA
NCOA2 ibrutinib 0.0061756 0.3993414 0.00618 ** NA
PML fulvestrant 0.0061906 0.3993414 0.00619 ** NA
BRAF ruxolitinib 0.0062716 0.3993414 0.00627 ** NA
PDGFRB cabozantinib 0.0062762 0.3993414 0.00628 ** NA
BRAF trametinib 0.0064941 0.3993414 0.00649 ** NA
XPO1 nilotinib 0.0065876 0.3993414 0.00659 ** NA
HRAS pazopanib 0.0066082 0.3993414 0.00661 ** NA
PHF6 azd 0.0067277 0.3996689 0.00673 ** NA
VHL belinostat 0.0076395 0.4458479 0.00764 ** NA
NOTCH2 afatinib 0.0078494 0.4458479 0.00785 ** NA
DNMT3A gefitinib 0.0080435 0.4458479 0.00804 ** NA
SMC3 selumetinib 0.0080758 0.4458479 0.00808 ** NA
XPO1 cabozantinib 0.0081410 0.4458479 0.00814 ** NA
NOTCH1 cabozantinib 0.0084048 0.4532139 0.00840 ** NA
ERBB2 cyclophosphamide 0.0089622 0.4642665 0.00896 ** NA
CTCF cabozantinib 0.0089651 0.4642665 0.00897 ** NA
PIK3CA cabozantinib 0.0090072 0.4642665 0.00901 ** NA
FANCL cabozantinib 0.0094404 0.4795429 0.00944 ** NA
VHL regorafenib 0.0096726 0.4840337 0.00967 ** NA
KRAS regorafenib 0.0098050 0.4840337 0.00980 ** NA
ERBB2 cabozantinib 0.0100336 0.4884423 0.01003
NA
KRAS afatinib 0.0107829 0.5155815 0.01078
NA
ERBB4 vemurafenib 0.0111572 0.5155815 0.01116
NA
PML crizotinib 0.0111785 0.5155815 0.01118
NA
PIK3CA dasatinib 0.0112867 0.5155815 0.01129
NA
CEBPA cabozantinib 0.0113266 0.5155815 0.01133
NA
RIT1 dasatinib 0.0115989 0.5182474 0.01160
NA
KRAS vemurafenib 0.0119766 0.5182474 0.01198
NA
SMO crizotinib 0.0120777 0.5182474 0.01208
NA
PTEN fluorouracil 0.0121037 0.5182474 0.01210
NA
PAX8 cabozantinib 0.0122390 0.5182474 0.01224
NA
MYD88 vandetanib 0.0123446 0.5182474 0.01234
NA
KRAS azd 0.0127676 0.5182474 0.01277
NA
CREBBP vandetanib 0.0128028 0.5182474 0.01280
NA
ERBB3 cabozantinib 0.0128369 0.5182474 0.01284
NA
RAD21 vemurafenib 0.0129631 0.5182474 0.01296
NA
EML4 fulvestrant 0.0130188 0.5182474 0.01302
NA
FLCN cabozantinib 0.0131617 0.5182474 0.01316
NA
PTEN nilotinib 0.0133073 0.5182474 0.01331
NA
BRAF temozolomide 0.0137195 0.5284257 0.01372
NA
KIT ibrutinib 0.0142737 0.5316037 0.01427
NA
ATM temozolomide 0.0145671 0.5316037 0.01457
NA
NOTCH2 ibrutinib 0.0147581 0.5316037 0.01476
NA
TPMT sunitinib 0.0149004 0.5316037 0.01490
NA
HRAS belinostat 0.0149411 0.5316037 0.01494
NA
DNMT3A afatinib 0.0149999 0.5316037 0.01500
NA
BCORL1 imatinib 0.0150008 0.5316037 0.01500
NA
CEBPA sunitinib 0.0150153 0.5316037 0.01502
NA
PIGA imatinib 0.0153322 0.5337355 0.01533
NA
PML fluorouracil 0.0155734 0.5337355 0.01557
NA
RET azd 0.0156276 0.5337355 0.01563
NA
CDC73 nilotinib 0.0157781 0.5337355 0.01578
NA
PTCH1 trametinib 0.0159153 0.5337355 0.01592
NA
EGF imatinib 0.0160677 0.5337355 0.01607
NA
ROS1 pazopanib 0.0165094 0.5337355 0.01651
NA
PDGFB regorafenib 0.0165670 0.5337355 0.01657
NA
CYP19A1 regorafenib 0.0166069 0.5337355 0.01661
NA
GNAS cabozantinib 0.0166176 0.5337355 0.01662
NA
VHL cabozantinib 0.0168908 0.5337355 0.01689
NA
DNAJB1 dasatinib 0.0172411 0.5337355 0.01724
NA
HRAS ibrutinib 0.0172441 0.5337355 0.01724
NA
GATA2 olaparib 0.0172643 0.5337355 0.01726
NA
TP53 azd 0.0173597 0.5337355 0.01736
NA
UGT1A1 azd 0.0180042 0.5387827 0.01800
NA
STAG2 neratinib 0.0181489 0.5387827 0.01815
NA
DNAJB1 neratinib 0.0182441 0.5387827 0.01824
NA
JAK1 dasatinib 0.0182579 0.5387827 0.01826
NA
HRAS ruxolitinib 0.0183784 0.5387827 0.01838
NA
CDK6 selumetinib 0.0186672 0.5387827 0.01867
NA
BCORL1 vemurafenib 0.0187277 0.5387827 0.01873
NA
SMO selumetinib 0.0187536 0.5387827 0.01875
NA
MDM2 cabozantinib 0.0190791 0.5426815 0.01908
NA
HRAS crizotinib 0.0192255 0.5426815 0.01923
NA
JAK3 ibrutinib 0.0193538 0.5426815 0.01935
NA
MPL crizotinib 0.0200362 0.5517127 0.02004
NA
PTEN vandetanib 0.0203414 0.5517127 0.02034
NA
NRAS selumetinib 0.0204159 0.5517127 0.02042
NA
PTEN pazopanib 0.0204199 0.5517127 0.02042
NA
PDCD1 dasatinib 0.0204630 0.5517127 0.02046
NA
JAK3 gefitinib 0.0210547 0.5633346 0.02105
NA
SF3B1 temozolomide 0.0216735 0.5646563 0.02167
NA
BCOR regorafenib 0.0216994 0.5646563 0.02170
NA
CTLA4 erlotinib 0.0217734 0.5646563 0.02177
NA
SMO azd 0.0219539 0.5646563 0.02195
NA
BRAF cyclophosphamide 0.0222337 0.5646563 0.02223
NA
NRAS vandetanib 0.0222810 0.5646563 0.02228
NA
HRAS cabozantinib 0.0226792 0.5646563 0.02268
NA
SMO dasatinib 0.0227029 0.5646563 0.02270
NA
FBXW7 selumetinib 0.0228040 0.5646563 0.02280
NA
PRPF40B afatinib 0.0230376 0.5646563 0.02304
NA
ALK neratinib 0.0230681 0.5646563 0.02307
NA
PTEN crizotinib 0.0231108 0.5646563 0.02311
NA
DNMT3A trametinib 0.0232930 0.5646563 0.02329
NA
NRAS erlotinib 0.0233595 0.5646563 0.02336
NA
PHF6 dasatinib 0.0240009 0.5705146 0.02400
NA
CTLA4 gefitinib 0.0240362 0.5705146 0.02404
NA
MPL pazopanib 0.0241053 0.5705146 0.02411
NA
FGFR1 dabrafenib 0.0242530 0.5705146 0.02425
NA
ESR1 imatinib 0.0245120 0.5727630 0.02451
NA
CTLA4 lapatinib 0.0249688 0.5795745 0.02497
NA
VHL pazopanib 0.0252851 0.5830554 0.02529
NA
CDC73 regorafenib 0.0254828 0.5837727 0.02548
NA
ZRSR2 cabozantinib 0.0257289 0.5855820 0.02573
NA
RUNX1 cabozantinib 0.0262773 0.5934298 0.02628
NA
PAX8 nilotinib 0.0264123 0.5934298 0.02641
NA
BRCA1 fulvestrant 0.0266668 0.5953326 0.02667
NA
JAK2 temozolomide 0.0271063 0.5981327 0.02711
NA
JAK3 neratinib 0.0274252 0.5981327 0.02743
NA
CDC73 vemurafenib 0.0274453 0.5981327 0.02745
NA
SF3B1 pazopanib 0.0274831 0.5981327 0.02748
NA
DNMT3A crizotinib 0.0276455 0.5981327 0.02765
NA
TET2 gefitinib 0.0285365 0.6136220 0.02854
NA
FBXW7 erlotinib 0.0290920 0.6188596 0.02909
NA
RPL10 vemurafenib 0.0291978 0.6188596 0.02920
NA
PIK3CA dabrafenib 0.0293098 0.6188596 0.02931
NA
BRAF dasatinib 0.0300319 0.6288704 0.03003
NA
PHF6 cabozantinib 0.0304007 0.6288704 0.03040
NA
EML4 temozolomide 0.0304800 0.6288704 0.03048
NA
BRAF lapatinib 0.0305016 0.6288704 0.03050
NA
MAP2K1 dabrafenib 0.0309555 0.6320875 0.03096
NA
EGF erlotinib 0.0314188 0.6320875 0.03142
NA
PML selumetinib 0.0317252 0.6320875 0.03173
NA
CRLF2 neratinib 0.0323240 0.6320875 0.03232
NA
GNA11 ruxolitinib 0.0327779 0.6320875 0.03278
NA
PDGFRA ibrutinib 0.0333483 0.6320875 0.03335
NA
CTLA4 neratinib 0.0336983 0.6320875 0.03370
NA
CDKN2A olaparib 0.0337054 0.6320875 0.03371
NA
DNMT3A ibrutinib 0.0340522 0.6320875 0.03405
NA
UGT1A1 pazopanib 0.0341719 0.6320875 0.03417
NA
TSC2 vemurafenib 0.0345796 0.6320875 0.03458
NA
CDKN2A pazopanib 0.0349638 0.6320875 0.03496
NA
PRPF40B fulvestrant 0.0350898 0.6320875 0.03509
NA
DPYD selumetinib 0.0356352 0.6320875 0.03564
NA
DNMT3A neratinib 0.0356380 0.6320875 0.03564
NA
PIGA fulvestrant 0.0357583 0.6320875 0.03576
NA
SMC3 gefitinib 0.0358853 0.6320875 0.03589
NA
PHF6 vandetanib 0.0358904 0.6320875 0.03589
NA
AR belinostat 0.0359620 0.6320875 0.03596
NA
MET vemurafenib 0.0360691 0.6320875 0.03607
NA
KIT cabozantinib 0.0362427 0.6320875 0.03624
NA
PTEN temozolomide 0.0366028 0.6320875 0.03660
NA
PDGFRB afatinib 0.0366997 0.6320875 0.03670
NA
PIK3CA erlotinib 0.0371212 0.6320875 0.03712
NA
BCOR ruxolitinib 0.0371517 0.6320875 0.03715
NA
FBXW7 neratinib 0.0372624 0.6320875 0.03726
NA
NT5C2 nilotinib 0.0376566 0.6320875 0.03766
NA
TET2 regorafenib 0.0379740 0.6320875 0.03797
NA
ROS1 gefitinib 0.0380067 0.6320875 0.03801
NA
TPMT selumetinib 0.0382776 0.6320875 0.03828
NA
TSC2 cabozantinib 0.0383320 0.6320875 0.03833
NA
VHL azd 0.0384356 0.6320875 0.03844
NA
PTPN11 selumetinib 0.0388001 0.6320875 0.03880
NA
PIGA pazopanib 0.0390453 0.6320875 0.03905
NA
ROS1 cabozantinib 0.0390533 0.6320875 0.03905
NA
MYCN azd 0.0391289 0.6320875 0.03913
NA
MYCN neratinib 0.0391545 0.6320875 0.03915
NA
CBL dabrafenib 0.0392087 0.6320875 0.03921
NA
EGF dasatinib 0.0392917 0.6320875 0.03929
NA
BRAF fluorouracil 0.0393299 0.6320875 0.03933
NA
ASXL1 temozolomide 0.0395183 0.6320875 0.03952
NA
PHF6 ibrutinib 0.0395194 0.6320875 0.03952
NA
PRPF40B olaparib 0.0395265 0.6320875 0.03953
NA
CXCR4 pazopanib 0.0395940 0.6320875 0.03959
NA
KIT afatinib 0.0398249 0.6320875 0.03982
NA
NRAS belinostat 0.0399072 0.6320875 0.03991
NA
PRPF8 nilotinib 0.0400544 0.6320875 0.04005
NA
BCOR dabrafenib 0.0401328 0.6320875 0.04013
NA
HRAS lapatinib 0.0405701 0.6320875 0.04057
NA
CTCF vemurafenib 0.0408744 0.6320875 0.04087
NA
FLT3 cabozantinib 0.0412322 0.6320875 0.04123
NA
MET sunitinib 0.0414057 0.6320875 0.04141
NA
TP53 sunitinib 0.0414916 0.6320875 0.04149
NA
CBL pazopanib 0.0415646 0.6320875 0.04156
NA
BRAF azd 0.0415725 0.6320875 0.04157
NA
VHL olaparib 0.0419848 0.6320875 0.04198
NA
PTEN imatinib 0.0421067 0.6320875 0.04211
NA
VHL crizotinib 0.0421297 0.6320875 0.04213
NA
EZH2 dabrafenib 0.0423964 0.6320875 0.04240
NA
TP53 temozolomide 0.0424331 0.6320875 0.04243
NA
IL7R neratinib 0.0424641 0.6320875 0.04246
NA
DNMT3A erlotinib 0.0426319 0.6320875 0.04263
NA
WHSC1 trametinib 0.0427866 0.6320875 0.04279
NA
SMO vemurafenib 0.0429379 0.6320875 0.04294
NA
CYP19A1 imatinib 0.0430959 0.6320875 0.04310
NA
PTEN erlotinib 0.0432137 0.6320875 0.04321
NA
CBL cabozantinib 0.0433410 0.6320875 0.04334
NA
FLT3 olaparib 0.0434999 0.6320875 0.04350
NA
IKZF1 dasatinib 0.0435525 0.6320875 0.04355
NA
MET crizotinib 0.0436200 0.6320875 0.04362
NA
WT1 neratinib 0.0437295 0.6320875 0.04373
NA
PTEN regorafenib 0.0437414 0.6320875 0.04374
NA
FLCN vemurafenib 0.0441692 0.6320875 0.04417
NA
PIGA crizotinib 0.0446094 0.6320875 0.04461
NA
CRLF2 fluorouracil 0.0446618 0.6320875 0.04466
NA
AKT2 imatinib 0.0447614 0.6320875 0.04476
NA
ROS1 azd 0.0447795 0.6320875 0.04478
NA
CTCF nilotinib 0.0447893 0.6320875 0.04479
NA
PTEN selumetinib 0.0449044 0.6320875 0.04490
NA
SMC3 erlotinib 0.0455886 0.6341430 0.04559
NA
CEBPA imatinib 0.0455890 0.6341430 0.04559
NA
CTCF dasatinib 0.0456479 0.6341430 0.04565
NA
ROS1 olaparib 0.0457741 0.6341430 0.04577
NA
WHSC1 selumetinib 0.0468008 0.6401197 0.04680
NA
GNA11 trametinib 0.0468157 0.6401197 0.04682
NA
AKT2 vemurafenib 0.0468663 0.6401197 0.04687
NA
CRLF2 afatinib 0.0469360 0.6401197 0.04694
NA
MAP2K2 dabrafenib 0.0485597 0.6506653 0.04856
NA
TSC1 nilotinib 0.0489600 0.6506653 0.04896
NA
RPL10 imatinib 0.0490026 0.6506653 0.04900
NA
NT5C2 lapatinib 0.0490205 0.6506653 0.04902
NA
MDM2 temozolomide 0.0490362 0.6506653 0.04904
NA
FANCL regorafenib 0.0492450 0.6506653 0.04924
NA
KMT2A vemurafenib 0.0492856 0.6506653 0.04929
NA
BRCA1 belinostat 0.0497327 0.6506653 0.04973
NA
PIGA azd 0.0499171 0.6506653 0.04992
NA
XPO1 regorafenib 0.0499890 0.6506653 0.04999
NA
PDGFRB regorafenib 0.0500392 0.6506653 0.05004 NA NA
ALK dasatinib 0.0501428 0.6506653 0.05014 NA NA
PIK3CA sunitinib 0.0503301 0.6506653 0.05033 NA NA
MET selumetinib 0.0507587 0.6506653 0.05076 NA NA
KRAS crizotinib 0.0508005 0.6506653 0.05080 NA NA
NOTCH2 fulvestrant 0.0519985 0.6506653 0.05200 NA NA
PAX5 cabozantinib 0.0520777 0.6506653 0.05208 NA NA
PHF6 nilotinib 0.0521758 0.6506653 0.05218 NA NA
PTCH1 regorafenib 0.0522146 0.6506653 0.05221 NA NA
VHL sunitinib 0.0523565 0.6506653 0.05236 NA NA
MAP2K2 afatinib 0.0523654 0.6506653 0.05237 NA NA
GNAQ gefitinib 0.0524208 0.6506653 0.05242 NA NA
PTCH1 vemurafenib 0.0527029 0.6506653 0.05270 NA NA
CDC73 cabozantinib 0.0528058 0.6506653 0.05281 NA NA
RET selumetinib 0.0529915 0.6506653 0.05299 NA NA
BRCA1 vemurafenib 0.0531252 0.6506653 0.05313 NA NA
ALK vandetanib 0.0531880 0.6506653 0.05319 NA NA
XPO1 vemurafenib 0.0534441 0.6506653 0.05344 NA NA
RUNX1 vemurafenib 0.0536122 0.6506653 0.05361 NA NA
PDGFRA gefitinib 0.0538638 0.6506653 0.05386 NA NA
CTLA4 vandetanib 0.0539976 0.6506653 0.05400 NA NA
NCOA2 lapatinib 0.0541227 0.6506653 0.05412 NA NA
WHSC1 ruxolitinib 0.0541464 0.6506653 0.05415 NA NA
RUNX1 ibrutinib 0.0541729 0.6506653 0.05417 NA NA
FGFR3 trametinib 0.0542066 0.6506653 0.05421 NA NA
DNAJB1 olaparib 0.0546041 0.6520244 0.05460 NA NA
GNAQ imatinib 0.0546919 0.6520244 0.05469 NA NA
MET nilotinib 0.0553000 0.6554101 0.05530 NA NA
CD79B ibrutinib 0.0553499 0.6554101 0.05535 NA NA
JAK2 nilotinib 0.0558396 0.6589824 0.05584 NA NA
SMO vandetanib 0.0561251 0.6599344 0.05613 NA NA
TPMT imatinib 0.0564058 0.6599344 0.05641 NA NA
NT5C2 neratinib 0.0564851 0.6599344 0.05649 NA NA
BRCA2 temozolomide 0.0567584 0.6605021 0.05676 NA NA
U2AF1 lapatinib 0.0573937 0.6605021 0.05739 NA NA
MYD88 temozolomide 0.0574402 0.6605021 0.05744 NA NA
NPM1 lapatinib 0.0576027 0.6605021 0.05760 NA NA
RIT1 neratinib 0.0576777 0.6605021 0.05768 NA NA
NCOA2 neratinib 0.0577406 0.6605021 0.05774 NA NA
MGMT dabrafenib 0.0578528 0.6605021 0.05785 NA NA
IDH2 olaparib 0.0581368 0.6615887 0.05814 NA NA
NCOA2 vemurafenib 0.0586660 0.6632341 0.05867 NA NA
PTCH1 temozolomide 0.0588364 0.6632341 0.05884 NA NA
HRAS vandetanib 0.0589220 0.6632341 0.05892 NA NA
ALK crizotinib 0.0595488 0.6632341 0.05955 NA NA
CBLB dabrafenib 0.0596936 0.6632341 0.05969 NA NA
GATA3 fluorouracil 0.0598679 0.6632341 0.05987 NA NA
JAK3 dabrafenib 0.0601470 0.6632341 0.06015 NA NA
JAK2 cabozantinib 0.0601835 0.6632341 0.06018 NA NA
CD274 nilotinib 0.0604135 0.6632341 0.06041 NA NA
EZH2 belinostat 0.0605653 0.6632341 0.06057 NA NA
PIK3CA fluorouracil 0.0606871 0.6632341 0.06069 NA NA
ABL1 cyclophosphamide 0.0608027 0.6632341 0.06080 NA NA
PDGFRB sunitinib 0.0609026 0.6632341 0.06090 NA NA
GATA3 temozolomide 0.0609305 0.6632341 0.06093 NA NA
VHL fluorouracil 0.0611560 0.6636274 0.06116 NA NA
DNAJB1 trametinib 0.0614179 0.6636970 0.06142 NA NA
PTCH1 imatinib 0.0615411 0.6636970 0.06154 NA NA
DPYD neratinib 0.0622681 0.6672391 0.06227 NA NA
PDGFRA lapatinib 0.0624698 0.6672391 0.06247 NA NA
PTCH1 erlotinib 0.0624883 0.6672391 0.06249 NA NA
EGF gefitinib 0.0626864 0.6672391 0.06269 NA NA
MET cabozantinib 0.0628214 0.6672391 0.06282 NA NA
EGF afatinib 0.0638562 0.6725304 0.06386 NA NA
CYP19A1 dasatinib 0.0644360 0.6725304 0.06444 NA NA
FGFR1 cyclophosphamide 0.0645668 0.6725304 0.06457 NA NA
AKT3 dasatinib 0.0647027 0.6725304 0.06470 NA NA
AR cabozantinib 0.0650406 0.6725304 0.06504 NA NA
SMC1A cyclophosphamide 0.0651050 0.6725304 0.06511 NA NA
EZH2 crizotinib 0.0651601 0.6725304 0.06516 NA NA
PTCH1 sunitinib 0.0653514 0.6725304 0.06535 NA NA
TP53 fluorouracil 0.0659191 0.6725304 0.06592 NA NA
UGT1A1 cabozantinib 0.0659861 0.6725304 0.06599 NA NA
STAT3 dasatinib 0.0662264 0.6725304 0.06623 NA NA
SRSF2 neratinib 0.0664900 0.6725304 0.06649 NA NA
ERBB2 fulvestrant 0.0667862 0.6725304 0.06679 NA NA
SSX1 temozolomide 0.0670487 0.6725304 0.06705 NA NA
AKT1 cabozantinib 0.0671417 0.6725304 0.06714 NA NA
DNMT3A sunitinib 0.0672906 0.6725304 0.06729 NA NA
EGFR regorafenib 0.0674563 0.6725304 0.06746 NA NA
MPL gefitinib 0.0678851 0.6725304 0.06789 NA NA
CALR dabrafenib 0.0679741 0.6725304 0.06797 NA NA
CTLA4 temozolomide 0.0680635 0.6725304 0.06806 NA NA
ROS1 crizotinib 0.0682314 0.6725304 0.06823 NA NA
MET gefitinib 0.0682941 0.6725304 0.06829 NA NA
NOTCH2 trametinib 0.0686269 0.6725304 0.06863 NA NA
ROS1 erlotinib 0.0687863 0.6725304 0.06879 NA NA
FBXW7 temozolomide 0.0689091 0.6725304 0.06891 NA NA
CTLA4 regorafenib 0.0689931 0.6725304 0.06899 NA NA
GATA1 regorafenib 0.0690666 0.6725304 0.06907 NA NA
JAK2 erlotinib 0.0694206 0.6725304 0.06942 NA NA
JAK2 gefitinib 0.0695010 0.6725304 0.06950 NA NA
PTEN ibrutinib 0.0695343 0.6725304 0.06953 NA NA
MAP2K2 fulvestrant 0.0695606 0.6725304 0.06956 NA NA
KRAS ruxolitinib 0.0698118 0.6725304 0.06981 NA NA
GATA2 ruxolitinib 0.0699082 0.6725304 0.06991 NA NA
KRAS nilotinib 0.0700538 0.6725304 0.07005 NA NA
FGFR1 vandetanib 0.0700597 0.6725304 0.07006 NA NA
RAD21 dabrafenib 0.0703494 0.6725304 0.07035 NA NA
U2AF1 regorafenib 0.0704190 0.6725304 0.07042 NA NA
PAX8 imatinib 0.0710267 0.6728311 0.07103 NA NA
TPMT afatinib 0.0710783 0.6728311 0.07108 NA NA
CTNNB1 regorafenib 0.0711165 0.6728311 0.07112 NA NA
DPYD azd 0.0712184 0.6728311 0.07122 NA NA
MAP2K1 regorafenib 0.0717891 0.6764000 0.07179 NA NA
CD274 sunitinib 0.0724713 0.6766861 0.07247 NA NA
ALK afatinib 0.0725102 0.6766861 0.07251 NA NA
MAP2K2 gefitinib 0.0725157 0.6766861 0.07252 NA NA
CEBPA crizotinib 0.0725917 0.6766861 0.07259 NA NA
EML4 trametinib 0.0732986 0.6801743 0.07330 NA NA
SMO nilotinib 0.0734446 0.6801743 0.07344 NA NA
PDGFRA vemurafenib 0.0735826 0.6801743 0.07358 NA NA
PTEN cabozantinib 0.0738681 0.6801743 0.07387 NA NA
G6PD regorafenib 0.0740828 0.6801743 0.07408 NA NA
MPL imatinib 0.0742277 0.6801743 0.07423 NA NA
KIT selumetinib 0.0746874 0.6801743 0.07469 NA NA
CTCF fluorouracil 0.0748081 0.6801743 0.07481 NA NA
CDK6 imatinib 0.0748933 0.6801743 0.07489 NA NA
NPM1 pazopanib 0.0750765 0.6801743 0.07508 NA NA
TPMT cabozantinib 0.0751475 0.6801743 0.07515 NA NA
FLCN olaparib 0.0752946 0.6801743 0.07529 NA NA
CXCR4 vemurafenib 0.0758761 0.6829912 0.07588 NA NA
TSC1 vemurafenib 0.0759962 0.6829912 0.07600 NA NA
PIK3CA ibrutinib 0.0765203 0.6859432 0.07652 NA NA
SSX1 gefitinib 0.0767754 0.6861057 0.07678 NA NA
GNAS lapatinib 0.0769300 0.6861057 0.07693 NA NA
JAK1 vemurafenib 0.0784429 0.6967987 0.07844 NA NA
MYCN lapatinib 0.0785265 0.6967987 0.07853 NA NA
PML vemurafenib 0.0789218 0.6979744 0.07892 NA NA
SRSF2 olaparib 0.0791994 0.6979744 0.07920 NA NA
KMT2A cabozantinib 0.0793512 0.6979744 0.07935 NA NA
TSC1 fluorouracil 0.0794633 0.6979744 0.07946 NA NA
PTPN11 gefitinib 0.0796547 0.6979744 0.07965 NA NA
UGT1A1 sunitinib 0.0800633 0.6998049 0.08006 NA NA
DNMT3A fluorouracil 0.0810167 0.7063768 0.08102 NA NA
G6PD nilotinib 0.0817599 0.7079988 0.08176 NA NA
FBXW7 vandetanib 0.0818241 0.7079988 0.08182 NA NA
PDGFRA erlotinib 0.0818940 0.7079988 0.08189 NA NA
CD79B cabozantinib 0.0821957 0.7079988 0.08220 NA NA
ERBB2 dabrafenib 0.0822127 0.7079988 0.08221 NA NA
RET afatinib 0.0832455 0.7126256 0.08325 NA NA
MDM2 sunitinib 0.0835956 0.7126256 0.08360 NA NA
CDKN2A crizotinib 0.0836611 0.7126256 0.08366 NA NA
PDGFRB trametinib 0.0837396 0.7126256 0.08374 NA NA
BRCA2 vemurafenib 0.0837665 0.7126256 0.08377 NA NA
MYD88 nilotinib 0.0840035 0.7129111 0.08400 NA NA
CDKN2A sunitinib 0.0845214 0.7155738 0.08452 NA NA
PIGA regorafenib 0.0851757 0.7161199 0.08518 NA NA
STAT3 erlotinib 0.0853030 0.7161199 0.08530 NA NA
FLCN fluorouracil 0.0853732 0.7161199 0.08537 NA NA
CREBBP sunitinib 0.0855553 0.7161199 0.08556 NA NA
HRAS dasatinib 0.0856075 0.7161199 0.08561 NA NA
SETD2 fluorouracil 0.0859390 0.7171812 0.08594 NA NA
RPL10 vandetanib 0.0862184 0.7178040 0.08622 NA NA
JAK1 cabozantinib 0.0867994 0.7202102 0.08680 NA NA
WHSC1 imatinib 0.0870643 0.7202102 0.08706 NA NA
BRCA1 azd 0.0871239 0.7202102 0.08712 NA NA
CDC73 temozolomide 0.0876395 0.7227684 0.08764 NA NA
GATA2 imatinib 0.0881485 0.7252593 0.08815 NA NA
ERBB4 olaparib 0.0888830 0.7277387 0.08888 NA NA
TPMT crizotinib 0.0889926 0.7277387 0.08899 NA NA
PRPF8 vemurafenib 0.0891286 0.7277387 0.08913 NA NA
KIT trametinib 0.0892804 0.7277387 0.08928 NA NA
GATA1 dabrafenib 0.0898472 0.7304655 0.08985 NA NA
PIGA cabozantinib 0.0902445 0.7304655 0.09024 NA NA
MPL sunitinib 0.0903895 0.7304655 0.09039 NA NA
RET fluorouracil 0.0904485 0.7304655 0.09045 NA NA
PIK3CA vemurafenib 0.0908048 0.7305190 0.09080 NA NA
CTLA4 cabozantinib 0.0908924 0.7305190 0.09089 NA NA
EML4 ibrutinib 0.0917280 0.7305190 0.09173 NA NA
NOTCH2 vandetanib 0.0917596 0.7305190 0.09176 NA NA
SMO neratinib 0.0919955 0.7305190 0.09200 NA NA
ERBB4 temozolomide 0.0921082 0.7305190 0.09211 NA NA
SMC1A dasatinib 0.0921852 0.7305190 0.09219 NA NA
BCOR trametinib 0.0923148 0.7305190 0.09231 NA NA
BRCA2 pazopanib 0.0923309 0.7305190 0.09233 NA NA
TPMT dasatinib 0.0925509 0.7306098 0.09255 NA NA
ROS1 nilotinib 0.0927972 0.7309081 0.09280 NA NA
STAG2 olaparib 0.0932183 0.7323869 0.09322 NA NA
PDGFRA temozolomide 0.0937160 0.7323869 0.09372 NA NA
SRSF2 afatinib 0.0937442 0.7323869 0.09374 NA NA
TET2 nilotinib 0.0938208 0.7323869 0.09382 NA NA
FBXW7 olaparib 0.0940419 0.7324818 0.09404 NA NA
G6PD dabrafenib 0.0952173 0.7399928 0.09522 NA NA
NRAS trametinib 0.0961814 0.7418025 0.09618 NA NA
EGF regorafenib 0.0962004 0.7418025 0.09620 NA NA
ERBB4 crizotinib 0.0965888 0.7418025 0.09659 NA NA
CDKN2A ruxolitinib 0.0966854 0.7418025 0.09669 NA NA
RET cyclophosphamide 0.0968718 0.7418025 0.09687 NA NA
CD274 ruxolitinib 0.0972548 0.7418025 0.09725 NA NA
CTCF erlotinib 0.0973786 0.7418025 0.09738 NA NA
MAP2K2 vandetanib 0.0974409 0.7418025 0.09744 NA NA
STAG2 regorafenib 0.0976712 0.7418025 0.09767 NA NA
FGFR3 imatinib 0.0977628 0.7418025 0.09776 NA NA
PDCD1 vemurafenib 0.0977783 0.7418025 0.09778 NA NA
GATA3 sunitinib 0.0981168 0.7427632 0.09812 NA NA
DNAJB1 afatinib 0.0985287 0.7442737 0.09853 NA NA
PTEN dabrafenib 0.0990454 0.7465681 0.09905 NA NA
DNMT3A olaparib 0.0996068 0.7480260 0.09961 NA NA
RPL10 temozolomide 0.0996657 0.7480260 0.09967 NA NA
CDK4 dabrafenib 0.1007756 0.7541059 0.10078 NA NA
PIK3CA crizotinib 0.1009281 0.7541059 0.10093 NA NA
BCOR temozolomide 0.1011212 0.7541059 0.10112 NA NA
XPO1 temozolomide 0.1017504 0.7571871 0.10175 NA NA
SF1 cabozantinib 0.1022414 0.7581569 0.10224 NA NA
PIGA sunitinib 0.1023133 0.7581569 0.10231 NA NA
NOTCH2 temozolomide 0.1032821 0.7599893 0.10328 NA NA
NT5C2 fluorouracil 0.1033367 0.7599893 0.10334 NA NA
DPYD afatinib 0.1034804 0.7599893 0.10348 NA NA
ABL1 trametinib 0.1038508 0.7599893 0.10385 NA NA
HRAS azd 0.1038879 0.7599893 0.10389 NA NA
WHSC1 cabozantinib 0.1045013 0.7599893 0.10450 NA NA
JAK3 vandetanib 0.1045969 0.7599893 0.10460 NA NA
MGMT imatinib 0.1047274 0.7599893 0.10473 NA NA
PHF6 sunitinib 0.1049670 0.7599893 0.10497 NA NA
DPYD vandetanib 0.1050806 0.7599893 0.10508 NA NA
EZH2 sunitinib 0.1053449 0.7599893 0.10534 NA NA
CDK4 trametinib 0.1055733 0.7599893 0.10557 NA NA
SRSF2 vandetanib 0.1055742 0.7599893 0.10557 NA NA
SF1 vemurafenib 0.1055962 0.7599893 0.10560 NA NA
CXCR4 neratinib 0.1062246 0.7608291 0.10622 NA NA
GNA11 fulvestrant 0.1064421 0.7608291 0.10644 NA NA
CXCR4 azd 0.1065396 0.7608291 0.10654 NA NA
NOTCH1 fulvestrant 0.1070302 0.7608291 0.10703 NA NA
STAT3 imatinib 0.1071208 0.7608291 0.10712 NA NA
AR trametinib 0.1075006 0.7608291 0.10750 NA NA
ATM ruxolitinib 0.1077925 0.7608291 0.10779 NA NA
CDK4 azd 0.1079284 0.7608291 0.10793 NA NA
WHSC1 sunitinib 0.1079484 0.7608291 0.10795 NA NA
FGFR1 sunitinib 0.1079957 0.7608291 0.10800 NA NA
PTEN belinostat 0.1081007 0.7608291 0.10810 NA NA
AKT3 vemurafenib 0.1087395 0.7627504 0.10874 NA NA
PDGFB ibrutinib 0.1088089 0.7627504 0.10881 NA NA
MGMT erlotinib 0.1093037 0.7637859 0.10930 NA NA
AKT1 crizotinib 0.1095589 0.7637859 0.10956 NA NA
PRPF40B imatinib 0.1098756 0.7637859 0.10988 NA NA
TP53 fulvestrant 0.1099325 0.7637859 0.10993 NA NA
NCOA2 sunitinib 0.1100462 0.7637859 0.11005 NA NA
DNAJB1 cabozantinib 0.1109801 0.7687458 0.11098 NA NA
DNAJB1 pazopanib 0.1112445 0.7690568 0.11124 NA NA
RUNX1 temozolomide 0.1120087 0.7693865 0.11201 NA NA
AKT1 azd 0.1125486 0.7693865 0.11255 NA NA
JAK1 imatinib 0.1127175 0.7693865 0.11272 NA NA
CBLB cabozantinib 0.1128859 0.7693865 0.11289 NA NA
RET trametinib 0.1129218 0.7693865 0.11292 NA NA
CTNNB1 ibrutinib 0.1129585 0.7693865 0.11296 NA NA
ATM cyclophosphamide 0.1129954 0.7693865 0.11300 NA NA
CREBBP erlotinib 0.1130482 0.7693865 0.11305 NA NA
XPO1 sunitinib 0.1137602 0.7727313 0.11376 NA NA
UGT1A1 dabrafenib 0.1142522 0.7745723 0.11425 NA NA
MDM2 trametinib 0.1144784 0.7746075 0.11448 NA NA
ESR1 fluorouracil 0.1147435 0.7749053 0.11474 NA NA
DNMT3A pazopanib 0.1153640 0.7754314 0.11536 NA NA
GNAQ cabozantinib 0.1156745 0.7754314 0.11567 NA NA
AKT2 regorafenib 0.1158322 0.7754314 0.11583 NA NA
FANCL ruxolitinib 0.1160798 0.7754314 0.11608 NA NA
PDGFB vemurafenib 0.1163543 0.7754314 0.11635 NA NA
GNAQ lapatinib 0.1165022 0.7754314 0.11650 NA NA
SF3B1 selumetinib 0.1165553 0.7754314 0.11656 NA NA
PTCH1 lapatinib 0.1167103 0.7754314 0.11671 NA NA
PTPN11 azd 0.1170068 0.7754314 0.11701 NA NA
PRPF40B nilotinib 0.1174956 0.7754314 0.11750 NA NA
EGF olaparib 0.1175606 0.7754314 0.11756 NA NA
BCORL1 cabozantinib 0.1177980 0.7754314 0.11780 NA NA
RIT1 fulvestrant 0.1178308 0.7754314 0.11783 NA NA
CALR nilotinib 0.1179187 0.7754314 0.11792 NA NA
DNAJB1 ruxolitinib 0.1183390 0.7758904 0.11834 NA NA
IL7R trametinib 0.1184312 0.7758904 0.11843 NA NA
FLCN gefitinib 0.1191367 0.7778584 0.11914 NA NA
PRPF40B vandetanib 0.1193475 0.7778584 0.11935 NA NA
CALR cabozantinib 0.1193974 0.7778584 0.11940 NA NA
AKT1 sunitinib 0.1198936 0.7786776 0.11989 NA NA
CSF3R ibrutinib 0.1199675 0.7786776 0.11997 NA NA
RIT1 ruxolitinib 0.1202230 0.7788938 0.12022 NA NA
CALR gefitinib 0.1208131 0.7802932 0.12081 NA NA
PDGFRA azd 0.1211302 0.7802932 0.12113 NA NA
PTPN11 dabrafenib 0.1213506 0.7802932 0.12135 NA NA
FLCN imatinib 0.1214437 0.7802932 0.12144 NA NA
CDKN2A imatinib 0.1217181 0.7802932 0.12172 NA NA
FLCN fulvestrant 0.1219799 0.7802932 0.12198 NA NA
SMO fluorouracil 0.1219973 0.7802932 0.12200 NA NA
DNAJB1 erlotinib 0.1232005 0.7865533 0.12320 NA NA
HRAS olaparib 0.1237067 0.7870376 0.12371 NA NA
ASXL1 selumetinib 0.1239994 0.7870376 0.12400 NA NA
BRCA1 nilotinib 0.1242641 0.7870376 0.12426 NA NA
PTPN11 erlotinib 0.1243777 0.7870376 0.12438 NA NA
TPMT neratinib 0.1244008 0.7870376 0.12440 NA NA
IDH1 selumetinib 0.1247711 0.7870376 0.12477 NA NA
TSC1 cabozantinib 0.1252422 0.7870376 0.12524 NA NA
FBXW7 gefitinib 0.1252959 0.7870376 0.12530 NA NA
RUNX1 trametinib 0.1255265 0.7870376 0.12553 NA NA
PML gefitinib 0.1255530 0.7870376 0.12555 NA NA
ERBB2 fluorouracil 0.1257464 0.7870376 0.12575 NA NA
AKT3 nilotinib 0.1260754 0.7873526 0.12608 NA NA
MYCN trametinib 0.1265565 0.7873526 0.12656 NA NA
CTNNB1 vemurafenib 0.1267129 0.7873526 0.12671 NA NA
TP53 nilotinib 0.1268691 0.7873526 0.12687 NA NA
CYP19A1 ibrutinib 0.1269984 0.7873526 0.12700 NA NA
CYP19A1 dabrafenib 0.1271974 0.7873526 0.12720 NA NA
ALK ibrutinib 0.1274241 0.7873526 0.12742 NA NA
PTCH1 nilotinib 0.1277181 0.7873526 0.12772 NA NA
GATA2 azd 0.1278184 0.7873526 0.12782 NA NA
SMC3 trametinib 0.1282147 0.7877273 0.12821 NA NA
PRPF40B cabozantinib 0.1285131 0.7877273 0.12851 NA NA
FGFR2 fulvestrant 0.1285535 0.7877273 0.12855 NA NA
VHL nilotinib 0.1289789 0.7889547 0.12898 NA NA
MAP2K2 trametinib 0.1303953 0.7962289 0.13040 NA NA
NPM1 erlotinib 0.1307567 0.7966577 0.13076 NA NA
MAP2K1 nilotinib 0.1312132 0.7966577 0.13121 NA NA
RIT1 imatinib 0.1313416 0.7966577 0.13134 NA NA
SMC1A gefitinib 0.1315843 0.7966577 0.13158 NA NA
EGFR trametinib 0.1316155 0.7966577 0.13162 NA NA
NPM1 sunitinib 0.1320366 0.7966577 0.13204 NA NA
NOTCH2 erlotinib 0.1320565 0.7966577 0.13206 NA NA
ROS1 regorafenib 0.1323222 0.7968891 0.13232 NA NA
NT5C2 afatinib 0.1326113 0.7972602 0.13261 NA NA
JAK2 vemurafenib 0.1329072 0.7976706 0.13291 NA NA
KMT2A nilotinib 0.1337835 0.7981820 0.13378 NA NA
PIGA lapatinib 0.1341049 0.7981820 0.13410 NA NA
MAP2K2 vemurafenib 0.1342462 0.7981820 0.13425 NA NA
PRPF40B sunitinib 0.1344950 0.7981820 0.13450 NA NA
GNAS nilotinib 0.1345771 0.7981820 0.13458 NA NA
RPL10 regorafenib 0.1349031 0.7981820 0.13490 NA NA
ERBB4 gefitinib 0.1349667 0.7981820 0.13497 NA NA
WHSC1 fluorouracil 0.1350066 0.7981820 0.13501 NA NA
BRAF imatinib 0.1350841 0.7981820 0.13508 NA NA
FGFR1 trametinib 0.1354219 0.7981820 0.13542 NA NA
NOTCH2 neratinib 0.1355982 0.7981820 0.13560 NA NA
TP53 dabrafenib 0.1357251 0.7981820 0.13573 NA NA
MAP2K1 belinostat 0.1362402 0.7998691 0.13624 NA NA
PAX8 ibrutinib 0.1366591 0.8009867 0.13666 NA NA
BRCA2 neratinib 0.1369451 0.8013229 0.13695 NA NA
PTCH1 olaparib 0.1376429 0.8028709 0.13764 NA NA
CXCR4 belinostat 0.1376677 0.8028709 0.13767 NA NA
NRAS imatinib 0.1384091 0.8045501 0.13841 NA NA
CREBBP nilotinib 0.1384148 0.8045501 0.13841 NA NA
CD79B dabrafenib 0.1390400 0.8059781 0.13904 NA NA
BCOR vemurafenib 0.1391467 0.8059781 0.13915 NA NA
SMC3 dasatinib 0.1393503 0.8059781 0.13935 NA NA
PRPF8 cabozantinib 0.1398247 0.8073895 0.13982 NA NA
PHF6 afatinib 0.1404522 0.8078863 0.14045 NA NA
CRLF2 crizotinib 0.1405708 0.8078863 0.14057 NA NA
PIGA vemurafenib 0.1406472 0.8078863 0.14065 NA NA
TPMT ruxolitinib 0.1408874 0.8078863 0.14089 NA NA
SF3B1 trametinib 0.1410632 0.8078863 0.14106 NA NA
SMC1A regorafenib 0.1419292 0.8098874 0.14193 NA NA
HRAS regorafenib 0.1421163 0.8098874 0.14212 NA NA
IDH1 lapatinib 0.1421804 0.8098874 0.14218 NA NA
UGT1A1 selumetinib 0.1423368 0.8098874 0.14234 NA NA
NOTCH1 sunitinib 0.1427914 0.8105372 0.14279 NA NA
BCORL1 trametinib 0.1429136 0.8105372 0.14291 NA NA
MGMT fluorouracil 0.1432551 0.8111616 0.14326 NA NA
PTPN11 imatinib 0.1438706 0.8133332 0.14387 NA NA
MAP2K2 fluorouracil 0.1451351 0.8139669 0.14514 NA NA
DNAJB1 lapatinib 0.1453252 0.8139669 0.14533 NA NA
BRCA2 erlotinib 0.1458082 0.8139669 0.14581 NA NA
PIGA nilotinib 0.1458103 0.8139669 0.14581 NA NA
ALK erlotinib 0.1462901 0.8139669 0.14629 NA NA
CDK4 ruxolitinib 0.1466623 0.8139669 0.14666 NA NA
CDC73 erlotinib 0.1471099 0.8139669 0.14711 NA NA
NRAS pazopanib 0.1471822 0.8139669 0.14718 NA NA
FLT3 nilotinib 0.1476259 0.8139669 0.14763 NA NA
SH2B3 azd 0.1476460 0.8139669 0.14765 NA NA
DPYD nilotinib 0.1476663 0.8139669 0.14767 NA NA
CXCR4 sunitinib 0.1478791 0.8139669 0.14788 NA NA
PRPF40B pazopanib 0.1481602 0.8139669 0.14816 NA NA
CTNNB1 azd 0.1486690 0.8139669 0.14867 NA NA
WT1 dabrafenib 0.1487594 0.8139669 0.14876 NA NA
SMC3 temozolomide 0.1491969 0.8139669 0.14920 NA NA
BCORL1 dabrafenib 0.1492104 0.8139669 0.14921 NA NA
FLCN temozolomide 0.1492541 0.8139669 0.14925 NA NA
GATA2 pazopanib 0.1494006 0.8139669 0.14940 NA NA
FBXW7 fulvestrant 0.1495816 0.8139669 0.14958 NA NA
PIK3CA regorafenib 0.1496344 0.8139669 0.14963 NA NA
G6PD trametinib 0.1496537 0.8139669 0.14965 NA NA
GATA2 temozolomide 0.1499759 0.8139669 0.14998 NA NA
CALR ruxolitinib 0.1502069 0.8139669 0.15021 NA NA
CTCF dabrafenib 0.1505836 0.8139669 0.15058 NA NA
NOTCH2 azd 0.1511979 0.8139669 0.15120 NA NA
GNAS imatinib 0.1513761 0.8139669 0.15138 NA NA
FBXW7 dasatinib 0.1515082 0.8139669 0.15151 NA NA
FGFR2 vandetanib 0.1516630 0.8139669 0.15166 NA NA
TSC1 sunitinib 0.1518085 0.8139669 0.15181 NA NA
RIT1 olaparib 0.1523414 0.8139669 0.15234 NA NA
ASXL1 cabozantinib 0.1523643 0.8139669 0.15236 NA NA
RIT1 vandetanib 0.1526440 0.8139669 0.15264 NA NA
PRPF8 regorafenib 0.1527561 0.8139669 0.15276 NA NA
AKT1 neratinib 0.1528627 0.8139669 0.15286 NA NA
DPYD fulvestrant 0.1532097 0.8139669 0.15321 NA NA
ERBB2 erlotinib 0.1533325 0.8139669 0.15333 NA NA
JAK3 imatinib 0.1536430 0.8139669 0.15364 NA NA
STAG2 pazopanib 0.1545538 0.8139669 0.15455 NA NA
AR ruxolitinib 0.1546453 0.8139669 0.15465 NA NA
CSF3R selumetinib 0.1547424 0.8139669 0.15474 NA NA
SH2B3 vandetanib 0.1547989 0.8139669 0.15480 NA NA
CDKN2A nilotinib 0.1548829 0.8139669 0.15488 NA NA
G6PD selumetinib 0.1551003 0.8139669 0.15510 NA NA
PAX8 temozolomide 0.1555864 0.8139669 0.15559 NA NA
PTPN11 vandetanib 0.1562055 0.8139669 0.15621 NA NA
PDGFRB selumetinib 0.1562725 0.8139669 0.15627 NA NA
SETD2 dasatinib 0.1567577 0.8139669 0.15676 NA NA
SF1 temozolomide 0.1568007 0.8139669 0.15680 NA NA
FBXW7 pazopanib 0.1570251 0.8139669 0.15703 NA NA
ALK azd 0.1572449 0.8139669 0.15724 NA NA
PAX8 belinostat 0.1576880 0.8139669 0.15769 NA NA
FLT3 vemurafenib 0.1577275 0.8139669 0.15773 NA NA
SRSF2 ibrutinib 0.1577676 0.8139669 0.15777 NA NA
NPM1 crizotinib 0.1583886 0.8139669 0.15839 NA NA
CYP19A1 fluorouracil 0.1588485 0.8139669 0.15885 NA NA
DNMT3A dasatinib 0.1589015 0.8139669 0.15890 NA NA
NCOA2 cabozantinib 0.1589077 0.8139669 0.15891 NA NA
CTLA4 vemurafenib 0.1591235 0.8139669 0.15912 NA NA
ALK selumetinib 0.1591782 0.8139669 0.15918 NA NA
MPL selumetinib 0.1593342 0.8139669 0.15933 NA NA
CDK4 regorafenib 0.1593708 0.8139669 0.15937 NA NA
FANCL sunitinib 0.1594357 0.8139669 0.15944 NA NA
JAK1 erlotinib 0.1595117 0.8139669 0.15951 NA NA
SETBP1 lapatinib 0.1597840 0.8139669 0.15978 NA NA
KIT erlotinib 0.1599953 0.8139669 0.16000 NA NA
ASXL1 fulvestrant 0.1600019 0.8139669 0.16000 NA NA
CYP19A1 belinostat 0.1605668 0.8139669 0.16057 NA NA
UGT1A1 olaparib 0.1608514 0.8139669 0.16085 NA NA
IL7R selumetinib 0.1611103 0.8139669 0.16111 NA NA
RIT1 gefitinib 0.1611659 0.8139669 0.16117 NA NA
CSF3R neratinib 0.1612767 0.8139669 0.16128 NA NA
FBXW7 imatinib 0.1616916 0.8139669 0.16169 NA NA
NOTCH2 regorafenib 0.1621855 0.8139669 0.16219 NA NA
KMT2A fluorouracil 0.1623496 0.8139669 0.16235 NA NA
ABL1 ruxolitinib 0.1623760 0.8139669 0.16238 NA NA
CTNNB1 fulvestrant 0.1624991 0.8139669 0.16250 NA NA
PDGFRA sunitinib 0.1625269 0.8139669 0.16253 NA NA
SRSF2 lapatinib 0.1626520 0.8139669 0.16265 NA NA
AKT1 vemurafenib 0.1629510 0.8139669 0.16295 NA NA
CYP19A1 nilotinib 0.1633178 0.8139669 0.16332 NA NA
CDK4 cabozantinib 0.1633468 0.8139669 0.16335 NA NA
RET lapatinib 0.1635140 0.8139669 0.16351 NA NA
EGF selumetinib 0.1635275 0.8139669 0.16353 NA NA
SMC3 azd 0.1637223 0.8139669 0.16372 NA NA
GATA3 vemurafenib 0.1643528 0.8159440 0.16435 NA NA
ROS1 ruxolitinib 0.1652562 0.8181245 0.16526 NA NA
TPMT gefitinib 0.1653865 0.8181245 0.16539 NA NA
VHL lapatinib 0.1657053 0.8181245 0.16571 NA NA
ERBB4 erlotinib 0.1663518 0.8181245 0.16635 NA NA
CTLA4 ibrutinib 0.1663882 0.8181245 0.16639 NA NA
CYP19A1 cyclophosphamide 0.1664216 0.8181245 0.16642 NA NA
HRAS neratinib 0.1666057 0.8181245 0.16661 NA NA
FANCL imatinib 0.1666593 0.8181245 0.16666 NA NA
DNAJB1 azd 0.1671200 0.8183088 0.16712 NA NA
MET cyclophosphamide 0.1671638 0.8183088 0.16716 NA NA
MGMT temozolomide 0.1678755 0.8199784 0.16788 NA NA
ERBB2 dasatinib 0.1679727 0.8199784 0.16797 NA NA
TSC1 neratinib 0.1690040 0.8215360 0.16900 NA NA
RET vandetanib 0.1691629 0.8215360 0.16916 NA NA
CREBBP gefitinib 0.1695092 0.8215360 0.16951 NA NA
MAP2K2 erlotinib 0.1698711 0.8215360 0.16987 NA NA
CXCR4 crizotinib 0.1699645 0.8215360 0.16996 NA NA
AKT2 gefitinib 0.1702013 0.8215360 0.17020 NA NA
RIT1 ibrutinib 0.1702498 0.8215360 0.17025 NA NA
DNAJB1 crizotinib 0.1706317 0.8215360 0.17063 NA NA
PTPN11 trametinib 0.1708413 0.8215360 0.17084 NA NA
PIGA ruxolitinib 0.1710802 0.8215360 0.17108 NA NA
CTCF afatinib 0.1713970 0.8215360 0.17140 NA NA
SSX1 cyclophosphamide 0.1714083 0.8215360 0.17141 NA NA
ROS1 afatinib 0.1715284 0.8215360 0.17153 NA NA
CSF3R nilotinib 0.1715733 0.8215360 0.17157 NA NA
RPL10 nilotinib 0.1720057 0.8217034 0.17201 NA NA
ALK fluorouracil 0.1722690 0.8217034 0.17227 NA NA
FLCN nilotinib 0.1723116 0.8217034 0.17231 NA NA
EED imatinib 0.1727877 0.8224847 0.17279 NA NA
JAK1 cyclophosphamide 0.1731296 0.8224847 0.17313 NA NA
PTPN11 lapatinib 0.1732828 0.8224847 0.17328 NA NA
IL7R fulvestrant 0.1739823 0.8224847 0.17398 NA NA
BTK temozolomide 0.1743973 0.8224847 0.17440 NA NA
STAT3 vandetanib 0.1745649 0.8224847 0.17456 NA NA
RAD21 gefitinib 0.1746775 0.8224847 0.17468 NA NA
FBXW7 afatinib 0.1748361 0.8224847 0.17484 NA NA
EGF pazopanib 0.1752988 0.8224847 0.17530 NA NA
MYCN dasatinib 0.1756074 0.8224847 0.17561 NA NA
AKT3 imatinib 0.1756744 0.8224847 0.17567 NA NA
EGF vandetanib 0.1756788 0.8224847 0.17568 NA NA
CXCR4 temozolomide 0.1757492 0.8224847 0.17575 NA NA
CDC73 gefitinib 0.1759263 0.8224847 0.17593 NA NA
IDH2 fulvestrant 0.1760724 0.8224847 0.17607 NA NA
BRCA2 selumetinib 0.1762300 0.8224847 0.17623 NA NA
CBLB temozolomide 0.1766069 0.8228117 0.17661 NA NA
GATA2 sunitinib 0.1769371 0.8228117 0.17694 NA NA
IDH2 imatinib 0.1770530 0.8228117 0.17705 NA NA
IDH1 regorafenib 0.1775547 0.8228117 0.17755 NA NA
VHL temozolomide 0.1776761 0.8228117 0.17768 NA NA
GNAS belinostat 0.1778414 0.8228117 0.17784 NA NA
GNA11 vemurafenib 0.1779433 0.8228117 0.17794 NA NA
CD274 olaparib 0.1782599 0.8231897 0.17826 NA NA
RIT1 crizotinib 0.1790213 0.8256178 0.17902 NA NA
TSC1 dabrafenib 0.1796741 0.8270773 0.17967 NA NA
ABL1 belinostat 0.1800207 0.8270773 0.18002 NA NA
SETBP1 gefitinib 0.1801410 0.8270773 0.18014 NA NA
CBLB vemurafenib 0.1802816 0.8270773 0.18028 NA NA
G6PD gefitinib 0.1809687 0.8276715 0.18097 NA NA
PDGFRB pazopanib 0.1809713 0.8276715 0.18097 NA NA
GNAQ vandetanib 0.1818330 0.8276715 0.18183 NA NA
ALK lapatinib 0.1820481 0.8276715 0.18205 NA NA
KIT pazopanib 0.1823374 0.8276715 0.18234 NA NA
ERBB4 cabozantinib 0.1825959 0.8276715 0.18260 NA NA
ATM vemurafenib 0.1826621 0.8276715 0.18266 NA NA
UGT1A1 cyclophosphamide 0.1827105 0.8276715 0.18271 NA NA
SMO regorafenib 0.1829769 0.8276715 0.18298 NA NA
JAK1 temozolomide 0.1831782 0.8276715 0.18318 NA NA
RAD21 cabozantinib 0.1832088 0.8276715 0.18321 NA NA
CD274 fluorouracil 0.1835994 0.8276715 0.18360 NA NA
ESR1 trametinib 0.1839575 0.8276715 0.18396 NA NA
CYP19A1 sunitinib 0.1840148 0.8276715 0.18401 NA NA
FANCL nilotinib 0.1843329 0.8276715 0.18433 NA NA
PIGA erlotinib 0.1843881 0.8276715 0.18439 NA NA
CTCF gefitinib 0.1844255 0.8276715 0.18443 NA NA
RET ruxolitinib 0.1851983 0.8300768 0.18520 NA NA
FLCN sunitinib 0.1855494 0.8302316 0.18555 NA NA
MET fulvestrant 0.1858576 0.8302316 0.18586 NA NA
VHL dabrafenib 0.1868603 0.8302316 0.18686 NA NA
U2AF1 selumetinib 0.1868736 0.8302316 0.18687 NA NA
CD274 crizotinib 0.1869796 0.8302316 0.18698 NA NA
PRPF40B neratinib 0.1873324 0.8302316 0.18733 NA NA
CSF3R imatinib 0.1873940 0.8302316 0.18739 NA NA
MAP2K1 ibrutinib 0.1879374 0.8302316 0.18794 NA NA
ASXL1 nilotinib 0.1880436 0.8302316 0.18804 NA NA
KMT2A dasatinib 0.1882251 0.8302316 0.18823 NA NA
ALK temozolomide 0.1882566 0.8302316 0.18826 NA NA
PTPN11 temozolomide 0.1884716 0.8302316 0.18847 NA NA
PAX8 erlotinib 0.1884806 0.8302316 0.18848 NA NA
CALR cyclophosphamide 0.1885490 0.8302316 0.18855 NA NA
CALR afatinib 0.1902247 0.8348867 0.19022 NA NA
IDH1 cyclophosphamide 0.1903190 0.8348867 0.19032 NA NA
PDGFRA trametinib 0.1903208 0.8348867 0.19032 NA NA
SRSF2 trametinib 0.1909143 0.8349555 0.19091 NA NA
MGMT vandetanib 0.1909706 0.8349555 0.19097 NA NA
JAK2 azd 0.1912155 0.8349555 0.19122 NA NA
MYCN nilotinib 0.1912894 0.8349555 0.19129 NA NA
CXCR4 dasatinib 0.1917449 0.8352892 0.19174 NA NA
BCORL1 erlotinib 0.1918424 0.8352892 0.19184 NA NA
RAD21 fluorouracil 0.1924574 0.8360782 0.19246 NA NA
PTPN11 ibrutinib 0.1925193 0.8360782 0.19252 NA NA
CXCR4 cabozantinib 0.1928962 0.8360782 0.19290 NA NA
DNAJB1 dabrafenib 0.1934385 0.8360782 0.19344 NA NA
JAK3 olaparib 0.1935261 0.8360782 0.19353 NA NA
STAT3 afatinib 0.1935875 0.8360782 0.19359 NA NA
ETV6 temozolomide 0.1938471 0.8360782 0.19385 NA NA
CD79B ruxolitinib 0.1939320 0.8360782 0.19393 NA NA
RUNX1 erlotinib 0.1942156 0.8361799 0.19422 NA NA
NT5C2 imatinib 0.1944327 0.8361799 0.19443 NA NA
ASXL1 gefitinib 0.1953168 0.8366549 0.19532 NA NA
HRAS fulvestrant 0.1953622 0.8366549 0.19536 NA NA
U2AF1 neratinib 0.1953924 0.8366549 0.19539 NA NA
EZH2 cabozantinib 0.1954980 0.8366549 0.19550 NA NA
FANCL pazopanib 0.1961635 0.8368360 0.19616 NA NA
PRPF8 temozolomide 0.1962058 0.8368360 0.19621 NA NA
ERBB2 afatinib 0.1962848 0.8368360 0.19628 NA NA
SETBP1 vandetanib 0.1965746 0.8368360 0.19657 NA NA
PHF6 crizotinib 0.1969099 0.8368360 0.19691 NA NA
FGFR1 gefitinib 0.1970554 0.8368360 0.19706 NA NA
DPYD vemurafenib 0.1972116 0.8368360 0.19721 NA NA
JAK3 cyclophosphamide 0.1976407 0.8376427 0.19764 NA NA
DNAJB1 cyclophosphamide 0.1981339 0.8387190 0.19813 NA NA
BRCA1 cabozantinib 0.1984399 0.8390008 0.19844 NA NA
GATA1 cabozantinib 0.1987349 0.8392360 0.19873 NA NA
NCOA2 pazopanib 0.1998764 0.8399864 0.19988 NA NA
RIT1 regorafenib 0.1999553 0.8399864 0.19996 NA NA
GNA11 neratinib 0.2002192 0.8399864 0.20022 NA NA
IDH2 afatinib 0.2002219 0.8399864 0.20022 NA NA
GATA1 sunitinib 0.2003370 0.8399864 0.20034 NA NA
PIGA belinostat 0.2003505 0.8399864 0.20035 NA NA
GNA11 nilotinib 0.2010245 0.8416504 0.20102 NA NA
CDK4 fulvestrant 0.2012277 0.8416504 0.20123 NA NA
IL7R azd 0.2028546 0.8429577 0.20285 NA NA
CSF3R azd 0.2028828 0.8429577 0.20288 NA NA
BRCA1 sunitinib 0.2029629 0.8429577 0.20296 NA NA
FBXW7 fluorouracil 0.2029792 0.8429577 0.20298 NA NA
STAG2 dabrafenib 0.2040979 0.8429577 0.20410 NA NA
PTCH1 cabozantinib 0.2043150 0.8429577 0.20432 NA NA
KRAS temozolomide 0.2044885 0.8429577 0.20449 NA NA
SETBP1 temozolomide 0.2047547 0.8429577 0.20475 NA NA
RET gefitinib 0.2049189 0.8429577 0.20492 NA NA
JAK1 selumetinib 0.2050591 0.8429577 0.20506 NA NA
PTEN ruxolitinib 0.2051818 0.8429577 0.20518 NA NA
CTNNB1 temozolomide 0.2056164 0.8429577 0.20562 NA NA
STAT3 regorafenib 0.2056564 0.8429577 0.20566 NA NA
JAK2 vandetanib 0.2056568 0.8429577 0.20566 NA NA
NT5C2 regorafenib 0.2063329 0.8429577 0.20633 NA NA
TPMT lapatinib 0.2063631 0.8429577 0.20636 NA NA
BTK fulvestrant 0.2063932 0.8429577 0.20639 NA NA
ERBB2 neratinib 0.2066706 0.8429577 0.20667 NA NA
SETBP1 dabrafenib 0.2068304 0.8429577 0.20683 NA NA
ERBB4 regorafenib 0.2068637 0.8429577 0.20686 NA NA
STAT3 ibrutinib 0.2071369 0.8429577 0.20714 NA NA
BCORL1 belinostat 0.2074537 0.8429577 0.20745 NA NA
GATA2 ibrutinib 0.2077625 0.8429577 0.20776 NA NA
JAK3 lapatinib 0.2077682 0.8429577 0.20777 NA NA
ABL1 temozolomide 0.2078183 0.8429577 0.20782 NA NA
NCOA2 fulvestrant 0.2080174 0.8429577 0.20802 NA NA
CTNNB1 gefitinib 0.2081323 0.8429577 0.20813 NA NA
G6PD vandetanib 0.2082743 0.8429577 0.20827 NA NA
EGF ibrutinib 0.2085764 0.8432069 0.20858 NA NA
DDIT3 dasatinib 0.2089324 0.8436728 0.20893 NA NA
PIGA fluorouracil 0.2097762 0.8460392 0.20978 NA NA
CDKN2A ibrutinib 0.2100012 0.8460392 0.21000 NA NA
PDGFB ruxolitinib 0.2112854 0.8502356 0.21129 NA NA
JAK2 regorafenib 0.2116803 0.8503640 0.21168 NA NA
MGMT afatinib 0.2118025 0.8503640 0.21180 NA NA
CBL crizotinib 0.2125045 0.8517609 0.21250 NA NA
CALR ibrutinib 0.2126741 0.8517609 0.21267 NA NA
MPL temozolomide 0.2133527 0.8517609 0.21335 NA NA
RUNX1 imatinib 0.2134733 0.8517609 0.21347 NA NA
DNAJB1 nilotinib 0.2139098 0.8517609 0.21391 NA NA
TSC1 ibrutinib 0.2141178 0.8517609 0.21412 NA NA
CALR pazopanib 0.2141930 0.8517609 0.21419 NA NA
CDK4 sunitinib 0.2143020 0.8517609 0.21430 NA NA
CDK6 dabrafenib 0.2147605 0.8517609 0.21476 NA NA
XPO1 dasatinib 0.2148036 0.8517609 0.21480 NA NA
HRAS vemurafenib 0.2155713 0.8517609 0.21557 NA NA
RET erlotinib 0.2156089 0.8517609 0.21561 NA NA
NCOA2 trametinib 0.2156555 0.8517609 0.21566 NA NA
CTNNB1 erlotinib 0.2157214 0.8517609 0.21572 NA NA
CDK4 lapatinib 0.2157956 0.8517609 0.21580 NA NA
CD79B sunitinib 0.2161821 0.8520326 0.21618 NA NA
EGF nilotinib 0.2165890 0.8520326 0.21659 NA NA
SMC3 olaparib 0.2165937 0.8520326 0.21659 NA NA
MET trametinib 0.2171377 0.8532149 0.21714 NA NA
JAK1 vandetanib 0.2175356 0.8538211 0.21754 NA NA
CD79B regorafenib 0.2181528 0.8552857 0.21815 NA NA
TPMT olaparib 0.2193329 0.8585846 0.21933 NA NA
MET vandetanib 0.2195544 0.8585846 0.21955 NA NA
EGFR azd 0.2197291 0.8585846 0.21973 NA NA
UGT1A1 crizotinib 0.2205241 0.8602377 0.22052 NA NA
RPL10 cabozantinib 0.2206430 0.8602377 0.22064 NA NA
PDGFRA cabozantinib 0.2210144 0.8607283 0.22101 NA NA
AKT1 erlotinib 0.2216745 0.8611467 0.22167 NA NA
CDK6 trametinib 0.2219071 0.8611467 0.22191 NA NA
RUNX1 selumetinib 0.2219756 0.8611467 0.22198 NA NA
GATA3 lapatinib 0.2221046 0.8611467 0.22210 NA NA
XPO1 dabrafenib 0.2225415 0.8612441 0.22254 NA NA
RIT1 afatinib 0.2226212 0.8612441 0.22262 NA NA
CD79B temozolomide 0.2230203 0.8617012 0.22302 NA NA
ROS1 lapatinib 0.2232310 0.8617012 0.22323 NA NA
CSF3R dabrafenib 0.2243915 0.8646842 0.22439 NA NA
EGF cabozantinib 0.2251682 0.8646842 0.22517 NA NA
CD79B vemurafenib 0.2251826 0.8646842 0.22518 NA NA
AKT1 vandetanib 0.2252466 0.8646842 0.22525 NA NA
PDCD1 lapatinib 0.2254655 0.8646842 0.22547 NA NA
NOTCH1 nilotinib 0.2258924 0.8646842 0.22589 NA NA
DPYD erlotinib 0.2260758 0.8646842 0.22608 NA NA
MDM2 gefitinib 0.2261892 0.8646842 0.22619 NA NA
FANCL trametinib 0.2264859 0.8646842 0.22649 NA NA
TET2 fulvestrant 0.2267718 0.8646842 0.22677 NA NA
IDH2 erlotinib 0.2268140 0.8646842 0.22681 NA NA
MAP2K1 cabozantinib 0.2271271 0.8646842 0.22713 NA NA
KIT neratinib 0.2272109 0.8646842 0.22721 NA NA
NRAS sunitinib 0.2276144 0.8652805 0.22761 NA NA
PIGA trametinib 0.2279091 0.8654619 0.22791 NA NA
GNAS ibrutinib 0.2283673 0.8656530 0.22837 NA NA
AKT2 erlotinib 0.2285363 0.8656530 0.22854 NA NA
EGF temozolomide 0.2290065 0.8656530 0.22901 NA NA
CDKN2A selumetinib 0.2293566 0.8656530 0.22936 NA NA
TSC1 azd 0.2297525 0.8656530 0.22975 NA NA
SF3B1 vandetanib 0.2298798 0.8656530 0.22988 NA NA
CDK4 selumetinib 0.2302961 0.8656530 0.23030 NA NA
EZH2 azd 0.2304676 0.8656530 0.23047 NA NA
NRAS ruxolitinib 0.2305854 0.8656530 0.23059 NA NA
TET2 pazopanib 0.2306595 0.8656530 0.23066 NA NA
CD274 regorafenib 0.2309083 0.8656530 0.23091 NA NA
NPM1 fulvestrant 0.2309231 0.8656530 0.23092 NA NA
EZH2 olaparib 0.2316089 0.8659530 0.23161 NA NA
MGMT dasatinib 0.2320758 0.8659530 0.23208 NA NA
NRAS cabozantinib 0.2323251 0.8659530 0.23233 NA NA
FLT3 ibrutinib 0.2324658 0.8659530 0.23247 NA NA
DDIT3 erlotinib 0.2324701 0.8659530 0.23247 NA NA
ATM neratinib 0.2324855 0.8659530 0.23249 NA NA
IDH1 dabrafenib 0.2330706 0.8664682 0.23307 NA NA
AKT3 regorafenib 0.2333180 0.8664682 0.23332 NA NA
PTPN11 neratinib 0.2334787 0.8664682 0.23348 NA NA
PAX8 pazopanib 0.2336994 0.8664682 0.23370 NA NA
NT5C2 gefitinib 0.2340763 0.8664682 0.23408 NA NA
PHF6 vemurafenib 0.2342709 0.8664682 0.23427 NA NA
ROS1 fulvestrant 0.2343543 0.8664682 0.23435 NA NA
DNAJB1 imatinib 0.2355069 0.8667267 0.23551 NA NA
BCORL1 vandetanib 0.2356221 0.8667267 0.23562 NA NA
TPMT vandetanib 0.2358167 0.8667267 0.23582 NA NA
CDK4 afatinib 0.2359976 0.8667267 0.23600 NA NA
FLCN ibrutinib 0.2366080 0.8667267 0.23661 NA NA
SETBP1 selumetinib 0.2369905 0.8667267 0.23699 NA NA
GNA11 azd 0.2372309 0.8667267 0.23723 NA NA
BTK belinostat 0.2375233 0.8667267 0.23752 NA NA
MPL erlotinib 0.2375887 0.8667267 0.23759 NA NA
EED vandetanib 0.2376284 0.8667267 0.23763 NA NA
CDC73 fulvestrant 0.2377735 0.8667267 0.23777 NA NA
PHF6 fluorouracil 0.2378370 0.8667267 0.23784 NA NA
CSF3R pazopanib 0.2379733 0.8667267 0.23797 NA NA
DPYD gefitinib 0.2382705 0.8667267 0.23827 NA NA
FBXW7 vemurafenib 0.2383796 0.8667267 0.23838 NA NA
RET crizotinib 0.2389903 0.8667267 0.23899 NA NA
CRLF2 imatinib 0.2390427 0.8667267 0.23904 NA NA
CBLB regorafenib 0.2395929 0.8667267 0.23959 NA NA
MGMT lapatinib 0.2397677 0.8667267 0.23977 NA NA
CTLA4 fluorouracil 0.2402767 0.8667267 0.24028 NA NA
JAK3 dasatinib 0.2402918 0.8667267 0.24029 NA NA
ROS1 trametinib 0.2403793 0.8667267 0.24038 NA NA
IKZF1 cyclophosphamide 0.2404186 0.8667267 0.24042 NA NA
MYD88 dabrafenib 0.2408578 0.8667267 0.24086 NA NA
ZRSR2 regorafenib 0.2413351 0.8667267 0.24134 NA NA
SMC1A vandetanib 0.2415598 0.8667267 0.24156 NA NA
MDM2 ruxolitinib 0.2416067 0.8667267 0.24161 NA NA
CRLF2 azd 0.2416519 0.8667267 0.24165 NA NA
AKT3 ibrutinib 0.2417159 0.8667267 0.24172 NA NA
HRAS afatinib 0.2422902 0.8667267 0.24229 NA NA
TET2 lapatinib 0.2425768 0.8667267 0.24258 NA NA
IDH1 afatinib 0.2427725 0.8667267 0.24277 NA NA
ATM regorafenib 0.2428204 0.8667267 0.24282 NA NA
FGFR2 belinostat 0.2428319 0.8667267 0.24283 NA NA
AKT1 lapatinib 0.2447114 0.8674143 0.24471 NA NA
GATA2 nilotinib 0.2450251 0.8674143 0.24503 NA NA
CRLF2 selumetinib 0.2452080 0.8674143 0.24521 NA NA
CDK6 sunitinib 0.2452747 0.8674143 0.24527 NA NA
SMO imatinib 0.2453198 0.8674143 0.24532 NA NA
CSF3R vemurafenib 0.2456264 0.8674143 0.24563 NA NA
BTK imatinib 0.2456728 0.8674143 0.24567 NA NA
CREBBP fulvestrant 0.2457193 0.8674143 0.24572 NA NA
GATA1 lapatinib 0.2459512 0.8674143 0.24595 NA NA
PML nilotinib 0.2462058 0.8674143 0.24621 NA NA
KIT crizotinib 0.2466017 0.8674143 0.24660 NA NA
PDGFB pazopanib 0.2466642 0.8674143 0.24666 NA NA
RET neratinib 0.2474878 0.8674143 0.24749 NA NA
PDGFB azd 0.2475165 0.8674143 0.24752 NA NA
GNB1 cabozantinib 0.2476203 0.8674143 0.24762 NA NA
MGMT vemurafenib 0.2488404 0.8674143 0.24884 NA NA
CRLF2 vandetanib 0.2489356 0.8674143 0.24894 NA NA
GNB1 belinostat 0.2491958 0.8674143 0.24920 NA NA
MGMT gefitinib 0.2498351 0.8674143 0.24984 NA NA
CALR olaparib 0.2507276 0.8674143 0.25073 NA NA
MET olaparib 0.2511607 0.8674143 0.25116 NA NA
MDM2 olaparib 0.2517161 0.8674143 0.25172 NA NA
G6PD sunitinib 0.2518013 0.8674143 0.25180 NA NA
EGFR afatinib 0.2518397 0.8674143 0.25184 NA NA
TPMT trametinib 0.2520717 0.8674143 0.25207 NA NA
SETBP1 dasatinib 0.2521967 0.8674143 0.25220 NA NA
STAG2 selumetinib 0.2523100 0.8674143 0.25231 NA NA
EGF vemurafenib 0.2527242 0.8674143 0.25272 NA NA
CXCR4 vandetanib 0.2528544 0.8674143 0.25285 NA NA
JAK2 cyclophosphamide 0.2532387 0.8674143 0.25324 NA NA
SH2B3 belinostat 0.2533078 0.8674143 0.25331 NA NA
PTEN olaparib 0.2533258 0.8674143 0.25333 NA NA
CTNNB1 dasatinib 0.2535051 0.8674143 0.25351 NA NA
AKT2 fluorouracil 0.2539708 0.8674143 0.25397 NA NA
GNAQ neratinib 0.2542162 0.8674143 0.25422 NA NA
HRAS trametinib 0.2542381 0.8674143 0.25424 NA NA
DNAJB1 fulvestrant 0.2543262 0.8674143 0.25433 NA NA
ATM vandetanib 0.2544104 0.8674143 0.25441 NA NA
GNA11 crizotinib 0.2550325 0.8674143 0.25503 NA NA
TSC2 cyclophosphamide 0.2553250 0.8674143 0.25533 NA NA
TP53 vemurafenib 0.2553975 0.8674143 0.25540 NA NA
SETBP1 erlotinib 0.2557903 0.8674143 0.25579 NA NA
RAD21 selumetinib 0.2558348 0.8674143 0.25583 NA NA
RAD21 ruxolitinib 0.2560520 0.8674143 0.25605 NA NA
CBLB lapatinib 0.2563815 0.8674143 0.25638 NA NA
SMO dabrafenib 0.2563832 0.8674143 0.25638 NA NA
ASXL1 neratinib 0.2564350 0.8674143 0.25644 NA NA
CDK6 temozolomide 0.2564922 0.8674143 0.25649 NA NA
GATA3 cyclophosphamide 0.2567670 0.8674143 0.25677 NA NA
RAD21 temozolomide 0.2568042 0.8674143 0.25680 NA NA
MPL fluorouracil 0.2570595 0.8674143 0.25706 NA NA
UGT1A1 regorafenib 0.2573217 0.8674143 0.25732 NA NA
AKT2 selumetinib 0.2575985 0.8674143 0.25760 NA NA
CRLF2 ruxolitinib 0.2576407 0.8674143 0.25764 NA NA
MGMT ruxolitinib 0.2579077 0.8674143 0.25791 NA NA
NPM1 ibrutinib 0.2580132 0.8674143 0.25801 NA NA
CDK6 regorafenib 0.2580522 0.8674143 0.25805 NA NA
CD274 vandetanib 0.2581045 0.8674143 0.25810 NA NA
CALR azd 0.2581482 0.8674143 0.25815 NA NA
VHL selumetinib 0.2582785 0.8674143 0.25828 NA NA
PDGFRB ibrutinib 0.2584041 0.8674143 0.25840 NA NA
SETD2 fulvestrant 0.2588051 0.8674143 0.25881 NA NA
TPMT pazopanib 0.2589317 0.8674143 0.25893 NA NA
CD79B belinostat 0.2591552 0.8674143 0.25916 NA NA
TET2 sunitinib 0.2597084 0.8674143 0.25971 NA NA
FANCL belinostat 0.2597690 0.8674143 0.25977 NA NA
PAX5 afatinib 0.2600146 0.8674143 0.26001 NA NA
PRPF8 erlotinib 0.2604212 0.8674143 0.26042 NA NA
PTEN azd 0.2607677 0.8674143 0.26077 NA NA
GATA2 selumetinib 0.2608859 0.8674143 0.26089 NA NA
GNB1 dasatinib 0.2610861 0.8674143 0.26109 NA NA
JAK1 sunitinib 0.2612506 0.8674143 0.26125 NA NA
KMT2A crizotinib 0.2612591 0.8674143 0.26126 NA NA
SMC3 dabrafenib 0.2613379 0.8674143 0.26134 NA NA
AKT1 olaparib 0.2619009 0.8675957 0.26190 NA NA
PAX5 fluorouracil 0.2620065 0.8675957 0.26201 NA NA
WHSC1 dabrafenib 0.2624760 0.8675957 0.26248 NA NA
MAP2K2 imatinib 0.2628054 0.8675957 0.26281 NA NA
CSF3R crizotinib 0.2629812 0.8675957 0.26298 NA NA
IDH2 lapatinib 0.2631941 0.8675957 0.26319 NA NA
PML olaparib 0.2632816 0.8675957 0.26328 NA NA
SF1 crizotinib 0.2639172 0.8675957 0.26392 NA NA
MAP2K1 azd 0.2639379 0.8675957 0.26394 NA NA
ETV6 fluorouracil 0.2643094 0.8675957 0.26431 NA NA
MET pazopanib 0.2643242 0.8675957 0.26432 NA NA
ZRSR2 nilotinib 0.2643630 0.8675957 0.26436 NA NA
CREBBP ruxolitinib 0.2647155 0.8679226 0.26472 NA NA
MYCN cyclophosphamide 0.2649578 0.8679226 0.26496 NA NA
SMC1A afatinib 0.2653342 0.8683439 0.26533 NA NA
AKT3 olaparib 0.2660523 0.8688368 0.26605 NA NA
SMC1A erlotinib 0.2661647 0.8688368 0.26616 NA NA
GNAQ crizotinib 0.2662285 0.8688368 0.26623 NA NA
TSC2 azd 0.2666255 0.8693230 0.26663 NA NA
MPL dasatinib 0.2681902 0.8736121 0.26819 NA NA
TSC1 dasatinib 0.2684477 0.8736390 0.26845 NA NA
DDIT3 lapatinib 0.2688137 0.8740185 0.26881 NA NA
NOTCH2 lapatinib 0.2694024 0.8751207 0.26940 NA NA
SSX1 cabozantinib 0.2698860 0.8758802 0.26989 NA NA
MYD88 cabozantinib 0.2705198 0.8762072 0.27052 NA NA
IDH1 neratinib 0.2706290 0.8762072 0.27063 NA NA
EZH2 nilotinib 0.2708587 0.8762072 0.27086 NA NA
AKT1 gefitinib 0.2710276 0.8762072 0.27103 NA NA
CDC73 sunitinib 0.2712626 0.8762072 0.27126 NA NA
WT1 lapatinib 0.2714867 0.8762072 0.27149 NA NA
CDK6 azd 0.2719821 0.8769984 0.27198 NA NA
MYD88 lapatinib 0.2727428 0.8782850 0.27274 NA NA
JAK2 fulvestrant 0.2731170 0.8782850 0.27312 NA NA
DNAJB1 fluorouracil 0.2734351 0.8782850 0.27344 NA NA
MYCN erlotinib 0.2736975 0.8782850 0.27370 NA NA
CYP19A1 lapatinib 0.2738891 0.8782850 0.27389 NA NA
ERBB2 gefitinib 0.2741193 0.8782850 0.27412 NA NA
NOTCH1 vemurafenib 0.2741352 0.8782850 0.27414 NA NA
NRAS vemurafenib 0.2747336 0.8792858 0.27473 NA NA
PDGFRA selumetinib 0.2749493 0.8792858 0.27495 NA NA
FANCL fulvestrant 0.2754040 0.8795956 0.27540 NA NA
RAD21 pazopanib 0.2756366 0.8795956 0.27564 NA NA
KMT2A imatinib 0.2757990 0.8795956 0.27580 NA NA
FGFR1 regorafenib 0.2760560 0.8796148 0.27606 NA NA
GNAQ erlotinib 0.2763653 0.8797903 0.27637 NA NA
KRAS fulvestrant 0.2766131 0.8797903 0.27661 NA NA
TSC1 imatinib 0.2772743 0.8803274 0.27727 NA NA
FGFR2 fluorouracil 0.2774309 0.8803274 0.27743 NA NA
MGMT trametinib 0.2783193 0.8803274 0.27832 NA NA
NRAS neratinib 0.2783736 0.8803274 0.27837 NA NA
ALK imatinib 0.2787671 0.8803274 0.27877 NA NA
MGMT fulvestrant 0.2788073 0.8803274 0.27881 NA NA
AKT1 ibrutinib 0.2790808 0.8803274 0.27908 NA NA
ROS1 sunitinib 0.2791187 0.8803274 0.27912 NA NA
CBL nilotinib 0.2792044 0.8803274 0.27920 NA NA
FLT3 dabrafenib 0.2794287 0.8803274 0.27943 NA NA
NOTCH2 gefitinib 0.2795448 0.8803274 0.27954 NA NA
ABL1 fulvestrant 0.2803031 0.8809381 0.28030 NA NA
CEBPA temozolomide 0.2806538 0.8809381 0.28065 NA NA
SETBP1 olaparib 0.2806725 0.8809381 0.28067 NA NA
SF1 sunitinib 0.2809586 0.8809381 0.28096 NA NA
STAT3 cabozantinib 0.2811915 0.8809381 0.28119 NA NA
U2AF1 dabrafenib 0.2819991 0.8809381 0.28200 NA NA
TSC2 sunitinib 0.2822305 0.8809381 0.28223 NA NA
AKT3 erlotinib 0.2822462 0.8809381 0.28225 NA NA
CXCR4 ibrutinib 0.2825615 0.8809381 0.28256 NA NA
ERBB2 trametinib 0.2825628 0.8809381 0.28256 NA NA
ATM ibrutinib 0.2827345 0.8809381 0.28273 NA NA
AKT2 crizotinib 0.2831390 0.8809381 0.28314 NA NA
CYP19A1 fulvestrant 0.2831609 0.8809381 0.28316 NA NA
MDM2 cyclophosphamide 0.2833971 0.8809381 0.28340 NA NA
MPL azd 0.2837117 0.8809381 0.28371 NA NA
BRCA1 lapatinib 0.2837601 0.8809381 0.28376 NA NA
CREBBP belinostat 0.2843252 0.8816267 0.28433 NA NA
AKT3 temozolomide 0.2849774 0.8816267 0.28498 NA NA
EGFR vandetanib 0.2853916 0.8816267 0.28539 NA NA
PTCH1 dasatinib 0.2856356 0.8816267 0.28564 NA NA
FLCN erlotinib 0.2860245 0.8816267 0.28602 NA NA
TP53 dasatinib 0.2863574 0.8816267 0.28636 NA NA
SMC1A trametinib 0.2863916 0.8816267 0.28639 NA NA
CTLA4 cyclophosphamide 0.2868338 0.8816267 0.28683 NA NA
CTCF trametinib 0.2869070 0.8816267 0.28691 NA NA
ERBB3 sunitinib 0.2869264 0.8816267 0.28693 NA NA
CBLB nilotinib 0.2871786 0.8816267 0.28718 NA NA
PTPN11 ruxolitinib 0.2873910 0.8816267 0.28739 NA NA
CRLF2 vemurafenib 0.2877686 0.8816267 0.28777 NA NA
ESR1 olaparib 0.2881802 0.8816267 0.28818 NA NA
CTCF vandetanib 0.2881981 0.8816267 0.28820 NA NA
PIGA gefitinib 0.2884608 0.8816267 0.28846 NA NA
NOTCH1 selumetinib 0.2885067 0.8816267 0.28851 NA NA
KMT2A gefitinib 0.2885492 0.8816267 0.28855 NA NA
U2AF1 belinostat 0.2889914 0.8816267 0.28899 NA NA
TPMT fluorouracil 0.2892300 0.8816267 0.28923 NA NA
CXCR4 dabrafenib 0.2893574 0.8816267 0.28936 NA NA
MET regorafenib 0.2896133 0.8816267 0.28961 NA NA
GATA3 afatinib 0.2898703 0.8816267 0.28987 NA NA
EML4 selumetinib 0.2900187 0.8816267 0.29002 NA NA
PDGFRB neratinib 0.2911880 0.8821411 0.29119 NA NA
ETV6 cabozantinib 0.2912697 0.8821411 0.29127 NA NA
CBLB erlotinib 0.2916741 0.8821411 0.29167 NA NA
PTPN11 vemurafenib 0.2920187 0.8821411 0.29202 NA NA
CTLA4 imatinib 0.2920684 0.8821411 0.29207 NA NA
CTCF regorafenib 0.2923352 0.8821411 0.29234 NA NA
TET2 azd 0.2924355 0.8821411 0.29244 NA NA
FBXW7 azd 0.2927105 0.8821411 0.29271 NA NA
MDM2 regorafenib 0.2932049 0.8821411 0.29320 NA NA
GATA3 ruxolitinib 0.2934338 0.8821411 0.29343 NA NA
IKZF1 temozolomide 0.2934346 0.8821411 0.29343 NA NA
FGFR2 cyclophosphamide 0.2935343 0.8821411 0.29353 NA NA
IDH2 vandetanib 0.2935755 0.8821411 0.29358 NA NA
ASXL1 fluorouracil 0.2939734 0.8821411 0.29397 NA NA
IL7R afatinib 0.2939743 0.8821411 0.29397 NA NA
GATA2 vemurafenib 0.2950040 0.8821411 0.29500 NA NA
SF1 neratinib 0.2954882 0.8821411 0.29549 NA NA
SMC1A fluorouracil 0.2955037 0.8821411 0.29550 NA NA
ERBB4 fluorouracil 0.2955055 0.8821411 0.29551 NA NA
PRPF40B gefitinib 0.2961110 0.8821411 0.29611 NA NA
ERBB2 imatinib 0.2961755 0.8821411 0.29618 NA NA
DDIT3 temozolomide 0.2963246 0.8821411 0.29632 NA NA
SMO cyclophosphamide 0.2963860 0.8821411 0.29639 NA NA
AKT2 dasatinib 0.2963964 0.8821411 0.29640 NA NA
CD79B trametinib 0.2968588 0.8821411 0.29686 NA NA
FANCL temozolomide 0.2969751 0.8821411 0.29698 NA NA
TET2 erlotinib 0.2973793 0.8821411 0.29738 NA NA
NPM1 azd 0.2976666 0.8821411 0.29767 NA NA
DPYD belinostat 0.2978744 0.8821411 0.29787 NA NA
RUNX1 azd 0.2978920 0.8821411 0.29789 NA NA
UGT1A1 ruxolitinib 0.2979995 0.8821411 0.29800 NA NA
PRPF40B ibrutinib 0.2982417 0.8821411 0.29824 NA NA
AKT2 olaparib 0.2991931 0.8828175 0.29919 NA NA
TSC2 dasatinib 0.2997123 0.8828175 0.29971 NA NA
MGMT nilotinib 0.3000538 0.8828175 0.30005 NA NA
CSF3R lapatinib 0.3001644 0.8828175 0.30016 NA NA
EED pazopanib 0.3002423 0.8828175 0.30024 NA NA
FGFR3 regorafenib 0.3005907 0.8828175 0.30059 NA NA
PRPF40B ruxolitinib 0.3008615 0.8828175 0.30086 NA NA
NT5C2 dabrafenib 0.3009126 0.8828175 0.30091 NA NA
NPM1 cabozantinib 0.3013980 0.8828175 0.30140 NA NA
MPL afatinib 0.3014431 0.8828175 0.30144 NA NA
CEBPA azd 0.3014960 0.8828175 0.30150 NA NA
ABL1 crizotinib 0.3022158 0.8828175 0.30222 NA NA
PTCH1 azd 0.3023110 0.8828175 0.30231 NA NA
ZRSR2 lapatinib 0.3028480 0.8828175 0.30285 NA NA
PRPF40B fluorouracil 0.3029401 0.8828175 0.30294 NA NA
ABL1 cabozantinib 0.3029475 0.8828175 0.30295 NA NA
RIT1 temozolomide 0.3038985 0.8828175 0.30390 NA NA
SETBP1 afatinib 0.3042461 0.8828175 0.30425 NA NA
CYP19A1 olaparib 0.3043830 0.8828175 0.30438 NA NA
ESR1 gefitinib 0.3045810 0.8828175 0.30458 NA NA
CTLA4 fulvestrant 0.3049799 0.8828175 0.30498 NA NA
U2AF1 pazopanib 0.3050361 0.8828175 0.30504 NA NA
PDGFB neratinib 0.3051659 0.8828175 0.30517 NA NA
GATA3 erlotinib 0.3053780 0.8828175 0.30538 NA NA
NCOA2 nilotinib 0.3062132 0.8828175 0.30621 NA NA
ATM belinostat 0.3062787 0.8828175 0.30628 NA NA
ALK vemurafenib 0.3064787 0.8828175 0.30648 NA NA
AKT3 gefitinib 0.3065438 0.8828175 0.30654 NA NA
MPL cyclophosphamide 0.3067703 0.8828175 0.30677 NA NA
EED gefitinib 0.3071090 0.8828175 0.30711 NA NA
PDGFRA vandetanib 0.3074459 0.8828175 0.30745 NA NA
FGFR1 fluorouracil 0.3077045 0.8828175 0.30770 NA NA
AKT1 afatinib 0.3079994 0.8828175 0.30800 NA NA
CRLF2 lapatinib 0.3083616 0.8828175 0.30836 NA NA
BRAF belinostat 0.3085030 0.8828175 0.30850 NA NA
BCORL1 azd 0.3088967 0.8828175 0.30890 NA NA
ETV6 cyclophosphamide 0.3091910 0.8828175 0.30919 NA NA
TSC1 selumetinib 0.3094377 0.8828175 0.30944 NA NA
JAK1 ibrutinib 0.3097846 0.8828175 0.30978 NA NA
RAD21 cyclophosphamide 0.3098551 0.8828175 0.30986 NA NA
DNMT3A imatinib 0.3100619 0.8828175 0.31006 NA NA
IDH1 trametinib 0.3101846 0.8828175 0.31018 NA NA
BCORL1 sunitinib 0.3102331 0.8828175 0.31023 NA NA
TPMT erlotinib 0.3109754 0.8828175 0.31098 NA NA
ERBB4 sunitinib 0.3111662 0.8828175 0.31117 NA NA
AR pazopanib 0.3113639 0.8828175 0.31136 NA NA
GNAS selumetinib 0.3113969 0.8828175 0.31140 NA NA
PML trametinib 0.3122459 0.8828175 0.31225 NA NA
CREBBP neratinib 0.3125282 0.8828175 0.31253 NA NA
IDH1 fluorouracil 0.3134090 0.8828175 0.31341 NA NA
ATM dabrafenib 0.3134509 0.8828175 0.31345 NA NA
FGFR1 neratinib 0.3142733 0.8828175 0.31427 NA NA
NT5C2 cabozantinib 0.3143224 0.8828175 0.31432 NA NA
NRAS temozolomide 0.3147868 0.8828175 0.31479 NA NA
ALK trametinib 0.3149108 0.8828175 0.31491 NA NA
AKT2 azd 0.3150406 0.8828175 0.31504 NA NA
RET dasatinib 0.3153187 0.8828175 0.31532 NA NA
BCORL1 ibrutinib 0.3155659 0.8828175 0.31557 NA NA
AKT3 afatinib 0.3156911 0.8828175 0.31569 NA NA
HRAS cyclophosphamide 0.3160466 0.8828175 0.31605 NA NA
UGT1A1 imatinib 0.3163786 0.8828175 0.31638 NA NA
CDKN2A fluorouracil 0.3166316 0.8828175 0.31663 NA NA
BTK dasatinib 0.3168831 0.8828175 0.31688 NA NA
MYD88 gefitinib 0.3170349 0.8828175 0.31703 NA NA
EGFR olaparib 0.3170528 0.8828175 0.31705 NA NA
SMC1A ibrutinib 0.3176370 0.8828175 0.31764 NA NA
MYD88 ibrutinib 0.3177454 0.8828175 0.31775 NA NA
AKT3 lapatinib 0.3177864 0.8828175 0.31779 NA NA
CTLA4 ruxolitinib 0.3178868 0.8828175 0.31789 NA NA
CBL sunitinib 0.3182987 0.8828175 0.31830 NA NA
AKT3 selumetinib 0.3182989 0.8828175 0.31830 NA NA
CREBBP regorafenib 0.3183678 0.8828175 0.31837 NA NA
PRPF40B regorafenib 0.3184834 0.8828175 0.31848 NA NA
VHL vemurafenib 0.3188942 0.8828175 0.31889 NA NA
FLT3 pazopanib 0.3190784 0.8828175 0.31908 NA NA
GATA3 dasatinib 0.3193230 0.8828175 0.31932 NA NA
FGFR2 lapatinib 0.3194959 0.8828175 0.31950 NA NA
GNA11 cyclophosphamide 0.3198950 0.8828175 0.31989 NA NA
ROS1 temozolomide 0.3206533 0.8828175 0.32065 NA NA
NT5C2 azd 0.3207060 0.8828175 0.32071 NA NA
EGF ruxolitinib 0.3211726 0.8828175 0.32117 NA NA
PTPN11 fluorouracil 0.3212658 0.8828175 0.32127 NA NA
SF3B1 olaparib 0.3213662 0.8828175 0.32137 NA NA
CALR vandetanib 0.3215620 0.8828175 0.32156 NA NA
SF3B1 azd 0.3217139 0.8828175 0.32171 NA NA
CTCF azd 0.3221524 0.8828175 0.32215 NA NA
JAK1 nilotinib 0.3226560 0.8828175 0.32266 NA NA
PRPF40B dabrafenib 0.3227384 0.8828175 0.32274 NA NA
TSC2 nilotinib 0.3227612 0.8828175 0.32276 NA NA
CREBBP crizotinib 0.3231958 0.8828175 0.32320 NA NA
CXCR4 afatinib 0.3233187 0.8828175 0.32332 NA NA
BRCA1 temozolomide 0.3234468 0.8828175 0.32345 NA NA
CTLA4 azd 0.3234500 0.8828175 0.32345 NA NA
RIT1 pazopanib 0.3234541 0.8828175 0.32345 NA NA
IL7R regorafenib 0.3236656 0.8828175 0.32367 NA NA
GNB1 selumetinib 0.3236710 0.8828175 0.32367 NA NA
ASXL1 vemurafenib 0.3239676 0.8828175 0.32397 NA NA
PAX5 azd 0.3240109 0.8828175 0.32401 NA NA
PDGFRA regorafenib 0.3247031 0.8828175 0.32470 NA NA
SETBP1 vemurafenib 0.3247472 0.8828175 0.32475 NA NA
G6PD cabozantinib 0.3251186 0.8828175 0.32512 NA NA
ALK olaparib 0.3253829 0.8828175 0.32538 NA NA
CD79B fluorouracil 0.3253899 0.8828175 0.32539 NA NA
PHF6 pazopanib 0.3255305 0.8828175 0.32553 NA NA
IDH2 dabrafenib 0.3256308 0.8828175 0.32563 NA NA
RIT1 dabrafenib 0.3256308 0.8828175 0.32563 NA NA
WHSC1 erlotinib 0.3258074 0.8828175 0.32581 NA NA
CSF3R vandetanib 0.3260300 0.8828175 0.32603 NA NA
BCOR imatinib 0.3260497 0.8828175 0.32605 NA NA
PHF6 imatinib 0.3261765 0.8828175 0.32618 NA NA
KMT2A sunitinib 0.3266300 0.8833627 0.32663 NA NA
PDGFRB ruxolitinib 0.3271325 0.8837318 0.32713 NA NA
GNB1 dabrafenib 0.3273825 0.8837318 0.32738 NA NA
EED ibrutinib 0.3284269 0.8837318 0.32843 NA NA
PDGFB imatinib 0.3290742 0.8837318 0.32907 NA NA
AKT3 fluorouracil 0.3291512 0.8837318 0.32915 NA NA
BRCA1 regorafenib 0.3293828 0.8837318 0.32938 NA NA
ABL1 fluorouracil 0.3296373 0.8837318 0.32964 NA NA
UGT1A1 ibrutinib 0.3298241 0.8837318 0.32982 NA NA
ERBB3 imatinib 0.3301067 0.8837318 0.33011 NA NA
CSF3R olaparib 0.3303395 0.8837318 0.33034 NA NA
SF1 dasatinib 0.3304244 0.8837318 0.33042 NA NA
ESR1 lapatinib 0.3306838 0.8837318 0.33068 NA NA
TPMT azd 0.3307900 0.8837318 0.33079 NA NA
BCORL1 nilotinib 0.3309074 0.8837318 0.33091 NA NA
CALR vemurafenib 0.3310767 0.8837318 0.33108 NA NA
PIGA dasatinib 0.3312493 0.8837318 0.33125 NA NA
MET lapatinib 0.3313687 0.8837318 0.33137 NA NA
MAP2K1 vemurafenib 0.3317071 0.8837318 0.33171 NA NA
KIT gefitinib 0.3317245 0.8837318 0.33172 NA NA
PDCD1 nilotinib 0.3318322 0.8837318 0.33183 NA NA
MYD88 afatinib 0.3320613 0.8837318 0.33206 NA NA
MYCN afatinib 0.3331030 0.8847030 0.33310 NA NA
PDGFRA fluorouracil 0.3334048 0.8847030 0.33340 NA NA
AKT3 belinostat 0.3334805 0.8847030 0.33348 NA NA
CXCR4 ruxolitinib 0.3336917 0.8847030 0.33369 NA NA
IDH2 neratinib 0.3337619 0.8847030 0.33376 NA NA
NCOA2 regorafenib 0.3339495 0.8847030 0.33395 NA NA
SMC1A imatinib 0.3343171 0.8847030 0.33432 NA NA
PIK3CA gefitinib 0.3344455 0.8847030 0.33445 NA NA
JAK3 erlotinib 0.3348706 0.8851311 0.33487 NA NA
IKZF1 lapatinib 0.3351124 0.8851311 0.33511 NA NA
CEBPA neratinib 0.3356933 0.8859977 0.33569 NA NA
FLCN afatinib 0.3363242 0.8866217 0.33632 NA NA
GATA1 fulvestrant 0.3364356 0.8866217 0.33644 NA NA
SF1 imatinib 0.3371007 0.8868192 0.33710 NA NA
GNAQ fulvestrant 0.3372669 0.8868192 0.33727 NA NA
FLCN cyclophosphamide 0.3374113 0.8868192 0.33741 NA NA
CD274 pazopanib 0.3383606 0.8868192 0.33836 NA NA
GNAQ afatinib 0.3383818 0.8868192 0.33838 NA NA
MYD88 azd 0.3389331 0.8868192 0.33893 NA NA
RPL10 selumetinib 0.3389406 0.8868192 0.33894 NA NA
PML imatinib 0.3392370 0.8868192 0.33924 NA NA
XPO1 fluorouracil 0.3392677 0.8868192 0.33927 NA NA
CEBPA selumetinib 0.3394672 0.8868192 0.33947 NA NA
ERBB2 selumetinib 0.3397053 0.8868192 0.33971 NA NA
CSF3R gefitinib 0.3399769 0.8868192 0.33998 NA NA
CTNNB1 afatinib 0.3404043 0.8868192 0.34040 NA NA
PAX5 ibrutinib 0.3406093 0.8868192 0.34061 NA NA
GNB1 ibrutinib 0.3413260 0.8868192 0.34133 NA NA
SRSF2 temozolomide 0.3413326 0.8868192 0.34133 NA NA
RUNX1 ruxolitinib 0.3416103 0.8868192 0.34161 NA NA
SETD2 imatinib 0.3416838 0.8868192 0.34168 NA NA
STAT3 selumetinib 0.3417326 0.8868192 0.34173 NA NA
FGFR1 crizotinib 0.3420972 0.8868192 0.34210 NA NA
ABL1 afatinib 0.3423060 0.8868192 0.34231 NA NA
IKZF1 vandetanib 0.3423478 0.8868192 0.34235 NA NA
CDK6 lapatinib 0.3424403 0.8868192 0.34244 NA NA
KRAS imatinib 0.3425829 0.8868192 0.34258 NA NA
TSC1 regorafenib 0.3430949 0.8874891 0.34309 NA NA
TET2 afatinib 0.3433771 0.8875640 0.34338 NA NA
FGFR2 temozolomide 0.3437027 0.8877509 0.34370 NA NA
ZRSR2 vandetanib 0.3441069 0.8878923 0.34411 NA NA
CD274 temozolomide 0.3449841 0.8878923 0.34498 NA NA
ESR1 nilotinib 0.3452748 0.8878923 0.34527 NA NA
TET2 selumetinib 0.3454170 0.8878923 0.34542 NA NA
NPM1 fluorouracil 0.3455604 0.8878923 0.34556 NA NA
ETV6 erlotinib 0.3458953 0.8878923 0.34590 NA NA
ETV6 ruxolitinib 0.3459053 0.8878923 0.34591 NA NA
FGFR2 trametinib 0.3461649 0.8878923 0.34616 NA NA
CALR regorafenib 0.3462390 0.8878923 0.34624 NA NA
GNAQ olaparib 0.3462907 0.8878923 0.34629 NA NA
EZH2 lapatinib 0.3465800 0.8879847 0.34658 NA NA
BRAF nilotinib 0.3473234 0.8882411 0.34732 NA NA
GNAS regorafenib 0.3474147 0.8882411 0.34741 NA NA
FGFR1 pazopanib 0.3476889 0.8882411 0.34769 NA NA
PAX8 trametinib 0.3478909 0.8882411 0.34789 NA NA
ERBB3 belinostat 0.3479934 0.8882411 0.34799 NA NA
NOTCH2 dasatinib 0.3486982 0.8882411 0.34870 NA NA
PAX5 fulvestrant 0.3494676 0.8882411 0.34947 NA NA
IKZF1 imatinib 0.3495557 0.8882411 0.34956 NA NA
BCORL1 dasatinib 0.3496889 0.8882411 0.34969 NA NA
CD79B selumetinib 0.3497566 0.8882411 0.34976 NA NA
KMT2A temozolomide 0.3497716 0.8882411 0.34977 NA NA
IDH2 cabozantinib 0.3499020 0.8882411 0.34990 NA NA
CXCR4 lapatinib 0.3499746 0.8882411 0.34997 NA NA
NPM1 neratinib 0.3504438 0.8887883 0.35044 NA NA
TSC2 afatinib 0.3514315 0.8906489 0.35143 NA NA
NRAS nilotinib 0.3521881 0.8915494 0.35219 NA NA
KRAS dasatinib 0.3522956 0.8915494 0.35230 NA NA
BCOR olaparib 0.3535476 0.8936083 0.35355 NA NA
CSF3R dasatinib 0.3536190 0.8936083 0.35362 NA NA
GNAQ fluorouracil 0.3544828 0.8949123 0.35448 NA NA
RIT1 selumetinib 0.3552063 0.8949123 0.35521 NA NA
WT1 vemurafenib 0.3553105 0.8949123 0.35531 NA NA
DDIT3 azd 0.3561125 0.8949123 0.35611 NA NA
ERBB3 cyclophosphamide 0.3561490 0.8949123 0.35615 NA NA
RUNX1 dasatinib 0.3565982 0.8949123 0.35660 NA NA
STAG2 nilotinib 0.3568363 0.8949123 0.35684 NA NA
IDH2 azd 0.3568667 0.8949123 0.35687 NA NA
PDGFB dasatinib 0.3571989 0.8949123 0.35720 NA NA
WHSC1 crizotinib 0.3576979 0.8949123 0.35770 NA NA
NPM1 dabrafenib 0.3577714 0.8949123 0.35777 NA NA
MDM2 pazopanib 0.3578286 0.8949123 0.35783 NA NA
BRAF fulvestrant 0.3578334 0.8949123 0.35783 NA NA
STAT3 pazopanib 0.3579352 0.8949123 0.35794 NA NA
TP53 belinostat 0.3581327 0.8949123 0.35813 NA NA
JAK1 olaparib 0.3582202 0.8949123 0.35822 NA NA
ALK gefitinib 0.3595266 0.8975362 0.35953 NA NA
MAP2K1 cyclophosphamide 0.3601036 0.8983367 0.36010 NA NA
FLCN belinostat 0.3607791 0.8990832 0.36078 NA NA
NPM1 temozolomide 0.3616494 0.8990832 0.36165 NA NA
PDGFB nilotinib 0.3618609 0.8990832 0.36186 NA NA
PIK3CA imatinib 0.3621148 0.8990832 0.36211 NA NA
ATM cabozantinib 0.3621986 0.8990832 0.36220 NA NA
PRPF40B selumetinib 0.3625025 0.8990832 0.36250 NA NA
RPL10 erlotinib 0.3626129 0.8990832 0.36261 NA NA
UGT1A1 temozolomide 0.3627228 0.8990832 0.36272 NA NA
MET dabrafenib 0.3629609 0.8990832 0.36296 NA NA
PDGFRB belinostat 0.3636843 0.8990832 0.36368 NA NA
GNA11 cabozantinib 0.3638083 0.8990832 0.36381 NA NA
SF1 regorafenib 0.3638431 0.8990832 0.36384 NA NA
AKT2 lapatinib 0.3638501 0.8990832 0.36385 NA NA
CREBBP afatinib 0.3642004 0.8990832 0.36420 NA NA
WT1 fulvestrant 0.3644268 0.8990832 0.36443 NA NA
PDCD1 sunitinib 0.3647275 0.8990832 0.36473 NA NA
CREBBP cyclophosphamide 0.3647636 0.8990832 0.36476 NA NA
PDCD1 belinostat 0.3664396 0.9019409 0.36644 NA NA
ERBB3 lapatinib 0.3667711 0.9019409 0.36677 NA NA
FGFR3 lapatinib 0.3671204 0.9019409 0.36712 NA NA
PDCD1 imatinib 0.3671899 0.9019409 0.36719 NA NA
ZRSR2 ibrutinib 0.3673935 0.9019409 0.36739 NA NA
WHSC1 lapatinib 0.3678242 0.9019409 0.36782 NA NA
IDH2 vemurafenib 0.3678300 0.9019409 0.36783 NA NA
TPMT regorafenib 0.3679816 0.9019409 0.36798 NA NA
PIK3CA lapatinib 0.3687598 0.9032168 0.36876 NA NA
ERBB3 azd 0.3693126 0.9034689 0.36931 NA NA
GNAS temozolomide 0.3693783 0.9034689 0.36938 NA NA
FANCL neratinib 0.3697171 0.9036670 0.36972 NA NA
BTK afatinib 0.3703680 0.9040502 0.37037 NA NA
STAG2 sunitinib 0.3704770 0.9040502 0.37048 NA NA
DNAJB1 temozolomide 0.3708368 0.9040502 0.37084 NA NA
SF1 fluorouracil 0.3710817 0.9040502 0.37108 NA NA
SF3B1 gefitinib 0.3711635 0.9040502 0.37116 NA NA
MPL nilotinib 0.3715156 0.9042793 0.37152 NA NA
CEBPA ibrutinib 0.3723726 0.9051243 0.37237 NA NA
CDC73 imatinib 0.3724289 0.9051243 0.37243 NA NA
KMT2A erlotinib 0.3727940 0.9051243 0.37279 NA NA
ATM afatinib 0.3729788 0.9051243 0.37298 NA NA
PIGA cyclophosphamide 0.3735485 0.9051243 0.37355 NA NA
JAK2 afatinib 0.3737944 0.9051243 0.37379 NA NA
CDK4 dasatinib 0.3742145 0.9051243 0.37421 NA NA
FLT3 temozolomide 0.3743174 0.9051243 0.37432 NA NA
NOTCH2 nilotinib 0.3747480 0.9051243 0.37475 NA NA
SRSF2 belinostat 0.3748446 0.9051243 0.37484 NA NA
PAX8 gefitinib 0.3749321 0.9051243 0.37493 NA NA
IDH1 azd 0.3755131 0.9051243 0.37551 NA NA
CALR imatinib 0.3755417 0.9051243 0.37554 NA NA
FANCL crizotinib 0.3757263 0.9051243 0.37573 NA NA
CTNNB1 lapatinib 0.3760276 0.9051243 0.37603 NA NA
JAK1 neratinib 0.3764130 0.9051243 0.37641 NA NA
PHF6 belinostat 0.3764443 0.9051243 0.37644 NA NA
SRSF2 ruxolitinib 0.3766348 0.9051243 0.37663 NA NA
GNAQ dabrafenib 0.3767693 0.9051243 0.37677 NA NA
CDKN2A cabozantinib 0.3771227 0.9053528 0.37712 NA NA
ROS1 cyclophosphamide 0.3774686 0.9055630 0.37747 NA NA
ABL1 ibrutinib 0.3777841 0.9056999 0.37778 NA NA
PDGFRA pazopanib 0.3783240 0.9063744 0.37832 NA NA
CTCF imatinib 0.3786740 0.9065931 0.37867 NA NA
WT1 fluorouracil 0.3800925 0.9092610 0.38009 NA NA
GATA2 fluorouracil 0.3804329 0.9092610 0.38043 NA NA
EGFR lapatinib 0.3809004 0.9092610 0.38090 NA NA
SSX1 crizotinib 0.3809940 0.9092610 0.38099 NA NA
PML sunitinib 0.3810854 0.9092610 0.38109 NA NA
BRCA2 trametinib 0.3821071 0.9106280 0.38211 NA NA
EGFR ruxolitinib 0.3825743 0.9106280 0.38257 NA NA
FGFR1 lapatinib 0.3826658 0.9106280 0.38267 NA NA
STAT3 trametinib 0.3826976 0.9106280 0.38270 NA NA
NT5C2 erlotinib 0.3832044 0.9112153 0.38320 NA NA
CREBBP fluorouracil 0.3837396 0.9116375 0.38374 NA NA
CBL lapatinib 0.3845495 0.9116375 0.38455 NA NA
GATA3 trametinib 0.3851261 0.9116375 0.38513 NA NA
NOTCH1 fluorouracil 0.3852341 0.9116375 0.38523 NA NA
SRSF2 crizotinib 0.3856349 0.9116375 0.38563 NA NA
PML dasatinib 0.3857611 0.9116375 0.38576 NA NA
WHSC1 belinostat 0.3859879 0.9116375 0.38599 NA NA
FGFR3 crizotinib 0.3860496 0.9116375 0.38605 NA NA
SMC3 cyclophosphamide 0.3860521 0.9116375 0.38605 NA NA
RUNX1 crizotinib 0.3862705 0.9116375 0.38627 NA NA
PRPF8 cyclophosphamide 0.3864459 0.9116375 0.38645 NA NA
FLCN vandetanib 0.3869061 0.9116375 0.38691 NA NA
MPL cabozantinib 0.3873750 0.9116375 0.38737 NA NA
PIK3CA olaparib 0.3882401 0.9116375 0.38824 NA NA
CTNNB1 nilotinib 0.3882687 0.9116375 0.38827 NA NA
SMO trametinib 0.3884716 0.9116375 0.38847 NA NA
NRAS cyclophosphamide 0.3886743 0.9116375 0.38867 NA NA
TP53 selumetinib 0.3892339 0.9116375 0.38923 NA NA
U2AF1 nilotinib 0.3895544 0.9116375 0.38955 NA NA
CRLF2 erlotinib 0.3896002 0.9116375 0.38960 NA NA
SETBP1 trametinib 0.3903972 0.9116375 0.39040 NA NA
CD79B cyclophosphamide 0.3905066 0.9116375 0.39051 NA NA
IKZF1 crizotinib 0.3909441 0.9116375 0.39094 NA NA
CBL erlotinib 0.3910758 0.9116375 0.39108 NA NA
BCOR sunitinib 0.3911626 0.9116375 0.39116 NA NA
ZRSR2 dasatinib 0.3912721 0.9116375 0.39127 NA NA
BCOR erlotinib 0.3920392 0.9116375 0.39204 NA NA
MGMT neratinib 0.3926360 0.9116375 0.39264 NA NA
CD79B gefitinib 0.3926440 0.9116375 0.39264 NA NA
PML afatinib 0.3926441 0.9116375 0.39264 NA NA
GNAS erlotinib 0.3930691 0.9116375 0.39307 NA NA
DDIT3 cyclophosphamide 0.3932314 0.9116375 0.39323 NA NA
BRAF cabozantinib 0.3934771 0.9116375 0.39348 NA NA
ROS1 vemurafenib 0.3937304 0.9116375 0.39373 NA NA
JAK3 vemurafenib 0.3937969 0.9116375 0.39380 NA NA
CDK6 belinostat 0.3939894 0.9116375 0.39399 NA NA
SETD2 cyclophosphamide 0.3940681 0.9116375 0.39407 NA NA
SMC1A cabozantinib 0.3941443 0.9116375 0.39414 NA NA
GATA1 dasatinib 0.3943575 0.9116375 0.39436 NA NA
CREBBP ibrutinib 0.3946184 0.9116375 0.39462 NA NA
NT5C2 vemurafenib 0.3948753 0.9116375 0.39488 NA NA
IDH1 crizotinib 0.3953310 0.9116375 0.39533 NA NA
EGF dabrafenib 0.3954019 0.9116375 0.39540 NA NA
EED afatinib 0.3954378 0.9116375 0.39544 NA NA
SF1 olaparib 0.3954598 0.9116375 0.39546 NA NA
NCOA2 vandetanib 0.3955819 0.9116375 0.39558 NA NA
SSX1 selumetinib 0.3957972 0.9116375 0.39580 NA NA
NOTCH1 olaparib 0.3959243 0.9116375 0.39592 NA NA
GATA3 ibrutinib 0.3963945 0.9116375 0.39639 NA NA
SRSF2 vemurafenib 0.3967172 0.9116375 0.39672 NA NA
ERBB3 dabrafenib 0.3967421 0.9116375 0.39674 NA NA
ETV6 sunitinib 0.3969069 0.9116375 0.39691 NA NA
ZRSR2 selumetinib 0.3972457 0.9116424 0.39725 NA NA
TPMT cyclophosphamide 0.3978413 0.9116424 0.39784 NA NA
RET belinostat 0.3979105 0.9116424 0.39791 NA NA
SF1 azd 0.3985331 0.9116424 0.39853 NA NA
CDK4 vandetanib 0.3987542 0.9116424 0.39875 NA NA
SETD2 nilotinib 0.3988856 0.9116424 0.39889 NA NA
FGFR1 selumetinib 0.3995915 0.9116424 0.39959 NA NA
KMT2A vandetanib 0.3996239 0.9116424 0.39962 NA NA
ALK dabrafenib 0.3998459 0.9116424 0.39985 NA NA
XPO1 afatinib 0.3998625 0.9116424 0.39986 NA NA
PAX5 belinostat 0.3999643 0.9116424 0.39996 NA NA
GNAQ ibrutinib 0.4001427 0.9116424 0.40014 NA NA
SSX1 ruxolitinib 0.4002903 0.9116424 0.40029 NA NA
DDIT3 cabozantinib 0.4006322 0.9116655 0.40063 NA NA
GATA3 fulvestrant 0.4010641 0.9116655 0.40106 NA NA
PDGFRA dasatinib 0.4012694 0.9116655 0.40127 NA NA
FBXW7 dabrafenib 0.4014095 0.9116655 0.40141 NA NA
WT1 erlotinib 0.4016893 0.9116655 0.40169 NA NA
GATA2 dasatinib 0.4019852 0.9116655 0.40199 NA NA
CDC73 ibrutinib 0.4024500 0.9116655 0.40245 NA NA
PRPF8 afatinib 0.4024623 0.9116655 0.40246 NA NA
SMO fulvestrant 0.4026414 0.9116655 0.40264 NA NA
ZRSR2 temozolomide 0.4031694 0.9117303 0.40317 NA NA
NPM1 vandetanib 0.4033915 0.9117303 0.40339 NA NA
EZH2 gefitinib 0.4044061 0.9117303 0.40441 NA NA
NOTCH2 imatinib 0.4046381 0.9117303 0.40464 NA NA
CTCF fulvestrant 0.4054092 0.9117303 0.40541 NA NA
CSF3R cabozantinib 0.4055136 0.9117303 0.40551 NA NA
JAK3 crizotinib 0.4057871 0.9117303 0.40579 NA NA
EED olaparib 0.4060945 0.9117303 0.40609 NA NA
FANCL vemurafenib 0.4062049 0.9117303 0.40620 NA NA
CXCR4 nilotinib 0.4068026 0.9117303 0.40680 NA NA
CREBBP trametinib 0.4073521 0.9117303 0.40735 NA NA
SETD2 ruxolitinib 0.4075290 0.9117303 0.40753 NA NA
NRAS regorafenib 0.4075483 0.9117303 0.40755 NA NA
PML ruxolitinib 0.4077983 0.9117303 0.40780 NA NA
AKT1 trametinib 0.4079935 0.9117303 0.40799 NA NA
PHF6 temozolomide 0.4087934 0.9117303 0.40879 NA NA
KMT2A fulvestrant 0.4088668 0.9117303 0.40887 NA NA
JAK1 regorafenib 0.4090809 0.9117303 0.40908 NA NA
U2AF1 azd 0.4092599 0.9117303 0.40926 NA NA
TET2 olaparib 0.4096050 0.9117303 0.40960 NA NA
KIT dabrafenib 0.4097454 0.9117303 0.40975 NA NA
DNAJB1 ibrutinib 0.4100358 0.9117303 0.41004 NA NA
GNA11 ibrutinib 0.4100358 0.9117303 0.41004 NA NA
PAX5 gefitinib 0.4102469 0.9117303 0.41025 NA NA
RET regorafenib 0.4107421 0.9117303 0.41074 NA NA
BTK erlotinib 0.4110430 0.9117303 0.41104 NA NA
ERBB3 vandetanib 0.4111293 0.9117303 0.41113 NA NA
BCORL1 cyclophosphamide 0.4111667 0.9117303 0.41117 NA NA
KRAS dabrafenib 0.4111914 0.9117303 0.41119 NA NA
IDH1 ibrutinib 0.4113763 0.9117303 0.41138 NA NA
FGFR3 vemurafenib 0.4116024 0.9117303 0.41160 NA NA
CD274 dabrafenib 0.4128908 0.9117303 0.41289 NA NA
MAP2K2 regorafenib 0.4128919 0.9117303 0.41289 NA NA
DPYD temozolomide 0.4129554 0.9117303 0.41296 NA NA
EGF neratinib 0.4133712 0.9117303 0.41337 NA NA
CALR selumetinib 0.4138553 0.9117303 0.41386 NA NA
RUNX1 gefitinib 0.4140423 0.9117303 0.41404 NA NA
CBLB selumetinib 0.4145394 0.9117303 0.41454 NA NA
FLT3 lapatinib 0.4146955 0.9117303 0.41470 NA NA
FGFR1 vemurafenib 0.4148786 0.9117303 0.41488 NA NA
ESR1 temozolomide 0.4151428 0.9117303 0.41514 NA NA
ASXL1 vandetanib 0.4151524 0.9117303 0.41515 NA NA
BRCA2 cabozantinib 0.4162945 0.9117303 0.41629 NA NA
MAP2K2 dasatinib 0.4165738 0.9117303 0.41657 NA NA
FLCN crizotinib 0.4167697 0.9117303 0.41677 NA NA
TSC2 trametinib 0.4168352 0.9117303 0.41684 NA NA
NOTCH2 olaparib 0.4168942 0.9117303 0.41689 NA NA
PML erlotinib 0.4170584 0.9117303 0.41706 NA NA
SETD2 crizotinib 0.4172206 0.9117303 0.41722 NA NA
PIK3CA trametinib 0.4175242 0.9117303 0.41752 NA NA
GNAS vandetanib 0.4177244 0.9117303 0.41772 NA NA
GATA2 neratinib 0.4177941 0.9117303 0.41779 NA NA
VHL cyclophosphamide 0.4178333 0.9117303 0.41783 NA NA
HRAS imatinib 0.4180453 0.9117303 0.41805 NA NA
DDIT3 sunitinib 0.4181226 0.9117303 0.41812 NA NA
CYP19A1 cabozantinib 0.4181415 0.9117303 0.41814 NA NA
JAK2 crizotinib 0.4182454 0.9117303 0.41825 NA NA
GATA1 pazopanib 0.4183057 0.9117303 0.41831 NA NA
CBL gefitinib 0.4183863 0.9117303 0.41839 NA NA
ALK fulvestrant 0.4191815 0.9117303 0.41918 NA NA
PTCH1 selumetinib 0.4194027 0.9117303 0.41940 NA NA
PHF6 erlotinib 0.4194250 0.9117303 0.41942 NA NA
GATA2 lapatinib 0.4194980 0.9117303 0.41950 NA NA
SF3B1 ruxolitinib 0.4195779 0.9117303 0.41958 NA NA
MAP2K1 lapatinib 0.4195780 0.9117303 0.41958 NA NA
RAD21 imatinib 0.4203182 0.9123370 0.42032 NA NA
MAP2K2 nilotinib 0.4203778 0.9123370 0.42038 NA NA
WT1 vandetanib 0.4208522 0.9128013 0.42085 NA NA
GATA3 crizotinib 0.4211317 0.9128426 0.42113 NA NA
GNA11 lapatinib 0.4215123 0.9130515 0.42151 NA NA
GATA3 vandetanib 0.4219736 0.9130515 0.42197 NA NA
SETD2 ibrutinib 0.4220095 0.9130515 0.42201 NA NA
EGFR dasatinib 0.4226734 0.9134398 0.42267 NA NA
MPL ruxolitinib 0.4233563 0.9134398 0.42336 NA NA
BRCA2 azd 0.4237037 0.9134398 0.42370 NA NA
IDH1 imatinib 0.4237378 0.9134398 0.42374 NA NA
PDCD1 ruxolitinib 0.4243351 0.9134398 0.42434 NA NA
MAP2K2 selumetinib 0.4246944 0.9134398 0.42469 NA NA
GNAS neratinib 0.4249479 0.9134398 0.42495 NA NA
IDH1 cabozantinib 0.4252881 0.9134398 0.42529 NA NA
KIT cyclophosphamide 0.4256579 0.9134398 0.42566 NA NA
DNAJB1 gefitinib 0.4257652 0.9134398 0.42577 NA NA
PAX5 olaparib 0.4260006 0.9134398 0.42600 NA NA
CEBPA trametinib 0.4265139 0.9134398 0.42651 NA NA
KMT2A lapatinib 0.4265149 0.9134398 0.42651 NA NA
GNAS pazopanib 0.4265936 0.9134398 0.42659 NA NA
GNB1 trametinib 0.4271811 0.9134398 0.42718 NA NA
GATA1 azd 0.4273208 0.9134398 0.42732 NA NA
CDKN2A regorafenib 0.4273598 0.9134398 0.42736 NA NA
SMC1A crizotinib 0.4275659 0.9134398 0.42757 NA NA
NT5C2 sunitinib 0.4275958 0.9134398 0.42760 NA NA
VHL fulvestrant 0.4278977 0.9134398 0.42790 NA NA
AKT3 fulvestrant 0.4279549 0.9134398 0.42795 NA NA
PAX8 vandetanib 0.4285175 0.9134398 0.42852 NA NA
U2AF1 vemurafenib 0.4285987 0.9134398 0.42860 NA NA
FGFR2 imatinib 0.4290355 0.9134398 0.42904 NA NA
CRLF2 cyclophosphamide 0.4291379 0.9134398 0.42914 NA NA
ESR1 ibrutinib 0.4291778 0.9134398 0.42918 NA NA
EGFR ibrutinib 0.4292255 0.9134398 0.42923 NA NA
MAP2K2 sunitinib 0.4299316 0.9139458 0.42993 NA NA
IDH1 nilotinib 0.4302393 0.9139458 0.43024 NA NA
NPM1 selumetinib 0.4302455 0.9139458 0.43025 NA NA
SMC3 vemurafenib 0.4310406 0.9146526 0.43104 NA NA
PML pazopanib 0.4313542 0.9146526 0.43135 NA NA
GATA3 gefitinib 0.4313611 0.9146526 0.43136 NA NA
CBLB fulvestrant 0.4322063 0.9152554 0.43221 NA NA
CSF3R fluorouracil 0.4326326 0.9152554 0.43263 NA NA
TPMT dabrafenib 0.4326706 0.9152554 0.43267 NA NA
PRPF8 selumetinib 0.4326899 0.9152554 0.43269 NA NA
SF3B1 vemurafenib 0.4332669 0.9158515 0.43327 NA NA
VHL trametinib 0.4334943 0.9158515 0.43349 NA NA
PDGFRB fluorouracil 0.4341969 0.9167833 0.43420 NA NA
FANCL gefitinib 0.4351949 0.9171846 0.43519 NA NA
NRAS gefitinib 0.4351967 0.9171846 0.43520 NA NA
CALR temozolomide 0.4353983 0.9171846 0.43540 NA NA
PML temozolomide 0.4354604 0.9171846 0.43546 NA NA
ESR1 cabozantinib 0.4356954 0.9171846 0.43570 NA NA
PAX8 vemurafenib 0.4362243 0.9172349 0.43622 NA NA
ERBB3 ruxolitinib 0.4364470 0.9172349 0.43645 NA NA
GNAQ sunitinib 0.4365044 0.9172349 0.43650 NA NA
MYD88 fulvestrant 0.4383092 0.9194953 0.43831 NA NA
CYP19A1 temozolomide 0.4385706 0.9194953 0.43857 NA NA
IDH2 trametinib 0.4390903 0.9194953 0.43909 NA NA
RIT1 trametinib 0.4390903 0.9194953 0.43909 NA NA
NOTCH1 vandetanib 0.4391348 0.9194953 0.43913 NA NA
TET2 cyclophosphamide 0.4396624 0.9194953 0.43966 NA NA
SETBP1 azd 0.4396679 0.9194953 0.43967 NA NA
GNB1 afatinib 0.4396874 0.9194953 0.43969 NA NA
ESR1 sunitinib 0.4399411 0.9194953 0.43994 NA NA
BRCA2 vandetanib 0.4404474 0.9199608 0.44045 NA NA
CDC73 afatinib 0.4410135 0.9199608 0.44101 NA NA
PAX5 dabrafenib 0.4414102 0.9199608 0.44141 NA NA
CTNNB1 trametinib 0.4415898 0.9199608 0.44159 NA NA
MAP2K2 pazopanib 0.4419526 0.9199608 0.44195 NA NA
CD79B vandetanib 0.4420471 0.9199608 0.44205 NA NA
CDKN2A cyclophosphamide 0.4421122 0.9199608 0.44211 NA NA
PRPF8 belinostat 0.4422636 0.9199608 0.44226 NA NA
CTNNB1 imatinib 0.4427480 0.9203925 0.44275 NA NA
WHSC1 temozolomide 0.4429963 0.9203925 0.44300 NA NA
IDH2 selumetinib 0.4434340 0.9207561 0.44343 NA NA
CRLF2 pazopanib 0.4445080 0.9216936 0.44451 NA NA
MYCN crizotinib 0.4447263 0.9216936 0.44473 NA NA
ALK nilotinib 0.4451309 0.9216936 0.44513 NA NA
PAX5 vandetanib 0.4453052 0.9216936 0.44531 NA NA
PRPF8 dabrafenib 0.4454512 0.9216936 0.44545 NA NA
PAX8 azd 0.4457725 0.9216936 0.44577 NA NA
CRLF2 cabozantinib 0.4458442 0.9216936 0.44584 NA NA
ATM pazopanib 0.4459893 0.9216936 0.44599 NA NA
CEBPA lapatinib 0.4465735 0.9222727 0.44657 NA NA
CALR trametinib 0.4467957 0.9222727 0.44680 NA NA
GATA3 dabrafenib 0.4474134 0.9230040 0.44741 NA NA
JAK3 regorafenib 0.4481858 0.9237806 0.44819 NA NA
CRLF2 gefitinib 0.4484655 0.9237806 0.44847 NA NA
GNB1 fluorouracil 0.4488380 0.9237806 0.44884 NA NA
TSC2 neratinib 0.4493579 0.9237806 0.44936 NA NA
SH2B3 ibrutinib 0.4493608 0.9237806 0.44936 NA NA
MET temozolomide 0.4496757 0.9237806 0.44968 NA NA
ASXL1 regorafenib 0.4498559 0.9237806 0.44986 NA NA
FGFR3 temozolomide 0.4502745 0.9237806 0.45027 NA NA
PDCD1 azd 0.4503246 0.9237806 0.45032 NA NA
FLCN trametinib 0.4504254 0.9237806 0.45043 NA NA
CDKN2A azd 0.4513087 0.9250508 0.45131 NA NA
FBXW7 ibrutinib 0.4529024 0.9255348 0.45290 NA NA
SMC3 sunitinib 0.4535089 0.9255348 0.45351 NA NA
AR azd 0.4540551 0.9255348 0.45406 NA NA
SMC3 afatinib 0.4544069 0.9255348 0.45441 NA NA
ASXL1 belinostat 0.4546733 0.9255348 0.45467 NA NA
ERBB3 pazopanib 0.4547800 0.9255348 0.45478 NA NA
FGFR2 regorafenib 0.4554646 0.9255348 0.45546 NA NA
IL7R olaparib 0.4555569 0.9255348 0.45556 NA NA
EED crizotinib 0.4560361 0.9255348 0.45604 NA NA
CDKN2A vemurafenib 0.4566814 0.9255348 0.45668 NA NA
FGFR2 ruxolitinib 0.4566858 0.9255348 0.45669 NA NA
SRSF2 erlotinib 0.4568633 0.9255348 0.45686 NA NA
XPO1 gefitinib 0.4568797 0.9255348 0.45688 NA NA
NOTCH2 dabrafenib 0.4572129 0.9255348 0.45721 NA NA
IDH2 dasatinib 0.4572773 0.9255348 0.45728 NA NA
ESR1 erlotinib 0.4580536 0.9255348 0.45805 NA NA
STAT3 gefitinib 0.4584552 0.9255348 0.45846 NA NA
KMT2A neratinib 0.4586028 0.9255348 0.45860 NA NA
SF3B1 nilotinib 0.4586487 0.9255348 0.45865 NA NA
HRAS dabrafenib 0.4590006 0.9255348 0.45900 NA NA
ZRSR2 olaparib 0.4592341 0.9255348 0.45923 NA NA
BRAF erlotinib 0.4592476 0.9255348 0.45925 NA NA
CBLB neratinib 0.4593277 0.9255348 0.45933 NA NA
G6PD vemurafenib 0.4602214 0.9255348 0.46022 NA NA
CSF3R temozolomide 0.4603198 0.9255348 0.46032 NA NA
U2AF1 olaparib 0.4607373 0.9255348 0.46074 NA NA
EED erlotinib 0.4608210 0.9255348 0.46082 NA NA
ESR1 vemurafenib 0.4616314 0.9255348 0.46163 NA NA
SMO erlotinib 0.4618073 0.9255348 0.46181 NA NA
BCOR gefitinib 0.4620960 0.9255348 0.46210 NA NA
BRAF vandetanib 0.4622785 0.9255348 0.46228 NA NA
PAX5 ruxolitinib 0.4625351 0.9255348 0.46254 NA NA
NOTCH2 sunitinib 0.4626037 0.9255348 0.46260 NA NA
NOTCH1 regorafenib 0.4626857 0.9255348 0.46269 NA NA
NOTCH1 azd 0.4629356 0.9255348 0.46294 NA NA
IDH1 erlotinib 0.4630798 0.9255348 0.46308 NA NA
ETV6 selumetinib 0.4631578 0.9255348 0.46316 NA NA
SMC1A neratinib 0.4636153 0.9255348 0.46362 NA NA
CDC73 vandetanib 0.4637074 0.9255348 0.46371 NA NA
GNB1 sunitinib 0.4638416 0.9255348 0.46384 NA NA
CDKN2A trametinib 0.4639190 0.9255348 0.46392 NA NA
PDGFB fluorouracil 0.4641195 0.9255348 0.46412 NA NA
MGMT sunitinib 0.4645056 0.9255348 0.46451 NA NA
SMC3 cabozantinib 0.4648918 0.9255348 0.46489 NA NA
CRLF2 sunitinib 0.4654227 0.9255348 0.46542 NA NA
JAK2 sunitinib 0.4660324 0.9255348 0.46603 NA NA
FLT3 regorafenib 0.4660591 0.9255348 0.46606 NA NA
ETV6 crizotinib 0.4661265 0.9255348 0.46613 NA NA
G6PD fluorouracil 0.4661924 0.9255348 0.46619 NA NA
ABL1 gefitinib 0.4664039 0.9255348 0.46640 NA NA
SRSF2 cabozantinib 0.4665096 0.9255348 0.46651 NA NA
CDC73 ruxolitinib 0.4667059 0.9255348 0.46671 NA NA
PIK3CA pazopanib 0.4671097 0.9255348 0.46711 NA NA
CEBPA cyclophosphamide 0.4673632 0.9255348 0.46736 NA NA
SH2B3 imatinib 0.4675138 0.9255348 0.46751 NA NA
FGFR3 erlotinib 0.4675285 0.9255348 0.46753 NA NA
GNAS cyclophosphamide 0.4676333 0.9255348 0.46763 NA NA
XPO1 ibrutinib 0.4676501 0.9255348 0.46765 NA NA
CTNNB1 pazopanib 0.4677888 0.9255348 0.46779 NA NA
AKT1 ruxolitinib 0.4679864 0.9255348 0.46799 NA NA
AR gefitinib 0.4681152 0.9255348 0.46812 NA NA
RIT1 nilotinib 0.4682565 0.9255348 0.46826 NA NA
GNAQ dasatinib 0.4691052 0.9255348 0.46911 NA NA
SSX1 dasatinib 0.4691052 0.9255348 0.46911 NA NA
CEBPA dabrafenib 0.4696707 0.9255348 0.46967 NA NA
CBLB sunitinib 0.4697197 0.9255348 0.46972 NA NA
CDK4 vemurafenib 0.4700887 0.9255348 0.47009 NA NA
ERBB4 pazopanib 0.4701323 0.9255348 0.47013 NA NA
CTCF selumetinib 0.4703252 0.9255348 0.47033 NA NA
TPMT ibrutinib 0.4703605 0.9255348 0.47036 NA NA
FGFR2 dabrafenib 0.4703617 0.9255348 0.47036 NA NA
GATA1 gefitinib 0.4710145 0.9255348 0.47101 NA NA
CSF3R regorafenib 0.4710591 0.9255348 0.47106 NA NA
NCOA2 azd 0.4710853 0.9255348 0.47109 NA NA
CTNNB1 cyclophosphamide 0.4725215 0.9269992 0.47252 NA NA
PAX8 crizotinib 0.4728356 0.9269992 0.47284 NA NA
EML4 dabrafenib 0.4729837 0.9269992 0.47298 NA NA
IKZF1 vemurafenib 0.4736493 0.9269992 0.47365 NA NA
U2AF1 fluorouracil 0.4737793 0.9269992 0.47378 NA NA
DNMT3A cabozantinib 0.4741169 0.9269992 0.47412 NA NA
ERBB2 azd 0.4751190 0.9269992 0.47512 NA NA
PAX8 cyclophosphamide 0.4756508 0.9269992 0.47565 NA NA
WT1 belinostat 0.4756747 0.9269992 0.47567 NA NA
CD274 vemurafenib 0.4757412 0.9269992 0.47574 NA NA
CYP19A1 azd 0.4757453 0.9269992 0.47575 NA NA
KIT regorafenib 0.4759780 0.9269992 0.47598 NA NA
CYP19A1 selumetinib 0.4763756 0.9269992 0.47638 NA NA
UGT1A1 fluorouracil 0.4767219 0.9269992 0.47672 NA NA
PAX5 vemurafenib 0.4768032 0.9269992 0.47680 NA NA
FGFR3 selumetinib 0.4771381 0.9269992 0.47714 NA NA
ETV6 nilotinib 0.4777851 0.9269992 0.47779 NA NA
EED lapatinib 0.4778239 0.9269992 0.47782 NA NA
BRCA2 afatinib 0.4780707 0.9269992 0.47807 NA NA
MDM2 afatinib 0.4782523 0.9269992 0.47825 NA NA
MYD88 trametinib 0.4783281 0.9269992 0.47833 NA NA
XPO1 olaparib 0.4785953 0.9269992 0.47860 NA NA
AR sunitinib 0.4786216 0.9269992 0.47862 NA NA
BRCA2 crizotinib 0.4789637 0.9269992 0.47896 NA NA
PIK3CA temozolomide 0.4791807 0.9269992 0.47918 NA NA
BRCA1 neratinib 0.4793342 0.9269992 0.47933 NA NA
MAP2K1 pazopanib 0.4793953 0.9269992 0.47940 NA NA
JAK1 lapatinib 0.4795310 0.9269992 0.47953 NA NA
SETD2 neratinib 0.4797126 0.9269992 0.47971 NA NA
CDK6 cabozantinib 0.4797651 0.9269992 0.47977 NA NA
BRCA1 imatinib 0.4803511 0.9276202 0.48035 NA NA
SSX1 neratinib 0.4812085 0.9278467 0.48121 NA NA
G6PD dasatinib 0.4813514 0.9278467 0.48135 NA NA
NOTCH1 belinostat 0.4814267 0.9278467 0.48143 NA NA
EGFR dabrafenib 0.4817681 0.9278467 0.48177 NA NA
JAK2 trametinib 0.4825043 0.9278467 0.48250 NA NA
G6PD lapatinib 0.4825811 0.9278467 0.48258 NA NA
IDH2 pazopanib 0.4829493 0.9278467 0.48295 NA NA
ABL1 selumetinib 0.4835135 0.9278467 0.48351 NA NA
MGMT belinostat 0.4836415 0.9278467 0.48364 NA NA
BRCA2 belinostat 0.4837494 0.9278467 0.48375 NA NA
DDIT3 ibrutinib 0.4844242 0.9278467 0.48442 NA NA
FLT3 belinostat 0.4844586 0.9278467 0.48446 NA NA
AR erlotinib 0.4846917 0.9278467 0.48469 NA NA
CBL azd 0.4848329 0.9278467 0.48483 NA NA
BRCA1 fluorouracil 0.4849343 0.9278467 0.48493 NA NA
SSX1 lapatinib 0.4855081 0.9278467 0.48551 NA NA
ASXL1 lapatinib 0.4855460 0.9278467 0.48555 NA NA
PTPN11 dasatinib 0.4856387 0.9278467 0.48564 NA NA
CSF3R belinostat 0.4857383 0.9278467 0.48574 NA NA
NCOA2 crizotinib 0.4858215 0.9278467 0.48582 NA NA
PTPN11 afatinib 0.4862945 0.9278467 0.48629 NA NA
PDCD1 dabrafenib 0.4870789 0.9278467 0.48708 NA NA
DNMT3A temozolomide 0.4872219 0.9278467 0.48722 NA NA
ALK regorafenib 0.4873433 0.9278467 0.48734 NA NA
ATM lapatinib 0.4875162 0.9278467 0.48752 NA NA
U2AF1 vandetanib 0.4876100 0.9278467 0.48761 NA NA
DPYD ruxolitinib 0.4879108 0.9278467 0.48791 NA NA
EZH2 selumetinib 0.4883319 0.9278467 0.48833 NA NA
BTK cyclophosphamide 0.4883778 0.9278467 0.48838 NA NA
BCOR vandetanib 0.4890624 0.9278467 0.48906 NA NA
CD274 belinostat 0.4892836 0.9278467 0.48928 NA NA
DNAJB1 regorafenib 0.4897697 0.9278467 0.48977 NA NA
MET afatinib 0.4898065 0.9278467 0.48981 NA NA
SH2B3 afatinib 0.4899403 0.9278467 0.48994 NA NA
WHSC1 regorafenib 0.4899992 0.9278467 0.49000 NA NA
RPL10 lapatinib 0.4900257 0.9278467 0.49003 NA NA
PDGFRA neratinib 0.4902631 0.9278467 0.49026 NA NA
GNAQ ruxolitinib 0.4905906 0.9279655 0.49059 NA NA
RUNX1 pazopanib 0.4925311 0.9307389 0.49253 NA NA
CDK4 temozolomide 0.4927602 0.9307389 0.49276 NA NA
FBXW7 trametinib 0.4930321 0.9307389 0.49303 NA NA
BCORL1 lapatinib 0.4933397 0.9307389 0.49334 NA NA
DNAJB1 selumetinib 0.4936501 0.9307389 0.49365 NA NA
MGMT crizotinib 0.4938707 0.9307389 0.49387 NA NA
RIT1 lapatinib 0.4944175 0.9307389 0.49442 NA NA
SF3B1 ibrutinib 0.4946447 0.9307389 0.49464 NA NA
SH2B3 vemurafenib 0.4946802 0.9307389 0.49468 NA NA
PRPF8 vandetanib 0.4948851 0.9307389 0.49489 NA NA
TSC1 vandetanib 0.4950385 0.9307389 0.49504 NA NA
DPYD lapatinib 0.4952434 0.9307389 0.49524 NA NA
GNA11 afatinib 0.4958414 0.9310349 0.49584 NA NA
SMC1A olaparib 0.4960568 0.9310349 0.49606 NA NA
GATA1 vemurafenib 0.4961978 0.9310349 0.49620 NA NA
SETBP1 nilotinib 0.4965845 0.9312236 0.49658 NA NA
PTCH1 pazopanib 0.4968297 0.9312236 0.49683 NA NA
PRPF8 dasatinib 0.4974984 0.9319785 0.49750 NA NA
STAG2 vandetanib 0.4981905 0.9327766 0.49819 NA NA
EED temozolomide 0.4985623 0.9329744 0.49856 NA NA
EED regorafenib 0.4993179 0.9332424 0.49932 NA NA
ERBB4 afatinib 0.4994235 0.9332424 0.49942 NA NA
CDK6 gefitinib 0.4995044 0.9332424 0.49950 NA NA
IL7R ibrutinib 0.5005914 0.9347751 0.50059 NA NA
SETBP1 cabozantinib 0.5016169 0.9353377 0.50162 NA NA
ASXL1 trametinib 0.5016499 0.9353377 0.50165 NA NA
PTPN11 olaparib 0.5016933 0.9353377 0.50169 NA NA
BTK regorafenib 0.5020376 0.9354821 0.50204 NA NA
CD274 cabozantinib 0.5026289 0.9360862 0.50263 NA NA
TSC1 temozolomide 0.5032091 0.9362097 0.50321 NA NA
EGF azd 0.5032808 0.9362097 0.50328 NA NA
SH2B3 dabrafenib 0.5040226 0.9362097 0.50402 NA NA
GNAS olaparib 0.5040697 0.9362097 0.50407 NA NA
DPYD cyclophosphamide 0.5045811 0.9362097 0.50458 NA NA
NOTCH2 fluorouracil 0.5047894 0.9362097 0.50479 NA NA
WT1 ibrutinib 0.5054016 0.9362097 0.50540 NA NA
CBL trametinib 0.5054059 0.9362097 0.50541 NA NA
SETD2 dabrafenib 0.5055253 0.9362097 0.50553 NA NA
SMC1A selumetinib 0.5061254 0.9362097 0.50613 NA NA
STAG2 afatinib 0.5067070 0.9362097 0.50671 NA NA
SMC3 nilotinib 0.5067861 0.9362097 0.50679 NA NA
IL7R dabrafenib 0.5068744 0.9362097 0.50687 NA NA
ASXL1 pazopanib 0.5069058 0.9362097 0.50691 NA NA
CTLA4 sunitinib 0.5069426 0.9362097 0.50694 NA NA
CALR lapatinib 0.5069689 0.9362097 0.50697 NA NA
CSF3R afatinib 0.5086090 0.9387438 0.50861 NA NA
IKZF1 trametinib 0.5091759 0.9390581 0.50918 NA NA
MAP2K2 ibrutinib 0.5093151 0.9390581 0.50932 NA NA
IL7R vandetanib 0.5102205 0.9393471 0.51022 NA NA
AR neratinib 0.5105201 0.9393471 0.51052 NA NA
CBL regorafenib 0.5115246 0.9393471 0.51152 NA NA
NOTCH1 pazopanib 0.5116110 0.9393471 0.51161 NA NA
RET sunitinib 0.5118218 0.9393471 0.51182 NA NA
CDC73 olaparib 0.5122274 0.9393471 0.51223 NA NA
DPYD trametinib 0.5123073 0.9393471 0.51231 NA NA
UGT1A1 trametinib 0.5123562 0.9393471 0.51236 NA NA
WHSC1 afatinib 0.5124593 0.9393471 0.51246 NA NA
FANCL azd 0.5129228 0.9393471 0.51292 NA NA
CD79B neratinib 0.5130945 0.9393471 0.51309 NA NA
PML lapatinib 0.5131940 0.9393471 0.51319 NA NA
ZRSR2 cyclophosphamide 0.5133998 0.9393471 0.51340 NA NA
SMC1A fulvestrant 0.5136425 0.9393471 0.51364 NA NA
STAG2 ibrutinib 0.5139402 0.9393471 0.51394 NA NA
NRAS fulvestrant 0.5139936 0.9393471 0.51399 NA NA
WHSC1 fulvestrant 0.5140279 0.9393471 0.51403 NA NA
DDIT3 neratinib 0.5143581 0.9394607 0.51436 NA NA
GNB1 cyclophosphamide 0.5150699 0.9402708 0.51507 NA NA
NCOA2 afatinib 0.5161837 0.9402792 0.51618 NA NA
RIT1 cyclophosphamide 0.5164134 0.9402792 0.51641 NA NA
BCOR afatinib 0.5167157 0.9402792 0.51672 NA NA
U2AF1 afatinib 0.5168031 0.9402792 0.51680 NA NA
MET neratinib 0.5169277 0.9402792 0.51693 NA NA
RET pazopanib 0.5175936 0.9402792 0.51759 NA NA
TSC2 ruxolitinib 0.5176922 0.9402792 0.51769 NA NA
DPYD dabrafenib 0.5177549 0.9402792 0.51775 NA NA
NOTCH1 temozolomide 0.5178042 0.9402792 0.51780 NA NA
MAP2K2 azd 0.5179526 0.9402792 0.51795 NA NA
BRCA1 gefitinib 0.5187110 0.9402792 0.51871 NA NA
PDGFRA nilotinib 0.5194411 0.9402792 0.51944 NA NA
FGFR2 sunitinib 0.5196058 0.9402792 0.51961 NA NA
ABL1 regorafenib 0.5196255 0.9402792 0.51963 NA NA
ATM fulvestrant 0.5202454 0.9402792 0.52025 NA NA
U2AF1 sunitinib 0.5205839 0.9402792 0.52058 NA NA
AKT3 trametinib 0.5207009 0.9402792 0.52070 NA NA
CDK4 crizotinib 0.5207399 0.9402792 0.52074 NA NA
RIT1 cabozantinib 0.5210929 0.9402792 0.52109 NA NA
IKZF1 neratinib 0.5215096 0.9402792 0.52151 NA NA
CBLB cyclophosphamide 0.5219882 0.9402792 0.52199 NA NA
STAT3 temozolomide 0.5221724 0.9402792 0.52217 NA NA
NPM1 gefitinib 0.5229480 0.9402792 0.52295 NA NA
SF1 belinostat 0.5231187 0.9402792 0.52312 NA NA
GNB1 vemurafenib 0.5232772 0.9402792 0.52328 NA NA
DPYD regorafenib 0.5244529 0.9402792 0.52445 NA NA
CTCF neratinib 0.5245165 0.9402792 0.52452 NA NA
NCOA2 cyclophosphamide 0.5245474 0.9402792 0.52455 NA NA
MYCN ibrutinib 0.5250844 0.9402792 0.52508 NA NA
FGFR3 dabrafenib 0.5253814 0.9402792 0.52538 NA NA
PAX8 fulvestrant 0.5259576 0.9402792 0.52596 NA NA
MPL trametinib 0.5260170 0.9402792 0.52602 NA NA
FBXW7 cabozantinib 0.5263715 0.9402792 0.52637 NA NA
FLCN dasatinib 0.5272924 0.9402792 0.52729 NA NA
FGFR3 ibrutinib 0.5276402 0.9402792 0.52764 NA NA
AKT2 temozolomide 0.5277255 0.9402792 0.52773 NA NA
ZRSR2 ruxolitinib 0.5278655 0.9402792 0.52787 NA NA
BRCA2 olaparib 0.5281161 0.9402792 0.52812 NA NA
FGFR3 pazopanib 0.5287975 0.9402792 0.52880 NA NA
CDKN2A vandetanib 0.5289686 0.9402792 0.52897 NA NA
ETV6 ibrutinib 0.5289813 0.9402792 0.52898 NA NA
DNMT3A nilotinib 0.5289852 0.9402792 0.52899 NA NA
FLCN regorafenib 0.5296745 0.9402792 0.52967 NA NA
PDCD1 pazopanib 0.5298328 0.9402792 0.52983 NA NA
MYCN pazopanib 0.5299508 0.9402792 0.52995 NA NA
HRAS temozolomide 0.5303032 0.9402792 0.53030 NA NA
AKT1 cyclophosphamide 0.5303222 0.9402792 0.53032 NA NA
PDGFRA ruxolitinib 0.5303811 0.9402792 0.53038 NA NA
FGFR3 nilotinib 0.5306141 0.9402792 0.53061 NA NA
RIT1 vemurafenib 0.5306802 0.9402792 0.53068 NA NA
SMC3 vandetanib 0.5307791 0.9402792 0.53078 NA NA
FGFR1 ruxolitinib 0.5310554 0.9402792 0.53106 NA NA
DNAJB1 vemurafenib 0.5316009 0.9402792 0.53160 NA NA
MDM2 dasatinib 0.5317965 0.9402792 0.53180 NA NA
RAD21 nilotinib 0.5318933 0.9402792 0.53189 NA NA
KIT sunitinib 0.5322976 0.9402792 0.53230 NA NA
CREBBP olaparib 0.5325820 0.9402792 0.53258 NA NA
SETBP1 belinostat 0.5325831 0.9402792 0.53258 NA NA
RAD21 belinostat 0.5327061 0.9402792 0.53271 NA NA
PDCD1 gefitinib 0.5327619 0.9402792 0.53276 NA NA
JAK3 fulvestrant 0.5327807 0.9402792 0.53278 NA NA
SMO belinostat 0.5328601 0.9402792 0.53286 NA NA
NOTCH1 dasatinib 0.5329670 0.9402792 0.53297 NA NA
FLCN selumetinib 0.5330953 0.9402792 0.53310 NA NA
FLT3 dasatinib 0.5331194 0.9402792 0.53312 NA NA
SMO gefitinib 0.5331898 0.9402792 0.53319 NA NA
NRAS olaparib 0.5332603 0.9402792 0.53326 NA NA
PTPN11 cyclophosphamide 0.5334607 0.9402792 0.53346 NA NA
JAK1 gefitinib 0.5335975 0.9402792 0.53360 NA NA
SH2B3 cabozantinib 0.5342347 0.9402792 0.53423 NA NA
SF3B1 fulvestrant 0.5343453 0.9402792 0.53435 NA NA
NOTCH1 ruxolitinib 0.5348704 0.9402792 0.53487 NA NA
DDIT3 pazopanib 0.5350110 0.9402792 0.53501 NA NA
PIK3CA nilotinib 0.5354677 0.9402792 0.53547 NA NA
PRPF8 fluorouracil 0.5356521 0.9402792 0.53565 NA NA
G6PD cyclophosphamide 0.5360224 0.9402792 0.53602 NA NA
ERBB3 crizotinib 0.5361343 0.9402792 0.53613 NA NA
BTK vandetanib 0.5361848 0.9402792 0.53618 NA NA
FGFR3 afatinib 0.5362677 0.9402792 0.53627 NA NA
TET2 temozolomide 0.5366331 0.9404495 0.53663 NA NA
IL7R crizotinib 0.5372087 0.9407803 0.53721 NA NA
GNAQ nilotinib 0.5373587 0.9407803 0.53736 NA NA
NOTCH2 cabozantinib 0.5382614 0.9418902 0.53826 NA NA
MYD88 imatinib 0.5393201 0.9426638 0.53932 NA NA
TSC1 lapatinib 0.5398720 0.9426638 0.53987 NA NA
CTNNB1 sunitinib 0.5402849 0.9426638 0.54028 NA NA
STAG2 azd 0.5404441 0.9426638 0.54044 NA NA
RET vemurafenib 0.5409337 0.9426638 0.54093 NA NA
ATM olaparib 0.5410315 0.9426638 0.54103 NA NA
GATA3 azd 0.5411533 0.9426638 0.54115 NA NA
NOTCH1 lapatinib 0.5415351 0.9426638 0.54154 NA NA
CDKN2A gefitinib 0.5418616 0.9426638 0.54186 NA NA
BRCA2 dabrafenib 0.5419188 0.9426638 0.54192 NA NA
FGFR3 olaparib 0.5420962 0.9426638 0.54210 NA NA
XPO1 ruxolitinib 0.5421362 0.9426638 0.54214 NA NA
MAP2K2 cyclophosphamide 0.5425123 0.9426638 0.54251 NA NA
TSC2 crizotinib 0.5427013 0.9426638 0.54270 NA NA
PTCH1 fulvestrant 0.5427377 0.9426638 0.54274 NA NA
SF1 gefitinib 0.5435458 0.9435999 0.54355 NA NA
BRCA2 cyclophosphamide 0.5442614 0.9439587 0.54426 NA NA
TP53 vandetanib 0.5443709 0.9439587 0.54437 NA NA
NPM1 nilotinib 0.5448245 0.9439587 0.54482 NA NA
AR selumetinib 0.5450963 0.9439587 0.54510 NA NA
SH2B3 regorafenib 0.5450991 0.9439587 0.54510 NA NA
TET2 dabrafenib 0.5455143 0.9439718 0.54551 NA NA
AKT3 crizotinib 0.5462479 0.9439718 0.54625 NA NA
CDK6 nilotinib 0.5465693 0.9439718 0.54657 NA NA
RPL10 azd 0.5472348 0.9439718 0.54723 NA NA
EGFR erlotinib 0.5472418 0.9439718 0.54724 NA NA
EGFR nilotinib 0.5479716 0.9439718 0.54797 NA NA
ESR1 regorafenib 0.5481555 0.9439718 0.54816 NA NA
CBL dasatinib 0.5483351 0.9439718 0.54834 NA NA
TSC2 erlotinib 0.5491647 0.9439718 0.54916 NA NA
EZH2 ibrutinib 0.5491654 0.9439718 0.54917 NA NA
AR vemurafenib 0.5492099 0.9439718 0.54921 NA NA
PAX8 sunitinib 0.5497315 0.9439718 0.54973 NA NA
RUNX1 dabrafenib 0.5500761 0.9439718 0.55008 NA NA
ATM azd 0.5513285 0.9439718 0.55133 NA NA
ERBB3 selumetinib 0.5514235 0.9439718 0.55142 NA NA
MGMT azd 0.5517454 0.9439718 0.55175 NA NA
PAX8 ruxolitinib 0.5518605 0.9439718 0.55186 NA NA
TSC2 temozolomide 0.5520727 0.9439718 0.55207 NA NA
MYD88 neratinib 0.5522299 0.9439718 0.55223 NA NA
JAK2 dabrafenib 0.5524829 0.9439718 0.55248 NA NA
PAX5 erlotinib 0.5529821 0.9439718 0.55298 NA NA
GNAS sunitinib 0.5536865 0.9439718 0.55369 NA NA
SMO temozolomide 0.5540279 0.9439718 0.55403 NA NA
GNA11 imatinib 0.5547601 0.9439718 0.55476 NA NA
CD274 azd 0.5551244 0.9439718 0.55512 NA NA
CD79B fulvestrant 0.5551558 0.9439718 0.55516 NA NA
U2AF1 temozolomide 0.5555499 0.9439718 0.55555 NA NA
EED neratinib 0.5557457 0.9439718 0.55575 NA NA
IDH2 ruxolitinib 0.5558028 0.9439718 0.55580 NA NA
PDGFRB fulvestrant 0.5559160 0.9439718 0.55592 NA NA
PDGFB gefitinib 0.5559298 0.9439718 0.55593 NA NA
GATA1 crizotinib 0.5559684 0.9439718 0.55597 NA NA
JAK1 dabrafenib 0.5564198 0.9439718 0.55642 NA NA
EED fluorouracil 0.5569099 0.9439718 0.55691 NA NA
PRPF8 crizotinib 0.5571369 0.9439718 0.55714 NA NA
SH2B3 lapatinib 0.5575143 0.9439718 0.55751 NA NA
CTNNB1 olaparib 0.5575229 0.9439718 0.55752 NA NA
ERBB2 vemurafenib 0.5578381 0.9439718 0.55784 NA NA
CD79B pazopanib 0.5581185 0.9439718 0.55812 NA NA
WT1 azd 0.5582167 0.9439718 0.55822 NA NA
ZRSR2 vemurafenib 0.5582444 0.9439718 0.55824 NA NA
TET2 crizotinib 0.5583494 0.9439718 0.55835 NA NA
U2AF1 erlotinib 0.5590181 0.9439718 0.55902 NA NA
SETD2 pazopanib 0.5598273 0.9439718 0.55983 NA NA
TSC2 vandetanib 0.5599331 0.9439718 0.55993 NA NA
SMO afatinib 0.5600384 0.9439718 0.56004 NA NA
ERBB2 vandetanib 0.5606927 0.9439718 0.56069 NA NA
SSX1 belinostat 0.5609854 0.9439718 0.56099 NA NA
STAT3 nilotinib 0.5611889 0.9439718 0.56119 NA NA
PDGFRB nilotinib 0.5622570 0.9439718 0.56226 NA NA
MYCN fluorouracil 0.5625227 0.9439718 0.56252 NA NA
AKT2 neratinib 0.5626464 0.9439718 0.56265 NA NA
U2AF1 cyclophosphamide 0.5627586 0.9439718 0.56276 NA NA
IKZF1 olaparib 0.5637986 0.9439718 0.56380 NA NA
PDCD1 vandetanib 0.5638282 0.9439718 0.56383 NA NA
NRAS fluorouracil 0.5640895 0.9439718 0.56409 NA NA
FGFR1 erlotinib 0.5641627 0.9439718 0.56416 NA NA
DNAJB1 sunitinib 0.5641677 0.9439718 0.56417 NA NA
IL7R lapatinib 0.5643909 0.9439718 0.56439 NA NA
CDK6 fluorouracil 0.5643997 0.9439718 0.56440 NA NA
BCORL1 selumetinib 0.5646517 0.9439718 0.56465 NA NA
STAT3 crizotinib 0.5651302 0.9439718 0.56513 NA NA
U2AF1 cabozantinib 0.5653347 0.9439718 0.56533 NA NA
PAX8 dabrafenib 0.5654873 0.9439718 0.56549 NA NA
TET2 fluorouracil 0.5663106 0.9439718 0.56631 NA NA
XPO1 trametinib 0.5663317 0.9439718 0.56633 NA NA
CTNNB1 neratinib 0.5673863 0.9439718 0.56739 NA NA
STAT3 vemurafenib 0.5675042 0.9439718 0.56750 NA NA
MAP2K1 neratinib 0.5675322 0.9439718 0.56753 NA NA
IL7R ruxolitinib 0.5675484 0.9439718 0.56755 NA NA
SMO ruxolitinib 0.5675527 0.9439718 0.56755 NA NA
GNAQ regorafenib 0.5675838 0.9439718 0.56758 NA NA
GATA2 dabrafenib 0.5679266 0.9439718 0.56793 NA NA
STAT3 sunitinib 0.5679662 0.9439718 0.56797 NA NA
CBL olaparib 0.5684804 0.9439718 0.56848 NA NA
JAK2 ibrutinib 0.5688103 0.9439718 0.56881 NA NA
RET fulvestrant 0.5689282 0.9439718 0.56893 NA NA
ZRSR2 fulvestrant 0.5690843 0.9439718 0.56908 NA NA
BTK neratinib 0.5692234 0.9439718 0.56922 NA NA
CDKN2A erlotinib 0.5693316 0.9439718 0.56933 NA NA
NOTCH2 vemurafenib 0.5698987 0.9439718 0.56990 NA NA
MGMT olaparib 0.5699313 0.9439718 0.56993 NA NA
SH2B3 temozolomide 0.5700519 0.9439718 0.57005 NA NA
SMC1A nilotinib 0.5706209 0.9439718 0.57062 NA NA
PDGFB olaparib 0.5706892 0.9439718 0.57069 NA NA
MAP2K1 temozolomide 0.5710964 0.9439718 0.57110 NA NA
GNAQ cyclophosphamide 0.5711972 0.9439718 0.57120 NA NA
FLT3 fulvestrant 0.5722357 0.9439718 0.57224 NA NA
MPL vemurafenib 0.5734209 0.9439718 0.57342 NA NA
NCOA2 imatinib 0.5735089 0.9439718 0.57351 NA NA
CEBPA vandetanib 0.5735805 0.9439718 0.57358 NA NA
SH2B3 trametinib 0.5743914 0.9439718 0.57439 NA NA
U2AF1 trametinib 0.5743914 0.9439718 0.57439 NA NA
IDH1 sunitinib 0.5752268 0.9439718 0.57523 NA NA
BCORL1 crizotinib 0.5765314 0.9439718 0.57653 NA NA
SETD2 regorafenib 0.5770596 0.9439718 0.57706 NA NA
KRAS cyclophosphamide 0.5770737 0.9439718 0.57707 NA NA
PML belinostat 0.5778444 0.9439718 0.57784 NA NA
MAP2K1 olaparib 0.5778533 0.9439718 0.57785 NA NA
FANCL olaparib 0.5779965 0.9439718 0.57800 NA NA
PDGFRB gefitinib 0.5781143 0.9439718 0.57811 NA NA
SH2B3 fulvestrant 0.5781176 0.9439718 0.57812 NA NA
BCOR fulvestrant 0.5781760 0.9439718 0.57818 NA NA
DPYD sunitinib 0.5784482 0.9439718 0.57845 NA NA
SETD2 cabozantinib 0.5786852 0.9439718 0.57869 NA NA
GNB1 ruxolitinib 0.5787520 0.9439718 0.57875 NA NA
MYD88 pazopanib 0.5788620 0.9439718 0.57886 NA NA
PRPF40B cyclophosphamide 0.5796414 0.9439718 0.57964 NA NA
BTK ruxolitinib 0.5797617 0.9439718 0.57976 NA NA
MPL regorafenib 0.5803078 0.9439718 0.58031 NA NA
FANCL dabrafenib 0.5804329 0.9439718 0.58043 NA NA
RAD21 sunitinib 0.5805152 0.9439718 0.58052 NA NA
TP53 ruxolitinib 0.5806922 0.9439718 0.58069 NA NA
WT1 nilotinib 0.5807610 0.9439718 0.58076 NA NA
SMO pazopanib 0.5808466 0.9439718 0.58085 NA NA
TP53 lapatinib 0.5810293 0.9439718 0.58103 NA NA
UGT1A1 afatinib 0.5812670 0.9439718 0.58127 NA NA
CSF3R cyclophosphamide 0.5812996 0.9439718 0.58130 NA NA
MAP2K2 belinostat 0.5817736 0.9439718 0.58177 NA NA
ABL1 imatinib 0.5818558 0.9439718 0.58186 NA NA
CBL cyclophosphamide 0.5820601 0.9439718 0.58206 NA NA
JAK3 nilotinib 0.5820909 0.9439718 0.58209 NA NA
SF3B1 erlotinib 0.5821367 0.9439718 0.58214 NA NA
FLT3 imatinib 0.5821546 0.9439718 0.58215 NA NA
CTCF crizotinib 0.5823874 0.9439718 0.58239 NA NA
GATA3 olaparib 0.5824076 0.9439718 0.58241 NA NA
ERBB3 nilotinib 0.5829246 0.9439718 0.58292 NA NA
JAK3 pazopanib 0.5834963 0.9439718 0.58350 NA NA
FGFR1 afatinib 0.5840901 0.9439718 0.58409 NA NA
CDK6 olaparib 0.5843079 0.9439718 0.58431 NA NA
DNMT3A cyclophosphamide 0.5843537 0.9439718 0.58435 NA NA
BTK azd 0.5845687 0.9439718 0.58457 NA NA
PHF6 neratinib 0.5847037 0.9439718 0.58470 NA NA
CALR dasatinib 0.5847504 0.9439718 0.58475 NA NA
PML cabozantinib 0.5847529 0.9439718 0.58475 NA NA
PRPF40B dasatinib 0.5848789 0.9439718 0.58488 NA NA
NOTCH1 crizotinib 0.5851495 0.9439718 0.58515 NA NA
TP53 neratinib 0.5853550 0.9439718 0.58536 NA NA
SRSF2 regorafenib 0.5854363 0.9439718 0.58544 NA NA
WT1 cyclophosphamide 0.5856825 0.9439718 0.58568 NA NA
GATA3 neratinib 0.5858586 0.9439718 0.58586 NA NA
SETD2 sunitinib 0.5862419 0.9439718 0.58624 NA NA
EML4 gefitinib 0.5864377 0.9439718 0.58644 NA NA
TET2 neratinib 0.5867138 0.9439718 0.58671 NA NA
AKT3 azd 0.5867560 0.9439718 0.58676 NA NA
RAD21 crizotinib 0.5870720 0.9439718 0.58707 NA NA
CXCR4 selumetinib 0.5872055 0.9439718 0.58721 NA NA
GATA1 fluorouracil 0.5872632 0.9439718 0.58726 NA NA
ZRSR2 crizotinib 0.5873715 0.9439718 0.58737 NA NA
MPL vandetanib 0.5876287 0.9439718 0.58763 NA NA
SMC3 lapatinib 0.5876365 0.9439718 0.58764 NA NA
ROS1 belinostat 0.5877641 0.9439718 0.58776 NA NA
FGFR1 ibrutinib 0.5881332 0.9439718 0.58813 NA NA
AKT1 temozolomide 0.5884213 0.9439718 0.58842 NA NA
KIT lapatinib 0.5885275 0.9439718 0.58853 NA NA
CTNNB1 cabozantinib 0.5892427 0.9439718 0.58924 NA NA
GNB1 erlotinib 0.5892431 0.9439718 0.58924 NA NA
MAP2K1 fluorouracil 0.5893340 0.9439718 0.58933 NA NA
NCOA2 gefitinib 0.5894485 0.9439718 0.58945 NA NA
ERBB3 fulvestrant 0.5897197 0.9439718 0.58972 NA NA
CREBBP dabrafenib 0.5898748 0.9439718 0.58987 NA NA
STAT3 neratinib 0.5899191 0.9439718 0.58992 NA NA
IL7R erlotinib 0.5900249 0.9439718 0.59002 NA NA
MDM2 erlotinib 0.5904307 0.9439718 0.59043 NA NA
PIGA ibrutinib 0.5914515 0.9439718 0.59145 NA NA
CREBBP temozolomide 0.5922228 0.9439718 0.59222 NA NA
SF1 ibrutinib 0.5922909 0.9439718 0.59229 NA NA
NOTCH1 imatinib 0.5925381 0.9439718 0.59254 NA NA
AR afatinib 0.5928043 0.9439718 0.59280 NA NA
KIT azd 0.5928965 0.9439718 0.59290 NA NA
PTEN fulvestrant 0.5928983 0.9439718 0.59290 NA NA
CD274 dasatinib 0.5930913 0.9439718 0.59309 NA NA
NCOA2 ruxolitinib 0.5931302 0.9439718 0.59313 NA NA
BTK trametinib 0.5932755 0.9439718 0.59328 NA NA
JAK1 belinostat 0.5933111 0.9439718 0.59331 NA NA
CRLF2 dasatinib 0.5935835 0.9439718 0.59358 NA NA
TET2 vandetanib 0.5936187 0.9439718 0.59362 NA NA
ASXL1 crizotinib 0.5936541 0.9439718 0.59365 NA NA
IKZF1 erlotinib 0.5937279 0.9439718 0.59373 NA NA
EED vemurafenib 0.5938903 0.9439718 0.59389 NA NA
GATA1 selumetinib 0.5940691 0.9439718 0.59407 NA NA
NOTCH1 trametinib 0.5941232 0.9439718 0.59412 NA NA
PDGFRB temozolomide 0.5946643 0.9444034 0.59466 NA NA
PAX5 sunitinib 0.5950463 0.9445821 0.59505 NA NA
SF1 lapatinib 0.5955219 0.9449092 0.59552 NA NA
FGFR1 nilotinib 0.5959299 0.9451287 0.59593 NA NA
PRPF40B vemurafenib 0.5974261 0.9470731 0.59743 NA NA
PIGA selumetinib 0.5988009 0.9476659 0.59880 NA NA
NRAS dabrafenib 0.5989560 0.9476659 0.59896 NA NA
DPYD cabozantinib 0.5989674 0.9476659 0.59897 NA NA
GATA1 afatinib 0.5992718 0.9476659 0.59927 NA NA
PAX5 selumetinib 0.5992871 0.9476659 0.59929 NA NA
ATM nilotinib 0.5994224 0.9476659 0.59942 NA NA
EML4 azd 0.6000011 0.9479822 0.60000 NA NA
CTLA4 nilotinib 0.6001633 0.9479822 0.60016 NA NA
NT5C2 ibrutinib 0.6005938 0.9482348 0.60059 NA NA
ERBB4 cyclophosphamide 0.6013206 0.9484578 0.60132 NA NA
SF1 ruxolitinib 0.6017314 0.9484578 0.60173 NA NA
CD274 lapatinib 0.6020040 0.9484578 0.60200 NA NA
NT5C2 fulvestrant 0.6021476 0.9484578 0.60215 NA NA
TET2 belinostat 0.6023459 0.9484578 0.60235 NA NA
G6PD ibrutinib 0.6023586 0.9484578 0.60236 NA NA
STAT3 cyclophosphamide 0.6028017 0.9485153 0.60280 NA NA
RUNX1 lapatinib 0.6029364 0.9485153 0.60294 NA NA
PIGA vandetanib 0.6041903 0.9491582 0.60419 NA NA
HRAS nilotinib 0.6043473 0.9491582 0.60435 NA NA
SH2B3 cyclophosphamide 0.6046266 0.9491582 0.60463 NA NA
JAK1 trametinib 0.6047835 0.9491582 0.60478 NA NA
XPO1 neratinib 0.6049084 0.9491582 0.60491 NA NA
XPO1 azd 0.6049699 0.9491582 0.60497 NA NA
DNMT3A vemurafenib 0.6061305 0.9496346 0.60613 NA NA
PDCD1 ibrutinib 0.6070878 0.9496346 0.60709 NA NA
MET azd 0.6072926 0.9496346 0.60729 NA NA
DNAJB1 belinostat 0.6075884 0.9496346 0.60759 NA NA
MAP2K1 vandetanib 0.6076938 0.9496346 0.60769 NA NA
GNA11 sunitinib 0.6077823 0.9496346 0.60778 NA NA
VHL ibrutinib 0.6081955 0.9496346 0.60820 NA NA
G6PD azd 0.6083192 0.9496346 0.60832 NA NA
STAG2 ruxolitinib 0.6085848 0.9496346 0.60858 NA NA
MGMT cyclophosphamide 0.6089169 0.9496346 0.60892 NA NA
RET cabozantinib 0.6089852 0.9496346 0.60899 NA NA
NT5C2 selumetinib 0.6090924 0.9496346 0.60909 NA NA
BCOR pazopanib 0.6091276 0.9496346 0.60913 NA NA
SMC3 regorafenib 0.6092466 0.9496346 0.60925 NA NA
ERBB4 belinostat 0.6093376 0.9496346 0.60934 NA NA
CD274 afatinib 0.6100780 0.9500645 0.61008 NA NA
MAP2K1 imatinib 0.6104410 0.9500645 0.61044 NA NA
CDKN2A neratinib 0.6104631 0.9500645 0.61046 NA NA
BCORL1 olaparib 0.6106976 0.9500645 0.61070 NA NA
TET2 vemurafenib 0.6113322 0.9505542 0.61133 NA NA
VHL ruxolitinib 0.6115548 0.9505542 0.61155 NA NA
WT1 selumetinib 0.6124498 0.9508415 0.61245 NA NA
PDGFB erlotinib 0.6129494 0.9508415 0.61295 NA NA
GATA2 regorafenib 0.6133776 0.9508415 0.61338 NA NA
IL7R vemurafenib 0.6141559 0.9508415 0.61416 NA NA
PHF6 selumetinib 0.6145065 0.9508415 0.61451 NA NA
SSX1 erlotinib 0.6145493 0.9508415 0.61455 NA NA
WT1 afatinib 0.6146663 0.9508415 0.61467 NA NA
PAX8 afatinib 0.6146819 0.9508415 0.61468 NA NA
BCOR azd 0.6149811 0.9508415 0.61498 NA NA
PAX5 nilotinib 0.6150802 0.9508415 0.61508 NA NA
BCORL1 neratinib 0.6156018 0.9508415 0.61560 NA NA
KMT2A selumetinib 0.6156370 0.9508415 0.61564 NA NA
XPO1 belinostat 0.6157812 0.9508415 0.61578 NA NA
ZRSR2 fluorouracil 0.6160040 0.9508415 0.61600 NA NA
PAX5 cyclophosphamide 0.6160580 0.9508415 0.61606 NA NA
PTPN11 crizotinib 0.6160802 0.9508415 0.61608 NA NA
MYD88 ruxolitinib 0.6181728 0.9516061 0.61817 NA NA
ABL1 nilotinib 0.6182260 0.9516061 0.61823 NA NA
CYP19A1 vandetanib 0.6183456 0.9516061 0.61835 NA NA
TSC1 trametinib 0.6186725 0.9516061 0.61867 NA NA
NT5C2 pazopanib 0.6188891 0.9516061 0.61889 NA NA
PIGA temozolomide 0.6192551 0.9516061 0.61926 NA NA
PTPN11 nilotinib 0.6193257 0.9516061 0.61933 NA NA
SF1 selumetinib 0.6193720 0.9516061 0.61937 NA NA
ERBB2 temozolomide 0.6194974 0.9516061 0.61950 NA NA
PDGFRB vemurafenib 0.6197336 0.9516061 0.61973 NA NA
TSC1 olaparib 0.6197994 0.9516061 0.61980 NA NA
PHF6 gefitinib 0.6199449 0.9516061 0.61994 NA NA
STAG2 cabozantinib 0.6204197 0.9516061 0.62042 NA NA
AR temozolomide 0.6204683 0.9516061 0.62047 NA NA
CTNNB1 fluorouracil 0.6209367 0.9516061 0.62094 NA NA
BRCA1 pazopanib 0.6211989 0.9516061 0.62120 NA NA
PDGFRA dabrafenib 0.6212605 0.9516061 0.62126 NA NA
BRCA1 dasatinib 0.6214626 0.9516061 0.62146 NA NA
CDK4 pazopanib 0.6220277 0.9516656 0.62203 NA NA
NPM1 ruxolitinib 0.6223011 0.9516656 0.62230 NA NA
FBXW7 lapatinib 0.6223969 0.9516656 0.62240 NA NA
SMC1A temozolomide 0.6228976 0.9516656 0.62290 NA NA
GNAQ selumetinib 0.6231521 0.9516656 0.62315 NA NA
FBXW7 belinostat 0.6233860 0.9516656 0.62339 NA NA
SH2B3 pazopanib 0.6234996 0.9516656 0.62350 NA NA
FGFR2 selumetinib 0.6236736 0.9516656 0.62367 NA NA
TET2 trametinib 0.6245492 0.9519685 0.62455 NA NA
CDC73 selumetinib 0.6247346 0.9519685 0.62473 NA NA
NT5C2 vandetanib 0.6247551 0.9519685 0.62476 NA NA
CALR erlotinib 0.6249585 0.9519685 0.62496 NA NA
SRSF2 fulvestrant 0.6257755 0.9524460 0.62578 NA NA
TSC2 lapatinib 0.6258155 0.9524460 0.62582 NA NA
SF3B1 belinostat 0.6263425 0.9528345 0.62634 NA NA
CD79B erlotinib 0.6268979 0.9529676 0.62690 NA NA
CYP19A1 ruxolitinib 0.6276320 0.9529676 0.62763 NA NA
AKT2 afatinib 0.6279052 0.9529676 0.62791 NA NA
PIK3CA azd 0.6282066 0.9529676 0.62821 NA NA
SF1 dabrafenib 0.6289304 0.9529676 0.62893 NA NA
IDH1 temozolomide 0.6290971 0.9529676 0.62910 NA NA
ERBB2 ruxolitinib 0.6293981 0.9529676 0.62940 NA NA
ATM imatinib 0.6294816 0.9529676 0.62948 NA NA
PRPF8 pazopanib 0.6300675 0.9529676 0.63007 NA NA
DNMT3A ruxolitinib 0.6300700 0.9529676 0.63007 NA NA
MYCN selumetinib 0.6303901 0.9529676 0.63039 NA NA
ATM erlotinib 0.6305159 0.9529676 0.63052 NA NA
KIT vandetanib 0.6306055 0.9529676 0.63061 NA NA
IDH1 dasatinib 0.6308254 0.9529676 0.63083 NA NA
AKT1 regorafenib 0.6309258 0.9529676 0.63093 NA NA
AKT1 fluorouracil 0.6312805 0.9529676 0.63128 NA NA
RET imatinib 0.6313687 0.9529676 0.63137 NA NA
IKZF1 nilotinib 0.6314605 0.9529676 0.63146 NA NA
FGFR2 cabozantinib 0.6315959 0.9529676 0.63160 NA NA
CBLB vandetanib 0.6330509 0.9544571 0.63305 NA NA
MYCN vemurafenib 0.6331278 0.9544571 0.63313 NA NA
CEBPA afatinib 0.6336638 0.9548545 0.63366 NA NA
SF1 nilotinib 0.6341439 0.9550146 0.63414 NA NA
CDK6 afatinib 0.6345662 0.9550146 0.63457 NA NA
RAD21 afatinib 0.6348632 0.9550146 0.63486 NA NA
CDKN2A dabrafenib 0.6348974 0.9550146 0.63490 NA NA
STAT3 belinostat 0.6351324 0.9550146 0.63513 NA NA
ESR1 azd 0.6359850 0.9554147 0.63598 NA NA
IDH2 crizotinib 0.6363824 0.9554147 0.63638 NA NA
TSC1 erlotinib 0.6364596 0.9554147 0.63646 NA NA
RUNX1 olaparib 0.6364888 0.9554147 0.63649 NA NA
FANCL selumetinib 0.6382296 0.9566868 0.63823 NA NA
MPL fulvestrant 0.6382741 0.9566868 0.63827 NA NA
TP53 erlotinib 0.6385136 0.9566868 0.63851 NA NA
CDC73 neratinib 0.6391371 0.9566868 0.63914 NA NA
STAT3 ruxolitinib 0.6391463 0.9566868 0.63915 NA NA
CBLB ibrutinib 0.6394929 0.9566868 0.63949 NA NA
AKT2 fulvestrant 0.6395519 0.9566868 0.63955 NA NA
STAG2 trametinib 0.6396032 0.9566868 0.63960 NA NA
ERBB3 gefitinib 0.6397928 0.9566868 0.63979 NA NA
CDKN2A belinostat 0.6401072 0.9567487 0.64011 NA NA
EML4 nilotinib 0.6404142 0.9567995 0.64041 NA NA
GNB1 nilotinib 0.6407151 0.9568413 0.64072 NA NA
EED dasatinib 0.6413131 0.9573264 0.64131 NA NA
TSC1 crizotinib 0.6420105 0.9575859 0.64201 NA NA
AKT3 ruxolitinib 0.6421902 0.9575859 0.64219 NA NA
GATA1 nilotinib 0.6426001 0.9575859 0.64260 NA NA
VHL neratinib 0.6428242 0.9575859 0.64282 NA NA
KIT imatinib 0.6429646 0.9575859 0.64296 NA NA
KMT2A azd 0.6439413 0.9575859 0.64394 NA NA
AKT1 pazopanib 0.6440994 0.9575859 0.64410 NA NA
CREBBP imatinib 0.6443870 0.9575859 0.64439 NA NA
PDGFB selumetinib 0.6445370 0.9575859 0.64454 NA NA
CTLA4 pazopanib 0.6447774 0.9575859 0.64478 NA NA
FGFR2 neratinib 0.6455024 0.9575859 0.64550 NA NA
SH2B3 gefitinib 0.6455532 0.9575859 0.64555 NA NA
MET erlotinib 0.6459851 0.9575859 0.64599 NA NA
GNA11 dasatinib 0.6462779 0.9575859 0.64628 NA NA
FGFR1 fulvestrant 0.6465440 0.9575859 0.64654 NA NA
SF1 erlotinib 0.6467566 0.9575859 0.64676 NA NA
HRAS erlotinib 0.6468475 0.9575859 0.64685 NA NA
ERBB4 azd 0.6472118 0.9575859 0.64721 NA NA
FGFR1 dasatinib 0.6473080 0.9575859 0.64731 NA NA
CTCF temozolomide 0.6475611 0.9575859 0.64756 NA NA
ZRSR2 azd 0.6480221 0.9575859 0.64802 NA NA
CD274 imatinib 0.6480891 0.9575859 0.64809 NA NA
EED belinostat 0.6481198 0.9575859 0.64812 NA NA
BRCA1 selumetinib 0.6484298 0.9575859 0.64843 NA NA
MAP2K2 temozolomide 0.6485561 0.9575859 0.64856 NA NA
BTK olaparib 0.6485903 0.9575859 0.64859 NA NA
SETD2 azd 0.6491235 0.9579697 0.64912 NA NA
PRPF8 gefitinib 0.6498661 0.9586619 0.64987 NA NA
ETV6 fulvestrant 0.6504248 0.9590303 0.65042 NA NA
SH2B3 selumetinib 0.6506631 0.9590303 0.65066 NA NA
SRSF2 gefitinib 0.6512892 0.9594723 0.65129 NA NA
PDGFRA afatinib 0.6518163 0.9594723 0.65182 NA NA
ETV6 vemurafenib 0.6520198 0.9594723 0.65202 NA NA
GATA1 imatinib 0.6521039 0.9594723 0.65210 NA NA
JAK3 ruxolitinib 0.6523983 0.9594723 0.65240 NA NA
GNA11 selumetinib 0.6526054 0.9594723 0.65261 NA NA
SH2B3 sunitinib 0.6528930 0.9594926 0.65289 NA NA
ASXL1 imatinib 0.6532854 0.9595107 0.65329 NA NA
FGFR3 vandetanib 0.6537638 0.9595107 0.65376 NA NA
ETV6 dabrafenib 0.6549022 0.9595107 0.65490 NA NA
CBL fulvestrant 0.6549564 0.9595107 0.65496 NA NA
DNMT3A azd 0.6551284 0.9595107 0.65513 NA NA
MYD88 fluorouracil 0.6552215 0.9595107 0.65522 NA NA
IDH2 cyclophosphamide 0.6554963 0.9595107 0.65550 NA NA
ETV6 gefitinib 0.6555992 0.9595107 0.65560 NA NA
TP53 cyclophosphamide 0.6558587 0.9595107 0.65586 NA NA
WHSC1 ibrutinib 0.6566414 0.9595107 0.65664 NA NA
GNAS ruxolitinib 0.6567053 0.9595107 0.65671 NA NA
MYCN olaparib 0.6570819 0.9595107 0.65708 NA NA
U2AF1 ibrutinib 0.6570900 0.9595107 0.65709 NA NA
IL7R dasatinib 0.6571031 0.9595107 0.65710 NA NA
CDK4 erlotinib 0.6574186 0.9595107 0.65742 NA NA
PRPF8 ruxolitinib 0.6575194 0.9595107 0.65752 NA NA
CBL neratinib 0.6577751 0.9595107 0.65778 NA NA
PTPN11 cabozantinib 0.6578329 0.9595107 0.65783 NA NA
BTK cabozantinib 0.6581138 0.9595211 0.65811 NA NA
UGT1A1 neratinib 0.6590084 0.9603542 0.65901 NA NA
CDC73 fluorouracil 0.6592558 0.9603542 0.65926 NA NA
PAX5 neratinib 0.6597538 0.9603542 0.65975 NA NA
WHSC1 olaparib 0.6602208 0.9603542 0.66022 NA NA
BRCA2 ibrutinib 0.6602730 0.9603542 0.66027 NA NA
PTCH1 belinostat 0.6603291 0.9603542 0.66033 NA NA
CTCF olaparib 0.6614206 0.9605459 0.66142 NA NA
RPL10 fluorouracil 0.6614232 0.9605459 0.66142 NA NA
UGT1A1 lapatinib 0.6619661 0.9605459 0.66197 NA NA
TP53 ibrutinib 0.6620836 0.9605459 0.66208 NA NA
TSC1 pazopanib 0.6622597 0.9605459 0.66226 NA NA
GATA3 pazopanib 0.6623315 0.9605459 0.66233 NA NA
FLCN lapatinib 0.6627773 0.9605459 0.66278 NA NA
BRAF regorafenib 0.6631522 0.9605459 0.66315 NA NA
EML4 erlotinib 0.6633749 0.9605459 0.66337 NA NA
KMT2A ibrutinib 0.6634099 0.9605459 0.66341 NA NA
SRSF2 fluorouracil 0.6636437 0.9605459 0.66364 NA NA
ERBB4 selumetinib 0.6645769 0.9605459 0.66458 NA NA
AKT1 dasatinib 0.6650170 0.9605459 0.66502 NA NA
IL7R nilotinib 0.6653695 0.9605459 0.66537 NA NA
ALK belinostat 0.6654501 0.9605459 0.66545 NA NA
G6PD afatinib 0.6656317 0.9605459 0.66563 NA NA
RIT1 fluorouracil 0.6659043 0.9605459 0.66590 NA NA
FANCL cyclophosphamide 0.6659245 0.9605459 0.66592 NA NA
PDGFRA fulvestrant 0.6659409 0.9605459 0.66594 NA NA
PML dabrafenib 0.6659420 0.9605459 0.66594 NA NA
RET nilotinib 0.6667141 0.9609952 0.66671 NA NA
GATA3 selumetinib 0.6669457 0.9609952 0.66695 NA NA
GNA11 erlotinib 0.6670760 0.9609952 0.66708 NA NA
FLCN pazopanib 0.6675138 0.9612308 0.66751 NA NA
PIK3CA selumetinib 0.6680841 0.9613655 0.66808 NA NA
SMC3 fluorouracil 0.6682697 0.9613655 0.66827 NA NA
ASXL1 ibrutinib 0.6684302 0.9613655 0.66843 NA NA
STAG2 lapatinib 0.6687079 0.9613705 0.66871 NA NA
GNA11 temozolomide 0.6695427 0.9615461 0.66954 NA NA
WHSC1 pazopanib 0.6699016 0.9615461 0.66990 NA NA
RUNX1 fluorouracil 0.6701763 0.9615461 0.67018 NA NA
ERBB4 lapatinib 0.6703606 0.9615461 0.67036 NA NA
CDC73 trametinib 0.6705477 0.9615461 0.67055 NA NA
PTPN11 fulvestrant 0.6706631 0.9615461 0.67066 NA NA
SSX1 regorafenib 0.6710825 0.9615461 0.67108 NA NA
SF3B1 imatinib 0.6715539 0.9615461 0.67155 NA NA
BRCA2 lapatinib 0.6720665 0.9615461 0.67207 NA NA
PHF6 ruxolitinib 0.6723384 0.9615461 0.67234 NA NA
MAP2K1 gefitinib 0.6726641 0.9615461 0.67266 NA NA
NPM1 cyclophosphamide 0.6729128 0.9615461 0.67291 NA NA
SETBP1 sunitinib 0.6730323 0.9615461 0.67303 NA NA
FGFR1 belinostat 0.6733402 0.9615461 0.67334 NA NA
SETD2 vemurafenib 0.6735530 0.9615461 0.67355 NA NA
GNA11 olaparib 0.6738118 0.9615461 0.67381 NA NA
G6PD fulvestrant 0.6741823 0.9615461 0.67418 NA NA
PRPF40B erlotinib 0.6742007 0.9615461 0.67420 NA NA
PDGFRB crizotinib 0.6743149 0.9615461 0.67431 NA NA
CTCF sunitinib 0.6748162 0.9615461 0.67482 NA NA
ESR1 fulvestrant 0.6748204 0.9615461 0.67482 NA NA
SETBP1 cyclophosphamide 0.6751023 0.9615461 0.67510 NA NA
BTK nilotinib 0.6754528 0.9615461 0.67545 NA NA
SF1 afatinib 0.6755844 0.9615461 0.67558 NA NA
AR crizotinib 0.6756885 0.9615461 0.67569 NA NA
GNA11 gefitinib 0.6764782 0.9616758 0.67648 NA NA
AKT2 vandetanib 0.6765120 0.9616758 0.67651 NA NA
ATM selumetinib 0.6766027 0.9616758 0.67660 NA NA
KIT olaparib 0.6772410 0.9621604 0.67724 NA NA
ESR1 neratinib 0.6776713 0.9621604 0.67767 NA NA
PTCH1 dabrafenib 0.6781405 0.9621604 0.67814 NA NA
ABL1 azd 0.6783940 0.9621604 0.67839 NA NA
SMC3 imatinib 0.6786729 0.9621604 0.67867 NA NA
MDM2 vandetanib 0.6793257 0.9621604 0.67933 NA NA
PRPF8 neratinib 0.6793499 0.9621604 0.67935 NA NA
ABL1 olaparib 0.6795493 0.9621604 0.67955 NA NA
STAG2 belinostat 0.6797321 0.9621604 0.67973 NA NA
EGFR cabozantinib 0.6800714 0.9621604 0.68007 NA NA
HRAS selumetinib 0.6810792 0.9621604 0.68108 NA NA
PAX5 regorafenib 0.6816533 0.9621604 0.68165 NA NA
MDM2 fulvestrant 0.6817076 0.9621604 0.68171 NA NA
CBL selumetinib 0.6817460 0.9621604 0.68175 NA NA
SF3B1 sunitinib 0.6819577 0.9621604 0.68196 NA NA
RAD21 vandetanib 0.6820722 0.9621604 0.68207 NA NA
ALK ruxolitinib 0.6822022 0.9621604 0.68220 NA NA
UGT1A1 gefitinib 0.6824391 0.9621604 0.68244 NA NA
CD79B nilotinib 0.6828744 0.9621604 0.68287 NA NA
NRAS afatinib 0.6831020 0.9621604 0.68310 NA NA
STAT3 fulvestrant 0.6831760 0.9621604 0.68318 NA NA
ABL1 vandetanib 0.6832739 0.9621604 0.68327 NA NA
NOTCH2 cyclophosphamide 0.6845577 0.9621604 0.68456 NA NA
EED nilotinib 0.6849533 0.9621604 0.68495 NA NA
SETD2 lapatinib 0.6852281 0.9621604 0.68523 NA NA
GATA1 belinostat 0.6853817 0.9621604 0.68538 NA NA
FANCL afatinib 0.6853991 0.9621604 0.68540 NA NA
GNAS afatinib 0.6859032 0.9621604 0.68590 NA NA
FBXW7 ruxolitinib 0.6859258 0.9621604 0.68593 NA NA
JAK3 cabozantinib 0.6866155 0.9621604 0.68662 NA NA
SMC3 crizotinib 0.6867765 0.9621604 0.68678 NA NA
SMC1A azd 0.6870170 0.9621604 0.68702 NA NA
CDC73 dasatinib 0.6870471 0.9621604 0.68705 NA NA
EML4 crizotinib 0.6871346 0.9621604 0.68713 NA NA
TSC1 fulvestrant 0.6874271 0.9621604 0.68743 NA NA
PDCD1 trametinib 0.6874801 0.9621604 0.68748 NA NA
SH2B3 dasatinib 0.6879694 0.9621604 0.68797 NA NA
CREBBP selumetinib 0.6881315 0.9621604 0.68813 NA NA
EGF fulvestrant 0.6882567 0.9621604 0.68826 NA NA
SSX1 afatinib 0.6883730 0.9621604 0.68837 NA NA
CD274 erlotinib 0.6886269 0.9621604 0.68863 NA NA
PTCH1 fluorouracil 0.6889362 0.9621604 0.68894 NA NA
AKT2 nilotinib 0.6891592 0.9621604 0.68916 NA NA
PTCH1 crizotinib 0.6896847 0.9621604 0.68968 NA NA
CEBPA regorafenib 0.6901052 0.9621604 0.69011 NA NA
FGFR1 temozolomide 0.6911917 0.9621604 0.69119 NA NA
GNB1 neratinib 0.6912264 0.9621604 0.69123 NA NA
ERBB2 belinostat 0.6914232 0.9621604 0.69142 NA NA
CYP19A1 afatinib 0.6916918 0.9621604 0.69169 NA NA
JAK1 fluorouracil 0.6918220 0.9621604 0.69182 NA NA
ASXL1 olaparib 0.6918228 0.9621604 0.69182 NA NA
RPL10 gefitinib 0.6920568 0.9621604 0.69206 NA NA
WHSC1 vemurafenib 0.6920627 0.9621604 0.69206 NA NA
BCOR cabozantinib 0.6921730 0.9621604 0.69217 NA NA
ASXL1 erlotinib 0.6922632 0.9621604 0.69226 NA NA
JAK2 olaparib 0.6925765 0.9621604 0.69258 NA NA
SSX1 fulvestrant 0.6927026 0.9621604 0.69270 NA NA
TP53 trametinib 0.6932167 0.9621604 0.69322 NA NA
PIK3CA cyclophosphamide 0.6933966 0.9621604 0.69340 NA NA
ERBB4 nilotinib 0.6934143 0.9621604 0.69341 NA NA
NT5C2 temozolomide 0.6942653 0.9627493 0.69427 NA NA
PML regorafenib 0.6943881 0.9627493 0.69439 NA NA
EML4 cyclophosphamide 0.6949692 0.9630342 0.69497 NA NA
WT1 temozolomide 0.6954830 0.9630342 0.69548 NA NA
MYCN vandetanib 0.6957178 0.9630342 0.69572 NA NA
ERBB3 afatinib 0.6959010 0.9630342 0.69590 NA NA
EGFR fulvestrant 0.6967086 0.9630342 0.69671 NA NA
EML4 sunitinib 0.6967922 0.9630342 0.69679 NA NA
WHSC1 cyclophosphamide 0.6970829 0.9630342 0.69708 NA NA
PTEN dasatinib 0.6975741 0.9630342 0.69757 NA NA
RPL10 olaparib 0.6980888 0.9630342 0.69809 NA NA
PDCD1 fluorouracil 0.6985276 0.9630342 0.69853 NA NA
IDH1 pazopanib 0.6985333 0.9630342 0.69853 NA NA
SSX1 olaparib 0.6986268 0.9630342 0.69863 NA NA
KMT2A pazopanib 0.6990148 0.9630342 0.69901 NA NA
BRCA2 dasatinib 0.6990595 0.9630342 0.69906 NA NA
FGFR1 olaparib 0.6991197 0.9630342 0.69912 NA NA
MDM2 ibrutinib 0.6995678 0.9630342 0.69957 NA NA
AR dabrafenib 0.7000957 0.9630342 0.70010 NA NA
TSC2 fluorouracil 0.7001121 0.9630342 0.70011 NA NA
RPL10 neratinib 0.7004545 0.9630342 0.70045 NA NA
FGFR2 gefitinib 0.7006937 0.9630342 0.70069 NA NA
GNAQ temozolomide 0.7011843 0.9630342 0.70118 NA NA
ZRSR2 imatinib 0.7013451 0.9630342 0.70135 NA NA
NOTCH2 selumetinib 0.7015095 0.9630342 0.70151 NA NA
ZRSR2 pazopanib 0.7015106 0.9630342 0.70151 NA NA
TP53 afatinib 0.7019233 0.9630342 0.70192 NA NA
GATA1 olaparib 0.7020064 0.9630342 0.70201 NA NA
PHF6 olaparib 0.7021468 0.9630342 0.70215 NA NA
IDH1 olaparib 0.7022868 0.9630342 0.70229 NA NA
U2AF1 ruxolitinib 0.7030466 0.9634116 0.70305 NA NA
RPL10 dasatinib 0.7040324 0.9634116 0.70403 NA NA
RUNX1 cyclophosphamide 0.7043026 0.9634116 0.70430 NA NA
U2AF1 dasatinib 0.7043846 0.9634116 0.70438 NA NA
SF1 fulvestrant 0.7044519 0.9634116 0.70445 NA NA
G6PD pazopanib 0.7046983 0.9634116 0.70470 NA NA
GATA1 cyclophosphamide 0.7049215 0.9634116 0.70492 NA NA
IDH1 vemurafenib 0.7055156 0.9634116 0.70552 NA NA
KRAS belinostat 0.7060390 0.9634116 0.70604 NA NA
PAX8 fluorouracil 0.7064565 0.9634116 0.70646 NA NA
EED ruxolitinib 0.7067811 0.9634116 0.70678 NA NA
GATA2 belinostat 0.7068202 0.9634116 0.70682 NA NA
MAP2K1 sunitinib 0.7069036 0.9634116 0.70690 NA NA
PDGFRB azd 0.7069233 0.9634116 0.70692 NA NA
SETD2 olaparib 0.7069566 0.9634116 0.70696 NA NA
BRCA2 imatinib 0.7069599 0.9634116 0.70696 NA NA
BRCA1 vandetanib 0.7073522 0.9635716 0.70735 NA NA
VHL vandetanib 0.7088639 0.9649548 0.70886 NA NA
CBLB crizotinib 0.7089581 0.9649548 0.70896 NA NA
AR cyclophosphamide 0.7092023 0.9649548 0.70920 NA NA
MAP2K2 olaparib 0.7095442 0.9649548 0.70954 NA NA
CDKN2A afatinib 0.7097442 0.9649548 0.70974 NA NA
CRLF2 olaparib 0.7101393 0.9649794 0.71014 NA NA
PTPN11 sunitinib 0.7106955 0.9649794 0.71070 NA NA
NCOA2 olaparib 0.7107660 0.9649794 0.71077 NA NA
UGT1A1 erlotinib 0.7111266 0.9649794 0.71113 NA NA
SRSF2 sunitinib 0.7111389 0.9649794 0.71114 NA NA
MYCN belinostat 0.7115578 0.9650508 0.71156 NA NA
CTNNB1 belinostat 0.7117860 0.9650508 0.71179 NA NA
MAP2K2 crizotinib 0.7120175 0.9650508 0.71202 NA NA
FGFR2 pazopanib 0.7124035 0.9652007 0.71240 NA NA
CEBPA nilotinib 0.7130434 0.9656943 0.71304 NA NA
HRAS fluorouracil 0.7142040 0.9663251 0.71420 NA NA
AR regorafenib 0.7142612 0.9663251 0.71426 NA NA
FGFR3 belinostat 0.7144763 0.9663251 0.71448 NA NA
MDM2 lapatinib 0.7148489 0.9663251 0.71485 NA NA
CEBPA ruxolitinib 0.7148876 0.9663251 0.71489 NA NA
CREBBP pazopanib 0.7158874 0.9667582 0.71589 NA NA
SMC3 ibrutinib 0.7161679 0.9667582 0.71617 NA NA
CBLB imatinib 0.7163256 0.9667582 0.71633 NA NA
NT5C2 ruxolitinib 0.7164474 0.9667582 0.71645 NA NA
FGFR1 azd 0.7172445 0.9667582 0.71724 NA NA
FGFR2 dasatinib 0.7174691 0.9667582 0.71747 NA NA
WHSC1 gefitinib 0.7175619 0.9667582 0.71756 NA NA
NRAS crizotinib 0.7175748 0.9667582 0.71757 NA NA
ASXL1 cyclophosphamide 0.7179652 0.9667582 0.71797 NA NA
GATA2 fulvestrant 0.7180988 0.9667582 0.71810 NA NA
FLT3 gefitinib 0.7182420 0.9667582 0.71824 NA NA
SETBP1 neratinib 0.7187432 0.9670614 0.71874 NA NA
GNAS dasatinib 0.7192252 0.9673385 0.71923 NA NA
EML4 cabozantinib 0.7198333 0.9677003 0.71983 NA NA
PIK3CA belinostat 0.7210139 0.9677003 0.72101 NA NA
CBL ibrutinib 0.7210228 0.9677003 0.72102 NA NA
EGF sunitinib 0.7212933 0.9677003 0.72129 NA NA
BCORL1 pazopanib 0.7216830 0.9677003 0.72168 NA NA
TSC1 belinostat 0.7219457 0.9677003 0.72195 NA NA
BCOR selumetinib 0.7222666 0.9677003 0.72227 NA NA
SETD2 selumetinib 0.7229335 0.9677003 0.72293 NA NA
ETV6 vandetanib 0.7232830 0.9677003 0.72328 NA NA
CSF3R trametinib 0.7240083 0.9677003 0.72401 NA NA
RAD21 trametinib 0.7246309 0.9677003 0.72463 NA NA
STAG2 fluorouracil 0.7248455 0.9677003 0.72485 NA NA
CDK6 fulvestrant 0.7251029 0.9677003 0.72510 NA NA
CD274 selumetinib 0.7251513 0.9677003 0.72515 NA NA
ROS1 vandetanib 0.7251785 0.9677003 0.72518 NA NA
WHSC1 vandetanib 0.7255347 0.9677003 0.72553 NA NA
CD79B olaparib 0.7257215 0.9677003 0.72572 NA NA
FLT3 erlotinib 0.7258031 0.9677003 0.72580 NA NA
GNAS vemurafenib 0.7258712 0.9677003 0.72587 NA NA
PDGFB vandetanib 0.7261157 0.9677003 0.72612 NA NA
PDCD1 selumetinib 0.7265750 0.9677003 0.72658 NA NA
EZH2 erlotinib 0.7269678 0.9677003 0.72697 NA NA
RUNX1 sunitinib 0.7270184 0.9677003 0.72702 NA NA
EZH2 ruxolitinib 0.7272835 0.9677003 0.72728 NA NA
PDCD1 crizotinib 0.7274933 0.9677003 0.72749 NA NA
PRPF8 lapatinib 0.7276562 0.9677003 0.72766 NA NA
MET fluorouracil 0.7280738 0.9677003 0.72807 NA NA
FLT3 trametinib 0.7282232 0.9677003 0.72822 NA NA
CTNNB1 crizotinib 0.7283600 0.9677003 0.72836 NA NA
ROS1 ibrutinib 0.7285250 0.9677003 0.72853 NA NA
FGFR2 azd 0.7287078 0.9677003 0.72871 NA NA
GNAS gefitinib 0.7294199 0.9677003 0.72942 NA NA
SETD2 belinostat 0.7294787 0.9677003 0.72948 NA NA
SH2B3 nilotinib 0.7297621 0.9677003 0.72976 NA NA
PML cyclophosphamide 0.7303617 0.9677003 0.73036 NA NA
SETBP1 crizotinib 0.7305633 0.9677003 0.73056 NA NA
GNB1 vandetanib 0.7307398 0.9677003 0.73074 NA NA
MPL olaparib 0.7309281 0.9677003 0.73093 NA NA
AR fluorouracil 0.7309593 0.9677003 0.73096 NA NA
CRLF2 regorafenib 0.7312969 0.9677003 0.73130 NA NA
TSC1 ruxolitinib 0.7316331 0.9677003 0.73163 NA NA
KMT2A regorafenib 0.7316728 0.9677003 0.73167 NA NA
VHL imatinib 0.7319309 0.9677003 0.73193 NA NA
AKT1 imatinib 0.7320299 0.9677003 0.73203 NA NA
TSC2 gefitinib 0.7322403 0.9677003 0.73224 NA NA
PTCH1 afatinib 0.7324281 0.9677003 0.73243 NA NA
GNAS fulvestrant 0.7326959 0.9677003 0.73270 NA NA
CDK6 vemurafenib 0.7331417 0.9677003 0.73314 NA NA
ERBB3 neratinib 0.7332982 0.9677003 0.73330 NA NA
PDCD1 cabozantinib 0.7339747 0.9677003 0.73397 NA NA
AKT3 dabrafenib 0.7342271 0.9677003 0.73423 NA NA
FLT3 selumetinib 0.7342484 0.9677003 0.73425 NA NA
ERBB3 fluorouracil 0.7345804 0.9677003 0.73458 NA NA
ERBB2 nilotinib 0.7346282 0.9677003 0.73463 NA NA
IDH1 belinostat 0.7346792 0.9677003 0.73468 NA NA
FBXW7 cyclophosphamide 0.7350706 0.9678522 0.73507 NA NA
EGF trametinib 0.7355094 0.9680662 0.73551 NA NA
TSC1 afatinib 0.7361919 0.9681514 0.73619 NA NA
EML4 imatinib 0.7363143 0.9681514 0.73631 NA NA
RAD21 regorafenib 0.7364027 0.9681514 0.73640 NA NA
ASXL1 ruxolitinib 0.7368952 0.9684146 0.73690 NA NA
BTK dabrafenib 0.7372117 0.9684146 0.73721 NA NA
MDM2 neratinib 0.7374318 0.9684146 0.73743 NA NA
STAT3 azd 0.7382568 0.9691349 0.73826 NA NA
ZRSR2 gefitinib 0.7386653 0.9693081 0.73867 NA NA
PDGFB sunitinib 0.7395816 0.9700226 0.73958 NA NA
WT1 pazopanib 0.7397633 0.9700226 0.73976 NA NA
STAT3 lapatinib 0.7404090 0.9700268 0.74041 NA NA
SSX1 vandetanib 0.7404258 0.9700268 0.74043 NA NA
TP53 gefitinib 0.7405968 0.9700268 0.74060 NA NA
GNB1 regorafenib 0.7416132 0.9705976 0.74161 NA NA
CALR sunitinib 0.7418629 0.9705976 0.74186 NA NA
PDGFRA crizotinib 0.7420103 0.9705976 0.74201 NA NA
SRSF2 cyclophosphamide 0.7424401 0.9705976 0.74244 NA NA
UGT1A1 nilotinib 0.7429748 0.9705976 0.74297 NA NA
SETD2 temozolomide 0.7430517 0.9705976 0.74305 NA NA
CDK6 vandetanib 0.7434029 0.9705976 0.74340 NA NA
MGMT selumetinib 0.7434177 0.9705976 0.74342 NA NA
EZH2 afatinib 0.7435342 0.9705976 0.74353 NA NA
PML vandetanib 0.7438018 0.9705976 0.74380 NA NA
RUNX1 neratinib 0.7448410 0.9709248 0.74484 NA NA
EGF fluorouracil 0.7452435 0.9709248 0.74524 NA NA
G6PD olaparib 0.7455081 0.9709248 0.74551 NA NA
IL7R pazopanib 0.7460534 0.9709248 0.74605 NA NA
RAD21 azd 0.7464338 0.9709248 0.74643 NA NA
CD274 ibrutinib 0.7471826 0.9709248 0.74718 NA NA
FANCL erlotinib 0.7475280 0.9709248 0.74753 NA NA
MYCN sunitinib 0.7475925 0.9709248 0.74759 NA NA
IKZF1 afatinib 0.7476410 0.9709248 0.74764 NA NA
BRCA2 gefitinib 0.7477970 0.9709248 0.74780 NA NA
CTLA4 olaparib 0.7480065 0.9709248 0.74801 NA NA
TSC2 imatinib 0.7480994 0.9709248 0.74810 NA NA
JAK2 selumetinib 0.7485902 0.9709248 0.74859 NA NA
EML4 neratinib 0.7486205 0.9709248 0.74862 NA NA
GNAS dabrafenib 0.7487418 0.9709248 0.74874 NA NA
CTNNB1 vandetanib 0.7488945 0.9709248 0.74889 NA NA
KMT2A dabrafenib 0.7496294 0.9709248 0.74963 NA NA
DPYD crizotinib 0.7496551 0.9709248 0.74966 NA NA
PIK3CA vandetanib 0.7497566 0.9709248 0.74976 NA NA
PDCD1 olaparib 0.7498380 0.9709248 0.74984 NA NA
MPL dabrafenib 0.7498697 0.9709248 0.74987 NA NA
GATA1 temozolomide 0.7505399 0.9714337 0.75054 NA NA
MYD88 crizotinib 0.7508273 0.9714469 0.75083 NA NA
RAD21 ibrutinib 0.7522001 0.9726449 0.75220 NA NA
U2AF1 gefitinib 0.7523082 0.9726449 0.75231 NA NA
FGFR3 gefitinib 0.7528586 0.9729975 0.75286 NA NA
PDGFRB dasatinib 0.7535038 0.9734724 0.75350 NA NA
BTK vemurafenib 0.7544061 0.9738676 0.75441 NA NA
PTCH1 gefitinib 0.7546944 0.9738676 0.75469 NA NA
PDGFRB dabrafenib 0.7547325 0.9738676 0.75473 NA NA
IL7R belinostat 0.7551750 0.9738676 0.75518 NA NA
GNA11 pazopanib 0.7551989 0.9738676 0.75520 NA NA
DDIT3 gefitinib 0.7557663 0.9742408 0.75577 NA NA
FGFR3 fluorouracil 0.7561675 0.9743997 0.75617 NA NA
DNAJB1 vandetanib 0.7567350 0.9747726 0.75674 NA NA
XPO1 erlotinib 0.7573883 0.9749020 0.75739 NA NA
CDK6 pazopanib 0.7573918 0.9749020 0.75739 NA NA
CBL imatinib 0.7585602 0.9759807 0.75856 NA NA
NPM1 olaparib 0.7587867 0.9759807 0.75879 NA NA
NOTCH1 erlotinib 0.7601599 0.9769158 0.76016 NA NA
MAP2K1 ruxolitinib 0.7605973 0.9769158 0.76060 NA NA
SMC1A lapatinib 0.7611075 0.9769158 0.76111 NA NA
G6PD temozolomide 0.7612249 0.9769158 0.76122 NA NA
SSX1 fluorouracil 0.7615349 0.9769158 0.76153 NA NA
SETD2 erlotinib 0.7615497 0.9769158 0.76155 NA NA
PDGFRB lapatinib 0.7618885 0.9769158 0.76189 NA NA
FGFR2 erlotinib 0.7624511 0.9769158 0.76245 NA NA
NCOA2 dabrafenib 0.7624986 0.9769158 0.76250 NA NA
PAX5 imatinib 0.7627272 0.9769158 0.76273 NA NA
SETBP1 pazopanib 0.7627633 0.9769158 0.76276 NA NA
ETV6 trametinib 0.7628584 0.9769158 0.76286 NA NA
BTK crizotinib 0.7632016 0.9769984 0.76320 NA NA
BRCA2 regorafenib 0.7635037 0.9770283 0.76350 NA NA
CD79B dasatinib 0.7638200 0.9770763 0.76382 NA NA
SF3B1 dabrafenib 0.7642395 0.9772563 0.76424 NA NA
PAX5 pazopanib 0.7646165 0.9773818 0.76462 NA NA
BCOR dasatinib 0.7654574 0.9781000 0.76546 NA NA
SRSF2 dabrafenib 0.7662650 0.9784357 0.76627 NA NA
DPYD imatinib 0.7666734 0.9784357 0.76667 NA NA
JAK1 fulvestrant 0.7668957 0.9784357 0.76690 NA NA
GATA2 crizotinib 0.7673245 0.9784357 0.76732 NA NA
RAD21 erlotinib 0.7673369 0.9784357 0.76734 NA NA
WT1 olaparib 0.7676886 0.9784357 0.76769 NA NA
TSC2 olaparib 0.7680842 0.9784357 0.76808 NA NA
EGFR sunitinib 0.7681397 0.9784357 0.76814 NA NA
BCOR neratinib 0.7684625 0.9784357 0.76846 NA NA
SH2B3 fluorouracil 0.7685908 0.9784357 0.76859 NA NA
MAP2K1 trametinib 0.7690588 0.9784357 0.76906 NA NA
EZH2 fluorouracil 0.7690864 0.9784357 0.76909 NA NA
DPYD fluorouracil 0.7693491 0.9784357 0.76935 NA NA
RPL10 cyclophosphamide 0.7703411 0.9786997 0.77034 NA NA
IKZF1 fluorouracil 0.7704918 0.9786997 0.77049 NA NA
RPL10 fulvestrant 0.7708354 0.9786997 0.77084 NA NA
IKZF1 pazopanib 0.7712041 0.9786997 0.77120 NA NA
CD79B imatinib 0.7712534 0.9786997 0.77125 NA NA
FLT3 sunitinib 0.7714998 0.9786997 0.77150 NA NA
MYD88 dasatinib 0.7715129 0.9786997 0.77151 NA NA
EGFR fluorouracil 0.7720863 0.9786997 0.77209 NA NA
U2AF1 fulvestrant 0.7724007 0.9786997 0.77240 NA NA
ERBB2 ibrutinib 0.7726805 0.9786997 0.77268 NA NA
PDGFRB vandetanib 0.7728525 0.9786997 0.77285 NA NA
SETBP1 fulvestrant 0.7730012 0.9786997 0.77300 NA NA
SSX1 sunitinib 0.7734115 0.9786997 0.77341 NA NA
TSC2 belinostat 0.7739206 0.9786997 0.77392 NA NA
NOTCH2 pazopanib 0.7741025 0.9786997 0.77410 NA NA
ERBB4 vandetanib 0.7741921 0.9786997 0.77419 NA NA
CDKN2A lapatinib 0.7743037 0.9786997 0.77430 NA NA
AR imatinib 0.7746762 0.9788177 0.77468 NA NA
NOTCH1 dabrafenib 0.7752521 0.9790528 0.77525 NA NA
MDM2 nilotinib 0.7754957 0.9790528 0.77550 NA NA
PDCD1 cyclophosphamide 0.7757004 0.9790528 0.77570 NA NA
SF3B1 dasatinib 0.7765427 0.9790766 0.77654 NA NA
GATA2 gefitinib 0.7766051 0.9790766 0.77661 NA NA
PTPN11 belinostat 0.7770641 0.9790766 0.77706 NA NA
UGT1A1 vemurafenib 0.7774617 0.9790766 0.77746 NA NA
CDK4 neratinib 0.7775511 0.9790766 0.77755 NA NA
MYCN cabozantinib 0.7776618 0.9790766 0.77766 NA NA
ESR1 dasatinib 0.7776986 0.9790766 0.77770 NA NA
PHF6 cyclophosphamide 0.7780757 0.9790766 0.77808 NA NA
CBLB dasatinib 0.7786025 0.9790766 0.77860 NA NA
SMC3 belinostat 0.7787676 0.9790766 0.77877 NA NA
KIT dasatinib 0.7790279 0.9790766 0.77903 NA NA
MYD88 regorafenib 0.7798439 0.9790766 0.77984 NA NA
KMT2A afatinib 0.7799359 0.9790766 0.77994 NA NA
MPL belinostat 0.7800283 0.9790766 0.78003 NA NA
ABL1 dasatinib 0.7801253 0.9790766 0.78013 NA NA
ERBB4 trametinib 0.7804050 0.9790766 0.78040 NA NA
ROS1 dasatinib 0.7804679 0.9790766 0.78047 NA NA
BRCA1 erlotinib 0.7809136 0.9792853 0.78091 NA NA
MYD88 selumetinib 0.7817427 0.9798641 0.78174 NA NA
SETBP1 regorafenib 0.7820389 0.9798641 0.78204 NA NA
RET ibrutinib 0.7824502 0.9798641 0.78245 NA NA
FGFR2 nilotinib 0.7828534 0.9798641 0.78285 NA NA
EGFR belinostat 0.7834615 0.9798641 0.78346 NA NA
ERBB4 dabrafenib 0.7835462 0.9798641 0.78355 NA NA
SMO ibrutinib 0.7840036 0.9798641 0.78400 NA NA
CRLF2 temozolomide 0.7841940 0.9798641 0.78419 NA NA
JAK3 sunitinib 0.7843429 0.9798641 0.78434 NA NA
CYP19A1 neratinib 0.7845031 0.9798641 0.78450 NA NA
SMC1A ruxolitinib 0.7848184 0.9798641 0.78482 NA NA
MET belinostat 0.7848683 0.9798641 0.78487 NA NA
PDGFRB cyclophosphamide 0.7850095 0.9798641 0.78501 NA NA
KMT2A cyclophosphamide 0.7858531 0.9799978 0.78585 NA NA
RPL10 pazopanib 0.7859022 0.9799978 0.78590 NA NA
ASXL1 sunitinib 0.7862155 0.9799978 0.78622 NA NA
PTPN11 regorafenib 0.7868640 0.9799978 0.78686 NA NA
GNB1 crizotinib 0.7868725 0.9799978 0.78687 NA NA
STAT3 fluorouracil 0.7872285 0.9799978 0.78723 NA NA
RAD21 dasatinib 0.7873052 0.9799978 0.78731 NA NA
XPO1 fulvestrant 0.7873535 0.9799978 0.78735 NA NA
MGMT cabozantinib 0.7880782 0.9805517 0.78808 NA NA
MAP2K1 fulvestrant 0.7890076 0.9813166 0.78901 NA NA
RPL10 crizotinib 0.7894759 0.9813166 0.78948 NA NA
PHF6 dabrafenib 0.7898112 0.9813166 0.78981 NA NA
JAK1 crizotinib 0.7899472 0.9813166 0.78995 NA NA
BRCA1 trametinib 0.7902084 0.9813166 0.79021 NA NA
ALK pazopanib 0.7907566 0.9813166 0.79076 NA NA
SMO olaparib 0.7908167 0.9813166 0.79082 NA NA
ERBB4 dasatinib 0.7911289 0.9813166 0.79113 NA NA
NPM1 trametinib 0.7912128 0.9813166 0.79121 NA NA
ETV6 belinostat 0.7917541 0.9813278 0.79175 NA NA
BCOR fluorouracil 0.7920251 0.9813278 0.79203 NA NA
MAP2K1 erlotinib 0.7920617 0.9813278 0.79206 NA NA
NT5C2 olaparib 0.7936469 0.9828251 0.79365 NA NA
WHSC1 nilotinib 0.7941482 0.9828251 0.79415 NA NA
CDKN2A dasatinib 0.7947465 0.9828251 0.79475 NA NA
MYD88 sunitinib 0.7948466 0.9828251 0.79485 NA NA
FLT3 fluorouracil 0.7949588 0.9828251 0.79496 NA NA
EML4 vandetanib 0.7950423 0.9828251 0.79504 NA NA
CTNNB1 selumetinib 0.7952331 0.9828251 0.79523 NA NA
RIT1 azd 0.7955380 0.9828553 0.79554 NA NA
EZH2 fulvestrant 0.7961364 0.9828994 0.79614 NA NA
BRCA2 fulvestrant 0.7961724 0.9828994 0.79617 NA NA
ESR1 vandetanib 0.7965042 0.9828994 0.79650 NA NA
CREBBP vemurafenib 0.7967408 0.9828994 0.79674 NA NA
IDH2 belinostat 0.7972643 0.9828994 0.79726 NA NA
RIT1 belinostat 0.7972643 0.9828994 0.79726 NA NA
ERBB4 imatinib 0.7978043 0.9828994 0.79780 NA NA
GATA1 erlotinib 0.7979982 0.9828994 0.79800 NA NA
CDK6 cyclophosphamide 0.7980975 0.9828994 0.79810 NA NA
CBLB olaparib 0.7988492 0.9834797 0.79885 NA NA
CEBPA belinostat 0.7998303 0.9836788 0.79983 NA NA
NPM1 regorafenib 0.8002281 0.9836788 0.80023 NA NA
GNAQ belinostat 0.8002706 0.9836788 0.80027 NA NA
ROS1 dabrafenib 0.8003190 0.9836788 0.80032 NA NA
NT5C2 cyclophosphamide 0.8013112 0.9836788 0.80131 NA NA
FGFR2 crizotinib 0.8015132 0.9836788 0.80151 NA NA
BCORL1 ruxolitinib 0.8017150 0.9836788 0.80171 NA NA
CDK4 imatinib 0.8018292 0.9836788 0.80183 NA NA
CYP19A1 erlotinib 0.8021724 0.9836788 0.80217 NA NA
EGF lapatinib 0.8021775 0.9836788 0.80218 NA NA
ETV6 olaparib 0.8024774 0.9836788 0.80248 NA NA
PIK3CA ruxolitinib 0.8031527 0.9836788 0.80315 NA NA
JAK3 temozolomide 0.8038280 0.9836788 0.80383 NA NA
TSC2 dabrafenib 0.8039511 0.9836788 0.80395 NA NA
ERBB2 pazopanib 0.8041509 0.9836788 0.80415 NA NA
PIGA olaparib 0.8041925 0.9836788 0.80419 NA NA
EGFR imatinib 0.8043300 0.9836788 0.80433 NA NA
CBLB trametinib 0.8043433 0.9836788 0.80434 NA NA
GATA2 trametinib 0.8043433 0.9836788 0.80434 NA NA
ERBB3 vemurafenib 0.8058873 0.9850988 0.80589 NA NA
GNB1 gefitinib 0.8060666 0.9850988 0.80607 NA NA
IDH2 gefitinib 0.8069304 0.9854890 0.80693 NA NA
AKT1 fulvestrant 0.8069482 0.9854890 0.80695 NA NA
SMC3 fulvestrant 0.8079031 0.9858125 0.80790 NA NA
PAX8 lapatinib 0.8079834 0.9858125 0.80798 NA NA
GATA1 neratinib 0.8080568 0.9858125 0.80806 NA NA
FGFR3 neratinib 0.8083390 0.9858135 0.80834 NA NA
PIGA dabrafenib 0.8089548 0.9858922 0.80895 NA NA
TPMT temozolomide 0.8089661 0.9858922 0.80897 NA NA
VHL gefitinib 0.8099428 0.9867395 0.80994 NA NA
NCOA2 dasatinib 0.8120663 0.9885620 0.81207 NA NA
NPM1 dasatinib 0.8123866 0.9885620 0.81239 NA NA
BRCA1 olaparib 0.8126710 0.9885620 0.81267 NA NA
EED dabrafenib 0.8127835 0.9885620 0.81278 NA NA
FLT3 afatinib 0.8136811 0.9885620 0.81368 NA NA
CTCF cyclophosphamide 0.8140252 0.9885620 0.81403 NA NA
ETV6 afatinib 0.8146140 0.9885620 0.81461 NA NA
MDM2 selumetinib 0.8147845 0.9885620 0.81478 NA NA
IL7R temozolomide 0.8147928 0.9885620 0.81479 NA NA
ETV6 azd 0.8153345 0.9885620 0.81533 NA NA
DDIT3 vandetanib 0.8153829 0.9885620 0.81538 NA NA
BCOR ibrutinib 0.8155517 0.9885620 0.81555 NA NA
MAP2K1 dasatinib 0.8156483 0.9885620 0.81565 NA NA
TSC2 pazopanib 0.8156658 0.9885620 0.81567 NA NA
SMC3 neratinib 0.8156695 0.9885620 0.81567 NA NA
CDC73 lapatinib 0.8163306 0.9887995 0.81633 NA NA
GNB1 temozolomide 0.8165080 0.9887995 0.81651 NA NA
CXCR4 fluorouracil 0.8170913 0.9887995 0.81709 NA NA
PIK3CA afatinib 0.8171902 0.9887995 0.81719 NA NA
EGFR selumetinib 0.8175946 0.9887995 0.81759 NA NA
KRAS fluorouracil 0.8178870 0.9887995 0.81789 NA NA
TET2 dasatinib 0.8180732 0.9887995 0.81807 NA NA
SMC1A dabrafenib 0.8181790 0.9887995 0.81818 NA NA
GNA11 belinostat 0.8191068 0.9887995 0.81911 NA NA
MYCN temozolomide 0.8196022 0.9887995 0.81960 NA NA
DNMT3A dabrafenib 0.8196290 0.9887995 0.81963 NA NA
RAD21 fulvestrant 0.8197611 0.9887995 0.81976 NA NA
KRAS erlotinib 0.8197849 0.9887995 0.81978 NA NA
STAG2 dasatinib 0.8200451 0.9887995 0.82005 NA NA
JAK2 ruxolitinib 0.8206972 0.9887995 0.82070 NA NA
ABL1 neratinib 0.8209775 0.9887995 0.82098 NA NA
CEBPA fluorouracil 0.8210173 0.9887995 0.82102 NA NA
TET2 ibrutinib 0.8210622 0.9887995 0.82106 NA NA
JAK2 pazopanib 0.8212255 0.9887995 0.82123 NA NA
GNAQ azd 0.8215610 0.9888638 0.82156 NA NA
ESR1 afatinib 0.8221452 0.9892272 0.82215 NA NA
WT1 regorafenib 0.8227347 0.9895969 0.82273 NA NA
AKT2 cabozantinib 0.8236951 0.9900197 0.82370 NA NA
AKT2 ruxolitinib 0.8237974 0.9900197 0.82380 NA NA
SH2B3 erlotinib 0.8239336 0.9900197 0.82393 NA NA
AKT1 selumetinib 0.8255265 0.9901690 0.82553 NA NA
ERBB3 dasatinib 0.8265066 0.9901690 0.82651 NA NA
ERBB3 regorafenib 0.8265906 0.9901690 0.82659 NA NA
SF3B1 crizotinib 0.8266905 0.9901690 0.82669 NA NA
G6PD belinostat 0.8270727 0.9901690 0.82707 NA NA
ASXL1 azd 0.8276807 0.9901690 0.82768 NA NA
WHSC1 azd 0.8277442 0.9901690 0.82774 NA NA
BCORL1 fulvestrant 0.8280004 0.9901690 0.82800 NA NA
BRCA2 sunitinib 0.8280670 0.9901690 0.82807 NA NA
WT1 ruxolitinib 0.8282677 0.9901690 0.82827 NA NA
CDC73 pazopanib 0.8285791 0.9901690 0.82858 NA NA
CDC73 dabrafenib 0.8289484 0.9901690 0.82895 NA NA
RUNX1 fulvestrant 0.8302092 0.9901690 0.83021 NA NA
CXCR4 cyclophosphamide 0.8303971 0.9901690 0.83040 NA NA
PDCD1 temozolomide 0.8304264 0.9901690 0.83043 NA NA
SSX1 trametinib 0.8304781 0.9901690 0.83048 NA NA
EML4 ruxolitinib 0.8305349 0.9901690 0.83053 NA NA
TSC2 regorafenib 0.8307456 0.9901690 0.83075 NA NA
TET2 imatinib 0.8307873 0.9901690 0.83079 NA NA
CXCR4 olaparib 0.8315103 0.9901690 0.83151 NA NA
XPO1 imatinib 0.8319911 0.9901690 0.83199 NA NA
STAG2 fulvestrant 0.8322921 0.9901690 0.83229 NA NA
AR olaparib 0.8323296 0.9901690 0.83233 NA NA
JAK3 trametinib 0.8326907 0.9901690 0.83269 NA NA
ABL1 dabrafenib 0.8331314 0.9901690 0.83313 NA NA
SRSF2 selumetinib 0.8333064 0.9901690 0.83331 NA NA
GNA11 dabrafenib 0.8333252 0.9901690 0.83333 NA NA
CD79B azd 0.8339485 0.9901690 0.83395 NA NA
CDKN2A temozolomide 0.8345836 0.9901690 0.83458 NA NA
WT1 trametinib 0.8346931 0.9901690 0.83469 NA NA
JAK2 imatinib 0.8347277 0.9901690 0.83473 NA NA
CDK6 dasatinib 0.8347746 0.9901690 0.83477 NA NA
GNAQ trametinib 0.8351033 0.9901690 0.83510 NA NA
RPL10 afatinib 0.8354031 0.9901690 0.83540 NA NA
GATA3 nilotinib 0.8356779 0.9901690 0.83568 NA NA
ABL1 pazopanib 0.8358559 0.9901690 0.83586 NA NA
FANCL lapatinib 0.8358929 0.9901690 0.83589 NA NA
CDKN2A fulvestrant 0.8364018 0.9901690 0.83640 NA NA
IL7R sunitinib 0.8364552 0.9901690 0.83646 NA NA
MPL ibrutinib 0.8367132 0.9901690 0.83671 NA NA
ERBB4 ruxolitinib 0.8371657 0.9901690 0.83717 NA NA
GATA2 cyclophosphamide 0.8372522 0.9901690 0.83725 NA NA
GATA2 vandetanib 0.8374238 0.9901690 0.83742 NA NA
SETD2 gefitinib 0.8377146 0.9901690 0.83771 NA NA
TPMT nilotinib 0.8378567 0.9901690 0.83786 NA NA
ATM gefitinib 0.8382793 0.9901690 0.83828 NA NA
JAK3 fluorouracil 0.8384838 0.9901690 0.83848 NA NA
BRCA2 ruxolitinib 0.8386749 0.9901690 0.83867 NA NA
CXCR4 regorafenib 0.8387356 0.9901690 0.83874 NA NA
CALR fulvestrant 0.8400737 0.9901690 0.84007 NA NA
MYCN fulvestrant 0.8400737 0.9901690 0.84007 NA NA
TPMT fulvestrant 0.8400737 0.9901690 0.84007 NA NA
CBLB pazopanib 0.8405158 0.9901690 0.84052 NA NA
WHSC1 dasatinib 0.8407025 0.9901690 0.84070 NA NA
FLCN dabrafenib 0.8408160 0.9901690 0.84082 NA NA
EML4 regorafenib 0.8409376 0.9901690 0.84094 NA NA
GNAQ pazopanib 0.8416682 0.9901690 0.84167 NA NA
FBXW7 crizotinib 0.8421141 0.9901690 0.84211 NA NA
MPL neratinib 0.8432221 0.9901690 0.84322 NA NA
KIT belinostat 0.8435673 0.9901690 0.84357 NA NA
ABL1 sunitinib 0.8440587 0.9901690 0.84406 NA NA
EGFR cyclophosphamide 0.8442118 0.9901690 0.84421 NA NA
TPMT belinostat 0.8445547 0.9901690 0.84455 NA NA
SSX1 nilotinib 0.8447109 0.9901690 0.84471 NA NA
PDGFRB erlotinib 0.8448409 0.9901690 0.84484 NA NA
PML azd 0.8448624 0.9901690 0.84486 NA NA
CSF3R fulvestrant 0.8452868 0.9901690 0.84529 NA NA
GNB1 fulvestrant 0.8452868 0.9901690 0.84529 NA NA
PDGFB fulvestrant 0.8455325 0.9901690 0.84553 NA NA
ATM trametinib 0.8460191 0.9901690 0.84602 NA NA
DNMT3A belinostat 0.8463546 0.9901690 0.84635 NA NA
SSX1 dabrafenib 0.8464862 0.9901690 0.84649 NA NA
NT5C2 trametinib 0.8473892 0.9901690 0.84739 NA NA
ALK cabozantinib 0.8474970 0.9901690 0.84750 NA NA
PIGA afatinib 0.8479000 0.9901690 0.84790 NA NA
SETBP1 ruxolitinib 0.8481381 0.9901690 0.84814 NA NA
JAK2 belinostat 0.8481782 0.9901690 0.84818 NA NA
AKT2 cyclophosphamide 0.8485860 0.9901690 0.84859 NA NA
ETV6 pazopanib 0.8487861 0.9901690 0.84879 NA NA
ESR1 ruxolitinib 0.8489985 0.9901690 0.84900 NA NA
MGMT pazopanib 0.8490601 0.9901690 0.84906 NA NA
BCORL1 afatinib 0.8491104 0.9901690 0.84911 NA NA
MDM2 crizotinib 0.8495487 0.9901690 0.84955 NA NA
WT1 crizotinib 0.8499747 0.9901690 0.84997 NA NA
PDGFB afatinib 0.8499921 0.9901690 0.84999 NA NA
AR fulvestrant 0.8505013 0.9901690 0.85050 NA NA
BRCA1 ibrutinib 0.8510774 0.9901690 0.85108 NA NA
SSX1 pazopanib 0.8510912 0.9901690 0.85109 NA NA
CDC73 belinostat 0.8513755 0.9901690 0.85138 NA NA
IDH2 nilotinib 0.8513822 0.9901690 0.85138 NA NA
FBXW7 nilotinib 0.8513899 0.9901690 0.85139 NA NA
ERBB4 fulvestrant 0.8515382 0.9901690 0.85154 NA NA
SH2B3 olaparib 0.8520608 0.9901690 0.85206 NA NA
VHL erlotinib 0.8523932 0.9901690 0.85239 NA NA
CYP19A1 pazopanib 0.8533966 0.9901690 0.85340 NA NA
NCOA2 belinostat 0.8534104 0.9901690 0.85341 NA NA
BTK fluorouracil 0.8538624 0.9901690 0.85386 NA NA
BCORL1 regorafenib 0.8541459 0.9901690 0.85415 NA NA
IKZF1 ruxolitinib 0.8543153 0.9901690 0.85432 NA NA
EZH2 regorafenib 0.8544445 0.9901690 0.85444 NA NA
EML4 pazopanib 0.8549461 0.9901690 0.85495 NA NA
PDGFRA imatinib 0.8550665 0.9901690 0.85507 NA NA
CDK4 cyclophosphamide 0.8551752 0.9901690 0.85518 NA NA
XPO1 vandetanib 0.8552812 0.9901690 0.85528 NA NA
BCORL1 gefitinib 0.8556379 0.9901690 0.85564 NA NA
PDGFB crizotinib 0.8558808 0.9901690 0.85588 NA NA
SF1 trametinib 0.8561422 0.9901690 0.85614 NA NA
PTCH1 neratinib 0.8565156 0.9901690 0.85652 NA NA
FLCN azd 0.8570215 0.9901690 0.85702 NA NA
CD79B crizotinib 0.8579080 0.9901690 0.85791 NA NA
CDK4 olaparib 0.8579502 0.9901690 0.85795 NA NA
G6PD neratinib 0.8580742 0.9901690 0.85807 NA NA
EED cabozantinib 0.8584187 0.9901690 0.85842 NA NA
GNA11 regorafenib 0.8586729 0.9901690 0.85867 NA NA
ATM fluorouracil 0.8591468 0.9901690 0.85915 NA NA
CDK6 neratinib 0.8593447 0.9901690 0.85934 NA NA
GNB1 olaparib 0.8596219 0.9901690 0.85962 NA NA
WT1 dasatinib 0.8598469 0.9901690 0.85985 NA NA
IL7R cyclophosphamide 0.8604368 0.9901690 0.86044 NA NA
CRLF2 nilotinib 0.8605840 0.9901690 0.86058 NA NA
GNA11 vandetanib 0.8607348 0.9901690 0.86073 NA NA
ERBB3 temozolomide 0.8609254 0.9901690 0.86093 NA NA
ASXL1 dabrafenib 0.8609421 0.9901690 0.86094 NA NA
ZRSR2 afatinib 0.8610270 0.9901690 0.86103 NA NA
PAX8 selumetinib 0.8611213 0.9901690 0.86112 NA NA
CDK4 nilotinib 0.8612838 0.9901690 0.86128 NA NA
FLT3 neratinib 0.8622113 0.9901690 0.86221 NA NA
ETV6 neratinib 0.8623161 0.9901690 0.86232 NA NA
ERBB3 trametinib 0.8637892 0.9901690 0.86379 NA NA
ROS1 selumetinib 0.8640047 0.9901690 0.86400 NA NA
PAX5 crizotinib 0.8641086 0.9901690 0.86411 NA NA
CDK4 ibrutinib 0.8648076 0.9901690 0.86481 NA NA
MET ruxolitinib 0.8650705 0.9901690 0.86507 NA NA
SETBP1 ibrutinib 0.8651240 0.9901690 0.86512 NA NA
MYCN imatinib 0.8657933 0.9901690 0.86579 NA NA
BTK selumetinib 0.8659890 0.9901690 0.86599 NA NA
CEBPA olaparib 0.8664644 0.9901690 0.86646 NA NA
TSC2 selumetinib 0.8665087 0.9901690 0.86651 NA NA
FGFR2 olaparib 0.8666403 0.9901690 0.86664 NA NA
PTPN11 pazopanib 0.8671743 0.9901690 0.86717 NA NA
AKT2 sunitinib 0.8673466 0.9901690 0.86735 NA NA
RAD21 lapatinib 0.8675443 0.9901690 0.86754 NA NA
PRPF40B azd 0.8675461 0.9901690 0.86755 NA NA
RIT1 erlotinib 0.8681157 0.9901690 0.86812 NA NA
CDC73 azd 0.8684061 0.9901690 0.86841 NA NA
DDIT3 afatinib 0.8686331 0.9901690 0.86863 NA NA
CEBPA pazopanib 0.8688202 0.9901690 0.86882 NA NA
RPL10 sunitinib 0.8688961 0.9901690 0.86890 NA NA
CDK6 erlotinib 0.8703063 0.9901690 0.87031 NA NA
ETV6 imatinib 0.8709192 0.9901690 0.87092 NA NA
GNAQ vemurafenib 0.8709776 0.9901690 0.87098 NA NA
EML4 lapatinib 0.8710187 0.9901690 0.87102 NA NA
BRCA1 cyclophosphamide 0.8713387 0.9901690 0.87134 NA NA
ALK cyclophosphamide 0.8716671 0.9901690 0.87167 NA NA
MAP2K2 cabozantinib 0.8719884 0.9901690 0.87199 NA NA
WT1 cabozantinib 0.8720627 0.9901690 0.87206 NA NA
CTNNB1 dabrafenib 0.8720644 0.9901690 0.87206 NA NA
PDCD1 erlotinib 0.8721579 0.9901690 0.87216 NA NA
ERBB2 regorafenib 0.8725903 0.9901690 0.87259 NA NA
CD79B lapatinib 0.8728609 0.9901690 0.87286 NA NA
CTCF belinostat 0.8730931 0.9901690 0.87309 NA NA
CALR crizotinib 0.8731382 0.9901690 0.87314 NA NA
IKZF1 azd 0.8732022 0.9901690 0.87320 NA NA
AR ibrutinib 0.8734298 0.9901690 0.87343 NA NA
EGFR temozolomide 0.8736252 0.9901690 0.87363 NA NA
ZRSR2 neratinib 0.8736410 0.9901690 0.87364 NA NA
ZRSR2 sunitinib 0.8739101 0.9901690 0.87391 NA NA
PML ibrutinib 0.8740839 0.9901690 0.87408 NA NA
STAG2 erlotinib 0.8742188 0.9901690 0.87422 NA NA
CBL fluorouracil 0.8743145 0.9901690 0.87431 NA NA
IKZF1 belinostat 0.8743214 0.9901690 0.87432 NA NA
RAD21 neratinib 0.8743887 0.9901690 0.87439 NA NA
KMT2A ruxolitinib 0.8745846 0.9901690 0.87458 NA NA
PAX5 dasatinib 0.8746189 0.9901690 0.87462 NA NA
NOTCH1 ibrutinib 0.8747156 0.9901690 0.87472 NA NA
DDIT3 imatinib 0.8751828 0.9901690 0.87518 NA NA
SF1 pazopanib 0.8761149 0.9901690 0.87611 NA NA
PHF6 regorafenib 0.8764457 0.9901690 0.87645 NA NA
IKZF1 fulvestrant 0.8765449 0.9901690 0.87654 NA NA
NRAS azd 0.8767650 0.9901690 0.87677 NA NA
IL7R cabozantinib 0.8768350 0.9901690 0.87683 NA NA
NOTCH1 afatinib 0.8771401 0.9901690 0.87714 NA NA
MET ibrutinib 0.8773082 0.9901690 0.87731 NA NA
EML4 afatinib 0.8779886 0.9901690 0.87799 NA NA
RAD21 olaparib 0.8780532 0.9901690 0.87805 NA NA
FGFR3 dasatinib 0.8781896 0.9901690 0.87819 NA NA
G6PD erlotinib 0.8787499 0.9901690 0.87875 NA NA
GNAS fluorouracil 0.8790478 0.9901690 0.87905 NA NA
EED sunitinib 0.8795398 0.9901690 0.87954 NA NA
CEBPA erlotinib 0.8795684 0.9901690 0.87957 NA NA
PDGFB cabozantinib 0.8796954 0.9901690 0.87970 NA NA
TET2 ruxolitinib 0.8800224 0.9901690 0.88002 NA NA
SETBP1 fluorouracil 0.8804096 0.9901690 0.88041 NA NA
WT1 gefitinib 0.8804501 0.9901690 0.88045 NA NA
CREBBP azd 0.8805935 0.9901690 0.88059 NA NA
SH2B3 ruxolitinib 0.8811335 0.9901690 0.88113 NA NA
BRCA1 ruxolitinib 0.8813093 0.9901690 0.88131 NA NA
GNAS trametinib 0.8817413 0.9901690 0.88174 NA NA
BTK gefitinib 0.8818601 0.9901690 0.88186 NA NA
ERBB3 olaparib 0.8819557 0.9901690 0.88196 NA NA
NPM1 vemurafenib 0.8824014 0.9901690 0.88240 NA NA
ESR1 pazopanib 0.8825243 0.9901690 0.88252 NA NA
ABL1 vemurafenib 0.8828642 0.9901690 0.88286 NA NA
JAK3 afatinib 0.8828760 0.9901690 0.88288 NA NA
BCORL1 temozolomide 0.8832119 0.9901690 0.88321 NA NA
NCOA2 erlotinib 0.8832155 0.9901690 0.88322 NA NA
PIK3CA neratinib 0.8835236 0.9901690 0.88352 NA NA
KIT vemurafenib 0.8838594 0.9901690 0.88386 NA NA
CXCR4 gefitinib 0.8843316 0.9901690 0.88433 NA NA
BRAF crizotinib 0.8847422 0.9901690 0.88474 NA NA
SRSF2 nilotinib 0.8848890 0.9901690 0.88489 NA NA
BCOR belinostat 0.8851071 0.9901690 0.88511 NA NA
MGMT regorafenib 0.8856536 0.9901690 0.88565 NA NA
CSF3R ruxolitinib 0.8856788 0.9901690 0.88568 NA NA
JAK1 azd 0.8862899 0.9901690 0.88629 NA NA
FLT3 azd 0.8863568 0.9901690 0.88636 NA NA
ZRSR2 erlotinib 0.8863915 0.9901690 0.88639 NA NA
DDIT3 ruxolitinib 0.8865939 0.9901690 0.88659 NA NA
TSC2 fulvestrant 0.8866945 0.9901690 0.88669 NA NA
MDM2 vemurafenib 0.8868806 0.9901690 0.88688 NA NA
RET temozolomide 0.8870447 0.9901690 0.88704 NA NA
CEBPA dasatinib 0.8870621 0.9901690 0.88706 NA NA
EGFR gefitinib 0.8875800 0.9901690 0.88758 NA NA
SSX1 imatinib 0.8883152 0.9901690 0.88832 NA NA
JAK1 afatinib 0.8886426 0.9901690 0.88864 NA NA
MYCN ruxolitinib 0.8887309 0.9901690 0.88873 NA NA
FANCL fluorouracil 0.8887309 0.9901690 0.88873 NA NA
MET dasatinib 0.8890135 0.9901690 0.88901 NA NA
AKT3 pazopanib 0.8894602 0.9901690 0.88946 NA NA
IKZF1 gefitinib 0.8895230 0.9901690 0.88952 NA NA
MAP2K1 crizotinib 0.8899455 0.9901690 0.88995 NA NA
BTK ibrutinib 0.8905387 0.9901690 0.89054 NA NA
FGFR3 fulvestrant 0.8912589 0.9901690 0.89126 NA NA
PML neratinib 0.8916365 0.9901690 0.89164 NA NA
SF3B1 cabozantinib 0.8924725 0.9901690 0.89247 NA NA
PDCD1 fulvestrant 0.8929813 0.9901690 0.89298 NA NA
ABL1 erlotinib 0.8935609 0.9901690 0.89356 NA NA
KMT2A belinostat 0.8939542 0.9901690 0.89395 NA NA
AKT3 vandetanib 0.8940163 0.9901690 0.89402 NA NA
KIT nilotinib 0.8943017 0.9901690 0.89430 NA NA
MGMT ibrutinib 0.8947146 0.9901690 0.89471 NA NA
JAK2 lapatinib 0.8953005 0.9901690 0.89530 NA NA
FANCL dasatinib 0.8954609 0.9901690 0.89546 NA NA
MET imatinib 0.8955374 0.9901690 0.89554 NA NA
PRPF40B temozolomide 0.8962251 0.9901690 0.89623 NA NA
PAX5 temozolomide 0.8962677 0.9901690 0.89627 NA NA
ERBB2 lapatinib 0.8966122 0.9901690 0.89661 NA NA
BRCA2 fluorouracil 0.8966696 0.9901690 0.89667 NA NA
CD274 trametinib 0.8969249 0.9901690 0.89692 NA NA
CALR fluorouracil 0.8969467 0.9901690 0.89695 NA NA
MYD88 belinostat 0.8969609 0.9901690 0.89696 NA NA
VHL afatinib 0.8971402 0.9901690 0.89714 NA NA
CTNNB1 ruxolitinib 0.8971632 0.9901690 0.89716 NA NA
CDK4 gefitinib 0.8973876 0.9901690 0.89739 NA NA
GNB1 azd 0.8976665 0.9901690 0.89767 NA NA
SETD2 afatinib 0.8979054 0.9901690 0.89791 NA NA
EZH2 imatinib 0.8979601 0.9901690 0.89796 NA NA
EZH2 neratinib 0.8979687 0.9901690 0.89797 NA NA
NOTCH1 neratinib 0.8979859 0.9901690 0.89799 NA NA
DDIT3 fluorouracil 0.8980325 0.9901690 0.89803 NA NA
SMO cabozantinib 0.8988218 0.9901690 0.89882 NA NA
CXCR4 imatinib 0.8988463 0.9901690 0.89885 NA NA
SMO lapatinib 0.8990292 0.9901690 0.89903 NA NA
GATA1 vandetanib 0.8993971 0.9901690 0.89940 NA NA
PRPF8 imatinib 0.8995458 0.9901690 0.89955 NA NA
CYP19A1 crizotinib 0.8996262 0.9901690 0.89963 NA NA
GATA1 ibrutinib 0.8996914 0.9901690 0.89969 NA NA
IDH2 sunitinib 0.9001651 0.9901690 0.90017 NA NA
CEBPA fulvestrant 0.9003949 0.9901690 0.90039 NA NA
FLT3 cyclophosphamide 0.9009165 0.9901690 0.90092 NA NA
TP53 imatinib 0.9010883 0.9901690 0.90109 NA NA
NPM1 belinostat 0.9011013 0.9901690 0.90110 NA NA
ERBB4 neratinib 0.9011809 0.9901690 0.90118 NA NA
NOTCH1 gefitinib 0.9031224 0.9919912 0.90312 NA NA
IDH2 temozolomide 0.9035358 0.9921344 0.90354 NA NA
IDH1 gefitinib 0.9049664 0.9928310 0.90497 NA NA
SF3B1 fluorouracil 0.9050933 0.9928310 0.90509 NA NA
JAK3 selumetinib 0.9055879 0.9928310 0.90559 NA NA
SETD2 trametinib 0.9058139 0.9928310 0.90581 NA NA
RPL10 ruxolitinib 0.9059576 0.9928310 0.90596 NA NA
JAK3 azd 0.9060871 0.9928310 0.90609 NA NA
WHSC1 neratinib 0.9064544 0.9928310 0.90645 NA NA
TPMT vemurafenib 0.9065616 0.9928310 0.90656 NA NA
SH2B3 crizotinib 0.9067196 0.9928310 0.90672 NA NA
ESR1 crizotinib 0.9085657 0.9931862 0.90857 NA NA
JAK2 dasatinib 0.9093889 0.9931862 0.90939 NA NA
ESR1 cyclophosphamide 0.9094059 0.9931862 0.90941 NA NA
FGFR3 ruxolitinib 0.9104004 0.9931862 0.91040 NA NA
EZH2 dasatinib 0.9104821 0.9931862 0.91048 NA NA
NRAS dasatinib 0.9112650 0.9931862 0.91127 NA NA
RET olaparib 0.9112727 0.9931862 0.91127 NA NA
ATM sunitinib 0.9116286 0.9931862 0.91163 NA NA
ETV6 lapatinib 0.9116653 0.9931862 0.91167 NA NA
DNMT3A fulvestrant 0.9118771 0.9931862 0.91188 NA NA
FGFR2 ibrutinib 0.9119707 0.9931862 0.91197 NA NA
PTCH1 vandetanib 0.9121958 0.9931862 0.91220 NA NA
JAK2 fluorouracil 0.9122887 0.9931862 0.91229 NA NA
SF3B1 afatinib 0.9126648 0.9931862 0.91266 NA NA
CTCF ruxolitinib 0.9127056 0.9931862 0.91271 NA NA
PRPF40B trametinib 0.9130833 0.9931862 0.91308 NA NA
CALR neratinib 0.9131151 0.9931862 0.91312 NA NA
MAP2K2 ruxolitinib 0.9139936 0.9931862 0.91399 NA NA
PTCH1 ruxolitinib 0.9145576 0.9931862 0.91456 NA NA
FGFR1 imatinib 0.9147300 0.9931862 0.91473 NA NA
MPL lapatinib 0.9148092 0.9931862 0.91481 NA NA
PDGFB lapatinib 0.9150133 0.9931862 0.91501 NA NA
GATA2 erlotinib 0.9150198 0.9931862 0.91502 NA NA
PAX8 dasatinib 0.9151131 0.9931862 0.91511 NA NA
SF3B1 regorafenib 0.9151696 0.9931862 0.91517 NA NA
ASXL1 dasatinib 0.9152073 0.9931862 0.91521 NA NA
PDCD1 afatinib 0.9153046 0.9931862 0.91530 NA NA
PIK3CA fulvestrant 0.9164663 0.9931862 0.91647 NA NA
CDK4 belinostat 0.9164906 0.9931862 0.91649 NA NA
AKT1 dabrafenib 0.9165171 0.9931862 0.91652 NA NA
DPYD pazopanib 0.9171346 0.9931862 0.91713 NA NA
AKT3 sunitinib 0.9176482 0.9931862 0.91765 NA NA
ROS1 fluorouracil 0.9179969 0.9931862 0.91800 NA NA
FBXW7 sunitinib 0.9181264 0.9931862 0.91813 NA NA
PRPF8 fulvestrant 0.9181909 0.9931862 0.91819 NA NA
ERBB4 ibrutinib 0.9182459 0.9931862 0.91825 NA NA
STAT3 olaparib 0.9184964 0.9931862 0.91850 NA NA
PDGFRA olaparib 0.9187781 0.9931862 0.91878 NA NA
GNAS azd 0.9189541 0.9931862 0.91895 NA NA
EGFR neratinib 0.9192244 0.9931862 0.91922 NA NA
DDIT3 vemurafenib 0.9192306 0.9931862 0.91923 NA NA
IKZF1 regorafenib 0.9194406 0.9931862 0.91944 NA NA
PTCH1 cyclophosphamide 0.9194906 0.9931862 0.91949 NA NA
CDK6 crizotinib 0.9196852 0.9931862 0.91969 NA NA
IL7R gefitinib 0.9203635 0.9931862 0.92036 NA NA
GNB1 pazopanib 0.9205719 0.9931862 0.92057 NA NA
TSC2 ibrutinib 0.9206937 0.9931862 0.92069 NA NA
NT5C2 crizotinib 0.9211815 0.9931862 0.92118 NA NA
PDGFB cyclophosphamide 0.9213531 0.9931862 0.92135 NA NA
SETBP1 imatinib 0.9215378 0.9931862 0.92154 NA NA
ESR1 selumetinib 0.9216779 0.9931862 0.92168 NA NA
MYD88 cyclophosphamide 0.9220687 0.9931862 0.92207 NA NA
CYP19A1 trametinib 0.9221480 0.9931862 0.92215 NA NA
UGT1A1 belinostat 0.9223455 0.9931862 0.92235 NA NA
JAK2 neratinib 0.9230054 0.9932228 0.92301 NA NA
SSX1 ibrutinib 0.9231222 0.9932228 0.92312 NA NA
BCOR cyclophosphamide 0.9232296 0.9932228 0.92323 NA NA
PDCD1 neratinib 0.9236462 0.9933661 0.92365 NA NA
ESR1 belinostat 0.9247735 0.9935595 0.92477 NA NA
SF1 vandetanib 0.9253818 0.9935595 0.92538 NA NA
STAG2 gefitinib 0.9254803 0.9935595 0.92548 NA NA
EZH2 cyclophosphamide 0.9256457 0.9935595 0.92565 NA NA
PDGFRA belinostat 0.9258624 0.9935595 0.92586 NA NA
EGFR pazopanib 0.9261994 0.9935595 0.92620 NA NA
DDIT3 olaparib 0.9263339 0.9935595 0.92633 NA NA
MAP2K1 selumetinib 0.9267489 0.9935595 0.92675 NA NA
BRCA2 nilotinib 0.9267694 0.9935595 0.92677 NA NA
UGT1A1 vandetanib 0.9276534 0.9935595 0.92765 NA NA
PRPF8 sunitinib 0.9277772 0.9935595 0.92778 NA NA
BTK pazopanib 0.9281695 0.9935595 0.92817 NA NA
CXCR4 trametinib 0.9282956 0.9935595 0.92830 NA NA
GATA3 belinostat 0.9283758 0.9935595 0.92838 NA NA
IDH1 ruxolitinib 0.9283856 0.9935595 0.92839 NA NA
MDM2 imatinib 0.9286632 0.9935595 0.92866 NA NA
PIGA neratinib 0.9287545 0.9935595 0.92875 NA NA
PTEN vemurafenib 0.9289285 0.9935595 0.92893 NA NA
JAK1 pazopanib 0.9297271 0.9937771 0.92973 NA NA
GATA2 afatinib 0.9301179 0.9937771 0.93012 NA NA
AR lapatinib 0.9302671 0.9937771 0.93027 NA NA
FLT3 vandetanib 0.9305740 0.9937771 0.93057 NA NA
CTLA4 dasatinib 0.9318118 0.9937771 0.93181 NA NA
CREBBP lapatinib 0.9318908 0.9937771 0.93189 NA NA
EGF cyclophosphamide 0.9323090 0.9937771 0.93231 NA NA
NCOA2 temozolomide 0.9323112 0.9937771 0.93231 NA NA
XPO1 pazopanib 0.9324116 0.9937771 0.93241 NA NA
NOTCH2 belinostat 0.9326123 0.9937771 0.93261 NA NA
CBL vandetanib 0.9326788 0.9937771 0.93268 NA NA
CEBPA gefitinib 0.9327284 0.9937771 0.93273 NA NA
AKT1 belinostat 0.9332615 0.9937771 0.93326 NA NA
SMC1A belinostat 0.9334362 0.9937771 0.93344 NA NA
SH2B3 neratinib 0.9336448 0.9937771 0.93364 NA NA
AKT2 ibrutinib 0.9339351 0.9937771 0.93394 NA NA
PRPF8 olaparib 0.9339520 0.9937771 0.93395 NA NA
BRCA1 afatinib 0.9350732 0.9938801 0.93507 NA NA
ERBB3 ibrutinib 0.9351931 0.9938801 0.93519 NA NA
RIT1 sunitinib 0.9358763 0.9938801 0.93588 NA NA
CBL temozolomide 0.9359277 0.9938801 0.93593 NA NA
SMC1A pazopanib 0.9360098 0.9938801 0.93601 NA NA
IDH2 ibrutinib 0.9361769 0.9938801 0.93618 NA NA
CD79B afatinib 0.9362534 0.9938801 0.93625 NA NA
EGFR crizotinib 0.9363173 0.9938801 0.93632 NA NA
FGFR3 cyclophosphamide 0.9369354 0.9939304 0.93694 NA NA
AKT2 pazopanib 0.9370564 0.9939304 0.93706 NA NA
NOTCH2 crizotinib 0.9372154 0.9939304 0.93722 NA NA
SMC3 ruxolitinib 0.9375989 0.9940363 0.93760 NA NA
IDH2 fluorouracil 0.9380996 0.9942665 0.93810 NA NA
SSX1 vemurafenib 0.9396473 0.9952513 0.93965 NA NA
STAG2 crizotinib 0.9397555 0.9952513 0.93976 NA NA
CDK6 ruxolitinib 0.9401740 0.9952513 0.94017 NA NA
CTLA4 crizotinib 0.9407221 0.9952513 0.94072 NA NA
CBLB belinostat 0.9407517 0.9952513 0.94075 NA NA
MYD88 olaparib 0.9407553 0.9952513 0.94076 NA NA
NOTCH1 cyclophosphamide 0.9414847 0.9952513 0.94148 NA NA
ERBB2 sunitinib 0.9415781 0.9952513 0.94158 NA NA
BCORL1 fluorouracil 0.9415844 0.9952513 0.94158 NA NA
FLT3 ruxolitinib 0.9427873 0.9959329 0.94279 NA NA
AKT3 neratinib 0.9427975 0.9959329 0.94280 NA NA
GNAS crizotinib 0.9437095 0.9962945 0.94371 NA NA
FGFR3 azd 0.9439579 0.9962945 0.94396 NA NA
CBLB gefitinib 0.9443486 0.9962945 0.94435 NA NA
IKZF1 dabrafenib 0.9445109 0.9962945 0.94451 NA NA
IDH2 regorafenib 0.9449361 0.9962945 0.94494 NA NA
EED trametinib 0.9451365 0.9962945 0.94514 NA NA
BCOR crizotinib 0.9453853 0.9962945 0.94539 NA NA
SRSF2 azd 0.9457703 0.9962945 0.94577 NA NA
SSX1 azd 0.9457703 0.9962945 0.94577 NA NA
U2AF1 imatinib 0.9459823 0.9962945 0.94598 NA NA
FGFR1 cabozantinib 0.9465185 0.9965597 0.94652 NA NA
SF3B1 lapatinib 0.9473691 0.9966036 0.94737 NA NA
KMT2A olaparib 0.9477038 0.9966036 0.94770 NA NA
ASXL1 afatinib 0.9477215 0.9966036 0.94772 NA NA
GATA3 regorafenib 0.9477853 0.9966036 0.94779 NA NA
CTLA4 selumetinib 0.9479818 0.9966036 0.94798 NA NA
CBLB afatinib 0.9482971 0.9966360 0.94830 NA NA
MAP2K2 lapatinib 0.9490923 0.9970065 0.94909 NA NA
CYP19A1 gefitinib 0.9492185 0.9970065 0.94922 NA NA
ROS1 neratinib 0.9510033 0.9974133 0.95100 NA NA
GATA1 trametinib 0.9511799 0.9974133 0.95118 NA NA
CDC73 crizotinib 0.9512685 0.9974133 0.95127 NA NA
RUNX1 belinostat 0.9516637 0.9974133 0.95166 NA NA
MYCN gefitinib 0.9527789 0.9974133 0.95278 NA NA
FLCN neratinib 0.9536094 0.9974133 0.95361 NA NA
GNB1 lapatinib 0.9537834 0.9974133 0.95378 NA NA
SETD2 vandetanib 0.9539574 0.9974133 0.95396 NA NA
EML4 belinostat 0.9539855 0.9974133 0.95399 NA NA
PRPF40B belinostat 0.9540890 0.9974133 0.95409 NA NA
NPM1 imatinib 0.9542718 0.9974133 0.95427 NA NA
EZH2 trametinib 0.9543379 0.9974133 0.95434 NA NA
FBXW7 regorafenib 0.9544165 0.9974133 0.95442 NA NA
PHF6 lapatinib 0.9545753 0.9974133 0.95458 NA NA
RUNX1 vandetanib 0.9545957 0.9974133 0.95460 NA NA
NOTCH2 ruxolitinib 0.9549655 0.9974133 0.95497 NA NA
CSF3R erlotinib 0.9552814 0.9974133 0.95528 NA NA
EML4 fluorouracil 0.9557093 0.9974133 0.95571 NA NA
KIT fluorouracil 0.9561079 0.9974133 0.95611 NA NA
CXCR4 erlotinib 0.9561802 0.9974133 0.95618 NA NA
G6PD ruxolitinib 0.9561889 0.9974133 0.95619 NA NA
PDGFRB olaparib 0.9563573 0.9974133 0.95636 NA NA
ABL1 lapatinib 0.9564785 0.9974133 0.95648 NA NA
STAG2 imatinib 0.9565871 0.9974133 0.95659 NA NA
ALK sunitinib 0.9567200 0.9974133 0.95672 NA NA
BTK lapatinib 0.9573567 0.9974624 0.95736 NA NA
EML4 olaparib 0.9575189 0.9974624 0.95752 NA NA
XPO1 lapatinib 0.9580799 0.9974624 0.95808 NA NA
PRPF8 trametinib 0.9590313 0.9974624 0.95903 NA NA
CBLB fluorouracil 0.9594755 0.9974624 0.95948 NA NA
CTCF ibrutinib 0.9594929 0.9974624 0.95949 NA NA
CD274 gefitinib 0.9597297 0.9974624 0.95973 NA NA
CRLF2 fulvestrant 0.9598588 0.9974624 0.95986 NA NA
SRSF2 pazopanib 0.9606497 0.9974624 0.96065 NA NA
EGF belinostat 0.9616768 0.9974624 0.96168 NA NA
BCOR lapatinib 0.9618340 0.9974624 0.96183 NA NA
PDGFB temozolomide 0.9628530 0.9974624 0.96285 NA NA
IL7R fluorouracil 0.9644846 0.9974624 0.96448 NA NA
MYD88 erlotinib 0.9646182 0.9974624 0.96462 NA NA
DDIT3 nilotinib 0.9647471 0.9974624 0.96475 NA NA
PDCD1 regorafenib 0.9648149 0.9974624 0.96481 NA NA
PTCH1 ibrutinib 0.9649617 0.9974624 0.96496 NA NA
IL7R imatinib 0.9651681 0.9974624 0.96517 NA NA
EZH2 pazopanib 0.9654333 0.9974624 0.96543 NA NA
TSC1 cyclophosphamide 0.9655074 0.9974624 0.96551 NA NA
EML4 vemurafenib 0.9655257 0.9974624 0.96553 NA NA
ESR1 dabrafenib 0.9659108 0.9974624 0.96591 NA NA
GATA1 ruxolitinib 0.9659289 0.9974624 0.96593 NA NA
DNMT3A regorafenib 0.9661684 0.9974624 0.96617 NA NA
FLCN ruxolitinib 0.9662498 0.9974624 0.96625 NA NA
EZH2 vemurafenib 0.9665676 0.9974624 0.96657 NA NA
BRCA1 dabrafenib 0.9666621 0.9974624 0.96666 NA NA
KIT fulvestrant 0.9667212 0.9974624 0.96672 NA NA
PHF6 trametinib 0.9667334 0.9974624 0.96673 NA NA
XPO1 crizotinib 0.9667804 0.9974624 0.96678 NA NA
EED azd 0.9667815 0.9974624 0.96678 NA NA
NCOA2 selumetinib 0.9669234 0.9974624 0.96692 NA NA
ERBB2 olaparib 0.9669476 0.9974624 0.96695 NA NA
CALR belinostat 0.9669583 0.9974624 0.96696 NA NA
AKT1 nilotinib 0.9672155 0.9974624 0.96722 NA NA
FGFR2 afatinib 0.9675251 0.9974624 0.96753 NA NA
EML4 dasatinib 0.9678093 0.9974624 0.96781 NA NA
MYCN regorafenib 0.9684122 0.9974624 0.96841 NA NA
ROS1 imatinib 0.9684583 0.9974624 0.96846 NA NA
ERBB2 crizotinib 0.9689644 0.9974624 0.96896 NA NA
IKZF1 selumetinib 0.9704495 0.9974624 0.97045 NA NA
CBL belinostat 0.9706806 0.9974624 0.97068 NA NA
TSC1 gefitinib 0.9708568 0.9974624 0.97086 NA NA
SF1 cyclophosphamide 0.9717760 0.9974624 0.97178 NA NA
SRSF2 imatinib 0.9719927 0.9974624 0.97199 NA NA
DDIT3 regorafenib 0.9725031 0.9974624 0.97250 NA NA
PRPF8 ibrutinib 0.9726461 0.9974624 0.97265 NA NA
CBL ruxolitinib 0.9727074 0.9974624 0.97271 NA NA
DPYD olaparib 0.9728161 0.9974624 0.97282 NA NA
DPYD ibrutinib 0.9736731 0.9974624 0.97367 NA NA
CEBPA vemurafenib 0.9737661 0.9974624 0.97377 NA NA
GNB1 imatinib 0.9748158 0.9974624 0.97482 NA NA
CREBBP cabozantinib 0.9751680 0.9974624 0.97517 NA NA
XPO1 cyclophosphamide 0.9753028 0.9974624 0.97530 NA NA
BTK sunitinib 0.9753496 0.9974624 0.97535 NA NA
G6PD crizotinib 0.9756109 0.9974624 0.97561 NA NA
MDM2 fluorouracil 0.9760470 0.9974624 0.97605 NA NA
AR nilotinib 0.9764453 0.9974624 0.97645 NA NA
DDIT3 crizotinib 0.9765232 0.9974624 0.97652 NA NA
UGT1A1 fulvestrant 0.9765345 0.9974624 0.97653 NA NA
STAG2 cyclophosphamide 0.9766301 0.9974624 0.97663 NA NA
MDM2 belinostat 0.9766324 0.9974624 0.97663 NA NA
FGFR3 sunitinib 0.9772450 0.9974624 0.97724 NA NA
IKZF1 cabozantinib 0.9773678 0.9974624 0.97737 NA NA
EZH2 temozolomide 0.9773752 0.9974624 0.97738 NA NA
MDM2 azd 0.9774556 0.9974624 0.97746 NA NA
CBL vemurafenib 0.9774758 0.9974624 0.97748 NA NA
SMC3 pazopanib 0.9774832 0.9974624 0.97748 NA NA
ATM crizotinib 0.9777348 0.9974624 0.97773 NA NA
PAX5 lapatinib 0.9778607 0.9974624 0.97786 NA NA
FGFR2 vemurafenib 0.9778868 0.9974624 0.97789 NA NA
DPYD dasatinib 0.9779403 0.9974624 0.97794 NA NA
SMC1A sunitinib 0.9782705 0.9974624 0.97827 NA NA
CBLB azd 0.9783756 0.9974624 0.97838 NA NA
IDH1 vandetanib 0.9787934 0.9974624 0.97879 NA NA
G6PD imatinib 0.9790505 0.9974624 0.97905 NA NA
PDGFRA cyclophosphamide 0.9793614 0.9974624 0.97936 NA NA
CTCF pazopanib 0.9794886 0.9974624 0.97949 NA NA
MAP2K1 afatinib 0.9795938 0.9974624 0.97959 NA NA
SF3B1 cyclophosphamide 0.9798172 0.9974624 0.97982 NA NA
IKZF1 sunitinib 0.9798183 0.9974624 0.97982 NA NA
JAK1 ruxolitinib 0.9810934 0.9984704 0.98109 NA NA
HRAS gefitinib 0.9823491 0.9994583 0.98235 NA NA
ERBB3 erlotinib 0.9832344 0.9998174 0.98323 NA NA
WT1 imatinib 0.9832727 0.9998174 0.98327 NA NA
PAX5 trametinib 0.9843143 1.0000000 0.98431 NA NA
PAX8 olaparib 0.9845620 1.0000000 0.98456 NA NA
CBL afatinib 0.9852397 1.0000000 0.98524 NA NA
PRPF40B crizotinib 0.9855953 1.0000000 0.98560 NA NA
MDM2 dabrafenib 0.9857206 1.0000000 0.98572 NA NA
XPO1 selumetinib 0.9858655 1.0000000 0.98587 NA NA
JAK3 belinostat 0.9859752 1.0000000 0.98598 NA NA
U2AF1 crizotinib 0.9865012 1.0000000 0.98650 NA NA
PAX8 neratinib 0.9866863 1.0000000 0.98669 NA NA
BRAF gefitinib 0.9871832 1.0000000 0.98718 NA NA
FGFR3 cabozantinib 0.9879399 1.0000000 0.98794 NA NA
CDK6 ibrutinib 0.9879518 1.0000000 0.98795 NA NA
CTCF lapatinib 0.9879662 1.0000000 0.98797 NA NA
CBLB ruxolitinib 0.9884828 1.0000000 0.98848 NA NA
BRCA1 crizotinib 0.9886434 1.0000000 0.98864 NA NA
CD274 neratinib 0.9887228 1.0000000 0.98872 NA NA
KIT temozolomide 0.9895199 1.0000000 0.98952 NA NA
RET dabrafenib 0.9896121 1.0000000 0.98961 NA NA
FLT3 crizotinib 0.9896386 1.0000000 0.98964 NA NA
BRAF sunitinib 0.9897961 1.0000000 0.98980 NA NA
WT1 sunitinib 0.9898986 1.0000000 0.98990 NA NA
STAG2 temozolomide 0.9902967 1.0000000 0.99030 NA NA
STAG2 vemurafenib 0.9904545 1.0000000 0.99045 NA NA
ETV6 regorafenib 0.9912002 1.0000000 0.99120 NA NA
DDIT3 selumetinib 0.9916042 1.0000000 0.99160 NA NA
CSF3R sunitinib 0.9917743 1.0000000 0.99177 NA NA
SMO sunitinib 0.9917820 1.0000000 0.99178 NA NA
EGF crizotinib 0.9920321 1.0000000 0.99203 NA NA
STAT3 dabrafenib 0.9920667 1.0000000 0.99207 NA NA
RUNX1 afatinib 0.9923135 1.0000000 0.99231 NA NA
PRPF8 azd 0.9929652 1.0000000 0.99297 NA NA
NCOA2 fluorouracil 0.9943555 1.0000000 0.99436 NA NA
CDK4 fluorouracil 0.9946043 1.0000000 0.99460 NA NA
CDC73 cyclophosphamide 0.9950218 1.0000000 0.99502 NA NA
AR vandetanib 0.9953796 1.0000000 0.99538 NA NA
NPM1 afatinib 0.9954026 1.0000000 0.99540 NA NA
VHL dasatinib 0.9955844 1.0000000 0.99558 NA NA
MAP2K2 neratinib 0.9959548 1.0000000 0.99595 NA NA
ETV6 dasatinib 0.9960355 1.0000000 0.99604 NA NA
GATA3 imatinib 0.9964441 1.0000000 0.99644 NA NA
MYCN dabrafenib 0.9968376 1.0000000 0.99684 NA NA
NT5C2 belinostat 0.9968944 1.0000000 0.99689 NA NA
AKT3 cyclophosphamide 0.9970280 1.0000000 0.99703 NA NA
KMT2A trametinib 0.9973656 1.0000000 0.99737 NA NA
PTEN cyclophosphamide 0.9974631 1.0000000 0.99746 NA NA
KIT ruxolitinib 0.9977843 1.0000000 0.99778 NA NA
UGT1A1 dasatinib 0.9980158 1.0000000 0.99802 NA NA
GNA11 fluorouracil 0.9983479 1.0000000 0.99835 NA NA
IKZF1 ibrutinib 0.9985223 1.0000000 0.99852 NA NA
NT5C2 dasatinib 0.9985337 1.0000000 0.99853 NA NA
AKT3 cabozantinib 0.9986095 1.0000000 0.99861 NA NA
EZH2 vandetanib 0.9991178 1.0000000 0.99912 NA NA
EED selumetinib 0.9992472 1.0000000 0.99925 NA NA
AR dasatinib 0.9996814 1.0000000 0.99968 NA NA
FANCL vandetanib 1.0000000 1.0000000 1.00000 NA NA
FANCL ibrutinib 1.0000000 1.0000000 1.00000 NA NA
SF3B1 neratinib 1.0000000 1.0000000 1.00000 NA NA
SRSF2 dasatinib 1.0000000 1.0000000 1.00000 NA NA 
ctrp_signif_lvlA_ByDrug <- readRDS("./data_munging/rds/ctrp_signif_lvlA_ByDrug.rds")
ctrp_signif_lvlA_ByDrug_all <- rbindlist(ctrp_signif_lvlA_ByDrug, use.names = TRUE)
ctrp_signif_lvlA_ByDrug_all <- ctrp_signif_lvlA_ByDrug_all[order(ctrp_signif_lvlA_ByDrug_all$p.adj),]

knitr::kable(ctrp_signif_lvlA_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: by-drug Wilcoxon test results for Level A point mutations, (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CTRP: by-drug Wilcoxon test results for Level A point mutations, (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
KRAS trametinib 0.0000000 0.0000011 8.5e-09 **** ****
BRAF trametinib 0.0001576 0.0102447 0.00016 ***
BRAF dabrafenib 0.0001234 0.0161618 0.00012 ***
CDKN2A trametinib 0.0003927 0.0170174 0.00039 ***
PTEN belinostat 0.0002105 0.0275704 0.00021 ***
BCORL1 temozolomide 0.0003147 0.0412289 0.00031 ***
TP53 docetaxel 0.0004703 0.0436874 0.00047 ***
CDKN2A docetaxel 0.0006721 0.0436874 0.00067 ***
PDGFRB cabozantinib 0.0005036 0.0659694 0.0005 *** NA
PIK3CA docetaxel 0.0023604 0.1022847 0.00236 ** NA
EZH2 bosutinib monohydrate 0.0011913 0.1548657 0.0012 ** NA
PDGFRB tretinoin 0.0032063 0.2164264 0.0032 ** NA
XPO1 tretinoin 0.0033296 0.2164264 0.0033 ** NA
KRAS palbociclib 0.0017081 0.2237674 0.0017 ** NA
NCOA2 temozolomide 0.0057459 0.2308994 0.00575 ** NA
GNAS temozolomide 0.0072122 0.2308994 0.00721 ** NA
TSC1 temozolomide 0.0073262 0.2308994 0.00733 ** NA
WHSC1 temozolomide 0.0104370 0.2308994 0.01044
NA
ETV6 temozolomide 0.0105755 0.2308994 0.01058
NA
ROS1 cabozantinib 0.0037056 0.2427151 0.0037 ** NA
NRAS trametinib 0.0075575 0.2456199 0.00756 ** NA
JAK1 temozolomide 0.0139643 0.2613316 0.01396
NA
VHL gefitinib 0.0020451 0.2658686 0.0020 ** NA
DNMT3A temozolomide 0.0163008 0.2669262 0.01630
NA
CTNNB1 temozolomide 0.0219771 0.2727138 0.02198
NA
CTCF temozolomide 0.0242740 0.2727138 0.02427
NA
VHL temozolomide 0.0253591 0.2727138 0.02536
NA
AR temozolomide 0.0274000 0.2727138 0.02740
NA
GNAQ temozolomide 0.0282137 0.2727138 0.02821
NA
CALR temozolomide 0.0292063 0.2727138 0.02921
NA
IKZF1 temozolomide 0.0321740 0.2727138 0.03217
NA
IL7R temozolomide 0.0343195 0.2727138 0.03432
NA
XPO1 temozolomide 0.0353903 0.2727138 0.03539
NA
ERBB3 temozolomide 0.0387034 0.2732555 0.03870
NA
NOTCH2 temozolomide 0.0404672 0.2732555 0.04047
NA
EZH2 temozolomide 0.0417184 0.2732555 0.04172
NA
PDCD1 temozolomide 0.0440126 0.2745547 0.04401
NA
SSX1 temozolomide 0.0487651 0.2865197 0.04877
NA
TPMT temozolomide 0.0503050 0.2865197 0.05030 NA NA
SETBP1 temozolomide 0.0526678 0.2874785 0.05267 NA NA
CDKN2A palbociclib 0.0077157 0.2961566 0.0077 ** NA
ALK palbociclib 0.0089754 0.2961566 0.0090 ** NA
SETBP1 palbociclib 0.0102198 0.2961566 0.0102
NA
CREBBP palbociclib 0.0129659 0.2961566 0.0130
NA
TP53 palbociclib 0.0135644 0.2961566 0.0136
NA
TET2 temozolomide 0.0678581 0.3414027 0.06786 NA NA
FGFR3 temozolomide 0.0685390 0.3414027 0.06854 NA NA
STAG2 temozolomide 0.0703654 0.3414027 0.07037 NA NA
SMO temozolomide 0.0771994 0.3611829 0.07720 NA NA
EGF gefitinib 0.0056307 0.3615114 0.0056 ** NA
NOTCH1 gefitinib 0.0083426 0.3615114 0.0083 ** NA
NOTCH2 gefitinib 0.0154450 0.3649982 0.0154
NA
FGFR3 gefitinib 0.0163800 0.3649982 0.0164
NA
TP53 gefitinib 0.0171497 0.3649982 0.0171
NA
ABL1 gefitinib 0.0196537 0.3649982 0.0197
NA
SMC3 tretinoin 0.0138983 0.3692445 0.0139
NA
NOTCH2 tretinoin 0.0152457 0.3692445 0.0152
NA
ZRSR2 tretinoin 0.0162776 0.3692445 0.0163
NA
BRCA1 tretinoin 0.0170421 0.3692445 0.0170
NA
MAP2K1 tretinoin 0.0288016 0.3746647 0.0288
NA
GNAQ tretinoin 0.0312954 0.3746647 0.0313
NA
AR tretinoin 0.0321095 0.3746647 0.0321
NA
EZH2 tretinoin 0.0330076 0.3746647 0.0330
NA
NPM1 tretinoin 0.0355459 0.3746647 0.0355
NA
FANCL tretinoin 0.0383049 0.3746647 0.0383
NA
TSC1 tretinoin 0.0414817 0.3746647 0.0415
NA
CDC73 tretinoin 0.0420071 0.3746647 0.0420
NA
GNAS tretinoin 0.0432305 0.3746647 0.0432
NA
CD274 temozolomide 0.0837166 0.3781679 0.08372 NA NA
CD79B temozolomide 0.0884961 0.3806075 0.08850 NA NA
PRPF40B temozolomide 0.0965946 0.3806075 0.09659 NA NA
NOTCH1 temozolomide 0.0980228 0.3806075 0.09802 NA NA
SMC3 temozolomide 0.0984456 0.3806075 0.09845 NA NA
MAP2K1 temozolomide 0.0987836 0.3806075 0.09878 NA NA
ATM tretinoin 0.0517302 0.4031994 0.0517 NA NA
SF3B1 tretinoin 0.0527261 0.4031994 0.0527 NA NA
CALR dabrafenib 0.0081373 0.4055764 0.00814 ** NA
NOTCH2 dabrafenib 0.0122810 0.4055764 0.01228
NA
XPO1 dabrafenib 0.0123840 0.4055764 0.01238
NA
TPMT cabozantinib 0.0218657 0.4056922 0.0219
NA
SH2B3 cabozantinib 0.0231792 0.4056922 0.0232
NA
DNAJB1 cabozantinib 0.0250495 0.4056922 0.0250
NA
FLT3 cabozantinib 0.0283979 0.4056922 0.0284
NA
TET2 cabozantinib 0.0296182 0.4056922 0.0296
NA
MAP2K2 cabozantinib 0.0302155 0.4056922 0.0302
NA
KMT2A cabozantinib 0.0319699 0.4056922 0.0320
NA
ZRSR2 cabozantinib 0.0342010 0.4056922 0.0342
NA
PHF6 cabozantinib 0.0380544 0.4056922 0.0381
NA
SETBP1 cabozantinib 0.0422020 0.4056922 0.0422
NA
ABL1 cabozantinib 0.0433477 0.4056922 0.0433
NA
CTNNB1 cabozantinib 0.0433564 0.4056922 0.0434
NA
ROS1 trametinib 0.0160528 0.4082794 0.01605
NA
CDK6 trametinib 0.0198135 0.4082794 0.01981
NA
SF3B1 trametinib 0.0228964 0.4082794 0.02290
NA
UGT1A1 trametinib 0.0274916 0.4082794 0.02749
NA
GATA2 trametinib 0.0282655 0.4082794 0.02827
NA
AKT2 temozolomide 0.1148997 0.4201641 0.11490 NA NA
ESR1 temozolomide 0.1154649 0.4201641 0.11546 NA NA
DNAJB1 trametinib 0.0348374 0.4296196 0.03484
NA
NOTCH1 trametinib 0.0408364 0.4296196 0.04084
NA
AKT3 trametinib 0.0423852 0.4296196 0.04239
NA
IDH1 trametinib 0.0480714 0.4296196 0.04807
NA
ZRSR2 trametinib 0.0485098 0.4296196 0.04851
NA
CALR trametinib 0.0553623 0.4296196 0.05536 NA NA
JAK3 trametinib 0.0579978 0.4296196 0.05800 NA NA
TP53 trametinib 0.0601194 0.4296196 0.06012 NA NA
ETV6 trametinib 0.0619050 0.4296196 0.06190 NA NA
PDCD1 trametinib 0.0627906 0.4296196 0.06279 NA NA
EZH2 cabozantinib 0.0549646 0.4358681 0.0550 NA NA
PTEN cabozantinib 0.0616827 0.4358681 0.0617 NA NA
WHSC1 cabozantinib 0.0636458 0.4358681 0.0636 NA NA
PTCH1 cabozantinib 0.0650780 0.4358681 0.0651 NA NA
NRAS cabozantinib 0.0660514 0.4358681 0.0661 NA NA
EML4 cabozantinib 0.0665447 0.4358681 0.0665 NA NA
RAD21 cabozantinib 0.0702610 0.4382946 0.0703 NA NA
PIK3CA cabozantinib 0.0738778 0.4399086 0.0739 NA NA
NOTCH1 afatinib 0.0065209 0.4471019 0.0065 ** NA
VHL afatinib 0.0079992 0.4471019 0.0080 ** NA
EGF afatinib 0.0156979 0.4471019 0.0157
NA
PIK3CA afatinib 0.0170969 0.4471019 0.0171
NA
ERBB2 afatinib 0.0171962 0.4471019 0.0172
NA
STAT3 tretinoin 0.0621330 0.4487384 0.0621 NA NA
ERBB2 temozolomide 0.1311049 0.4521498 0.13110 NA NA
IDH2 temozolomide 0.1311580 0.4521498 0.13116 NA NA
SMC3 cabozantinib 0.0794697 0.4526318 0.0795 NA NA
RPL10 cabozantinib 0.0850440 0.4532310 0.0850 NA NA
FBXW7 cabozantinib 0.0914621 0.4532310 0.0915 NA NA
CTLA4 cabozantinib 0.0933469 0.4532310 0.0933 NA NA
IDH2 cabozantinib 0.0934140 0.4532310 0.0934 NA NA
JAK1 cabozantinib 0.0992758 0.4536172 0.0993 NA NA
JAK2 cabozantinib 0.1004191 0.4536172 0.1004 NA NA
EED temozolomide 0.1353524 0.4536628 0.13535 NA NA
GNB1 temozolomide 0.1386197 0.4536628 0.13862 NA NA
CDC73 temozolomide 0.1419861 0.4536628 0.14199 NA NA
IL7R tretinoin 0.0766084 0.4599481 0.0766 NA NA
CSF3R tretinoin 0.0822956 0.4599481 0.0823 NA NA
SMO tretinoin 0.0848756 0.4599481 0.0849 NA NA
RPL10 tretinoin 0.0862479 0.4599481 0.0862 NA NA
UGT1A1 tretinoin 0.0911112 0.4599481 0.0911 NA NA
BRCA2 tretinoin 0.0916313 0.4599481 0.0916 NA NA
TPMT tretinoin 0.0957413 0.4599481 0.0957 NA NA
CTLA4 tretinoin 0.0990569 0.4599481 0.0991 NA NA
MYCN tretinoin 0.1019536 0.4599481 0.1020 NA NA
ETV6 tretinoin 0.1021380 0.4599481 0.1021 NA NA
PTEN tretinoin 0.1038671 0.4599481 0.1039 NA NA
TSC2 tretinoin 0.1061419 0.4599481 0.1061 NA NA
RUNX1 tretinoin 0.1125899 0.4616724 0.1126 NA NA
ROS1 tretinoin 0.1136424 0.4616724 0.1136 NA NA
GNB1 ruxolitinib 0.0035419 0.4639873 0.0035 ** NA
NRAS imatinib 0.0040262 0.4670344 0.004 ** NA
KIT trametinib 0.0733706 0.4671724 0.07337 NA NA
CDC73 trametinib 0.0754663 0.4671724 0.07547 NA NA
CD274 cabozantinib 0.1100504 0.4673779 0.1101 NA NA
FGFR2 cabozantinib 0.1132666 0.4673779 0.1133 NA NA
MDM2 cabozantinib 0.1141686 0.4673779 0.1142 NA NA
PDGFRA tretinoin 0.1216752 0.4705311 0.1217 NA NA
KIT tretinoin 0.1249785 0.4705311 0.1250 NA NA
NCOA2 tretinoin 0.1266814 0.4705311 0.1267 NA NA
PRPF8 temozolomide 0.1540934 0.4806246 0.15409 NA NA
PAX5 cabozantinib 0.1242237 0.4822894 0.1242 NA NA
TP53 cabozantinib 0.1336110 0.4822894 0.1336 NA NA
PTPN11 cabozantinib 0.1354785 0.4822894 0.1355 NA NA
PDGFRA cabozantinib 0.1407290 0.4822894 0.1407 NA NA
KIT cabozantinib 0.1434514 0.4822894 0.1435 NA NA
KRAS cabozantinib 0.1437272 0.4822894 0.1437 NA NA
BCOR cabozantinib 0.1489401 0.4822894 0.1489 NA NA
CRLF2 cabozantinib 0.1490076 0.4822894 0.1490 NA NA
ERBB4 cabozantinib 0.1509455 0.4822894 0.1509 NA NA
TSC2 temozolomide 0.1628876 0.4916012 0.16289 NA NA
RUNX1 temozolomide 0.1651179 0.4916012 0.16512 NA NA
JAK2 trametinib 0.0900127 0.4967736 0.09001 NA NA
SETBP1 trametinib 0.0962877 0.4967736 0.09629 NA NA
FGFR2 trametinib 0.0984897 0.4967736 0.09849 NA NA
WT1 trametinib 0.1003839 0.4967736 0.10038 NA NA
XPO1 trametinib 0.1015015 0.4967736 0.10150 NA NA
MYD88 trametinib 0.1042757 0.4967736 0.10428 NA NA
ABL1 trametinib 0.1069974 0.4967736 0.10700 NA NA
NRAS afatinib 0.0229960 0.4982469 0.0230
NA
AKT3 temozolomide 0.1716414 0.4996672 0.17164 NA NA
KRAS pazopanib 0.0043870 0.5041844 0.0044 ** NA
ABL1 pazopanib 0.0076975 0.5041844 0.0077 ** NA
FBXW7 temozolomide 0.1799955 0.5125960 0.18000 NA NA
CTLA4 temozolomide 0.1841506 0.5132710 0.18415 NA NA
AKT3 docetaxel 0.0158279 0.5144068 0.01583
NA
PAX5 temozolomide 0.1887930 0.5152476 0.18879 NA NA
GNB1 cabozantinib 0.1658940 0.5174314 0.1659 NA NA
RUNX1 docetaxel 0.0229958 0.5238674 0.02300
NA
MGMT docetaxel 0.0241785 0.5238674 0.02418
NA
CTNNB1 ruxolitinib 0.0173719 0.5335616 0.0174
NA
PAX8 ruxolitinib 0.0184880 0.5335616 0.0185
NA
MAP2K1 ruxolitinib 0.0186366 0.5335616 0.0186
NA
EZH2 ruxolitinib 0.0258155 0.5335616 0.0258
NA
PIK3CA ruxolitinib 0.0312550 0.5335616 0.0313
NA
WHSC1 ruxolitinib 0.0467507 0.5335616 0.0468
NA
RAD21 ruxolitinib 0.0481399 0.5335616 0.0481
NA
BCORL1 ruxolitinib 0.0528280 0.5335616 0.0528 NA NA
NCOA2 ruxolitinib 0.0550670 0.5335616 0.0551 NA NA
JAK1 ruxolitinib 0.0561915 0.5335616 0.0562 NA NA
CALR ruxolitinib 0.0572486 0.5335616 0.0572 NA NA
U2AF1 ruxolitinib 0.0579826 0.5335616 0.0580 NA NA
CDKN2A ruxolitinib 0.0596793 0.5335616 0.0597 NA NA
PDGFB ruxolitinib 0.0653257 0.5335616 0.0653 NA NA
ABL1 ruxolitinib 0.0661262 0.5335616 0.0661 NA NA
CYP19A1 ruxolitinib 0.0692408 0.5335616 0.0692 NA NA
NPM1 cabozantinib 0.1781069 0.5335830 0.1781 NA NA
SF1 cabozantinib 0.1792187 0.5335830 0.1792 NA NA
PAX8 cabozantinib 0.1865583 0.5338266 0.1866 NA NA
MPL cabozantinib 0.1896077 0.5338266 0.1896 NA NA
MGMT cabozantinib 0.1946541 0.5338266 0.1947 NA NA
SETD2 cabozantinib 0.1995660 0.5338266 0.1996 NA NA
GNAS cabozantinib 0.1996756 0.5338266 0.1997 NA NA
CREBBP temozolomide 0.2063925 0.5358048 0.20639 NA NA
GATA3 temozolomide 0.2077388 0.5358048 0.20774 NA NA
JAK2 temozolomide 0.2108300 0.5358048 0.21083 NA NA
RAD21 temozolomide 0.2154867 0.5358048 0.21549 NA NA
PTCH1 temozolomide 0.2167760 0.5358048 0.21678 NA NA
PML temozolomide 0.2217712 0.5380004 0.22177 NA NA
FBXW7 gefitinib 0.0379174 0.5407797 0.0379
NA
PIGA gefitinib 0.0386253 0.5407797 0.0386
NA
SF3B1 gefitinib 0.0415984 0.5407797 0.0416
NA
KRAS dabrafenib 0.0278924 0.5413795 0.02789
NA
AKT3 dabrafenib 0.0282407 0.5413795 0.02824
NA
DNAJB1 dabrafenib 0.0289287 0.5413795 0.02893
NA
NCOA2 crizotinib 0.0046821 0.5431240 0.0047 ** NA
CALR cabozantinib 0.2096259 0.5481521 0.2096 NA NA
U2AF1 cabozantinib 0.2134027 0.5481521 0.2134 NA NA
GNB1 trametinib 0.1250888 0.5484924 0.12509 NA NA
FGFR1 trametinib 0.1292149 0.5484924 0.12921 NA NA
PDGFRA trametinib 0.1350935 0.5484924 0.13509 NA NA
ALK trametinib 0.1385711 0.5484924 0.13857 NA NA
TSC2 trametinib 0.1392327 0.5484924 0.13923 NA NA
MPL temozolomide 0.2305412 0.5491073 0.23054 NA NA
GATA3 trametinib 0.1446868 0.5519437 0.14469 NA NA
IL7R trametinib 0.1502552 0.5519437 0.15026 NA NA
GNAQ trametinib 0.1547547 0.5519437 0.15475 NA NA
WHSC1 trametinib 0.1570917 0.5519437 0.15709 NA NA
NT5C2 cabozantinib 0.2249494 0.5563923 0.2249 NA NA
HRAS cabozantinib 0.2251053 0.5563923 0.2251 NA NA
GNB1 alectinib 0.0042631 0.5584650 0.0043 ** NA
BCOR trametinib 0.1650504 0.5646463 0.16505 NA NA
CD79B tretinoin 0.1643471 0.5708883 0.1643 NA NA
TP53 tretinoin 0.1673997 0.5708883 0.1674 NA NA
PDGFB tretinoin 0.1722109 0.5708883 0.1722 NA NA
PTCH1 tretinoin 0.1733580 0.5708883 0.1734 NA NA
EML4 tretinoin 0.1756579 0.5708883 0.1757 NA NA
CTNNB1 docetaxel 0.0356295 0.5709069 0.03563
NA
FGFR2 docetaxel 0.0408171 0.5709069 0.04082
NA
ATM docetaxel 0.0457127 0.5709069 0.04571
NA
CREBBP docetaxel 0.0462148 0.5709069 0.04621
NA
CRLF2 docetaxel 0.0483075 0.5709069 0.04831
NA
TSC1 trametinib 0.1714196 0.5713987 0.17142 NA NA
FGFR2 temozolomide 0.2455699 0.5744582 0.24557 NA NA
RAD21 tretinoin 0.1903979 0.5815114 0.1904 NA NA
IKZF1 tretinoin 0.1918545 0.5815114 0.1919 NA NA
CRLF2 tretinoin 0.1923461 0.5815114 0.1923 NA NA
CTCF cabozantinib 0.2443216 0.5868901 0.2443 NA NA
PDCD1 cabozantinib 0.2464043 0.5868901 0.2464 NA NA
PHF6 tretinoin 0.2045860 0.5899515 0.2046 NA NA
MDM2 tretinoin 0.2059902 0.5899515 0.2060 NA NA
CEBPA tretinoin 0.2087521 0.5899515 0.2088 NA NA
TP53 temozolomide 0.2572528 0.5912301 0.25725 NA NA
JAK2 dabrafenib 0.0362699 0.5939194 0.03627
NA
PIK3CA gefitinib 0.0505049 0.5968763 0.0505 NA NA
EGF cabozantinib 0.2557242 0.5982121 0.2557 NA NA
MDM2 docetaxel 0.0557127 0.6035542 0.05571 NA NA
FLCN ruxolitinib 0.0877965 0.6115893 0.0878 NA NA
RPL10 ruxolitinib 0.0887038 0.6115893 0.0887 NA NA
DNMT3A cabozantinib 0.2687536 0.6129888 0.2688 NA NA
GATA1 cabozantinib 0.2722065 0.6129888 0.2722 NA NA
RUNX1 cabozantinib 0.2760789 0.6129888 0.2761 NA NA
KRAS tretinoin 0.2237016 0.6146500 0.2237 NA NA
TET2 tretinoin 0.2269477 0.6146500 0.2269 NA NA
NPM1 temozolomide 0.2747200 0.6204884 0.27472 NA NA
MYD88 ruxolitinib 0.0954788 0.6253862 0.0955 NA NA
NT5C2 tretinoin 0.2358069 0.6256102 0.2358 NA NA
ERBB3 cabozantinib 0.2887403 0.6304163 0.2887 NA NA
GNAQ docetaxel 0.0658365 0.6323606 0.06584 NA NA
DNMT3A docetaxel 0.0692678 0.6323606 0.06927 NA NA
CDC73 docetaxel 0.0864333 0.6323606 0.08643 NA NA
PTEN docetaxel 0.0903770 0.6323606 0.09038 NA NA
WHSC1 docetaxel 0.0905119 0.6323606 0.09051 NA NA
ABL1 docetaxel 0.0918631 0.6323606 0.09186 NA NA
CBLB docetaxel 0.0924219 0.6323606 0.09242 NA NA
AKT2 tretinoin 0.2446468 0.6341008 0.2446 NA NA
ERBB3 tretinoin 0.2487626 0.6341008 0.2488 NA NA
HRAS tretinoin 0.2537166 0.6342916 0.2537 NA NA
CALR tretinoin 0.2599107 0.6375168 0.2599 NA NA
CBL temozolomide 0.2912507 0.6410298 0.29125 NA NA
SMC1A temozolomide 0.2977471 0.6410298 0.29775 NA NA
PIGA temozolomide 0.3013076 0.6410298 0.30131 NA NA
DNAJB1 temozolomide 0.3033881 0.6410298 0.30339 NA NA
UGT1A1 afatinib 0.0384529 0.6453715 0.0385
NA
CDKN2A afatinib 0.0397152 0.6453715 0.0397
NA
ERBB4 temozolomide 0.3115486 0.6478232 0.31155 NA NA
PAX5 ruxolitinib 0.1202681 0.6485243 0.1203 NA NA
TPMT ruxolitinib 0.1231531 0.6485243 0.1232 NA NA
RUNX1 ruxolitinib 0.1276182 0.6485243 0.1276 NA NA
JAK3 ruxolitinib 0.1351891 0.6485243 0.1352 NA NA
STAT3 ruxolitinib 0.1427439 0.6485243 0.1427 NA NA
FGFR1 ruxolitinib 0.1519639 0.6485243 0.1520 NA NA
ZRSR2 ruxolitinib 0.1522656 0.6485243 0.1523 NA NA
PRPF40B ruxolitinib 0.1533423 0.6485243 0.1533 NA NA
IKZF1 ruxolitinib 0.1536440 0.6485243 0.1536 NA NA
IL7R ruxolitinib 0.1543734 0.6485243 0.1544 NA NA
PTEN ruxolitinib 0.1566767 0.6485243 0.1567 NA NA
TET2 ruxolitinib 0.1663985 0.6485243 0.1664 NA NA
PTPN11 ruxolitinib 0.1682990 0.6485243 0.1683 NA NA
EED ruxolitinib 0.1723166 0.6485243 0.1723 NA NA
VHL ruxolitinib 0.1743680 0.6485243 0.1744 NA NA
CTCF ruxolitinib 0.1782204 0.6485243 0.1782 NA NA
EZH2 imatinib 0.0169779 0.6495160 0.017
NA
GNB1 imatinib 0.0252224 0.6495160 0.025
NA
ESR1 imatinib 0.0394429 0.6495160 0.039
NA
NCOA2 imatinib 0.0464638 0.6495160 0.046
NA
BCORL1 imatinib 0.0590039 0.6495160 0.059 NA NA
BCOR imatinib 0.0617869 0.6495160 0.062 NA NA
JAK3 imatinib 0.0632514 0.6495160 0.063 NA NA
FGFR2 imatinib 0.0731536 0.6495160 0.073 NA NA
DNAJB1 imatinib 0.0817584 0.6495160 0.082 NA NA
MDM2 imatinib 0.0872503 0.6495160 0.087 NA NA
VHL imatinib 0.0884277 0.6495160 0.088 NA NA
EML4 imatinib 0.0947179 0.6495160 0.095 NA NA
RPL10 imatinib 0.0953332 0.6495160 0.095 NA NA
FLT3 imatinib 0.0990080 0.6495160 0.099 NA NA
FLCN imatinib 0.1005378 0.6495160 0.101 NA NA
CYP19A1 imatinib 0.1086620 0.6495160 0.109 NA NA
BRCA2 imatinib 0.1174800 0.6495160 0.117 NA NA
PIGA imatinib 0.1236551 0.6495160 0.124 NA NA
RIT1 imatinib 0.1236551 0.6495160 0.124 NA NA
SMC1A imatinib 0.1238297 0.6495160 0.124 NA NA
ETV6 imatinib 0.1331229 0.6495160 0.133 NA NA
MAP2K1 imatinib 0.1429961 0.6495160 0.143 NA NA
ERBB3 imatinib 0.1453832 0.6495160 0.145 NA NA
EGF imatinib 0.1470992 0.6495160 0.147 NA NA
FANCL imatinib 0.1471141 0.6495160 0.147 NA NA
MET imatinib 0.1511805 0.6495160 0.151 NA NA
JAK2 tretinoin 0.2702044 0.6504920 0.2702 NA NA
DPYD cabozantinib 0.3047799 0.6545274 0.3048 NA NA
SRSF2 tretinoin 0.2812022 0.6569322 0.2812 NA NA
AKT3 tretinoin 0.2910595 0.6569322 0.2911 NA NA
ERBB2 tretinoin 0.3012993 0.6569322 0.3013 NA NA
BCORL1 tretinoin 0.3097124 0.6569322 0.3097 NA NA
BRAF tretinoin 0.3097622 0.6569322 0.3098 NA NA
WHSC1 tretinoin 0.3115987 0.6569322 0.3116 NA NA
MET tretinoin 0.3136957 0.6569322 0.3137 NA NA
NRAS tretinoin 0.3141618 0.6569322 0.3142 NA NA
SH2B3 tretinoin 0.3183595 0.6569322 0.3184 NA NA
GATA1 temozolomide 0.3232634 0.6616435 0.32326 NA NA
U2AF1 temozolomide 0.3282964 0.6616435 0.32830 NA NA
CD274 ruxolitinib 0.1870849 0.6623818 0.1871 NA NA
EZH2 palbociclib 0.0358492 0.6639872 0.0358
NA
GATA2 palbociclib 0.0420214 0.6639872 0.0420
NA
GATA3 palbociclib 0.0495673 0.6639872 0.0496
NA
U2AF1 palbociclib 0.0518080 0.6639872 0.0518 NA NA
CBLB palbociclib 0.0557547 0.6639872 0.0558 NA NA
CDK6 cabozantinib 0.3152330 0.6660569 0.3152 NA NA
NT5C2 imatinib 0.1629599 0.6677699 0.163 NA NA
STAG2 imatinib 0.1717038 0.6677699 0.172 NA NA
SF1 imatinib 0.1779288 0.6677699 0.178 NA NA
NPM1 imatinib 0.1935911 0.6677699 0.194 NA NA
PRPF40B imatinib 0.1984027 0.6677699 0.198 NA NA
ZRSR2 imatinib 0.1984027 0.6677699 0.198 NA NA
CD79B imatinib 0.2040208 0.6677699 0.204 NA NA
GNAQ imatinib 0.2040208 0.6677699 0.204 NA NA
CTNNB1 imatinib 0.2072389 0.6677699 0.207 NA NA
VHL erlotinib 0.0058080 0.6679176 0.0058 ** NA
BCOR temozolomide 0.3390158 0.6728951 0.33902 NA NA
PAX8 docetaxel 0.1054555 0.6738688 0.10546 NA NA
U2AF1 docetaxel 0.1088557 0.6738688 0.10886 NA NA
BRAF ruxolitinib 0.1976786 0.6771198 0.1977 NA NA
STAG2 ruxolitinib 0.2060015 0.6771198 0.2060 NA NA
MYCN ruxolitinib 0.2191911 0.6771198 0.2192 NA NA
TP53 ruxolitinib 0.2293455 0.6771198 0.2293 NA NA
ALK ruxolitinib 0.2294413 0.6771198 0.2294 NA NA
NRAS ruxolitinib 0.2306461 0.6771198 0.2306 NA NA
CEBPA ruxolitinib 0.2318168 0.6771198 0.2318 NA NA
G6PD ruxolitinib 0.2325984 0.6771198 0.2326 NA NA
JAK1 tretinoin 0.3338555 0.6781439 0.3339 NA NA
CTCF imatinib 0.2188316 0.6804247 0.219 NA NA
PAX5 imatinib 0.2228977 0.6804247 0.223 NA NA
ATM temozolomide 0.3484051 0.6812100 0.34841 NA NA
RPL10 docetaxel 0.1206554 0.6814448 0.12066 NA NA
SMO docetaxel 0.1208460 0.6814448 0.12085 NA NA
MYD88 docetaxel 0.1258052 0.6814448 0.12581 NA NA
VHL lapatinib 0.0058885 0.6830626 0.0059 ** NA
FLCN cabozantinib 0.3290045 0.6841204 0.3290 NA NA
BTK tretinoin 0.3447531 0.6860343 0.3448 NA NA
IDH2 tretinoin 0.3482943 0.6860343 0.3483 NA NA
CDK6 pazopanib 0.0157171 0.6863144 0.0157
NA
NPM1 dabrafenib 0.0506987 0.6877005 0.05070 NA NA
ERBB3 dabrafenib 0.0574180 0.6877005 0.05742 NA NA
TET2 dabrafenib 0.0577458 0.6877005 0.05775 NA NA
MAP2K1 trametinib 0.2151783 0.6898155 0.21518 NA NA
CBLB trametinib 0.2206325 0.6898155 0.22063 NA NA
U2AF1 trametinib 0.2247977 0.6898155 0.22480 NA NA
FGFR3 trametinib 0.2295042 0.6898155 0.22950 NA NA
CREBBP trametinib 0.2417435 0.6898155 0.24174 NA NA
CYP19A1 trametinib 0.2426959 0.6898155 0.24270 NA NA
DPYD trametinib 0.2458254 0.6898155 0.24583 NA NA
RET trametinib 0.2493948 0.6898155 0.24939 NA NA
SRSF2 cabozantinib 0.3392737 0.6944509 0.3393 NA NA
JAK1 palbociclib 0.0659376 0.6955119 0.0659 NA NA
SRSF2 palbociclib 0.0800824 0.6955119 0.0801 NA NA
EGF palbociclib 0.0817756 0.6955119 0.0818 NA NA
BTK palbociclib 0.0828013 0.6955119 0.0828 NA NA
RPL10 palbociclib 0.0873407 0.6955119 0.0873 NA NA
RET palbociclib 0.0983382 0.6955119 0.0983 NA NA
BRCA2 palbociclib 0.1027690 0.6955119 0.1028 NA NA
ZRSR2 palbociclib 0.1039936 0.6955119 0.1040 NA NA
BRAF palbociclib 0.1131136 0.6955119 0.1131 NA NA
FGFR1 palbociclib 0.1164096 0.6955119 0.1164 NA NA
VHL palbociclib 0.1197067 0.6955119 0.1197 NA NA
KMT2A palbociclib 0.1221128 0.6955119 0.1221 NA NA
CBLB ruxolitinib 0.2446656 0.6967651 0.2447 NA NA
GATA1 imatinib 0.2395896 0.7015219 0.240 NA NA
GATA3 imatinib 0.2473162 0.7015219 0.247 NA NA
PDGFB imatinib 0.2502352 0.7015219 0.250 NA NA
CALR imatinib 0.2539993 0.7015219 0.254 NA NA
RET docetaxel 0.1477981 0.7031832 0.14780 NA NA
CTCF docetaxel 0.1533534 0.7031832 0.15335 NA NA
NOTCH1 docetaxel 0.1690237 0.7031832 0.16902 NA NA
MAP2K1 docetaxel 0.1700087 0.7031832 0.17001 NA NA
ROS1 docetaxel 0.1704250 0.7031832 0.17043 NA NA
CALR docetaxel 0.1774390 0.7031832 0.17744 NA NA
JAK2 docetaxel 0.1783666 0.7031832 0.17837 NA NA
G6PD docetaxel 0.1822668 0.7031832 0.18227 NA NA
DDIT3 docetaxel 0.1899483 0.7031832 0.18995 NA NA
PDCD1 docetaxel 0.1924908 0.7031832 0.19249 NA NA
PHF6 docetaxel 0.1965851 0.7031832 0.19659 NA NA
TSC2 docetaxel 0.1988212 0.7031832 0.19882 NA NA
FGFR1 docetaxel 0.2138153 0.7031832 0.21382 NA NA
SF3B1 docetaxel 0.2143435 0.7031832 0.21434 NA NA
EGF docetaxel 0.2461603 0.7031832 0.24616 NA NA
GNA11 docetaxel 0.2485190 0.7031832 0.24852 NA NA
NPM1 docetaxel 0.2488101 0.7031832 0.24881 NA NA
IDH1 docetaxel 0.2558126 0.7031832 0.25581 NA NA
TPMT docetaxel 0.2626723 0.7031832 0.26267 NA NA
BRAF docetaxel 0.2666895 0.7031832 0.26669 NA NA
ZRSR2 docetaxel 0.2674973 0.7031832 0.26750 NA NA
KRAS docetaxel 0.2725554 0.7031832 0.27256 NA NA
EZH2 docetaxel 0.2774451 0.7031832 0.27745 NA NA
CTLA4 docetaxel 0.2788643 0.7031832 0.27886 NA NA
CD274 docetaxel 0.2805815 0.7031832 0.28058 NA NA
PDGFRB docetaxel 0.2818564 0.7031832 0.28186 NA NA
MPL docetaxel 0.2836659 0.7031832 0.28367 NA NA
JAK3 docetaxel 0.2865263 0.7031832 0.28653 NA NA
CXCR4 docetaxel 0.2866824 0.7031832 0.28668 NA NA
ERBB4 imatinib 0.2611044 0.7043747 0.261 NA NA
TPMT dabrafenib 0.0737570 0.7070530 0.07376 NA NA
IDH1 dabrafenib 0.0752645 0.7070530 0.07526 NA NA
RAD21 dabrafenib 0.0773282 0.7070530 0.07733 NA NA
NT5C2 dabrafenib 0.1005154 0.7070530 0.10052 NA NA
PHF6 dabrafenib 0.1087549 0.7070530 0.10875 NA NA
TSC2 dabrafenib 0.1118016 0.7070530 0.11180 NA NA
CBL dabrafenib 0.1130546 0.7070530 0.11305 NA NA
SETD2 dabrafenib 0.1138566 0.7070530 0.11386 NA NA
ATM dabrafenib 0.1159223 0.7070530 0.11592 NA NA
ALK dabrafenib 0.1254923 0.7070530 0.12549 NA NA
EGFR dabrafenib 0.1350723 0.7070530 0.13507 NA NA
MET dabrafenib 0.1361932 0.7070530 0.13619 NA NA
TP53 dabrafenib 0.1373973 0.7070530 0.13740 NA NA
CDC73 dabrafenib 0.1516303 0.7070530 0.15163 NA NA
CRLF2 dabrafenib 0.1520171 0.7070530 0.15202 NA NA
PDCD1 dabrafenib 0.1546264 0.7070530 0.15463 NA NA
ZRSR2 dabrafenib 0.1591476 0.7070530 0.15915 NA NA
CD79B dabrafenib 0.1596056 0.7070530 0.15961 NA NA
KMT2A dabrafenib 0.1680952 0.7070530 0.16810 NA NA
PIK3CA dabrafenib 0.1707493 0.7070530 0.17075 NA NA
EED dabrafenib 0.1727152 0.7070530 0.17272 NA NA
CDC73 ponatinib 0.0223079 0.7084349 0.022
NA
ERBB3 ponatinib 0.0344904 0.7084349 0.034
NA
DNAJB1 ponatinib 0.0447942 0.7084349 0.045
NA
FBXW7 ponatinib 0.0514651 0.7084349 0.051 NA NA
ABL1 ponatinib 0.0614896 0.7084349 0.061 NA NA
PIGA ponatinib 0.0621845 0.7084349 0.062 NA NA
CREBBP ponatinib 0.0643029 0.7084349 0.064 NA NA
SRSF2 ponatinib 0.0749201 0.7084349 0.075 NA NA
CSF3R ponatinib 0.0758595 0.7084349 0.076 NA NA
ASXL1 ponatinib 0.0806503 0.7084349 0.081 NA NA
FGFR2 ponatinib 0.0814419 0.7084349 0.081 NA NA
CTLA4 ponatinib 0.0856420 0.7084349 0.086 NA NA
RPL10 ponatinib 0.0860587 0.7084349 0.086 NA NA
CALR ponatinib 0.0929099 0.7084349 0.093 NA NA
IL7R ponatinib 0.0972285 0.7084349 0.097 NA NA
SH2B3 ponatinib 0.1023151 0.7084349 0.102 NA NA
CXCR4 ponatinib 0.1109241 0.7084349 0.111 NA NA
STAT3 ponatinib 0.1142358 0.7084349 0.114 NA NA
ROS1 ponatinib 0.1143242 0.7084349 0.114 NA NA
FANCL ponatinib 0.1174239 0.7084349 0.117 NA NA
EZH2 ponatinib 0.1193818 0.7084349 0.119 NA NA
CDK6 ponatinib 0.1216781 0.7084349 0.122 NA NA
CDKN2A ponatinib 0.1262284 0.7084349 0.126 NA NA
GNA11 ponatinib 0.1297896 0.7084349 0.130 NA NA
CDKN2A temozolomide 0.3683127 0.7095436 0.36831 NA NA
SETD2 imatinib 0.2695411 0.7106084 0.270 NA NA
ABL1 afatinib 0.0507264 0.7114784 0.0507 NA NA
CDK6 afatinib 0.0547291 0.7114784 0.0547 NA NA
U2AF1 imatinib 0.2938112 0.7119423 0.294 NA NA
UGT1A1 imatinib 0.2957214 0.7119423 0.296 NA NA
XPO1 imatinib 0.2979122 0.7119423 0.298 NA NA
BTK imatinib 0.2980109 0.7119423 0.298 NA NA
TSC1 imatinib 0.3108496 0.7119423 0.311 NA NA
PDGFRA imatinib 0.3143676 0.7119423 0.314 NA NA
ERBB2 imatinib 0.3160344 0.7119423 0.316 NA NA
SMC3 imatinib 0.3191465 0.7119423 0.319 NA NA
NOTCH2 nilotinib 0.0055404 0.7135301 0.0055 ** NA
RAD21 nilotinib 0.0135245 0.7135301 0.0135
NA
ETV6 nilotinib 0.0280075 0.7135301 0.0280
NA
GNAQ nilotinib 0.0300494 0.7135301 0.0300
NA
MAP2K1 nilotinib 0.0321453 0.7135301 0.0321
NA
CDC73 nilotinib 0.0329322 0.7135301 0.0329
NA
DPYD temozolomide 0.3822258 0.7153994 0.38223 NA NA
MDM2 temozolomide 0.3822745 0.7153994 0.38227 NA NA
BRCA2 erlotinib 0.0208851 0.7177003 0.0209
NA
WT1 erlotinib 0.0619633 0.7177003 0.0620 NA NA
CDK4 erlotinib 0.0672825 0.7177003 0.0673 NA NA
GNAS erlotinib 0.0775246 0.7177003 0.0775 NA NA
STAT3 erlotinib 0.0845539 0.7177003 0.0846 NA NA
FLT3 erlotinib 0.0848216 0.7177003 0.0848 NA NA
FBXW7 erlotinib 0.0858748 0.7177003 0.0859 NA NA
FGFR2 erlotinib 0.0905151 0.7177003 0.0905 NA NA
RPL10 erlotinib 0.0912646 0.7177003 0.0913 NA NA
ROS1 erlotinib 0.0943399 0.7177003 0.0943 NA NA
CRLF2 erlotinib 0.1091200 0.7177003 0.1091 NA NA
PRPF40B erlotinib 0.1140652 0.7177003 0.1141 NA NA
CBL erlotinib 0.1192013 0.7177003 0.1192 NA NA
MET erlotinib 0.1281272 0.7177003 0.1281 NA NA
MGMT erlotinib 0.1288089 0.7177003 0.1288 NA NA
FLCN erlotinib 0.1333236 0.7177003 0.1333 NA NA
CALR erlotinib 0.1340397 0.7177003 0.1340 NA NA
PAX8 erlotinib 0.1394332 0.7177003 0.1394 NA NA
FGFR1 erlotinib 0.1424666 0.7177003 0.1425 NA NA
PDGFB erlotinib 0.1449924 0.7177003 0.1450 NA NA
UGT1A1 erlotinib 0.1468898 0.7177003 0.1469 NA NA
ATM erlotinib 0.1547223 0.7177003 0.1547 NA NA
FGFR3 erlotinib 0.1556510 0.7177003 0.1557 NA NA
NRAS erlotinib 0.1660607 0.7177003 0.1661 NA NA
PAX5 erlotinib 0.1794822 0.7177003 0.1795 NA NA
PIGA erlotinib 0.1794822 0.7177003 0.1795 NA NA
NCOA2 erlotinib 0.1903671 0.7177003 0.1904 NA NA
EZH2 erlotinib 0.1974234 0.7177003 0.1974 NA NA
PDGFRB erlotinib 0.2028937 0.7177003 0.2029 NA NA
JAK1 erlotinib 0.2097544 0.7177003 0.2098 NA NA
NPM1 erlotinib 0.2158617 0.7177003 0.2159 NA NA
IL7R erlotinib 0.2186340 0.7177003 0.2186 NA NA
GATA2 erlotinib 0.2198677 0.7177003 0.2199 NA NA
RIT1 erlotinib 0.2253417 0.7177003 0.2253 NA NA
SMC1A erlotinib 0.2261745 0.7177003 0.2262 NA NA
FANCL erlotinib 0.2309123 0.7177003 0.2309 NA NA
IDH1 nilotinib 0.0386525 0.7178331 0.0387
NA
RAD21 alectinib 0.0435161 0.7190961 0.0435
NA
EML4 alectinib 0.0492773 0.7190961 0.0493
NA
RET alectinib 0.0609957 0.7190961 0.0610 NA NA
PDGFRA alectinib 0.0638924 0.7190961 0.0639 NA NA
SETBP1 alectinib 0.0668146 0.7190961 0.0668 NA NA
PTPN11 alectinib 0.0715010 0.7190961 0.0715 NA NA
NT5C2 alectinib 0.0850860 0.7190961 0.0851 NA NA
EZH2 alectinib 0.0868365 0.7190961 0.0868 NA NA
RPL10 alectinib 0.0868754 0.7190961 0.0869 NA NA
TPMT alectinib 0.0935866 0.7190961 0.0936 NA NA
CD274 alectinib 0.0945006 0.7190961 0.0945 NA NA
AKT3 alectinib 0.0987542 0.7190961 0.0988 NA NA
SMC3 alectinib 0.1109591 0.7190961 0.1110 NA NA
FLCN alectinib 0.1110717 0.7190961 0.1111 NA NA
FANCL alectinib 0.1248849 0.7190961 0.1249 NA NA
SETD2 alectinib 0.1283291 0.7190961 0.1283 NA NA
MAP2K1 alectinib 0.1306584 0.7190961 0.1307 NA NA
ASXL1 alectinib 0.1383344 0.7190961 0.1383 NA NA
EED alectinib 0.1407867 0.7190961 0.1408 NA NA
GNAQ alectinib 0.1418350 0.7190961 0.1418 NA NA
CTLA4 alectinib 0.1466805 0.7190961 0.1467 NA NA
G6PD alectinib 0.1491983 0.7190961 0.1492 NA NA
BRAF alectinib 0.1526449 0.7190961 0.1526 NA NA
IL7R alectinib 0.1558610 0.7190961 0.1559 NA NA
HRAS alectinib 0.1622969 0.7190961 0.1623 NA NA
DDIT3 alectinib 0.1687949 0.7190961 0.1688 NA NA
STAT3 alectinib 0.1812298 0.7190961 0.1812 NA NA
BRCA2 alectinib 0.1881297 0.7190961 0.1881 NA NA
CTNNB1 alectinib 0.1894137 0.7190961 0.1894 NA NA
PML alectinib 0.1950849 0.7190961 0.1951 NA NA
JAK1 alectinib 0.2001873 0.7190961 0.2002 NA NA
BCORL1 alectinib 0.2070853 0.7190961 0.2071 NA NA
GATA3 alectinib 0.2079277 0.7190961 0.2079 NA NA
PTEN alectinib 0.2092253 0.7190961 0.2092 NA NA
STAG2 alectinib 0.2144126 0.7190961 0.2144 NA NA
CEBPA alectinib 0.2230121 0.7190961 0.2230 NA NA
NPM1 alectinib 0.2246258 0.7190961 0.2246 NA NA
RIT1 alectinib 0.2291396 0.7190961 0.2291 NA NA
ROS1 alectinib 0.2335276 0.7190961 0.2335 NA NA
PDCD1 alectinib 0.2338858 0.7190961 0.2339 NA NA
JAK2 alectinib 0.2385373 0.7190961 0.2385 NA NA
TSC2 alectinib 0.2393143 0.7190961 0.2393 NA NA
VHL alectinib 0.2439120 0.7190961 0.2439 NA NA
ABL1 alectinib 0.2470177 0.7190961 0.2470 NA NA
PDGFRB dabrafenib 0.1895855 0.7211576 0.18959 NA NA
GNB1 dabrafenib 0.1924605 0.7211576 0.19246 NA NA
KIT dabrafenib 0.2027554 0.7211576 0.20276 NA NA
BCORL1 dabrafenib 0.2043963 0.7211576 0.20440 NA NA
CDK6 dabrafenib 0.2053813 0.7211576 0.20538 NA NA
GATA1 dabrafenib 0.2115052 0.7211576 0.21151 NA NA
EGF dabrafenib 0.2146958 0.7211576 0.21470 NA NA
GNAS ponatinib 0.1378710 0.7224438 0.138 NA NA
GATA2 cabozantinib 0.3602779 0.7230306 0.3603 NA NA
AR cabozantinib 0.3642750 0.7230306 0.3643 NA NA
MYCN docetaxel 0.3007324 0.7239855 0.30073 NA NA
RIT1 tretinoin 0.3778288 0.7268605 0.3778 NA NA
MPL tretinoin 0.3802579 0.7268605 0.3803 NA NA
AKT1 tretinoin 0.3944562 0.7268605 0.3945 NA NA
WT1 tretinoin 0.3981599 0.7268605 0.3982 NA NA
JAK3 tretinoin 0.3985742 0.7268605 0.3986 NA NA
CD274 tretinoin 0.4075623 0.7268605 0.4076 NA NA
PML tretinoin 0.4081601 0.7268605 0.4082 NA NA
RAD21 trametinib 0.2729462 0.7270095 0.27295 NA NA
ERBB2 trametinib 0.2740267 0.7270095 0.27403 NA NA
NT5C2 palbociclib 0.1332752 0.7274606 0.1333 NA NA
ALK temozolomide 0.4005886 0.7314423 0.40059 NA NA
FGFR1 temozolomide 0.4020141 0.7314423 0.40201 NA NA
BRAF imatinib 0.3365852 0.7332278 0.337 NA NA
IKZF1 imatinib 0.3413302 0.7332278 0.341 NA NA
XPO1 docetaxel 0.3105293 0.7339784 0.31053 NA NA
SF1 docetaxel 0.3162400 0.7341286 0.31624 NA NA
FGFR3 docetaxel 0.3221893 0.7348178 0.32219 NA NA
PDCD1 ruxolitinib 0.2638283 0.7353513 0.2638 NA NA
IDH2 docetaxel 0.3288933 0.7371745 0.32889 NA NA
GNAQ dabrafenib 0.2310189 0.7373099 0.23102 NA NA
CXCR4 dabrafenib 0.2424069 0.7373099 0.24241 NA NA
G6PD dabrafenib 0.2443393 0.7373099 0.24434 NA NA
SH2B3 dabrafenib 0.2453136 0.7373099 0.24531 NA NA
ERBB2 dabrafenib 0.2521562 0.7373099 0.25216 NA NA
PML dabrafenib 0.2532744 0.7373099 0.25327 NA NA
CTCF gefitinib 0.0736147 0.7376340 0.0736 NA NA
ZRSR2 gefitinib 0.0752776 0.7376340 0.0753 NA NA
ALK gefitinib 0.0794375 0.7376340 0.0794 NA NA
AR ruxolitinib 0.2707866 0.7390218 0.2708 NA NA
RPL10 afatinib 0.0872294 0.7408454 0.0872 NA NA
CBL afatinib 0.0971709 0.7408454 0.0972 NA NA
TP53 afatinib 0.1112751 0.7408454 0.1113 NA NA
XPO1 afatinib 0.1226343 0.7408454 0.1226 NA NA
MGMT afatinib 0.1228036 0.7408454 0.1228 NA NA
NOTCH2 afatinib 0.1313985 0.7408454 0.1314 NA NA
GATA1 afatinib 0.1322836 0.7408454 0.1323 NA NA
PDGFRA afatinib 0.1332170 0.7408454 0.1332 NA NA
FGFR3 afatinib 0.1440811 0.7408454 0.1441 NA NA
MAP2K1 afatinib 0.1443384 0.7408454 0.1443 NA NA
EZH2 afatinib 0.1496126 0.7408454 0.1496 NA NA
TSC2 afatinib 0.1594651 0.7408454 0.1595 NA NA
IDH2 afatinib 0.1625545 0.7408454 0.1626 NA NA
FBXW7 afatinib 0.1685081 0.7408454 0.1685 NA NA
PAX5 afatinib 0.1796773 0.7408454 0.1797 NA NA
ZRSR2 afatinib 0.1797553 0.7408454 0.1798 NA NA
FGFR1 afatinib 0.1808783 0.7408454 0.1809 NA NA
MYD88 afatinib 0.1823685 0.7408454 0.1824 NA NA
KRAS afatinib 0.1838668 0.7408454 0.1839 NA NA
MET afatinib 0.1841947 0.7408454 0.1842 NA NA
ALK afatinib 0.1885392 0.7408454 0.1885 NA NA
RIT1 afatinib 0.1891551 0.7408454 0.1892 NA NA
BCORL1 afatinib 0.2049112 0.7408454 0.2049 NA NA
RAD21 afatinib 0.2088507 0.7408454 0.2089 NA NA
CTNNB1 afatinib 0.2104143 0.7408454 0.2104 NA NA
G6PD afatinib 0.2109900 0.7408454 0.2110 NA NA
PDGFB afatinib 0.2297013 0.7408454 0.2297 NA NA
MDM2 afatinib 0.2429813 0.7408454 0.2430 NA NA
BTK afatinib 0.2500025 0.7408454 0.2500 NA NA
BRCA2 afatinib 0.2553180 0.7408454 0.2553 NA NA
CTLA4 afatinib 0.2557520 0.7408454 0.2558 NA NA
SH2B3 afatinib 0.2597980 0.7408454 0.2598 NA NA
ERBB4 afatinib 0.2599147 0.7408454 0.2599 NA NA
SF3B1 afatinib 0.2607779 0.7408454 0.2608 NA NA
PTCH1 afatinib 0.2628105 0.7408454 0.2628 NA NA
DNMT3A afatinib 0.2639824 0.7408454 0.2640 NA NA
CDC73 afatinib 0.2743006 0.7408454 0.2743 NA NA
SRSF2 afatinib 0.2781061 0.7408454 0.2781 NA NA
PIGA afatinib 0.2792417 0.7408454 0.2792 NA NA
MAP2K1 cabozantinib 0.3789920 0.7410143 0.3790 NA NA
CDKN2A alectinib 0.2605683 0.7420533 0.2606 NA NA
ERBB2 gefitinib 0.0989296 0.7427156 0.0989 NA NA
RPL10 gefitinib 0.1035789 0.7427156 0.1036 NA NA
CXCR4 gefitinib 0.1064188 0.7427156 0.1064 NA NA
PDGFRA gefitinib 0.1077698 0.7427156 0.1078 NA NA
SRSF2 gefitinib 0.1142775 0.7427156 0.1143 NA NA
GATA1 gefitinib 0.1169619 0.7427156 0.1170 NA NA
NRAS gefitinib 0.1262378 0.7427156 0.1262 NA NA
MGMT gefitinib 0.1263998 0.7427156 0.1264 NA NA
PTCH1 gefitinib 0.1346354 0.7427156 0.1346 NA NA
CREBBP gefitinib 0.1371167 0.7427156 0.1371 NA NA
KIT ruxolitinib 0.2812051 0.7487302 0.2812 NA NA
CDK6 ruxolitinib 0.2857749 0.7487302 0.2858 NA NA
NRAS dabrafenib 0.2669909 0.7501833 0.26699 NA NA
DPYD dabrafenib 0.2691497 0.7501833 0.26915 NA NA
CSF3R trametinib 0.2947229 0.7517448 0.29472 NA NA
FLT3 trametinib 0.2977892 0.7517448 0.29779 NA NA
ASXL1 trametinib 0.3050617 0.7517448 0.30506 NA NA
BTK trametinib 0.3064806 0.7517448 0.30648 NA NA
BRCA2 midostaurin 0.0058907 0.7519282 0.0059 ** NA
PTEN midostaurin 0.0178005 0.7519282 0.0178
NA
CREBBP midostaurin 0.0242074 0.7519282 0.0242
NA
EGF midostaurin 0.0320598 0.7519282 0.0321
NA
GNAS midostaurin 0.0345520 0.7519282 0.0346
NA
UGT1A1 midostaurin 0.0385592 0.7519282 0.0386
NA
FGFR1 midostaurin 0.0551905 0.7519282 0.0552 NA NA
SETD2 midostaurin 0.0586843 0.7519282 0.0587 NA NA
BCORL1 midostaurin 0.0699458 0.7519282 0.0699 NA NA
PRPF8 midostaurin 0.0781692 0.7519282 0.0782 NA NA
PIK3CA midostaurin 0.0837587 0.7519282 0.0838 NA NA
CTNNB1 midostaurin 0.0843253 0.7519282 0.0843 NA NA
RPL10 midostaurin 0.0870012 0.7519282 0.0870 NA NA
PDGFRB midostaurin 0.0887296 0.7519282 0.0887 NA NA
SRSF2 midostaurin 0.0908838 0.7519282 0.0909 NA NA
WT1 midostaurin 0.0964995 0.7519282 0.0965 NA NA
BCOR midostaurin 0.1045093 0.7519282 0.1045 NA NA
PML midostaurin 0.1046555 0.7519282 0.1047 NA NA
ERBB3 midostaurin 0.1104412 0.7519282 0.1104 NA NA
ERBB2 midostaurin 0.1231748 0.7519282 0.1232 NA NA
PTCH1 midostaurin 0.1266216 0.7519282 0.1266 NA NA
ATM midostaurin 0.1408355 0.7519282 0.1408 NA NA
AKT1 midostaurin 0.1419954 0.7519282 0.1420 NA NA
AKT3 midostaurin 0.1590833 0.7519282 0.1591 NA NA
CALR midostaurin 0.1612397 0.7519282 0.1612 NA NA
BRCA1 midostaurin 0.1683042 0.7519282 0.1683 NA NA
VHL midostaurin 0.1715663 0.7519282 0.1716 NA NA
SMC3 midostaurin 0.1875982 0.7519282 0.1876 NA NA
TSC1 midostaurin 0.1925940 0.7519282 0.1926 NA NA
NPM1 midostaurin 0.1944832 0.7519282 0.1945 NA NA
FGFR3 midostaurin 0.1981794 0.7519282 0.1982 NA NA
CEBPA midostaurin 0.1997120 0.7519282 0.1997 NA NA
PRPF40B midostaurin 0.2032107 0.7519282 0.2032 NA NA
MAP2K2 midostaurin 0.2109847 0.7519282 0.2110 NA NA
MPL midostaurin 0.2151839 0.7519282 0.2152 NA NA
IKZF1 midostaurin 0.2196854 0.7519282 0.2197 NA NA
PTPN11 midostaurin 0.2220450 0.7519282 0.2220 NA NA
MDM2 midostaurin 0.2236312 0.7519282 0.2236 NA NA
GATA1 midostaurin 0.2317022 0.7519282 0.2317 NA NA
IL7R midostaurin 0.2368814 0.7519282 0.2369 NA NA
DNAJB1 midostaurin 0.2553242 0.7519282 0.2553 NA NA
CD274 midostaurin 0.2584055 0.7519282 0.2584 NA NA
CSF3R midostaurin 0.2617885 0.7519282 0.2618 NA NA
MGMT midostaurin 0.2670503 0.7519282 0.2671 NA NA
TET2 midostaurin 0.2773549 0.7519282 0.2774 NA NA
GNA11 midostaurin 0.2792650 0.7519282 0.2793 NA NA
JAK1 midostaurin 0.2818427 0.7519282 0.2818 NA NA
PDGFRA midostaurin 0.2883532 0.7519282 0.2884 NA NA
CDK6 midostaurin 0.2899976 0.7519282 0.2900 NA NA
PIGA midostaurin 0.2909512 0.7519282 0.2910 NA NA
KRAS midostaurin 0.2927354 0.7519282 0.2927 NA NA
XPO1 ruxolitinib 0.3027717 0.7528139 0.3028 NA NA
AKT1 ruxolitinib 0.3044779 0.7528139 0.3045 NA NA
TSC1 ruxolitinib 0.3045736 0.7528139 0.3046 NA NA
EGFR alectinib 0.2707820 0.7547328 0.2708 NA NA
MDM2 alectinib 0.2810211 0.7579011 0.2810 NA NA
CD79B alectinib 0.2908767 0.7579011 0.2909 NA NA
AKT1 alectinib 0.2956410 0.7579011 0.2956 NA NA
FGFR1 alectinib 0.3000040 0.7579011 0.3000 NA NA
JAK3 alectinib 0.3008462 0.7579011 0.3008 NA NA
CSF3R dabrafenib 0.2822100 0.7588163 0.28221 NA NA
CTNNB1 dabrafenib 0.2892579 0.7588163 0.28926 NA NA
CD274 dabrafenib 0.2936109 0.7588163 0.29361 NA NA
SETBP1 dabrafenib 0.2954170 0.7588163 0.29542 NA NA
NOTCH2 rucaparib 0.0108793 0.7594594 0.011
NA
EZH2 rucaparib 0.0182099 0.7594594 0.018
NA
ZRSR2 rucaparib 0.0409566 0.7594594 0.041
NA
MAP2K2 rucaparib 0.0415245 0.7594594 0.042
NA
TSC1 rucaparib 0.0503265 0.7594594 0.050 NA NA
TP53 rucaparib 0.0614824 0.7594594 0.061 NA NA
GNAQ rucaparib 0.0616841 0.7594594 0.062 NA NA
GNB1 rucaparib 0.0624029 0.7594594 0.062 NA NA
SSX1 rucaparib 0.0860961 0.7594594 0.086 NA NA
PTPN11 rucaparib 0.0881492 0.7594594 0.088 NA NA
VHL rucaparib 0.0888741 0.7594594 0.089 NA NA
PTEN rucaparib 0.0938970 0.7594594 0.094 NA NA
DNMT3A rucaparib 0.0975186 0.7594594 0.098 NA NA
MDM2 rucaparib 0.1105299 0.7594594 0.111 NA NA
PIK3CA rucaparib 0.1220643 0.7594594 0.122 NA NA
EED rucaparib 0.1231156 0.7594594 0.123 NA NA
NOTCH1 rucaparib 0.1306394 0.7594594 0.131 NA NA
JAK3 rucaparib 0.1342473 0.7594594 0.134 NA NA
CDKN2A rucaparib 0.1382694 0.7594594 0.138 NA NA
BRAF rucaparib 0.1413053 0.7594594 0.141 NA NA
RIT1 rucaparib 0.1426020 0.7594594 0.143 NA NA
PRPF8 rucaparib 0.1466626 0.7594594 0.147 NA NA
IL7R rucaparib 0.1489089 0.7594594 0.149 NA NA
IDH2 rucaparib 0.1502920 0.7594594 0.150 NA NA
AKT2 rucaparib 0.1688628 0.7594594 0.169 NA NA
AR rucaparib 0.1732681 0.7594594 0.173 NA NA
RPL10 rucaparib 0.1749059 0.7594594 0.175 NA NA
CBLB rucaparib 0.1753511 0.7594594 0.175 NA NA
CD274 rucaparib 0.1767650 0.7594594 0.177 NA NA
SMC3 rucaparib 0.1824393 0.7594594 0.182 NA NA
GNA11 rucaparib 0.1867700 0.7594594 0.187 NA NA
CDC73 rucaparib 0.1947424 0.7594594 0.195 NA NA
CALR rucaparib 0.1970713 0.7594594 0.197 NA NA
FLT3 rucaparib 0.1971116 0.7594594 0.197 NA NA
MAP2K2 palbociclib 0.1451389 0.7601489 0.1451 NA NA
HRAS palbociclib 0.1615122 0.7601489 0.1615 NA NA
CDK4 palbociclib 0.1723047 0.7601489 0.1723 NA NA
MDM2 palbociclib 0.1794132 0.7601489 0.1794 NA NA
GATA1 palbociclib 0.1856767 0.7601489 0.1857 NA NA
SSX1 palbociclib 0.1877964 0.7601489 0.1878 NA NA
CRLF2 palbociclib 0.1904735 0.7601489 0.1905 NA NA
UGT1A1 palbociclib 0.2007621 0.7601489 0.2008 NA NA
PML palbociclib 0.2018104 0.7601489 0.2018 NA NA
ERBB4 palbociclib 0.2071288 0.7601489 0.2071 NA NA
ABL1 palbociclib 0.2122468 0.7601489 0.2122 NA NA
PDCD1 palbociclib 0.2138133 0.7601489 0.2138 NA NA
ESR1 palbociclib 0.2146985 0.7601489 0.2147 NA NA
MAP2K2 trametinib 0.3188070 0.7603269 0.31881 NA NA
EGF trametinib 0.3216768 0.7603269 0.32168 NA NA
PRPF8 tretinoin 0.4328990 0.7604982 0.4329 NA NA
PTPN11 docetaxel 0.3505582 0.7609892 0.35056 NA NA
CDK4 docetaxel 0.3512258 0.7609892 0.35123 NA NA
KMT2A imatinib 0.3610200 0.7614240 0.361 NA NA
CEBPA palbociclib 0.2217988 0.7616445 0.2218 NA NA
DDIT3 palbociclib 0.2290040 0.7616445 0.2290 NA NA
MGMT palbociclib 0.2389195 0.7616445 0.2389 NA NA
RIT1 palbociclib 0.2411715 0.7616445 0.2412 NA NA
RAD21 palbociclib 0.2494293 0.7616445 0.2494 NA NA
NRAS palbociclib 0.2500055 0.7616445 0.2500 NA NA
U2AF1 rucaparib 0.2035438 0.7618353 0.204 NA NA
PTCH1 docetaxel 0.3578141 0.7625547 0.35781 NA NA
SMC1A cabozantinib 0.3971299 0.7626517 0.3971 NA NA
BCORL1 cabozantinib 0.4040076 0.7626517 0.4040 NA NA
ASXL1 cabozantinib 0.4107168 0.7626517 0.4107 NA NA
CDC73 cabozantinib 0.4149638 0.7626517 0.4150 NA NA
AKT3 cabozantinib 0.4216866 0.7626517 0.4217 NA NA
PIGA cabozantinib 0.4249891 0.7626517 0.4250 NA NA
KIT nilotinib 0.0509383 0.7627601 0.0509 NA NA
STAT3 nilotinib 0.0689287 0.7627601 0.0689 NA NA
TSC1 nilotinib 0.0779898 0.7627601 0.0780 NA NA
SF3B1 nilotinib 0.0801719 0.7627601 0.0802 NA NA
AKT1 nilotinib 0.0856959 0.7627601 0.0857 NA NA
DDIT3 nilotinib 0.0871195 0.7627601 0.0871 NA NA
RPL10 nilotinib 0.0874302 0.7627601 0.0874 NA NA
DNAJB1 nilotinib 0.1060679 0.7627601 0.1061 NA NA
TET2 nilotinib 0.1073900 0.7627601 0.1074 NA NA
XPO1 nilotinib 0.1080468 0.7627601 0.1080 NA NA
CTLA4 nilotinib 0.1201225 0.7627601 0.1201 NA NA
TSC2 nilotinib 0.1328358 0.7627601 0.1328 NA NA
JAK3 nilotinib 0.1339154 0.7627601 0.1339 NA NA
PDGFRA nilotinib 0.1346957 0.7627601 0.1347 NA NA
MPL nilotinib 0.1396520 0.7627601 0.1397 NA NA
CTNNB1 nilotinib 0.1455938 0.7627601 0.1456 NA NA
CALR nilotinib 0.1528002 0.7627601 0.1528 NA NA
FLT3 nilotinib 0.1535908 0.7627601 0.1536 NA NA
EZH2 nilotinib 0.1537478 0.7627601 0.1537 NA NA
ESR1 nilotinib 0.1779167 0.7627601 0.1779 NA NA
GNAS nilotinib 0.1788003 0.7627601 0.1788 NA NA
DNMT3A nilotinib 0.1870610 0.7627601 0.1871 NA NA
PDCD1 nilotinib 0.1981914 0.7627601 0.1982 NA NA
SETBP1 nilotinib 0.1987831 0.7627601 0.1988 NA NA
GNB1 nilotinib 0.2017232 0.7627601 0.2017 NA NA
STAG2 nilotinib 0.2125771 0.7627601 0.2126 NA NA
IKZF1 nilotinib 0.2133452 0.7627601 0.2133 NA NA
NT5C2 nilotinib 0.2223316 0.7627601 0.2223 NA NA
FANCL nilotinib 0.2322908 0.7627601 0.2323 NA NA
HRAS nilotinib 0.2403406 0.7627601 0.2403 NA NA
U2AF1 nilotinib 0.2644922 0.7627601 0.2645 NA NA
TPMT nilotinib 0.2737875 0.7627601 0.2738 NA NA
PDGFRB nilotinib 0.2738696 0.7627601 0.2739 NA NA
PDGFB nilotinib 0.2752114 0.7627601 0.2752 NA NA
SRSF2 nilotinib 0.2812050 0.7627601 0.2812 NA NA
RIT1 nilotinib 0.2868250 0.7627601 0.2868 NA NA
PRPF40B nilotinib 0.3059911 0.7627601 0.3060 NA NA
PTCH1 nilotinib 0.3093982 0.7627601 0.3094 NA NA
CXCR4 nilotinib 0.3164078 0.7627601 0.3164 NA NA
SMO nilotinib 0.3168786 0.7627601 0.3169 NA NA
ZRSR2 nilotinib 0.3197215 0.7627601 0.3197 NA NA
NPM1 nilotinib 0.3197255 0.7627601 0.3197 NA NA
PIK3CA nilotinib 0.3221612 0.7627601 0.3222 NA NA
ERBB2 nilotinib 0.3322155 0.7627601 0.3322 NA NA
ROS1 nilotinib 0.3339538 0.7627601 0.3340 NA NA
BCORL1 nilotinib 0.3383996 0.7627601 0.3384 NA NA
SH2B3 nilotinib 0.3391378 0.7627601 0.3391 NA NA
WHSC1 nilotinib 0.3455546 0.7627601 0.3456 NA NA
NCOA2 nilotinib 0.3469922 0.7627601 0.3470 NA NA
EGF nilotinib 0.3526555 0.7627601 0.3527 NA NA
SETD2 nilotinib 0.3549033 0.7627601 0.3549 NA NA
CBL nilotinib 0.3567703 0.7627601 0.3568 NA NA
BRAF nilotinib 0.3579029 0.7627601 0.3579 NA NA
TP53 nilotinib 0.3614059 0.7627601 0.3614 NA NA
ATM nilotinib 0.3703913 0.7627601 0.3704 NA NA
G6PD nilotinib 0.3817505 0.7627601 0.3818 NA NA
CTCF nilotinib 0.3876743 0.7627601 0.3877 NA NA
GATA1 nilotinib 0.3965339 0.7627601 0.3965 NA NA
CYP19A1 nilotinib 0.3966596 0.7627601 0.3967 NA NA
SF1 nilotinib 0.3986195 0.7627601 0.3986 NA NA
VHL nilotinib 0.4061768 0.7627601 0.4062 NA NA
RUNX1 nilotinib 0.4072745 0.7627601 0.4073 NA NA
GNA11 nilotinib 0.4200233 0.7627601 0.4200 NA NA
BRCA1 nilotinib 0.4230452 0.7627601 0.4230 NA NA
KMT2A nilotinib 0.4270492 0.7627601 0.4270 NA NA
PTPN11 nilotinib 0.4343504 0.7627601 0.4344 NA NA
NRAS nilotinib 0.4375929 0.7627601 0.4376 NA NA
MYD88 nilotinib 0.4453090 0.7627601 0.4453 NA NA
CD274 nilotinib 0.4563967 0.7627601 0.4564 NA NA
JAK2 nilotinib 0.4609294 0.7627601 0.4609 NA NA
MET nilotinib 0.4620552 0.7627601 0.4621 NA NA
EML4 nilotinib 0.4635234 0.7627601 0.4635 NA NA
SF3B1 midostaurin 0.3064956 0.7635258 0.3065 NA NA
FBXW7 midostaurin 0.3089074 0.7635258 0.3089 NA NA
CDK6 temozolomide 0.4260949 0.7646361 0.42609 NA NA
GNAS alectinib 0.3097168 0.7655264 0.3097 NA NA
PDGFB temozolomide 0.4372281 0.7683307 0.43723 NA NA
FLT3 temozolomide 0.4398840 0.7683307 0.43988 NA NA
AKT2 erlotinib 0.2541238 0.7690587 0.2541 NA NA
SSX1 tretinoin 0.4437195 0.7691137 0.4437 NA NA
G6PD tretinoin 0.4531080 0.7692065 0.4531 NA NA
VHL tretinoin 0.4556069 0.7692065 0.4556 NA NA
SF1 alectinib 0.3234420 0.7717293 0.3234 NA NA
SSX1 alectinib 0.3293082 0.7717293 0.3293 NA NA
GATA1 alectinib 0.3310119 0.7717293 0.3310 NA NA
KMT2A alectinib 0.3437441 0.7717293 0.3437 NA NA
BTK alectinib 0.3449044 0.7717293 0.3449 NA NA
BRCA1 alectinib 0.3475727 0.7717293 0.3476 NA NA
ZRSR2 temozolomide 0.4480301 0.7719287 0.44803 NA NA
MYD88 temozolomide 0.4590388 0.7719287 0.45904 NA NA
KIT temozolomide 0.4596217 0.7719287 0.45962 NA NA
TSC2 palbociclib 0.2593090 0.7720335 0.2593 NA NA
MDM2 dabrafenib 0.3064629 0.7720508 0.30646 NA NA
SMC1A midostaurin 0.3236533 0.7723736 0.3237 NA NA
FGFR2 midostaurin 0.3242790 0.7723736 0.3243 NA NA
PTPN11 ponatinib 0.1536929 0.7743760 0.154 NA NA
EGFR midostaurin 0.3312793 0.7749570 0.3313 NA NA
WHSC1 imatinib 0.3820492 0.7780805 0.382 NA NA
RET imatinib 0.3884249 0.7780805 0.388 NA NA
SMO imatinib 0.3890402 0.7780805 0.389 NA NA
NOTCH2 cabozantinib 0.4395724 0.7781619 0.4396 NA NA
CYP19A1 alectinib 0.3564980 0.7783540 0.3565 NA NA
BCORL1 docetaxel 0.3721966 0.7804122 0.37220 NA NA
BCOR nilotinib 0.4843638 0.7821006 0.4844 NA NA
UGT1A1 nilotinib 0.4918297 0.7821006 0.4918 NA NA
AR nilotinib 0.4970145 0.7821006 0.4970 NA NA
EGFR nilotinib 0.4993412 0.7821006 0.4993 NA NA
ATM imatinib 0.4026488 0.7843764 0.403 NA NA
TP53 imatinib 0.4057119 0.7843764 0.406 NA NA
GNA11 cabozantinib 0.4525437 0.7855968 0.4525 NA NA
FGFR3 cabozantinib 0.4557661 0.7855968 0.4558 NA NA
CTCF alectinib 0.3665010 0.7870759 0.3665 NA NA
PAX5 docetaxel 0.3815151 0.7872535 0.38152 NA NA
FANCL palbociclib 0.2705871 0.7877090 0.2706 NA NA
CDK6 nilotinib 0.5134963 0.7911873 0.5135 NA NA
IL7R nilotinib 0.5173148 0.7911873 0.5173 NA NA
PTEN palbociclib 0.2856346 0.7915761 0.2856 NA NA
NCOA2 palbociclib 0.2859635 0.7915761 0.2860 NA NA
MET palbociclib 0.2900431 0.7915761 0.2900 NA NA
ERBB3 nilotinib 0.5371710 0.7921853 0.5372 NA NA
MAP2K2 nilotinib 0.5386936 0.7921853 0.5387 NA NA
FGFR2 nilotinib 0.5398280 0.7921853 0.5398 NA NA
PIGA nilotinib 0.5423423 0.7921853 0.5423 NA NA
MYD88 tretinoin 0.4774785 0.7957975 0.4775 NA NA
MAP2K2 ruxolitinib 0.3295676 0.7995065 0.3296 NA NA
AR trametinib 0.3489364 0.8000202 0.34894 NA NA
CEBPA trametinib 0.3520319 0.8000202 0.35203 NA NA
ERBB4 trametinib 0.3576230 0.8000202 0.35762 NA NA
RUNX1 trametinib 0.3720382 0.8000202 0.37204 NA NA
PRPF40B trametinib 0.3750237 0.8000202 0.37502 NA NA
PIGA trametinib 0.3753941 0.8000202 0.37539 NA NA
PTCH1 alectinib 0.3832319 0.8020837 0.3832 NA NA
PAX8 alectinib 0.3871065 0.8020837 0.3871 NA NA
TSC1 alectinib 0.3956481 0.8020837 0.3956 NA NA
AKT2 alectinib 0.4024812 0.8020837 0.4025 NA NA
ERBB4 alectinib 0.4041032 0.8020837 0.4041 NA NA
SMC3 ruxolitinib 0.3368205 0.8022453 0.3368 NA NA
FLT3 crizotinib 0.0371049 0.8032944 0.0371
NA
TSC1 crizotinib 0.0396633 0.8032944 0.0397
NA
BRCA2 crizotinib 0.0408902 0.8032944 0.0409
NA
DNMT3A crizotinib 0.0577322 0.8032944 0.0577 NA NA
PML crizotinib 0.0605225 0.8032944 0.0605 NA NA
EZH2 crizotinib 0.0741267 0.8032944 0.0741 NA NA
DPYD crizotinib 0.0771266 0.8032944 0.0771 NA NA
ERBB2 crizotinib 0.0782120 0.8032944 0.0782 NA NA
RPL10 crizotinib 0.0879509 0.8032944 0.0880 NA NA
FLCN crizotinib 0.0928500 0.8032944 0.0929 NA NA
GNB1 crizotinib 0.0953243 0.8032944 0.0953 NA NA
SETBP1 crizotinib 0.1040172 0.8032944 0.1040 NA NA
XPO1 crizotinib 0.1179406 0.8032944 0.1179 NA NA
GATA3 crizotinib 0.1184833 0.8032944 0.1185 NA NA
MDM2 crizotinib 0.1214898 0.8032944 0.1215 NA NA
CDK6 crizotinib 0.1242377 0.8032944 0.1242 NA NA
MET crizotinib 0.1305419 0.8032944 0.1305 NA NA
ATM crizotinib 0.1315741 0.8032944 0.1316 NA NA
IKZF1 trametinib 0.3988024 0.8035274 0.39880 NA NA
DDIT3 trametinib 0.3990678 0.8035274 0.39907 NA NA
CTNNB1 trametinib 0.4064703 0.8035274 0.40647 NA NA
IDH2 trametinib 0.4108540 0.8035274 0.41085 NA NA
BRCA1 trametinib 0.4159320 0.8035274 0.41593 NA NA
DNMT3A trametinib 0.4166812 0.8035274 0.41668 NA NA
MDM2 trametinib 0.4203066 0.8035274 0.42031 NA NA
CTCF rucaparib 0.2351418 0.8068481 0.235 NA NA
RAD21 rucaparib 0.2491994 0.8068481 0.249 NA NA
EML4 rucaparib 0.2555029 0.8068481 0.256 NA NA
RUNX1 rucaparib 0.2593719 0.8068481 0.259 NA NA
BCOR rucaparib 0.2627595 0.8068481 0.263 NA NA
PIGA rucaparib 0.2683194 0.8068481 0.268 NA NA
NCOA2 rucaparib 0.2744830 0.8068481 0.274 NA NA
JAK2 rucaparib 0.2799799 0.8068481 0.280 NA NA
CDK6 rucaparib 0.2907652 0.8068481 0.291 NA NA
CBL rucaparib 0.2974374 0.8068481 0.297 NA NA
SF3B1 rucaparib 0.3037310 0.8068481 0.304 NA NA
MGMT rucaparib 0.3112521 0.8068481 0.311 NA NA
BRCA2 rucaparib 0.3140675 0.8068481 0.314 NA NA
ESR1 rucaparib 0.3155348 0.8068481 0.316 NA NA
KIT rucaparib 0.3176892 0.8068481 0.318 NA NA
ROS1 rucaparib 0.3210092 0.8068481 0.321 NA NA
IDH1 rucaparib 0.3365827 0.8068481 0.337 NA NA
GNAS rucaparib 0.3392393 0.8068481 0.339 NA NA
PDGFRB rucaparib 0.3399009 0.8068481 0.340 NA NA
MYD88 rucaparib 0.3422485 0.8068481 0.342 NA NA
DPYD rucaparib 0.3449122 0.8068481 0.345 NA NA
GATA2 tretinoin 0.4920281 0.8074716 0.4920 NA NA
RET tretinoin 0.4969056 0.8074716 0.4969 NA NA
PRPF8 imatinib 0.4337483 0.8076933 0.434 NA NA
DNMT3A imatinib 0.4384088 0.8076933 0.438 NA NA
IDH1 imatinib 0.4567885 0.8076933 0.457 NA NA
MYCN imatinib 0.4567885 0.8076933 0.457 NA NA
PML imatinib 0.4608455 0.8076933 0.461 NA NA
ABL1 imatinib 0.4679914 0.8076933 0.468 NA NA
PDGFRB imatinib 0.4699331 0.8076933 0.470 NA NA
CDKN2A imatinib 0.4734754 0.8076933 0.473 NA NA
DPYD afatinib 0.3107947 0.8080661 0.3108 NA NA
BRAF bosutinib monohydrate 0.0181741 0.8090479 0.0182
NA
KIT bosutinib monohydrate 0.0186703 0.8090479 0.0187
NA
NT5C2 temozolomide 0.5024237 0.8096138 0.50242 NA NA
MYCN temozolomide 0.5105673 0.8096138 0.51057 NA NA
EGF temozolomide 0.5143110 0.8096138 0.51431 NA NA
PDGFRB temozolomide 0.5143244 0.8096138 0.51432 NA NA
PTPN11 temozolomide 0.5198840 0.8096138 0.51988 NA NA
CXCR4 temozolomide 0.5324701 0.8096138 0.53247 NA NA
BRCA2 temozolomide 0.5416844 0.8096138 0.54168 NA NA
WT1 temozolomide 0.5429937 0.8096138 0.54299 NA NA
JAK3 temozolomide 0.5436890 0.8096138 0.54369 NA NA
SF1 temozolomide 0.5448516 0.8096138 0.54485 NA NA
UGT1A1 temozolomide 0.5500430 0.8096138 0.55004 NA NA
CBLB cabozantinib 0.4931138 0.8101575 0.4931 NA NA
MYD88 cabozantinib 0.4985291 0.8101575 0.4985 NA NA
RET cabozantinib 0.4991041 0.8101575 0.4991 NA NA
FANCL cabozantinib 0.5034590 0.8101575 0.5035 NA NA
CEBPA cabozantinib 0.5051263 0.8101575 0.5051 NA NA
DDIT3 cabozantinib 0.5071215 0.8101575 0.5071 NA NA
CBL crizotinib 0.1406039 0.8112139 0.1406 NA NA
CDK4 crizotinib 0.1634861 0.8112139 0.1635 NA NA
GATA1 crizotinib 0.1678222 0.8112139 0.1678 NA NA
TSC2 crizotinib 0.1757036 0.8112139 0.1757 NA NA
VHL crizotinib 0.1771829 0.8112139 0.1772 NA NA
RAD21 crizotinib 0.1897781 0.8112139 0.1898 NA NA
ERBB4 crizotinib 0.1962570 0.8112139 0.1963 NA NA
CTCF crizotinib 0.1973464 0.8112139 0.1973 NA NA
PAX5 crizotinib 0.2046329 0.8112139 0.2046 NA NA
PDCD1 crizotinib 0.2092666 0.8112139 0.2093 NA NA
EGFR crizotinib 0.2113667 0.8112139 0.2114 NA NA
MAP2K1 crizotinib 0.2167899 0.8112139 0.2168 NA NA
MGMT dabrafenib 0.3282216 0.8112646 0.32822 NA NA
AKT2 docetaxel 0.4005242 0.8120650 0.40052 NA NA
PDGFB docetaxel 0.4060325 0.8120650 0.40603 NA NA
IKZF1 docetaxel 0.4191295 0.8133959 0.41913 NA NA
FBXW7 docetaxel 0.4241498 0.8133959 0.42415 NA NA
ESR1 docetaxel 0.4254686 0.8133959 0.42547 NA NA
CTCF tretinoin 0.5098762 0.8149907 0.5099 NA NA
PIK3CA tretinoin 0.5140711 0.8149907 0.5141 NA NA
PHF6 imatinib 0.4884193 0.8160981 0.488 NA NA
PDCD1 imatinib 0.4965076 0.8160981 0.497 NA NA
G6PD imatinib 0.5046668 0.8160981 0.505 NA NA
TET2 imatinib 0.5098787 0.8160981 0.510 NA NA
DPYD imatinib 0.5204070 0.8160981 0.520 NA NA
EGFR imatinib 0.5206143 0.8160981 0.521 NA NA
GATA1 rucaparib 0.3564121 0.8168175 0.356 NA NA
MPL rucaparib 0.3616444 0.8168175 0.362 NA NA
RUNX1 dasatinib 0.0499298 0.8178090 0.050
NA
CTNNB1 dasatinib 0.0566920 0.8178090 0.057 NA NA
PDGFRB dasatinib 0.0763115 0.8178090 0.076 NA NA
CALR dasatinib 0.0794829 0.8178090 0.079 NA NA
GNAS dasatinib 0.0858809 0.8178090 0.086 NA NA
RPL10 dasatinib 0.0880978 0.8178090 0.088 NA NA
AR dasatinib 0.0930278 0.8178090 0.093 NA NA
BRCA2 dasatinib 0.0931223 0.8178090 0.093 NA NA
NPM1 dasatinib 0.0957018 0.8178090 0.096 NA NA
GNB1 dasatinib 0.1021196 0.8178090 0.102 NA NA
SMC3 dasatinib 0.1047138 0.8178090 0.105 NA NA
AKT3 dasatinib 0.1068213 0.8178090 0.107 NA NA
CREBBP dasatinib 0.1144672 0.8178090 0.114 NA NA
CBLB dasatinib 0.1279141 0.8178090 0.128 NA NA
RIT1 dasatinib 0.1353958 0.8178090 0.135 NA NA
SMC1A dasatinib 0.1356364 0.8178090 0.136 NA NA
WHSC1 dasatinib 0.1428838 0.8178090 0.143 NA NA
CBL dasatinib 0.1464269 0.8178090 0.146 NA NA
XPO1 dasatinib 0.1535899 0.8178090 0.154 NA NA
IKZF1 dasatinib 0.1560706 0.8178090 0.156 NA NA
DNAJB1 dasatinib 0.1772222 0.8178090 0.177 NA NA
WT1 dasatinib 0.1833368 0.8178090 0.183 NA NA
FLT3 dasatinib 0.2059686 0.8178090 0.206 NA NA
SMO dasatinib 0.2145199 0.8178090 0.215 NA NA
JAK3 dasatinib 0.2151836 0.8178090 0.215 NA NA
NOTCH2 dasatinib 0.2206354 0.8178090 0.221 NA NA
DNMT3A dasatinib 0.2260896 0.8178090 0.226 NA NA
FBXW7 dasatinib 0.2361556 0.8178090 0.236 NA NA
NT5C2 dasatinib 0.2417207 0.8178090 0.242 NA NA
ASXL1 dasatinib 0.2501299 0.8178090 0.250 NA NA
EGFR dasatinib 0.2539632 0.8178090 0.254 NA NA
STAT3 dasatinib 0.2617061 0.8178090 0.262 NA NA
GATA2 dasatinib 0.2620633 0.8178090 0.262 NA NA
NOTCH1 dasatinib 0.2625738 0.8178090 0.263 NA NA
PHF6 dasatinib 0.2853231 0.8178090 0.285 NA NA
FGFR3 dasatinib 0.2900699 0.8178090 0.290 NA NA
FANCL dasatinib 0.2913498 0.8178090 0.291 NA NA
ERBB4 dasatinib 0.3011735 0.8178090 0.301 NA NA
ERBB2 dasatinib 0.3121664 0.8178090 0.312 NA NA
VHL dasatinib 0.3136021 0.8178090 0.314 NA NA
CD79B dasatinib 0.3359203 0.8178090 0.336 NA NA
GNAQ dasatinib 0.3359203 0.8178090 0.336 NA NA
PDCD1 dasatinib 0.3359203 0.8178090 0.336 NA NA
DPYD dasatinib 0.3450704 0.8178090 0.345 NA NA
EGF dasatinib 0.3499723 0.8178090 0.350 NA NA
GATA1 dasatinib 0.3512636 0.8178090 0.351 NA NA
PAX5 dasatinib 0.3632617 0.8178090 0.363 NA NA
SF1 dasatinib 0.3774403 0.8178090 0.377 NA NA
PDGFB dasatinib 0.3792939 0.8178090 0.379 NA NA
KRAS dasatinib 0.3806744 0.8178090 0.381 NA NA
BCORL1 dasatinib 0.3812942 0.8178090 0.381 NA NA
PIK3CA dasatinib 0.3837150 0.8178090 0.384 NA NA
BRCA1 dasatinib 0.3928660 0.8178090 0.393 NA NA
ALK dasatinib 0.3952274 0.8178090 0.395 NA NA
FLCN dasatinib 0.4143515 0.8178090 0.414 NA NA
ABL1 dasatinib 0.4250747 0.8178090 0.425 NA NA
UGT1A1 dasatinib 0.4335809 0.8178090 0.434 NA NA
GATA3 dasatinib 0.4405211 0.8178090 0.441 NA NA
RAD21 dasatinib 0.4407374 0.8178090 0.441 NA NA
CYP19A1 dasatinib 0.4547296 0.8178090 0.455 NA NA
CSF3R dasatinib 0.4567258 0.8178090 0.457 NA NA
MPL dasatinib 0.4578876 0.8178090 0.458 NA NA
IDH1 dasatinib 0.4613506 0.8178090 0.461 NA NA
MYCN dasatinib 0.4613506 0.8178090 0.461 NA NA
SF3B1 dasatinib 0.4651305 0.8178090 0.465 NA NA
TP53 dasatinib 0.4684244 0.8178090 0.468 NA NA
PTCH1 dasatinib 0.4723552 0.8178090 0.472 NA NA
SF3B1 erlotinib 0.2824110 0.8179261 0.2824 NA NA
RAD21 erlotinib 0.2906403 0.8179261 0.2906 NA NA
CDKN2A erlotinib 0.2916190 0.8179261 0.2916 NA NA
PIK3CA erlotinib 0.3286540 0.8179261 0.3287 NA NA
WHSC1 erlotinib 0.3322629 0.8179261 0.3323 NA NA
CTCF erlotinib 0.3389875 0.8179261 0.3390 NA NA
SF1 erlotinib 0.3481404 0.8179261 0.3481 NA NA
PDCD1 erlotinib 0.3556069 0.8179261 0.3556 NA NA
IKZF1 erlotinib 0.3582382 0.8179261 0.3582 NA NA
XPO1 erlotinib 0.3661029 0.8179261 0.3661 NA NA
CDK6 erlotinib 0.3864721 0.8179261 0.3865 NA NA
AKT3 erlotinib 0.3944367 0.8179261 0.3944 NA NA
IDH1 erlotinib 0.3944367 0.8179261 0.3944 NA NA
MYCN erlotinib 0.3944367 0.8179261 0.3944 NA NA
U2AF1 erlotinib 0.3944367 0.8179261 0.3944 NA NA
ASXL1 erlotinib 0.3979892 0.8179261 0.3980 NA NA
KIT erlotinib 0.4010455 0.8179261 0.4010 NA NA
BRCA1 erlotinib 0.4046403 0.8179261 0.4046 NA NA
ERBB2 erlotinib 0.4285389 0.8179261 0.4285 NA NA
KMT2A erlotinib 0.4299866 0.8179261 0.4300 NA NA
BTK erlotinib 0.4357267 0.8179261 0.4357 NA NA
CYP19A1 erlotinib 0.4583847 0.8179261 0.4584 NA NA
DNMT3A erlotinib 0.4620527 0.8179261 0.4621 NA NA
TP53 erlotinib 0.4662703 0.8179261 0.4663 NA NA
BRAF erlotinib 0.4662981 0.8179261 0.4663 NA NA
NOTCH1 erlotinib 0.4838940 0.8179261 0.4839 NA NA
CSF3R erlotinib 0.4879427 0.8179261 0.4879 NA NA
KRAS erlotinib 0.4886809 0.8179261 0.4887 NA NA
TSC2 erlotinib 0.4915604 0.8179261 0.4916 NA NA
AR erlotinib 0.4934194 0.8179261 0.4934 NA NA
PHF6 erlotinib 0.4975229 0.8179261 0.4975 NA NA
MAP2K1 erlotinib 0.4978681 0.8179261 0.4979 NA NA
CREBBP tretinoin 0.5236971 0.8202484 0.5237 NA NA
PRPF8 cabozantinib 0.5214349 0.8205825 0.5214 NA NA
CSF3R cabozantinib 0.5261751 0.8205825 0.5262 NA NA
BCOR dasatinib 0.4835917 0.8211459 0.484 NA NA
CDK6 dasatinib 0.5013750 0.8211459 0.501 NA NA
ATM dasatinib 0.5070758 0.8211459 0.507 NA NA
SETD2 dasatinib 0.5131984 0.8211459 0.513 NA NA
MYD88 dasatinib 0.5156798 0.8211459 0.516 NA NA
EZH2 dasatinib 0.5167556 0.8211459 0.517 NA NA
GNB1 lapatinib 0.0188968 0.8231437 0.0189
NA
DPYD lapatinib 0.0212882 0.8231437 0.0213
NA
CBL imatinib 0.5322515 0.8232156 0.532 NA NA
TSC2 imatinib 0.5394738 0.8234074 0.539 NA NA
STAG2 erlotinib 0.5108704 0.8236516 0.5109 NA NA
SMC3 erlotinib 0.5156776 0.8236516 0.5157 NA NA
JAK3 cabozantinib 0.5344359 0.8236600 0.5344 NA NA
AR imatinib 0.5689905 0.8240377 0.569 NA NA
AKT3 imatinib 0.5699859 0.8240377 0.570 NA NA
CDK6 imatinib 0.5699859 0.8240377 0.570 NA NA
FGFR1 imatinib 0.5744946 0.8240377 0.574 NA NA
STAT3 imatinib 0.5754057 0.8240377 0.575 NA NA
MYD88 alectinib 0.4215902 0.8243031 0.4216 NA NA
EGFR temozolomide 0.5669345 0.8252046 0.56693 NA NA
ERBB4 gefitinib 0.1599159 0.8258335 0.1599 NA NA
EGFR gefitinib 0.1651667 0.8258335 0.1652 NA NA
SMC1A alectinib 0.4329711 0.8276602 0.4330 NA NA
ZRSR2 alectinib 0.4359432 0.8276602 0.4359 NA NA
ERBB2 alectinib 0.4455420 0.8277525 0.4455 NA NA
PDGFB alectinib 0.4572960 0.8277525 0.4573 NA NA
TET2 alectinib 0.4641646 0.8277525 0.4642 NA NA
XPO1 alectinib 0.4657556 0.8277525 0.4658 NA NA
GATA2 alectinib 0.4737183 0.8277525 0.4737 NA NA
CDK6 alectinib 0.4739041 0.8277525 0.4739 NA NA
AKT1 cabozantinib 0.5467795 0.8282849 0.5468 NA NA
STAT3 cabozantinib 0.5530778 0.8282849 0.5531 NA NA
GATA3 cabozantinib 0.5564051 0.8282849 0.5564 NA NA
NT5C2 docetaxel 0.4447563 0.8291024 0.44476 NA NA
SRSF2 docetaxel 0.4573914 0.8291024 0.45739 NA NA
BTK docetaxel 0.4588269 0.8291024 0.45883 NA NA
MAP2K2 docetaxel 0.4671915 0.8291024 0.46719 NA NA
CD79B docetaxel 0.4739139 0.8291024 0.47391 NA NA
CYP19A1 docetaxel 0.4847190 0.8291024 0.48472 NA NA
RIT1 docetaxel 0.4934091 0.8291024 0.49341 NA NA
SSX1 docetaxel 0.4946266 0.8291024 0.49463 NA NA
KMT2A docetaxel 0.4952628 0.8291024 0.49526 NA NA
CSF3R docetaxel 0.4974614 0.8291024 0.49746 NA NA
G6PD erlotinib 0.5348254 0.8301554 0.5348 NA NA
JAK3 erlotinib 0.5363347 0.8301554 0.5363 NA NA
MYD88 erlotinib 0.5580136 0.8301554 0.5580 NA NA
BCOR erlotinib 0.5633547 0.8301554 0.5634 NA NA
TSC1 erlotinib 0.5633547 0.8301554 0.5634 NA NA
EGF erlotinib 0.5636517 0.8301554 0.5637 NA NA
JAK2 erlotinib 0.5702807 0.8301554 0.5703 NA NA
CBLB temozolomide 0.5787407 0.8331322 0.57874 NA NA
PDGFRA temozolomide 0.5883211 0.8339970 0.58832 NA NA
PTEN temozolomide 0.5920742 0.8339970 0.59207 NA NA
ASXL1 docetaxel 0.5112416 0.8340082 0.51124 NA NA
DPYD docetaxel 0.5183010 0.8340082 0.51830 NA NA
MET docetaxel 0.5196512 0.8340082 0.51965 NA NA
RET nilotinib 0.5840052 0.8362659 0.5840 NA NA
MGMT nilotinib 0.5978288 0.8362659 0.5978 NA NA
SMC1A nilotinib 0.5984846 0.8362659 0.5985 NA NA
CEBPA nilotinib 0.6007708 0.8362659 0.6008 NA NA
SMC3 nilotinib 0.6046846 0.8362659 0.6047 NA NA
SRSF2 rucaparib 0.3768031 0.8366305 0.377 NA NA
CBL docetaxel 0.5357729 0.8390025 0.53577 NA NA
TET2 docetaxel 0.5434908 0.8390025 0.54349 NA NA
SETBP1 docetaxel 0.5442333 0.8390025 0.54423 NA NA
WT1 docetaxel 0.5485785 0.8390025 0.54858 NA NA
TSC2 cabozantinib 0.5710996 0.8406072 0.5711 NA NA
CDK4 dasatinib 0.5363244 0.8407248 0.536 NA NA
STAT3 temozolomide 0.6037625 0.8414137 0.60376 NA NA
CDK4 temozolomide 0.6106364 0.8420355 0.61064 NA NA
CTCF trametinib 0.4472654 0.8426740 0.44727 NA NA
ALK cabozantinib 0.5795396 0.8435521 0.5795 NA NA
TSC2 dasatinib 0.5568736 0.8462853 0.557 NA NA
PIGA dasatinib 0.5637000 0.8462853 0.564 NA NA
PRPF40B dasatinib 0.5822601 0.8462853 0.582 NA NA
TET2 dasatinib 0.5882617 0.8462853 0.588 NA NA
CRLF2 dasatinib 0.5887259 0.8462853 0.589 NA NA
KMT2A dasatinib 0.5908858 0.8462853 0.591 NA NA
FGFR1 dasatinib 0.5933885 0.8462853 0.593 NA NA
CXCR4 dasatinib 0.5982362 0.8462853 0.598 NA NA
HRAS trametinib 0.4570029 0.8470273 0.45700 NA NA
MGMT trametinib 0.4735520 0.8470273 0.47355 NA NA
SETD2 trametinib 0.4755931 0.8470273 0.47559 NA NA
PTCH1 trametinib 0.4756384 0.8470273 0.47564 NA NA
SMC3 lapatinib 0.0337864 0.8483482 0.0338
NA
PAX8 lapatinib 0.0512666 0.8483482 0.0513 NA NA
EZH2 lapatinib 0.0555983 0.8483482 0.0556 NA NA
NCOA2 lapatinib 0.0614925 0.8483482 0.0615 NA NA
BRCA2 lapatinib 0.0716745 0.8483482 0.0717 NA NA
RPL10 lapatinib 0.0958239 0.8483482 0.0958 NA NA
MET lapatinib 0.0972319 0.8483482 0.0972 NA NA
FLCN lapatinib 0.0985096 0.8483482 0.0985 NA NA
RUNX1 lapatinib 0.1014759 0.8483482 0.1015 NA NA
CBL lapatinib 0.1099732 0.8483482 0.1100 NA NA
CRLF2 lapatinib 0.1138543 0.8483482 0.1139 NA NA
NRAS lapatinib 0.1166057 0.8483482 0.1166 NA NA
ERBB2 lapatinib 0.1230985 0.8483482 0.1231 NA NA
GATA3 lapatinib 0.1247292 0.8483482 0.1247 NA NA
UGT1A1 lapatinib 0.1409522 0.8483482 0.1410 NA NA
ALK lapatinib 0.1428928 0.8483482 0.1429 NA NA
NOTCH1 lapatinib 0.1462669 0.8483482 0.1463 NA NA
CDK6 tretinoin 0.5504161 0.8488081 0.5504 NA NA
CYP19A1 tretinoin 0.5549899 0.8488081 0.5550 NA NA
MPL gefitinib 0.1763514 0.8490991 0.1764 NA NA
PTCH1 palbociclib 0.3180803 0.8503779 0.3181 NA NA
NRAS dasatinib 0.6085294 0.8504748 0.609 NA NA
WT1 imatinib 0.6012342 0.8505264 0.601 NA NA
SF1 tretinoin 0.5723561 0.8505951 0.5724 NA NA
STAG2 tretinoin 0.5772249 0.8505951 0.5772 NA NA
GNA11 tretinoin 0.5858785 0.8505951 0.5859 NA NA
EGFR tretinoin 0.5940328 0.8505951 0.5940 NA NA
U2AF1 tretinoin 0.6080591 0.8505951 0.6081 NA NA
DNAJB1 tretinoin 0.6098927 0.8505951 0.6099 NA NA
DDIT3 tretinoin 0.6226906 0.8505951 0.6227 NA NA
DNMT3A tretinoin 0.6240726 0.8505951 0.6241 NA NA
EGF tretinoin 0.6298346 0.8505951 0.6298 NA NA
IDH1 tretinoin 0.6327016 0.8505951 0.6327 NA NA
BCOR tretinoin 0.6346058 0.8505951 0.6346 NA NA
PAX5 tretinoin 0.6346748 0.8505951 0.6347 NA NA
CDK4 cabozantinib 0.5910559 0.8508607 0.5911 NA NA
MPL afatinib 0.3387786 0.8510648 0.3388 NA NA
KIT afatinib 0.3580267 0.8510648 0.3580 NA NA
SETBP1 afatinib 0.3588256 0.8510648 0.3588 NA NA
CXCR4 afatinib 0.3626374 0.8510648 0.3626 NA NA
FANCL afatinib 0.3712677 0.8510648 0.3713 NA NA
SF1 afatinib 0.3735649 0.8510648 0.3736 NA NA
ASXL1 afatinib 0.3758930 0.8510648 0.3759 NA NA
SMO afatinib 0.3813865 0.8510648 0.3814 NA NA
ATM afatinib 0.3862525 0.8510648 0.3863 NA NA
MDM2 nilotinib 0.6317840 0.8529826 0.6318 NA NA
FBXW7 nilotinib 0.6329663 0.8529826 0.6330 NA NA
PAX8 nilotinib 0.6400247 0.8529826 0.6400 NA NA
FGFR1 nilotinib 0.6591234 0.8529826 0.6591 NA NA
CREBBP nilotinib 0.6672208 0.8529826 0.6672 NA NA
BRCA2 nilotinib 0.6739857 0.8529826 0.6740 NA NA
CDKN2A nilotinib 0.6769401 0.8529826 0.6769 NA NA
CRLF2 nilotinib 0.6773888 0.8529826 0.6774 NA NA
PAX5 nilotinib 0.6809647 0.8529826 0.6810 NA NA
CBLB nilotinib 0.6856568 0.8529826 0.6857 NA NA
ERBB4 nilotinib 0.6889474 0.8529826 0.6889 NA NA
SMC1A gefitinib 0.1838148 0.8534259 0.1838 NA NA
BCORL1 palbociclib 0.3287607 0.8547330 0.3288 NA NA
PDGFB palbociclib 0.3327587 0.8547330 0.3328 NA NA
CYP19A1 cabozantinib 0.6024929 0.8576230 0.6025 NA NA
CD79B cabozantinib 0.6190926 0.8576230 0.6191 NA NA
MYCN cabozantinib 0.6193520 0.8576230 0.6194 NA NA
EED cabozantinib 0.6219404 0.8576230 0.6219 NA NA
SH2B3 midostaurin 0.3733494 0.8580485 0.3733 NA NA
CDK4 dabrafenib 0.3540843 0.8589824 0.35408 NA NA
STAG2 midostaurin 0.3813979 0.8590892 0.3814 NA NA
AR midostaurin 0.3869180 0.8590892 0.3869 NA NA
ABL1 erlotinib 0.5985108 0.8603592 0.5985 NA NA
PIK3CA temozolomide 0.6319837 0.8623944 0.63198 NA NA
FANCL crizotinib 0.2386699 0.8641806 0.2387 NA NA
MPL crizotinib 0.2519796 0.8641806 0.2520 NA NA
UGT1A1 crizotinib 0.2625570 0.8641806 0.2626 NA NA
DNAJB1 crizotinib 0.2676694 0.8641806 0.2677 NA NA
AR crizotinib 0.2791398 0.8641806 0.2791 NA NA
RIT1 crizotinib 0.3182654 0.8641806 0.3183 NA NA
SMC1A crizotinib 0.3195953 0.8641806 0.3196 NA NA
NOTCH2 crizotinib 0.3297967 0.8641806 0.3298 NA NA
PRPF8 crizotinib 0.3336126 0.8641806 0.3336 NA NA
AKT2 crizotinib 0.3358098 0.8641806 0.3358 NA NA
NT5C2 crizotinib 0.3358098 0.8641806 0.3358 NA NA
NRAS crizotinib 0.3513508 0.8641806 0.3514 NA NA
PIGA crizotinib 0.3571747 0.8641806 0.3572 NA NA
STAG2 crizotinib 0.3627363 0.8641806 0.3627 NA NA
IKZF1 crizotinib 0.3663689 0.8641806 0.3664 NA NA
PTEN crizotinib 0.3676751 0.8641806 0.3677 NA NA
ALK crizotinib 0.3700920 0.8641806 0.3701 NA NA
NPM1 crizotinib 0.3719543 0.8641806 0.3720 NA NA
FGFR2 crizotinib 0.3724916 0.8641806 0.3725 NA NA
TSC1 docetaxel 0.5725527 0.8654867 0.57255 NA NA
RIT1 cabozantinib 0.6344014 0.8656936 0.6344 NA NA
STAG2 afatinib 0.3995949 0.8657890 0.3996 NA NA
PTEN erlotinib 0.6294097 0.8671968 0.6294 NA NA
SMO erlotinib 0.6333592 0.8671968 0.6334 NA NA
PML erlotinib 0.6360548 0.8671968 0.6361 NA NA
IDH2 erlotinib 0.6634451 0.8671968 0.6634 NA NA
CTNNB1 erlotinib 0.6709344 0.8671968 0.6709 NA NA
PDGFRA erlotinib 0.6824019 0.8671968 0.6824 NA NA
CD79B erlotinib 0.6861034 0.8671968 0.6861 NA NA
DNAJB1 erlotinib 0.6861034 0.8671968 0.6861 NA NA
GNAQ erlotinib 0.6861034 0.8671968 0.6861 NA NA
MPL erlotinib 0.6862166 0.8671968 0.6862 NA NA
NOTCH2 erlotinib 0.6862166 0.8671968 0.6862 NA NA
ASXL1 ruxolitinib 0.3708094 0.8674292 0.3708 NA NA
JAK2 gefitinib 0.1997501 0.8676691 0.1998 NA NA
ESR1 gefitinib 0.2002313 0.8676691 0.2002 NA NA
MAP2K2 dabrafenib 0.3682429 0.8678565 0.36824 NA NA
NCOA2 dabrafenib 0.3782220 0.8678565 0.37822 NA NA
WT1 dabrafenib 0.3899972 0.8678565 0.39000 NA NA
CTCF dabrafenib 0.3923327 0.8678565 0.39233 NA NA
JAK3 dabrafenib 0.4085791 0.8678565 0.40858 NA NA
FGFR3 dabrafenib 0.4155330 0.8678565 0.41553 NA NA
MPL dabrafenib 0.4381599 0.8678565 0.43816 NA NA
STAG2 dabrafenib 0.4388822 0.8678565 0.43888 NA NA
ABL1 dabrafenib 0.4415642 0.8678565 0.44156 NA NA
IKZF1 dabrafenib 0.4423625 0.8678565 0.44236 NA NA
ASXL1 dabrafenib 0.4430462 0.8678565 0.44305 NA NA
AKT1 dabrafenib 0.4490980 0.8678565 0.44910 NA NA
PDGFRA dabrafenib 0.4498286 0.8678565 0.44983 NA NA
ETV6 dabrafenib 0.4562090 0.8678565 0.45621 NA NA
CDKN2A dabrafenib 0.4571153 0.8678565 0.45712 NA NA
CEBPA temozolomide 0.6502677 0.8687880 0.65027 NA NA
MGMT temozolomide 0.6634570 0.8687880 0.66346 NA NA
DDIT3 temozolomide 0.6680811 0.8687880 0.66808 NA NA
GATA2 temozolomide 0.6681305 0.8687880 0.66813 NA NA
ROS1 temozolomide 0.6751390 0.8687880 0.67514 NA NA
SH2B3 temozolomide 0.6764609 0.8687880 0.67646 NA NA
ERBB2 ruxolitinib 0.3785733 0.8688783 0.3786 NA NA
CXCR4 ruxolitinib 0.3846942 0.8688783 0.3847 NA NA
PTEN trametinib 0.4995948 0.8688946 0.49959 NA NA
GATA1 trametinib 0.5114237 0.8688946 0.51142 NA NA
FANCL trametinib 0.5123217 0.8688946 0.51232 NA NA
CDK4 trametinib 0.5235152 0.8688946 0.52352 NA NA
KMT2A trametinib 0.5242068 0.8688946 0.52421 NA NA
PDGFB trametinib 0.5280206 0.8688946 0.52802 NA NA
PDGFRA docetaxel 0.5828922 0.8709883 0.58289 NA NA
CDK6 gefitinib 0.2081255 0.8727844 0.2081 NA NA
SMC3 palbociclib 0.3538314 0.8731789 0.3538 NA NA
TSC1 palbociclib 0.3704875 0.8731789 0.3705 NA NA
SMO palbociclib 0.3726724 0.8731789 0.3727 NA NA
G6PD palbociclib 0.3728013 0.8731789 0.3728 NA NA
AKT1 palbociclib 0.3961746 0.8731789 0.3962 NA NA
NPM1 palbociclib 0.3996308 0.8731789 0.3996 NA NA
WT1 palbociclib 0.4072870 0.8731789 0.4073 NA NA
PDGFRA palbociclib 0.4083491 0.8731789 0.4083 NA NA
PTPN11 palbociclib 0.4211924 0.8731789 0.4212 NA NA
GNB1 palbociclib 0.4395108 0.8731789 0.4395 NA NA
GNAS palbociclib 0.4431247 0.8731789 0.4431 NA NA
IDH1 palbociclib 0.4458469 0.8731789 0.4458 NA NA
GNA11 palbociclib 0.4475585 0.8731789 0.4476 NA NA
SF1 palbociclib 0.4523993 0.8731789 0.4524 NA NA
CSF3R palbociclib 0.4595627 0.8731789 0.4596 NA NA
ERBB3 palbociclib 0.4724268 0.8731789 0.4724 NA NA
SF3B1 palbociclib 0.4773083 0.8731789 0.4773 NA NA
CTNNB1 palbociclib 0.4793518 0.8731789 0.4794 NA NA
WHSC1 palbociclib 0.4845512 0.8731789 0.4846 NA NA
JAK3 palbociclib 0.4969978 0.8731789 0.4970 NA NA
PIK3CA palbociclib 0.5003636 0.8731789 0.5004 NA NA
KIT palbociclib 0.5134101 0.8731789 0.5134 NA NA
EML4 palbociclib 0.5149978 0.8731789 0.5150 NA NA
CD79B palbociclib 0.5185060 0.8731789 0.5185 NA NA
DNMT3A palbociclib 0.5222786 0.8731789 0.5223 NA NA
ASXL1 palbociclib 0.5246346 0.8731789 0.5246 NA NA
RUNX1 palbociclib 0.5310874 0.8731789 0.5311 NA NA
CXCR4 palbociclib 0.5381348 0.8731789 0.5381 NA NA
PIGA palbociclib 0.5433316 0.8731789 0.5433 NA NA
MPL palbociclib 0.5554405 0.8731789 0.5554 NA NA
PAX8 palbociclib 0.5648846 0.8731789 0.5649 NA NA
JAK2 palbociclib 0.5675682 0.8731789 0.5676 NA NA
FGFR3 palbociclib 0.5685115 0.8731789 0.5685 NA NA
CDC73 palbociclib 0.5776497 0.8731789 0.5776 NA NA
AKT3 palbociclib 0.5783610 0.8731789 0.5784 NA NA
CDK6 palbociclib 0.5875801 0.8731789 0.5876 NA NA
DNAJB1 palbociclib 0.5878256 0.8731789 0.5878 NA NA
NOTCH1 palbociclib 0.5985739 0.8731789 0.5986 NA NA
CBL palbociclib 0.6031882 0.8731789 0.6032 NA NA
XPO1 palbociclib 0.6065594 0.8731789 0.6066 NA NA
MET temozolomide 0.6917583 0.8740358 0.69176 NA NA
ABL1 temozolomide 0.6987934 0.8740358 0.69879 NA NA
CRLF2 temozolomide 0.7018756 0.8740358 0.70188 NA NA
KRAS temozolomide 0.7150718 0.8740358 0.71507 NA NA
NRAS temozolomide 0.7197845 0.8740358 0.71978 NA NA
HRAS temozolomide 0.7205791 0.8740358 0.72058 NA NA
DPYD alectinib 0.5225472 0.8743299 0.5225 NA NA
PHF6 alectinib 0.5336040 0.8743299 0.5336 NA NA
AR alectinib 0.5352746 0.8743299 0.5353 NA NA
ETV6 alectinib 0.5387069 0.8743299 0.5387 NA NA
MPL alectinib 0.5402344 0.8743299 0.5402 NA NA
PAX5 alectinib 0.5518586 0.8743299 0.5519 NA NA
ERBB3 alectinib 0.5530430 0.8743299 0.5530 NA NA
ATM alectinib 0.5548611 0.8743299 0.5549 NA NA
MAP2K2 alectinib 0.5608883 0.8743299 0.5609 NA NA
U2AF1 alectinib 0.5756944 0.8743299 0.5757 NA NA
GNA11 alectinib 0.5790606 0.8743299 0.5791 NA NA
DNAJB1 alectinib 0.5806618 0.8743299 0.5807 NA NA
SMO lapatinib 0.1785842 0.8745041 0.1786 NA NA
SF3B1 lapatinib 0.1846865 0.8745041 0.1847 NA NA
CXCR4 lapatinib 0.1971848 0.8745041 0.1972 NA NA
AR lapatinib 0.2135960 0.8745041 0.2136 NA NA
DNAJB1 lapatinib 0.2180070 0.8745041 0.2180 NA NA
SMC1A lapatinib 0.2210226 0.8745041 0.2210 NA NA
CDK4 lapatinib 0.2244316 0.8745041 0.2244 NA NA
TET2 lapatinib 0.2251236 0.8745041 0.2251 NA NA
RIT1 lapatinib 0.2253423 0.8745041 0.2253 NA NA
ABL1 lapatinib 0.2342922 0.8745041 0.2343 NA NA
CALR lapatinib 0.2514271 0.8745041 0.2514 NA NA
MGMT lapatinib 0.2514271 0.8745041 0.2514 NA NA
PDGFB lapatinib 0.2633229 0.8745041 0.2633 NA NA
NPM1 lapatinib 0.2737483 0.8745041 0.2737 NA NA
ERBB4 lapatinib 0.2819297 0.8745041 0.2819 NA NA
BCORL1 lapatinib 0.2829109 0.8745041 0.2829 NA NA
CD79B lapatinib 0.2864755 0.8745041 0.2865 NA NA
GNAQ lapatinib 0.2864755 0.8745041 0.2865 NA NA
DNMT3A ruxolitinib 0.4082055 0.8746635 0.4082 NA NA
SMO ruxolitinib 0.4108655 0.8746635 0.4109 NA NA
NOTCH2 ruxolitinib 0.4112888 0.8746635 0.4113 NA NA
SRSF2 ruxolitinib 0.4243256 0.8746635 0.4243 NA NA
GATA1 ruxolitinib 0.4461233 0.8746635 0.4461 NA NA
EGF ruxolitinib 0.4493943 0.8746635 0.4494 NA NA
BCOR ruxolitinib 0.4496662 0.8746635 0.4497 NA NA
SF1 ruxolitinib 0.4512242 0.8746635 0.4512 NA NA
DDIT3 ruxolitinib 0.4573678 0.8746635 0.4574 NA NA
CREBBP ruxolitinib 0.4719661 0.8746635 0.4720 NA NA
PDGFRB ruxolitinib 0.4765472 0.8746635 0.4765 NA NA
FANCL ruxolitinib 0.4784767 0.8746635 0.4785 NA NA
BRCA1 ruxolitinib 0.4788739 0.8746635 0.4789 NA NA
NPM1 ruxolitinib 0.4817234 0.8746635 0.4817 NA NA
KMT2A ruxolitinib 0.5043906 0.8746635 0.5044 NA NA
CBL ruxolitinib 0.5128995 0.8746635 0.5129 NA NA
DPYD ruxolitinib 0.5165164 0.8746635 0.5165 NA NA
GNA11 ruxolitinib 0.5187155 0.8746635 0.5187 NA NA
ETV6 ruxolitinib 0.5373343 0.8746635 0.5373 NA NA
IDH1 ruxolitinib 0.5528888 0.8746635 0.5529 NA NA
RET ruxolitinib 0.5597886 0.8746635 0.5598 NA NA
MDM2 ruxolitinib 0.5647650 0.8746635 0.5648 NA NA
BTK ruxolitinib 0.5677799 0.8746635 0.5678 NA NA
CDC73 ruxolitinib 0.5718819 0.8746635 0.5719 NA NA
TSC2 ruxolitinib 0.5824296 0.8746635 0.5824 NA NA
PTCH1 ruxolitinib 0.5835921 0.8746635 0.5836 NA NA
ESR1 ruxolitinib 0.5973766 0.8746635 0.5974 NA NA
HRAS ruxolitinib 0.5989160 0.8746635 0.5989 NA NA
GATA3 ruxolitinib 0.6067286 0.8746635 0.6067 NA NA
AKT3 ruxolitinib 0.6086854 0.8746635 0.6087 NA NA
SH2B3 ruxolitinib 0.6086854 0.8746635 0.6087 NA NA
GNAS ruxolitinib 0.6157098 0.8746635 0.6157 NA NA
NOTCH1 ruxolitinib 0.6220714 0.8746635 0.6221 NA NA
CSF3R ruxolitinib 0.6235370 0.8746635 0.6235 NA NA
PIGA ruxolitinib 0.6341800 0.8746635 0.6342 NA NA
GNAQ ruxolitinib 0.6391925 0.8746635 0.6392 NA NA
FGFR3 ruxolitinib 0.6425963 0.8746635 0.6426 NA NA
EGFR ruxolitinib 0.6447588 0.8746635 0.6448 NA NA
ERBB3 ruxolitinib 0.6532068 0.8746635 0.6532 NA NA
CTLA4 ruxolitinib 0.6543284 0.8746635 0.6543 NA NA
GATA3 tretinoin 0.6613899 0.8754881 0.6614 NA NA
ASXL1 tretinoin 0.6667178 0.8754881 0.6667 NA NA
MYCN trametinib 0.5389272 0.8757567 0.53893 NA NA
CTCF midostaurin 0.4387679 0.8766624 0.4388 NA NA
CYP19A1 midostaurin 0.4400719 0.8766624 0.4401 NA NA
TP53 midostaurin 0.4402169 0.8766624 0.4402 NA NA
JAK3 midostaurin 0.4827637 0.8766624 0.4828 NA NA
GNAQ midostaurin 0.4871146 0.8766624 0.4871 NA NA
ALK midostaurin 0.4971993 0.8766624 0.4972 NA NA
DDIT3 midostaurin 0.5062536 0.8766624 0.5063 NA NA
NOTCH2 midostaurin 0.5068663 0.8766624 0.5069 NA NA
SSX1 midostaurin 0.5081623 0.8766624 0.5082 NA NA
DPYD midostaurin 0.5086465 0.8766624 0.5086 NA NA
CBLB midostaurin 0.5224343 0.8766624 0.5224 NA NA
NRAS midostaurin 0.5263903 0.8766624 0.5264 NA NA
MYD88 midostaurin 0.5310291 0.8766624 0.5310 NA NA
DNMT3A midostaurin 0.5328652 0.8766624 0.5329 NA NA
SMO midostaurin 0.5343564 0.8766624 0.5344 NA NA
ABL1 midostaurin 0.5402282 0.8766624 0.5402 NA NA
STAT3 midostaurin 0.5403698 0.8766624 0.5404 NA NA
CXCR4 midostaurin 0.5422466 0.8766624 0.5422 NA NA
TSC2 midostaurin 0.5433441 0.8766624 0.5433 NA NA
CBL midostaurin 0.5442339 0.8766624 0.5442 NA NA
FLCN midostaurin 0.5460539 0.8766624 0.5461 NA NA
PDGFB midostaurin 0.5477164 0.8766624 0.5477 NA NA
KIT midostaurin 0.5523909 0.8766624 0.5524 NA NA
AKT2 midostaurin 0.5554426 0.8766624 0.5554 NA NA
SF3B1 imatinib 0.6360653 0.8767987 0.636 NA NA
CREBBP imatinib 0.6365514 0.8767987 0.637 NA NA
KRAS imatinib 0.6424818 0.8767987 0.642 NA NA
PDGFRA rucaparib 0.4016231 0.8768771 0.402 NA NA
AKT2 gefitinib 0.2158478 0.8768818 0.2158 NA NA
CEBPA afatinib 0.4120008 0.8780345 0.4120 NA NA
BRAF temozolomide 0.7335771 0.8785321 0.73358 NA NA
CYP19A1 temozolomide 0.7376987 0.8785321 0.73770 NA NA
WT1 gefitinib 0.2363973 0.8796561 0.2364 NA NA
PHF6 gefitinib 0.2574329 0.8796561 0.2574 NA NA
CDKN2A gefitinib 0.2634206 0.8796561 0.2634 NA NA
MAP2K2 gefitinib 0.2745244 0.8796561 0.2745 NA NA
CBL gefitinib 0.2788384 0.8796561 0.2788 NA NA
FGFR1 gefitinib 0.2872103 0.8796561 0.2872 NA NA
RIT1 gefitinib 0.3002316 0.8796561 0.3002 NA NA
TPMT gefitinib 0.3116629 0.8796561 0.3117 NA NA
IDH2 gefitinib 0.3258316 0.8796561 0.3258 NA NA
FLT3 gefitinib 0.3274937 0.8796561 0.3275 NA NA
ERBB3 gefitinib 0.3353927 0.8796561 0.3354 NA NA
SETBP1 gefitinib 0.3370540 0.8796561 0.3371 NA NA
CDK4 gefitinib 0.3394024 0.8796561 0.3394 NA NA
PRPF8 gefitinib 0.3503421 0.8796561 0.3503 NA NA
TET2 gefitinib 0.3552137 0.8796561 0.3552 NA NA
PDGFB gefitinib 0.3627861 0.8796561 0.3628 NA NA
SSX1 gefitinib 0.3647486 0.8796561 0.3647 NA NA
GNA11 gefitinib 0.3799164 0.8796561 0.3799 NA NA
BRCA2 gefitinib 0.3852457 0.8796561 0.3852 NA NA
BTK gefitinib 0.3953704 0.8796561 0.3954 NA NA
DNAJB1 gefitinib 0.3961625 0.8796561 0.3962 NA NA
MET gefitinib 0.3977576 0.8796561 0.3978 NA NA
JAK3 gefitinib 0.3982969 0.8796561 0.3983 NA NA
EZH2 gefitinib 0.4053278 0.8796561 0.4053 NA NA
ASXL1 gefitinib 0.4134771 0.8796561 0.4135 NA NA
BCOR gefitinib 0.4214414 0.8796561 0.4214 NA NA
BCORL1 gefitinib 0.4232724 0.8796561 0.4233 NA NA
AR gefitinib 0.4279563 0.8796561 0.4280 NA NA
KIT gefitinib 0.4300536 0.8796561 0.4301 NA NA
FLCN gefitinib 0.4366833 0.8796561 0.4367 NA NA
IKZF1 gefitinib 0.4416698 0.8796561 0.4417 NA NA
STAG2 gefitinib 0.4492901 0.8796561 0.4493 NA NA
PAX8 gefitinib 0.4607206 0.8796561 0.4607 NA NA
IDH1 gefitinib 0.4721833 0.8796561 0.4722 NA NA
PRPF40B gefitinib 0.4831030 0.8796561 0.4831 NA NA
CDC73 gefitinib 0.4859099 0.8796561 0.4859 NA NA
STAT3 gefitinib 0.4879455 0.8796561 0.4879 NA NA
RAD21 gefitinib 0.5067814 0.8796561 0.5068 NA NA
PAX5 gefitinib 0.5085301 0.8796561 0.5085 NA NA
BRAF gefitinib 0.5109860 0.8796561 0.5110 NA NA
DPYD gefitinib 0.5210093 0.8796561 0.5210 NA NA
NPM1 gefitinib 0.5227495 0.8796561 0.5227 NA NA
MDM2 gefitinib 0.5257801 0.8796561 0.5258 NA NA
SF1 gefitinib 0.5385821 0.8796561 0.5386 NA NA
CTLA4 gefitinib 0.5404583 0.8796561 0.5405 NA NA
GNB1 gefitinib 0.5488952 0.8796561 0.5489 NA NA
ROS1 gefitinib 0.5511895 0.8796561 0.5512 NA NA
MYCN gefitinib 0.5550598 0.8796561 0.5551 NA NA
CD79B gefitinib 0.5587538 0.8796561 0.5588 NA NA
CEBPA gefitinib 0.5601244 0.8796561 0.5601 NA NA
RET gefitinib 0.5658382 0.8796561 0.5658 NA NA
CYP19A1 gefitinib 0.5683932 0.8796561 0.5684 NA NA
NT5C2 ruxolitinib 0.6648061 0.8796929 0.6648 NA NA
MET ruxolitinib 0.6724758 0.8809433 0.6725 NA NA
CSF3R crizotinib 0.3873438 0.8810173 0.3873 NA NA
ESR1 tretinoin 0.6845216 0.8821557 0.6845 NA NA
FBXW7 tretinoin 0.6863672 0.8821557 0.6864 NA NA
GNB1 tretinoin 0.7042251 0.8821557 0.7042 NA NA
CTNNB1 tretinoin 0.7063175 0.8821557 0.7063 NA NA
CBL tretinoin 0.7065815 0.8821557 0.7066 NA NA
PAX8 tretinoin 0.7192167 0.8821557 0.7192 NA NA
CBLB tretinoin 0.7276859 0.8821557 0.7277 NA NA
CDK4 tretinoin 0.7381800 0.8821557 0.7382 NA NA
SETBP1 tretinoin 0.7395737 0.8821557 0.7396 NA NA
PIGA tretinoin 0.7420835 0.8821557 0.7421 NA NA
SETD2 tretinoin 0.7482992 0.8821557 0.7483 NA NA
ERBB4 tretinoin 0.7532253 0.8821557 0.7532 NA NA
NOTCH1 alectinib 0.5992984 0.8822458 0.5993 NA NA
IKZF1 alectinib 0.5993884 0.8822458 0.5994 NA NA
NCOA2 midostaurin 0.5663758 0.8832766 0.5664 NA NA
ESR1 dasatinib 0.6806688 0.8852220 0.681 NA NA
U2AF1 dasatinib 0.6894250 0.8852220 0.689 NA NA
NCOA2 dasatinib 0.6940632 0.8852220 0.694 NA NA
PML dasatinib 0.7028188 0.8852220 0.703 NA NA
TSC1 dasatinib 0.7033301 0.8852220 0.703 NA NA
IDH2 dasatinib 0.7090830 0.8852220 0.709 NA NA
JAK2 dasatinib 0.7103203 0.8852220 0.710 NA NA
SETBP1 dasatinib 0.7145822 0.8852220 0.715 NA NA
RET dasatinib 0.7148163 0.8852220 0.715 NA NA
BTK dasatinib 0.7173351 0.8852220 0.717 NA NA
PAX8 dasatinib 0.7173351 0.8852220 0.717 NA NA
EGF alectinib 0.6088652 0.8855398 0.6089 NA NA
FGFR2 alectinib 0.6211625 0.8855398 0.6212 NA NA
FBXW7 alectinib 0.6219058 0.8855398 0.6219 NA NA
ALK erlotinib 0.7099827 0.8859576 0.7100 NA NA
ERBB3 erlotinib 0.7203169 0.8859576 0.7203 NA NA
NT5C2 erlotinib 0.7318780 0.8859576 0.7319 NA NA
RUNX1 erlotinib 0.7318780 0.8859576 0.7319 NA NA
CBLB lapatinib 0.3188445 0.8877410 0.3188 NA NA
FBXW7 lapatinib 0.3216173 0.8877410 0.3216 NA NA
FGFR3 lapatinib 0.3229794 0.8877410 0.3230 NA NA
PAX5 lapatinib 0.3307420 0.8877410 0.3307 NA NA
TSC2 lapatinib 0.3311360 0.8877410 0.3311 NA NA
AKT3 lapatinib 0.3649345 0.8877410 0.3649 NA NA
IDH1 lapatinib 0.3649345 0.8877410 0.3649 NA NA
MYCN lapatinib 0.3649345 0.8877410 0.3649 NA NA
PDGFRB lapatinib 0.3673411 0.8877410 0.3673 NA NA
TSC1 lapatinib 0.3673411 0.8877410 0.3673 NA NA
TSC1 sunitinib 0.0300384 0.8879684 0.030
NA
SF3B1 sunitinib 0.0358665 0.8879684 0.036
NA
CREBBP sunitinib 0.0413703 0.8879684 0.041
NA
CDK6 sunitinib 0.0453261 0.8879684 0.045
NA
DNMT3A sunitinib 0.0480660 0.8879684 0.048
NA
RET sunitinib 0.0511239 0.8879684 0.051 NA NA
KMT2A sunitinib 0.0567409 0.8879684 0.057 NA NA
STAG2 sunitinib 0.0614276 0.8879684 0.061 NA NA
RPL10 sunitinib 0.0880602 0.8879684 0.088 NA NA
WT1 sunitinib 0.0903271 0.8879684 0.090 NA NA
PAX5 sunitinib 0.1124728 0.8879684 0.112 NA NA
FLCN sunitinib 0.1281801 0.8879684 0.128 NA NA
CBL sunitinib 0.1283819 0.8879684 0.128 NA NA
CDK4 sunitinib 0.1393853 0.8879684 0.139 NA NA
DNAJB1 sunitinib 0.1441839 0.8879684 0.144 NA NA
RUNX1 sunitinib 0.1467646 0.8879684 0.147 NA NA
RIT1 sunitinib 0.1606843 0.8879684 0.161 NA NA
SMC1A sunitinib 0.1610595 0.8879684 0.161 NA NA
GATA2 sunitinib 0.1728009 0.8879684 0.173 NA NA
SETBP1 sunitinib 0.1847349 0.8879684 0.185 NA NA
ALK sunitinib 0.1882759 0.8879684 0.188 NA NA
TSC2 sunitinib 0.1886391 0.8879684 0.189 NA NA
NT5C2 sunitinib 0.2060779 0.8879684 0.206 NA NA
PTEN sunitinib 0.2301212 0.8879684 0.230 NA NA
ATM sunitinib 0.2338151 0.8879684 0.234 NA NA
GATA3 sunitinib 0.2349335 0.8879684 0.235 NA NA
GNAS sunitinib 0.2380488 0.8879684 0.238 NA NA
PML sunitinib 0.2560406 0.8879684 0.256 NA NA
STAT3 sunitinib 0.2711355 0.8879684 0.271 NA NA
CXCR4 sunitinib 0.2869137 0.8879684 0.287 NA NA
ZRSR2 sunitinib 0.2895406 0.8879684 0.290 NA NA
GNB1 sunitinib 0.2903826 0.8879684 0.290 NA NA
EML4 sunitinib 0.2909234 0.8879684 0.291 NA NA
CD79B sunitinib 0.2950346 0.8879684 0.295 NA NA
GNAQ sunitinib 0.2950346 0.8879684 0.295 NA NA
BTK sunitinib 0.3113123 0.8879684 0.311 NA NA
GATA1 sunitinib 0.3154704 0.8879684 0.315 NA NA
MET sunitinib 0.3589333 0.8879684 0.359 NA NA
MDM2 sunitinib 0.3616422 0.8879684 0.362 NA NA
XPO1 sunitinib 0.3697335 0.8879684 0.370 NA NA
AKT3 sunitinib 0.3829361 0.8879684 0.383 NA NA
RAD21 sunitinib 0.3873632 0.8879684 0.387 NA NA
BCORL1 sunitinib 0.3905032 0.8879684 0.391 NA NA
FGFR1 sunitinib 0.3924162 0.8879684 0.392 NA NA
UGT1A1 sunitinib 0.3992388 0.8879684 0.399 NA NA
PIK3CA sunitinib 0.4133331 0.8879684 0.413 NA NA
AR sunitinib 0.4370527 0.8879684 0.437 NA NA
IKZF1 sunitinib 0.4601764 0.8879684 0.460 NA NA
JAK1 sunitinib 0.4658224 0.8879684 0.466 NA NA
PTCH1 sunitinib 0.4664159 0.8879684 0.466 NA NA
SMC3 sunitinib 0.4719892 0.8879684 0.472 NA NA
MPL sunitinib 0.4753748 0.8879684 0.475 NA NA
PDCD1 sunitinib 0.4810096 0.8879684 0.481 NA NA
CALR sunitinib 0.4811019 0.8879684 0.481 NA NA
ERBB2 sunitinib 0.4842706 0.8879684 0.484 NA NA
PDGFRA sunitinib 0.4989956 0.8879684 0.499 NA NA
WHSC1 sunitinib 0.5013812 0.8879684 0.501 NA NA
PHF6 sunitinib 0.5059450 0.8879684 0.506 NA NA
PDGFRB sunitinib 0.5106193 0.8879684 0.511 NA NA
SF1 sunitinib 0.5144054 0.8879684 0.514 NA NA
JAK3 sunitinib 0.5153903 0.8879684 0.515 NA NA
CYP19A1 sunitinib 0.5166344 0.8879684 0.517 NA NA
BRAF sunitinib 0.5308225 0.8879684 0.531 NA NA
ESR1 sunitinib 0.5643768 0.8879684 0.564 NA NA
FLT3 sunitinib 0.5660424 0.8879684 0.566 NA NA
PDGFB sunitinib 0.5660424 0.8879684 0.566 NA NA
NRAS sunitinib 0.5749041 0.8879684 0.575 NA NA
ABL1 sunitinib 0.5802023 0.8879684 0.580 NA NA
FGFR3 sunitinib 0.5938828 0.8879684 0.594 NA NA
PRPF40B sunitinib 0.5980324 0.8879684 0.598 NA NA
IDH2 sunitinib 0.6010327 0.8879684 0.601 NA NA
VHL sunitinib 0.6024171 0.8879684 0.602 NA NA
CTNNB1 sunitinib 0.6030844 0.8879684 0.603 NA NA
SETD2 sunitinib 0.6036916 0.8879684 0.604 NA NA
ROS1 sunitinib 0.6060667 0.8879684 0.606 NA NA
CSF3R sunitinib 0.6077091 0.8879684 0.608 NA NA
BCOR sunitinib 0.6110543 0.8879684 0.611 NA NA
NOTCH1 sunitinib 0.6162376 0.8879684 0.616 NA NA
AKT2 sunitinib 0.6176121 0.8879684 0.618 NA NA
G6PD sunitinib 0.6213525 0.8879684 0.621 NA NA
PIGA sunitinib 0.6213525 0.8879684 0.621 NA NA
EGFR sunitinib 0.6347395 0.8879684 0.635 NA NA
MGMT sunitinib 0.6441449 0.8879684 0.644 NA NA
PRPF8 sunitinib 0.6502972 0.8879684 0.650 NA NA
MAP2K1 sunitinib 0.6551799 0.8879684 0.655 NA NA
KIT sunitinib 0.6583214 0.8879684 0.658 NA NA
ATM lapatinib 0.3757531 0.8895379 0.3758 NA NA
GNAS dabrafenib 0.4837630 0.8916748 0.48376 NA NA
JAK1 dabrafenib 0.4940334 0.8916748 0.49403 NA NA
PDGFB dabrafenib 0.4964153 0.8916748 0.49642 NA NA
DDIT3 dabrafenib 0.4991662 0.8916748 0.49917 NA NA
ESR1 dabrafenib 0.5138002 0.8916748 0.51380 NA NA
FLT3 dabrafenib 0.5153597 0.8916748 0.51536 NA NA
PAX8 dabrafenib 0.5195687 0.8916748 0.51957 NA NA
RPL10 dabrafenib 0.5241142 0.8916748 0.52411 NA NA
ROS1 midostaurin 0.5814725 0.8921766 0.5815 NA NA
CDK4 midostaurin 0.5892242 0.8921766 0.5892 NA NA
MYCN midostaurin 0.5948521 0.8921766 0.5949 NA NA
GATA3 midostaurin 0.5993247 0.8921766 0.5993 NA NA
PAX8 afatinib 0.4284981 0.8922369 0.4285 NA NA
PDCD1 afatinib 0.4342385 0.8922369 0.4342 NA NA
RET afatinib 0.4515995 0.8922369 0.4516 NA NA
EGFR afatinib 0.4594260 0.8922369 0.4594 NA NA
SMC1A afatinib 0.4735125 0.8922369 0.4735 NA NA
CREBBP afatinib 0.4804225 0.8922369 0.4804 NA NA
PRPF40B afatinib 0.4830174 0.8922369 0.4830 NA NA
CTCF afatinib 0.4847708 0.8922369 0.4848 NA NA
AKT3 afatinib 0.4858445 0.8922369 0.4858 NA NA
PDGFRB afatinib 0.4872986 0.8922369 0.4873 NA NA
SMO cabozantinib 0.6697490 0.8933197 0.6697 NA NA
XPO1 cabozantinib 0.6741548 0.8933197 0.6742 NA NA
IKZF1 cabozantinib 0.6895685 0.8933197 0.6896 NA NA
PML cabozantinib 0.6926459 0.8933197 0.6926 NA NA
PDGFB cabozantinib 0.6931930 0.8933197 0.6932 NA NA
CDKN2A cabozantinib 0.6975307 0.8933197 0.6975 NA NA
IL7R cabozantinib 0.7075726 0.8933197 0.7076 NA NA
PRPF40B cabozantinib 0.7092004 0.8933197 0.7092 NA NA
GATA2 docetaxel 0.6066753 0.8934136 0.60668 NA NA
BRCA2 docetaxel 0.6116514 0.8934136 0.61165 NA NA
EML4 docetaxel 0.6185171 0.8934136 0.61852 NA NA
ESR1 cabozantinib 0.7161231 0.8934488 0.7161 NA NA
PDGFRB alectinib 0.6381495 0.8942058 0.6381 NA NA
RUNX1 alectinib 0.6416439 0.8942058 0.6416 NA NA
NT5C2 gefitinib 0.5963461 0.8942114 0.5963 NA NA
PTEN gefitinib 0.5969493 0.8942114 0.5969 NA NA
GATA2 gefitinib 0.6160722 0.8942114 0.6161 NA NA
DDIT3 gefitinib 0.6170733 0.8942114 0.6171 NA NA
ETV6 gefitinib 0.6204801 0.8942114 0.6205 NA NA
KRAS gefitinib 0.6235545 0.8942114 0.6236 NA NA
SMC3 gefitinib 0.6263365 0.8942114 0.6263 NA NA
FANCL gefitinib 0.6370118 0.8942114 0.6370 NA NA
UGT1A1 gefitinib 0.6466857 0.8942114 0.6467 NA NA
CBLB gefitinib 0.6512627 0.8942114 0.6513 NA NA
TSC2 gefitinib 0.6534622 0.8942114 0.6535 NA NA
IDH2 crizotinib 0.4011464 0.8948650 0.4011 NA NA
ALK tretinoin 0.7717427 0.8957728 0.7717 NA NA
RUNX1 dabrafenib 0.5389208 0.8964207 0.53892 NA NA
PTCH1 dabrafenib 0.5410696 0.8964207 0.54107 NA NA
UGT1A1 dabrafenib 0.5474325 0.8964207 0.54743 NA NA
UGT1A1 alectinib 0.6542466 0.8965374 0.6542 NA NA
NOTCH2 alectinib 0.6570045 0.8965374 0.6570 NA NA
ABL1 nilotinib 0.7313136 0.8968941 0.7313 NA NA
PHF6 lapatinib 0.3938211 0.8970094 0.3938 NA NA
PDCD1 lapatinib 0.4012535 0.8970094 0.4013 NA NA
SETD2 lapatinib 0.4021077 0.8970094 0.4021 NA NA
PTPN11 belinostat 0.0156755 0.8970712 0.01568
NA
TP53 belinostat 0.0391583 0.8970712 0.03916
NA
NRAS belinostat 0.0419064 0.8970712 0.04191
NA
SETBP1 belinostat 0.0619635 0.8970712 0.06196 NA NA
TPMT belinostat 0.0656977 0.8970712 0.06570 NA NA
PDGFRB belinostat 0.0666829 0.8970712 0.06668 NA NA
BRAF belinostat 0.0744959 0.8970712 0.07450 NA NA
DNAJB1 belinostat 0.0814309 0.8970712 0.08143 NA NA
BCOR belinostat 0.0836126 0.8970712 0.08361 NA NA
STAG2 belinostat 0.0851654 0.8970712 0.08517 NA NA
CD274 belinostat 0.0932739 0.8970712 0.09327 NA NA
BCORL1 belinostat 0.1094027 0.8970712 0.10940 NA NA
NCOA2 belinostat 0.1222655 0.8970712 0.12227 NA NA
IDH2 belinostat 0.1232427 0.8970712 0.12324 NA NA
MAP2K2 belinostat 0.1254344 0.8970712 0.12543 NA NA
VHL belinostat 0.1257218 0.8970712 0.12572 NA NA
KMT2A belinostat 0.1296916 0.8970712 0.12969 NA NA
MET belinostat 0.1348014 0.8970712 0.13480 NA NA
CBL belinostat 0.1450619 0.8970712 0.14506 NA NA
NPM1 belinostat 0.1498150 0.8970712 0.14982 NA NA
SF1 belinostat 0.1506532 0.8970712 0.15065 NA NA
DPYD tretinoin 0.7806169 0.8973864 0.7806 NA NA
CXCR4 tretinoin 0.7873492 0.8973864 0.7873 NA NA
CDKN2A tretinoin 0.8022030 0.8973864 0.8022 NA NA
FLCN tretinoin 0.8043691 0.8973864 0.8044 NA NA
FLT3 tretinoin 0.8076478 0.8973864 0.8076 NA NA
U2AF1 afatinib 0.4972408 0.8977958 0.4972 NA NA
JAK1 gefitinib 0.6632200 0.8981105 0.6632 NA NA
FLCN nilotinib 0.7393663 0.8982955 0.7394 NA NA
SF3B1 ruxolitinib 0.6933953 0.8993543 0.6934 NA NA
PTPN11 tretinoin 0.8170201 0.9001069 0.8170 NA NA
SETBP1 erlotinib 0.7514881 0.9002202 0.7515 NA NA
NOTCH1 tretinoin 0.8264829 0.9005863 0.8265 NA NA
MGMT tretinoin 0.8349168 0.9005863 0.8349 NA NA
SMC1A tretinoin 0.8382380 0.9005863 0.8382 NA NA
TET2 ponatinib 0.1895014 0.9011644 0.190 NA NA
ATM ponatinib 0.1926153 0.9011644 0.193 NA NA
NT5C2 midostaurin 0.6123593 0.9013378 0.6124 NA NA
FGFR3 crizotinib 0.4127192 0.9033100 0.4127 NA NA
KIT dasatinib 0.7398951 0.9034509 0.740 NA NA
RET lapatinib 0.4130391 0.9040101 0.4130 NA NA
IDH1 midostaurin 0.6274123 0.9046468 0.6274 NA NA
ZRSR2 midostaurin 0.6464003 0.9046468 0.6464 NA NA
EZH2 midostaurin 0.6468498 0.9046468 0.6468 NA NA
FLT3 midostaurin 0.6526579 0.9046468 0.6527 NA NA
CTLA4 midostaurin 0.6682026 0.9046468 0.6682 NA NA
U2AF1 midostaurin 0.6708859 0.9046468 0.6709 NA NA
HRAS midostaurin 0.6727624 0.9046468 0.6728 NA NA
SF1 midostaurin 0.6811779 0.9046468 0.6812 NA NA
ESR1 midostaurin 0.6835330 0.9046468 0.6835 NA NA
EML4 midostaurin 0.6914164 0.9046468 0.6914 NA NA
ETV6 midostaurin 0.7039964 0.9046468 0.7040 NA NA
NOTCH1 midostaurin 0.7089128 0.9046468 0.7089 NA NA
BTK midostaurin 0.7129549 0.9046468 0.7130 NA NA
ERBB4 midostaurin 0.7168444 0.9046468 0.7168 NA NA
EED midostaurin 0.7259376 0.9046468 0.7259 NA NA
PAX5 midostaurin 0.7382339 0.9046468 0.7382 NA NA
TPMT midostaurin 0.7460273 0.9046468 0.7460 NA NA
PDCD1 midostaurin 0.7514117 0.9046468 0.7514 NA NA
CDC73 midostaurin 0.7520422 0.9046468 0.7520 NA NA
FANCL midostaurin 0.7611087 0.9046468 0.7611 NA NA
SETBP1 midostaurin 0.7737089 0.9046468 0.7737 NA NA
KMT2A midostaurin 0.7807486 0.9046468 0.7807 NA NA
RAD21 midostaurin 0.7818238 0.9046468 0.7818 NA NA
RUNX1 midostaurin 0.7821353 0.9046468 0.7821 NA NA
ASXL1 midostaurin 0.7907471 0.9046468 0.7907 NA NA
BRAF midostaurin 0.7943467 0.9046468 0.7943 NA NA
PHF6 midostaurin 0.8168214 0.9046468 0.8168 NA NA
CD79B midostaurin 0.8277512 0.9046468 0.8278 NA NA
G6PD midostaurin 0.8281741 0.9046468 0.8282 NA NA
WHSC1 midostaurin 0.8326953 0.9046468 0.8327 NA NA
GATA2 midostaurin 0.8338411 0.9046468 0.8338 NA NA
MET midostaurin 0.8355898 0.9046468 0.8356 NA NA
CYP19A1 afatinib 0.5081199 0.9048710 0.5081 NA NA
PML gefitinib 0.6752846 0.9050206 0.6753 NA NA
CDKN2A sunitinib 0.6799349 0.9053535 0.680 NA NA
EZH2 sunitinib 0.6938567 0.9053535 0.694 NA NA
NOTCH2 sunitinib 0.7032998 0.9053535 0.703 NA NA
FBXW7 sunitinib 0.7083621 0.9053535 0.708 NA NA
SMO sunitinib 0.7239446 0.9053535 0.724 NA NA
FANCL sunitinib 0.7369648 0.9053535 0.737 NA NA
EGF sunitinib 0.7398358 0.9053535 0.740 NA NA
IL7R sunitinib 0.7398358 0.9053535 0.740 NA NA
DPYD sunitinib 0.7414533 0.9053535 0.741 NA NA
FGFR2 palbociclib 0.6430949 0.9063294 0.6431 NA NA
SH2B3 palbociclib 0.6434247 0.9063294 0.6434 NA NA
ASXL1 temozolomide 0.7680740 0.9064658 0.76807 NA NA
ETV6 vismodegib 0.0097525 0.9068778 0.0098 ** NA
XPO1 vismodegib 0.0197148 0.9068778 0.0197
NA
GNAQ vismodegib 0.0250242 0.9068778 0.0250
NA
CDC73 vismodegib 0.0366254 0.9068778 0.0366
NA
EZH2 vismodegib 0.0623528 0.9068778 0.0624 NA NA
ZRSR2 vismodegib 0.0682009 0.9068778 0.0682 NA NA
CDK4 vismodegib 0.0707615 0.9068778 0.0708 NA NA
RUNX1 vismodegib 0.0874842 0.9068778 0.0875 NA NA
RPL10 vismodegib 0.0892587 0.9068778 0.0893 NA NA
NCOA2 vismodegib 0.0893861 0.9068778 0.0894 NA NA
SH2B3 vismodegib 0.0934678 0.9068778 0.0935 NA NA
TET2 vismodegib 0.0981762 0.9068778 0.0982 NA NA
CTLA4 vismodegib 0.1069540 0.9068778 0.1070 NA NA
FANCL vismodegib 0.1143467 0.9068778 0.1143 NA NA
STAT3 vismodegib 0.1166536 0.9068778 0.1167 NA NA
JAK2 vismodegib 0.1385135 0.9068778 0.1385 NA NA
RAD21 vismodegib 0.1386885 0.9068778 0.1387 NA NA
WHSC1 vismodegib 0.1543822 0.9068778 0.1544 NA NA
MAP2K1 vismodegib 0.1617145 0.9068778 0.1617 NA NA
BRAF vismodegib 0.1624273 0.9068778 0.1624 NA NA
GNA11 vismodegib 0.1941667 0.9068778 0.1942 NA NA
VHL vismodegib 0.1982659 0.9068778 0.1983 NA NA
IDH2 vismodegib 0.2041835 0.9068778 0.2042 NA NA
EML4 vismodegib 0.2074836 0.9068778 0.2075 NA NA
SRSF2 vismodegib 0.2103014 0.9068778 0.2103 NA NA
BRCA1 vismodegib 0.2203270 0.9068778 0.2203 NA NA
PDGFB vismodegib 0.2233811 0.9068778 0.2234 NA NA
NOTCH1 vismodegib 0.2273665 0.9068778 0.2274 NA NA
KIT vismodegib 0.2326739 0.9068778 0.2327 NA NA
SF3B1 vismodegib 0.2348374 0.9068778 0.2348 NA NA
SMC3 vismodegib 0.2452829 0.9068778 0.2453 NA NA
G6PD vismodegib 0.2460143 0.9068778 0.2460 NA NA
TSC1 vismodegib 0.2476631 0.9068778 0.2477 NA NA
JAK1 vismodegib 0.2513278 0.9068778 0.2513 NA NA
MAP2K2 vismodegib 0.2563401 0.9068778 0.2563 NA NA
CEBPA vismodegib 0.2638745 0.9068778 0.2639 NA NA
TPMT vismodegib 0.2650075 0.9068778 0.2650 NA NA
SETD2 vismodegib 0.2650874 0.9068778 0.2651 NA NA
TSC2 ponatinib 0.2051961 0.9073297 0.205 NA NA
JAK1 ponatinib 0.2077854 0.9073297 0.208 NA NA
CALR gefitinib 0.6884355 0.9074800 0.6884 NA NA
CSF3R gefitinib 0.6946468 0.9074800 0.6946 NA NA
FGFR2 gefitinib 0.6980616 0.9074800 0.6981 NA NA
CD274 trametinib 0.5701244 0.9080774 0.57012 NA NA
TPMT trametinib 0.6050220 0.9080774 0.60502 NA NA
ATM trametinib 0.6061888 0.9080774 0.60619 NA NA
GNA11 trametinib 0.6063817 0.9080774 0.60638 NA NA
EED trametinib 0.6074766 0.9080774 0.60748 NA NA
FLCN trametinib 0.6190484 0.9080774 0.61905 NA NA
AKT1 trametinib 0.6346674 0.9080774 0.63467 NA NA
CD79B trametinib 0.6446579 0.9080774 0.64466 NA NA
PTPN11 trametinib 0.6470969 0.9080774 0.64710 NA NA
SF1 trametinib 0.6556570 0.9080774 0.65566 NA NA
STAG2 trametinib 0.6561590 0.9080774 0.65616 NA NA
MPL trametinib 0.6589843 0.9080774 0.65898 NA NA
TET2 trametinib 0.6734045 0.9080774 0.67340 NA NA
EML4 trametinib 0.6775722 0.9080774 0.67757 NA NA
JAK1 trametinib 0.6886991 0.9080774 0.68870 NA NA
ESR1 trametinib 0.6962680 0.9080774 0.69627 NA NA
SMC3 trametinib 0.6972222 0.9080774 0.69722 NA NA
SMC1A trametinib 0.7004160 0.9080774 0.70042 NA NA
EZH2 trametinib 0.7036019 0.9080774 0.70360 NA NA
SRSF2 trametinib 0.7053488 0.9080774 0.70535 NA NA
CBL trametinib 0.7179539 0.9080774 0.71795 NA NA
CRLF2 trametinib 0.7189639 0.9080774 0.71896 NA NA
EGFR trametinib 0.7194767 0.9080774 0.71948 NA NA
AKT1 vismodegib 0.2724738 0.9082459 0.2725 NA NA
ASXL1 crizotinib 0.4390544 0.9089778 0.4391 NA NA
ESR1 crizotinib 0.4487601 0.9089778 0.4488 NA NA
STAT3 crizotinib 0.4489323 0.9089778 0.4489 NA NA
U2AF1 crizotinib 0.4627036 0.9089778 0.4627 NA NA
SMO crizotinib 0.4736088 0.9089778 0.4736 NA NA
CRLF2 crizotinib 0.4795458 0.9089778 0.4795 NA NA
GNAS crizotinib 0.4890065 0.9089778 0.4890 NA NA
RET crizotinib 0.5041789 0.9089778 0.5042 NA NA
FGFR1 crizotinib 0.5187132 0.9089778 0.5187 NA NA
SF1 crizotinib 0.5238314 0.9089778 0.5238 NA NA
AKT3 crizotinib 0.5260488 0.9089778 0.5260 NA NA
ABL1 crizotinib 0.5320626 0.9089778 0.5321 NA NA
BCORL1 crizotinib 0.5399529 0.9089778 0.5400 NA NA
MGMT crizotinib 0.5501355 0.9089778 0.5501 NA NA
JAK2 crizotinib 0.5623793 0.9089778 0.5624 NA NA
TET2 crizotinib 0.5676235 0.9089778 0.5676 NA NA
PAX8 crizotinib 0.5685501 0.9089778 0.5686 NA NA
IL7R crizotinib 0.5731295 0.9089778 0.5731 NA NA
WT1 crizotinib 0.5747532 0.9089778 0.5748 NA NA
KMT2A crizotinib 0.5794379 0.9089778 0.5794 NA NA
PIK3CA crizotinib 0.5887265 0.9089778 0.5887 NA NA
GATA2 crizotinib 0.5930452 0.9089778 0.5930 NA NA
BRAF crizotinib 0.6026642 0.9089778 0.6027 NA NA
CALR crizotinib 0.6126271 0.9089778 0.6126 NA NA
ETV6 crizotinib 0.6144403 0.9089778 0.6144 NA NA
CYP19A1 crizotinib 0.6190452 0.9089778 0.6190 NA NA
CD274 gefitinib 0.7222314 0.9100743 0.7222 NA NA
MAP2K1 gefitinib 0.7231455 0.9100743 0.7231 NA NA
RUNX1 gefitinib 0.7245837 0.9100743 0.7246 NA NA
GNAQ gefitinib 0.7280594 0.9100743 0.7281 NA NA
IL7R gefitinib 0.7358963 0.9111097 0.7359 NA NA
PTEN nilotinib 0.7611038 0.9112606 0.7611 NA NA
CSF3R nilotinib 0.7665100 0.9112606 0.7665 NA NA
PML nilotinib 0.7777017 0.9112606 0.7777 NA NA
CD79B nilotinib 0.7872284 0.9112606 0.7872 NA NA
AKT2 nilotinib 0.7949272 0.9112606 0.7949 NA NA
AKT3 nilotinib 0.7991714 0.9112606 0.7992 NA NA
KRAS nilotinib 0.8058237 0.9112606 0.8058 NA NA
IDH2 nilotinib 0.8061151 0.9112606 0.8061 NA NA
TET2 afatinib 0.5315227 0.9118564 0.5315 NA NA
GNA11 afatinib 0.5399949 0.9118564 0.5400 NA NA
CD274 afatinib 0.5528302 0.9118564 0.5528 NA NA
PTPN11 afatinib 0.5596334 0.9118564 0.5596 NA NA
ERBB3 afatinib 0.5614904 0.9118564 0.5615 NA NA
SMC3 afatinib 0.5706429 0.9118564 0.5706 NA NA
GNB1 afatinib 0.5781400 0.9118564 0.5781 NA NA
CD79B afatinib 0.5816393 0.9118564 0.5816 NA NA
BRCA1 afatinib 0.5859699 0.9118564 0.5860 NA NA
STAT3 afatinib 0.5862188 0.9118564 0.5862 NA NA
DNAJB1 afatinib 0.5947756 0.9118564 0.5948 NA NA
CDK4 afatinib 0.6107092 0.9118564 0.6107 NA NA
JAK2 afatinib 0.6195384 0.9118564 0.6195 NA NA
ROS1 afatinib 0.6282804 0.9118564 0.6283 NA NA
TPMT afatinib 0.6320485 0.9118564 0.6320 NA NA
SETD2 afatinib 0.6344824 0.9118564 0.6345 NA NA
GATA2 afatinib 0.6361396 0.9118564 0.6361 NA NA
IL7R afatinib 0.6415553 0.9118564 0.6416 NA NA
MYCN afatinib 0.6464575 0.9118564 0.6465 NA NA
PTEN afatinib 0.6523280 0.9118564 0.6523 NA NA
WHSC1 gefitinib 0.7582570 0.9123047 0.7583 NA NA
AKT1 gefitinib 0.7625117 0.9123047 0.7625 NA NA
CTNNB1 gefitinib 0.7648316 0.9123047 0.7648 NA NA
PDGFRB gefitinib 0.7649324 0.9123047 0.7649 NA NA
ERBB2 belinostat 0.1805478 0.9128558 0.18055 NA NA
RIT1 belinostat 0.1819372 0.9128558 0.18194 NA NA
FGFR3 belinostat 0.1830783 0.9128558 0.18308 NA NA
ABL1 belinostat 0.1850848 0.9128558 0.18508 NA NA
EGF belinostat 0.1881458 0.9128558 0.18815 NA NA
KRAS ruxolitinib 0.7137147 0.9146275 0.7137 NA NA
SETBP1 ruxolitinib 0.7191346 0.9146275 0.7191 NA NA
CBLB dabrafenib 0.5660789 0.9155103 0.56608 NA NA
TSC1 cabozantinib 0.7417760 0.9167232 0.7418 NA NA
PRPF8 nilotinib 0.8182825 0.9170407 0.8183 NA NA
FGFR2 ruxolitinib 0.7282503 0.9171646 0.7283 NA NA
PML ruxolitinib 0.7351319 0.9171646 0.7351 NA NA
MYCN rucaparib 0.4390214 0.9173514 0.439 NA NA
XPO1 rucaparib 0.4406168 0.9173514 0.441 NA NA
ABL1 rucaparib 0.4411690 0.9173514 0.441 NA NA
PRPF40B tretinoin 0.8614099 0.9178958 0.8614 NA NA
HRAS afatinib 0.6742292 0.9182537 0.6742 NA NA
CALR afatinib 0.6938848 0.9182537 0.6939 NA NA
SSX1 afatinib 0.6952155 0.9182537 0.6952 NA NA
KMT2A afatinib 0.7030506 0.9182537 0.7031 NA NA
GNAS afatinib 0.7054184 0.9182537 0.7054 NA NA
WT1 afatinib 0.7062470 0.9182537 0.7062 NA NA
CSF3R afatinib 0.7063490 0.9182537 0.7063 NA NA
IL7R palbociclib 0.6625578 0.9184461 0.6626 NA NA
MYD88 palbociclib 0.6675616 0.9184461 0.6676 NA NA
MAP2K1 palbociclib 0.6736365 0.9184461 0.6736 NA NA
BRCA1 palbociclib 0.6850052 0.9184461 0.6850 NA NA
PRPF8 palbociclib 0.6959597 0.9184461 0.6960 NA NA
TET2 palbociclib 0.7041197 0.9184461 0.7041 NA NA
FLCN palbociclib 0.7051976 0.9184461 0.7052 NA NA
ERBB2 palbociclib 0.7083268 0.9184461 0.7083 NA NA
MYCN palbociclib 0.7218549 0.9184461 0.7219 NA NA
CD274 palbociclib 0.7221370 0.9184461 0.7221 NA NA
PDGFRB palbociclib 0.7303977 0.9200202 0.7304 NA NA
ALK docetaxel 0.6482988 0.9200790 0.64830 NA NA
SMC1A docetaxel 0.6559586 0.9200790 0.65596 NA NA
FLCN docetaxel 0.6632639 0.9200790 0.66326 NA NA
PIGA docetaxel 0.6672514 0.9200790 0.66725 NA NA
FLT3 docetaxel 0.6723654 0.9200790 0.67237 NA NA
BTK cabozantinib 0.7515825 0.9201618 0.7516 NA NA
CXCR4 cabozantinib 0.7645614 0.9202001 0.7646 NA NA
WT1 cabozantinib 0.7656627 0.9202001 0.7657 NA NA
IDH1 temozolomide 0.7871872 0.9207279 0.78719 NA NA
CDKN2A dasatinib 0.7625887 0.9214614 0.763 NA NA
U2AF1 pazopanib 0.0404444 0.9218585 0.0404
NA
CEBPA pazopanib 0.0446243 0.9218585 0.0446
NA
GNB1 pazopanib 0.0512813 0.9218585 0.0513 NA NA
NCOA2 pazopanib 0.0647555 0.9218585 0.0648 NA NA
NOTCH2 pazopanib 0.0696792 0.9218585 0.0697 NA NA
CALR pazopanib 0.0961360 0.9218585 0.0961 NA NA
PRPF8 pazopanib 0.1000832 0.9218585 0.1001 NA NA
GNA11 pazopanib 0.1031129 0.9218585 0.1031 NA NA
EED pazopanib 0.1069880 0.9218585 0.1070 NA NA
AKT3 pazopanib 0.1128443 0.9218585 0.1128 NA NA
ETV6 pazopanib 0.1180629 0.9218585 0.1181 NA NA
BTK pazopanib 0.1215251 0.9218585 0.1215 NA NA
FLCN pazopanib 0.1317962 0.9218585 0.1318 NA NA
RPL10 pazopanib 0.1515056 0.9218585 0.1515 NA NA
NRAS pazopanib 0.1573839 0.9218585 0.1574 NA NA
CREBBP pazopanib 0.1610486 0.9218585 0.1610 NA NA
MYCN pazopanib 0.1635137 0.9218585 0.1635 NA NA
FGFR2 pazopanib 0.1667180 0.9218585 0.1667 NA NA
PTEN pazopanib 0.1738665 0.9218585 0.1739 NA NA
STAG2 pazopanib 0.1860023 0.9218585 0.1860 NA NA
DDIT3 pazopanib 0.1903063 0.9218585 0.1903 NA NA
CDKN2A pazopanib 0.2139961 0.9218585 0.2140 NA NA
SF1 pazopanib 0.2189633 0.9218585 0.2190 NA NA
SSX1 pazopanib 0.2368944 0.9218585 0.2369 NA NA
BCORL1 pazopanib 0.2394178 0.9218585 0.2394 NA NA
CRLF2 pazopanib 0.2509570 0.9218585 0.2510 NA NA
PIGA pazopanib 0.2681396 0.9218585 0.2681 NA NA
TP53 pazopanib 0.2688657 0.9218585 0.2689 NA NA
PAX5 pazopanib 0.2868988 0.9218585 0.2869 NA NA
SETBP1 pazopanib 0.2928522 0.9218585 0.2929 NA NA
PTCH1 pazopanib 0.2950783 0.9218585 0.2951 NA NA
FANCL pazopanib 0.2951768 0.9218585 0.2952 NA NA
IDH2 pazopanib 0.3050404 0.9218585 0.3050 NA NA
IL7R pazopanib 0.3205386 0.9218585 0.3205 NA NA
MET pazopanib 0.3375577 0.9218585 0.3376 NA NA
ERBB2 pazopanib 0.3398016 0.9218585 0.3398 NA NA
RAD21 pazopanib 0.3462781 0.9218585 0.3463 NA NA
GATA1 pazopanib 0.3523703 0.9218585 0.3524 NA NA
BRAF pazopanib 0.3592410 0.9218585 0.3592 NA NA
BRCA2 pazopanib 0.3630866 0.9218585 0.3631 NA NA
TSC1 pazopanib 0.3683895 0.9218585 0.3684 NA NA
ATM pazopanib 0.3827853 0.9218585 0.3828 NA NA
DNAJB1 pazopanib 0.3887892 0.9218585 0.3888 NA NA
UGT1A1 pazopanib 0.3984406 0.9218585 0.3984 NA NA
PDCD1 pazopanib 0.4167317 0.9218585 0.4167 NA NA
CD274 pazopanib 0.4298527 0.9218585 0.4299 NA NA
JAK1 pazopanib 0.4308861 0.9218585 0.4309 NA NA
FLT3 pazopanib 0.4421181 0.9218585 0.4421 NA NA
TSC2 pazopanib 0.4425985 0.9218585 0.4426 NA NA
GATA2 pazopanib 0.4469603 0.9218585 0.4470 NA NA
MAP2K2 pazopanib 0.4524699 0.9218585 0.4525 NA NA
FGFR1 pazopanib 0.4634379 0.9218585 0.4634 NA NA
SETD2 pazopanib 0.4675792 0.9218585 0.4676 NA NA
PRPF40B pazopanib 0.4793312 0.9218585 0.4793 NA NA
G6PD pazopanib 0.4835225 0.9218585 0.4835 NA NA
ZRSR2 pazopanib 0.4840326 0.9218585 0.4840 NA NA
ASXL1 pazopanib 0.4847323 0.9218585 0.4847 NA NA
EGF pazopanib 0.4848824 0.9218585 0.4849 NA NA
EZH2 pazopanib 0.4934659 0.9218585 0.4935 NA NA
FBXW7 pazopanib 0.5019388 0.9218585 0.5019 NA NA
ERBB3 pazopanib 0.5092517 0.9218585 0.5093 NA NA
CDK4 pazopanib 0.5102304 0.9218585 0.5102 NA NA
SMC1A pazopanib 0.5163177 0.9218585 0.5163 NA NA
GNAQ pazopanib 0.5212039 0.9218585 0.5212 NA NA
WT1 pazopanib 0.5310459 0.9218585 0.5310 NA NA
GNAS pazopanib 0.5517444 0.9218585 0.5517 NA NA
CYP19A1 pazopanib 0.5523979 0.9218585 0.5524 NA NA
ALK pazopanib 0.5581192 0.9218585 0.5581 NA NA
PML pazopanib 0.5629739 0.9218585 0.5630 NA NA
CDC73 pazopanib 0.5896955 0.9218585 0.5897 NA NA
HRAS pazopanib 0.5941431 0.9218585 0.5941 NA NA
XPO1 pazopanib 0.5942691 0.9218585 0.5943 NA NA
KIT pazopanib 0.5948891 0.9218585 0.5949 NA NA
CSF3R pazopanib 0.6141144 0.9218585 0.6141 NA NA
VHL pazopanib 0.6176221 0.9218585 0.6176 NA NA
AKT1 pazopanib 0.6189835 0.9218585 0.6190 NA NA
MYD88 pazopanib 0.6271722 0.9218585 0.6272 NA NA
SF3B1 pazopanib 0.6294639 0.9218585 0.6295 NA NA
BCOR pazopanib 0.6547699 0.9218585 0.6548 NA NA
MDM2 pazopanib 0.6563096 0.9218585 0.6563 NA NA
IKZF1 pazopanib 0.6580499 0.9218585 0.6580 NA NA
FGFR3 pazopanib 0.6614324 0.9218585 0.6614 NA NA
PDGFRB pazopanib 0.6626651 0.9218585 0.6627 NA NA
ROS1 pazopanib 0.6730661 0.9218585 0.6731 NA NA
CBL pazopanib 0.6735525 0.9218585 0.6736 NA NA
IDH1 pazopanib 0.6864256 0.9218585 0.6864 NA NA
MGMT pazopanib 0.6911734 0.9218585 0.6912 NA NA
RUNX1 pazopanib 0.6915374 0.9218585 0.6915 NA NA
ESR1 pazopanib 0.6922709 0.9218585 0.6923 NA NA
CTLA4 pazopanib 0.6992202 0.9218585 0.6992 NA NA
GATA3 pazopanib 0.7109684 0.9218585 0.7110 NA NA
WHSC1 pazopanib 0.7177667 0.9218585 0.7178 NA NA
JAK3 pazopanib 0.7199383 0.9218585 0.7199 NA NA
SMO pazopanib 0.7247577 0.9218585 0.7248 NA NA
MAP2K1 pazopanib 0.7253435 0.9218585 0.7253 NA NA
DPYD pazopanib 0.7284979 0.9218585 0.7285 NA NA
SMC3 pazopanib 0.7292112 0.9218585 0.7292 NA NA
CBLB pazopanib 0.7358844 0.9218585 0.7359 NA NA
PDGFRA pazopanib 0.7583124 0.9218585 0.7583 NA NA
CTNNB1 pazopanib 0.7592589 0.9218585 0.7593 NA NA
EGFR pazopanib 0.7631271 0.9218585 0.7631 NA NA
CD79B pazopanib 0.7683275 0.9218585 0.7683 NA NA
PHF6 pazopanib 0.7688041 0.9218585 0.7688 NA NA
PDGFB pazopanib 0.7722360 0.9218585 0.7722 NA NA
NPM1 pazopanib 0.7880905 0.9218585 0.7881 NA NA
PAX8 pazopanib 0.7947477 0.9218585 0.7947 NA NA
SH2B3 pazopanib 0.7956485 0.9218585 0.7956 NA NA
AKT2 pazopanib 0.7992674 0.9218585 0.7993 NA NA
PTPN11 pazopanib 0.8056289 0.9218585 0.8056 NA NA
TET2 pazopanib 0.8164348 0.9218585 0.8164 NA NA
PIK3CA pazopanib 0.8224888 0.9218585 0.8225 NA NA
BRCA1 pazopanib 0.8251732 0.9218585 0.8252 NA NA
KMT2A pazopanib 0.8299580 0.9218585 0.8300 NA NA
EML4 pazopanib 0.8328229 0.9218585 0.8328 NA NA
RIT1 pazopanib 0.8336905 0.9218585 0.8337 NA NA
SRSF2 pazopanib 0.8374135 0.9218585 0.8374 NA NA
CREBBP dabrafenib 0.5825405 0.9226353 0.58254 NA NA
VHL dabrafenib 0.5845704 0.9226353 0.58457 NA NA
KRAS sunitinib 0.7642647 0.9226900 0.764 NA NA
U2AF1 sunitinib 0.7759414 0.9226900 0.776 NA NA
MYD88 sunitinib 0.7863908 0.9226900 0.786 NA NA
TP53 sunitinib 0.7929103 0.9226900 0.793 NA NA
JAK2 sunitinib 0.8046870 0.9226900 0.805 NA NA
BRCA1 sunitinib 0.8165800 0.9226900 0.817 NA NA
ERBB4 sunitinib 0.8233327 0.9226900 0.823 NA NA
NCOA2 sunitinib 0.8265853 0.9226900 0.827 NA NA
ERBB3 sunitinib 0.8272393 0.9226900 0.827 NA NA
NOTCH2 palbociclib 0.7431256 0.9230960 0.7431 NA NA
EGFR palbociclib 0.7514260 0.9230960 0.7514 NA NA
TPMT palbociclib 0.7668585 0.9230960 0.7669 NA NA
CYP19A1 palbociclib 0.7672395 0.9230960 0.7672 NA NA
GNAQ palbociclib 0.7733014 0.9230960 0.7733 NA NA
IKZF1 palbociclib 0.7792127 0.9230960 0.7792 NA NA
ETV6 palbociclib 0.7821653 0.9230960 0.7822 NA NA
RAD21 docetaxel 0.6893317 0.9252831 0.68933 NA NA
BRCA1 docetaxel 0.7001716 0.9252831 0.70017 NA NA
ERBB2 docetaxel 0.7052502 0.9252831 0.70525 NA NA
STAT3 docetaxel 0.7071045 0.9252831 0.70710 NA NA
STAG2 docetaxel 0.7117563 0.9252831 0.71176 NA NA
MAP2K1 dabrafenib 0.5935300 0.9256242 0.59353 NA NA
FGFR3 tretinoin 0.8758961 0.9257438 0.8759 NA NA
PRPF40B crizotinib 0.6384729 0.9257857 0.6385 NA NA
FGFR1 tretinoin 0.8836154 0.9263710 0.8836 NA NA
FGFR3 imatinib 0.6868047 0.9263878 0.687 NA NA
BRCA1 gefitinib 0.7929047 0.9271957 0.7929 NA NA
GATA3 gefitinib 0.8010561 0.9271957 0.8011 NA NA
HRAS gefitinib 0.8076126 0.9271957 0.8076 NA NA
U2AF1 gefitinib 0.8094477 0.9271957 0.8094 NA NA
XPO1 gefitinib 0.8161735 0.9271957 0.8162 NA NA
G6PD gefitinib 0.8202116 0.9271957 0.8202 NA NA
RAD21 imatinib 0.6963200 0.9284267 0.696 NA NA
IDH1 sunitinib 0.8485350 0.9285855 0.849 NA NA
MYCN sunitinib 0.8485350 0.9285855 0.849 NA NA
DNMT3A gefitinib 0.8493836 0.9290072 0.8494 NA NA
GNAS gefitinib 0.8530306 0.9290072 0.8530 NA NA
CRLF2 gefitinib 0.8566401 0.9290072 0.8566 NA NA
EML4 gefitinib 0.8568799 0.9290072 0.8569 NA NA
SMO gefitinib 0.8593636 0.9290072 0.8594 NA NA
PTPN11 gefitinib 0.8668680 0.9290072 0.8669 NA NA
PDCD1 gefitinib 0.8718376 0.9290072 0.8718 NA NA
TPMT pazopanib 0.8511938 0.9292199 0.8512 NA NA
SSX1 cabozantinib 0.7843612 0.9293122 0.7844 NA NA
NOTCH1 cabozantinib 0.8021819 0.9293122 0.8022 NA NA
AKT2 cabozantinib 0.8215110 0.9293122 0.8215 NA NA
G6PD cabozantinib 0.8264953 0.9293122 0.8265 NA NA
NCOA2 cabozantinib 0.8330328 0.9293122 0.8330 NA NA
BRCA1 cabozantinib 0.8333837 0.9293122 0.8334 NA NA
ETV6 cabozantinib 0.8369112 0.9293122 0.8369 NA NA
BRAF cabozantinib 0.8425783 0.9293122 0.8426 NA NA
ERBB2 cabozantinib 0.8477762 0.9293122 0.8478 NA NA
STAG2 cabozantinib 0.8502250 0.9293122 0.8502 NA NA
MET cabozantinib 0.8512783 0.9293122 0.8513 NA NA
MET vismodegib 0.2900560 0.9298371 0.2901 NA NA
GNAS vismodegib 0.3041539 0.9298371 0.3042 NA NA
DPYD vismodegib 0.3255816 0.9298371 0.3256 NA NA
RET vismodegib 0.3393340 0.9298371 0.3393 NA NA
CD274 vismodegib 0.3393363 0.9298371 0.3393 NA NA
STAG2 vismodegib 0.3420418 0.9298371 0.3420 NA NA
PDGFRB vismodegib 0.3432087 0.9298371 0.3432 NA NA
DNMT3A vismodegib 0.3575484 0.9298371 0.3575 NA NA
PAX5 vismodegib 0.3631253 0.9298371 0.3631 NA NA
BCOR vismodegib 0.3669291 0.9298371 0.3669 NA NA
FGFR3 vismodegib 0.3855608 0.9298371 0.3856 NA NA
IKZF1 vismodegib 0.3859382 0.9298371 0.3859 NA NA
ESR1 vismodegib 0.3942862 0.9298371 0.3943 NA NA
PTEN vismodegib 0.3964159 0.9298371 0.3964 NA NA
GATA3 vismodegib 0.4109497 0.9298371 0.4109 NA NA
TP53 vismodegib 0.4116935 0.9298371 0.4117 NA NA
RIT1 vismodegib 0.4144232 0.9298371 0.4144 NA NA
CBL vismodegib 0.4259523 0.9298371 0.4260 NA NA
NOTCH2 vismodegib 0.4329752 0.9298371 0.4330 NA NA
SMC1A vismodegib 0.4388743 0.9298371 0.4389 NA NA
NRAS vismodegib 0.4423058 0.9298371 0.4423 NA NA
ATM vismodegib 0.4500064 0.9298371 0.4500 NA NA
KRAS vismodegib 0.4564329 0.9298371 0.4564 NA NA
TSC2 vismodegib 0.4749053 0.9298371 0.4749 NA NA
PDGFRA vismodegib 0.4781819 0.9298371 0.4782 NA NA
AR vismodegib 0.4823074 0.9298371 0.4823 NA NA
HRAS vismodegib 0.4831149 0.9298371 0.4831 NA NA
CBLB vismodegib 0.4886928 0.9298371 0.4887 NA NA
KMT2A vismodegib 0.4929627 0.9298371 0.4930 NA NA
IDH1 vismodegib 0.4935289 0.9298371 0.4935 NA NA
PHF6 ruxolitinib 0.7532871 0.9309492 0.7533 NA NA
GATA3 docetaxel 0.7316455 0.9309922 0.73165 NA NA
EGFR docetaxel 0.7346881 0.9309922 0.73469 NA NA
CEBPA docetaxel 0.7376323 0.9309922 0.73763 NA NA
DPYD ponatinib 0.2315390 0.9319012 0.232 NA NA
BCORL1 ponatinib 0.2327074 0.9319012 0.233 NA NA
KRAS ponatinib 0.2496849 0.9319012 0.250 NA NA
AKT2 ponatinib 0.2512025 0.9319012 0.251 NA NA
IDH2 ponatinib 0.2610616 0.9319012 0.261 NA NA
PTCH1 ponatinib 0.2619913 0.9319012 0.262 NA NA
U2AF1 ponatinib 0.2666179 0.9319012 0.267 NA NA
TP53 ponatinib 0.2715421 0.9319012 0.272 NA NA
PTEN ponatinib 0.2782635 0.9319012 0.278 NA NA
RIT1 ponatinib 0.2845500 0.9319012 0.285 NA NA
IDH2 lapatinib 0.4399819 0.9324389 0.4400 NA NA
KIT lapatinib 0.4421047 0.9324389 0.4421 NA NA
ALK alectinib 0.6916060 0.9326870 0.6916 NA NA
SF3B1 alectinib 0.6977353 0.9326870 0.6977 NA NA
IDH1 cabozantinib 0.8618554 0.9330831 0.8619 NA NA
JAK1 dasatinib 0.7807932 0.9337321 0.781 NA NA
EGF ponatinib 0.2924029 0.9342629 0.292 NA NA
CRLF2 sunitinib 0.8629395 0.9355232 0.863 NA NA
MAP2K1 dasatinib 0.7966385 0.9364046 0.797 NA NA
PRPF8 dasatinib 0.7991729 0.9364046 0.799 NA NA
GNA11 temozolomide 0.8144730 0.9366589 0.81447 NA NA
RET temozolomide 0.8158960 0.9366589 0.81590 NA NA
PHF6 temozolomide 0.8222578 0.9366589 0.82226 NA NA
JAK1 nilotinib 0.8549572 0.9375475 0.8550 NA NA
WT1 nilotinib 0.8552599 0.9375475 0.8553 NA NA
BTK nilotinib 0.8582165 0.9375475 0.8582 NA NA
EML4 afatinib 0.7287764 0.9378890 0.7288 NA NA
AKT1 afatinib 0.7407741 0.9378890 0.7408 NA NA
GATA3 afatinib 0.7430967 0.9378890 0.7431 NA NA
PTCH1 crizotinib 0.6605698 0.9384433 0.6606 NA NA
PDGFB crizotinib 0.6714054 0.9384433 0.6714 NA NA
CTNNB1 crizotinib 0.6714723 0.9384433 0.6715 NA NA
GNAQ belinostat 0.2006145 0.9385892 0.20061 NA NA
KIT docetaxel 0.7747007 0.9402755 0.77470 NA NA
PRPF8 docetaxel 0.7851088 0.9402755 0.78511 NA NA
SH2B3 docetaxel 0.7897952 0.9402755 0.78980 NA NA
PML docetaxel 0.7980096 0.9402755 0.79801 NA NA
BCOR docetaxel 0.7999167 0.9402755 0.79992 NA NA
NRAS docetaxel 0.8083668 0.9402755 0.80837 NA NA
AR docetaxel 0.8129175 0.9402755 0.81292 NA NA
VHL docetaxel 0.8136685 0.9402755 0.81367 NA NA
HRAS docetaxel 0.8151657 0.9402755 0.81517 NA NA
ETV6 docetaxel 0.8173164 0.9402755 0.81732 NA NA
SETD2 palbociclib 0.8046290 0.9403327 0.8046 NA NA
DPYD palbociclib 0.8111267 0.9403327 0.8111 NA NA
MYD88 crizotinib 0.6896981 0.9407860 0.6897 NA NA
BRCA1 crizotinib 0.7017863 0.9407860 0.7018 NA NA
G6PD crizotinib 0.7040235 0.9407860 0.7040 NA NA
RUNX1 crizotinib 0.7117686 0.9407860 0.7118 NA NA
NOTCH1 crizotinib 0.7257254 0.9407860 0.7257 NA NA
PDGFRA crizotinib 0.7390621 0.9407860 0.7391 NA NA
CREBBP crizotinib 0.7392861 0.9407860 0.7393 NA NA
ERBB3 crizotinib 0.7406129 0.9407860 0.7406 NA NA
JAK3 crizotinib 0.7461407 0.9407860 0.7461 NA NA
MAP2K2 afatinib 0.7534845 0.9418556 0.7535 NA NA
MAP2K1 midostaurin 0.8831837 0.9422624 0.8832 NA NA
JAK2 midostaurin 0.8847197 0.9422624 0.8847 NA NA
ERBB3 dasatinib 0.8180600 0.9423316 0.818 NA NA
ETV6 dasatinib 0.8204783 0.9423316 0.820 NA NA
NOTCH2 lapatinib 0.4590405 0.9424799 0.4590 NA NA
CTNNB1 lapatinib 0.4631151 0.9424799 0.4631 NA NA
FLT3 palbociclib 0.8239049 0.9425581 0.8239 NA NA
STAG2 palbociclib 0.8274365 0.9425581 0.8274 NA NA
SETD2 gefitinib 0.8920610 0.9428287 0.8921 NA NA
PIK3CA alectinib 0.7127369 0.9431165 0.7127 NA NA
GATA3 nilotinib 0.8715965 0.9433014 0.8716 NA NA
NOTCH1 nilotinib 0.8779959 0.9433014 0.8780 NA NA
SMC1A rucaparib 0.4701617 0.9438629 0.470 NA NA
PRPF40B rucaparib 0.4712034 0.9438629 0.471 NA NA
NT5C2 rucaparib 0.4816750 0.9438629 0.482 NA NA
ETV6 rucaparib 0.4827390 0.9438629 0.483 NA NA
ESR1 belinostat 0.2186179 0.9445016 0.21862 NA NA
MYD88 belinostat 0.2195610 0.9445016 0.21956 NA NA
ROS1 belinostat 0.2235080 0.9445016 0.22351 NA NA
CRLF2 midostaurin 0.8940790 0.9445512 0.8941 NA NA
NCOA2 trametinib 0.7627476 0.9448097 0.76275 NA NA
G6PD trametinib 0.7631155 0.9448097 0.76312 NA NA
CDK6 docetaxel 0.8387669 0.9449232 0.83877 NA NA
FANCL docetaxel 0.8407316 0.9449232 0.84073 NA NA
GNB1 docetaxel 0.8431622 0.9449232 0.84316 NA NA
KMT2A rucaparib 0.4911204 0.9451799 0.491 NA NA
CXCR4 rucaparib 0.4978429 0.9451799 0.498 NA NA
RIT1 ruxolitinib 0.7720357 0.9452026 0.7720 NA NA
IDH2 imatinib 0.7435570 0.9454698 0.744 NA NA
CSF3R imatinib 0.7445896 0.9454698 0.745 NA NA
GATA2 imatinib 0.7483981 0.9454698 0.748 NA NA
BRCA1 imatinib 0.7500850 0.9454698 0.750 NA NA
KIT imatinib 0.7505218 0.9454698 0.751 NA NA
GNAS imatinib 0.7623301 0.9454698 0.762 NA NA
IL7R imatinib 0.7661566 0.9454698 0.766 NA NA
PHF6 nilotinib 0.8886369 0.9469081 0.8886 NA NA
SH2B3 trametinib 0.7727573 0.9477213 0.77276 NA NA
FGFR1 cabozantinib 0.8867029 0.9486118 0.8867 NA NA
BRCA2 cabozantinib 0.8957636 0.9486118 0.8958 NA NA
CREBBP cabozantinib 0.9124382 0.9486118 0.9124 NA NA
EGFR cabozantinib 0.9149328 0.9486118 0.9149 NA NA
CBL cabozantinib 0.9234314 0.9486118 0.9234 NA NA
UGT1A1 cabozantinib 0.9262331 0.9486118 0.9262 NA NA
SF3B1 cabozantinib 0.9332356 0.9486118 0.9332 NA NA
ATM cabozantinib 0.9341291 0.9486118 0.9341 NA NA
CALR palbociclib 0.8402810 0.9489381 0.8403 NA NA
UGT1A1 docetaxel 0.8542969 0.9492188 0.85430 NA NA
CTCF dasatinib 0.8347924 0.9493717 0.835 NA NA
MAP2K2 temozolomide 0.8411007 0.9498637 0.84110 NA NA
EML4 dasatinib 0.8456669 0.9501391 0.846 NA NA
MET dasatinib 0.8543593 0.9501391 0.854 NA NA
IL7R dasatinib 0.8625869 0.9501391 0.863 NA NA
G6PD dasatinib 0.8682306 0.9501391 0.868 NA NA
CDK4 nilotinib 0.8998193 0.9502052 0.8998 NA NA
GATA2 nilotinib 0.9063496 0.9502052 0.9063 NA NA
PML vismodegib 0.5118312 0.9505437 0.5118 NA NA
PAX8 temozolomide 0.8489663 0.9505521 0.84897 NA NA
NCOA2 docetaxel 0.8662319 0.9509943 0.86623 NA NA
GATA1 docetaxel 0.8709152 0.9509943 0.87092 NA NA
ERBB4 docetaxel 0.8816840 0.9509943 0.88168 NA NA
DNAJB1 docetaxel 0.8861532 0.9509943 0.88615 NA NA
GNAS docetaxel 0.8970312 0.9509943 0.89703 NA NA
ERBB3 docetaxel 0.9076995 0.9509943 0.90770 NA NA
PRPF40B docetaxel 0.9187358 0.9509943 0.91874 NA NA
IL7R docetaxel 0.9196203 0.9509943 0.91962 NA NA
JAK1 docetaxel 0.9217329 0.9509943 0.92173 NA NA
SRSF2 dabrafenib 0.6268440 0.9519179 0.62684 NA NA
FLCN dabrafenib 0.6398583 0.9519179 0.63986 NA NA
PTPN11 dabrafenib 0.6445988 0.9519179 0.64460 NA NA
SF1 dabrafenib 0.6557616 0.9519179 0.65576 NA NA
SMC1A dabrafenib 0.6573321 0.9519179 0.65733 NA NA
BCOR dabrafenib 0.6681638 0.9519179 0.66816 NA NA
DNMT3A dabrafenib 0.6722330 0.9519179 0.67223 NA NA
CEBPA dabrafenib 0.6842945 0.9519179 0.68429 NA NA
BRCA1 dabrafenib 0.6846752 0.9519179 0.68468 NA NA
IL7R dabrafenib 0.6901632 0.9519179 0.69016 NA NA
HRAS dabrafenib 0.7049847 0.9519179 0.70498 NA NA
RET dabrafenib 0.7105653 0.9519179 0.71057 NA NA
U2AF1 dabrafenib 0.7110632 0.9519179 0.71106 NA NA
SF3B1 dabrafenib 0.7152721 0.9519179 0.71527 NA NA
SMO dabrafenib 0.7212576 0.9519179 0.72126 NA NA
GNA11 dabrafenib 0.7266549 0.9519179 0.72665 NA NA
CTLA4 dabrafenib 0.7416236 0.9524934 0.74162 NA NA
FBXW7 dabrafenib 0.7471349 0.9524934 0.74713 NA NA
ERBB4 dabrafenib 0.7535485 0.9524934 0.75355 NA NA
SSX1 dabrafenib 0.7561779 0.9524934 0.75618 NA NA
SSX1 ruxolitinib 0.7939998 0.9527661 0.7940 NA NA
ERBB4 ruxolitinib 0.7989163 0.9527661 0.7989 NA NA
DNAJB1 ruxolitinib 0.8017173 0.9527661 0.8017 NA NA
IDH2 ruxolitinib 0.8073056 0.9527661 0.8073 NA NA
CTCF vismodegib 0.5249865 0.9543342 0.5250 NA NA
NT5C2 vismodegib 0.5285543 0.9543342 0.5286 NA NA
AKT2 afatinib 0.7723890 0.9562912 0.7724 NA NA
STAT3 palbociclib 0.8543064 0.9565311 0.8543 NA NA
ROS1 palbociclib 0.8627523 0.9578013 0.8628 NA NA
BCORL1 trametinib 0.7977582 0.9581364 0.79776 NA NA
ERBB3 trametinib 0.8021031 0.9581364 0.80210 NA NA
CTLA4 trametinib 0.8080516 0.9581364 0.80805 NA NA
NT5C2 trametinib 0.8128743 0.9581364 0.81287 NA NA
PHF6 trametinib 0.8279218 0.9581364 0.82792 NA NA
MET trametinib 0.8326323 0.9581364 0.83263 NA NA
CXCR4 trametinib 0.8340020 0.9581364 0.83400 NA NA
GNAS trametinib 0.8402119 0.9581364 0.84021 NA NA
JAK2 pazopanib 0.8907594 0.9590344 0.8908 NA NA
MPL pazopanib 0.8975234 0.9590344 0.8975 NA NA
NT5C2 pazopanib 0.9014251 0.9590344 0.9014 NA NA
NOTCH1 pazopanib 0.9077883 0.9590344 0.9078 NA NA
SMC3 crizotinib 0.7765258 0.9596512 0.7765 NA NA
EGF crizotinib 0.7795860 0.9596512 0.7796 NA NA
PDGFRB crizotinib 0.8019048 0.9596512 0.8019 NA NA
ZRSR2 crizotinib 0.8231357 0.9596512 0.8231 NA NA
WHSC1 crizotinib 0.8232275 0.9596512 0.8232 NA NA
CBLB crizotinib 0.8413325 0.9596512 0.8413 NA NA
EML4 crizotinib 0.8463945 0.9596512 0.8464 NA NA
KRAS crizotinib 0.8512775 0.9596512 0.8513 NA NA
CXCR4 crizotinib 0.8549228 0.9596512 0.8549 NA NA
CD79B crizotinib 0.8619832 0.9596512 0.8620 NA NA
GNAQ crizotinib 0.8619832 0.9596512 0.8620 NA NA
SF3B1 crizotinib 0.8672340 0.9596512 0.8672 NA NA
KIT crizotinib 0.8686498 0.9596512 0.8686 NA NA
FGFR2 sunitinib 0.8937255 0.9599274 0.894 NA NA
TSC1 gefitinib 0.9156569 0.9599629 0.9157 NA NA
GATA2 lapatinib 0.4800955 0.9601909 0.4801 NA NA
SETD2 temozolomide 0.8680092 0.9609503 0.86801 NA NA
SRSF2 temozolomide 0.8729244 0.9609503 0.87292 NA NA
DDIT3 rucaparib 0.5186394 0.9613594 0.519 NA NA
FGFR3 rucaparib 0.5246724 0.9613594 0.525 NA NA
CEBPA rucaparib 0.5399967 0.9613594 0.540 NA NA
FBXW7 rucaparib 0.5434920 0.9613594 0.543 NA NA
BTK rucaparib 0.5488597 0.9613594 0.549 NA NA
G6PD rucaparib 0.5646292 0.9613594 0.565 NA NA
BRCA1 rucaparib 0.5768966 0.9613594 0.577 NA NA
ALK rucaparib 0.5819295 0.9613594 0.582 NA NA
TSC2 rucaparib 0.5851976 0.9613594 0.585 NA NA
STAT3 rucaparib 0.5946002 0.9613594 0.595 NA NA
PML rucaparib 0.5950165 0.9613594 0.595 NA NA
SMO rucaparib 0.6056010 0.9613594 0.606 NA NA
FGFR1 rucaparib 0.6079969 0.9613594 0.608 NA NA
SETD2 rucaparib 0.6306943 0.9613594 0.631 NA NA
ASXL1 rucaparib 0.6357840 0.9613594 0.636 NA NA
CD79B rucaparib 0.6412203 0.9613594 0.641 NA NA
NPM1 rucaparib 0.6448258 0.9613594 0.645 NA NA
PHF6 rucaparib 0.6451245 0.9613594 0.645 NA NA
PDGFB rucaparib 0.6469333 0.9613594 0.647 NA NA
NRAS rucaparib 0.6737269 0.9613594 0.674 NA NA
CDK4 rucaparib 0.6760802 0.9613594 0.676 NA NA
AKT1 rucaparib 0.6766724 0.9613594 0.677 NA NA
ERBB2 rucaparib 0.6813788 0.9613594 0.681 NA NA
KRAS rucaparib 0.6847697 0.9613594 0.685 NA NA
FGFR2 rucaparib 0.7108197 0.9613594 0.711 NA NA
HRAS rucaparib 0.7110377 0.9613594 0.711 NA NA
ERBB3 rucaparib 0.7263040 0.9613594 0.726 NA NA
FANCL rucaparib 0.7358289 0.9613594 0.736 NA NA
CSF3R rucaparib 0.7397162 0.9613594 0.740 NA NA
ATM rucaparib 0.7486752 0.9613594 0.749 NA NA
MAP2K1 rucaparib 0.7521890 0.9613594 0.752 NA NA
PAX8 rucaparib 0.7606800 0.9613594 0.761 NA NA
TPMT rucaparib 0.7619662 0.9613594 0.762 NA NA
STAG2 rucaparib 0.7624445 0.9613594 0.762 NA NA
GATA2 rucaparib 0.7793422 0.9613594 0.779 NA NA
JAK1 rucaparib 0.7793843 0.9613594 0.779 NA NA
EGFR rucaparib 0.7812134 0.9613594 0.781 NA NA
MET rucaparib 0.7852325 0.9613594 0.785 NA NA
WT1 vismodegib 0.5404655 0.9624727 0.5405 NA NA
ZRSR2 erlotinib 0.8179957 0.9632433 0.8180 NA NA
CREBBP erlotinib 0.8208508 0.9632433 0.8209 NA NA
MYD88 imatinib 0.7889569 0.9633579 0.789 NA NA
CTCF pazopanib 0.9276294 0.9636959 0.9276 NA NA
AR pazopanib 0.9277609 0.9636959 0.9278 NA NA
STAT3 pazopanib 0.9342701 0.9636959 0.9343 NA NA
CYP19A1 lapatinib 0.4937490 0.9639975 0.4937 NA NA
ERBB3 lapatinib 0.5028840 0.9639975 0.5029 NA NA
GATA1 lapatinib 0.5069297 0.9639975 0.5069 NA NA
PRPF8 erlotinib 0.8511983 0.9642623 0.8512 NA NA
DPYD erlotinib 0.8604995 0.9642623 0.8605 NA NA
GNB1 erlotinib 0.8604995 0.9642623 0.8605 NA NA
ERBB4 erlotinib 0.8652272 0.9642623 0.8652 NA NA
CXCR4 erlotinib 0.8802653 0.9642623 0.8803 NA NA
EML4 erlotinib 0.8868224 0.9642623 0.8868 NA NA
TET2 erlotinib 0.8873786 0.9642623 0.8874 NA NA
SETD2 erlotinib 0.9034192 0.9642623 0.9034 NA NA
ESR1 erlotinib 0.9133687 0.9642623 0.9134 NA NA
CBLB erlotinib 0.9170458 0.9642623 0.9170 NA NA
EGFR erlotinib 0.9218958 0.9642623 0.9219 NA NA
PTCH1 erlotinib 0.9275623 0.9642623 0.9276 NA NA
RET erlotinib 0.9307227 0.9642623 0.9307 NA NA
PTCH1 rucaparib 0.7952280 0.9645822 0.795 NA NA
AKT3 rucaparib 0.8101446 0.9647678 0.810 NA NA
WHSC1 rucaparib 0.8131544 0.9647678 0.813 NA NA
TET2 rucaparib 0.8260219 0.9647678 0.826 NA NA
CYP19A1 rucaparib 0.8350834 0.9647678 0.835 NA NA
RET rucaparib 0.8423514 0.9647678 0.842 NA NA
UGT1A1 rucaparib 0.8467310 0.9647678 0.847 NA NA
GATA3 rucaparib 0.8515819 0.9647678 0.852 NA NA
CTNNB1 rucaparib 0.8579792 0.9647678 0.858 NA NA
PAX5 rucaparib 0.8616629 0.9647678 0.862 NA NA
WT1 alectinib 0.7365097 0.9648277 0.7365 NA NA
PIGA alectinib 0.7603016 0.9650018 0.7603 NA NA
DNMT3A alectinib 0.7613631 0.9650018 0.7614 NA NA
MGMT alectinib 0.7636616 0.9650018 0.7637 NA NA
CBLB alectinib 0.7661083 0.9650018 0.7661 NA NA
MYD88 gefitinib 0.9283678 0.9655025 0.9284 NA NA
FGFR2 dasatinib 0.8929128 0.9655770 0.893 NA NA
MGMT dasatinib 0.8989855 0.9655770 0.899 NA NA
FLT3 ruxolitinib 0.8312495 0.9657969 0.8312 NA NA
FBXW7 ruxolitinib 0.8330920 0.9657969 0.8331 NA NA
GATA1 vismodegib 0.5583929 0.9659607 0.5584 NA NA
CSF3R vismodegib 0.5693374 0.9659607 0.5693 NA NA
BTK vismodegib 0.5724794 0.9659607 0.5725 NA NA
PRPF8 vismodegib 0.5766264 0.9659607 0.5766 NA NA
FBXW7 vismodegib 0.5934236 0.9659607 0.5934 NA NA
CDK6 vismodegib 0.5972260 0.9659607 0.5972 NA NA
MYD88 vismodegib 0.5979041 0.9659607 0.5979 NA NA
ERBB4 vismodegib 0.6099615 0.9659607 0.6100 NA NA
GATA2 vismodegib 0.6168478 0.9659607 0.6168 NA NA
PDCD1 vismodegib 0.6201762 0.9659607 0.6202 NA NA
MPL vismodegib 0.6241592 0.9659607 0.6242 NA NA
AR palbociclib 0.8839747 0.9665899 0.8840 NA NA
CTLA4 palbociclib 0.8909703 0.9665899 0.8910 NA NA
PRPF40B palbociclib 0.8948596 0.9665899 0.8949 NA NA
SMC1A palbociclib 0.9001829 0.9665899 0.9002 NA NA
RPL10 temozolomide 0.8989536 0.9673953 0.89895 NA NA
AKT1 temozolomide 0.9094399 0.9673953 0.90944 NA NA
KMT2A temozolomide 0.9165748 0.9673953 0.91657 NA NA
G6PD temozolomide 0.9184100 0.9673953 0.91841 NA NA
SF3B1 temozolomide 0.9259576 0.9673953 0.92596 NA NA
EML4 temozolomide 0.9305234 0.9673953 0.93052 NA NA
BTK temozolomide 0.9330073 0.9673953 0.93301 NA NA
FANCL temozolomide 0.9438077 0.9673953 0.94381 NA NA
CSF3R temozolomide 0.9503618 0.9673953 0.95036 NA NA
BRCA1 temozolomide 0.9526259 0.9673953 0.95263 NA NA
DDIT3 afatinib 0.7931329 0.9681667 0.7931 NA NA
FLT3 afatinib 0.8043606 0.9681667 0.8044 NA NA
NCOA2 afatinib 0.8224551 0.9681667 0.8225 NA NA
PRPF8 afatinib 0.8232418 0.9681667 0.8232 NA NA
JAK1 afatinib 0.8434616 0.9681667 0.8435 NA NA
JAK3 afatinib 0.8440781 0.9681667 0.8441 NA NA
FLCN afatinib 0.8573994 0.9681667 0.8574 NA NA
RUNX1 afatinib 0.8597949 0.9681667 0.8598 NA NA
CRLF2 afatinib 0.8603484 0.9681667 0.8603 NA NA
GNAQ afatinib 0.8603484 0.9681667 0.8603 NA NA
NPM1 afatinib 0.8655570 0.9681667 0.8656 NA NA
WHSC1 afatinib 0.8804758 0.9681667 0.8805 NA NA
AR afatinib 0.8812495 0.9681667 0.8812 NA NA
IDH1 afatinib 0.8943509 0.9681667 0.8944 NA NA
IKZF1 afatinib 0.8947795 0.9681667 0.8948 NA NA
BRAF afatinib 0.9011510 0.9681667 0.9012 NA NA
BCOR afatinib 0.9121893 0.9681667 0.9122 NA NA
NT5C2 afatinib 0.9160346 0.9681667 0.9160 NA NA
GNAQ cabozantinib 0.9622409 0.9696427 0.9622 NA NA
WT1 ruxolitinib 0.8454506 0.9709306 0.8455 NA NA
JAK2 ruxolitinib 0.8523436 0.9709306 0.8523 NA NA
ROS1 crizotinib 0.9055984 0.9716963 0.9056 NA NA
CDKN2A crizotinib 0.9099113 0.9716963 0.9099 NA NA
JAK1 crizotinib 0.9136622 0.9716963 0.9137 NA NA
TP53 crizotinib 0.9190956 0.9716963 0.9191 NA NA
IDH1 crizotinib 0.9332905 0.9716963 0.9333 NA NA
MYCN crizotinib 0.9332905 0.9716963 0.9333 NA NA
BTK crizotinib 0.9381895 0.9716963 0.9382 NA NA
BRCA2 sunitinib 0.9151190 0.9719215 0.915 NA NA
NPM1 sunitinib 0.9216497 0.9719215 0.922 NA NA
RIT1 trametinib 0.8654388 0.9719490 0.86544 NA NA
NPM1 trametinib 0.8672776 0.9719490 0.86728 NA NA
FLCN temozolomide 0.9645329 0.9719524 0.96453 NA NA
FANCL lapatinib 0.5224774 0.9721633 0.5225 NA NA
JAK3 lapatinib 0.5279853 0.9721633 0.5280 NA NA
STAT3 dabrafenib 0.7798325 0.9729339 0.77983 NA NA
PTCH1 belinostat 0.2376997 0.9730830 0.23770 NA NA
SETD2 docetaxel 0.9506315 0.9730874 0.95063 NA NA
TSC1 afatinib 0.9300086 0.9743215 0.9300 NA NA
ESR1 afatinib 0.9503087 0.9743215 0.9503 NA NA
FGFR2 afatinib 0.9511520 0.9743215 0.9512 NA NA
PML afatinib 0.9518372 0.9743215 0.9518 NA NA
VHL cabozantinib 0.9746401 0.9746401 0.9746 NA NA
TP53 alectinib 0.7812268 0.9746735 0.7812 NA NA
RET pazopanib 0.9581510 0.9747513 0.9582 NA NA
CXCR4 pazopanib 0.9598696 0.9747513 0.9599 NA NA
BRAF dasatinib 0.9161548 0.9749904 0.916 NA NA
PDCD1 tretinoin 0.9379623 0.9754808 0.9380 NA NA
XPO1 midostaurin 0.9469456 0.9775663 0.9469 NA NA
IDH2 midostaurin 0.9477169 0.9775663 0.9477 NA NA
RIT1 midostaurin 0.9477169 0.9775663 0.9477 NA NA
AKT1 docetaxel 0.9695144 0.9786645 0.96951 NA NA
SMC3 docetaxel 0.9711363 0.9786645 0.97114 NA NA
RIT1 temozolomide 0.9786787 0.9786787 0.97868 NA NA
RET midostaurin 0.9563247 0.9787385 0.9563 NA NA
ETV6 erlotinib 0.9532871 0.9788215 0.9533 NA NA
SH2B3 bosutinib monohydrate 0.0467380 0.9795951 0.0467
NA
TSC1 bosutinib monohydrate 0.0576889 0.9795951 0.0577 NA NA
VHL bosutinib monohydrate 0.0669017 0.9795951 0.0669 NA NA
CDKN2A bosutinib monohydrate 0.0688711 0.9795951 0.0689 NA NA
CTLA4 bosutinib monohydrate 0.0999893 0.9795951 0.1000 NA NA
BTK bosutinib monohydrate 0.1001931 0.9795951 0.1002 NA NA
MAP2K2 bosutinib monohydrate 0.1046536 0.9795951 0.1047 NA NA
G6PD bosutinib monohydrate 0.1162560 0.9795951 0.1163 NA NA
RPL10 bosutinib monohydrate 0.1218958 0.9795951 0.1219 NA NA
UGT1A1 bosutinib monohydrate 0.1252560 0.9795951 0.1253 NA NA
GATA2 bosutinib monohydrate 0.1441992 0.9795951 0.1442 NA NA
AKT1 bosutinib monohydrate 0.1516806 0.9795951 0.1517 NA NA
GNAS bosutinib monohydrate 0.1636359 0.9795951 0.1636 NA NA
GATA1 bosutinib monohydrate 0.1718658 0.9795951 0.1719 NA NA
PTCH1 bosutinib monohydrate 0.1879013 0.9795951 0.1879 NA NA
MAP2K1 bosutinib monohydrate 0.2099067 0.9795951 0.2099 NA NA
PTPN11 bosutinib monohydrate 0.2124694 0.9795951 0.2125 NA NA
SF1 bosutinib monohydrate 0.2126871 0.9795951 0.2127 NA NA
BCORL1 bosutinib monohydrate 0.2167334 0.9795951 0.2167 NA NA
PAX5 bosutinib monohydrate 0.2299628 0.9795951 0.2300 NA NA
PDCD1 bosutinib monohydrate 0.2330839 0.9795951 0.2331 NA NA
EGF bosutinib monohydrate 0.2453569 0.9795951 0.2454 NA NA
CBLB bosutinib monohydrate 0.2461824 0.9795951 0.2462 NA NA
IDH2 bosutinib monohydrate 0.2477175 0.9795951 0.2477 NA NA
CTNNB1 bosutinib monohydrate 0.2477885 0.9795951 0.2478 NA NA
BRCA1 bosutinib monohydrate 0.2550079 0.9795951 0.2550 NA NA
SMC1A bosutinib monohydrate 0.2743651 0.9795951 0.2744 NA NA
RIT1 bosutinib monohydrate 0.2754670 0.9795951 0.2755 NA NA
EML4 bosutinib monohydrate 0.2755994 0.9795951 0.2756 NA NA
DNAJB1 bosutinib monohydrate 0.2768690 0.9795951 0.2769 NA NA
GNB1 bosutinib monohydrate 0.2886360 0.9795951 0.2886 NA NA
BRCA2 bosutinib monohydrate 0.2907814 0.9795951 0.2908 NA NA
ROS1 bosutinib monohydrate 0.2963370 0.9795951 0.2963 NA NA
PAX8 bosutinib monohydrate 0.3070631 0.9795951 0.3071 NA NA
NOTCH1 bosutinib monohydrate 0.3085065 0.9795951 0.3085 NA NA
SF3B1 bosutinib monohydrate 0.3173562 0.9795951 0.3174 NA NA
RAD21 bosutinib monohydrate 0.3221870 0.9795951 0.3222 NA NA
CDC73 bosutinib monohydrate 0.3226723 0.9795951 0.3227 NA NA
TET2 bosutinib monohydrate 0.3227747 0.9795951 0.3228 NA NA
ERBB3 bosutinib monohydrate 0.3381914 0.9795951 0.3382 NA NA
CEBPA bosutinib monohydrate 0.3405298 0.9795951 0.3405 NA NA
GNAQ bosutinib monohydrate 0.3420516 0.9795951 0.3421 NA NA
MET bosutinib monohydrate 0.3480988 0.9795951 0.3481 NA NA
STAG2 bosutinib monohydrate 0.3541613 0.9795951 0.3542 NA NA
GATA3 erlotinib 0.9653874 0.9799657 0.9654 NA NA
MDM2 erlotinib 0.9714442 0.9799657 0.9714 NA NA
MAP2K2 tretinoin 0.9548035 0.9803243 0.9548 NA NA
GATA1 tretinoin 0.9577014 0.9803243 0.9577 NA NA
NOTCH1 dabrafenib 0.7939637 0.9812193 0.79396 NA NA
FLT3 alectinib 0.7941809 0.9814878 0.7942 NA NA
EED palbociclib 0.9217317 0.9816817 0.9217 NA NA
STAT3 trametinib 0.8932780 0.9821514 0.89328 NA NA
PML trametinib 0.8969530 0.9821514 0.89695 NA NA
SSX1 trametinib 0.8990463 0.9821514 0.89905 NA NA
ERBB4 pazopanib 0.9762228 0.9837322 0.9762 NA NA
SETD2 crizotinib 0.9583372 0.9837798 0.9583 NA NA
NOTCH2 trametinib 0.9359551 0.9839656 0.93596 NA NA
VHL trametinib 0.9375075 0.9839656 0.93751 NA NA
FBXW7 trametinib 0.9408952 0.9839656 0.94090 NA NA
BRCA2 trametinib 0.9421624 0.9839656 0.94216 NA NA
SMO trametinib 0.9533365 0.9839656 0.95334 NA NA
PRPF8 trametinib 0.9559535 0.9839656 0.95595 NA NA
PAX5 trametinib 0.9686829 0.9839656 0.96868 NA NA
AKT2 trametinib 0.9713673 0.9839656 0.97137 NA NA
PDGFRB trametinib 0.9784811 0.9839656 0.97848 NA NA
PIK3CA trametinib 0.9832477 0.9839656 0.98325 NA NA
PAX8 trametinib 0.9839656 0.9839656 0.98397 NA NA
ASXL1 sunitinib 0.9421871 0.9842410 0.942 NA NA
CBLB sunitinib 0.9503016 0.9842410 0.950 NA NA
STAG2 dasatinib 0.9411192 0.9852367 0.941 NA NA
ROS1 dasatinib 0.9512458 0.9852367 0.951 NA NA
AKT2 dasatinib 0.9512631 0.9852367 0.951 NA NA
TET2 sunitinib 0.9597590 0.9852393 0.960 NA NA
NOTCH1 imatinib 0.8157654 0.9857165 0.816 NA NA
NPM1 bosutinib monohydrate 0.3813570 0.9862194 0.3814 NA NA
ERBB2 bosutinib monohydrate 0.3828642 0.9862194 0.3829 NA NA
MDM2 bosutinib monohydrate 0.3854602 0.9862194 0.3855 NA NA
IL7R bosutinib monohydrate 0.3981162 0.9862194 0.3981 NA NA
PDGFRA bosutinib monohydrate 0.4175132 0.9862194 0.4175 NA NA
ZRSR2 bosutinib monohydrate 0.4214919 0.9862194 0.4215 NA NA
ASXL1 bosutinib monohydrate 0.4226760 0.9862194 0.4227 NA NA
CXCR4 bosutinib monohydrate 0.4378881 0.9862194 0.4379 NA NA
SETD2 bosutinib monohydrate 0.4409242 0.9862194 0.4409 NA NA
U2AF1 bosutinib monohydrate 0.4415049 0.9862194 0.4415 NA NA
PML bosutinib monohydrate 0.4556704 0.9862194 0.4557 NA NA
MPL bosutinib monohydrate 0.4577383 0.9862194 0.4577 NA NA
DPYD bosutinib monohydrate 0.4594664 0.9862194 0.4595 NA NA
XPO1 bosutinib monohydrate 0.4627645 0.9862194 0.4628 NA NA
PDGFRA dasatinib 0.9608776 0.9863876 0.961 NA NA
PTEN dabrafenib 0.8142047 0.9866077 0.81420 NA NA
PRPF8 dabrafenib 0.8146043 0.9866077 0.81460 NA NA
TSC1 dabrafenib 0.8273766 0.9866077 0.82738 NA NA
EML4 dabrafenib 0.8284492 0.9866077 0.82845 NA NA
BRCA2 ruxolitinib 0.8869414 0.9866703 0.8869 NA NA
SETD2 ruxolitinib 0.8932673 0.9866703 0.8933 NA NA
CDK4 ruxolitinib 0.8949990 0.9866703 0.8950 NA NA
ROS1 ruxolitinib 0.8966205 0.9866703 0.8966 NA NA
CD79B ruxolitinib 0.9154477 0.9866703 0.9154 NA NA
PDGFRA ruxolitinib 0.9248089 0.9866703 0.9248 NA NA
EML4 ruxolitinib 0.9311316 0.9866703 0.9311 NA NA
PRPF8 ruxolitinib 0.9509706 0.9866703 0.9510 NA NA
UGT1A1 ruxolitinib 0.9514154 0.9866703 0.9514 NA NA
MPL ruxolitinib 0.9628412 0.9866703 0.9628 NA NA
CRLF2 ruxolitinib 0.9649859 0.9866703 0.9650 NA NA
AKT2 ruxolitinib 0.9698154 0.9866703 0.9698 NA NA
GATA2 ruxolitinib 0.9725671 0.9866703 0.9726 NA NA
ATM ruxolitinib 0.9769582 0.9866703 0.9770 NA NA
SMC1A ruxolitinib 0.9791385 0.9866703 0.9791 NA NA
XPO1 belinostat 0.2503343 0.9870331 0.25033 NA NA
HRAS belinostat 0.2579401 0.9870331 0.25794 NA NA
JAK3 belinostat 0.2699558 0.9870331 0.26996 NA NA
ALK belinostat 0.2712457 0.9870331 0.27125 NA NA
SH2B3 gefitinib 0.9659820 0.9877838 0.9660 NA NA
NCOA2 gefitinib 0.9667617 0.9877838 0.9668 NA NA
AKT3 gefitinib 0.9813410 0.9877838 0.9813 NA NA
ATM gefitinib 0.9830253 0.9877838 0.9830 NA NA
KMT2A gefitinib 0.9877838 0.9877838 0.9878 NA NA
GNAS lapatinib 0.5469657 0.9878187 0.5470 NA NA
FLT3 lapatinib 0.5679419 0.9878187 0.5679 NA NA
CDK6 lapatinib 0.5808070 0.9878187 0.5808 NA NA
EGFR lapatinib 0.5960871 0.9878187 0.5961 NA NA
MDM2 lapatinib 0.6102843 0.9878187 0.6103 NA NA
TP53 lapatinib 0.6134430 0.9878187 0.6134 NA NA
FGFR2 lapatinib 0.6157059 0.9878187 0.6157 NA NA
ZRSR2 lapatinib 0.6268747 0.9878187 0.6269 NA NA
ETV6 lapatinib 0.6320960 0.9878187 0.6321 NA NA
KRAS lapatinib 0.6456344 0.9878187 0.6456 NA NA
SETBP1 lapatinib 0.6547184 0.9878187 0.6547 NA NA
CTCF lapatinib 0.6732294 0.9878187 0.6732 NA NA
STAT3 lapatinib 0.6790984 0.9878187 0.6791 NA NA
ESR1 lapatinib 0.6823352 0.9878187 0.6823 NA NA
RAD21 lapatinib 0.6950648 0.9878187 0.6951 NA NA
IKZF1 lapatinib 0.7149708 0.9878187 0.7150 NA NA
ASXL1 lapatinib 0.7456852 0.9878187 0.7457 NA NA
MAP2K1 lapatinib 0.7574056 0.9878187 0.7574 NA NA
AKT2 lapatinib 0.7662055 0.9878187 0.7662 NA NA
PDGFRA lapatinib 0.7718304 0.9878187 0.7718 NA NA
EGF lapatinib 0.7810119 0.9878187 0.7810 NA NA
WHSC1 lapatinib 0.7912577 0.9878187 0.7913 NA NA
SF1 lapatinib 0.8001540 0.9878187 0.8002 NA NA
MPL lapatinib 0.8048218 0.9878187 0.8048 NA NA
PIGA lapatinib 0.8104666 0.9878187 0.8105 NA NA
CREBBP lapatinib 0.8151862 0.9878187 0.8152 NA NA
PRPF40B lapatinib 0.8171082 0.9878187 0.8171 NA NA
KMT2A lapatinib 0.8228845 0.9878187 0.8229 NA NA
FGFR1 lapatinib 0.8287747 0.9878187 0.8288 NA NA
CSF3R lapatinib 0.8590618 0.9878187 0.8591 NA NA
U2AF1 lapatinib 0.8687945 0.9878187 0.8688 NA NA
DNMT3A lapatinib 0.8744953 0.9878187 0.8745 NA NA
STAG2 lapatinib 0.8799391 0.9878187 0.8799 NA NA
WT1 lapatinib 0.8836758 0.9878187 0.8837 NA NA
JAK1 lapatinib 0.8879653 0.9878187 0.8880 NA NA
BTK lapatinib 0.8911322 0.9878187 0.8911 NA NA
PTEN lapatinib 0.8993258 0.9878187 0.8993 NA NA
CDKN2A lapatinib 0.9091620 0.9878187 0.9092 NA NA
EML4 lapatinib 0.9110932 0.9878187 0.9111 NA NA
BRCA1 lapatinib 0.9142372 0.9878187 0.9142 NA NA
JAK2 lapatinib 0.9210478 0.9878187 0.9210 NA NA
PRPF8 lapatinib 0.9234249 0.9878187 0.9234 NA NA
ROS1 lapatinib 0.9246091 0.9878187 0.9246 NA NA
MYD88 lapatinib 0.9323054 0.9878187 0.9323 NA NA
IL7R lapatinib 0.9384466 0.9878187 0.9384 NA NA
BCOR lapatinib 0.9510755 0.9878187 0.9511 NA NA
BRAF lapatinib 0.9579143 0.9878187 0.9579 NA NA
XPO1 lapatinib 0.9630445 0.9878187 0.9630 NA NA
NT5C2 lapatinib 0.9661181 0.9878187 0.9661 NA NA
G6PD lapatinib 0.9681165 0.9878187 0.9681 NA NA
PML lapatinib 0.9738117 0.9878187 0.9738 NA NA
PIK3CA lapatinib 0.9866347 0.9878187 0.9866 NA NA
PTCH1 lapatinib 0.9878187 0.9878187 0.9878 NA NA
JAK3 bosutinib monohydrate 0.4728655 0.9889279 0.4729 NA NA
BCOR bosutinib monohydrate 0.4792497 0.9889279 0.4792 NA NA
ALK vismodegib 0.6657344 0.9892602 0.6657 NA NA
JAK3 vismodegib 0.6747353 0.9892602 0.6747 NA NA
PAX8 vismodegib 0.6926534 0.9892602 0.6927 NA NA
ROS1 vismodegib 0.7075936 0.9892602 0.7076 NA NA
FGFR1 vismodegib 0.7176988 0.9892602 0.7177 NA NA
PTCH1 vismodegib 0.7198241 0.9892602 0.7198 NA NA
FLCN vismodegib 0.7262828 0.9892602 0.7263 NA NA
PHF6 vismodegib 0.7268066 0.9892602 0.7268 NA NA
MDM2 vismodegib 0.7273768 0.9892602 0.7274 NA NA
CXCR4 vismodegib 0.7331174 0.9892602 0.7331 NA NA
PIK3CA vismodegib 0.7343535 0.9892602 0.7344 NA NA
CALR vismodegib 0.7414134 0.9892602 0.7414 NA NA
MYCN vismodegib 0.7563157 0.9892602 0.7563 NA NA
ERBB2 vismodegib 0.7739594 0.9892602 0.7740 NA NA
CDKN2A vismodegib 0.7751324 0.9892602 0.7751 NA NA
EGF vismodegib 0.7936091 0.9892602 0.7936 NA NA
AKT2 vismodegib 0.7962512 0.9892602 0.7963 NA NA
NPM1 vismodegib 0.8004491 0.9892602 0.8004 NA NA
PTPN11 vismodegib 0.8117817 0.9892602 0.8118 NA NA
IL7R vismodegib 0.8119458 0.9892602 0.8119 NA NA
SETBP1 vismodegib 0.8431988 0.9892602 0.8432 NA NA
DDIT3 vismodegib 0.8486410 0.9892602 0.8486 NA NA
CRLF2 vismodegib 0.8514764 0.9892602 0.8515 NA NA
FGFR2 vismodegib 0.8556611 0.9892602 0.8557 NA NA
GNB1 vismodegib 0.8642884 0.9892602 0.8643 NA NA
UGT1A1 vismodegib 0.8657073 0.9892602 0.8657 NA NA
ERBB3 vismodegib 0.8804120 0.9892602 0.8804 NA NA
SMO vismodegib 0.8914996 0.9892602 0.8915 NA NA
U2AF1 vismodegib 0.9095190 0.9892602 0.9095 NA NA
ASXL1 vismodegib 0.9095642 0.9892602 0.9096 NA NA
CREBBP vismodegib 0.9238700 0.9892602 0.9239 NA NA
AKT3 vismodegib 0.9378898 0.9892602 0.9379 NA NA
MGMT vismodegib 0.9400649 0.9892602 0.9401 NA NA
SSX1 vismodegib 0.9409047 0.9892602 0.9409 NA NA
EGFR vismodegib 0.9448114 0.9892602 0.9448 NA NA
ABL1 vismodegib 0.9494533 0.9892602 0.9495 NA NA
CD79B vismodegib 0.9553598 0.9892602 0.9554 NA NA
SF1 vismodegib 0.9658373 0.9892602 0.9658 NA NA
BCORL1 vismodegib 0.9665371 0.9892602 0.9665 NA NA
CYP19A1 vismodegib 0.9723531 0.9892602 0.9724 NA NA
BRCA2 vismodegib 0.9733078 0.9892602 0.9733 NA NA
PIGA vismodegib 0.9761297 0.9892602 0.9761 NA NA
FLT3 vismodegib 0.9773105 0.9892602 0.9773 NA NA
PRPF40B vismodegib 0.9793061 0.9892602 0.9793 NA NA
CTNNB1 vismodegib 0.9841264 0.9892602 0.9841 NA NA
DNAJB1 vismodegib 0.9892602 0.9892602 0.9893 NA NA
MDM2 dasatinib 0.9723856 0.9894450 0.972 NA NA
SSX1 nilotinib 0.9563025 0.9907003 0.9563 NA NA
ASXL1 nilotinib 0.9628343 0.9907003 0.9628 NA NA
DPYD nilotinib 0.9678380 0.9907003 0.9678 NA NA
CBLB afatinib 0.9770926 0.9923597 0.9771 NA NA
MET alectinib 0.8262519 0.9927405 0.8263 NA NA
CDK4 alectinib 0.8384108 0.9927405 0.8384 NA NA
CBL alectinib 0.8404483 0.9927405 0.8404 NA NA
PRPF40B alectinib 0.8649658 0.9927405 0.8650 NA NA
CXCR4 alectinib 0.8726340 0.9927405 0.8726 NA NA
CDC73 alectinib 0.8729260 0.9927405 0.8729 NA NA
FGFR3 alectinib 0.8924433 0.9927405 0.8924 NA NA
BCOR alectinib 0.8960633 0.9927405 0.8961 NA NA
CRLF2 alectinib 0.9059455 0.9927405 0.9059 NA NA
PRPF8 alectinib 0.9120043 0.9927405 0.9120 NA NA
SH2B3 alectinib 0.9243076 0.9927405 0.9243 NA NA
CREBBP alectinib 0.9297312 0.9927405 0.9297 NA NA
MYCN alectinib 0.9314131 0.9927405 0.9314 NA NA
IDH1 alectinib 0.9344033 0.9927405 0.9344 NA NA
CALR alectinib 0.9372021 0.9927405 0.9372 NA NA
NCOA2 alectinib 0.9388572 0.9927405 0.9389 NA NA
IDH2 alectinib 0.9437117 0.9927405 0.9437 NA NA
CSF3R alectinib 0.9447105 0.9927405 0.9447 NA NA
SRSF2 alectinib 0.9507839 0.9927405 0.9508 NA NA
KIT alectinib 0.9692528 0.9927405 0.9693 NA NA
WHSC1 alectinib 0.9757368 0.9927405 0.9757 NA NA
NRAS alectinib 0.9762797 0.9927405 0.9763 NA NA
KRAS alectinib 0.9838427 0.9927405 0.9838 NA NA
ESR1 alectinib 0.9851623 0.9927405 0.9852 NA NA
PAX8 midostaurin 0.9789346 0.9941119 0.9789 NA NA
ETV6 sunitinib 0.9847737 0.9944188 0.985 NA NA
CTCF sunitinib 0.9858463 0.9944188 0.986 NA NA
MGMT ruxolitinib 0.9946721 0.9946721 0.9947 NA NA
BCOR crizotinib 0.9890817 0.9948625 0.9891 NA NA
FBXW7 crizotinib 0.9940455 0.9948625 0.9940 NA NA
PHF6 crizotinib 0.9948625 0.9948625 0.9949 NA NA
EZH2 dabrafenib 0.8492920 0.9949724 0.84929 NA NA
BTK dabrafenib 0.8535378 0.9949724 0.85354 NA NA
PRPF40B dabrafenib 0.8607282 0.9949724 0.86073 NA NA
RIT1 dabrafenib 0.8669500 0.9949724 0.86695 NA NA
PAX5 dabrafenib 0.8814339 0.9949724 0.88143 NA NA
MYCN dabrafenib 0.8835841 0.9949724 0.88358 NA NA
GATA3 dabrafenib 0.9004044 0.9949724 0.90040 NA NA
CYP19A1 dabrafenib 0.9107211 0.9949724 0.91072 NA NA
FGFR1 dabrafenib 0.9151888 0.9949724 0.91519 NA NA
BRCA2 dabrafenib 0.9168207 0.9949724 0.91682 NA NA
GATA2 dabrafenib 0.9389490 0.9949724 0.93895 NA NA
PIGA dabrafenib 0.9436553 0.9949724 0.94366 NA NA
AR dabrafenib 0.9681760 0.9949724 0.96818 NA NA
IDH2 dabrafenib 0.9684328 0.9949724 0.96843 NA NA
FANCL dabrafenib 0.9732873 0.9949724 0.97329 NA NA
SMC3 dabrafenib 0.9734466 0.9949724 0.97345 NA NA
AKT2 dabrafenib 0.9755082 0.9949724 0.97551 NA NA
MYD88 dabrafenib 0.9773916 0.9949724 0.97739 NA NA
WHSC1 dabrafenib 0.9865696 0.9949724 0.98657 NA NA
FGFR2 dabrafenib 0.9883831 0.9949724 0.98838 NA NA
ROS1 dabrafenib 0.9949724 0.9949724 0.99497 NA NA
SMO alectinib 0.9950076 0.9950076 0.9950 NA NA
GNB1 midostaurin 0.9890693 0.9959831 0.9891 NA NA
CDKN2A midostaurin 0.9959831 0.9959831 0.9960 NA NA
PTEN dasatinib 0.9918913 0.9962487 0.992 NA NA
ZRSR2 dasatinib 0.9962487 0.9962487 0.996 NA NA
PAX8 sunitinib 0.9962773 0.9962773 0.996 NA NA
IDH2 palbociclib 0.9443484 0.9964898 0.9443 NA NA
PAX5 palbociclib 0.9597535 0.9964898 0.9598 NA NA
FBXW7 palbociclib 0.9637857 0.9964898 0.9638 NA NA
BCOR palbociclib 0.9763682 0.9964898 0.9764 NA NA
AKT2 palbociclib 0.9809077 0.9964898 0.9809 NA NA
CTCF palbociclib 0.9812762 0.9964898 0.9813 NA NA
KMT2A tretinoin 0.9867957 0.9968006 0.9868 NA NA
FGFR2 tretinoin 0.9899834 0.9968006 0.9900 NA NA
ABL1 tretinoin 0.9968006 0.9968006 0.9968 NA NA
ATM palbociclib 0.9892046 0.9968139 0.9892 NA NA
NT5C2 belinostat 0.3123377 0.9969037 0.31234 NA NA
KRAS belinostat 0.3158051 0.9969037 0.31581 NA NA
CYP19A1 belinostat 0.3161498 0.9969037 0.31615 NA NA
PIGA belinostat 0.3336508 0.9969037 0.33365 NA NA
GNB1 belinostat 0.3441703 0.9969037 0.34417 NA NA
CTCF belinostat 0.3467750 0.9969037 0.34678 NA NA
EZH2 belinostat 0.3495023 0.9969037 0.34950 NA NA
BRCA2 belinostat 0.3501637 0.9969037 0.35016 NA NA
IL7R belinostat 0.3785808 0.9969037 0.37858 NA NA
ERBB3 belinostat 0.3891061 0.9969037 0.38911 NA NA
DDIT3 belinostat 0.3972274 0.9969037 0.39723 NA NA
UGT1A1 belinostat 0.4041103 0.9969037 0.40411 NA NA
PIK3CA belinostat 0.4072121 0.9969037 0.40721 NA NA
SMC3 belinostat 0.4229260 0.9969037 0.42293 NA NA
PRPF40B belinostat 0.4230525 0.9969037 0.42305 NA NA
JAK2 belinostat 0.4239919 0.9969037 0.42399 NA NA
ASXL1 belinostat 0.4246638 0.9969037 0.42466 NA NA
CRLF2 belinostat 0.4451357 0.9969037 0.44514 NA NA
ERBB4 belinostat 0.4469217 0.9969037 0.44692 NA NA
FGFR2 belinostat 0.4626400 0.9969037 0.46264 NA NA
FGFR1 belinostat 0.4651801 0.9969037 0.46518 NA NA
BRCA1 belinostat 0.4653768 0.9969037 0.46538 NA NA
CDC73 belinostat 0.4780499 0.9969037 0.47805 NA NA
G6PD belinostat 0.4798818 0.9969037 0.47988 NA NA
WT1 belinostat 0.4865711 0.9969037 0.48657 NA NA
STAT3 belinostat 0.5022511 0.9969037 0.50225 NA NA
CDKN2A belinostat 0.5154714 0.9969037 0.51547 NA NA
MPL belinostat 0.5173049 0.9969037 0.51730 NA NA
GATA2 belinostat 0.5271314 0.9969037 0.52713 NA NA
CD79B belinostat 0.5522460 0.9969037 0.55225 NA NA
AKT1 belinostat 0.5547454 0.9969037 0.55475 NA NA
ZRSR2 belinostat 0.5551241 0.9969037 0.55512 NA NA
RUNX1 belinostat 0.5560288 0.9969037 0.55603 NA NA
PAX8 belinostat 0.5590195 0.9969037 0.55902 NA NA
MGMT belinostat 0.5789471 0.9969037 0.57895 NA NA
GNA11 belinostat 0.5851873 0.9969037 0.58519 NA NA
NOTCH2 belinostat 0.5876845 0.9969037 0.58768 NA NA
FLCN belinostat 0.5905635 0.9969037 0.59056 NA NA
WHSC1 belinostat 0.5965935 0.9969037 0.59659 NA NA
CBLB belinostat 0.6024277 0.9969037 0.60243 NA NA
SRSF2 belinostat 0.6119949 0.9969037 0.61199 NA NA
PRPF8 belinostat 0.6148581 0.9969037 0.61486 NA NA
PDGFB belinostat 0.6267736 0.9969037 0.62677 NA NA
CEBPA belinostat 0.6359932 0.9969037 0.63599 NA NA
GATA3 belinostat 0.6548206 0.9969037 0.65482 NA NA
FLT3 belinostat 0.6686147 0.9969037 0.66861 NA NA
JAK1 belinostat 0.6717499 0.9969037 0.67175 NA NA
CXCR4 belinostat 0.6735809 0.9969037 0.67358 NA NA
PDCD1 belinostat 0.6759501 0.9969037 0.67595 NA NA
EGFR belinostat 0.6783585 0.9969037 0.67836 NA NA
SF3B1 belinostat 0.6860819 0.9969037 0.68608 NA NA
RET belinostat 0.6890334 0.9969037 0.68903 NA NA
GATA1 belinostat 0.7010507 0.9969037 0.70105 NA NA
TET2 belinostat 0.7026106 0.9969037 0.70261 NA NA
TSC2 belinostat 0.7089749 0.9969037 0.70897 NA NA
AR belinostat 0.7191374 0.9969037 0.71914 NA NA
CDK4 belinostat 0.7399640 0.9969037 0.73996 NA NA
PDGFRA belinostat 0.7450686 0.9969037 0.74507 NA NA
PML belinostat 0.7463779 0.9969037 0.74638 NA NA
NOTCH1 belinostat 0.7507540 0.9969037 0.75075 NA NA
CREBBP belinostat 0.7547871 0.9969037 0.75479 NA NA
SSX1 belinostat 0.7759031 0.9969037 0.77590 NA NA
CTLA4 belinostat 0.7879627 0.9969037 0.78796 NA NA
AKT2 belinostat 0.7986070 0.9969037 0.79861 NA NA
MYCN belinostat 0.8021438 0.9969037 0.80214 NA NA
DPYD belinostat 0.8079628 0.9969037 0.80796 NA NA
SETD2 belinostat 0.8095851 0.9969037 0.80959 NA NA
IKZF1 belinostat 0.8113724 0.9969037 0.81137 NA NA
MAP2K1 belinostat 0.8327077 0.9969037 0.83271 NA NA
PHF6 belinostat 0.8666835 0.9969037 0.86668 NA NA
SMO belinostat 0.8688884 0.9969037 0.86889 NA NA
AKT3 belinostat 0.8831307 0.9969037 0.88313 NA NA
EML4 belinostat 0.8965070 0.9969037 0.89651 NA NA
TSC1 belinostat 0.9061702 0.9969037 0.90617 NA NA
ATM belinostat 0.9231828 0.9969037 0.92318 NA NA
CTNNB1 belinostat 0.9260261 0.9969037 0.92603 NA NA
CALR belinostat 0.9275787 0.9969037 0.92758 NA NA
FBXW7 belinostat 0.9290017 0.9969037 0.92900 NA NA
KIT belinostat 0.9303304 0.9969037 0.93033 NA NA
PAX5 belinostat 0.9366113 0.9969037 0.93661 NA NA
CDK6 belinostat 0.9369710 0.9969037 0.93697 NA NA
MDM2 belinostat 0.9372150 0.9969037 0.93721 NA NA
RPL10 belinostat 0.9410297 0.9969037 0.94103 NA NA
CSF3R belinostat 0.9429053 0.9969037 0.94291 NA NA
RAD21 belinostat 0.9463328 0.9969037 0.94633 NA NA
ETV6 belinostat 0.9514347 0.9969037 0.95143 NA NA
FANCL belinostat 0.9517795 0.9969037 0.95178 NA NA
SMC1A belinostat 0.9581409 0.9969037 0.95814 NA NA
BTK belinostat 0.9628687 0.9969037 0.96287 NA NA
GNAS belinostat 0.9662777 0.9969037 0.96628 NA NA
DNMT3A belinostat 0.9723117 0.9969037 0.97231 NA NA
U2AF1 belinostat 0.9762326 0.9969037 0.97623 NA NA
EED belinostat 0.9816838 0.9969037 0.98168 NA NA
CTCF ponatinib 0.3280080 0.9972326 0.328 NA NA
GNB1 ponatinib 0.3304650 0.9972326 0.330 NA NA
NRAS ponatinib 0.3414906 0.9972326 0.341 NA NA
G6PD ponatinib 0.3562978 0.9972326 0.356 NA NA
AKT3 ponatinib 0.3621735 0.9972326 0.362 NA NA
MDM2 ponatinib 0.3814458 0.9972326 0.381 NA NA
SETBP1 ponatinib 0.3902213 0.9972326 0.390 NA NA
RUNX1 ponatinib 0.3986659 0.9972326 0.399 NA NA
DDIT3 ponatinib 0.4091577 0.9972326 0.409 NA NA
WHSC1 ponatinib 0.4135038 0.9972326 0.414 NA NA
EML4 ponatinib 0.4160407 0.9972326 0.416 NA NA
BTK ponatinib 0.4171885 0.9972326 0.417 NA NA
MPL ponatinib 0.4233079 0.9972326 0.423 NA NA
SETD2 ponatinib 0.4289630 0.9972326 0.429 NA NA
BRCA1 ponatinib 0.4319743 0.9972326 0.432 NA NA
CD79B ponatinib 0.4546022 0.9972326 0.455 NA NA
MYCN ponatinib 0.4565739 0.9972326 0.457 NA NA
PAX8 ponatinib 0.4661236 0.9972326 0.466 NA NA
BRCA2 ponatinib 0.4687534 0.9972326 0.469 NA NA
PDGFB ponatinib 0.4821695 0.9972326 0.482 NA NA
IKZF1 ponatinib 0.4960463 0.9972326 0.496 NA NA
HRAS ponatinib 0.5102704 0.9972326 0.510 NA NA
PHF6 ponatinib 0.5333653 0.9972326 0.533 NA NA
SSX1 ponatinib 0.5376169 0.9972326 0.538 NA NA
RAD21 ponatinib 0.5382645 0.9972326 0.538 NA NA
ETV6 ponatinib 0.5414576 0.9972326 0.541 NA NA
SMO ponatinib 0.5427786 0.9972326 0.543 NA NA
MGMT ponatinib 0.5540759 0.9972326 0.554 NA NA
CTNNB1 ponatinib 0.5759382 0.9972326 0.576 NA NA
JAK3 ponatinib 0.5765409 0.9972326 0.577 NA NA
RET ponatinib 0.5838741 0.9972326 0.584 NA NA
NPM1 ponatinib 0.5854791 0.9972326 0.585 NA NA
EGFR ponatinib 0.5861711 0.9972326 0.586 NA NA
TSC1 ponatinib 0.6125905 0.9972326 0.613 NA NA
MET ponatinib 0.6159349 0.9972326 0.616 NA NA
PML ponatinib 0.6178115 0.9972326 0.618 NA NA
SF1 ponatinib 0.6198294 0.9972326 0.620 NA NA
ZRSR2 ponatinib 0.6253285 0.9972326 0.625 NA NA
DNMT3A ponatinib 0.6448404 0.9972326 0.645 NA NA
XPO1 ponatinib 0.6457762 0.9972326 0.646 NA NA
CD274 ponatinib 0.6479420 0.9972326 0.648 NA NA
FLT3 ponatinib 0.6691061 0.9972326 0.669 NA NA
IDH1 ponatinib 0.6713059 0.9972326 0.671 NA NA
PDGFRA ponatinib 0.6831311 0.9972326 0.683 NA NA
GATA3 ponatinib 0.6899584 0.9972326 0.690 NA NA
UGT1A1 ponatinib 0.7062488 0.9972326 0.706 NA NA
WT1 ponatinib 0.7147828 0.9972326 0.715 NA NA
CDK4 ponatinib 0.7179383 0.9972326 0.718 NA NA
PDGFRB ponatinib 0.7240517 0.9972326 0.724 NA NA
GATA2 ponatinib 0.7335798 0.9972326 0.734 NA NA
FLCN ponatinib 0.7349618 0.9972326 0.735 NA NA
CBL ponatinib 0.7373495 0.9972326 0.737 NA NA
PRPF40B ponatinib 0.7385033 0.9972326 0.739 NA NA
CYP19A1 ponatinib 0.7421820 0.9972326 0.742 NA NA
NT5C2 ponatinib 0.7573545 0.9972326 0.757 NA NA
FGFR3 ponatinib 0.7753615 0.9972326 0.775 NA NA
CBLB ponatinib 0.7877705 0.9972326 0.788 NA NA
BRAF ponatinib 0.7903167 0.9972326 0.790 NA NA
NOTCH2 ponatinib 0.8034028 0.9972326 0.803 NA NA
VHL ponatinib 0.8280799 0.9972326 0.828 NA NA
NCOA2 ponatinib 0.8286775 0.9972326 0.829 NA NA
STAG2 ponatinib 0.8454770 0.9972326 0.845 NA NA
MAP2K1 ponatinib 0.8469335 0.9972326 0.847 NA NA
FGFR1 ponatinib 0.8480615 0.9972326 0.848 NA NA
SF3B1 ponatinib 0.8491288 0.9972326 0.849 NA NA
MYD88 ponatinib 0.8552763 0.9972326 0.855 NA NA
ERBB4 ponatinib 0.8558847 0.9972326 0.856 NA NA
ESR1 ponatinib 0.8695576 0.9972326 0.870 NA NA
PDCD1 ponatinib 0.8703157 0.9972326 0.870 NA NA
KMT2A ponatinib 0.8723076 0.9972326 0.872 NA NA
TPMT ponatinib 0.8811769 0.9972326 0.881 NA NA
CEBPA ponatinib 0.8994044 0.9972326 0.899 NA NA
GATA1 ponatinib 0.9103985 0.9972326 0.910 NA NA
SMC3 ponatinib 0.9106175 0.9972326 0.911 NA NA
ERBB2 ponatinib 0.9158815 0.9972326 0.916 NA NA
PIK3CA ponatinib 0.9215126 0.9972326 0.922 NA NA
PRPF8 ponatinib 0.9216621 0.9972326 0.922 NA NA
NOTCH1 ponatinib 0.9235323 0.9972326 0.924 NA NA
KIT ponatinib 0.9257639 0.9972326 0.926 NA NA
GNAQ ponatinib 0.9286811 0.9972326 0.929 NA NA
MAP2K2 ponatinib 0.9308325 0.9972326 0.931 NA NA
CRLF2 ponatinib 0.9548438 0.9972326 0.955 NA NA
ALK ponatinib 0.9561548 0.9972326 0.956 NA NA
SMC1A ponatinib 0.9617697 0.9972326 0.962 NA NA
BCOR ponatinib 0.9670462 0.9972326 0.967 NA NA
AR ponatinib 0.9737798 0.9972326 0.974 NA NA
PAX5 ponatinib 0.9765095 0.9972326 0.977 NA NA
JAK2 ponatinib 0.9882767 0.9972326 0.988 NA NA
EED ponatinib 0.9938213 0.9972326 0.994 NA NA
AKT1 ponatinib 0.9972326 0.9972326 0.997 NA NA
SH2B3 belinostat 0.9899582 0.9975732 0.98996 NA NA
PHF6 palbociclib 0.9984149 0.9984149 0.9984 NA NA
KMT2A bosutinib monohydrate 0.4965364 0.9984574 0.4965 NA NA
NOTCH2 bosutinib monohydrate 0.5054644 0.9984574 0.5055 NA NA
SMC3 bosutinib monohydrate 0.5290075 0.9984574 0.5290 NA NA
CTCF bosutinib monohydrate 0.5335475 0.9984574 0.5335 NA NA
RET bosutinib monohydrate 0.5509591 0.9984574 0.5510 NA NA
IKZF1 bosutinib monohydrate 0.5599796 0.9984574 0.5600 NA NA
CD79B bosutinib monohydrate 0.5670616 0.9984574 0.5671 NA NA
AKT3 bosutinib monohydrate 0.5766764 0.9984574 0.5767 NA NA
AKT2 bosutinib monohydrate 0.6027318 0.9984574 0.6027 NA NA
SETBP1 bosutinib monohydrate 0.6114437 0.9984574 0.6114 NA NA
MGMT bosutinib monohydrate 0.6222029 0.9984574 0.6222 NA NA
TSC2 bosutinib monohydrate 0.6543872 0.9984574 0.6544 NA NA
CBL bosutinib monohydrate 0.6620191 0.9984574 0.6620 NA NA
PRPF40B bosutinib monohydrate 0.6722945 0.9984574 0.6723 NA NA
NT5C2 bosutinib monohydrate 0.6791919 0.9984574 0.6792 NA NA
PHF6 bosutinib monohydrate 0.6899414 0.9984574 0.6899 NA NA
CYP19A1 bosutinib monohydrate 0.6902719 0.9984574 0.6903 NA NA
CD274 bosutinib monohydrate 0.6927838 0.9984574 0.6928 NA NA
PTEN bosutinib monohydrate 0.6935476 0.9984574 0.6935 NA NA
PRPF8 bosutinib monohydrate 0.7291900 0.9984574 0.7292 NA NA
KRAS bosutinib monohydrate 0.7414809 0.9984574 0.7415 NA NA
PDGFRB bosutinib monohydrate 0.7429860 0.9984574 0.7430 NA NA
FANCL bosutinib monohydrate 0.7442638 0.9984574 0.7443 NA NA
SMO bosutinib monohydrate 0.7478513 0.9984574 0.7479 NA NA
DNMT3A bosutinib monohydrate 0.7551741 0.9984574 0.7552 NA NA
FGFR1 bosutinib monohydrate 0.7589059 0.9984574 0.7589 NA NA
PDGFB bosutinib monohydrate 0.7637526 0.9984574 0.7638 NA NA
IDH1 bosutinib monohydrate 0.7658117 0.9984574 0.7658 NA NA
ETV6 bosutinib monohydrate 0.7705523 0.9984574 0.7706 NA NA
ABL1 bosutinib monohydrate 0.7708229 0.9984574 0.7708 NA NA
WHSC1 bosutinib monohydrate 0.7917104 0.9984574 0.7917 NA NA
JAK1 bosutinib monohydrate 0.7934737 0.9984574 0.7935 NA NA
CDK6 bosutinib monohydrate 0.7961993 0.9984574 0.7962 NA NA
SSX1 bosutinib monohydrate 0.8010644 0.9984574 0.8011 NA NA
ERBB4 bosutinib monohydrate 0.8029349 0.9984574 0.8029 NA NA
STAT3 bosutinib monohydrate 0.8055766 0.9984574 0.8056 NA NA
ESR1 bosutinib monohydrate 0.8080005 0.9984574 0.8080 NA NA
CREBBP bosutinib monohydrate 0.8213056 0.9984574 0.8213 NA NA
SRSF2 bosutinib monohydrate 0.8216022 0.9984574 0.8216 NA NA
EGFR bosutinib monohydrate 0.8249647 0.9984574 0.8250 NA NA
GNA11 bosutinib monohydrate 0.8354619 0.9984574 0.8355 NA NA
FGFR3 bosutinib monohydrate 0.8529747 0.9984574 0.8530 NA NA
CSF3R bosutinib monohydrate 0.8534255 0.9984574 0.8534 NA NA
FLT3 bosutinib monohydrate 0.8695733 0.9984574 0.8696 NA NA
PIK3CA bosutinib monohydrate 0.8814447 0.9984574 0.8814 NA NA
ATM bosutinib monohydrate 0.8890563 0.9984574 0.8891 NA NA
MYD88 bosutinib monohydrate 0.8892270 0.9984574 0.8892 NA NA
PIGA bosutinib monohydrate 0.8899516 0.9984574 0.8900 NA NA
MYCN bosutinib monohydrate 0.8946713 0.9984574 0.8947 NA NA
AR bosutinib monohydrate 0.8991314 0.9984574 0.8991 NA NA
ALK bosutinib monohydrate 0.9008561 0.9984574 0.9009 NA NA
WT1 bosutinib monohydrate 0.9087099 0.9984574 0.9087 NA NA
HRAS bosutinib monohydrate 0.9249674 0.9984574 0.9250 NA NA
CALR bosutinib monohydrate 0.9357151 0.9984574 0.9357 NA NA
CDK4 bosutinib monohydrate 0.9416541 0.9984574 0.9417 NA NA
FBXW7 bosutinib monohydrate 0.9426717 0.9984574 0.9427 NA NA
TP53 bosutinib monohydrate 0.9456282 0.9984574 0.9456 NA NA
NCOA2 bosutinib monohydrate 0.9552949 0.9984574 0.9553 NA NA
NRAS bosutinib monohydrate 0.9617340 0.9984574 0.9617 NA NA
RUNX1 bosutinib monohydrate 0.9702483 0.9984574 0.9702 NA NA
CRLF2 bosutinib monohydrate 0.9769377 0.9984574 0.9769 NA NA
TPMT bosutinib monohydrate 0.9847665 0.9984574 0.9848 NA NA
FGFR2 bosutinib monohydrate 0.9892432 0.9984574 0.9892 NA NA
FLCN bosutinib monohydrate 0.9945924 0.9984574 0.9946 NA NA
DDIT3 bosutinib monohydrate 0.9949740 0.9984574 0.9950 NA NA
GATA3 bosutinib monohydrate 0.9960502 0.9984574 0.9961 NA NA
JAK2 bosutinib monohydrate 0.9984574 0.9984574 0.9985 NA NA
MYCN nilotinib 0.9867686 0.9988803 0.9868 NA NA
ALK nilotinib 0.9911966 0.9988803 0.9912 NA NA
ETV6 afatinib 0.9917220 0.9994098 0.9917 NA NA
DNMT3A pazopanib 0.9995159 0.9995159 0.9995 NA NA
NOTCH2 docetaxel 1.0000000 1.0000000 1.00000 NA NA
FGFR3 nilotinib 1.0000000 1.0000000 1.0000 NA NA
IDH1 belinostat 1.0000000 1.0000000 1.00000 NA NA
CTLA4 rucaparib 0.9111547 1.0000000 0.911 NA NA
SETBP1 rucaparib 0.9349068 1.0000000 0.935 NA NA
FLCN rucaparib 0.9396675 1.0000000 0.940 NA NA
ERBB4 rucaparib 0.9452339 1.0000000 0.945 NA NA
CRLF2 rucaparib 0.9477501 1.0000000 0.948 NA NA
IKZF1 rucaparib 0.9570156 1.0000000 0.957 NA NA
BCORL1 rucaparib 0.9589124 1.0000000 0.959 NA NA
SF1 rucaparib 0.9651374 1.0000000 0.965 NA NA
PDCD1 rucaparib 0.9729859 1.0000000 0.973 NA NA
SH2B3 rucaparib 0.9811815 1.0000000 0.981 NA NA
WT1 rucaparib 0.9967317 1.0000000 0.997 NA NA
DNAJB1 rucaparib 0.9975452 1.0000000 0.998 NA NA
CREBBP rucaparib 0.9980993 1.0000000 0.998 NA NA
EGF rucaparib 1.0000000 1.0000000 1.000 NA NA
PHF6 afatinib 1.0000000 1.0000000 1.0000 NA NA
ASXL1 imatinib 0.8389707 1.0000000 0.839 NA NA
JAK2 imatinib 0.8521878 1.0000000 0.852 NA NA
CDK4 imatinib 0.8774107 1.0000000 0.877 NA NA
RUNX1 imatinib 0.8807874 1.0000000 0.881 NA NA
AKT2 imatinib 0.9023418 1.0000000 0.902 NA NA
NOTCH2 imatinib 0.9152305 1.0000000 0.915 NA NA
ROS1 imatinib 0.9157097 1.0000000 0.916 NA NA
SETBP1 imatinib 0.9231968 1.0000000 0.923 NA NA
PTEN imatinib 0.9311434 1.0000000 0.931 NA NA
PAX8 imatinib 0.9384184 1.0000000 0.938 NA NA
CXCR4 imatinib 0.9466483 1.0000000 0.947 NA NA
MPL imatinib 0.9466483 1.0000000 0.947 NA NA
ALK imatinib 0.9639389 1.0000000 0.964 NA NA
CRLF2 imatinib 0.9673747 1.0000000 0.967 NA NA
FBXW7 imatinib 0.9792390 1.0000000 0.979 NA NA
PIK3CA imatinib 0.9871324 1.0000000 0.987 NA NA
PTCH1 imatinib 0.9882665 1.0000000 0.988 NA NA
CBLB imatinib 0.9907752 1.0000000 0.991 NA NA
JAK1 imatinib 0.9944990 1.0000000 0.994 NA NA
MGMT imatinib 1.0000000 1.0000000 1.000 NA NA
BCORL1 erlotinib 1.0000000 1.0000000 1.0000 NA NA 
wilcox_ctrp_gene_lvlA_plot <- ggplot(data = ctrp_signif_lvlA) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_ctrp_gene_lvlA_plot

5.2.5 GDSC: Gene and drug

gdsc_data_ptmuts <- filter(gdsc_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
gdsc_data_ptmuts$Keep_PtMut_Tests <- ifelse(gdsc_data_ptmuts$Reference_Allele_Length == 1 | is.na(gdsc_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(gdsc_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
gdsc_data_ptmuts <- filter(gdsc_data_ptmuts, Keep_PtMut_Tests == TRUE)
gdsc_data_lvlA <- filter(gdsc_data_ptmuts, Hugo_Symbol %in% genes_lvlA)
gdsc_signif_lvlA_ByDrug <- lapply(unique(gdsc_data_lvlA$Drug), WilcoxonByDrug, dataset = gdsc_data_lvlA, data_name = "GDSC")
names(gdsc_signif_lvlA_ByDrug) <- unique(gdsc_data_lvlA$Drug)
saveRDS(gdsc_signif_lvlA_ByDrug, "./data_munging/rds/gdsc_signif_lvlA_ByDrug.rds")

gdsc_signif_lvlA <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = c("Drug", "Hugo_Symbol"), data = gdsc_data_lvlA, method = "wilcox.test", p.adjust.method = "BH")
gdsc_signif_lvlA <- adj_signif(gdsc_signif_lvlA)
gdsc_signif_lvlA <- gdsc_signif_lvlA[order(gdsc_signif_lvlA$p),]
saveRDS(gdsc_signif_lvlA, "./data_munging/rds/gdsc_signif_lvlA_gene.rds")
gdsc_signif_lvlA <- readRDS("./data_munging/rds/gdsc_signif_lvlA_gene.rds")

knitr::kable(gdsc_signif_lvlA[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
GDSC: Wilcoxon test results for Level A point mutations, p < 0.01 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
KRAS trametinib 0.0000000 0.0000271 8.5e-09 **** ****
BRAF dabrafenib 0.0001234 0.1668572 0.00012 *** NA
BRAF trametinib 0.0001576 0.1668572 0.00016 *** NA
PTEN belinostat 0.0002105 0.1671060 0.00021 *** NA
BCORL1 temozolomide 0.0003147 0.1999131 0.00031 *** NA
CDKN2A trametinib 0.0003927 0.1999225 0.00039 *** NA
TP53 docetaxel 0.0004703 0.1999225 0.00047 *** NA
PDGFRB cabozantinib 0.0005036 0.1999225 0.00050 *** NA
CDKN2A docetaxel 0.0006721 0.2371813 0.00067 *** NA
EZH2 bosutinib monohydrate 0.0011913 0.3783489 0.00119 ** NA
KRAS palbociclib 0.0017081 0.4931890 0.00171 ** NA
VHL gefitinib 0.0020451 0.5412812 0.00205 ** NA
PIK3CA docetaxel 0.0023604 0.5766680 0.00236 ** NA
PDGFRB tretinoin 0.0032063 0.6922884 0.00321 ** NA
XPO1 tretinoin 0.0033296 0.6922884 0.00333 ** NA
GNB1 ruxolitinib 0.0035419 0.6922884 0.00354 ** NA
ROS1 cabozantinib 0.0037056 0.6922884 0.00371 ** NA
NRAS imatinib 0.0040262 0.6929219 0.00403 ** NA
GNB1 alectinib 0.0042631 0.6929219 0.00426 ** NA
KRAS pazopanib 0.0043870 0.6929219 0.00439 ** NA
NCOA2 crizotinib 0.0046821 0.6929219 0.00468 ** NA
NOTCH2 nilotinib 0.0055404 0.6929219 0.00554 ** NA
EGF gefitinib 0.0056307 0.6929219 0.00563 ** NA
NCOA2 temozolomide 0.0057459 0.6929219 0.00575 ** NA
VHL erlotinib 0.0058080 0.6929219 0.00581 ** NA
VHL lapatinib 0.0058885 0.6929219 0.00589 ** NA
BRCA2 midostaurin 0.0058907 0.6929219 0.00589 ** NA
NOTCH1 afatinib 0.0065209 0.7360002 0.00652 ** NA
GNAS temozolomide 0.0072122 0.7360002 0.00721 ** NA
TSC1 temozolomide 0.0073262 0.7360002 0.00733 ** NA
NRAS trametinib 0.0075575 0.7360002 0.00756 ** NA
ABL1 pazopanib 0.0076975 0.7360002 0.00770 ** NA
CDKN2A palbociclib 0.0077157 0.7360002 0.00772 ** NA
VHL afatinib 0.0079992 0.7360002 0.00800 ** NA
CALR dabrafenib 0.0081373 0.7360002 0.00814 ** NA
NOTCH1 gefitinib 0.0083426 0.7360002 0.00834 ** NA
ALK palbociclib 0.0089754 0.7704279 0.00898 ** NA
ETV6 vismodegib 0.0097525 0.7838930 0.00975 ** NA
SETBP1 palbociclib 0.0102198 0.7838930 0.01022
NA
WHSC1 temozolomide 0.0104370 0.7838930 0.01044
NA
ETV6 temozolomide 0.0105755 0.7838930 0.01058
NA
NOTCH2 rucaparib 0.0108793 0.7838930 0.01088
NA
NOTCH2 dabrafenib 0.0122810 0.7838930 0.01228
NA
XPO1 dabrafenib 0.0123840 0.7838930 0.01238
NA
CREBBP palbociclib 0.0129659 0.7838930 0.01297
NA
RAD21 nilotinib 0.0135245 0.7838930 0.01352
NA
TP53 palbociclib 0.0135644 0.7838930 0.01356
NA
SMC3 tretinoin 0.0138983 0.7838930 0.01390
NA
JAK1 temozolomide 0.0139643 0.7838930 0.01396
NA
NOTCH2 tretinoin 0.0152457 0.7838930 0.01525
NA
NOTCH2 gefitinib 0.0154450 0.7838930 0.01545
NA
PTPN11 belinostat 0.0156755 0.7838930 0.01568
NA
EGF afatinib 0.0156979 0.7838930 0.01570
NA
CDK6 pazopanib 0.0157171 0.7838930 0.01572
NA
AKT3 docetaxel 0.0158279 0.7838930 0.01583
NA
ROS1 trametinib 0.0160528 0.7838930 0.01605
NA
ZRSR2 tretinoin 0.0162776 0.7838930 0.01628
NA
DNMT3A temozolomide 0.0163008 0.7838930 0.01630
NA
FGFR3 gefitinib 0.0163800 0.7838930 0.01638
NA
EZH2 imatinib 0.0169779 0.7838930 0.01698
NA
BRCA1 tretinoin 0.0170421 0.7838930 0.01704
NA
PIK3CA afatinib 0.0170969 0.7838930 0.01710
NA
TP53 gefitinib 0.0171497 0.7838930 0.01715
NA
ERBB2 afatinib 0.0171962 0.7838930 0.01720
NA
CTNNB1 ruxolitinib 0.0173719 0.7838930 0.01737
NA
PTEN midostaurin 0.0178005 0.7838930 0.01780
NA
BRAF bosutinib monohydrate 0.0181741 0.7838930 0.01817
NA
EZH2 rucaparib 0.0182099 0.7838930 0.01821
NA
PAX8 ruxolitinib 0.0184880 0.7838930 0.01849
NA
MAP2K1 ruxolitinib 0.0186366 0.7838930 0.01864
NA
KIT bosutinib monohydrate 0.0186703 0.7838930 0.01867
NA
GNB1 lapatinib 0.0188968 0.7838930 0.01890
NA
ABL1 gefitinib 0.0196537 0.7838930 0.01965
NA
XPO1 vismodegib 0.0197148 0.7838930 0.01971
NA
CDK6 trametinib 0.0198135 0.7838930 0.01981
NA
BRCA2 erlotinib 0.0208851 0.7838930 0.02089
NA
DPYD lapatinib 0.0212882 0.7838930 0.02129
NA
TPMT cabozantinib 0.0218657 0.7838930 0.02187
NA
CTNNB1 temozolomide 0.0219771 0.7838930 0.02198
NA
CDC73 ponatinib 0.0223079 0.7838930 0.02231
NA
SF3B1 trametinib 0.0228964 0.7838930 0.02290
NA
RUNX1 docetaxel 0.0229958 0.7838930 0.02300
NA
NRAS afatinib 0.0229960 0.7838930 0.02300
NA
SH2B3 cabozantinib 0.0231792 0.7838930 0.02318
NA
MGMT docetaxel 0.0241785 0.7838930 0.02418
NA
CREBBP midostaurin 0.0242074 0.7838930 0.02421
NA
CTCF temozolomide 0.0242740 0.7838930 0.02427
NA
GNAQ vismodegib 0.0250242 0.7838930 0.02502
NA
DNAJB1 cabozantinib 0.0250495 0.7838930 0.02505
NA
GNB1 imatinib 0.0252224 0.7838930 0.02522
NA
VHL temozolomide 0.0253591 0.7838930 0.02536
NA
EZH2 ruxolitinib 0.0258155 0.7838930 0.02582
NA
AR temozolomide 0.0274000 0.7838930 0.02740
NA
UGT1A1 trametinib 0.0274916 0.7838930 0.02749
NA
KRAS dabrafenib 0.0278924 0.7838930 0.02789
NA
ETV6 nilotinib 0.0280075 0.7838930 0.02801
NA
GNAQ temozolomide 0.0282137 0.7838930 0.02821
NA
AKT3 dabrafenib 0.0282407 0.7838930 0.02824
NA
GATA2 trametinib 0.0282655 0.7838930 0.02827
NA
FLT3 cabozantinib 0.0283979 0.7838930 0.02840
NA
MAP2K1 tretinoin 0.0288016 0.7838930 0.02880
NA
DNAJB1 dabrafenib 0.0289287 0.7838930 0.02893
NA
CALR temozolomide 0.0292063 0.7838930 0.02921
NA
TET2 cabozantinib 0.0296182 0.7838930 0.02962
NA
TSC1 sunitinib 0.0300384 0.7838930 0.03004
NA
GNAQ nilotinib 0.0300494 0.7838930 0.03005
NA
MAP2K2 cabozantinib 0.0302155 0.7838930 0.03022
NA
PIK3CA ruxolitinib 0.0312550 0.7838930 0.03126
NA
GNAQ tretinoin 0.0312954 0.7838930 0.03130
NA
KMT2A cabozantinib 0.0319699 0.7838930 0.03197
NA
EGF midostaurin 0.0320598 0.7838930 0.03206
NA
AR tretinoin 0.0321095 0.7838930 0.03211
NA
MAP2K1 nilotinib 0.0321453 0.7838930 0.03215
NA
IKZF1 temozolomide 0.0321740 0.7838930 0.03217
NA
CDC73 nilotinib 0.0329322 0.7838930 0.03293
NA
EZH2 tretinoin 0.0330076 0.7838930 0.03301
NA
SMC3 lapatinib 0.0337864 0.7838930 0.03379
NA
ZRSR2 cabozantinib 0.0342010 0.7838930 0.03420
NA
IL7R temozolomide 0.0343195 0.7838930 0.03432
NA
ERBB3 ponatinib 0.0344904 0.7838930 0.03449
NA
GNAS midostaurin 0.0345520 0.7838930 0.03455
NA
DNAJB1 trametinib 0.0348374 0.7838930 0.03484
NA
XPO1 temozolomide 0.0353903 0.7838930 0.03539
NA
NPM1 tretinoin 0.0355459 0.7838930 0.03555
NA
CTNNB1 docetaxel 0.0356295 0.7838930 0.03563
NA
EZH2 palbociclib 0.0358492 0.7838930 0.03585
NA
SF3B1 sunitinib 0.0358665 0.7838930 0.03587
NA
JAK2 dabrafenib 0.0362699 0.7838930 0.03627
NA
CDC73 vismodegib 0.0366254 0.7838930 0.03663
NA
FLT3 crizotinib 0.0371049 0.7838930 0.03710
NA
FBXW7 gefitinib 0.0379174 0.7838930 0.03792
NA
PHF6 cabozantinib 0.0380544 0.7838930 0.03805
NA
FANCL tretinoin 0.0383049 0.7838930 0.03830
NA
UGT1A1 afatinib 0.0384529 0.7838930 0.03845
NA
UGT1A1 midostaurin 0.0385592 0.7838930 0.03856
NA
PIGA gefitinib 0.0386253 0.7838930 0.03863
NA
IDH1 nilotinib 0.0386525 0.7838930 0.03865
NA
ERBB3 temozolomide 0.0387034 0.7838930 0.03870
NA
TP53 belinostat 0.0391583 0.7838930 0.03916
NA
ESR1 imatinib 0.0394429 0.7838930 0.03944
NA
TSC1 crizotinib 0.0396633 0.7838930 0.03966
NA
CDKN2A afatinib 0.0397152 0.7838930 0.03972
NA
U2AF1 pazopanib 0.0404444 0.7838930 0.04044
NA
NOTCH2 temozolomide 0.0404672 0.7838930 0.04047
NA
FGFR2 docetaxel 0.0408171 0.7838930 0.04082
NA
NOTCH1 trametinib 0.0408364 0.7838930 0.04084
NA
BRCA2 crizotinib 0.0408902 0.7838930 0.04089
NA
ZRSR2 rucaparib 0.0409566 0.7838930 0.04096
NA
CREBBP sunitinib 0.0413703 0.7838930 0.04137
NA
TSC1 tretinoin 0.0414817 0.7838930 0.04148
NA
MAP2K2 rucaparib 0.0415245 0.7838930 0.04152
NA
SF3B1 gefitinib 0.0415984 0.7838930 0.04160
NA
EZH2 temozolomide 0.0417184 0.7838930 0.04172
NA
NRAS belinostat 0.0419064 0.7838930 0.04191
NA
CDC73 tretinoin 0.0420071 0.7838930 0.04201
NA
GATA2 palbociclib 0.0420214 0.7838930 0.04202
NA
SETBP1 cabozantinib 0.0422020 0.7838930 0.04220
NA
AKT3 trametinib 0.0423852 0.7838930 0.04239
NA
GNAS tretinoin 0.0432305 0.7838930 0.04323
NA
ABL1 cabozantinib 0.0433477 0.7838930 0.04335
NA
CTNNB1 cabozantinib 0.0433564 0.7838930 0.04336
NA
RAD21 alectinib 0.0435161 0.7838930 0.04352
NA
PDCD1 temozolomide 0.0440126 0.7838930 0.04401
NA
CEBPA pazopanib 0.0446243 0.7838930 0.04462
NA
DNAJB1 ponatinib 0.0447942 0.7838930 0.04479
NA
CDK6 sunitinib 0.0453261 0.7838930 0.04533
NA
ATM docetaxel 0.0457127 0.7838930 0.04571
NA
CREBBP docetaxel 0.0462148 0.7838930 0.04621
NA
NCOA2 imatinib 0.0464638 0.7838930 0.04646
NA
SH2B3 bosutinib monohydrate 0.0467380 0.7838930 0.04674
NA
WHSC1 ruxolitinib 0.0467507 0.7838930 0.04675
NA
DNMT3A sunitinib 0.0480660 0.7838930 0.04807
NA
IDH1 trametinib 0.0480714 0.7838930 0.04807
NA
RAD21 ruxolitinib 0.0481399 0.7838930 0.04814
NA
CRLF2 docetaxel 0.0483075 0.7838930 0.04831
NA
ZRSR2 trametinib 0.0485098 0.7838930 0.04851
NA
SSX1 temozolomide 0.0487651 0.7838930 0.04877
NA
EML4 alectinib 0.0492773 0.7838930 0.04928
NA
GATA3 palbociclib 0.0495673 0.7838930 0.04957
NA
RUNX1 dasatinib 0.0499298 0.7838930 0.04993
NA
TPMT temozolomide 0.0503050 0.7838930 0.05030 NA NA
TSC1 rucaparib 0.0503265 0.7838930 0.05033 NA NA
PIK3CA gefitinib 0.0505049 0.7838930 0.05050 NA NA
NPM1 dabrafenib 0.0506987 0.7838930 0.05070 NA NA
ABL1 afatinib 0.0507264 0.7838930 0.05073 NA NA
KIT nilotinib 0.0509383 0.7838930 0.05094 NA NA
RET sunitinib 0.0511239 0.7838930 0.05112 NA NA
PAX8 lapatinib 0.0512666 0.7838930 0.05127 NA NA
GNB1 pazopanib 0.0512813 0.7838930 0.05128 NA NA
FBXW7 ponatinib 0.0514651 0.7838930 0.05147 NA NA
ATM tretinoin 0.0517302 0.7838930 0.05173 NA NA
U2AF1 palbociclib 0.0518080 0.7838930 0.05181 NA NA
SETBP1 temozolomide 0.0526678 0.7838930 0.05267 NA NA
SF3B1 tretinoin 0.0527261 0.7838930 0.05273 NA NA
BCORL1 ruxolitinib 0.0528280 0.7838930 0.05283 NA NA
CDK6 afatinib 0.0547291 0.7838930 0.05473 NA NA
EZH2 cabozantinib 0.0549646 0.7838930 0.05496 NA NA
NCOA2 ruxolitinib 0.0550670 0.7838930 0.05507 NA NA
FGFR1 midostaurin 0.0551905 0.7838930 0.05519 NA NA
CALR trametinib 0.0553623 0.7838930 0.05536 NA NA
EZH2 lapatinib 0.0555983 0.7838930 0.05560 NA NA
MDM2 docetaxel 0.0557127 0.7838930 0.05571 NA NA
CBLB palbociclib 0.0557547 0.7838930 0.05575 NA NA
JAK1 ruxolitinib 0.0561915 0.7838930 0.05619 NA NA
CTNNB1 dasatinib 0.0566920 0.7838930 0.05669 NA NA
KMT2A sunitinib 0.0567409 0.7838930 0.05674 NA NA
CALR ruxolitinib 0.0572486 0.7838930 0.05725 NA NA
ERBB3 dabrafenib 0.0574180 0.7838930 0.05742 NA NA
TSC1 bosutinib monohydrate 0.0576889 0.7838930 0.05769 NA NA
DNMT3A crizotinib 0.0577322 0.7838930 0.05773 NA NA
TET2 dabrafenib 0.0577458 0.7838930 0.05775 NA NA
U2AF1 ruxolitinib 0.0579826 0.7838930 0.05798 NA NA
JAK3 trametinib 0.0579978 0.7838930 0.05800 NA NA
SETD2 midostaurin 0.0586843 0.7838930 0.05868 NA NA
BCORL1 imatinib 0.0590039 0.7838930 0.05900 NA NA
CDKN2A ruxolitinib 0.0596793 0.7838930 0.05968 NA NA
TP53 trametinib 0.0601194 0.7838930 0.06012 NA NA
PML crizotinib 0.0605225 0.7838930 0.06052 NA NA
RET alectinib 0.0609957 0.7838930 0.06100 NA NA
STAG2 sunitinib 0.0614276 0.7838930 0.06143 NA NA
TP53 rucaparib 0.0614824 0.7838930 0.06148 NA NA
ABL1 ponatinib 0.0614896 0.7838930 0.06149 NA NA
NCOA2 lapatinib 0.0614925 0.7838930 0.06149 NA NA
PTEN cabozantinib 0.0616827 0.7838930 0.06168 NA NA
GNAQ rucaparib 0.0616841 0.7838930 0.06168 NA NA
BCOR imatinib 0.0617869 0.7838930 0.06179 NA NA
ETV6 trametinib 0.0619050 0.7838930 0.06190 NA NA
WT1 erlotinib 0.0619633 0.7838930 0.06196 NA NA
SETBP1 belinostat 0.0619635 0.7838930 0.06196 NA NA
STAT3 tretinoin 0.0621330 0.7838930 0.06213 NA NA
PIGA ponatinib 0.0621845 0.7838930 0.06218 NA NA
EZH2 vismodegib 0.0623528 0.7838930 0.06235 NA NA
GNB1 rucaparib 0.0624029 0.7838930 0.06240 NA NA
PDCD1 trametinib 0.0627906 0.7838930 0.06279 NA NA
JAK3 imatinib 0.0632514 0.7838930 0.06325 NA NA
WHSC1 cabozantinib 0.0636458 0.7838930 0.06365 NA NA
PDGFRA alectinib 0.0638924 0.7838930 0.06389 NA NA
CREBBP ponatinib 0.0643029 0.7838930 0.06430 NA NA
NCOA2 pazopanib 0.0647555 0.7838930 0.06476 NA NA
PTCH1 cabozantinib 0.0650780 0.7838930 0.06508 NA NA
PDGFB ruxolitinib 0.0653257 0.7838930 0.06533 NA NA
TPMT belinostat 0.0656977 0.7838930 0.06570 NA NA
GNAQ docetaxel 0.0658365 0.7838930 0.06584 NA NA
JAK1 palbociclib 0.0659376 0.7838930 0.06594 NA NA
NRAS cabozantinib 0.0660514 0.7838930 0.06605 NA NA
ABL1 ruxolitinib 0.0661262 0.7838930 0.06613 NA NA
EML4 cabozantinib 0.0665447 0.7838930 0.06654 NA NA
PDGFRB belinostat 0.0666829 0.7838930 0.06668 NA NA
SETBP1 alectinib 0.0668146 0.7838930 0.06681 NA NA
VHL bosutinib monohydrate 0.0669017 0.7838930 0.06690 NA NA
CDK4 erlotinib 0.0672825 0.7838930 0.06728 NA NA
TET2 temozolomide 0.0678581 0.7838930 0.06786 NA NA
ZRSR2 vismodegib 0.0682009 0.7838930 0.06820 NA NA
FGFR3 temozolomide 0.0685390 0.7838930 0.06854 NA NA
CDKN2A bosutinib monohydrate 0.0688711 0.7838930 0.06887 NA NA
STAT3 nilotinib 0.0689287 0.7838930 0.06893 NA NA
CYP19A1 ruxolitinib 0.0692408 0.7838930 0.06924 NA NA
DNMT3A docetaxel 0.0692678 0.7838930 0.06927 NA NA
NOTCH2 pazopanib 0.0696792 0.7838930 0.06968 NA NA
BCORL1 midostaurin 0.0699458 0.7838930 0.06995 NA NA
RAD21 cabozantinib 0.0702610 0.7838930 0.07026 NA NA
STAG2 temozolomide 0.0703654 0.7838930 0.07037 NA NA
CDK4 vismodegib 0.0707615 0.7838930 0.07076 NA NA
PTPN11 alectinib 0.0715010 0.7838930 0.07150 NA NA
BRCA2 lapatinib 0.0716745 0.7838930 0.07167 NA NA
FGFR2 imatinib 0.0731536 0.7838930 0.07315 NA NA
KIT trametinib 0.0733706 0.7838930 0.07337 NA NA
CTCF gefitinib 0.0736147 0.7838930 0.07361 NA NA
TPMT dabrafenib 0.0737570 0.7838930 0.07376 NA NA
PIK3CA cabozantinib 0.0738778 0.7838930 0.07388 NA NA
EZH2 crizotinib 0.0741267 0.7838930 0.07413 NA NA
BRAF belinostat 0.0744959 0.7838930 0.07450 NA NA
SRSF2 ponatinib 0.0749201 0.7838930 0.07492 NA NA
IDH1 dabrafenib 0.0752645 0.7838930 0.07526 NA NA
ZRSR2 gefitinib 0.0752776 0.7838930 0.07528 NA NA
CDC73 trametinib 0.0754663 0.7838930 0.07547 NA NA
CSF3R ponatinib 0.0758595 0.7838930 0.07586 NA NA
PDGFRB dasatinib 0.0763115 0.7838930 0.07631 NA NA
IL7R tretinoin 0.0766084 0.7838930 0.07661 NA NA
DPYD crizotinib 0.0771266 0.7838930 0.07713 NA NA
SMO temozolomide 0.0771994 0.7838930 0.07720 NA NA
RAD21 dabrafenib 0.0773282 0.7838930 0.07733 NA NA
GNAS erlotinib 0.0775246 0.7838930 0.07752 NA NA
TSC1 nilotinib 0.0779898 0.7838930 0.07799 NA NA
PRPF8 midostaurin 0.0781692 0.7838930 0.07817 NA NA
ERBB2 crizotinib 0.0782120 0.7838930 0.07821 NA NA
ALK gefitinib 0.0794375 0.7838930 0.07944 NA NA
SMC3 cabozantinib 0.0794697 0.7838930 0.07947 NA NA
CALR dasatinib 0.0794829 0.7838930 0.07948 NA NA
SRSF2 palbociclib 0.0800824 0.7838930 0.08008 NA NA
SF3B1 nilotinib 0.0801719 0.7838930 0.08017 NA NA
ASXL1 ponatinib 0.0806503 0.7838930 0.08065 NA NA
DNAJB1 belinostat 0.0814309 0.7838930 0.08143 NA NA
FGFR2 ponatinib 0.0814419 0.7838930 0.08144 NA NA
DNAJB1 imatinib 0.0817584 0.7838930 0.08176 NA NA
EGF palbociclib 0.0817756 0.7838930 0.08178 NA NA
CSF3R tretinoin 0.0822956 0.7838930 0.08230 NA NA
BTK palbociclib 0.0828013 0.7838930 0.08280 NA NA
BCOR belinostat 0.0836126 0.7838930 0.08361 NA NA
CD274 temozolomide 0.0837166 0.7838930 0.08372 NA NA
PIK3CA midostaurin 0.0837587 0.7838930 0.08376 NA NA
CTNNB1 midostaurin 0.0843253 0.7838930 0.08433 NA NA
STAT3 erlotinib 0.0845539 0.7838930 0.08455 NA NA
FLT3 erlotinib 0.0848216 0.7838930 0.08482 NA NA
SMO tretinoin 0.0848756 0.7838930 0.08488 NA NA
RPL10 cabozantinib 0.0850440 0.7838930 0.08504 NA NA
NT5C2 alectinib 0.0850860 0.7838930 0.08509 NA NA
STAG2 belinostat 0.0851654 0.7838930 0.08517 NA NA
CTLA4 ponatinib 0.0856420 0.7838930 0.08564 NA NA
AKT1 nilotinib 0.0856959 0.7838930 0.08570 NA NA
FBXW7 erlotinib 0.0858748 0.7838930 0.08587 NA NA
GNAS dasatinib 0.0858809 0.7838930 0.08588 NA NA
RPL10 ponatinib 0.0860587 0.7838930 0.08606 NA NA
SSX1 rucaparib 0.0860961 0.7838930 0.08610 NA NA
RPL10 tretinoin 0.0862479 0.7838930 0.08625 NA NA
CDC73 docetaxel 0.0864333 0.7838930 0.08643 NA NA
EZH2 alectinib 0.0868365 0.7838930 0.08684 NA NA
RPL10 alectinib 0.0868754 0.7838930 0.08688 NA NA
RPL10 midostaurin 0.0870012 0.7838930 0.08700 NA NA
DDIT3 nilotinib 0.0871195 0.7838930 0.08712 NA NA
RPL10 afatinib 0.0872294 0.7838930 0.08723 NA NA
MDM2 imatinib 0.0872503 0.7838930 0.08725 NA NA
RPL10 palbociclib 0.0873407 0.7838930 0.08734 NA NA
RPL10 nilotinib 0.0874302 0.7838930 0.08743 NA NA
RUNX1 vismodegib 0.0874842 0.7838930 0.08748 NA NA
FLCN ruxolitinib 0.0877965 0.7838930 0.08780 NA NA
RPL10 crizotinib 0.0879509 0.7838930 0.08795 NA NA
RPL10 sunitinib 0.0880602 0.7838930 0.08806 NA NA
RPL10 dasatinib 0.0880978 0.7838930 0.08810 NA NA
PTPN11 rucaparib 0.0881492 0.7838930 0.08815 NA NA
VHL imatinib 0.0884277 0.7838930 0.08843 NA NA
CD79B temozolomide 0.0884961 0.7838930 0.08850 NA NA
RPL10 ruxolitinib 0.0887038 0.7838930 0.08870 NA NA
PDGFRB midostaurin 0.0887296 0.7838930 0.08873 NA NA
VHL rucaparib 0.0888741 0.7838930 0.08887 NA NA
RPL10 vismodegib 0.0892587 0.7838930 0.08926 NA NA
NCOA2 vismodegib 0.0893861 0.7838930 0.08939 NA NA
JAK2 trametinib 0.0900127 0.7838930 0.09001 NA NA
WT1 sunitinib 0.0903271 0.7838930 0.09033 NA NA
PTEN docetaxel 0.0903770 0.7838930 0.09038 NA NA
WHSC1 docetaxel 0.0905119 0.7838930 0.09051 NA NA
FGFR2 erlotinib 0.0905151 0.7838930 0.09052 NA NA
SRSF2 midostaurin 0.0908838 0.7838930 0.09088 NA NA
UGT1A1 tretinoin 0.0911112 0.7838930 0.09111 NA NA
RPL10 erlotinib 0.0912646 0.7838930 0.09126 NA NA
FBXW7 cabozantinib 0.0914621 0.7838930 0.09146 NA NA
BRCA2 tretinoin 0.0916313 0.7838930 0.09163 NA NA
ABL1 docetaxel 0.0918631 0.7838930 0.09186 NA NA
CBLB docetaxel 0.0924219 0.7838930 0.09242 NA NA
FLCN crizotinib 0.0928500 0.7838930 0.09285 NA NA
CALR ponatinib 0.0929099 0.7838930 0.09291 NA NA
AR dasatinib 0.0930278 0.7838930 0.09303 NA NA
BRCA2 dasatinib 0.0931223 0.7838930 0.09312 NA NA
CD274 belinostat 0.0932739 0.7838930 0.09327 NA NA
CTLA4 cabozantinib 0.0933469 0.7838930 0.09335 NA NA
IDH2 cabozantinib 0.0934140 0.7838930 0.09341 NA NA
SH2B3 vismodegib 0.0934678 0.7838930 0.09347 NA NA
TPMT alectinib 0.0935866 0.7838930 0.09359 NA NA
PTEN rucaparib 0.0938970 0.7838930 0.09390 NA NA
ROS1 erlotinib 0.0943399 0.7838930 0.09434 NA NA
CD274 alectinib 0.0945006 0.7838930 0.09450 NA NA
EML4 imatinib 0.0947179 0.7838930 0.09472 NA NA
GNB1 crizotinib 0.0953243 0.7838930 0.09532 NA NA
RPL10 imatinib 0.0953332 0.7838930 0.09533 NA NA
MYD88 ruxolitinib 0.0954788 0.7838930 0.09548 NA NA
NPM1 dasatinib 0.0957018 0.7838930 0.09570 NA NA
TPMT tretinoin 0.0957413 0.7838930 0.09574 NA NA
RPL10 lapatinib 0.0958239 0.7838930 0.09582 NA NA
CALR pazopanib 0.0961360 0.7838930 0.09614 NA NA
SETBP1 trametinib 0.0962877 0.7838930 0.09629 NA NA
WT1 midostaurin 0.0964995 0.7838930 0.09650 NA NA
PRPF40B temozolomide 0.0965946 0.7838930 0.09659 NA NA
CBL afatinib 0.0971709 0.7838930 0.09717 NA NA
IL7R ponatinib 0.0972285 0.7838930 0.09723 NA NA
MET lapatinib 0.0972319 0.7838930 0.09723 NA NA
DNMT3A rucaparib 0.0975186 0.7838930 0.09752 NA NA
NOTCH1 temozolomide 0.0980228 0.7838930 0.09802 NA NA
TET2 vismodegib 0.0981762 0.7838930 0.09818 NA NA
RET palbociclib 0.0983382 0.7838930 0.09834 NA NA
SMC3 temozolomide 0.0984456 0.7838930 0.09845 NA NA
FGFR2 trametinib 0.0984897 0.7838930 0.09849 NA NA
FLCN lapatinib 0.0985096 0.7838930 0.09851 NA NA
AKT3 alectinib 0.0987542 0.7838930 0.09875 NA NA
MAP2K1 temozolomide 0.0987836 0.7838930 0.09878 NA NA
ERBB2 gefitinib 0.0989296 0.7838930 0.09893 NA NA
FLT3 imatinib 0.0990080 0.7838930 0.09901 NA NA
CTLA4 tretinoin 0.0990569 0.7838930 0.09906 NA NA
JAK1 cabozantinib 0.0992758 0.7838930 0.09928 NA NA
CTLA4 bosutinib monohydrate 0.0999893 0.7838930 0.09999 NA NA
PRPF8 pazopanib 0.1000832 0.7838930 0.10008 NA NA
BTK bosutinib monohydrate 0.1001931 0.7838930 0.10019 NA NA
WT1 trametinib 0.1003839 0.7838930 0.10038 NA NA
JAK2 cabozantinib 0.1004191 0.7838930 0.10042 NA NA
NT5C2 dabrafenib 0.1005154 0.7838930 0.10052 NA NA
FLCN imatinib 0.1005378 0.7838930 0.10054 NA NA
RUNX1 lapatinib 0.1014759 0.7838930 0.10148 NA NA
XPO1 trametinib 0.1015015 0.7838930 0.10150 NA NA
MYCN tretinoin 0.1019536 0.7838930 0.10195 NA NA
GNB1 dasatinib 0.1021196 0.7838930 0.10212 NA NA
ETV6 tretinoin 0.1021380 0.7838930 0.10214 NA NA
SH2B3 ponatinib 0.1023151 0.7838930 0.10232 NA NA
BRCA2 palbociclib 0.1027690 0.7838930 0.10277 NA NA
GNA11 pazopanib 0.1031129 0.7838930 0.10311 NA NA
RPL10 gefitinib 0.1035789 0.7838930 0.10358 NA NA
PTEN tretinoin 0.1038671 0.7838930 0.10387 NA NA
ZRSR2 palbociclib 0.1039936 0.7838930 0.10399 NA NA
SETBP1 crizotinib 0.1040172 0.7838930 0.10402 NA NA
MYD88 trametinib 0.1042757 0.7838930 0.10428 NA NA
BCOR midostaurin 0.1045093 0.7838930 0.10451 NA NA
MAP2K2 bosutinib monohydrate 0.1046536 0.7838930 0.10465 NA NA
PML midostaurin 0.1046555 0.7838930 0.10466 NA NA
SMC3 dasatinib 0.1047138 0.7838930 0.10471 NA NA
PAX8 docetaxel 0.1054555 0.7838930 0.10546 NA NA
DNAJB1 nilotinib 0.1060679 0.7838930 0.10607 NA NA
TSC2 tretinoin 0.1061419 0.7838930 0.10614 NA NA
CXCR4 gefitinib 0.1064188 0.7838930 0.10642 NA NA
AKT3 dasatinib 0.1068213 0.7838930 0.10682 NA NA
CTLA4 vismodegib 0.1069540 0.7838930 0.10695 NA NA
EED pazopanib 0.1069880 0.7838930 0.10699 NA NA
ABL1 trametinib 0.1069974 0.7838930 0.10700 NA NA
TET2 nilotinib 0.1073900 0.7838930 0.10739 NA NA
PDGFRA gefitinib 0.1077698 0.7838930 0.10777 NA NA
XPO1 nilotinib 0.1080468 0.7838930 0.10805 NA NA
CYP19A1 imatinib 0.1086620 0.7838930 0.10866 NA NA
PHF6 dabrafenib 0.1087549 0.7838930 0.10875 NA NA
U2AF1 docetaxel 0.1088557 0.7838930 0.10886 NA NA
CRLF2 erlotinib 0.1091200 0.7838930 0.10912 NA NA
BCORL1 belinostat 0.1094027 0.7838930 0.10940 NA NA
CBL lapatinib 0.1099732 0.7838930 0.10997 NA NA
CD274 cabozantinib 0.1100504 0.7838930 0.11005 NA NA
ERBB3 midostaurin 0.1104412 0.7838930 0.11044 NA NA
MDM2 rucaparib 0.1105299 0.7838930 0.11053 NA NA
CXCR4 ponatinib 0.1109241 0.7838930 0.11092 NA NA
SMC3 alectinib 0.1109591 0.7838930 0.11096 NA NA
FLCN alectinib 0.1110717 0.7838930 0.11107 NA NA
TP53 afatinib 0.1112751 0.7838930 0.11128 NA NA
TSC2 dabrafenib 0.1118016 0.7838930 0.11180 NA NA
PAX5 sunitinib 0.1124728 0.7838930 0.11247 NA NA
RUNX1 tretinoin 0.1125899 0.7838930 0.11259 NA NA
AKT3 pazopanib 0.1128443 0.7838930 0.11284 NA NA
CBL dabrafenib 0.1130546 0.7838930 0.11305 NA NA
BRAF palbociclib 0.1131136 0.7838930 0.11311 NA NA
FGFR2 cabozantinib 0.1132666 0.7838930 0.11327 NA NA
ROS1 tretinoin 0.1136424 0.7838930 0.11364 NA NA
CRLF2 lapatinib 0.1138543 0.7838930 0.11385 NA NA
SETD2 dabrafenib 0.1138566 0.7838930 0.11386 NA NA
PRPF40B erlotinib 0.1140652 0.7838930 0.11407 NA NA
MDM2 cabozantinib 0.1141686 0.7838930 0.11417 NA NA
STAT3 ponatinib 0.1142358 0.7838930 0.11424 NA NA
SRSF2 gefitinib 0.1142775 0.7838930 0.11428 NA NA
ROS1 ponatinib 0.1143242 0.7838930 0.11432 NA NA
FANCL vismodegib 0.1143467 0.7838930 0.11435 NA NA
CREBBP dasatinib 0.1144672 0.7838930 0.11447 NA NA
AKT2 temozolomide 0.1148997 0.7838930 0.11490 NA NA
ESR1 temozolomide 0.1154649 0.7838930 0.11546 NA NA
ATM dabrafenib 0.1159223 0.7838930 0.11592 NA NA
G6PD bosutinib monohydrate 0.1162560 0.7838930 0.11626 NA NA
FGFR1 palbociclib 0.1164096 0.7838930 0.11641 NA NA
NRAS lapatinib 0.1166057 0.7838930 0.11661 NA NA
STAT3 vismodegib 0.1166536 0.7838930 0.11665 NA NA
GATA1 gefitinib 0.1169619 0.7838930 0.11696 NA NA
FANCL ponatinib 0.1174239 0.7838930 0.11742 NA NA
BRCA2 imatinib 0.1174800 0.7838930 0.11748 NA NA
XPO1 crizotinib 0.1179406 0.7838930 0.11794 NA NA
ETV6 pazopanib 0.1180629 0.7838930 0.11806 NA NA
GATA3 crizotinib 0.1184833 0.7838930 0.11848 NA NA
CBL erlotinib 0.1192013 0.7838930 0.11920 NA NA
EZH2 ponatinib 0.1193818 0.7838930 0.11938 NA NA
VHL palbociclib 0.1197067 0.7838930 0.11971 NA NA
CTLA4 nilotinib 0.1201225 0.7838930 0.12012 NA NA
PAX5 ruxolitinib 0.1202681 0.7838930 0.12027 NA NA
RPL10 docetaxel 0.1206554 0.7838930 0.12066 NA NA
SMO docetaxel 0.1208460 0.7838930 0.12085 NA NA
MDM2 crizotinib 0.1214898 0.7838930 0.12149 NA NA
BTK pazopanib 0.1215251 0.7838930 0.12153 NA NA
PDGFRA tretinoin 0.1216752 0.7838930 0.12168 NA NA
CDK6 ponatinib 0.1216781 0.7838930 0.12168 NA NA
RPL10 bosutinib monohydrate 0.1218958 0.7838930 0.12190 NA NA
PIK3CA rucaparib 0.1220643 0.7838930 0.12206 NA NA
KMT2A palbociclib 0.1221128 0.7838930 0.12211 NA NA
NCOA2 belinostat 0.1222655 0.7838930 0.12227 NA NA
XPO1 afatinib 0.1226343 0.7838930 0.12263 NA NA
MGMT afatinib 0.1228036 0.7838930 0.12280 NA NA
ERBB2 lapatinib 0.1230985 0.7838930 0.12310 NA NA
EED rucaparib 0.1231156 0.7838930 0.12312 NA NA
TPMT ruxolitinib 0.1231531 0.7838930 0.12315 NA NA
ERBB2 midostaurin 0.1231748 0.7838930 0.12317 NA NA
IDH2 belinostat 0.1232427 0.7838930 0.12324 NA NA
PIGA imatinib 0.1236551 0.7838930 0.12366 NA NA
RIT1 imatinib 0.1236551 0.7838930 0.12366 NA NA
SMC1A imatinib 0.1238297 0.7838930 0.12383 NA NA
PAX5 cabozantinib 0.1242237 0.7838930 0.12422 NA NA
CDK6 crizotinib 0.1242377 0.7838930 0.12424 NA NA
GATA3 lapatinib 0.1247292 0.7838930 0.12473 NA NA
FANCL alectinib 0.1248849 0.7838930 0.12488 NA NA
KIT tretinoin 0.1249785 0.7838930 0.12498 NA NA
GNB1 trametinib 0.1250888 0.7838930 0.12509 NA NA
UGT1A1 bosutinib monohydrate 0.1252560 0.7838930 0.12526 NA NA
MAP2K2 belinostat 0.1254344 0.7838930 0.12543 NA NA
ALK dabrafenib 0.1254923 0.7838930 0.12549 NA NA
VHL belinostat 0.1257218 0.7838930 0.12572 NA NA
MYD88 docetaxel 0.1258052 0.7838930 0.12581 NA NA
CDKN2A ponatinib 0.1262284 0.7838930 0.12623 NA NA
NRAS gefitinib 0.1262378 0.7838930 0.12624 NA NA
MGMT gefitinib 0.1263998 0.7838930 0.12640 NA NA
PTCH1 midostaurin 0.1266216 0.7838930 0.12662 NA NA
NCOA2 tretinoin 0.1266814 0.7838930 0.12668 NA NA
RUNX1 ruxolitinib 0.1276182 0.7838930 0.12762 NA NA
CBLB dasatinib 0.1279141 0.7838930 0.12791 NA NA
MET erlotinib 0.1281272 0.7838930 0.12813 NA NA
FLCN sunitinib 0.1281801 0.7838930 0.12818 NA NA
SETD2 alectinib 0.1283291 0.7838930 0.12833 NA NA
CBL sunitinib 0.1283819 0.7838930 0.12838 NA NA
MGMT erlotinib 0.1288089 0.7838930 0.12881 NA NA
FGFR1 trametinib 0.1292149 0.7838930 0.12921 NA NA
KMT2A belinostat 0.1296916 0.7838930 0.12969 NA NA
GNA11 ponatinib 0.1297896 0.7838930 0.12979 NA NA
MET crizotinib 0.1305419 0.7838930 0.13054 NA NA
NOTCH1 rucaparib 0.1306394 0.7838930 0.13064 NA NA
MAP2K1 alectinib 0.1306584 0.7838930 0.13066 NA NA
ERBB2 temozolomide 0.1311049 0.7838930 0.13110 NA NA
IDH2 temozolomide 0.1311580 0.7838930 0.13116 NA NA
NOTCH2 afatinib 0.1313985 0.7838930 0.13140 NA NA
ATM crizotinib 0.1315741 0.7838930 0.13157 NA NA
FLCN pazopanib 0.1317962 0.7838930 0.13180 NA NA
GATA1 afatinib 0.1322836 0.7838930 0.13228 NA NA
TSC2 nilotinib 0.1328358 0.7838930 0.13284 NA NA
ETV6 imatinib 0.1331229 0.7838930 0.13312 NA NA
PDGFRA afatinib 0.1332170 0.7838930 0.13322 NA NA
NT5C2 palbociclib 0.1332752 0.7838930 0.13328 NA NA
FLCN erlotinib 0.1333236 0.7838930 0.13332 NA NA
TP53 cabozantinib 0.1336110 0.7838930 0.13361 NA NA
JAK3 nilotinib 0.1339154 0.7838930 0.13392 NA NA
CALR erlotinib 0.1340397 0.7838930 0.13404 NA NA
JAK3 rucaparib 0.1342473 0.7838930 0.13425 NA NA
PTCH1 gefitinib 0.1346354 0.7838930 0.13464 NA NA
PDGFRA nilotinib 0.1346957 0.7838930 0.13470 NA NA
MET belinostat 0.1348014 0.7838930 0.13480 NA NA
EGFR dabrafenib 0.1350723 0.7838930 0.13507 NA NA
PDGFRA trametinib 0.1350935 0.7838930 0.13509 NA NA
JAK3 ruxolitinib 0.1351891 0.7838930 0.13519 NA NA
EED temozolomide 0.1353524 0.7838930 0.13535 NA NA
RIT1 dasatinib 0.1353958 0.7838930 0.13540 NA NA
PTPN11 cabozantinib 0.1354785 0.7838930 0.13548 NA NA
SMC1A dasatinib 0.1356364 0.7838930 0.13564 NA NA
MET dabrafenib 0.1361932 0.7838930 0.13619 NA NA
CREBBP gefitinib 0.1371167 0.7838930 0.13712 NA NA
TP53 dabrafenib 0.1373973 0.7838930 0.13740 NA NA
GNAS ponatinib 0.1378710 0.7838930 0.13787 NA NA
CDKN2A rucaparib 0.1382694 0.7838930 0.13827 NA NA
ASXL1 alectinib 0.1383344 0.7838930 0.13833 NA NA
JAK2 vismodegib 0.1385135 0.7838930 0.13851 NA NA
ALK trametinib 0.1385711 0.7838930 0.13857 NA NA
GNB1 temozolomide 0.1386197 0.7838930 0.13862 NA NA
RAD21 vismodegib 0.1386885 0.7838930 0.13869 NA NA
TSC2 trametinib 0.1392327 0.7838930 0.13923 NA NA
CDK4 sunitinib 0.1393853 0.7838930 0.13939 NA NA
PAX8 erlotinib 0.1394332 0.7838930 0.13943 NA NA
MPL nilotinib 0.1396520 0.7838930 0.13965 NA NA
CBL crizotinib 0.1406039 0.7838930 0.14060 NA NA
PDGFRA cabozantinib 0.1407290 0.7838930 0.14073 NA NA
EED alectinib 0.1407867 0.7838930 0.14079 NA NA
ATM midostaurin 0.1408355 0.7838930 0.14084 NA NA
UGT1A1 lapatinib 0.1409522 0.7838930 0.14095 NA NA
BRAF rucaparib 0.1413053 0.7838930 0.14131 NA NA
GNAQ alectinib 0.1418350 0.7838930 0.14183 NA NA
CDC73 temozolomide 0.1419861 0.7838930 0.14199 NA NA
AKT1 midostaurin 0.1419954 0.7838930 0.14200 NA NA
FGFR1 erlotinib 0.1424666 0.7838930 0.14247 NA NA
RIT1 rucaparib 0.1426020 0.7838930 0.14260 NA NA
STAT3 ruxolitinib 0.1427439 0.7838930 0.14274 NA NA
WHSC1 dasatinib 0.1428838 0.7838930 0.14288 NA NA
ALK lapatinib 0.1428928 0.7838930 0.14289 NA NA
MAP2K1 imatinib 0.1429961 0.7838930 0.14300 NA NA
KIT cabozantinib 0.1434514 0.7838930 0.14345 NA NA
KRAS cabozantinib 0.1437272 0.7838930 0.14373 NA NA
FGFR3 afatinib 0.1440811 0.7838930 0.14408 NA NA
DNAJB1 sunitinib 0.1441839 0.7838930 0.14418 NA NA
GATA2 bosutinib monohydrate 0.1441992 0.7838930 0.14420 NA NA
MAP2K1 afatinib 0.1443384 0.7838930 0.14434 NA NA
GATA3 trametinib 0.1446868 0.7838930 0.14469 NA NA
PDGFB erlotinib 0.1449924 0.7838930 0.14499 NA NA
CBL belinostat 0.1450619 0.7838930 0.14506 NA NA
MAP2K2 palbociclib 0.1451389 0.7838930 0.14514 NA NA
ERBB3 imatinib 0.1453832 0.7838930 0.14538 NA NA
CTNNB1 nilotinib 0.1455938 0.7838930 0.14559 NA NA
NOTCH1 lapatinib 0.1462669 0.7838930 0.14627 NA NA
CBL dasatinib 0.1464269 0.7838930 0.14643 NA NA
PRPF8 rucaparib 0.1466626 0.7838930 0.14666 NA NA
CTLA4 alectinib 0.1466805 0.7838930 0.14668 NA NA
RUNX1 sunitinib 0.1467646 0.7838930 0.14676 NA NA
UGT1A1 erlotinib 0.1468898 0.7838930 0.14689 NA NA
EGF imatinib 0.1470992 0.7838930 0.14710 NA NA
FANCL imatinib 0.1471141 0.7838930 0.14711 NA NA
RET docetaxel 0.1477981 0.7838930 0.14780 NA NA
IL7R rucaparib 0.1489089 0.7838930 0.14891 NA NA
BCOR cabozantinib 0.1489401 0.7838930 0.14894 NA NA
CRLF2 cabozantinib 0.1490076 0.7838930 0.14901 NA NA
G6PD alectinib 0.1491983 0.7838930 0.14920 NA NA
EZH2 afatinib 0.1496126 0.7838930 0.14961 NA NA
NPM1 belinostat 0.1498150 0.7838930 0.14982 NA NA
IL7R trametinib 0.1502552 0.7838930 0.15026 NA NA
IDH2 rucaparib 0.1502920 0.7838930 0.15029 NA NA
SF1 belinostat 0.1506532 0.7838930 0.15065 NA NA
ERBB4 cabozantinib 0.1509455 0.7838930 0.15095 NA NA
MET imatinib 0.1511805 0.7838930 0.15118 NA NA
RPL10 pazopanib 0.1515056 0.7838930 0.15151 NA NA
CDC73 dabrafenib 0.1516303 0.7838930 0.15163 NA NA
AKT1 bosutinib monohydrate 0.1516806 0.7838930 0.15168 NA NA
FGFR1 ruxolitinib 0.1519639 0.7838930 0.15196 NA NA
CRLF2 dabrafenib 0.1520171 0.7838930 0.15202 NA NA
ZRSR2 ruxolitinib 0.1522656 0.7838930 0.15227 NA NA
BRAF alectinib 0.1526449 0.7838930 0.15264 NA NA
CALR nilotinib 0.1528002 0.7838930 0.15280 NA NA
PRPF40B ruxolitinib 0.1533423 0.7838930 0.15334 NA NA
CTCF docetaxel 0.1533534 0.7838930 0.15335 NA NA
XPO1 dasatinib 0.1535899 0.7838930 0.15359 NA NA
FLT3 nilotinib 0.1535908 0.7838930 0.15359 NA NA
IKZF1 ruxolitinib 0.1536440 0.7838930 0.15364 NA NA
PTPN11 ponatinib 0.1536929 0.7838930 0.15369 NA NA
EZH2 nilotinib 0.1537478 0.7838930 0.15375 NA NA
PRPF8 temozolomide 0.1540934 0.7838930 0.15409 NA NA
IL7R ruxolitinib 0.1543734 0.7838930 0.15437 NA NA
WHSC1 vismodegib 0.1543822 0.7838930 0.15438 NA NA
PDCD1 dabrafenib 0.1546264 0.7838930 0.15463 NA NA
ATM erlotinib 0.1547223 0.7838930 0.15472 NA NA
GNAQ trametinib 0.1547547 0.7838930 0.15475 NA NA
FGFR3 erlotinib 0.1556510 0.7867938 0.15565 NA NA
IL7R alectinib 0.1558610 0.7867938 0.15586 NA NA
IKZF1 dasatinib 0.1560706 0.7867938 0.15607 NA NA
PTEN ruxolitinib 0.1566767 0.7885977 0.15668 NA NA
WHSC1 trametinib 0.1570917 0.7894353 0.15709 NA NA
NRAS pazopanib 0.1573839 0.7896543 0.15738 NA NA
AKT3 midostaurin 0.1590833 0.7957730 0.15908 NA NA
ZRSR2 dabrafenib 0.1591476 0.7957730 0.15915 NA NA
TSC2 afatinib 0.1594651 0.7957730 0.15947 NA NA
CD79B dabrafenib 0.1596056 0.7957730 0.15961 NA NA
ERBB4 gefitinib 0.1599159 0.7960703 0.15992 NA NA
RIT1 sunitinib 0.1606843 0.7970975 0.16068 NA NA
CREBBP pazopanib 0.1610486 0.7970975 0.16105 NA NA
SMC1A sunitinib 0.1610595 0.7970975 0.16106 NA NA
CALR midostaurin 0.1612397 0.7970975 0.16124 NA NA
HRAS palbociclib 0.1615122 0.7970975 0.16151 NA NA
MAP2K1 vismodegib 0.1617145 0.7970975 0.16171 NA NA
HRAS alectinib 0.1622969 0.7970975 0.16230 NA NA
BRAF vismodegib 0.1624273 0.7970975 0.16243 NA NA
IDH2 afatinib 0.1625545 0.7970975 0.16255 NA NA
TSC2 temozolomide 0.1628876 0.7970975 0.16289 NA NA
NT5C2 imatinib 0.1629599 0.7970975 0.16296 NA NA
CDK4 crizotinib 0.1634861 0.7970975 0.16349 NA NA
MYCN pazopanib 0.1635137 0.7970975 0.16351 NA NA
GNAS bosutinib monohydrate 0.1636359 0.7970975 0.16364 NA NA
CD79B tretinoin 0.1643471 0.7993358 0.16435 NA NA
BCOR trametinib 0.1650504 0.7996485 0.16505 NA NA
RUNX1 temozolomide 0.1651179 0.7996485 0.16512 NA NA
EGFR gefitinib 0.1651667 0.7996485 0.16517 NA NA
GNB1 cabozantinib 0.1658940 0.8015333 0.16589 NA NA
NRAS erlotinib 0.1660607 0.8015333 0.16606 NA NA
TET2 ruxolitinib 0.1663985 0.8019448 0.16640 NA NA
FGFR2 pazopanib 0.1667180 0.8022670 0.16672 NA NA
TP53 tretinoin 0.1673997 0.8024203 0.16740 NA NA
GATA1 crizotinib 0.1678222 0.8024203 0.16782 NA NA
KMT2A dabrafenib 0.1680952 0.8024203 0.16810 NA NA
PTPN11 ruxolitinib 0.1682990 0.8024203 0.16830 NA NA
BRCA1 midostaurin 0.1683042 0.8024203 0.16830 NA NA
FBXW7 afatinib 0.1685081 0.8024203 0.16851 NA NA
DDIT3 alectinib 0.1687949 0.8024203 0.16879 NA NA
AKT2 rucaparib 0.1688628 0.8024203 0.16886 NA NA
NOTCH1 docetaxel 0.1690237 0.8024203 0.16902 NA NA
MAP2K1 docetaxel 0.1700087 0.8047151 0.17001 NA NA
ROS1 docetaxel 0.1704250 0.8047151 0.17043 NA NA
PIK3CA dabrafenib 0.1707493 0.8047151 0.17075 NA NA
TSC1 trametinib 0.1714196 0.8047151 0.17142 NA NA
VHL midostaurin 0.1715663 0.8047151 0.17157 NA NA
AKT3 temozolomide 0.1716414 0.8047151 0.17164 NA NA
STAG2 imatinib 0.1717038 0.8047151 0.17170 NA NA
GATA1 bosutinib monohydrate 0.1718658 0.8047151 0.17187 NA NA
PDGFB tretinoin 0.1722109 0.8047151 0.17221 NA NA
CDK4 palbociclib 0.1723047 0.8047151 0.17230 NA NA
EED ruxolitinib 0.1723166 0.8047151 0.17232 NA NA
EED dabrafenib 0.1727152 0.8047151 0.17272 NA NA
GATA2 sunitinib 0.1728009 0.8047151 0.17280 NA NA
AR rucaparib 0.1732681 0.8049487 0.17327 NA NA
PTCH1 tretinoin 0.1733580 0.8049487 0.17336 NA NA
PTEN pazopanib 0.1738665 0.8055178 0.17387 NA NA
VHL ruxolitinib 0.1743680 0.8055178 0.17437 NA NA
RPL10 rucaparib 0.1749059 0.8055178 0.17491 NA NA
CBLB rucaparib 0.1753511 0.8055178 0.17535 NA NA
EML4 tretinoin 0.1756579 0.8055178 0.17566 NA NA
TSC2 crizotinib 0.1757036 0.8055178 0.17570 NA NA
MPL gefitinib 0.1763514 0.8055178 0.17635 NA NA
CD274 rucaparib 0.1767650 0.8055178 0.17677 NA NA
VHL crizotinib 0.1771829 0.8055178 0.17718 NA NA
DNAJB1 dasatinib 0.1772222 0.8055178 0.17722 NA NA
CALR docetaxel 0.1774390 0.8055178 0.17744 NA NA
ESR1 nilotinib 0.1779167 0.8055178 0.17792 NA NA
SF1 imatinib 0.1779288 0.8055178 0.17793 NA NA
NPM1 cabozantinib 0.1781069 0.8055178 0.17811 NA NA
CTCF ruxolitinib 0.1782204 0.8055178 0.17822 NA NA
JAK2 docetaxel 0.1783666 0.8055178 0.17837 NA NA
SMO lapatinib 0.1785842 0.8055178 0.17858 NA NA
GNAS nilotinib 0.1788003 0.8055178 0.17880 NA NA
SF1 cabozantinib 0.1792187 0.8055178 0.17922 NA NA
MDM2 palbociclib 0.1794132 0.8055178 0.17941 NA NA
PAX5 erlotinib 0.1794822 0.8055178 0.17948 NA NA
PIGA erlotinib 0.1794822 0.8055178 0.17948 NA NA
PAX5 afatinib 0.1796773 0.8055178 0.17968 NA NA
ZRSR2 afatinib 0.1797553 0.8055178 0.17976 NA NA
FBXW7 temozolomide 0.1799955 0.8055178 0.18000 NA NA
ERBB2 belinostat 0.1805478 0.8055178 0.18055 NA NA
FGFR1 afatinib 0.1808783 0.8055178 0.18088 NA NA
STAT3 alectinib 0.1812298 0.8055178 0.18123 NA NA
RIT1 belinostat 0.1819372 0.8055178 0.18194 NA NA
G6PD docetaxel 0.1822668 0.8055178 0.18227 NA NA
MYD88 afatinib 0.1823685 0.8055178 0.18237 NA NA
SMC3 rucaparib 0.1824393 0.8055178 0.18244 NA NA
FGFR3 belinostat 0.1830783 0.8055178 0.18308 NA NA
WT1 dasatinib 0.1833368 0.8055178 0.18334 NA NA
SMC1A gefitinib 0.1838148 0.8055178 0.18381 NA NA
KRAS afatinib 0.1838668 0.8055178 0.18387 NA NA
CTLA4 temozolomide 0.1841506 0.8055178 0.18415 NA NA
MET afatinib 0.1841947 0.8055178 0.18419 NA NA
SF3B1 lapatinib 0.1846865 0.8055178 0.18469 NA NA
SETBP1 sunitinib 0.1847349 0.8055178 0.18473 NA NA
ABL1 belinostat 0.1850848 0.8055178 0.18508 NA NA
GATA1 palbociclib 0.1856767 0.8055178 0.18568 NA NA
STAG2 pazopanib 0.1860023 0.8055178 0.18600 NA NA
PAX8 cabozantinib 0.1865583 0.8055178 0.18656 NA NA
GNA11 rucaparib 0.1867700 0.8055178 0.18677 NA NA
DNMT3A nilotinib 0.1870610 0.8055178 0.18706 NA NA
CD274 ruxolitinib 0.1870849 0.8055178 0.18708 NA NA
SMC3 midostaurin 0.1875982 0.8055178 0.18760 NA NA
SSX1 palbociclib 0.1877964 0.8055178 0.18780 NA NA
PTCH1 bosutinib monohydrate 0.1879013 0.8055178 0.18790 NA NA
BRCA2 alectinib 0.1881297 0.8055178 0.18813 NA NA
EGF belinostat 0.1881458 0.8055178 0.18815 NA NA
ALK sunitinib 0.1882759 0.8055178 0.18828 NA NA
ALK afatinib 0.1885392 0.8055178 0.18854 NA NA
TSC2 sunitinib 0.1886391 0.8055178 0.18864 NA NA
PAX5 temozolomide 0.1887930 0.8055178 0.18879 NA NA
RIT1 afatinib 0.1891551 0.8055178 0.18916 NA NA
CTNNB1 alectinib 0.1894137 0.8055178 0.18941 NA NA
TET2 ponatinib 0.1895014 0.8055178 0.18950 NA NA
PDGFRB dabrafenib 0.1895855 0.8055178 0.18959 NA NA
MPL cabozantinib 0.1896077 0.8055178 0.18961 NA NA
RAD21 crizotinib 0.1897781 0.8055178 0.18978 NA NA
DDIT3 docetaxel 0.1899483 0.8055178 0.18995 NA NA
DDIT3 pazopanib 0.1903063 0.8055178 0.19031 NA NA
NCOA2 erlotinib 0.1903671 0.8055178 0.19037 NA NA
RAD21 tretinoin 0.1903979 0.8055178 0.19040 NA NA
CRLF2 palbociclib 0.1904735 0.8055178 0.19047 NA NA
IKZF1 tretinoin 0.1918545 0.8075109 0.19185 NA NA
CRLF2 tretinoin 0.1923461 0.8075109 0.19235 NA NA
GNB1 dabrafenib 0.1924605 0.8075109 0.19246 NA NA
PDCD1 docetaxel 0.1924908 0.8075109 0.19249 NA NA
TSC1 midostaurin 0.1925940 0.8075109 0.19259 NA NA
ATM ponatinib 0.1926153 0.8075109 0.19262 NA NA
NPM1 imatinib 0.1935911 0.8075109 0.19359 NA NA
GNA11 vismodegib 0.1941667 0.8075109 0.19417 NA NA
NPM1 midostaurin 0.1944832 0.8075109 0.19448 NA NA
MGMT cabozantinib 0.1946541 0.8075109 0.19465 NA NA
CDC73 rucaparib 0.1947424 0.8075109 0.19474 NA NA
PML alectinib 0.1950849 0.8075109 0.19508 NA NA
ERBB4 crizotinib 0.1962570 0.8075109 0.19626 NA NA
PHF6 docetaxel 0.1965851 0.8075109 0.19659 NA NA
CALR rucaparib 0.1970713 0.8075109 0.19707 NA NA
FLT3 rucaparib 0.1971116 0.8075109 0.19711 NA NA
CXCR4 lapatinib 0.1971848 0.8075109 0.19718 NA NA
CTCF crizotinib 0.1973464 0.8075109 0.19735 NA NA
EZH2 erlotinib 0.1974234 0.8075109 0.19742 NA NA
BRAF ruxolitinib 0.1976786 0.8075109 0.19768 NA NA
FGFR3 midostaurin 0.1981794 0.8075109 0.19818 NA NA
PDCD1 nilotinib 0.1981914 0.8075109 0.19819 NA NA
VHL vismodegib 0.1982659 0.8075109 0.19827 NA NA
PRPF40B imatinib 0.1984027 0.8075109 0.19840 NA NA
ZRSR2 imatinib 0.1984027 0.8075109 0.19840 NA NA
SETBP1 nilotinib 0.1987831 0.8075109 0.19878 NA NA
TSC2 docetaxel 0.1988212 0.8075109 0.19882 NA NA
SETD2 cabozantinib 0.1995660 0.8075109 0.19957 NA NA
GNAS cabozantinib 0.1996756 0.8075109 0.19968 NA NA
CEBPA midostaurin 0.1997120 0.8075109 0.19971 NA NA
JAK2 gefitinib 0.1997501 0.8075109 0.19975 NA NA
JAK1 alectinib 0.2001873 0.8075109 0.20019 NA NA
ESR1 gefitinib 0.2002313 0.8075109 0.20023 NA NA
GNAQ belinostat 0.2006145 0.8075109 0.20061 NA NA
UGT1A1 palbociclib 0.2007621 0.8075109 0.20076 NA NA
GNB1 nilotinib 0.2017232 0.8075109 0.20172 NA NA
PML palbociclib 0.2018104 0.8075109 0.20181 NA NA
KIT dabrafenib 0.2027554 0.8075109 0.20276 NA NA
PDGFRB erlotinib 0.2028937 0.8075109 0.20289 NA NA
PRPF40B midostaurin 0.2032107 0.8075109 0.20321 NA NA
U2AF1 rucaparib 0.2035438 0.8075109 0.20354 NA NA
CD79B imatinib 0.2040208 0.8075109 0.20402 NA NA
GNAQ imatinib 0.2040208 0.8075109 0.20402 NA NA
IDH2 vismodegib 0.2041835 0.8075109 0.20418 NA NA
BCORL1 dabrafenib 0.2043963 0.8075109 0.20440 NA NA
PHF6 tretinoin 0.2045860 0.8075109 0.20459 NA NA
PAX5 crizotinib 0.2046329 0.8075109 0.20463 NA NA
BCORL1 afatinib 0.2049112 0.8075109 0.20491 NA NA
TSC2 ponatinib 0.2051961 0.8075109 0.20520 NA NA
CDK6 dabrafenib 0.2053813 0.8075109 0.20538 NA NA
FLT3 dasatinib 0.2059686 0.8075109 0.20597 NA NA
MDM2 tretinoin 0.2059902 0.8075109 0.20599 NA NA
STAG2 ruxolitinib 0.2060015 0.8075109 0.20600 NA NA
NT5C2 sunitinib 0.2060779 0.8075109 0.20608 NA NA
CREBBP temozolomide 0.2063925 0.8075109 0.20639 NA NA
BCORL1 alectinib 0.2070853 0.8075109 0.20709 NA NA
ERBB4 palbociclib 0.2071288 0.8075109 0.20713 NA NA
CTNNB1 imatinib 0.2072389 0.8075109 0.20724 NA NA
EML4 vismodegib 0.2074836 0.8075109 0.20748 NA NA
GATA3 temozolomide 0.2077388 0.8075109 0.20774 NA NA
JAK1 ponatinib 0.2077854 0.8075109 0.20779 NA NA
GATA3 alectinib 0.2079277 0.8075109 0.20793 NA NA
CDK6 gefitinib 0.2081255 0.8075109 0.20813 NA NA
CEBPA tretinoin 0.2087521 0.8075109 0.20875 NA NA
RAD21 afatinib 0.2088507 0.8075109 0.20885 NA NA
PTEN alectinib 0.2092253 0.8075109 0.20923 NA NA
PDCD1 crizotinib 0.2092666 0.8075109 0.20927 NA NA
CALR cabozantinib 0.2096259 0.8075109 0.20963 NA NA
JAK1 erlotinib 0.2097544 0.8075109 0.20975 NA NA
MAP2K1 bosutinib monohydrate 0.2099067 0.8075109 0.20991 NA NA
SRSF2 vismodegib 0.2103014 0.8075109 0.21030 NA NA
CTNNB1 afatinib 0.2104143 0.8075109 0.21041 NA NA
JAK2 temozolomide 0.2108300 0.8075109 0.21083 NA NA
MAP2K2 midostaurin 0.2109847 0.8075109 0.21098 NA NA
G6PD afatinib 0.2109900 0.8075109 0.21099 NA NA
EGFR crizotinib 0.2113667 0.8075109 0.21137 NA NA
GATA1 dabrafenib 0.2115052 0.8075109 0.21151 NA NA
ABL1 palbociclib 0.2122468 0.8075109 0.21225 NA NA
PTPN11 bosutinib monohydrate 0.2124694 0.8075109 0.21247 NA NA
STAG2 nilotinib 0.2125771 0.8075109 0.21258 NA NA
SF1 bosutinib monohydrate 0.2126871 0.8075109 0.21269 NA NA
IKZF1 nilotinib 0.2133452 0.8075109 0.21335 NA NA
U2AF1 cabozantinib 0.2134027 0.8075109 0.21340 NA NA
AR lapatinib 0.2135960 0.8075109 0.21360 NA NA
PDCD1 palbociclib 0.2138133 0.8075109 0.21381 NA NA
FGFR1 docetaxel 0.2138153 0.8075109 0.21382 NA NA
CDKN2A pazopanib 0.2139961 0.8075109 0.21400 NA NA
SF3B1 docetaxel 0.2143435 0.8075109 0.21434 NA NA
STAG2 alectinib 0.2144126 0.8075109 0.21441 NA NA
SMO dasatinib 0.2145199 0.8075109 0.21452 NA NA
EGF dabrafenib 0.2146958 0.8075109 0.21470 NA NA
ESR1 palbociclib 0.2146985 0.8075109 0.21470 NA NA
MAP2K1 trametinib 0.2151783 0.8075109 0.21518 NA NA
JAK3 dasatinib 0.2151836 0.8075109 0.21518 NA NA
MPL midostaurin 0.2151839 0.8075109 0.21518 NA NA
RAD21 temozolomide 0.2154867 0.8075109 0.21549 NA NA
AKT2 gefitinib 0.2158478 0.8075109 0.21585 NA NA
NPM1 erlotinib 0.2158617 0.8075109 0.21586 NA NA
BCORL1 bosutinib monohydrate 0.2167334 0.8081277 0.21673 NA NA
PTCH1 temozolomide 0.2167760 0.8081277 0.21678 NA NA
MAP2K1 crizotinib 0.2167899 0.8081277 0.21679 NA NA
DNAJB1 lapatinib 0.2180070 0.8105176 0.21801 NA NA
ESR1 belinostat 0.2186179 0.8105176 0.21862 NA NA
IL7R erlotinib 0.2186340 0.8105176 0.21863 NA NA
CTCF imatinib 0.2188316 0.8105176 0.21883 NA NA
SF1 pazopanib 0.2189633 0.8105176 0.21896 NA NA
MYCN ruxolitinib 0.2191911 0.8105176 0.21919 NA NA
MYD88 belinostat 0.2195610 0.8105176 0.21956 NA NA
IKZF1 midostaurin 0.2196854 0.8105176 0.21969 NA NA
GATA2 erlotinib 0.2198677 0.8105176 0.21987 NA NA
BRCA1 vismodegib 0.2203270 0.8105176 0.22033 NA NA
CBLB trametinib 0.2206325 0.8105176 0.22063 NA NA
NOTCH2 dasatinib 0.2206354 0.8105176 0.22064 NA NA
SMC1A lapatinib 0.2210226 0.8105176 0.22102 NA NA
PML temozolomide 0.2217712 0.8105176 0.22177 NA NA
CEBPA palbociclib 0.2217988 0.8105176 0.22180 NA NA
PTPN11 midostaurin 0.2220450 0.8105176 0.22204 NA NA
NT5C2 nilotinib 0.2223316 0.8105176 0.22233 NA NA
PAX5 imatinib 0.2228977 0.8105176 0.22290 NA NA
CEBPA alectinib 0.2230121 0.8105176 0.22301 NA NA
PDGFB vismodegib 0.2233811 0.8105176 0.22338 NA NA
ROS1 belinostat 0.2235080 0.8105176 0.22351 NA NA
MDM2 midostaurin 0.2236312 0.8105176 0.22363 NA NA
KRAS tretinoin 0.2237016 0.8105176 0.22370 NA NA
CDK4 lapatinib 0.2244316 0.8105176 0.22443 NA NA
NPM1 alectinib 0.2246258 0.8105176 0.22463 NA NA
U2AF1 trametinib 0.2247977 0.8105176 0.22480 NA NA
NT5C2 cabozantinib 0.2249494 0.8105176 0.22495 NA NA
HRAS cabozantinib 0.2251053 0.8105176 0.22511 NA NA
TET2 lapatinib 0.2251236 0.8105176 0.22512 NA NA
RIT1 erlotinib 0.2253417 0.8105176 0.22534 NA NA
RIT1 lapatinib 0.2253423 0.8105176 0.22534 NA NA
DNMT3A dasatinib 0.2260896 0.8116726 0.22609 NA NA
SMC1A erlotinib 0.2261745 0.8116726 0.22617 NA NA
TET2 tretinoin 0.2269477 0.8135281 0.22695 NA NA
NOTCH1 vismodegib 0.2273665 0.8141105 0.22737 NA NA
DDIT3 palbociclib 0.2290040 0.8157603 0.22900 NA NA
RIT1 alectinib 0.2291396 0.8157603 0.22914 NA NA
TP53 ruxolitinib 0.2293455 0.8157603 0.22935 NA NA
ALK ruxolitinib 0.2294413 0.8157603 0.22944 NA NA
FGFR3 trametinib 0.2295042 0.8157603 0.22950 NA NA
PDGFB afatinib 0.2297013 0.8157603 0.22970 NA NA
PAX5 bosutinib monohydrate 0.2299628 0.8157603 0.22996 NA NA
PTEN sunitinib 0.2301212 0.8157603 0.23012 NA NA
MPL temozolomide 0.2305412 0.8157603 0.23054 NA NA
NRAS ruxolitinib 0.2306461 0.8157603 0.23065 NA NA
FANCL erlotinib 0.2309123 0.8157603 0.23091 NA NA
GNAQ dabrafenib 0.2310189 0.8157603 0.23102 NA NA
DPYD ponatinib 0.2315390 0.8157603 0.23154 NA NA
GATA1 midostaurin 0.2317022 0.8157603 0.23170 NA NA
CEBPA ruxolitinib 0.2318168 0.8157603 0.23182 NA NA
FANCL nilotinib 0.2322908 0.8157603 0.23229 NA NA
G6PD ruxolitinib 0.2325984 0.8157603 0.23260 NA NA
KIT vismodegib 0.2326739 0.8157603 0.23267 NA NA
BCORL1 ponatinib 0.2327074 0.8157603 0.23271 NA NA
PDCD1 bosutinib monohydrate 0.2330839 0.8161792 0.23308 NA NA
ROS1 alectinib 0.2335276 0.8162872 0.23353 NA NA
ATM sunitinib 0.2338151 0.8162872 0.23382 NA NA
PDCD1 alectinib 0.2338858 0.8162872 0.23389 NA NA
ABL1 lapatinib 0.2342922 0.8168079 0.23429 NA NA
SF3B1 vismodegib 0.2348374 0.8170790 0.23484 NA NA
GATA3 sunitinib 0.2349335 0.8170790 0.23493 NA NA
CTCF rucaparib 0.2351418 0.8170790 0.23514 NA NA
NT5C2 tretinoin 0.2358069 0.8184948 0.23581 NA NA
FBXW7 dasatinib 0.2361556 0.8186906 0.23616 NA NA
WT1 gefitinib 0.2363973 0.8186906 0.23640 NA NA
IL7R midostaurin 0.2368814 0.8186906 0.23688 NA NA
SSX1 pazopanib 0.2368944 0.8186906 0.23689 NA NA
PTCH1 belinostat 0.2376997 0.8205806 0.23770 NA NA
GNAS sunitinib 0.2380488 0.8208594 0.23805 NA NA
JAK2 alectinib 0.2385373 0.8208594 0.23854 NA NA
FANCL crizotinib 0.2386699 0.8208594 0.23867 NA NA
MGMT palbociclib 0.2389195 0.8208594 0.23892 NA NA
TSC2 alectinib 0.2393143 0.8208594 0.23931 NA NA
BCORL1 pazopanib 0.2394178 0.8208594 0.23942 NA NA
GATA1 imatinib 0.2395896 0.8208594 0.23959 NA NA
HRAS nilotinib 0.2403406 0.8225451 0.24034 NA NA
RIT1 palbociclib 0.2411715 0.8232292 0.24117 NA NA
NT5C2 dasatinib 0.2417207 0.8232292 0.24172 NA NA
CREBBP trametinib 0.2417435 0.8232292 0.24174 NA NA
CXCR4 dabrafenib 0.2424069 0.8232292 0.24241 NA NA
CYP19A1 trametinib 0.2426959 0.8232292 0.24270 NA NA
MDM2 afatinib 0.2429813 0.8232292 0.24298 NA NA
VHL alectinib 0.2439120 0.8232292 0.24391 NA NA
CTCF cabozantinib 0.2443216 0.8232292 0.24432 NA NA
G6PD dabrafenib 0.2443393 0.8232292 0.24434 NA NA
AKT2 tretinoin 0.2446468 0.8232292 0.24465 NA NA
CBLB ruxolitinib 0.2446656 0.8232292 0.24467 NA NA
SMC3 vismodegib 0.2452829 0.8232292 0.24528 NA NA
SH2B3 dabrafenib 0.2453136 0.8232292 0.24531 NA NA
EGF bosutinib monohydrate 0.2453569 0.8232292 0.24536 NA NA
FGFR2 temozolomide 0.2455699 0.8232292 0.24557 NA NA
DPYD trametinib 0.2458254 0.8232292 0.24583 NA NA
G6PD vismodegib 0.2460143 0.8232292 0.24601 NA NA
EGF docetaxel 0.2461603 0.8232292 0.24616 NA NA
CBLB bosutinib monohydrate 0.2461824 0.8232292 0.24618 NA NA
PDCD1 cabozantinib 0.2464043 0.8232292 0.24640 NA NA
ABL1 alectinib 0.2470177 0.8232292 0.24702 NA NA
GATA3 imatinib 0.2473162 0.8232292 0.24732 NA NA
TSC1 vismodegib 0.2476631 0.8232292 0.24766 NA NA
IDH2 bosutinib monohydrate 0.2477175 0.8232292 0.24772 NA NA
CTNNB1 bosutinib monohydrate 0.2477885 0.8232292 0.24779 NA NA
GNA11 docetaxel 0.2485190 0.8232292 0.24852 NA NA
ERBB3 tretinoin 0.2487626 0.8232292 0.24876 NA NA
NPM1 docetaxel 0.2488101 0.8232292 0.24881 NA NA
RAD21 rucaparib 0.2491994 0.8232292 0.24920 NA NA
RET trametinib 0.2493948 0.8232292 0.24939 NA NA
RAD21 palbociclib 0.2494293 0.8232292 0.24943 NA NA
KRAS ponatinib 0.2496849 0.8232292 0.24968 NA NA
BTK afatinib 0.2500025 0.8232292 0.25000 NA NA
NRAS palbociclib 0.2500055 0.8232292 0.25001 NA NA
ASXL1 dasatinib 0.2501299 0.8232292 0.25013 NA NA
PDGFB imatinib 0.2502352 0.8232292 0.25024 NA NA
XPO1 belinostat 0.2503343 0.8232292 0.25033 NA NA
CRLF2 pazopanib 0.2509570 0.8232292 0.25096 NA NA
AKT2 ponatinib 0.2512025 0.8232292 0.25120 NA NA
JAK1 vismodegib 0.2513278 0.8232292 0.25133 NA NA
CALR lapatinib 0.2514271 0.8232292 0.25143 NA NA
MGMT lapatinib 0.2514271 0.8232292 0.25143 NA NA
MPL crizotinib 0.2519796 0.8239178 0.25198 NA NA
ERBB2 dabrafenib 0.2521562 0.8239178 0.25216 NA NA
PML dabrafenib 0.2532744 0.8255685 0.25327 NA NA
HRAS tretinoin 0.2537166 0.8255685 0.25372 NA NA
EGFR dasatinib 0.2539632 0.8255685 0.25396 NA NA
CALR imatinib 0.2539993 0.8255685 0.25400 NA NA
AKT2 erlotinib 0.2541238 0.8255685 0.25412 NA NA
BRCA1 bosutinib monohydrate 0.2550079 0.8255685 0.25501 NA NA
BRCA2 afatinib 0.2553180 0.8255685 0.25532 NA NA
DNAJB1 midostaurin 0.2553242 0.8255685 0.25532 NA NA
EML4 rucaparib 0.2555029 0.8255685 0.25550 NA NA
EGF cabozantinib 0.2557242 0.8255685 0.25572 NA NA
CTLA4 afatinib 0.2557520 0.8255685 0.25575 NA NA
IDH1 docetaxel 0.2558126 0.8255685 0.25581 NA NA
PML sunitinib 0.2560406 0.8255685 0.25604 NA NA
MAP2K2 vismodegib 0.2563401 0.8256959 0.25634 NA NA
TP53 temozolomide 0.2572528 0.8275374 0.25725 NA NA
PHF6 gefitinib 0.2574329 0.8275374 0.25743 NA NA
HRAS belinostat 0.2579401 0.8276485 0.25794 NA NA
CD274 midostaurin 0.2584055 0.8276485 0.25841 NA NA
TSC2 palbociclib 0.2593090 0.8276485 0.25931 NA NA
RUNX1 rucaparib 0.2593719 0.8276485 0.25937 NA NA
SH2B3 afatinib 0.2597980 0.8276485 0.25980 NA NA
CALR tretinoin 0.2599107 0.8276485 0.25991 NA NA
ERBB4 afatinib 0.2599147 0.8276485 0.25991 NA NA
CDKN2A alectinib 0.2605683 0.8276485 0.26057 NA NA
SF3B1 afatinib 0.2607779 0.8276485 0.26078 NA NA
IDH2 ponatinib 0.2610616 0.8276485 0.26106 NA NA
ERBB4 imatinib 0.2611044 0.8276485 0.26110 NA NA
STAT3 dasatinib 0.2617061 0.8276485 0.26171 NA NA
CSF3R midostaurin 0.2617885 0.8276485 0.26179 NA NA
PTCH1 ponatinib 0.2619913 0.8276485 0.26199 NA NA
GATA2 dasatinib 0.2620633 0.8276485 0.26206 NA NA
UGT1A1 crizotinib 0.2625570 0.8276485 0.26256 NA NA
NOTCH1 dasatinib 0.2625738 0.8276485 0.26257 NA NA
TPMT docetaxel 0.2626723 0.8276485 0.26267 NA NA
BCOR rucaparib 0.2627595 0.8276485 0.26276 NA NA
PTCH1 afatinib 0.2628105 0.8276485 0.26281 NA NA
PDGFB lapatinib 0.2633229 0.8276485 0.26332 NA NA
CDKN2A gefitinib 0.2634206 0.8276485 0.26342 NA NA
PDCD1 ruxolitinib 0.2638283 0.8276485 0.26383 NA NA
CEBPA vismodegib 0.2638745 0.8276485 0.26387 NA NA
DNMT3A afatinib 0.2639824 0.8276485 0.26398 NA NA
U2AF1 nilotinib 0.2644922 0.8284294 0.26449 NA NA
TPMT vismodegib 0.2650075 0.8286589 0.26501 NA NA
SETD2 vismodegib 0.2650874 0.8286589 0.26509 NA NA
U2AF1 ponatinib 0.2666179 0.8315214 0.26662 NA NA
BRAF docetaxel 0.2666895 0.8315214 0.26669 NA NA
NRAS dabrafenib 0.2669909 0.8315214 0.26699 NA NA
MGMT midostaurin 0.2670503 0.8315214 0.26705 NA NA
ZRSR2 docetaxel 0.2674973 0.8317549 0.26750 NA NA
DNAJB1 crizotinib 0.2676694 0.8317549 0.26767 NA NA
PIGA pazopanib 0.2681396 0.8317549 0.26814 NA NA
PIGA rucaparib 0.2683194 0.8317549 0.26832 NA NA
DNMT3A cabozantinib 0.2687536 0.8317549 0.26875 NA NA
TP53 pazopanib 0.2688657 0.8317549 0.26887 NA NA
DPYD dabrafenib 0.2691497 0.8317549 0.26915 NA NA
SETD2 imatinib 0.2695411 0.8317549 0.26954 NA NA
JAK3 belinostat 0.2699558 0.8317549 0.26996 NA NA
JAK2 tretinoin 0.2702044 0.8317549 0.27020 NA NA
FANCL palbociclib 0.2705871 0.8317549 0.27059 NA NA
EGFR alectinib 0.2707820 0.8317549 0.27078 NA NA
AR ruxolitinib 0.2707866 0.8317549 0.27079 NA NA
STAT3 sunitinib 0.2711355 0.8317549 0.27114 NA NA
ALK belinostat 0.2712457 0.8317549 0.27125 NA NA
TP53 ponatinib 0.2715421 0.8317549 0.27154 NA NA
GATA1 cabozantinib 0.2722065 0.8317549 0.27221 NA NA
AKT1 vismodegib 0.2724738 0.8317549 0.27247 NA NA
KRAS docetaxel 0.2725554 0.8317549 0.27256 NA NA
RAD21 trametinib 0.2729462 0.8317549 0.27295 NA NA
NPM1 lapatinib 0.2737483 0.8317549 0.27375 NA NA
TPMT nilotinib 0.2737875 0.8317549 0.27379 NA NA
PDGFRB nilotinib 0.2738696 0.8317549 0.27387 NA NA
ERBB2 trametinib 0.2740267 0.8317549 0.27403 NA NA
CDC73 afatinib 0.2743006 0.8317549 0.27430 NA NA
SMC1A bosutinib monohydrate 0.2743651 0.8317549 0.27437 NA NA
NCOA2 rucaparib 0.2744830 0.8317549 0.27448 NA NA
MAP2K2 gefitinib 0.2745244 0.8317549 0.27452 NA NA
NPM1 temozolomide 0.2747200 0.8317549 0.27472 NA NA
PDGFB nilotinib 0.2752114 0.8320379 0.27521 NA NA
RIT1 bosutinib monohydrate 0.2754670 0.8320379 0.27547 NA NA
EML4 bosutinib monohydrate 0.2755994 0.8320379 0.27560 NA NA
RUNX1 cabozantinib 0.2760789 0.8326939 0.27608 NA NA
DNAJB1 bosutinib monohydrate 0.2768690 0.8342846 0.27687 NA NA
TET2 midostaurin 0.2773549 0.8343796 0.27735 NA NA
EZH2 docetaxel 0.2774451 0.8343796 0.27745 NA NA
SRSF2 afatinib 0.2781061 0.8343796 0.27811 NA NA
PTEN ponatinib 0.2782635 0.8343796 0.27826 NA NA
CBL gefitinib 0.2788384 0.8343796 0.27884 NA NA
CTLA4 docetaxel 0.2788643 0.8343796 0.27886 NA NA
AR crizotinib 0.2791398 0.8343796 0.27914 NA NA
PIGA afatinib 0.2792417 0.8343796 0.27924 NA NA
GNA11 midostaurin 0.2792650 0.8343796 0.27926 NA NA
JAK2 rucaparib 0.2799799 0.8351327 0.27998 NA NA
CD274 docetaxel 0.2805815 0.8351327 0.28058 NA NA
MDM2 alectinib 0.2810211 0.8351327 0.28102 NA NA
SRSF2 tretinoin 0.2812022 0.8351327 0.28120 NA NA
SRSF2 nilotinib 0.2812050 0.8351327 0.28120 NA NA
KIT ruxolitinib 0.2812051 0.8351327 0.28121 NA NA
JAK1 midostaurin 0.2818427 0.8351327 0.28184 NA NA
PDGFRB docetaxel 0.2818564 0.8351327 0.28186 NA NA
ERBB4 lapatinib 0.2819297 0.8351327 0.28193 NA NA
CSF3R dabrafenib 0.2822100 0.8351327 0.28221 NA NA
SF3B1 erlotinib 0.2824110 0.8351327 0.28241 NA NA
BCORL1 lapatinib 0.2829109 0.8351327 0.28291 NA NA
MPL docetaxel 0.2836659 0.8351327 0.28367 NA NA
RIT1 ponatinib 0.2845500 0.8351327 0.28455 NA NA
PHF6 dasatinib 0.2853231 0.8351327 0.28532 NA NA
PTEN palbociclib 0.2856346 0.8351327 0.28563 NA NA
CDK6 ruxolitinib 0.2857749 0.8351327 0.28577 NA NA
NCOA2 palbociclib 0.2859635 0.8351327 0.28596 NA NA
CD79B lapatinib 0.2864755 0.8351327 0.28648 NA NA
GNAQ lapatinib 0.2864755 0.8351327 0.28648 NA NA
JAK3 docetaxel 0.2865263 0.8351327 0.28653 NA NA
CXCR4 docetaxel 0.2866824 0.8351327 0.28668 NA NA
RIT1 nilotinib 0.2868250 0.8351327 0.28682 NA NA
PAX5 pazopanib 0.2868988 0.8351327 0.28690 NA NA
CXCR4 sunitinib 0.2869137 0.8351327 0.28691 NA NA
FGFR1 gefitinib 0.2872103 0.8351327 0.28721 NA NA
PDGFRA midostaurin 0.2883532 0.8351327 0.28835 NA NA
GNB1 bosutinib monohydrate 0.2886360 0.8351327 0.28864 NA NA
ERBB3 cabozantinib 0.2887403 0.8351327 0.28874 NA NA
CTNNB1 dabrafenib 0.2892579 0.8351327 0.28926 NA NA
ZRSR2 sunitinib 0.2895406 0.8351327 0.28954 NA NA
CDK6 midostaurin 0.2899976 0.8351327 0.29000 NA NA
MET palbociclib 0.2900431 0.8351327 0.29004 NA NA
MET vismodegib 0.2900560 0.8351327 0.29006 NA NA
FGFR3 dasatinib 0.2900699 0.8351327 0.29007 NA NA
GNB1 sunitinib 0.2903826 0.8351327 0.29038 NA NA
RAD21 erlotinib 0.2906403 0.8351327 0.29064 NA NA
CDK6 rucaparib 0.2907652 0.8351327 0.29077 NA NA
BRCA2 bosutinib monohydrate 0.2907814 0.8351327 0.29078 NA NA
CD79B alectinib 0.2908767 0.8351327 0.29088 NA NA
EML4 sunitinib 0.2909234 0.8351327 0.29092 NA NA
PIGA midostaurin 0.2909512 0.8351327 0.29095 NA NA
AKT3 tretinoin 0.2910595 0.8351327 0.29106 NA NA
CBL temozolomide 0.2912507 0.8351327 0.29125 NA NA
FANCL dasatinib 0.2913498 0.8351327 0.29135 NA NA
CDKN2A erlotinib 0.2916190 0.8351504 0.29162 NA NA
EGF ponatinib 0.2924029 0.8364196 0.29240 NA NA
KRAS midostaurin 0.2927354 0.8364196 0.29274 NA NA
SETBP1 pazopanib 0.2928522 0.8364196 0.29285 NA NA
CD274 dabrafenib 0.2936109 0.8370865 0.29361 NA NA
U2AF1 imatinib 0.2938112 0.8370865 0.29381 NA NA
CSF3R trametinib 0.2947229 0.8370865 0.29472 NA NA
CD79B sunitinib 0.2950346 0.8370865 0.29503 NA NA
GNAQ sunitinib 0.2950346 0.8370865 0.29503 NA NA
PTCH1 pazopanib 0.2950783 0.8370865 0.29508 NA NA
FANCL pazopanib 0.2951768 0.8370865 0.29518 NA NA
SETBP1 dabrafenib 0.2954170 0.8370865 0.29542 NA NA
AKT1 alectinib 0.2956410 0.8370865 0.29564 NA NA
UGT1A1 imatinib 0.2957214 0.8370865 0.29572 NA NA
ROS1 bosutinib monohydrate 0.2963370 0.8380823 0.29634 NA NA
CBL rucaparib 0.2974374 0.8390803 0.29744 NA NA
SMC1A temozolomide 0.2977471 0.8390803 0.29775 NA NA
FLT3 trametinib 0.2977892 0.8390803 0.29779 NA NA
XPO1 imatinib 0.2979122 0.8390803 0.29791 NA NA
BTK imatinib 0.2980109 0.8390803 0.29801 NA NA
FGFR1 alectinib 0.3000040 0.8431304 0.30000 NA NA
RIT1 gefitinib 0.3002316 0.8431304 0.30023 NA NA
MYCN docetaxel 0.3007324 0.8431304 0.30073 NA NA
JAK3 alectinib 0.3008462 0.8431304 0.30085 NA NA
ERBB4 dasatinib 0.3011735 0.8431304 0.30117 NA NA
ERBB2 tretinoin 0.3012993 0.8431304 0.30130 NA NA
PIGA temozolomide 0.3013076 0.8431304 0.30131 NA NA
XPO1 ruxolitinib 0.3027717 0.8464813 0.30277 NA NA
DNAJB1 temozolomide 0.3033881 0.8469194 0.30339 NA NA
SF3B1 rucaparib 0.3037310 0.8469194 0.30373 NA NA
GNAS vismodegib 0.3041539 0.8469194 0.30415 NA NA
AKT1 ruxolitinib 0.3044779 0.8469194 0.30448 NA NA
TSC1 ruxolitinib 0.3045736 0.8469194 0.30457 NA NA
DPYD cabozantinib 0.3047799 0.8469194 0.30478 NA NA
IDH2 pazopanib 0.3050404 0.8469194 0.30504 NA NA
ASXL1 trametinib 0.3050617 0.8469194 0.30506 NA NA
PRPF40B nilotinib 0.3059911 0.8479355 0.30599 NA NA
MDM2 dabrafenib 0.3064629 0.8479355 0.30646 NA NA
BTK trametinib 0.3064806 0.8479355 0.30648 NA NA
SF3B1 midostaurin 0.3064956 0.8479355 0.30650 NA NA
PAX8 bosutinib monohydrate 0.3070631 0.8487663 0.30706 NA NA
NOTCH1 bosutinib monohydrate 0.3085065 0.8511104 0.30851 NA NA
FBXW7 midostaurin 0.3089074 0.8511104 0.30891 NA NA
PTCH1 nilotinib 0.3093982 0.8511104 0.30940 NA NA
BCORL1 tretinoin 0.3097124 0.8511104 0.30971 NA NA
GNAS alectinib 0.3097168 0.8511104 0.30972 NA NA
BRAF tretinoin 0.3097622 0.8511104 0.30976 NA NA
XPO1 docetaxel 0.3105293 0.8511104 0.31053 NA NA
DPYD afatinib 0.3107947 0.8511104 0.31079 NA NA
TSC1 imatinib 0.3108496 0.8511104 0.31085 NA NA
MGMT rucaparib 0.3112521 0.8511104 0.31125 NA NA
BTK sunitinib 0.3113123 0.8511104 0.31131 NA NA
ERBB4 temozolomide 0.3115486 0.8511104 0.31155 NA NA
WHSC1 tretinoin 0.3115987 0.8511104 0.31160 NA NA
TPMT gefitinib 0.3116629 0.8511104 0.31166 NA NA
ERBB2 dasatinib 0.3121664 0.8514890 0.31217 NA NA
NT5C2 belinostat 0.3123377 0.8514890 0.31234 NA NA
VHL dasatinib 0.3136021 0.8530655 0.31360 NA NA
MET tretinoin 0.3136957 0.8530655 0.31370 NA NA
BRCA2 rucaparib 0.3140675 0.8530655 0.31407 NA NA
NRAS tretinoin 0.3141618 0.8530655 0.31416 NA NA
PDGFRA imatinib 0.3143676 0.8530655 0.31437 NA NA
CDK6 cabozantinib 0.3152330 0.8530655 0.31523 NA NA
GATA1 sunitinib 0.3154704 0.8530655 0.31547 NA NA
ESR1 rucaparib 0.3155348 0.8530655 0.31553 NA NA
KRAS belinostat 0.3158051 0.8530655 0.31581 NA NA
ERBB2 imatinib 0.3160344 0.8530655 0.31603 NA NA
CYP19A1 belinostat 0.3161498 0.8530655 0.31615 NA NA
SF1 docetaxel 0.3162400 0.8530655 0.31624 NA NA
CXCR4 nilotinib 0.3164078 0.8530655 0.31641 NA NA
SMO nilotinib 0.3168786 0.8533178 0.31688 NA NA
SF3B1 bosutinib monohydrate 0.3173562 0.8533178 0.31736 NA NA
KIT rucaparib 0.3176892 0.8533178 0.31769 NA NA
PTCH1 palbociclib 0.3180803 0.8533178 0.31808 NA NA
RIT1 crizotinib 0.3182654 0.8533178 0.31827 NA NA
SH2B3 tretinoin 0.3183595 0.8533178 0.31836 NA NA
MAP2K2 trametinib 0.3188070 0.8533178 0.31881 NA NA
CBLB lapatinib 0.3188445 0.8533178 0.31884 NA NA
SMC3 imatinib 0.3191465 0.8533178 0.31915 NA NA
SMC1A crizotinib 0.3195953 0.8533178 0.31960 NA NA
ZRSR2 nilotinib 0.3197215 0.8533178 0.31972 NA NA
NPM1 nilotinib 0.3197255 0.8533178 0.31973 NA NA
IL7R pazopanib 0.3205386 0.8544661 0.32054 NA NA
ROS1 rucaparib 0.3210092 0.8544661 0.32101 NA NA
FBXW7 lapatinib 0.3216173 0.8544661 0.32162 NA NA
EGF trametinib 0.3216768 0.8544661 0.32168 NA NA
PIK3CA nilotinib 0.3221612 0.8544661 0.32216 NA NA
RAD21 bosutinib monohydrate 0.3221870 0.8544661 0.32219 NA NA
FGFR3 docetaxel 0.3221893 0.8544661 0.32219 NA NA
CDC73 bosutinib monohydrate 0.3226723 0.8544661 0.32267 NA NA
TET2 bosutinib monohydrate 0.3227747 0.8544661 0.32277 NA NA
FGFR3 lapatinib 0.3229794 0.8544661 0.32298 NA NA
GATA1 temozolomide 0.3232634 0.8544661 0.32326 NA NA
SF1 alectinib 0.3234420 0.8544661 0.32344 NA NA
SMC1A midostaurin 0.3236533 0.8544661 0.32365 NA NA
FGFR2 midostaurin 0.3242790 0.8554070 0.32428 NA NA
DPYD vismodegib 0.3255816 0.8580773 0.32558 NA NA
IDH2 gefitinib 0.3258316 0.8580773 0.32583 NA NA
FLT3 gefitinib 0.3274937 0.8606691 0.32749 NA NA
CTCF ponatinib 0.3280080 0.8606691 0.32801 NA NA
MGMT dabrafenib 0.3282216 0.8606691 0.32822 NA NA
U2AF1 temozolomide 0.3282964 0.8606691 0.32830 NA NA
PIK3CA erlotinib 0.3286540 0.8606691 0.32865 NA NA
BCORL1 palbociclib 0.3287607 0.8606691 0.32876 NA NA
IDH2 docetaxel 0.3288933 0.8606691 0.32889 NA NA
FLCN cabozantinib 0.3290045 0.8606691 0.32900 NA NA
SSX1 alectinib 0.3293082 0.8606691 0.32931 NA NA
MAP2K2 ruxolitinib 0.3295676 0.8606691 0.32957 NA NA
NOTCH2 crizotinib 0.3297967 0.8606691 0.32980 NA NA
GNB1 ponatinib 0.3304650 0.8610009 0.33046 NA NA
PAX5 lapatinib 0.3307420 0.8610009 0.33074 NA NA
GATA1 alectinib 0.3310119 0.8610009 0.33101 NA NA
TSC2 lapatinib 0.3311360 0.8610009 0.33114 NA NA
EGFR midostaurin 0.3312793 0.8610009 0.33128 NA NA
ERBB2 nilotinib 0.3322155 0.8615524 0.33222 NA NA
WHSC1 erlotinib 0.3322629 0.8615524 0.33226 NA NA
PDGFB palbociclib 0.3327587 0.8615524 0.33276 NA NA
PRPF8 crizotinib 0.3336126 0.8615524 0.33361 NA NA
PIGA belinostat 0.3336508 0.8615524 0.33365 NA NA
JAK1 tretinoin 0.3338555 0.8615524 0.33386 NA NA
ROS1 nilotinib 0.3339538 0.8615524 0.33395 NA NA
ERBB3 gefitinib 0.3353927 0.8615524 0.33539 NA NA
AKT2 crizotinib 0.3358098 0.8615524 0.33581 NA NA
NT5C2 crizotinib 0.3358098 0.8615524 0.33581 NA NA
CD79B dasatinib 0.3359203 0.8615524 0.33592 NA NA
GNAQ dasatinib 0.3359203 0.8615524 0.33592 NA NA
PDCD1 dasatinib 0.3359203 0.8615524 0.33592 NA NA
IDH1 rucaparib 0.3365827 0.8615524 0.33658 NA NA
BRAF imatinib 0.3365852 0.8615524 0.33659 NA NA
SMC3 ruxolitinib 0.3368205 0.8615524 0.33682 NA NA
SETBP1 gefitinib 0.3370540 0.8615524 0.33705 NA NA
MET pazopanib 0.3375577 0.8615524 0.33756 NA NA
ERBB3 bosutinib monohydrate 0.3381914 0.8615524 0.33819 NA NA
BCORL1 nilotinib 0.3383996 0.8615524 0.33840 NA NA
MPL afatinib 0.3387786 0.8615524 0.33878 NA NA
CTCF erlotinib 0.3389875 0.8615524 0.33899 NA NA
BCOR temozolomide 0.3390158 0.8615524 0.33902 NA NA
SH2B3 nilotinib 0.3391378 0.8615524 0.33914 NA NA
GNAS rucaparib 0.3392393 0.8615524 0.33924 NA NA
SRSF2 cabozantinib 0.3392737 0.8615524 0.33927 NA NA
RET vismodegib 0.3393340 0.8615524 0.33933 NA NA
CD274 vismodegib 0.3393363 0.8615524 0.33934 NA NA
CDK4 gefitinib 0.3394024 0.8615524 0.33940 NA NA
ERBB2 pazopanib 0.3398016 0.8615524 0.33980 NA NA
PDGFRB rucaparib 0.3399009 0.8615524 0.33990 NA NA
CEBPA bosutinib monohydrate 0.3405298 0.8624581 0.34053 NA NA
IKZF1 imatinib 0.3413302 0.8633688 0.34133 NA NA
NRAS ponatinib 0.3414906 0.8633688 0.34149 NA NA
STAG2 vismodegib 0.3420418 0.8633688 0.34204 NA NA
GNAQ bosutinib monohydrate 0.3420516 0.8633688 0.34205 NA NA
MYD88 rucaparib 0.3422485 0.8633688 0.34225 NA NA
PDGFRB vismodegib 0.3432087 0.8651040 0.34321 NA NA
KMT2A alectinib 0.3437441 0.8656743 0.34374 NA NA
GNB1 belinostat 0.3441703 0.8656743 0.34417 NA NA
BTK tretinoin 0.3447531 0.8656743 0.34475 NA NA
BTK alectinib 0.3449044 0.8656743 0.34490 NA NA
DPYD rucaparib 0.3449122 0.8656743 0.34491 NA NA
DPYD dasatinib 0.3450704 0.8656743 0.34507 NA NA
WHSC1 nilotinib 0.3455546 0.8662048 0.34555 NA NA
RAD21 pazopanib 0.3462781 0.8673337 0.34628 NA NA
CTCF belinostat 0.3467750 0.8677536 0.34678 NA NA
NCOA2 nilotinib 0.3469922 0.8677536 0.34699 NA NA
BRCA1 alectinib 0.3475727 0.8678703 0.34757 NA NA
MET bosutinib monohydrate 0.3480988 0.8678703 0.34810 NA NA
SF1 erlotinib 0.3481404 0.8678703 0.34814 NA NA
IDH2 tretinoin 0.3482943 0.8678703 0.34829 NA NA
ATM temozolomide 0.3484051 0.8678703 0.34841 NA NA
AR trametinib 0.3489364 0.8685125 0.34894 NA NA
EZH2 belinostat 0.3495023 0.8690733 0.34950 NA NA
EGF dasatinib 0.3499723 0.8690733 0.34997 NA NA
BRCA2 belinostat 0.3501637 0.8690733 0.35016 NA NA
PRPF8 gefitinib 0.3503421 0.8690733 0.35034 NA NA
PTPN11 docetaxel 0.3505582 0.8690733 0.35056 NA NA
CDK4 docetaxel 0.3512258 0.8690733 0.35123 NA NA
GATA1 dasatinib 0.3512636 0.8690733 0.35126 NA NA
NRAS crizotinib 0.3513508 0.8690733 0.35135 NA NA
CEBPA trametinib 0.3520319 0.8700805 0.35203 NA NA
GATA1 pazopanib 0.3523703 0.8702394 0.35237 NA NA
EGF nilotinib 0.3526555 0.8702671 0.35266 NA NA
SMC3 palbociclib 0.3538314 0.8719506 0.35383 NA NA
CDK4 dabrafenib 0.3540843 0.8719506 0.35408 NA NA
STAG2 bosutinib monohydrate 0.3541613 0.8719506 0.35416 NA NA
SETD2 nilotinib 0.3549033 0.8725188 0.35490 NA NA
TET2 gefitinib 0.3552137 0.8725188 0.35521 NA NA
PDCD1 erlotinib 0.3556069 0.8725188 0.35561 NA NA
G6PD ponatinib 0.3562978 0.8725188 0.35630 NA NA
GATA1 rucaparib 0.3564121 0.8725188 0.35641 NA NA
CYP19A1 alectinib 0.3564980 0.8725188 0.35650 NA NA
CBL nilotinib 0.3567703 0.8725188 0.35677 NA NA
PIGA crizotinib 0.3571747 0.8725188 0.35717 NA NA
DNMT3A vismodegib 0.3575484 0.8725188 0.35755 NA NA
ERBB4 trametinib 0.3576230 0.8725188 0.35762 NA NA
PTCH1 docetaxel 0.3578141 0.8725188 0.35781 NA NA
BRAF nilotinib 0.3579029 0.8725188 0.35790 NA NA
KIT afatinib 0.3580267 0.8725188 0.35803 NA NA
IKZF1 erlotinib 0.3582382 0.8725188 0.35824 NA NA
SETBP1 afatinib 0.3588256 0.8728730 0.35883 NA NA
MET sunitinib 0.3589333 0.8728730 0.35893 NA NA
BRAF pazopanib 0.3592410 0.8729529 0.35924 NA NA
GATA2 cabozantinib 0.3602779 0.8746924 0.36028 NA NA
KMT2A imatinib 0.3610200 0.8746924 0.36102 NA NA
TP53 nilotinib 0.3614059 0.8746924 0.36141 NA NA
MDM2 sunitinib 0.3616422 0.8746924 0.36164 NA NA
MPL rucaparib 0.3616444 0.8746924 0.36164 NA NA
AKT3 ponatinib 0.3621735 0.8746924 0.36217 NA NA
CXCR4 afatinib 0.3626374 0.8746924 0.36264 NA NA
STAG2 crizotinib 0.3627363 0.8746924 0.36274 NA NA
PDGFB gefitinib 0.3627861 0.8746924 0.36279 NA NA
BRCA2 pazopanib 0.3630866 0.8746924 0.36309 NA NA
PAX5 vismodegib 0.3631253 0.8746924 0.36313 NA NA
PAX5 dasatinib 0.3632617 0.8746924 0.36326 NA NA
AR cabozantinib 0.3642750 0.8754019 0.36427 NA NA
SSX1 gefitinib 0.3647486 0.8754019 0.36475 NA NA
AKT3 lapatinib 0.3649345 0.8754019 0.36493 NA NA
IDH1 lapatinib 0.3649345 0.8754019 0.36493 NA NA
MYCN lapatinib 0.3649345 0.8754019 0.36493 NA NA
XPO1 erlotinib 0.3661029 0.8770653 0.36610 NA NA
IKZF1 crizotinib 0.3663689 0.8770653 0.36637 NA NA
CTCF alectinib 0.3665010 0.8770653 0.36650 NA NA
BCOR vismodegib 0.3669291 0.8770653 0.36693 NA NA
PDGFRB lapatinib 0.3673411 0.8770653 0.36734 NA NA
TSC1 lapatinib 0.3673411 0.8770653 0.36734 NA NA
PTEN crizotinib 0.3676751 0.8770653 0.36768 NA NA
MAP2K2 dabrafenib 0.3682429 0.8770653 0.36824 NA NA
CDKN2A temozolomide 0.3683127 0.8770653 0.36831 NA NA
TSC1 pazopanib 0.3683895 0.8770653 0.36839 NA NA
XPO1 sunitinib 0.3697335 0.8794232 0.36973 NA NA
ALK crizotinib 0.3700920 0.8794232 0.37009 NA NA
ATM nilotinib 0.3703913 0.8794232 0.37039 NA NA
TSC1 palbociclib 0.3704875 0.8794232 0.37049 NA NA
ASXL1 ruxolitinib 0.3708094 0.8795300 0.37081 NA NA
FANCL afatinib 0.3712677 0.8796559 0.37127 NA NA
NPM1 crizotinib 0.3719543 0.8796559 0.37195 NA NA
RUNX1 trametinib 0.3720382 0.8796559 0.37204 NA NA
BCORL1 docetaxel 0.3721966 0.8796559 0.37220 NA NA
FGFR2 crizotinib 0.3724916 0.8796559 0.37249 NA NA
SMO palbociclib 0.3726724 0.8796559 0.37267 NA NA
G6PD palbociclib 0.3728013 0.8796559 0.37280 NA NA
SH2B3 midostaurin 0.3733494 0.8801498 0.37335 NA NA
SF1 afatinib 0.3735649 0.8801498 0.37356 NA NA
PRPF40B trametinib 0.3750237 0.8829320 0.37502 NA NA
PIGA trametinib 0.3753941 0.8830149 0.37539 NA NA
ATM lapatinib 0.3757531 0.8830149 0.37575 NA NA
ASXL1 afatinib 0.3758930 0.8830149 0.37589 NA NA
SRSF2 rucaparib 0.3768031 0.8838700 0.37680 NA NA
SF1 dasatinib 0.3774403 0.8838700 0.37744 NA NA
RIT1 tretinoin 0.3778288 0.8838700 0.37783 NA NA
NCOA2 dabrafenib 0.3782220 0.8838700 0.37822 NA NA
ERBB2 ruxolitinib 0.3785733 0.8838700 0.37857 NA NA
IL7R belinostat 0.3785808 0.8838700 0.37858 NA NA
MAP2K1 cabozantinib 0.3789920 0.8838700 0.37899 NA NA
PDGFB dasatinib 0.3792939 0.8838700 0.37929 NA NA
GNA11 gefitinib 0.3799164 0.8838700 0.37992 NA NA
MPL tretinoin 0.3802579 0.8838700 0.38026 NA NA
KRAS dasatinib 0.3806744 0.8838700 0.38067 NA NA
BCORL1 dasatinib 0.3812942 0.8838700 0.38129 NA NA
NPM1 bosutinib monohydrate 0.3813570 0.8838700 0.38136 NA NA
SMO afatinib 0.3813865 0.8838700 0.38139 NA NA
STAG2 midostaurin 0.3813979 0.8838700 0.38140 NA NA
MDM2 ponatinib 0.3814458 0.8838700 0.38145 NA NA
PAX5 docetaxel 0.3815151 0.8838700 0.38152 NA NA
G6PD nilotinib 0.3817505 0.8838700 0.38175 NA NA
WHSC1 imatinib 0.3820492 0.8838700 0.38205 NA NA
DPYD temozolomide 0.3822258 0.8838700 0.38223 NA NA
MDM2 temozolomide 0.3822745 0.8838700 0.38227 NA NA
ATM pazopanib 0.3827853 0.8838700 0.38279 NA NA
ERBB2 bosutinib monohydrate 0.3828642 0.8838700 0.38286 NA NA
AKT3 sunitinib 0.3829361 0.8838700 0.38294 NA NA
PTCH1 alectinib 0.3832319 0.8839104 0.38323 NA NA
PIK3CA dasatinib 0.3837150 0.8843823 0.38371 NA NA
CXCR4 ruxolitinib 0.3846942 0.8857204 0.38469 NA NA
BRCA2 gefitinib 0.3852457 0.8857204 0.38525 NA NA
MDM2 bosutinib monohydrate 0.3854602 0.8857204 0.38546 NA NA
FGFR3 vismodegib 0.3855608 0.8857204 0.38556 NA NA
IKZF1 vismodegib 0.3859382 0.8857204 0.38594 NA NA
ATM afatinib 0.3862525 0.8857204 0.38625 NA NA
CDK6 erlotinib 0.3864721 0.8857204 0.38647 NA NA
AR midostaurin 0.3869180 0.8857204 0.38692 NA NA
PAX8 alectinib 0.3871065 0.8857204 0.38711 NA NA
CSF3R crizotinib 0.3873438 0.8857204 0.38734 NA NA
RAD21 sunitinib 0.3873632 0.8857204 0.38736 NA NA
CTCF nilotinib 0.3876743 0.8857940 0.38767 NA NA
RET imatinib 0.3884249 0.8865142 0.38842 NA NA
DNAJB1 pazopanib 0.3887892 0.8865142 0.38879 NA NA
SMO imatinib 0.3890402 0.8865142 0.38904 NA NA
ERBB3 belinostat 0.3891061 0.8865142 0.38911 NA NA
WT1 dabrafenib 0.3899972 0.8869513 0.39000 NA NA
SETBP1 ponatinib 0.3902213 0.8869513 0.39022 NA NA
BCORL1 sunitinib 0.3905032 0.8869513 0.39050 NA NA
CTCF dabrafenib 0.3923327 0.8869513 0.39233 NA NA
FGFR1 sunitinib 0.3924162 0.8869513 0.39242 NA NA
BRCA1 dasatinib 0.3928660 0.8869513 0.39287 NA NA
PHF6 lapatinib 0.3938211 0.8869513 0.39382 NA NA
ESR1 vismodegib 0.3942862 0.8869513 0.39429 NA NA
AKT3 erlotinib 0.3944367 0.8869513 0.39444 NA NA
IDH1 erlotinib 0.3944367 0.8869513 0.39444 NA NA
MYCN erlotinib 0.3944367 0.8869513 0.39444 NA NA
U2AF1 erlotinib 0.3944367 0.8869513 0.39444 NA NA
AKT1 tretinoin 0.3944562 0.8869513 0.39446 NA NA
ALK dasatinib 0.3952274 0.8869513 0.39523 NA NA
BTK gefitinib 0.3953704 0.8869513 0.39537 NA NA
TSC1 alectinib 0.3956481 0.8869513 0.39565 NA NA
DNAJB1 gefitinib 0.3961625 0.8869513 0.39616 NA NA
AKT1 palbociclib 0.3961746 0.8869513 0.39617 NA NA
PTEN vismodegib 0.3964159 0.8869513 0.39642 NA NA
GATA1 nilotinib 0.3965339 0.8869513 0.39653 NA NA
CYP19A1 nilotinib 0.3966596 0.8869513 0.39666 NA NA
SMC1A cabozantinib 0.3971299 0.8869513 0.39713 NA NA
DDIT3 belinostat 0.3972274 0.8869513 0.39723 NA NA
MET gefitinib 0.3977576 0.8869513 0.39776 NA NA
ASXL1 erlotinib 0.3979892 0.8869513 0.39799 NA NA
IL7R bosutinib monohydrate 0.3981162 0.8869513 0.39812 NA NA
WT1 tretinoin 0.3981599 0.8869513 0.39816 NA NA
JAK3 gefitinib 0.3982969 0.8869513 0.39830 NA NA
UGT1A1 pazopanib 0.3984406 0.8869513 0.39844 NA NA
JAK3 tretinoin 0.3985742 0.8869513 0.39857 NA NA
SF1 nilotinib 0.3986195 0.8869513 0.39862 NA NA
RUNX1 ponatinib 0.3986659 0.8869513 0.39867 NA NA
IKZF1 trametinib 0.3988024 0.8869513 0.39880 NA NA
DDIT3 trametinib 0.3990678 0.8869513 0.39907 NA NA
UGT1A1 sunitinib 0.3992388 0.8869513 0.39924 NA NA
STAG2 afatinib 0.3995949 0.8869513 0.39959 NA NA
NPM1 palbociclib 0.3996308 0.8869513 0.39963 NA NA
AKT2 docetaxel 0.4005242 0.8874480 0.40052 NA NA
ALK temozolomide 0.4005886 0.8874480 0.40059 NA NA
KIT erlotinib 0.4010455 0.8874480 0.40105 NA NA
IDH2 crizotinib 0.4011464 0.8874480 0.40115 NA NA
PDCD1 lapatinib 0.4012535 0.8874480 0.40125 NA NA
PDGFRA rucaparib 0.4016231 0.8874480 0.40162 NA NA
FGFR1 temozolomide 0.4020141 0.8874480 0.40201 NA NA
SETD2 lapatinib 0.4021077 0.8874480 0.40211 NA NA
AKT2 alectinib 0.4024812 0.8874480 0.40248 NA NA
ATM imatinib 0.4026488 0.8874480 0.40265 NA NA
BCORL1 cabozantinib 0.4040076 0.8888187 0.40401 NA NA
ERBB4 alectinib 0.4041032 0.8888187 0.40410 NA NA
UGT1A1 belinostat 0.4041103 0.8888187 0.40411 NA NA
BRCA1 erlotinib 0.4046403 0.8893687 0.40464 NA NA
EZH2 gefitinib 0.4053278 0.8900186 0.40533 NA NA
TP53 imatinib 0.4057119 0.8900186 0.40571 NA NA
PDGFB docetaxel 0.4060325 0.8900186 0.40603 NA NA
VHL nilotinib 0.4061768 0.8900186 0.40618 NA NA
CTNNB1 trametinib 0.4064703 0.8900186 0.40647 NA NA
PIK3CA belinostat 0.4072121 0.8900186 0.40721 NA NA
RUNX1 nilotinib 0.4072745 0.8900186 0.40727 NA NA
WT1 palbociclib 0.4072870 0.8900186 0.40729 NA NA
CD274 tretinoin 0.4075623 0.8900186 0.40756 NA NA
PML tretinoin 0.4081601 0.8900186 0.40816 NA NA
DNMT3A ruxolitinib 0.4082055 0.8900186 0.40821 NA NA
PDGFRA palbociclib 0.4083491 0.8900186 0.40835 NA NA
JAK3 dabrafenib 0.4085791 0.8900186 0.40858 NA NA
DDIT3 ponatinib 0.4091577 0.8906682 0.40916 NA NA
ASXL1 cabozantinib 0.4107168 0.8921233 0.41072 NA NA
IDH2 trametinib 0.4108540 0.8921233 0.41085 NA NA
SMO ruxolitinib 0.4108655 0.8921233 0.41087 NA NA
GATA3 vismodegib 0.4109497 0.8921233 0.41095 NA NA
NOTCH2 ruxolitinib 0.4112888 0.8922494 0.41129 NA NA
TP53 vismodegib 0.4116935 0.8925177 0.41169 NA NA
CEBPA afatinib 0.4120008 0.8925747 0.41200 NA NA
FGFR3 crizotinib 0.4127192 0.8927858 0.41272 NA NA
RET lapatinib 0.4130391 0.8927858 0.41304 NA NA
PIK3CA sunitinib 0.4133331 0.8927858 0.41333 NA NA
ASXL1 gefitinib 0.4134771 0.8927858 0.41348 NA NA
WHSC1 ponatinib 0.4135038 0.8927858 0.41350 NA NA
FLCN dasatinib 0.4143515 0.8935561 0.41435 NA NA
RIT1 vismodegib 0.4144232 0.8935561 0.41442 NA NA
CDC73 cabozantinib 0.4149638 0.8941147 0.41496 NA NA
FGFR3 dabrafenib 0.4155330 0.8946143 0.41553 NA NA
BRCA1 trametinib 0.4159320 0.8946143 0.41593 NA NA
EML4 ponatinib 0.4160407 0.8946143 0.41604 NA NA
DNMT3A trametinib 0.4166812 0.8948884 0.41668 NA NA
PDCD1 pazopanib 0.4167317 0.8948884 0.41673 NA NA
BTK ponatinib 0.4171885 0.8952639 0.41719 NA NA
PDGFRA bosutinib monohydrate 0.4175132 0.8953557 0.41751 NA NA
IKZF1 docetaxel 0.4191295 0.8982155 0.41913 NA NA
GNA11 nilotinib 0.4200233 0.8992814 0.42002 NA NA
MDM2 trametinib 0.4203066 0.8992814 0.42031 NA NA
PTPN11 palbociclib 0.4211924 0.8992814 0.42119 NA NA
BCOR gefitinib 0.4214414 0.8992814 0.42144 NA NA
ZRSR2 bosutinib monohydrate 0.4214919 0.8992814 0.42149 NA NA
MYD88 alectinib 0.4215902 0.8992814 0.42159 NA NA
AKT3 cabozantinib 0.4216866 0.8992814 0.42169 NA NA
ASXL1 bosutinib monohydrate 0.4226760 0.8992814 0.42268 NA NA
SMC3 belinostat 0.4229260 0.8992814 0.42293 NA NA
BRCA1 nilotinib 0.4230452 0.8992814 0.42305 NA NA
PRPF40B belinostat 0.4230525 0.8992814 0.42305 NA NA
BCORL1 gefitinib 0.4232724 0.8992814 0.42327 NA NA
MPL ponatinib 0.4233079 0.8992814 0.42331 NA NA
JAK2 belinostat 0.4239919 0.8994253 0.42399 NA NA
FBXW7 docetaxel 0.4241498 0.8994253 0.42415 NA NA
SRSF2 ruxolitinib 0.4243256 0.8994253 0.42433 NA NA
ASXL1 belinostat 0.4246638 0.8994253 0.42466 NA NA
PIGA cabozantinib 0.4249891 0.8994253 0.42499 NA NA
ABL1 dasatinib 0.4250747 0.8994253 0.42507 NA NA
ESR1 docetaxel 0.4254686 0.8996594 0.42547 NA NA
CBL vismodegib 0.4259523 0.8997855 0.42595 NA NA
CDK6 temozolomide 0.4260949 0.8997855 0.42609 NA NA
KMT2A nilotinib 0.4270492 0.9012015 0.42705 NA NA
AR gefitinib 0.4279563 0.9025160 0.42796 NA NA
PAX8 afatinib 0.4284981 0.9025462 0.42850 NA NA
ERBB2 erlotinib 0.4285389 0.9025462 0.42854 NA NA
SETD2 ponatinib 0.4289630 0.9028405 0.42896 NA NA
CD274 pazopanib 0.4298527 0.9033401 0.42985 NA NA
KMT2A erlotinib 0.4299866 0.9033401 0.42999 NA NA
KIT gefitinib 0.4300536 0.9033401 0.43005 NA NA
JAK1 pazopanib 0.4308861 0.9044755 0.43089 NA NA
BRCA1 ponatinib 0.4319743 0.9044755 0.43197 NA NA
PRPF8 tretinoin 0.4328990 0.9044755 0.43290 NA NA
SMC1A alectinib 0.4329711 0.9044755 0.43297 NA NA
NOTCH2 vismodegib 0.4329752 0.9044755 0.43298 NA NA
UGT1A1 dasatinib 0.4335809 0.9044755 0.43358 NA NA
PRPF8 imatinib 0.4337483 0.9044755 0.43375 NA NA
PDCD1 afatinib 0.4342385 0.9044755 0.43424 NA NA
PTPN11 nilotinib 0.4343504 0.9044755 0.43435 NA NA
BTK erlotinib 0.4357267 0.9044755 0.43573 NA NA
ZRSR2 alectinib 0.4359432 0.9044755 0.43594 NA NA
FLCN gefitinib 0.4366833 0.9044755 0.43668 NA NA
AR sunitinib 0.4370527 0.9044755 0.43705 NA NA
PDGFB temozolomide 0.4372281 0.9044755 0.43723 NA NA
NRAS nilotinib 0.4375929 0.9044755 0.43759 NA NA
CXCR4 bosutinib monohydrate 0.4378881 0.9044755 0.43789 NA NA
MPL dabrafenib 0.4381599 0.9044755 0.43816 NA NA
DNMT3A imatinib 0.4384088 0.9044755 0.43841 NA NA
CTCF midostaurin 0.4387679 0.9044755 0.43877 NA NA
SMC1A vismodegib 0.4388743 0.9044755 0.43887 NA NA
STAG2 dabrafenib 0.4388822 0.9044755 0.43888 NA NA
MYCN rucaparib 0.4390214 0.9044755 0.43902 NA NA
ASXL1 crizotinib 0.4390544 0.9044755 0.43905 NA NA
GNB1 palbociclib 0.4395108 0.9044755 0.43951 NA NA
NOTCH2 cabozantinib 0.4395724 0.9044755 0.43957 NA NA
FLT3 temozolomide 0.4398840 0.9044755 0.43988 NA NA
IDH2 lapatinib 0.4399819 0.9044755 0.43998 NA NA
CYP19A1 midostaurin 0.4400719 0.9044755 0.44007 NA NA
TP53 midostaurin 0.4402169 0.9044755 0.44022 NA NA
GATA3 dasatinib 0.4405211 0.9044755 0.44052 NA NA
XPO1 rucaparib 0.4406168 0.9044755 0.44062 NA NA
RAD21 dasatinib 0.4407374 0.9044755 0.44074 NA NA
SETD2 bosutinib monohydrate 0.4409242 0.9044755 0.44092 NA NA
ABL1 rucaparib 0.4411690 0.9044755 0.44117 NA NA
U2AF1 bosutinib monohydrate 0.4415049 0.9044755 0.44150 NA NA
ABL1 dabrafenib 0.4415642 0.9044755 0.44156 NA NA
IKZF1 gefitinib 0.4416698 0.9044755 0.44167 NA NA
KIT lapatinib 0.4421047 0.9044755 0.44210 NA NA
FLT3 pazopanib 0.4421181 0.9044755 0.44212 NA NA
NRAS vismodegib 0.4423058 0.9044755 0.44231 NA NA
IKZF1 dabrafenib 0.4423625 0.9044755 0.44236 NA NA
TSC2 pazopanib 0.4425985 0.9044755 0.44260 NA NA
ASXL1 dabrafenib 0.4430462 0.9044755 0.44305 NA NA
GNAS palbociclib 0.4431247 0.9044755 0.44312 NA NA
SSX1 tretinoin 0.4437195 0.9051079 0.44372 NA NA
NT5C2 docetaxel 0.4447563 0.9064968 0.44476 NA NA
CRLF2 belinostat 0.4451357 0.9064968 0.44514 NA NA
MYD88 nilotinib 0.4453090 0.9064968 0.44531 NA NA
ERBB2 alectinib 0.4455420 0.9064968 0.44554 NA NA
IDH1 palbociclib 0.4458469 0.9065179 0.44585 NA NA
GATA1 ruxolitinib 0.4461233 0.9065179 0.44612 NA NA
ERBB4 belinostat 0.4469217 0.9068658 0.44692 NA NA
GATA2 pazopanib 0.4469603 0.9068658 0.44696 NA NA
CTCF trametinib 0.4472654 0.9068658 0.44727 NA NA
GNA11 palbociclib 0.4475585 0.9068658 0.44756 NA NA
ZRSR2 temozolomide 0.4480301 0.9068658 0.44803 NA NA
ESR1 crizotinib 0.4487601 0.9068658 0.44876 NA NA
STAT3 crizotinib 0.4489323 0.9068658 0.44893 NA NA
AKT1 dabrafenib 0.4490980 0.9068658 0.44910 NA NA
STAG2 gefitinib 0.4492901 0.9068658 0.44929 NA NA
EGF ruxolitinib 0.4493943 0.9068658 0.44939 NA NA
BCOR ruxolitinib 0.4496662 0.9068658 0.44967 NA NA
PDGFRA dabrafenib 0.4498286 0.9068658 0.44983 NA NA
ATM vismodegib 0.4500064 0.9068658 0.45001 NA NA
SF1 ruxolitinib 0.4512242 0.9070551 0.45122 NA NA
RET afatinib 0.4515995 0.9070551 0.45160 NA NA
SF1 palbociclib 0.4523993 0.9070551 0.45240 NA NA
MAP2K2 pazopanib 0.4524699 0.9070551 0.45247 NA NA
GNA11 cabozantinib 0.4525437 0.9070551 0.45254 NA NA
G6PD tretinoin 0.4531080 0.9070551 0.45311 NA NA
CD79B ponatinib 0.4546022 0.9070551 0.45460 NA NA
CYP19A1 dasatinib 0.4547296 0.9070551 0.45473 NA NA
VHL tretinoin 0.4556069 0.9070551 0.45561 NA NA
PML bosutinib monohydrate 0.4556704 0.9070551 0.45567 NA NA
FGFR3 cabozantinib 0.4557661 0.9070551 0.45577 NA NA
ETV6 dabrafenib 0.4562090 0.9070551 0.45621 NA NA
CD274 nilotinib 0.4563967 0.9070551 0.45640 NA NA
KRAS vismodegib 0.4564329 0.9070551 0.45643 NA NA
MYCN ponatinib 0.4565739 0.9070551 0.45657 NA NA
CSF3R dasatinib 0.4567258 0.9070551 0.45673 NA NA
IDH1 imatinib 0.4567885 0.9070551 0.45679 NA NA
MYCN imatinib 0.4567885 0.9070551 0.45679 NA NA
HRAS trametinib 0.4570029 0.9070551 0.45700 NA NA
CDKN2A dabrafenib 0.4571153 0.9070551 0.45712 NA NA
PDGFB alectinib 0.4572960 0.9070551 0.45730 NA NA
DDIT3 ruxolitinib 0.4573678 0.9070551 0.45737 NA NA
SRSF2 docetaxel 0.4573914 0.9070551 0.45739 NA NA
MPL bosutinib monohydrate 0.4577383 0.9070551 0.45774 NA NA
MPL dasatinib 0.4578876 0.9070551 0.45789 NA NA
CYP19A1 erlotinib 0.4583847 0.9070551 0.45838 NA NA
BTK docetaxel 0.4588269 0.9070551 0.45883 NA NA
MYD88 temozolomide 0.4590388 0.9070551 0.45904 NA NA
NOTCH2 lapatinib 0.4590405 0.9070551 0.45904 NA NA
EGFR afatinib 0.4594260 0.9070551 0.45943 NA NA
DPYD bosutinib monohydrate 0.4594664 0.9070551 0.45947 NA NA
CSF3R palbociclib 0.4595627 0.9070551 0.45956 NA NA
KIT temozolomide 0.4596217 0.9070551 0.45962 NA NA
IKZF1 sunitinib 0.4601764 0.9070551 0.46018 NA NA
PAX8 gefitinib 0.4607206 0.9070551 0.46072 NA NA
PML imatinib 0.4608455 0.9070551 0.46085 NA NA
JAK2 nilotinib 0.4609294 0.9070551 0.46093 NA NA
IDH1 dasatinib 0.4613506 0.9070551 0.46135 NA NA
MYCN dasatinib 0.4613506 0.9070551 0.46135 NA NA
DNMT3A erlotinib 0.4620527 0.9070551 0.46205 NA NA
MET nilotinib 0.4620552 0.9070551 0.46206 NA NA
FGFR2 belinostat 0.4626400 0.9070551 0.46264 NA NA
U2AF1 crizotinib 0.4627036 0.9070551 0.46270 NA NA
XPO1 bosutinib monohydrate 0.4627645 0.9070551 0.46276 NA NA
CTNNB1 lapatinib 0.4631151 0.9070551 0.46312 NA NA
FGFR1 pazopanib 0.4634379 0.9070551 0.46344 NA NA
EML4 nilotinib 0.4635234 0.9070551 0.46352 NA NA
TET2 alectinib 0.4641646 0.9071261 0.46416 NA NA
SF3B1 dasatinib 0.4651305 0.9071261 0.46513 NA NA
FGFR1 belinostat 0.4651801 0.9071261 0.46518 NA NA
BRCA1 belinostat 0.4653768 0.9071261 0.46538 NA NA
XPO1 alectinib 0.4657556 0.9071261 0.46576 NA NA
JAK1 sunitinib 0.4658224 0.9071261 0.46582 NA NA
PAX8 ponatinib 0.4661236 0.9071261 0.46612 NA NA
TP53 erlotinib 0.4662703 0.9071261 0.46627 NA NA
BRAF erlotinib 0.4662981 0.9071261 0.46630 NA NA
PTCH1 sunitinib 0.4664159 0.9071261 0.46642 NA NA
MAP2K2 docetaxel 0.4671915 0.9080785 0.46719 NA NA
SETD2 pazopanib 0.4675792 0.9082761 0.46758 NA NA
ABL1 imatinib 0.4679914 0.9085212 0.46799 NA NA
TP53 dasatinib 0.4684244 0.9085467 0.46842 NA NA
BRCA2 ponatinib 0.4687534 0.9085467 0.46875 NA NA
PDGFRB imatinib 0.4699331 0.9085467 0.46993 NA NA
SMC1A rucaparib 0.4701617 0.9085467 0.47016 NA NA
PRPF40B rucaparib 0.4712034 0.9085467 0.47120 NA NA
CREBBP ruxolitinib 0.4719661 0.9085467 0.47197 NA NA
SMC3 sunitinib 0.4719892 0.9085467 0.47199 NA NA
IDH1 gefitinib 0.4721833 0.9085467 0.47218 NA NA
PTCH1 dasatinib 0.4723552 0.9085467 0.47236 NA NA
ERBB3 palbociclib 0.4724268 0.9085467 0.47243 NA NA
JAK3 bosutinib monohydrate 0.4728655 0.9085467 0.47287 NA NA
CDKN2A imatinib 0.4734754 0.9085467 0.47348 NA NA
SMC1A afatinib 0.4735125 0.9085467 0.47351 NA NA
MGMT trametinib 0.4735520 0.9085467 0.47355 NA NA
SMO crizotinib 0.4736088 0.9085467 0.47361 NA NA
GATA2 alectinib 0.4737183 0.9085467 0.47372 NA NA
CDK6 alectinib 0.4739041 0.9085467 0.47390 NA NA
CD79B docetaxel 0.4739139 0.9085467 0.47391 NA NA
TSC2 vismodegib 0.4749053 0.9085467 0.47491 NA NA
MPL sunitinib 0.4753748 0.9085467 0.47537 NA NA
SETD2 trametinib 0.4755931 0.9085467 0.47559 NA NA
PTCH1 trametinib 0.4756384 0.9085467 0.47564 NA NA
PDGFRB ruxolitinib 0.4765472 0.9085467 0.47655 NA NA
SF3B1 palbociclib 0.4773083 0.9085467 0.47731 NA NA
MYD88 tretinoin 0.4774785 0.9085467 0.47748 NA NA
CDC73 belinostat 0.4780499 0.9085467 0.47805 NA NA
PDGFRA vismodegib 0.4781819 0.9085467 0.47818 NA NA
FANCL ruxolitinib 0.4784767 0.9085467 0.47848 NA NA
BRCA1 ruxolitinib 0.4788739 0.9085467 0.47887 NA NA
BCOR bosutinib monohydrate 0.4792497 0.9085467 0.47925 NA NA
PRPF40B pazopanib 0.4793312 0.9085467 0.47933 NA NA
CTNNB1 palbociclib 0.4793518 0.9085467 0.47935 NA NA
CRLF2 crizotinib 0.4795458 0.9085467 0.47955 NA NA
G6PD belinostat 0.4798818 0.9085467 0.47988 NA NA
GATA2 lapatinib 0.4800955 0.9085467 0.48010 NA NA
CREBBP afatinib 0.4804225 0.9085467 0.48042 NA NA
PDCD1 sunitinib 0.4810096 0.9085467 0.48101 NA NA
CALR sunitinib 0.4811019 0.9085467 0.48110 NA NA
NT5C2 rucaparib 0.4816750 0.9085467 0.48168 NA NA
NPM1 ruxolitinib 0.4817234 0.9085467 0.48172 NA NA
PDGFB ponatinib 0.4821695 0.9085467 0.48217 NA NA
AR vismodegib 0.4823074 0.9085467 0.48231 NA NA
ETV6 rucaparib 0.4827390 0.9085467 0.48274 NA NA
JAK3 midostaurin 0.4827637 0.9085467 0.48276 NA NA
PRPF40B afatinib 0.4830174 0.9085467 0.48302 NA NA
PRPF40B gefitinib 0.4831030 0.9085467 0.48310 NA NA
HRAS vismodegib 0.4831149 0.9085467 0.48311 NA NA
G6PD pazopanib 0.4835225 0.9085467 0.48352 NA NA
BCOR dasatinib 0.4835917 0.9085467 0.48359 NA NA
GNAS dabrafenib 0.4837630 0.9085467 0.48376 NA NA
NOTCH1 erlotinib 0.4838940 0.9085467 0.48389 NA NA
ZRSR2 pazopanib 0.4840326 0.9085467 0.48403 NA NA
ERBB2 sunitinib 0.4842706 0.9085467 0.48427 NA NA
BCOR nilotinib 0.4843638 0.9085467 0.48436 NA NA
WHSC1 palbociclib 0.4845512 0.9085467 0.48455 NA NA
CYP19A1 docetaxel 0.4847190 0.9085467 0.48472 NA NA
ASXL1 pazopanib 0.4847323 0.9085467 0.48473 NA NA
CTCF afatinib 0.4847708 0.9085467 0.48477 NA NA
EGF pazopanib 0.4848824 0.9085467 0.48488 NA NA
AKT3 afatinib 0.4858445 0.9093988 0.48584 NA NA
CDC73 gefitinib 0.4859099 0.9093988 0.48591 NA NA
WT1 belinostat 0.4865711 0.9101000 0.48657 NA NA
GNAQ midostaurin 0.4871146 0.9103158 0.48711 NA NA
PDGFRB afatinib 0.4872986 0.9103158 0.48730 NA NA
CSF3R erlotinib 0.4879427 0.9103158 0.48794 NA NA
STAT3 gefitinib 0.4879455 0.9103158 0.48795 NA NA
PHF6 imatinib 0.4884193 0.9103158 0.48842 NA NA
KRAS erlotinib 0.4886809 0.9103158 0.48868 NA NA
CBLB vismodegib 0.4886928 0.9103158 0.48869 NA NA
GNAS crizotinib 0.4890065 0.9103662 0.48901 NA NA
KMT2A rucaparib 0.4911204 0.9124230 0.49112 NA NA
TSC2 erlotinib 0.4915604 0.9124230 0.49156 NA NA
UGT1A1 nilotinib 0.4918297 0.9124230 0.49183 NA NA
GATA2 tretinoin 0.4920281 0.9124230 0.49203 NA NA
KMT2A vismodegib 0.4929627 0.9124230 0.49296 NA NA
CBLB cabozantinib 0.4931138 0.9124230 0.49311 NA NA
RIT1 docetaxel 0.4934091 0.9124230 0.49341 NA NA
AR erlotinib 0.4934194 0.9124230 0.49342 NA NA
EZH2 pazopanib 0.4934659 0.9124230 0.49347 NA NA
IDH1 vismodegib 0.4935289 0.9124230 0.49353 NA NA
CYP19A1 lapatinib 0.4937490 0.9124230 0.49375 NA NA
JAK1 dabrafenib 0.4940334 0.9124230 0.49403 NA NA
SSX1 docetaxel 0.4946266 0.9124230 0.49463 NA NA
KMT2A docetaxel 0.4952628 0.9124230 0.49526 NA NA
IKZF1 ponatinib 0.4960463 0.9124230 0.49605 NA NA
PDGFB dabrafenib 0.4964153 0.9124230 0.49642 NA NA
PDCD1 imatinib 0.4965076 0.9124230 0.49651 NA NA
KMT2A bosutinib monohydrate 0.4965364 0.9124230 0.49654 NA NA
RET tretinoin 0.4969056 0.9124230 0.49691 NA NA
JAK3 palbociclib 0.4969978 0.9124230 0.49700 NA NA
AR nilotinib 0.4970145 0.9124230 0.49701 NA NA
ALK midostaurin 0.4971993 0.9124230 0.49720 NA NA
U2AF1 afatinib 0.4972408 0.9124230 0.49724 NA NA
CSF3R docetaxel 0.4974614 0.9124230 0.49746 NA NA
PHF6 erlotinib 0.4975229 0.9124230 0.49752 NA NA
CXCR4 rucaparib 0.4978429 0.9124230 0.49784 NA NA
MAP2K1 erlotinib 0.4978681 0.9124230 0.49787 NA NA
MYD88 cabozantinib 0.4985291 0.9124284 0.49853 NA NA
PDGFRA sunitinib 0.4989956 0.9124284 0.49900 NA NA
RET cabozantinib 0.4991041 0.9124284 0.49910 NA NA
DDIT3 dabrafenib 0.4991662 0.9124284 0.49917 NA NA
EGFR nilotinib 0.4993412 0.9124284 0.49934 NA NA
PTEN trametinib 0.4995948 0.9124284 0.49959 NA NA
PIK3CA palbociclib 0.5003636 0.9133073 0.50036 NA NA
CDK6 dasatinib 0.5013750 0.9141140 0.50137 NA NA
WHSC1 sunitinib 0.5013812 0.9141140 0.50138 NA NA
FBXW7 pazopanib 0.5019388 0.9142288 0.50194 NA NA
STAT3 belinostat 0.5022511 0.9142288 0.50225 NA NA
NT5C2 temozolomide 0.5024237 0.9142288 0.50242 NA NA
ERBB3 lapatinib 0.5028840 0.9142288 0.50288 NA NA
FANCL cabozantinib 0.5034590 0.9142288 0.50346 NA NA
RET crizotinib 0.5041789 0.9142288 0.50418 NA NA
KMT2A ruxolitinib 0.5043906 0.9142288 0.50439 NA NA
G6PD imatinib 0.5046668 0.9142288 0.50467 NA NA
CEBPA cabozantinib 0.5051263 0.9142288 0.50513 NA NA
NOTCH2 bosutinib monohydrate 0.5054644 0.9142288 0.50546 NA NA
PHF6 sunitinib 0.5059450 0.9142288 0.50594 NA NA
DDIT3 midostaurin 0.5062536 0.9142288 0.50625 NA NA
RAD21 gefitinib 0.5067814 0.9142288 0.50678 NA NA
NOTCH2 midostaurin 0.5068663 0.9142288 0.50687 NA NA
GATA1 lapatinib 0.5069297 0.9142288 0.50693 NA NA
ATM dasatinib 0.5070758 0.9142288 0.50708 NA NA
DDIT3 cabozantinib 0.5071215 0.9142288 0.50712 NA NA
CYP19A1 afatinib 0.5081199 0.9142288 0.50812 NA NA
SSX1 midostaurin 0.5081623 0.9142288 0.50816 NA NA
PAX5 gefitinib 0.5085301 0.9142288 0.50853 NA NA
DPYD midostaurin 0.5086465 0.9142288 0.50865 NA NA
ERBB3 pazopanib 0.5092517 0.9142288 0.50925 NA NA
CTCF tretinoin 0.5098762 0.9142288 0.50988 NA NA
TET2 imatinib 0.5098787 0.9142288 0.50988 NA NA
CDK4 pazopanib 0.5102304 0.9142288 0.51023 NA NA
HRAS ponatinib 0.5102704 0.9142288 0.51027 NA NA
MYCN temozolomide 0.5105673 0.9142288 0.51057 NA NA
PDGFRB sunitinib 0.5106193 0.9142288 0.51062 NA NA
STAG2 erlotinib 0.5108704 0.9142288 0.51087 NA NA
BRAF gefitinib 0.5109860 0.9142288 0.51099 NA NA
ASXL1 docetaxel 0.5112416 0.9142288 0.51124 NA NA
GATA1 trametinib 0.5114237 0.9142288 0.51142 NA NA
PML vismodegib 0.5118312 0.9142288 0.51183 NA NA
FANCL trametinib 0.5123217 0.9142288 0.51232 NA NA
CBL ruxolitinib 0.5128995 0.9142288 0.51290 NA NA
SETD2 dasatinib 0.5131984 0.9142288 0.51320 NA NA
KIT palbociclib 0.5134101 0.9142288 0.51341 NA NA
CDK6 nilotinib 0.5134963 0.9142288 0.51350 NA NA
ESR1 dabrafenib 0.5138002 0.9142288 0.51380 NA NA
PIK3CA tretinoin 0.5140711 0.9142288 0.51407 NA NA
EGF temozolomide 0.5143110 0.9142288 0.51431 NA NA
PDGFRB temozolomide 0.5143244 0.9142288 0.51432 NA NA
SF1 sunitinib 0.5144054 0.9142288 0.51441 NA NA
EML4 palbociclib 0.5149978 0.9142288 0.51500 NA NA
FLT3 dabrafenib 0.5153597 0.9142288 0.51536 NA NA
JAK3 sunitinib 0.5153903 0.9142288 0.51539 NA NA
CDKN2A belinostat 0.5154714 0.9142288 0.51547 NA NA
SMC3 erlotinib 0.5156776 0.9142288 0.51568 NA NA
MYD88 dasatinib 0.5156798 0.9142288 0.51568 NA NA
SMC1A pazopanib 0.5163177 0.9142288 0.51632 NA NA
DPYD ruxolitinib 0.5165164 0.9142288 0.51652 NA NA
CYP19A1 sunitinib 0.5166344 0.9142288 0.51663 NA NA
EZH2 dasatinib 0.5167556 0.9142288 0.51676 NA NA
MPL belinostat 0.5173049 0.9142288 0.51730 NA NA
IL7R nilotinib 0.5173148 0.9142288 0.51731 NA NA
DPYD docetaxel 0.5183010 0.9142288 0.51830 NA NA
CD79B palbociclib 0.5185060 0.9142288 0.51851 NA NA
DDIT3 rucaparib 0.5186394 0.9142288 0.51864 NA NA
FGFR1 crizotinib 0.5187132 0.9142288 0.51871 NA NA
GNA11 ruxolitinib 0.5187155 0.9142288 0.51872 NA NA
PAX8 dabrafenib 0.5195687 0.9145772 0.51957 NA NA
MET docetaxel 0.5196512 0.9145772 0.51965 NA NA
PTPN11 temozolomide 0.5198840 0.9145772 0.51988 NA NA
DPYD imatinib 0.5204070 0.9145772 0.52041 NA NA
EGFR imatinib 0.5206143 0.9145772 0.52061 NA NA
DPYD gefitinib 0.5210093 0.9145772 0.52101 NA NA
GNAQ pazopanib 0.5212039 0.9145772 0.52120 NA NA
PRPF8 cabozantinib 0.5214349 0.9145772 0.52143 NA NA
DNMT3A palbociclib 0.5222786 0.9145772 0.52228 NA NA
CBLB midostaurin 0.5224343 0.9145772 0.52243 NA NA
FANCL lapatinib 0.5224774 0.9145772 0.52248 NA NA
DPYD alectinib 0.5225472 0.9145772 0.52255 NA NA
NPM1 gefitinib 0.5227495 0.9145772 0.52275 NA NA
CDK4 trametinib 0.5235152 0.9145772 0.52352 NA NA
CREBBP tretinoin 0.5236971 0.9145772 0.52370 NA NA
SF1 crizotinib 0.5238314 0.9145772 0.52383 NA NA
RPL10 dabrafenib 0.5241142 0.9145772 0.52411 NA NA
KMT2A trametinib 0.5242068 0.9145772 0.52421 NA NA
ASXL1 palbociclib 0.5246346 0.9145772 0.52463 NA NA
FGFR3 rucaparib 0.5246724 0.9145772 0.52467 NA NA
CTCF vismodegib 0.5249865 0.9146226 0.52499 NA NA
MDM2 gefitinib 0.5257801 0.9150605 0.52578 NA NA
AKT3 crizotinib 0.5260488 0.9150605 0.52605 NA NA
CSF3R cabozantinib 0.5261751 0.9150605 0.52618 NA NA
NRAS midostaurin 0.5263903 0.9150605 0.52639 NA NA
GATA2 belinostat 0.5271314 0.9158476 0.52713 NA NA
JAK3 lapatinib 0.5279853 0.9163898 0.52799 NA NA
PDGFB trametinib 0.5280206 0.9163898 0.52802 NA NA
NT5C2 vismodegib 0.5285543 0.9168151 0.52855 NA NA
SMC3 bosutinib monohydrate 0.5290075 0.9169691 0.52901 NA NA
BRAF sunitinib 0.5308225 0.9169691 0.53082 NA NA
MYD88 midostaurin 0.5310291 0.9169691 0.53103 NA NA
WT1 pazopanib 0.5310459 0.9169691 0.53105 NA NA
RUNX1 palbociclib 0.5310874 0.9169691 0.53109 NA NA
TET2 afatinib 0.5315227 0.9169691 0.53152 NA NA
ABL1 crizotinib 0.5320626 0.9169691 0.53206 NA NA
CBL imatinib 0.5322515 0.9169691 0.53225 NA NA
CXCR4 temozolomide 0.5324701 0.9169691 0.53247 NA NA
DNMT3A midostaurin 0.5328652 0.9169691 0.53287 NA NA
PHF6 ponatinib 0.5333653 0.9169691 0.53337 NA NA
CTCF bosutinib monohydrate 0.5335475 0.9169691 0.53355 NA NA
PHF6 alectinib 0.5336040 0.9169691 0.53360 NA NA
SMO midostaurin 0.5343564 0.9169691 0.53436 NA NA
JAK3 cabozantinib 0.5344359 0.9169691 0.53444 NA NA
G6PD erlotinib 0.5348254 0.9169691 0.53483 NA NA
AR alectinib 0.5352746 0.9169691 0.53527 NA NA
CBL docetaxel 0.5357729 0.9169691 0.53577 NA NA
CDK4 dasatinib 0.5363244 0.9169691 0.53632 NA NA
JAK3 erlotinib 0.5363347 0.9169691 0.53633 NA NA
ERBB3 nilotinib 0.5371710 0.9169691 0.53717 NA NA
ETV6 ruxolitinib 0.5373343 0.9169691 0.53733 NA NA
SSX1 ponatinib 0.5376169 0.9169691 0.53762 NA NA
CXCR4 palbociclib 0.5381348 0.9169691 0.53813 NA NA
RAD21 ponatinib 0.5382645 0.9169691 0.53826 NA NA
SF1 gefitinib 0.5385821 0.9169691 0.53858 NA NA
MAP2K2 nilotinib 0.5386936 0.9169691 0.53869 NA NA
ETV6 alectinib 0.5387069 0.9169691 0.53871 NA NA
RUNX1 dabrafenib 0.5389208 0.9169691 0.53892 NA NA
MYCN trametinib 0.5389272 0.9169691 0.53893 NA NA
TSC2 imatinib 0.5394738 0.9169691 0.53947 NA NA
FGFR2 nilotinib 0.5398280 0.9169691 0.53983 NA NA
BCORL1 crizotinib 0.5399529 0.9169691 0.53995 NA NA
GNA11 afatinib 0.5399949 0.9169691 0.53999 NA NA
CEBPA rucaparib 0.5399967 0.9169691 0.54000 NA NA
ABL1 midostaurin 0.5402282 0.9169691 0.54023 NA NA
MPL alectinib 0.5402344 0.9169691 0.54023 NA NA
STAT3 midostaurin 0.5403698 0.9169691 0.54037 NA NA
CTLA4 gefitinib 0.5404583 0.9169691 0.54046 NA NA
WT1 vismodegib 0.5404655 0.9169691 0.54047 NA NA
PTCH1 dabrafenib 0.5410696 0.9169691 0.54107 NA NA
ETV6 ponatinib 0.5414576 0.9169691 0.54146 NA NA
BRCA2 temozolomide 0.5416844 0.9169691 0.54168 NA NA
CXCR4 midostaurin 0.5422466 0.9169691 0.54225 NA NA
PIGA nilotinib 0.5423423 0.9169691 0.54234 NA NA
SMO ponatinib 0.5427786 0.9169691 0.54278 NA NA
WT1 temozolomide 0.5429937 0.9169691 0.54299 NA NA
PIGA palbociclib 0.5433316 0.9169691 0.54333 NA NA
TSC2 midostaurin 0.5433441 0.9169691 0.54334 NA NA
TET2 docetaxel 0.5434908 0.9169691 0.54349 NA NA
FBXW7 rucaparib 0.5434920 0.9169691 0.54349 NA NA
JAK3 temozolomide 0.5436890 0.9169691 0.54369 NA NA
SETBP1 docetaxel 0.5442333 0.9169691 0.54423 NA NA
CBL midostaurin 0.5442339 0.9169691 0.54423 NA NA
SF1 temozolomide 0.5448516 0.9175231 0.54485 NA NA
FLCN midostaurin 0.5460539 0.9190606 0.54605 NA NA
AKT1 cabozantinib 0.5467795 0.9196205 0.54678 NA NA
GNAS lapatinib 0.5469657 0.9196205 0.54697 NA NA
UGT1A1 dabrafenib 0.5474325 0.9199087 0.54743 NA NA
PDGFB midostaurin 0.5477164 0.9199087 0.54772 NA NA
WT1 docetaxel 0.5485785 0.9204284 0.54858 NA NA
BTK rucaparib 0.5488597 0.9204284 0.54886 NA NA
GNB1 gefitinib 0.5488952 0.9204284 0.54890 NA NA
UGT1A1 temozolomide 0.5500430 0.9206369 0.55004 NA NA
MGMT crizotinib 0.5501355 0.9206369 0.55014 NA NA
CDK6 tretinoin 0.5504161 0.9206369 0.55042 NA NA
RET bosutinib monohydrate 0.5509591 0.9206369 0.55096 NA NA
ROS1 gefitinib 0.5511895 0.9206369 0.55119 NA NA
GNAS pazopanib 0.5517444 0.9206369 0.55174 NA NA
PAX5 alectinib 0.5518586 0.9206369 0.55186 NA NA
CD79B belinostat 0.5522460 0.9206369 0.55225 NA NA
KIT midostaurin 0.5523909 0.9206369 0.55239 NA NA
CYP19A1 pazopanib 0.5523979 0.9206369 0.55240 NA NA
CD274 afatinib 0.5528302 0.9206369 0.55283 NA NA
IDH1 ruxolitinib 0.5528888 0.9206369 0.55289 NA NA
ERBB3 alectinib 0.5530430 0.9206369 0.55304 NA NA
STAT3 cabozantinib 0.5530778 0.9206369 0.55308 NA NA
MGMT ponatinib 0.5540759 0.9207127 0.55408 NA NA
AKT1 belinostat 0.5547454 0.9207127 0.55475 NA NA
ATM alectinib 0.5548611 0.9207127 0.55486 NA NA
CYP19A1 tretinoin 0.5549899 0.9207127 0.55499 NA NA
MYCN gefitinib 0.5550598 0.9207127 0.55506 NA NA
ZRSR2 belinostat 0.5551241 0.9207127 0.55512 NA NA
MPL palbociclib 0.5554405 0.9207127 0.55544 NA NA
AKT2 midostaurin 0.5554426 0.9207127 0.55544 NA NA
RUNX1 belinostat 0.5560288 0.9212037 0.55603 NA NA
GATA3 cabozantinib 0.5564051 0.9213465 0.55641 NA NA
TSC2 dasatinib 0.5568736 0.9216417 0.55687 NA NA
MYD88 erlotinib 0.5580136 0.9226946 0.55801 NA NA
ALK pazopanib 0.5581192 0.9226946 0.55812 NA NA
GATA1 vismodegib 0.5583929 0.9226946 0.55839 NA NA
CD79B gefitinib 0.5587538 0.9226946 0.55875 NA NA
PAX8 belinostat 0.5590195 0.9226946 0.55902 NA NA
PTPN11 afatinib 0.5596334 0.9226946 0.55963 NA NA
RET ruxolitinib 0.5597886 0.9226946 0.55979 NA NA
IKZF1 bosutinib monohydrate 0.5599796 0.9226946 0.55998 NA NA
CEBPA gefitinib 0.5601244 0.9226946 0.56012 NA NA
MAP2K2 alectinib 0.5608883 0.9234739 0.56089 NA NA
ERBB3 afatinib 0.5614904 0.9239863 0.56149 NA NA
JAK2 crizotinib 0.5623793 0.9240874 0.56238 NA NA
PML pazopanib 0.5629739 0.9240874 0.56297 NA NA
BCOR erlotinib 0.5633547 0.9240874 0.56335 NA NA
TSC1 erlotinib 0.5633547 0.9240874 0.56335 NA NA
EGF erlotinib 0.5636517 0.9240874 0.56365 NA NA
PIGA dasatinib 0.5637000 0.9240874 0.56370 NA NA
ESR1 sunitinib 0.5643768 0.9240874 0.56438 NA NA
G6PD rucaparib 0.5646292 0.9240874 0.56463 NA NA
MDM2 ruxolitinib 0.5647650 0.9240874 0.56476 NA NA
PAX8 palbociclib 0.5648846 0.9240874 0.56488 NA NA
RET gefitinib 0.5658382 0.9240874 0.56584 NA NA
FLT3 sunitinib 0.5660424 0.9240874 0.56604 NA NA
PDGFB sunitinib 0.5660424 0.9240874 0.56604 NA NA
CBLB dabrafenib 0.5660789 0.9240874 0.56608 NA NA
NCOA2 midostaurin 0.5663758 0.9240874 0.56638 NA NA
EGFR temozolomide 0.5669345 0.9240874 0.56693 NA NA
CD79B bosutinib monohydrate 0.5670616 0.9240874 0.56706 NA NA
JAK2 palbociclib 0.5675682 0.9240874 0.56757 NA NA
TET2 crizotinib 0.5676235 0.9240874 0.56762 NA NA
BTK ruxolitinib 0.5677799 0.9240874 0.56778 NA NA
FLT3 lapatinib 0.5679419 0.9240874 0.56794 NA NA
CYP19A1 gefitinib 0.5683932 0.9240874 0.56839 NA NA
FGFR3 palbociclib 0.5685115 0.9240874 0.56851 NA NA
PAX8 crizotinib 0.5685501 0.9240874 0.56855 NA NA
AR imatinib 0.5689905 0.9240874 0.56899 NA NA
CSF3R vismodegib 0.5693374 0.9240874 0.56934 NA NA
AKT3 imatinib 0.5699859 0.9240874 0.56999 NA NA
CDK6 imatinib 0.5699859 0.9240874 0.56999 NA NA
CD274 trametinib 0.5701244 0.9240874 0.57012 NA NA
JAK2 erlotinib 0.5702807 0.9240874 0.57028 NA NA
SMC3 afatinib 0.5706429 0.9242029 0.57064 NA NA
TSC2 cabozantinib 0.5710996 0.9244710 0.57110 NA NA
CDC73 ruxolitinib 0.5718819 0.9249377 0.57188 NA NA
SF1 tretinoin 0.5723561 0.9249377 0.57236 NA NA
BTK vismodegib 0.5724794 0.9249377 0.57248 NA NA
TSC1 docetaxel 0.5725527 0.9249377 0.57255 NA NA
IL7R crizotinib 0.5731295 0.9253987 0.57313 NA NA
FGFR1 imatinib 0.5744946 0.9267696 0.57449 NA NA
WT1 crizotinib 0.5747532 0.9267696 0.57475 NA NA
NRAS sunitinib 0.5749041 0.9267696 0.57490 NA NA
STAT3 imatinib 0.5754057 0.9267696 0.57541 NA NA
U2AF1 alectinib 0.5756944 0.9267696 0.57569 NA NA
CTNNB1 ponatinib 0.5759382 0.9267696 0.57594 NA NA
JAK3 ponatinib 0.5765409 0.9267696 0.57654 NA NA
PRPF8 vismodegib 0.5766264 0.9267696 0.57663 NA NA
AKT3 bosutinib monohydrate 0.5766764 0.9267696 0.57668 NA NA
BRCA1 rucaparib 0.5768966 0.9267696 0.57690 NA NA
STAG2 tretinoin 0.5772249 0.9267965 0.57722 NA NA
CDC73 palbociclib 0.5776497 0.9267965 0.57765 NA NA
GNB1 afatinib 0.5781400 0.9267965 0.57814 NA NA
AKT3 palbociclib 0.5783610 0.9267965 0.57836 NA NA
CBLB temozolomide 0.5787407 0.9267965 0.57874 NA NA
MGMT belinostat 0.5789471 0.9267965 0.57895 NA NA
GNA11 alectinib 0.5790606 0.9267965 0.57906 NA NA
KMT2A crizotinib 0.5794379 0.9267965 0.57944 NA NA
ALK cabozantinib 0.5795396 0.9267965 0.57954 NA NA
ABL1 sunitinib 0.5802023 0.9273892 0.58020 NA NA
DNAJB1 alectinib 0.5806618 0.9273928 0.58066 NA NA
CDK6 lapatinib 0.5808070 0.9273928 0.58081 NA NA
ROS1 midostaurin 0.5814725 0.9273928 0.58147 NA NA
CD79B afatinib 0.5816393 0.9273928 0.58164 NA NA
ALK rucaparib 0.5819295 0.9273928 0.58193 NA NA
PRPF40B dasatinib 0.5822601 0.9273928 0.58226 NA NA
TSC2 ruxolitinib 0.5824296 0.9273928 0.58243 NA NA
CREBBP dabrafenib 0.5825405 0.9273928 0.58254 NA NA
PDGFRA docetaxel 0.5828922 0.9274878 0.58289 NA NA
PTCH1 ruxolitinib 0.5835921 0.9276687 0.58359 NA NA
RET ponatinib 0.5838741 0.9276687 0.58387 NA NA
RET nilotinib 0.5840052 0.9276687 0.58401 NA NA
VHL dabrafenib 0.5845704 0.9276687 0.58457 NA NA
GNA11 belinostat 0.5851873 0.9276687 0.58519 NA NA
TSC2 rucaparib 0.5851976 0.9276687 0.58520 NA NA
NPM1 ponatinib 0.5854791 0.9276687 0.58548 NA NA
GNA11 tretinoin 0.5858785 0.9276687 0.58588 NA NA
BRCA1 afatinib 0.5859699 0.9276687 0.58597 NA NA
EGFR ponatinib 0.5861711 0.9276687 0.58617 NA NA
STAT3 afatinib 0.5862188 0.9276687 0.58622 NA NA
CDK6 palbociclib 0.5875801 0.9283988 0.58758 NA NA
NOTCH2 belinostat 0.5876845 0.9283988 0.58768 NA NA
DNAJB1 palbociclib 0.5878256 0.9283988 0.58783 NA NA
TET2 dasatinib 0.5882617 0.9283988 0.58826 NA NA
PDGFRA temozolomide 0.5883211 0.9283988 0.58832 NA NA
CRLF2 dasatinib 0.5887259 0.9283988 0.58873 NA NA
PIK3CA crizotinib 0.5887265 0.9283988 0.58873 NA NA
CDK4 midostaurin 0.5892242 0.9286134 0.58922 NA NA
CDC73 pazopanib 0.5896955 0.9286134 0.58970 NA NA
FLCN belinostat 0.5905635 0.9286134 0.59056 NA NA
KMT2A dasatinib 0.5908858 0.9286134 0.59089 NA NA
CDK4 cabozantinib 0.5910559 0.9286134 0.59106 NA NA
PTEN temozolomide 0.5920742 0.9286134 0.59207 NA NA
GATA2 crizotinib 0.5930452 0.9286134 0.59305 NA NA
FGFR1 dasatinib 0.5933885 0.9286134 0.59339 NA NA
FBXW7 vismodegib 0.5934236 0.9286134 0.59342 NA NA
MAP2K1 dabrafenib 0.5935300 0.9286134 0.59353 NA NA
FGFR3 sunitinib 0.5938828 0.9286134 0.59388 NA NA
EGFR tretinoin 0.5940328 0.9286134 0.59403 NA NA
HRAS pazopanib 0.5941431 0.9286134 0.59414 NA NA
XPO1 pazopanib 0.5942691 0.9286134 0.59427 NA NA
STAT3 rucaparib 0.5946002 0.9286134 0.59460 NA NA
DNAJB1 afatinib 0.5947756 0.9286134 0.59478 NA NA
MYCN midostaurin 0.5948521 0.9286134 0.59485 NA NA
KIT pazopanib 0.5948891 0.9286134 0.59489 NA NA
PML rucaparib 0.5950165 0.9286134 0.59502 NA NA
EGFR lapatinib 0.5960871 0.9286134 0.59609 NA NA
NT5C2 gefitinib 0.5963461 0.9286134 0.59635 NA NA
WHSC1 belinostat 0.5965935 0.9286134 0.59659 NA NA
PTEN gefitinib 0.5969493 0.9286134 0.59695 NA NA
CDK6 vismodegib 0.5972260 0.9286134 0.59723 NA NA
ESR1 ruxolitinib 0.5973766 0.9286134 0.59738 NA NA
MGMT nilotinib 0.5978288 0.9286134 0.59783 NA NA
MYD88 vismodegib 0.5979041 0.9286134 0.59790 NA NA
PRPF40B sunitinib 0.5980324 0.9286134 0.59803 NA NA
CXCR4 dasatinib 0.5982362 0.9286134 0.59824 NA NA
SMC1A nilotinib 0.5984846 0.9286134 0.59848 NA NA
ABL1 erlotinib 0.5985108 0.9286134 0.59851 NA NA
NOTCH1 palbociclib 0.5985739 0.9286134 0.59857 NA NA
HRAS ruxolitinib 0.5989160 0.9286134 0.59892 NA NA
NOTCH1 alectinib 0.5992984 0.9286134 0.59930 NA NA
GATA3 midostaurin 0.5993247 0.9286134 0.59932 NA NA
IKZF1 alectinib 0.5993884 0.9286134 0.59939 NA NA
CEBPA nilotinib 0.6007708 0.9299466 0.60077 NA NA
IDH2 sunitinib 0.6010327 0.9299466 0.60103 NA NA
WT1 imatinib 0.6012342 0.9299466 0.60123 NA NA
VHL sunitinib 0.6024171 0.9299466 0.60242 NA NA
CBLB belinostat 0.6024277 0.9299466 0.60243 NA NA
CYP19A1 cabozantinib 0.6024929 0.9299466 0.60249 NA NA
BRAF crizotinib 0.6026642 0.9299466 0.60266 NA NA
AKT2 bosutinib monohydrate 0.6027318 0.9299466 0.60273 NA NA
CTNNB1 sunitinib 0.6030844 0.9299466 0.60308 NA NA
CBL palbociclib 0.6031882 0.9299466 0.60319 NA NA
SETD2 sunitinib 0.6036916 0.9299466 0.60369 NA NA
STAT3 temozolomide 0.6037625 0.9299466 0.60376 NA NA
SMC3 nilotinib 0.6046846 0.9301376 0.60468 NA NA
TPMT trametinib 0.6050220 0.9301376 0.60502 NA NA
SMO rucaparib 0.6056010 0.9301376 0.60560 NA NA
ROS1 sunitinib 0.6060667 0.9301376 0.60607 NA NA
ATM trametinib 0.6061888 0.9301376 0.60619 NA NA
GNA11 trametinib 0.6063817 0.9301376 0.60638 NA NA
XPO1 palbociclib 0.6065594 0.9301376 0.60656 NA NA
GATA2 docetaxel 0.6066753 0.9301376 0.60668 NA NA
GATA3 ruxolitinib 0.6067286 0.9301376 0.60673 NA NA
EED trametinib 0.6074766 0.9301376 0.60748 NA NA
CSF3R sunitinib 0.6077091 0.9301376 0.60771 NA NA
FGFR1 rucaparib 0.6079969 0.9301376 0.60800 NA NA
U2AF1 tretinoin 0.6080591 0.9301376 0.60806 NA NA
NRAS dasatinib 0.6085294 0.9301376 0.60853 NA NA
AKT3 ruxolitinib 0.6086854 0.9301376 0.60869 NA NA
SH2B3 ruxolitinib 0.6086854 0.9301376 0.60869 NA NA
EGF alectinib 0.6088652 0.9301376 0.60887 NA NA
DNAJB1 tretinoin 0.6098927 0.9305135 0.60989 NA NA
ERBB4 vismodegib 0.6099615 0.9305135 0.60996 NA NA
MDM2 lapatinib 0.6102843 0.9305135 0.61028 NA NA
CDK4 temozolomide 0.6106364 0.9305135 0.61064 NA NA
CDK4 afatinib 0.6107092 0.9305135 0.61071 NA NA
BCOR sunitinib 0.6110543 0.9305135 0.61105 NA NA
SETBP1 bosutinib monohydrate 0.6114437 0.9305135 0.61144 NA NA
BRCA2 docetaxel 0.6116514 0.9305135 0.61165 NA NA
SRSF2 belinostat 0.6119949 0.9305135 0.61199 NA NA
NT5C2 midostaurin 0.6123593 0.9305135 0.61236 NA NA
TSC1 ponatinib 0.6125905 0.9305135 0.61259 NA NA
CALR crizotinib 0.6126271 0.9305135 0.61263 NA NA
TP53 lapatinib 0.6134430 0.9312519 0.61344 NA NA
CSF3R pazopanib 0.6141144 0.9312519 0.61411 NA NA
ETV6 crizotinib 0.6144403 0.9312519 0.61444 NA NA
PRPF8 belinostat 0.6148581 0.9312519 0.61486 NA NA
FGFR2 lapatinib 0.6157059 0.9312519 0.61571 NA NA
GNAS ruxolitinib 0.6157098 0.9312519 0.61571 NA NA
MET ponatinib 0.6159349 0.9312519 0.61593 NA NA
GATA2 gefitinib 0.6160722 0.9312519 0.61607 NA NA
NOTCH1 sunitinib 0.6162376 0.9312519 0.61624 NA NA
GATA2 vismodegib 0.6168478 0.9312519 0.61685 NA NA
DDIT3 gefitinib 0.6170733 0.9312519 0.61707 NA NA
AKT2 sunitinib 0.6176121 0.9312519 0.61761 NA NA
VHL pazopanib 0.6176221 0.9312519 0.61762 NA NA
PML ponatinib 0.6178115 0.9312519 0.61781 NA NA
EML4 docetaxel 0.6185171 0.9312519 0.61852 NA NA
AKT1 pazopanib 0.6189835 0.9312519 0.61898 NA NA
CYP19A1 crizotinib 0.6190452 0.9312519 0.61905 NA NA
FLCN trametinib 0.6190484 0.9312519 0.61905 NA NA
CD79B cabozantinib 0.6190926 0.9312519 0.61909 NA NA
MYCN cabozantinib 0.6193520 0.9312519 0.61935 NA NA
JAK2 afatinib 0.6195384 0.9312519 0.61954 NA NA
SF1 ponatinib 0.6198294 0.9312519 0.61983 NA NA
PDCD1 vismodegib 0.6201762 0.9312519 0.62018 NA NA
ETV6 gefitinib 0.6204801 0.9312519 0.62048 NA NA
FGFR2 alectinib 0.6211625 0.9312519 0.62116 NA NA
G6PD sunitinib 0.6213525 0.9312519 0.62135 NA NA
PIGA sunitinib 0.6213525 0.9312519 0.62135 NA NA
FBXW7 alectinib 0.6219058 0.9312519 0.62191 NA NA
EED cabozantinib 0.6219404 0.9312519 0.62194 NA NA
NOTCH1 ruxolitinib 0.6220714 0.9312519 0.62207 NA NA
MGMT bosutinib monohydrate 0.6222029 0.9312519 0.62220 NA NA
DDIT3 tretinoin 0.6226906 0.9315427 0.62269 NA NA
CSF3R ruxolitinib 0.6235370 0.9319572 0.62354 NA NA
KRAS gefitinib 0.6235545 0.9319572 0.62355 NA NA
DNMT3A tretinoin 0.6240726 0.9319839 0.62407 NA NA
MPL vismodegib 0.6241592 0.9319839 0.62416 NA NA
ZRSR2 ponatinib 0.6253285 0.9332911 0.62533 NA NA
SMC3 gefitinib 0.6263365 0.9337683 0.62634 NA NA
PDGFB belinostat 0.6267736 0.9337683 0.62677 NA NA
SRSF2 dabrafenib 0.6268440 0.9337683 0.62684 NA NA
ZRSR2 lapatinib 0.6268747 0.9337683 0.62687 NA NA
MYD88 pazopanib 0.6271722 0.9337683 0.62717 NA NA
IDH1 midostaurin 0.6274123 0.9337683 0.62741 NA NA
ROS1 afatinib 0.6282804 0.9346222 0.62828 NA NA
PTEN erlotinib 0.6294097 0.9355064 0.62941 NA NA
SF3B1 pazopanib 0.6294639 0.9355064 0.62946 NA NA
EGF tretinoin 0.6298346 0.9356196 0.62983 NA NA
SETD2 rucaparib 0.6306943 0.9362277 0.63069 NA NA
MDM2 nilotinib 0.6317840 0.9362277 0.63178 NA NA
PIK3CA temozolomide 0.6319837 0.9362277 0.63198 NA NA
TPMT afatinib 0.6320485 0.9362277 0.63205 NA NA
ETV6 lapatinib 0.6320960 0.9362277 0.63210 NA NA
IDH1 tretinoin 0.6327016 0.9362277 0.63270 NA NA
FBXW7 nilotinib 0.6329663 0.9362277 0.63297 NA NA
SMO erlotinib 0.6333592 0.9362277 0.63336 NA NA
PIGA ruxolitinib 0.6341800 0.9362277 0.63418 NA NA
RIT1 cabozantinib 0.6344014 0.9362277 0.63440 NA NA
SETD2 afatinib 0.6344824 0.9362277 0.63448 NA NA
BCOR tretinoin 0.6346058 0.9362277 0.63461 NA NA
AKT1 trametinib 0.6346674 0.9362277 0.63467 NA NA
PAX5 tretinoin 0.6346748 0.9362277 0.63467 NA NA
EGFR sunitinib 0.6347395 0.9362277 0.63474 NA NA
ASXL1 rucaparib 0.6357840 0.9362277 0.63578 NA NA
CEBPA belinostat 0.6359932 0.9362277 0.63599 NA NA
PML erlotinib 0.6360548 0.9362277 0.63605 NA NA
SF3B1 imatinib 0.6360653 0.9362277 0.63607 NA NA
GATA2 afatinib 0.6361396 0.9362277 0.63614 NA NA
CREBBP imatinib 0.6365514 0.9363999 0.63655 NA NA
FANCL gefitinib 0.6370118 0.9366432 0.63701 NA NA
PDGFRB alectinib 0.6381495 0.9378819 0.63815 NA NA
PRPF40B crizotinib 0.6384729 0.9379232 0.63847 NA NA
GNAQ ruxolitinib 0.6391925 0.9385461 0.63919 NA NA
FLCN dabrafenib 0.6398583 0.9389000 0.63986 NA NA
PAX8 nilotinib 0.6400247 0.9389000 0.64002 NA NA
CD79B rucaparib 0.6412203 0.9397255 0.64122 NA NA
IL7R afatinib 0.6415553 0.9397255 0.64156 NA NA
RUNX1 alectinib 0.6416439 0.9397255 0.64164 NA NA
KRAS imatinib 0.6424818 0.9397255 0.64248 NA NA
FGFR3 ruxolitinib 0.6425963 0.9397255 0.64260 NA NA
FGFR2 palbociclib 0.6430949 0.9397255 0.64309 NA NA
SH2B3 palbociclib 0.6434247 0.9397255 0.64342 NA NA
MGMT sunitinib 0.6441449 0.9397255 0.64414 NA NA
PTPN11 dabrafenib 0.6445988 0.9397255 0.64460 NA NA
CD79B trametinib 0.6446579 0.9397255 0.64466 NA NA
EGFR ruxolitinib 0.6447588 0.9397255 0.64476 NA NA
NPM1 rucaparib 0.6448258 0.9397255 0.64483 NA NA
DNMT3A ponatinib 0.6448404 0.9397255 0.64484 NA NA
PHF6 rucaparib 0.6451245 0.9397255 0.64512 NA NA
KRAS lapatinib 0.6456344 0.9397255 0.64563 NA NA
XPO1 ponatinib 0.6457762 0.9397255 0.64578 NA NA
ZRSR2 midostaurin 0.6464003 0.9397255 0.64640 NA NA
MYCN afatinib 0.6464575 0.9397255 0.64646 NA NA
UGT1A1 gefitinib 0.6466857 0.9397255 0.64669 NA NA
EZH2 midostaurin 0.6468498 0.9397255 0.64685 NA NA
PDGFB rucaparib 0.6469333 0.9397255 0.64693 NA NA
PTPN11 trametinib 0.6470969 0.9397255 0.64710 NA NA
CD274 ponatinib 0.6479420 0.9405228 0.64794 NA NA
ALK docetaxel 0.6482988 0.9406108 0.64830 NA NA
CEBPA temozolomide 0.6502677 0.9426490 0.65027 NA NA
PRPF8 sunitinib 0.6502972 0.9426490 0.65030 NA NA
CBLB gefitinib 0.6512627 0.9436178 0.65126 NA NA
PTEN afatinib 0.6523280 0.9440395 0.65233 NA NA
FLT3 midostaurin 0.6526579 0.9440395 0.65266 NA NA
ERBB3 ruxolitinib 0.6532068 0.9440395 0.65321 NA NA
TSC2 gefitinib 0.6534622 0.9440395 0.65346 NA NA
UGT1A1 alectinib 0.6542466 0.9440395 0.65425 NA NA
CTLA4 ruxolitinib 0.6543284 0.9440395 0.65433 NA NA
TSC2 bosutinib monohydrate 0.6543872 0.9440395 0.65439 NA NA
SETBP1 lapatinib 0.6547184 0.9440395 0.65472 NA NA
BCOR pazopanib 0.6547699 0.9440395 0.65477 NA NA
GATA3 belinostat 0.6548206 0.9440395 0.65482 NA NA
MAP2K1 sunitinib 0.6551799 0.9440395 0.65518 NA NA
SF1 trametinib 0.6556570 0.9440395 0.65566 NA NA
SF1 dabrafenib 0.6557616 0.9440395 0.65576 NA NA
SMC1A docetaxel 0.6559586 0.9440395 0.65596 NA NA
STAG2 trametinib 0.6561590 0.9440395 0.65616 NA NA
MDM2 pazopanib 0.6563096 0.9440395 0.65631 NA NA
NOTCH2 alectinib 0.6570045 0.9446113 0.65700 NA NA
SMC1A dabrafenib 0.6573321 0.9446546 0.65733 NA NA
IKZF1 pazopanib 0.6580499 0.9452210 0.65805 NA NA
KIT sunitinib 0.6583214 0.9452210 0.65832 NA NA
MPL trametinib 0.6589843 0.9455176 0.65898 NA NA
FGFR1 nilotinib 0.6591234 0.9455176 0.65912 NA NA
PTCH1 crizotinib 0.6605698 0.9471647 0.66057 NA NA
GATA3 tretinoin 0.6613899 0.9474547 0.66139 NA NA
FGFR3 pazopanib 0.6614324 0.9474547 0.66143 NA NA
CBL bosutinib monohydrate 0.6620191 0.9474547 0.66202 NA NA
IL7R palbociclib 0.6625578 0.9474547 0.66256 NA NA
PDGFRB pazopanib 0.6626651 0.9474547 0.66267 NA NA
JAK1 gefitinib 0.6632200 0.9474547 0.66322 NA NA
FLCN docetaxel 0.6632639 0.9474547 0.66326 NA NA
IDH2 erlotinib 0.6634451 0.9474547 0.66345 NA NA
MGMT temozolomide 0.6634570 0.9474547 0.66346 NA NA
NT5C2 ruxolitinib 0.6648061 0.9483401 0.66481 NA NA
ALK vismodegib 0.6657344 0.9483401 0.66573 NA NA
ASXL1 tretinoin 0.6667178 0.9483401 0.66672 NA NA
CREBBP nilotinib 0.6672208 0.9483401 0.66722 NA NA
PIGA docetaxel 0.6672514 0.9483401 0.66725 NA NA
MYD88 palbociclib 0.6675616 0.9483401 0.66756 NA NA
DDIT3 temozolomide 0.6680811 0.9483401 0.66808 NA NA
GATA2 temozolomide 0.6681305 0.9483401 0.66813 NA NA
BCOR dabrafenib 0.6681638 0.9483401 0.66816 NA NA
CTLA4 midostaurin 0.6682026 0.9483401 0.66820 NA NA
FLT3 belinostat 0.6686147 0.9483401 0.66861 NA NA
FLT3 ponatinib 0.6691061 0.9483401 0.66911 NA NA
SMO cabozantinib 0.6697490 0.9483401 0.66975 NA NA
U2AF1 midostaurin 0.6708859 0.9483401 0.67089 NA NA
CTNNB1 erlotinib 0.6709344 0.9483401 0.67093 NA NA
IDH1 ponatinib 0.6713059 0.9483401 0.67131 NA NA
PDGFB crizotinib 0.6714054 0.9483401 0.67141 NA NA
CTNNB1 crizotinib 0.6714723 0.9483401 0.67147 NA NA
JAK1 belinostat 0.6717499 0.9483401 0.67175 NA NA
DNMT3A dabrafenib 0.6722330 0.9483401 0.67223 NA NA
PRPF40B bosutinib monohydrate 0.6722945 0.9483401 0.67229 NA NA
FLT3 docetaxel 0.6723654 0.9483401 0.67237 NA NA
MET ruxolitinib 0.6724758 0.9483401 0.67248 NA NA
HRAS midostaurin 0.6727624 0.9483401 0.67276 NA NA
ROS1 pazopanib 0.6730661 0.9483401 0.67307 NA NA
CTCF lapatinib 0.6732294 0.9483401 0.67323 NA NA
TET2 trametinib 0.6734045 0.9483401 0.67340 NA NA
CBL pazopanib 0.6735525 0.9483401 0.67355 NA NA
CXCR4 belinostat 0.6735809 0.9483401 0.67358 NA NA
MAP2K1 palbociclib 0.6736365 0.9483401 0.67364 NA NA
NRAS rucaparib 0.6737269 0.9483401 0.67373 NA NA
BRCA2 nilotinib 0.6739857 0.9483401 0.67399 NA NA
XPO1 cabozantinib 0.6741548 0.9483401 0.67415 NA NA
HRAS afatinib 0.6742292 0.9483401 0.67423 NA NA
JAK3 vismodegib 0.6747353 0.9485643 0.67474 NA NA
ROS1 temozolomide 0.6751390 0.9485643 0.67514 NA NA
PML gefitinib 0.6752846 0.9485643 0.67528 NA NA
PDCD1 belinostat 0.6759501 0.9487916 0.67595 NA NA
CDK4 rucaparib 0.6760802 0.9487916 0.67608 NA NA
SH2B3 temozolomide 0.6764609 0.9487916 0.67646 NA NA
AKT1 rucaparib 0.6766724 0.9487916 0.67667 NA NA
CDKN2A nilotinib 0.6769401 0.9487916 0.67694 NA NA
CRLF2 nilotinib 0.6773888 0.9488401 0.67739 NA NA
EML4 trametinib 0.6775722 0.9488401 0.67757 NA NA
EGFR belinostat 0.6783585 0.9493302 0.67836 NA NA
STAT3 lapatinib 0.6790984 0.9493302 0.67910 NA NA
NT5C2 bosutinib monohydrate 0.6791919 0.9493302 0.67919 NA NA
CDKN2A sunitinib 0.6799349 0.9493302 0.67993 NA NA
ESR1 dasatinib 0.6806688 0.9493302 0.68067 NA NA
PAX5 nilotinib 0.6809647 0.9493302 0.68096 NA NA
SF1 midostaurin 0.6811779 0.9493302 0.68118 NA NA
ERBB2 rucaparib 0.6813788 0.9493302 0.68138 NA NA
ESR1 lapatinib 0.6823352 0.9493302 0.68234 NA NA
PDGFRA erlotinib 0.6824019 0.9493302 0.68240 NA NA
PDGFRA ponatinib 0.6831311 0.9493302 0.68313 NA NA
ESR1 midostaurin 0.6835330 0.9493302 0.68353 NA NA
CEBPA dabrafenib 0.6842945 0.9493302 0.68429 NA NA
ESR1 tretinoin 0.6845216 0.9493302 0.68452 NA NA
BRCA1 dabrafenib 0.6846752 0.9493302 0.68468 NA NA
KRAS rucaparib 0.6847697 0.9493302 0.68477 NA NA
BRCA1 palbociclib 0.6850052 0.9493302 0.68501 NA NA
CBLB nilotinib 0.6856568 0.9493302 0.68566 NA NA
SF3B1 belinostat 0.6860819 0.9493302 0.68608 NA NA
CD79B erlotinib 0.6861034 0.9493302 0.68610 NA NA
DNAJB1 erlotinib 0.6861034 0.9493302 0.68610 NA NA
GNAQ erlotinib 0.6861034 0.9493302 0.68610 NA NA
MPL erlotinib 0.6862166 0.9493302 0.68622 NA NA
NOTCH2 erlotinib 0.6862166 0.9493302 0.68622 NA NA
FBXW7 tretinoin 0.6863672 0.9493302 0.68637 NA NA
IDH1 pazopanib 0.6864256 0.9493302 0.68643 NA NA
FGFR3 imatinib 0.6868047 0.9493302 0.68680 NA NA
CALR gefitinib 0.6884355 0.9493302 0.68844 NA NA
JAK1 trametinib 0.6886991 0.9493302 0.68870 NA NA
ERBB4 nilotinib 0.6889474 0.9493302 0.68895 NA NA
RET belinostat 0.6890334 0.9493302 0.68903 NA NA
RAD21 docetaxel 0.6893317 0.9493302 0.68933 NA NA
U2AF1 dasatinib 0.6894250 0.9493302 0.68943 NA NA
IKZF1 cabozantinib 0.6895685 0.9493302 0.68957 NA NA
MYD88 crizotinib 0.6896981 0.9493302 0.68970 NA NA
PHF6 bosutinib monohydrate 0.6899414 0.9493302 0.68994 NA NA
GATA3 ponatinib 0.6899584 0.9493302 0.68996 NA NA
IL7R dabrafenib 0.6901632 0.9493302 0.69016 NA NA
CYP19A1 bosutinib monohydrate 0.6902719 0.9493302 0.69027 NA NA
MGMT pazopanib 0.6911734 0.9493302 0.69117 NA NA
EML4 midostaurin 0.6914164 0.9493302 0.69142 NA NA
RUNX1 pazopanib 0.6915374 0.9493302 0.69154 NA NA
ALK alectinib 0.6916060 0.9493302 0.69161 NA NA
MET temozolomide 0.6917583 0.9493302 0.69176 NA NA
ESR1 pazopanib 0.6922709 0.9493302 0.69227 NA NA
PML cabozantinib 0.6926459 0.9493302 0.69265 NA NA
PAX8 vismodegib 0.6926534 0.9493302 0.69265 NA NA
CD274 bosutinib monohydrate 0.6927838 0.9493302 0.69278 NA NA
PDGFB cabozantinib 0.6931930 0.9493302 0.69319 NA NA
SF3B1 ruxolitinib 0.6933953 0.9493302 0.69340 NA NA
PTEN bosutinib monohydrate 0.6935476 0.9493302 0.69355 NA NA
EZH2 sunitinib 0.6938567 0.9493302 0.69386 NA NA
CALR afatinib 0.6938848 0.9493302 0.69388 NA NA
NCOA2 dasatinib 0.6940632 0.9493302 0.69406 NA NA
CSF3R gefitinib 0.6946468 0.9496794 0.69465 NA NA
RAD21 lapatinib 0.6950648 0.9496794 0.69506 NA NA
SSX1 afatinib 0.6952155 0.9496794 0.69522 NA NA
PRPF8 palbociclib 0.6959597 0.9499624 0.69596 NA NA
ESR1 trametinib 0.6962680 0.9499624 0.69627 NA NA
RAD21 imatinib 0.6963200 0.9499624 0.69632 NA NA
SMC3 trametinib 0.6972222 0.9506681 0.69722 NA NA
CDKN2A cabozantinib 0.6975307 0.9506681 0.69753 NA NA
SF3B1 alectinib 0.6977353 0.9506681 0.69774 NA NA
FGFR2 gefitinib 0.6980616 0.9507048 0.69806 NA NA
ABL1 temozolomide 0.6987934 0.9508786 0.69879 NA NA
CTLA4 pazopanib 0.6992202 0.9508786 0.69922 NA NA
BRCA1 docetaxel 0.7001716 0.9508786 0.70017 NA NA
SMC1A trametinib 0.7004160 0.9508786 0.70042 NA NA
GATA1 belinostat 0.7010507 0.9508786 0.70105 NA NA
BRCA1 crizotinib 0.7017863 0.9508786 0.70179 NA NA
CRLF2 temozolomide 0.7018756 0.9508786 0.70188 NA NA
TET2 belinostat 0.7026106 0.9508786 0.70261 NA NA
PML dasatinib 0.7028188 0.9508786 0.70282 NA NA
KMT2A afatinib 0.7030506 0.9508786 0.70305 NA NA
NOTCH2 sunitinib 0.7032998 0.9508786 0.70330 NA NA
TSC1 dasatinib 0.7033301 0.9508786 0.70333 NA NA
EZH2 trametinib 0.7036019 0.9508786 0.70360 NA NA
ETV6 midostaurin 0.7039964 0.9508786 0.70400 NA NA
G6PD crizotinib 0.7040235 0.9508786 0.70402 NA NA
TET2 palbociclib 0.7041197 0.9508786 0.70412 NA NA
GNB1 tretinoin 0.7042251 0.9508786 0.70423 NA NA
HRAS dabrafenib 0.7049847 0.9508786 0.70498 NA NA
FLCN palbociclib 0.7051976 0.9508786 0.70520 NA NA
ERBB2 docetaxel 0.7052502 0.9508786 0.70525 NA NA
SRSF2 trametinib 0.7053488 0.9508786 0.70535 NA NA
GNAS afatinib 0.7054184 0.9508786 0.70542 NA NA
WT1 afatinib 0.7062470 0.9508786 0.70625 NA NA
UGT1A1 ponatinib 0.7062488 0.9508786 0.70625 NA NA
CTNNB1 tretinoin 0.7063175 0.9508786 0.70632 NA NA
CSF3R afatinib 0.7063490 0.9508786 0.70635 NA NA
CBL tretinoin 0.7065815 0.9508786 0.70658 NA NA
STAT3 docetaxel 0.7071045 0.9508786 0.70710 NA NA
IL7R cabozantinib 0.7075726 0.9508786 0.70757 NA NA
ROS1 vismodegib 0.7075936 0.9508786 0.70759 NA NA
ERBB2 palbociclib 0.7083268 0.9508786 0.70833 NA NA
FBXW7 sunitinib 0.7083621 0.9508786 0.70836 NA NA
NOTCH1 midostaurin 0.7089128 0.9508786 0.70891 NA NA
TSC2 belinostat 0.7089749 0.9508786 0.70897 NA NA
IDH2 dasatinib 0.7090830 0.9508786 0.70908 NA NA
PRPF40B cabozantinib 0.7092004 0.9508786 0.70920 NA NA
ALK erlotinib 0.7099827 0.9508786 0.70998 NA NA
JAK2 dasatinib 0.7103203 0.9508786 0.71032 NA NA
RET dabrafenib 0.7105653 0.9508786 0.71057 NA NA
FGFR2 rucaparib 0.7108197 0.9508786 0.71082 NA NA
GATA3 pazopanib 0.7109684 0.9508786 0.71097 NA NA
HRAS rucaparib 0.7110377 0.9508786 0.71104 NA NA
U2AF1 dabrafenib 0.7110632 0.9508786 0.71106 NA NA
STAG2 docetaxel 0.7117563 0.9510210 0.71176 NA NA
RUNX1 crizotinib 0.7117686 0.9510210 0.71177 NA NA
PIK3CA alectinib 0.7127369 0.9518052 0.71274 NA NA
BTK midostaurin 0.7129549 0.9518052 0.71295 NA NA
KRAS ruxolitinib 0.7137147 0.9519250 0.71371 NA NA
SETBP1 dasatinib 0.7145822 0.9519250 0.71458 NA NA
WT1 ponatinib 0.7147828 0.9519250 0.71478 NA NA
RET dasatinib 0.7148163 0.9519250 0.71482 NA NA
IKZF1 lapatinib 0.7149708 0.9519250 0.71497 NA NA
KRAS temozolomide 0.7150718 0.9519250 0.71507 NA NA
SF3B1 dabrafenib 0.7152721 0.9519250 0.71527 NA NA
ESR1 cabozantinib 0.7161231 0.9519250 0.71612 NA NA
ERBB4 midostaurin 0.7168444 0.9519250 0.71684 NA NA
BTK dasatinib 0.7173351 0.9519250 0.71734 NA NA
PAX8 dasatinib 0.7173351 0.9519250 0.71734 NA NA
FGFR1 vismodegib 0.7176988 0.9519250 0.71770 NA NA
WHSC1 pazopanib 0.7177667 0.9519250 0.71777 NA NA
CDK4 ponatinib 0.7179383 0.9519250 0.71794 NA NA
CBL trametinib 0.7179539 0.9519250 0.71795 NA NA
CRLF2 trametinib 0.7189639 0.9519250 0.71896 NA NA
SETBP1 ruxolitinib 0.7191346 0.9519250 0.71913 NA NA
AR belinostat 0.7191374 0.9519250 0.71914 NA NA
PAX8 tretinoin 0.7192167 0.9519250 0.71922 NA NA
EGFR trametinib 0.7194767 0.9519250 0.71948 NA NA
NRAS temozolomide 0.7197845 0.9519250 0.71978 NA NA
PTCH1 vismodegib 0.7198241 0.9519250 0.71982 NA NA
JAK3 pazopanib 0.7199383 0.9519250 0.71994 NA NA
ERBB3 erlotinib 0.7203169 0.9519798 0.72032 NA NA
HRAS temozolomide 0.7205791 0.9519798 0.72058 NA NA
SMO dabrafenib 0.7212576 0.9524799 0.72126 NA NA
MYCN palbociclib 0.7218549 0.9525777 0.72185 NA NA
CD274 palbociclib 0.7221370 0.9525777 0.72214 NA NA
CD274 gefitinib 0.7222314 0.9525777 0.72223 NA NA
MAP2K1 gefitinib 0.7231455 0.9533874 0.72315 NA NA
SMO sunitinib 0.7239446 0.9537902 0.72394 NA NA
PDGFRB ponatinib 0.7240517 0.9537902 0.72405 NA NA
RUNX1 gefitinib 0.7245837 0.9538586 0.72458 NA NA
SMO pazopanib 0.7247577 0.9538586 0.72476 NA NA
MAP2K1 pazopanib 0.7253435 0.9538586 0.72534 NA NA
NOTCH1 crizotinib 0.7257254 0.9538586 0.72573 NA NA
EED midostaurin 0.7259376 0.9538586 0.72594 NA NA
FLCN vismodegib 0.7262828 0.9538586 0.72628 NA NA
ERBB3 rucaparib 0.7263040 0.9538586 0.72630 NA NA
GNA11 dabrafenib 0.7266549 0.9538586 0.72665 NA NA
PHF6 vismodegib 0.7268066 0.9538586 0.72681 NA NA
MDM2 vismodegib 0.7273768 0.9538611 0.72738 NA NA
CBLB tretinoin 0.7276859 0.9538611 0.72769 NA NA
GNAQ gefitinib 0.7280594 0.9538611 0.72806 NA NA
FGFR2 ruxolitinib 0.7282503 0.9538611 0.72825 NA NA
DPYD pazopanib 0.7284979 0.9538611 0.72850 NA NA
EML4 afatinib 0.7287764 0.9538611 0.72878 NA NA
PRPF8 bosutinib monohydrate 0.7291900 0.9538611 0.72919 NA NA
SMC3 pazopanib 0.7292112 0.9538611 0.72921 NA NA
PDGFRB palbociclib 0.7303977 0.9547064 0.73040 NA NA
ABL1 nilotinib 0.7313136 0.9547064 0.73131 NA NA
GATA3 docetaxel 0.7316455 0.9547064 0.73165 NA NA
NT5C2 erlotinib 0.7318780 0.9547064 0.73188 NA NA
RUNX1 erlotinib 0.7318780 0.9547064 0.73188 NA NA
CXCR4 vismodegib 0.7331174 0.9547064 0.73312 NA NA
BRAF temozolomide 0.7335771 0.9547064 0.73358 NA NA
GATA2 ponatinib 0.7335798 0.9547064 0.73358 NA NA
PIK3CA vismodegib 0.7343535 0.9547064 0.73435 NA NA
EGFR docetaxel 0.7346881 0.9547064 0.73469 NA NA
FLCN ponatinib 0.7349618 0.9547064 0.73496 NA NA
PML ruxolitinib 0.7351319 0.9547064 0.73513 NA NA
FANCL rucaparib 0.7358289 0.9547064 0.73583 NA NA
CBLB pazopanib 0.7358844 0.9547064 0.73588 NA NA
IL7R gefitinib 0.7358963 0.9547064 0.73590 NA NA
WT1 alectinib 0.7365097 0.9547064 0.73651 NA NA
FANCL sunitinib 0.7369648 0.9547064 0.73696 NA NA
CBL ponatinib 0.7373495 0.9547064 0.73735 NA NA
CEBPA docetaxel 0.7376323 0.9547064 0.73763 NA NA
CYP19A1 temozolomide 0.7376987 0.9547064 0.73770 NA NA
CDK4 tretinoin 0.7381800 0.9547064 0.73818 NA NA
PAX5 midostaurin 0.7382339 0.9547064 0.73823 NA NA
PRPF40B ponatinib 0.7385033 0.9547064 0.73850 NA NA
PDGFRA crizotinib 0.7390621 0.9547064 0.73906 NA NA
CREBBP crizotinib 0.7392861 0.9547064 0.73929 NA NA
FLCN nilotinib 0.7393663 0.9547064 0.73937 NA NA
SETBP1 tretinoin 0.7395737 0.9547064 0.73957 NA NA
CSF3R rucaparib 0.7397162 0.9547064 0.73972 NA NA
EGF sunitinib 0.7398358 0.9547064 0.73984 NA NA
IL7R sunitinib 0.7398358 0.9547064 0.73984 NA NA
KIT dasatinib 0.7398951 0.9547064 0.73990 NA NA
CDK4 belinostat 0.7399640 0.9547064 0.73996 NA NA
ERBB3 crizotinib 0.7406129 0.9547064 0.74061 NA NA
AKT1 afatinib 0.7407741 0.9547064 0.74077 NA NA
CALR vismodegib 0.7414134 0.9547064 0.74141 NA NA
DPYD sunitinib 0.7414533 0.9547064 0.74145 NA NA
KRAS bosutinib monohydrate 0.7414809 0.9547064 0.74148 NA NA
CTLA4 dabrafenib 0.7416236 0.9547064 0.74162 NA NA
TSC1 cabozantinib 0.7417760 0.9547064 0.74178 NA NA
PIGA tretinoin 0.7420835 0.9547064 0.74208 NA NA
CYP19A1 ponatinib 0.7421820 0.9547064 0.74218 NA NA
PDGFRB bosutinib monohydrate 0.7429860 0.9547601 0.74299 NA NA
GATA3 afatinib 0.7430967 0.9547601 0.74310 NA NA
NOTCH2 palbociclib 0.7431256 0.9547601 0.74313 NA NA
IDH2 imatinib 0.7435570 0.9549281 0.74356 NA NA
FANCL bosutinib monohydrate 0.7442638 0.9554494 0.74426 NA NA
CSF3R imatinib 0.7445896 0.9554815 0.74459 NA NA
PDGFRA belinostat 0.7450686 0.9557100 0.74507 NA NA
ASXL1 lapatinib 0.7456852 0.9558452 0.74569 NA NA
TPMT midostaurin 0.7460273 0.9558452 0.74603 NA NA
JAK3 crizotinib 0.7461407 0.9558452 0.74614 NA NA
PML belinostat 0.7463779 0.9558452 0.74638 NA NA
FBXW7 dabrafenib 0.7471349 0.9564291 0.74713 NA NA
SMO bosutinib monohydrate 0.7478513 0.9568582 0.74785 NA NA
SETD2 tretinoin 0.7482992 0.9568582 0.74830 NA NA
GATA2 imatinib 0.7483981 0.9568582 0.74840 NA NA
ATM rucaparib 0.7486752 0.9568582 0.74868 NA NA
BRCA1 imatinib 0.7500850 0.9578756 0.75008 NA NA
KIT imatinib 0.7505218 0.9578756 0.75052 NA NA
NOTCH1 belinostat 0.7507540 0.9578756 0.75075 NA NA
PDCD1 midostaurin 0.7514117 0.9578756 0.75141 NA NA
EGFR palbociclib 0.7514260 0.9578756 0.75143 NA NA
SETBP1 erlotinib 0.7514881 0.9578756 0.75149 NA NA
BTK cabozantinib 0.7515825 0.9578756 0.75158 NA NA
CDC73 midostaurin 0.7520422 0.9578798 0.75204 NA NA
MAP2K1 rucaparib 0.7521890 0.9578798 0.75219 NA NA
ERBB4 tretinoin 0.7532253 0.9580745 0.75323 NA NA
PHF6 ruxolitinib 0.7532871 0.9580745 0.75329 NA NA
MAP2K2 afatinib 0.7534845 0.9580745 0.75348 NA NA
ERBB4 dabrafenib 0.7535485 0.9580745 0.75355 NA NA
CREBBP belinostat 0.7547871 0.9592653 0.75479 NA NA
DNMT3A bosutinib monohydrate 0.7551741 0.9593731 0.75517 NA NA
SSX1 dabrafenib 0.7561779 0.9600555 0.75618 NA NA
MYCN vismodegib 0.7563157 0.9600555 0.75632 NA NA
NT5C2 ponatinib 0.7573545 0.9606710 0.75735 NA NA
MAP2K1 lapatinib 0.7574056 0.9606710 0.75741 NA NA
WHSC1 gefitinib 0.7582570 0.9610535 0.75826 NA NA
PDGFRA pazopanib 0.7583124 0.9610535 0.75831 NA NA
FGFR1 bosutinib monohydrate 0.7589059 0.9610856 0.75891 NA NA
CTNNB1 pazopanib 0.7592589 0.9610856 0.75926 NA NA
PIGA alectinib 0.7603016 0.9610856 0.76030 NA NA
PAX8 rucaparib 0.7606800 0.9610856 0.76068 NA NA
PTEN nilotinib 0.7611038 0.9610856 0.76110 NA NA
FANCL midostaurin 0.7611087 0.9610856 0.76111 NA NA
DNMT3A alectinib 0.7613631 0.9610856 0.76136 NA NA
TPMT rucaparib 0.7619662 0.9610856 0.76197 NA NA
GNAS imatinib 0.7623301 0.9610856 0.76233 NA NA
STAG2 rucaparib 0.7624445 0.9610856 0.76244 NA NA
AKT1 gefitinib 0.7625117 0.9610856 0.76251 NA NA
CDKN2A dasatinib 0.7625887 0.9610856 0.76259 NA NA
NCOA2 trametinib 0.7627476 0.9610856 0.76275 NA NA
G6PD trametinib 0.7631155 0.9610856 0.76312 NA NA
EGFR pazopanib 0.7631271 0.9610856 0.76313 NA NA
MGMT alectinib 0.7636616 0.9610856 0.76366 NA NA
PDGFB bosutinib monohydrate 0.7637526 0.9610856 0.76375 NA NA
KRAS sunitinib 0.7642647 0.9610856 0.76426 NA NA
CXCR4 cabozantinib 0.7645614 0.9610856 0.76456 NA NA
CTNNB1 gefitinib 0.7648316 0.9610856 0.76483 NA NA
PDGFRB gefitinib 0.7649324 0.9610856 0.76493 NA NA
WT1 cabozantinib 0.7656627 0.9610856 0.76566 NA NA
IDH1 bosutinib monohydrate 0.7658117 0.9610856 0.76581 NA NA
CBLB alectinib 0.7661083 0.9610856 0.76611 NA NA
IL7R imatinib 0.7661566 0.9610856 0.76616 NA NA
AKT2 lapatinib 0.7662055 0.9610856 0.76621 NA NA
CSF3R nilotinib 0.7665100 0.9610880 0.76651 NA NA
TPMT palbociclib 0.7668585 0.9611454 0.76686 NA NA
CYP19A1 palbociclib 0.7672395 0.9612437 0.76724 NA NA
ASXL1 temozolomide 0.7680740 0.9618479 0.76807 NA NA
CD79B pazopanib 0.7683275 0.9618479 0.76833 NA NA
PHF6 pazopanib 0.7688041 0.9620654 0.76880 NA NA
ETV6 bosutinib monohydrate 0.7705523 0.9638321 0.77055 NA NA
ABL1 bosutinib monohydrate 0.7708229 0.9638321 0.77082 NA NA
ALK tretinoin 0.7717427 0.9638929 0.77174 NA NA
PDGFRA lapatinib 0.7718304 0.9638929 0.77183 NA NA
RIT1 ruxolitinib 0.7720357 0.9638929 0.77204 NA NA
PDGFB pazopanib 0.7722360 0.9638929 0.77224 NA NA
AKT2 afatinib 0.7723890 0.9638929 0.77239 NA NA
SH2B3 trametinib 0.7727573 0.9639738 0.77276 NA NA
GNAQ palbociclib 0.7733014 0.9642737 0.77330 NA NA
SETBP1 midostaurin 0.7737089 0.9643370 0.77371 NA NA
ERBB2 vismodegib 0.7739594 0.9643370 0.77396 NA NA
KIT docetaxel 0.7747007 0.9648821 0.77470 NA NA
CDKN2A vismodegib 0.7751324 0.9649138 0.77513 NA NA
FGFR3 ponatinib 0.7753615 0.9649138 0.77536 NA NA
SSX1 belinostat 0.7759031 0.9649138 0.77590 NA NA
U2AF1 sunitinib 0.7759414 0.9649138 0.77594 NA NA
SMC3 crizotinib 0.7765258 0.9652626 0.77653 NA NA
PML nilotinib 0.7777017 0.9663461 0.77770 NA NA
IKZF1 palbociclib 0.7792127 0.9665666 0.77921 NA NA
GATA2 rucaparib 0.7793422 0.9665666 0.77934 NA NA
JAK1 rucaparib 0.7793843 0.9665666 0.77938 NA NA
EGF crizotinib 0.7795860 0.9665666 0.77959 NA NA
STAT3 dabrafenib 0.7798325 0.9665666 0.77983 NA NA
DPYD tretinoin 0.7806169 0.9665666 0.78062 NA NA
KMT2A midostaurin 0.7807486 0.9665666 0.78075 NA NA
JAK1 dasatinib 0.7807932 0.9665666 0.78079 NA NA
EGF lapatinib 0.7810119 0.9665666 0.78101 NA NA
EGFR rucaparib 0.7812134 0.9665666 0.78121 NA NA
TP53 alectinib 0.7812268 0.9665666 0.78123 NA NA
RAD21 midostaurin 0.7818238 0.9665981 0.78182 NA NA
RUNX1 midostaurin 0.7821353 0.9665981 0.78214 NA NA
ETV6 palbociclib 0.7821653 0.9665981 0.78217 NA NA
SSX1 cabozantinib 0.7843612 0.9689347 0.78436 NA NA
PRPF8 docetaxel 0.7851088 0.9692570 0.78511 NA NA
MET rucaparib 0.7852325 0.9692570 0.78523 NA NA
MYD88 sunitinib 0.7863908 0.9701455 0.78639 NA NA
IDH1 temozolomide 0.7871872 0.9701455 0.78719 NA NA
CD79B nilotinib 0.7872284 0.9701455 0.78723 NA NA
CXCR4 tretinoin 0.7873492 0.9701455 0.78735 NA NA
CBLB ponatinib 0.7877705 0.9701455 0.78777 NA NA
CTLA4 belinostat 0.7879627 0.9701455 0.78796 NA NA
NPM1 pazopanib 0.7880905 0.9701455 0.78809 NA NA
MYD88 imatinib 0.7889569 0.9708358 0.78896 NA NA
SH2B3 docetaxel 0.7897952 0.9714909 0.78980 NA NA
BRAF ponatinib 0.7903167 0.9717560 0.79032 NA NA
ASXL1 midostaurin 0.7907471 0.9719090 0.79075 NA NA
WHSC1 lapatinib 0.7912577 0.9721494 0.79126 NA NA
WHSC1 bosutinib monohydrate 0.7917104 0.9721494 0.79171 NA NA
BRCA1 gefitinib 0.7929047 0.9721494 0.79290 NA NA
TP53 sunitinib 0.7929103 0.9721494 0.79291 NA NA
DDIT3 afatinib 0.7931329 0.9721494 0.79313 NA NA
JAK1 bosutinib monohydrate 0.7934737 0.9721494 0.79347 NA NA
EGF vismodegib 0.7936091 0.9721494 0.79361 NA NA
NOTCH1 dabrafenib 0.7939637 0.9721494 0.79396 NA NA
SSX1 ruxolitinib 0.7939998 0.9721494 0.79400 NA NA
FLT3 alectinib 0.7941809 0.9721494 0.79418 NA NA
BRAF midostaurin 0.7943467 0.9721494 0.79435 NA NA
PAX8 pazopanib 0.7947477 0.9721494 0.79475 NA NA
AKT2 nilotinib 0.7949272 0.9721494 0.79493 NA NA
PTCH1 rucaparib 0.7952280 0.9721494 0.79523 NA NA
SH2B3 pazopanib 0.7956485 0.9722775 0.79565 NA NA
CDK6 bosutinib monohydrate 0.7961993 0.9722775 0.79620 NA NA
AKT2 vismodegib 0.7962512 0.9722775 0.79625 NA NA
MAP2K1 dasatinib 0.7966385 0.9723766 0.79664 NA NA
BCORL1 trametinib 0.7977582 0.9724415 0.79776 NA NA
PML docetaxel 0.7980096 0.9724415 0.79801 NA NA
AKT2 belinostat 0.7986070 0.9724415 0.79861 NA NA
ERBB4 ruxolitinib 0.7989163 0.9724415 0.79892 NA NA
AKT3 nilotinib 0.7991714 0.9724415 0.79917 NA NA
PRPF8 dasatinib 0.7991729 0.9724415 0.79917 NA NA
AKT2 pazopanib 0.7992674 0.9724415 0.79927 NA NA
BCOR docetaxel 0.7999167 0.9724415 0.79992 NA NA
SF1 lapatinib 0.8001540 0.9724415 0.80015 NA NA
NPM1 vismodegib 0.8004491 0.9724415 0.80045 NA NA
GATA3 gefitinib 0.8010561 0.9724415 0.80106 NA NA
SSX1 bosutinib monohydrate 0.8010644 0.9724415 0.80106 NA NA
DNAJB1 ruxolitinib 0.8017173 0.9724415 0.80172 NA NA
PDGFRB crizotinib 0.8019048 0.9724415 0.80190 NA NA
ERBB3 trametinib 0.8021031 0.9724415 0.80210 NA NA
MYCN belinostat 0.8021438 0.9724415 0.80214 NA NA
NOTCH1 cabozantinib 0.8021819 0.9724415 0.80218 NA NA
CDKN2A tretinoin 0.8022030 0.9724415 0.80220 NA NA
ERBB4 bosutinib monohydrate 0.8029349 0.9729574 0.80293 NA NA
NOTCH2 ponatinib 0.8034028 0.9730164 0.80340 NA NA
FLT3 afatinib 0.8043606 0.9730164 0.80436 NA NA
FLCN tretinoin 0.8043691 0.9730164 0.80437 NA NA
SETD2 palbociclib 0.8046290 0.9730164 0.80463 NA NA
JAK2 sunitinib 0.8046870 0.9730164 0.80469 NA NA
MPL lapatinib 0.8048218 0.9730164 0.80482 NA NA
STAT3 bosutinib monohydrate 0.8055766 0.9730983 0.80558 NA NA
PTPN11 pazopanib 0.8056289 0.9730983 0.80563 NA NA
KRAS nilotinib 0.8058237 0.9730983 0.80582 NA NA
IDH2 nilotinib 0.8061151 0.9730983 0.80612 NA NA
IDH2 ruxolitinib 0.8073056 0.9732165 0.80731 NA NA
HRAS gefitinib 0.8076126 0.9732165 0.80761 NA NA
FLT3 tretinoin 0.8076478 0.9732165 0.80765 NA NA
DPYD belinostat 0.8079628 0.9732165 0.80796 NA NA
ESR1 bosutinib monohydrate 0.8080005 0.9732165 0.80800 NA NA
CTLA4 trametinib 0.8080516 0.9732165 0.80805 NA NA
NRAS docetaxel 0.8083668 0.9732271 0.80837 NA NA
U2AF1 gefitinib 0.8094477 0.9739554 0.80945 NA NA
SETD2 belinostat 0.8095851 0.9739554 0.80959 NA NA
AKT3 rucaparib 0.8101446 0.9742595 0.81014 NA NA
PIGA lapatinib 0.8104666 0.9742777 0.81047 NA NA
DPYD palbociclib 0.8111267 0.9743982 0.81113 NA NA
IKZF1 belinostat 0.8113724 0.9743982 0.81137 NA NA
PTPN11 vismodegib 0.8117817 0.9743982 0.81178 NA NA
IL7R vismodegib 0.8119458 0.9743982 0.81195 NA NA
NT5C2 trametinib 0.8128743 0.9743982 0.81287 NA NA
AR docetaxel 0.8129175 0.9743982 0.81292 NA NA
WHSC1 rucaparib 0.8131544 0.9743982 0.81315 NA NA
VHL docetaxel 0.8136685 0.9743982 0.81367 NA NA
PTEN dabrafenib 0.8142047 0.9743982 0.81420 NA NA
GNA11 temozolomide 0.8144730 0.9743982 0.81447 NA NA
PRPF8 dabrafenib 0.8146043 0.9743982 0.81460 NA NA
HRAS docetaxel 0.8151657 0.9743982 0.81517 NA NA
CREBBP lapatinib 0.8151862 0.9743982 0.81519 NA NA
NOTCH1 imatinib 0.8157654 0.9743982 0.81577 NA NA
RET temozolomide 0.8158960 0.9743982 0.81590 NA NA
XPO1 gefitinib 0.8161735 0.9743982 0.81617 NA NA
TET2 pazopanib 0.8164348 0.9743982 0.81643 NA NA
BRCA1 sunitinib 0.8165800 0.9743982 0.81658 NA NA
PHF6 midostaurin 0.8168214 0.9743982 0.81682 NA NA
PTPN11 tretinoin 0.8170201 0.9743982 0.81702 NA NA
PRPF40B lapatinib 0.8171082 0.9743982 0.81711 NA NA
ETV6 docetaxel 0.8173164 0.9743982 0.81732 NA NA
ZRSR2 erlotinib 0.8179957 0.9744526 0.81800 NA NA
ERBB3 dasatinib 0.8180600 0.9744526 0.81806 NA NA
PRPF8 nilotinib 0.8182825 0.9744526 0.81828 NA NA
G6PD gefitinib 0.8202116 0.9752458 0.82021 NA NA
ETV6 dasatinib 0.8204783 0.9752458 0.82048 NA NA
CREBBP erlotinib 0.8208508 0.9752458 0.82085 NA NA
CREBBP bosutinib monohydrate 0.8213056 0.9752458 0.82131 NA NA
AKT2 cabozantinib 0.8215110 0.9752458 0.82151 NA NA
SRSF2 bosutinib monohydrate 0.8216022 0.9752458 0.82160 NA NA
PHF6 temozolomide 0.8222578 0.9752458 0.82226 NA NA
NCOA2 afatinib 0.8224551 0.9752458 0.82246 NA NA
PIK3CA pazopanib 0.8224888 0.9752458 0.82249 NA NA
KMT2A lapatinib 0.8228845 0.9752458 0.82288 NA NA
ZRSR2 crizotinib 0.8231357 0.9752458 0.82314 NA NA
WHSC1 crizotinib 0.8232275 0.9752458 0.82323 NA NA
PRPF8 afatinib 0.8232418 0.9752458 0.82324 NA NA
ERBB4 sunitinib 0.8233327 0.9752458 0.82333 NA NA
FLT3 palbociclib 0.8239049 0.9752458 0.82390 NA NA
EGFR bosutinib monohydrate 0.8249647 0.9752458 0.82496 NA NA
BRCA1 pazopanib 0.8251732 0.9752458 0.82517 NA NA
TET2 rucaparib 0.8260219 0.9752458 0.82602 NA NA
MET alectinib 0.8262519 0.9752458 0.82625 NA NA
NOTCH1 tretinoin 0.8264829 0.9752458 0.82648 NA NA
G6PD cabozantinib 0.8264953 0.9752458 0.82650 NA NA
NCOA2 sunitinib 0.8265853 0.9752458 0.82659 NA NA
ERBB3 sunitinib 0.8272393 0.9752458 0.82724 NA NA
TSC1 dabrafenib 0.8273766 0.9752458 0.82738 NA NA
STAG2 palbociclib 0.8274365 0.9752458 0.82744 NA NA
CD79B midostaurin 0.8277512 0.9752458 0.82775 NA NA
PHF6 trametinib 0.8279218 0.9752458 0.82792 NA NA
VHL ponatinib 0.8280799 0.9752458 0.82808 NA NA
G6PD midostaurin 0.8281741 0.9752458 0.82817 NA NA
EML4 dabrafenib 0.8284492 0.9752458 0.82845 NA NA
NCOA2 ponatinib 0.8286775 0.9752458 0.82868 NA NA
FGFR1 lapatinib 0.8287747 0.9752458 0.82877 NA NA
KMT2A pazopanib 0.8299580 0.9762765 0.82996 NA NA
FLT3 ruxolitinib 0.8312495 0.9770529 0.83125 NA NA
MET trametinib 0.8326323 0.9770529 0.83263 NA NA
WHSC1 midostaurin 0.8326953 0.9770529 0.83270 NA NA
MAP2K1 belinostat 0.8327077 0.9770529 0.83271 NA NA
EML4 pazopanib 0.8328229 0.9770529 0.83282 NA NA
NCOA2 cabozantinib 0.8330328 0.9770529 0.83303 NA NA
FBXW7 ruxolitinib 0.8330920 0.9770529 0.83309 NA NA
BRCA1 cabozantinib 0.8333837 0.9770529 0.83338 NA NA
RIT1 pazopanib 0.8336905 0.9770529 0.83369 NA NA
GATA2 midostaurin 0.8338411 0.9770529 0.83384 NA NA
CXCR4 trametinib 0.8340020 0.9770529 0.83400 NA NA
CTCF dasatinib 0.8347924 0.9771109 0.83479 NA NA
MGMT tretinoin 0.8349168 0.9771109 0.83492 NA NA
CYP19A1 rucaparib 0.8350834 0.9771109 0.83508 NA NA
GNA11 bosutinib monohydrate 0.8354619 0.9771109 0.83546 NA NA
MET midostaurin 0.8355898 0.9771109 0.83559 NA NA
ETV6 cabozantinib 0.8369112 0.9782959 0.83691 NA NA
SRSF2 pazopanib 0.8374135 0.9785229 0.83741 NA NA
SMC1A tretinoin 0.8382380 0.9789018 0.83824 NA NA
CDK4 alectinib 0.8384108 0.9789018 0.83841 NA NA
CDK6 docetaxel 0.8387669 0.9789018 0.83877 NA NA
ASXL1 imatinib 0.8389707 0.9789018 0.83897 NA NA
GNAS trametinib 0.8402119 0.9794986 0.84021 NA NA
CALR palbociclib 0.8402810 0.9794986 0.84028 NA NA
CBL alectinib 0.8404483 0.9794986 0.84045 NA NA
FANCL docetaxel 0.8407316 0.9794986 0.84073 NA NA
MAP2K2 temozolomide 0.8411007 0.9794986 0.84110 NA NA
CBLB crizotinib 0.8413325 0.9794986 0.84133 NA NA
RET rucaparib 0.8423514 0.9801808 0.84235 NA NA
BRAF cabozantinib 0.8425783 0.9801808 0.84258 NA NA
GNB1 docetaxel 0.8431622 0.9801808 0.84316 NA NA
SETBP1 vismodegib 0.8431988 0.9801808 0.84320 NA NA
JAK1 afatinib 0.8434616 0.9801808 0.84346 NA NA
JAK3 afatinib 0.8440781 0.9805385 0.84408 NA NA
WT1 ruxolitinib 0.8454506 0.9809780 0.84545 NA NA
STAG2 ponatinib 0.8454770 0.9809780 0.84548 NA NA
EML4 dasatinib 0.8456669 0.9809780 0.84567 NA NA
EML4 crizotinib 0.8463945 0.9809780 0.84639 NA NA
UGT1A1 rucaparib 0.8467310 0.9809780 0.84673 NA NA
MAP2K1 ponatinib 0.8469335 0.9809780 0.84693 NA NA
ERBB2 cabozantinib 0.8477762 0.9809780 0.84778 NA NA
FGFR1 ponatinib 0.8480615 0.9809780 0.84806 NA NA
IDH1 sunitinib 0.8485350 0.9809780 0.84854 NA NA
MYCN sunitinib 0.8485350 0.9809780 0.84854 NA NA
DDIT3 vismodegib 0.8486410 0.9809780 0.84864 NA NA
PAX8 temozolomide 0.8489663 0.9809780 0.84897 NA NA
SF3B1 ponatinib 0.8491288 0.9809780 0.84913 NA NA
EZH2 dabrafenib 0.8492920 0.9809780 0.84929 NA NA
DNMT3A gefitinib 0.8493836 0.9809780 0.84938 NA NA
STAG2 cabozantinib 0.8502250 0.9809780 0.85023 NA NA
TPMT pazopanib 0.8511938 0.9809780 0.85119 NA NA
PRPF8 erlotinib 0.8511983 0.9809780 0.85120 NA NA
KRAS crizotinib 0.8512775 0.9809780 0.85128 NA NA
MET cabozantinib 0.8512783 0.9809780 0.85128 NA NA
CRLF2 vismodegib 0.8514764 0.9809780 0.85148 NA NA
GATA3 rucaparib 0.8515819 0.9809780 0.85158 NA NA
JAK2 imatinib 0.8521878 0.9809780 0.85219 NA NA
JAK2 ruxolitinib 0.8523436 0.9809780 0.85234 NA NA
FGFR3 bosutinib monohydrate 0.8529747 0.9809780 0.85297 NA NA
GNAS gefitinib 0.8530306 0.9809780 0.85303 NA NA
CSF3R bosutinib monohydrate 0.8534255 0.9809780 0.85343 NA NA
BTK dabrafenib 0.8535378 0.9809780 0.85354 NA NA
UGT1A1 docetaxel 0.8542969 0.9809780 0.85430 NA NA
STAT3 palbociclib 0.8543064 0.9809780 0.85431 NA NA
MET dasatinib 0.8543593 0.9809780 0.85436 NA NA
CXCR4 crizotinib 0.8549228 0.9809780 0.85492 NA NA
JAK1 nilotinib 0.8549572 0.9809780 0.85496 NA NA
WT1 nilotinib 0.8552599 0.9809780 0.85526 NA NA
MYD88 ponatinib 0.8552763 0.9809780 0.85528 NA NA
FGFR2 vismodegib 0.8556611 0.9809780 0.85566 NA NA
ERBB4 ponatinib 0.8558847 0.9809780 0.85588 NA NA
CRLF2 gefitinib 0.8566401 0.9814103 0.85664 NA NA
EML4 gefitinib 0.8568799 0.9814103 0.85688 NA NA
FLCN afatinib 0.8573994 0.9815915 0.85740 NA NA
CTNNB1 rucaparib 0.8579792 0.9815915 0.85798 NA NA
BTK nilotinib 0.8582165 0.9815915 0.85822 NA NA
CSF3R lapatinib 0.8590618 0.9815915 0.85906 NA NA
SMO gefitinib 0.8593636 0.9815915 0.85936 NA NA
RUNX1 afatinib 0.8597949 0.9815915 0.85979 NA NA
CRLF2 afatinib 0.8603484 0.9815915 0.86035 NA NA
GNAQ afatinib 0.8603484 0.9815915 0.86035 NA NA
DPYD erlotinib 0.8604995 0.9815915 0.86050 NA NA
GNB1 erlotinib 0.8604995 0.9815915 0.86050 NA NA
PRPF40B dabrafenib 0.8607282 0.9815915 0.86073 NA NA
PRPF40B tretinoin 0.8614099 0.9815915 0.86141 NA NA
PAX5 rucaparib 0.8616629 0.9815915 0.86166 NA NA
IDH1 cabozantinib 0.8618554 0.9815915 0.86186 NA NA
CD79B crizotinib 0.8619832 0.9815915 0.86198 NA NA
GNAQ crizotinib 0.8619832 0.9815915 0.86198 NA NA
IL7R dasatinib 0.8625869 0.9816246 0.86259 NA NA
ROS1 palbociclib 0.8627523 0.9816246 0.86275 NA NA
CRLF2 sunitinib 0.8629395 0.9816246 0.86294 NA NA
GNB1 vismodegib 0.8642884 0.9823372 0.86429 NA NA
PRPF40B alectinib 0.8649658 0.9823372 0.86497 NA NA
ERBB4 erlotinib 0.8652272 0.9823372 0.86523 NA NA
RIT1 trametinib 0.8654388 0.9823372 0.86544 NA NA
NPM1 afatinib 0.8655570 0.9823372 0.86556 NA NA
UGT1A1 vismodegib 0.8657073 0.9823372 0.86571 NA NA
NCOA2 docetaxel 0.8662319 0.9823372 0.86623 NA NA
PHF6 belinostat 0.8666835 0.9823372 0.86668 NA NA
PTPN11 gefitinib 0.8668680 0.9823372 0.86687 NA NA
RIT1 dabrafenib 0.8669500 0.9823372 0.86695 NA NA
SF3B1 crizotinib 0.8672340 0.9823372 0.86723 NA NA
NPM1 trametinib 0.8672776 0.9823372 0.86728 NA NA
SETD2 temozolomide 0.8680092 0.9824100 0.86801 NA NA
G6PD dasatinib 0.8682306 0.9824100 0.86823 NA NA
KIT crizotinib 0.8686498 0.9824100 0.86865 NA NA
U2AF1 lapatinib 0.8687945 0.9824100 0.86879 NA NA
SMO belinostat 0.8688884 0.9824100 0.86889 NA NA
ESR1 ponatinib 0.8695576 0.9824849 0.86956 NA NA
FLT3 bosutinib monohydrate 0.8695733 0.9824849 0.86957 NA NA
PDCD1 ponatinib 0.8703157 0.9829740 0.87032 NA NA
GATA1 docetaxel 0.8709152 0.9833014 0.87092 NA NA
GATA3 nilotinib 0.8715965 0.9834739 0.87160 NA NA
PDCD1 gefitinib 0.8718376 0.9834739 0.87184 NA NA
KMT2A ponatinib 0.8723076 0.9834739 0.87231 NA NA
CXCR4 alectinib 0.8726340 0.9834739 0.87263 NA NA
SRSF2 temozolomide 0.8729244 0.9834739 0.87292 NA NA
CDC73 alectinib 0.8729260 0.9834739 0.87293 NA NA
DNMT3A lapatinib 0.8744953 0.9848926 0.87450 NA NA
FGFR3 tretinoin 0.8758961 0.9861205 0.87590 NA NA
CDK4 imatinib 0.8774107 0.9874757 0.87741 NA NA
NOTCH1 nilotinib 0.8779959 0.9877843 0.87800 NA NA
STAG2 lapatinib 0.8799391 0.9884322 0.87994 NA NA
CXCR4 erlotinib 0.8802653 0.9884322 0.88027 NA NA
ERBB3 vismodegib 0.8804120 0.9884322 0.88041 NA NA
WHSC1 afatinib 0.8804758 0.9884322 0.88048 NA NA
RUNX1 imatinib 0.8807874 0.9884322 0.88079 NA NA
TPMT ponatinib 0.8811769 0.9884322 0.88118 NA NA
AR afatinib 0.8812495 0.9884322 0.88125 NA NA
PAX5 dabrafenib 0.8814339 0.9884322 0.88143 NA NA
PIK3CA bosutinib monohydrate 0.8814447 0.9884322 0.88144 NA NA
ERBB4 docetaxel 0.8816840 0.9884322 0.88168 NA NA
AKT3 belinostat 0.8831307 0.9889058 0.88313 NA NA
MAP2K1 midostaurin 0.8831837 0.9889058 0.88318 NA NA
MYCN dabrafenib 0.8835841 0.9889058 0.88358 NA NA
FGFR1 tretinoin 0.8836154 0.9889058 0.88362 NA NA
WT1 lapatinib 0.8836758 0.9889058 0.88368 NA NA
AR palbociclib 0.8839747 0.9889058 0.88397 NA NA
JAK2 midostaurin 0.8847197 0.9893907 0.88472 NA NA
DNAJB1 docetaxel 0.8861532 0.9904803 0.88615 NA NA
FGFR1 cabozantinib 0.8867029 0.9904803 0.88670 NA NA
EML4 erlotinib 0.8868224 0.9904803 0.88682 NA NA
BRCA2 ruxolitinib 0.8869414 0.9904803 0.88694 NA NA
TET2 erlotinib 0.8873786 0.9906202 0.88738 NA NA
JAK1 lapatinib 0.8879653 0.9909269 0.88797 NA NA
PHF6 nilotinib 0.8886369 0.9912900 0.88864 NA NA
ATM bosutinib monohydrate 0.8890563 0.9912900 0.88906 NA NA
MYD88 bosutinib monohydrate 0.8892270 0.9912900 0.88923 NA NA
PIGA bosutinib monohydrate 0.8899516 0.9917496 0.88995 NA NA
JAK2 pazopanib 0.8907594 0.9918063 0.89076 NA NA
CTLA4 palbociclib 0.8909703 0.9918063 0.89097 NA NA
BTK lapatinib 0.8911322 0.9918063 0.89113 NA NA
SMO vismodegib 0.8914996 0.9918063 0.89150 NA NA
SETD2 gefitinib 0.8920610 0.9918063 0.89206 NA NA
FGFR3 alectinib 0.8924433 0.9918063 0.89244 NA NA
FGFR2 dasatinib 0.8929128 0.9918063 0.89291 NA NA
SETD2 ruxolitinib 0.8932673 0.9918063 0.89327 NA NA
STAT3 trametinib 0.8932780 0.9918063 0.89328 NA NA
FGFR2 sunitinib 0.8937255 0.9918063 0.89373 NA NA
CRLF2 midostaurin 0.8940790 0.9918063 0.89408 NA NA
IDH1 afatinib 0.8943509 0.9918063 0.89435 NA NA
MYCN bosutinib monohydrate 0.8946713 0.9918063 0.89467 NA NA
IKZF1 afatinib 0.8947795 0.9918063 0.89478 NA NA
PRPF40B palbociclib 0.8948596 0.9918063 0.89486 NA NA
CDK4 ruxolitinib 0.8949990 0.9918063 0.89500 NA NA
BRCA2 cabozantinib 0.8957636 0.9919816 0.89576 NA NA
BCOR alectinib 0.8960633 0.9919816 0.89606 NA NA
EML4 belinostat 0.8965070 0.9919816 0.89651 NA NA
ROS1 ruxolitinib 0.8966205 0.9919816 0.89662 NA NA
PML trametinib 0.8969530 0.9919816 0.89695 NA NA
GNAS docetaxel 0.8970312 0.9919816 0.89703 NA NA
MPL pazopanib 0.8975234 0.9921804 0.89752 NA NA
RPL10 temozolomide 0.8989536 0.9921877 0.89895 NA NA
MGMT dasatinib 0.8989855 0.9921877 0.89899 NA NA
SSX1 trametinib 0.8990463 0.9921877 0.89905 NA NA
AR bosutinib monohydrate 0.8991314 0.9921877 0.89913 NA NA
PTEN lapatinib 0.8993258 0.9921877 0.89933 NA NA
CEBPA ponatinib 0.8994044 0.9921877 0.89940 NA NA
CDK4 nilotinib 0.8998193 0.9922569 0.89982 NA NA
SMC1A palbociclib 0.9001829 0.9922569 0.90018 NA NA
GATA3 dabrafenib 0.9004044 0.9922569 0.90040 NA NA
ALK bosutinib monohydrate 0.9008561 0.9923487 0.90086 NA NA
BRAF afatinib 0.9011510 0.9923487 0.90115 NA NA
NT5C2 pazopanib 0.9014251 0.9923487 0.90143 NA NA
AKT2 imatinib 0.9023418 0.9930137 0.90234 NA NA
SETD2 erlotinib 0.9034192 0.9938550 0.90342 NA NA
ROS1 crizotinib 0.9055984 0.9956992 0.90560 NA NA
CRLF2 alectinib 0.9059455 0.9956992 0.90595 NA NA
TSC1 belinostat 0.9061702 0.9956992 0.90617 NA NA
GATA2 nilotinib 0.9063496 0.9956992 0.90635 NA NA
ERBB3 docetaxel 0.9076995 0.9964206 0.90770 NA NA
NOTCH1 pazopanib 0.9077883 0.9964206 0.90779 NA NA
WT1 bosutinib monohydrate 0.9087099 0.9964206 0.90871 NA NA
CDKN2A lapatinib 0.9091620 0.9964206 0.90916 NA NA
AKT1 temozolomide 0.9094399 0.9964206 0.90944 NA NA
U2AF1 vismodegib 0.9095190 0.9964206 0.90952 NA NA
ASXL1 vismodegib 0.9095642 0.9964206 0.90956 NA NA
CDKN2A crizotinib 0.9099113 0.9964206 0.90991 NA NA
GATA1 ponatinib 0.9103985 0.9964206 0.91040 NA NA
SMC3 ponatinib 0.9106175 0.9964206 0.91062 NA NA
CYP19A1 dabrafenib 0.9107211 0.9964206 0.91072 NA NA
EML4 lapatinib 0.9110932 0.9964206 0.91109 NA NA
CTLA4 rucaparib 0.9111547 0.9964206 0.91115 NA NA
PRPF8 alectinib 0.9120043 0.9964206 0.91200 NA NA
BCOR afatinib 0.9121893 0.9964206 0.91219 NA NA
CREBBP cabozantinib 0.9124382 0.9964206 0.91244 NA NA
ESR1 erlotinib 0.9133687 0.9964206 0.91337 NA NA
JAK1 crizotinib 0.9136622 0.9964206 0.91366 NA NA
BRCA1 lapatinib 0.9142372 0.9964206 0.91424 NA NA
EGFR cabozantinib 0.9149328 0.9964206 0.91493 NA NA
BRCA2 sunitinib 0.9151190 0.9964206 0.91512 NA NA
FGFR1 dabrafenib 0.9151888 0.9964206 0.91519 NA NA
NOTCH2 imatinib 0.9152305 0.9964206 0.91523 NA NA
CD79B ruxolitinib 0.9154477 0.9964206 0.91545 NA NA
TSC1 gefitinib 0.9156569 0.9964206 0.91566 NA NA
ROS1 imatinib 0.9157097 0.9964206 0.91571 NA NA
ERBB2 ponatinib 0.9158815 0.9964206 0.91588 NA NA
NT5C2 afatinib 0.9160346 0.9964206 0.91603 NA NA
BRAF dasatinib 0.9161548 0.9964206 0.91615 NA NA
KMT2A temozolomide 0.9165748 0.9964206 0.91657 NA NA
BRCA2 dabrafenib 0.9168207 0.9964206 0.91682 NA NA
CBLB erlotinib 0.9170458 0.9964206 0.91705 NA NA
G6PD temozolomide 0.9184100 0.9975617 0.91841 NA NA
PRPF40B docetaxel 0.9187358 0.9975743 0.91874 NA NA
TP53 crizotinib 0.9190956 0.9976239 0.91910 NA NA
IL7R docetaxel 0.9196203 0.9978525 0.91962 NA NA
JAK2 lapatinib 0.9210478 0.9978589 0.92105 NA NA
PIK3CA ponatinib 0.9215126 0.9978589 0.92151 NA NA
NPM1 sunitinib 0.9216497 0.9978589 0.92165 NA NA
PRPF8 ponatinib 0.9216621 0.9978589 0.92166 NA NA
EED palbociclib 0.9217317 0.9978589 0.92173 NA NA
JAK1 docetaxel 0.9217329 0.9978589 0.92173 NA NA
EGFR erlotinib 0.9218958 0.9978589 0.92190 NA NA
ATM belinostat 0.9231828 0.9978589 0.92318 NA NA
SETBP1 imatinib 0.9231968 0.9978589 0.92320 NA NA
PRPF8 lapatinib 0.9234249 0.9978589 0.92342 NA NA
CBL cabozantinib 0.9234314 0.9978589 0.92343 NA NA
NOTCH1 ponatinib 0.9235323 0.9978589 0.92353 NA NA
CREBBP vismodegib 0.9238700 0.9978589 0.92387 NA NA
SH2B3 alectinib 0.9243076 0.9978589 0.92431 NA NA
ROS1 lapatinib 0.9246091 0.9978589 0.92461 NA NA
PDGFRA ruxolitinib 0.9248089 0.9978589 0.92481 NA NA
HRAS bosutinib monohydrate 0.9249674 0.9978589 0.92497 NA NA
KIT ponatinib 0.9257639 0.9978685 0.92576 NA NA
SF3B1 temozolomide 0.9259576 0.9978685 0.92596 NA NA
CTNNB1 belinostat 0.9260261 0.9978685 0.92603 NA NA
UGT1A1 cabozantinib 0.9262331 0.9978685 0.92623 NA NA
PTCH1 erlotinib 0.9275623 0.9980324 0.92756 NA NA
CALR belinostat 0.9275787 0.9980324 0.92758 NA NA
CTCF pazopanib 0.9276294 0.9980324 0.92763 NA NA
AR pazopanib 0.9277609 0.9980324 0.92776 NA NA
MYD88 gefitinib 0.9283678 0.9980324 0.92837 NA NA
GNAQ ponatinib 0.9286811 0.9980324 0.92868 NA NA
FBXW7 belinostat 0.9290017 0.9980324 0.92900 NA NA
CREBBP alectinib 0.9297312 0.9980324 0.92973 NA NA
TSC1 afatinib 0.9300086 0.9980324 0.93001 NA NA
KIT belinostat 0.9303304 0.9980324 0.93033 NA NA
EML4 temozolomide 0.9305234 0.9980324 0.93052 NA NA
RET erlotinib 0.9307227 0.9980324 0.93072 NA NA
MAP2K2 ponatinib 0.9308325 0.9980324 0.93083 NA NA
EML4 ruxolitinib 0.9311316 0.9980324 0.93113 NA NA
PTEN imatinib 0.9311434 0.9980324 0.93114 NA NA
MYCN alectinib 0.9314131 0.9980324 0.93141 NA NA
MYD88 lapatinib 0.9323054 0.9983599 0.93231 NA NA
BTK temozolomide 0.9330073 0.9983599 0.93301 NA NA
SF3B1 cabozantinib 0.9332356 0.9983599 0.93324 NA NA
IDH1 crizotinib 0.9332905 0.9983599 0.93329 NA NA
MYCN crizotinib 0.9332905 0.9983599 0.93329 NA NA
ATM cabozantinib 0.9341291 0.9983602 0.93413 NA NA
STAT3 pazopanib 0.9342701 0.9983602 0.93427 NA NA
IDH1 alectinib 0.9344033 0.9983602 0.93440 NA NA
SETBP1 rucaparib 0.9349068 0.9983602 0.93491 NA NA
CALR bosutinib monohydrate 0.9357151 0.9983602 0.93572 NA NA
NOTCH2 trametinib 0.9359551 0.9983602 0.93596 NA NA
PAX5 belinostat 0.9366113 0.9983602 0.93661 NA NA
CDK6 belinostat 0.9369710 0.9983602 0.93697 NA NA
CALR alectinib 0.9372021 0.9983602 0.93720 NA NA
MDM2 belinostat 0.9372150 0.9983602 0.93721 NA NA
VHL trametinib 0.9375075 0.9983602 0.93751 NA NA
AKT3 vismodegib 0.9378898 0.9983602 0.93789 NA NA
PDCD1 tretinoin 0.9379623 0.9983602 0.93796 NA NA
BTK crizotinib 0.9381895 0.9983602 0.93819 NA NA
PAX8 imatinib 0.9384184 0.9983602 0.93842 NA NA
IL7R lapatinib 0.9384466 0.9983602 0.93845 NA NA
NCOA2 alectinib 0.9388572 0.9983602 0.93886 NA NA
GATA2 dabrafenib 0.9389490 0.9983602 0.93895 NA NA
FLCN rucaparib 0.9396675 0.9983602 0.93967 NA NA
MGMT vismodegib 0.9400649 0.9983602 0.94006 NA NA
FBXW7 trametinib 0.9408952 0.9983602 0.94090 NA NA
SSX1 vismodegib 0.9409047 0.9983602 0.94090 NA NA
RPL10 belinostat 0.9410297 0.9983602 0.94103 NA NA
STAG2 dasatinib 0.9411192 0.9983602 0.94112 NA NA
CDK4 bosutinib monohydrate 0.9416541 0.9983602 0.94165 NA NA
BRCA2 trametinib 0.9421624 0.9983602 0.94216 NA NA
ASXL1 sunitinib 0.9421871 0.9983602 0.94219 NA NA
FBXW7 bosutinib monohydrate 0.9426717 0.9983602 0.94267 NA NA
CSF3R belinostat 0.9429053 0.9983602 0.94291 NA NA
PIGA dabrafenib 0.9436553 0.9983602 0.94366 NA NA
IDH2 alectinib 0.9437117 0.9983602 0.94371 NA NA
FANCL temozolomide 0.9438077 0.9983602 0.94381 NA NA
IDH2 palbociclib 0.9443484 0.9983602 0.94435 NA NA
CSF3R alectinib 0.9447105 0.9983602 0.94471 NA NA
EGFR vismodegib 0.9448114 0.9983602 0.94481 NA NA
ERBB4 rucaparib 0.9452339 0.9983602 0.94523 NA NA
TP53 bosutinib monohydrate 0.9456282 0.9983602 0.94563 NA NA
RAD21 belinostat 0.9463328 0.9983602 0.94633 NA NA
CXCR4 imatinib 0.9466483 0.9983602 0.94665 NA NA
MPL imatinib 0.9466483 0.9983602 0.94665 NA NA
XPO1 midostaurin 0.9469456 0.9983602 0.94695 NA NA
IDH2 midostaurin 0.9477169 0.9983602 0.94772 NA NA
RIT1 midostaurin 0.9477169 0.9983602 0.94772 NA NA
CRLF2 rucaparib 0.9477501 0.9983602 0.94775 NA NA
ABL1 vismodegib 0.9494533 0.9983602 0.94945 NA NA
CBLB sunitinib 0.9503016 0.9983602 0.95030 NA NA
ESR1 afatinib 0.9503087 0.9983602 0.95031 NA NA
CSF3R temozolomide 0.9503618 0.9983602 0.95036 NA NA
SETD2 docetaxel 0.9506315 0.9983602 0.95063 NA NA
SRSF2 alectinib 0.9507839 0.9983602 0.95078 NA NA
PRPF8 ruxolitinib 0.9509706 0.9983602 0.95097 NA NA
BCOR lapatinib 0.9510755 0.9983602 0.95108 NA NA
FGFR2 afatinib 0.9511520 0.9983602 0.95115 NA NA
ROS1 dasatinib 0.9512458 0.9983602 0.95125 NA NA
AKT2 dasatinib 0.9512631 0.9983602 0.95126 NA NA
UGT1A1 ruxolitinib 0.9514154 0.9983602 0.95142 NA NA
ETV6 belinostat 0.9514347 0.9983602 0.95143 NA NA
FANCL belinostat 0.9517795 0.9983602 0.95178 NA NA
PML afatinib 0.9518372 0.9983602 0.95184 NA NA
BRCA1 temozolomide 0.9526259 0.9988577 0.95263 NA NA
ETV6 erlotinib 0.9532871 0.9989432 0.95329 NA NA
SMO trametinib 0.9533365 0.9989432 0.95334 NA NA
MAP2K2 tretinoin 0.9548035 0.9990974 0.95480 NA NA
CRLF2 ponatinib 0.9548438 0.9990974 0.95484 NA NA
NCOA2 bosutinib monohydrate 0.9552949 0.9990974 0.95529 NA NA
CD79B vismodegib 0.9553598 0.9990974 0.95536 NA NA
PRPF8 trametinib 0.9559535 0.9990974 0.95595 NA NA
ALK ponatinib 0.9561548 0.9990974 0.95615 NA NA
SSX1 nilotinib 0.9563025 0.9990974 0.95630 NA NA
RET midostaurin 0.9563247 0.9990974 0.95632 NA NA
IKZF1 rucaparib 0.9570156 0.9990974 0.95702 NA NA
GATA1 tretinoin 0.9577014 0.9990974 0.95770 NA NA
BRAF lapatinib 0.9579143 0.9990974 0.95791 NA NA
SMC1A belinostat 0.9581409 0.9990974 0.95814 NA NA
RET pazopanib 0.9581510 0.9990974 0.95815 NA NA
SETD2 crizotinib 0.9583372 0.9990974 0.95834 NA NA
BCORL1 rucaparib 0.9589124 0.9990974 0.95891 NA NA
PAX5 palbociclib 0.9597535 0.9990974 0.95975 NA NA
TET2 sunitinib 0.9597590 0.9990974 0.95976 NA NA
CXCR4 pazopanib 0.9598696 0.9990974 0.95987 NA NA
PDGFRA dasatinib 0.9608776 0.9990974 0.96088 NA NA
NRAS bosutinib monohydrate 0.9617340 0.9990974 0.96173 NA NA
SMC1A ponatinib 0.9617697 0.9990974 0.96177 NA NA
GNAQ cabozantinib 0.9622409 0.9990974 0.96224 NA NA
ASXL1 nilotinib 0.9628343 0.9990974 0.96283 NA NA
MPL ruxolitinib 0.9628412 0.9990974 0.96284 NA NA
BTK belinostat 0.9628687 0.9990974 0.96287 NA NA
XPO1 lapatinib 0.9630445 0.9990974 0.96304 NA NA
FBXW7 palbociclib 0.9637857 0.9990974 0.96379 NA NA
ALK imatinib 0.9639389 0.9990974 0.96394 NA NA
FLCN temozolomide 0.9645329 0.9990974 0.96453 NA NA
CRLF2 ruxolitinib 0.9649859 0.9990974 0.96499 NA NA
SF1 rucaparib 0.9651374 0.9990974 0.96514 NA NA
GATA3 erlotinib 0.9653874 0.9990974 0.96539 NA NA
SF1 vismodegib 0.9658373 0.9990974 0.96584 NA NA
SH2B3 gefitinib 0.9659820 0.9990974 0.96598 NA NA
NT5C2 lapatinib 0.9661181 0.9990974 0.96612 NA NA
GNAS belinostat 0.9662777 0.9990974 0.96628 NA NA
BCORL1 vismodegib 0.9665371 0.9990974 0.96654 NA NA
NCOA2 gefitinib 0.9667617 0.9990974 0.96676 NA NA
BCOR ponatinib 0.9670462 0.9990974 0.96705 NA NA
CRLF2 imatinib 0.9673747 0.9990974 0.96737 NA NA
DPYD nilotinib 0.9678380 0.9990974 0.96784 NA NA
G6PD lapatinib 0.9681165 0.9990974 0.96812 NA NA
AR dabrafenib 0.9681760 0.9990974 0.96818 NA NA
IDH2 dabrafenib 0.9684328 0.9990974 0.96843 NA NA
PAX5 trametinib 0.9686829 0.9990974 0.96868 NA NA
KIT alectinib 0.9692528 0.9990974 0.96925 NA NA
AKT1 docetaxel 0.9695144 0.9990974 0.96951 NA NA
AKT2 ruxolitinib 0.9698154 0.9990974 0.96982 NA NA
RUNX1 bosutinib monohydrate 0.9702483 0.9990974 0.97025 NA NA
SMC3 docetaxel 0.9711363 0.9990974 0.97114 NA NA
AKT2 trametinib 0.9713673 0.9990974 0.97137 NA NA
MDM2 erlotinib 0.9714442 0.9990974 0.97144 NA NA
DNMT3A belinostat 0.9723117 0.9990974 0.97231 NA NA
CYP19A1 vismodegib 0.9723531 0.9990974 0.97235 NA NA
MDM2 dasatinib 0.9723856 0.9990974 0.97239 NA NA
GATA2 ruxolitinib 0.9725671 0.9990974 0.97257 NA NA
PDCD1 rucaparib 0.9729859 0.9990974 0.97299 NA NA
FANCL dabrafenib 0.9732873 0.9990974 0.97329 NA NA
BRCA2 vismodegib 0.9733078 0.9990974 0.97331 NA NA
SMC3 dabrafenib 0.9734466 0.9990974 0.97345 NA NA
AR ponatinib 0.9737798 0.9990974 0.97378 NA NA
PML lapatinib 0.9738117 0.9990974 0.97381 NA NA
VHL cabozantinib 0.9746401 0.9990974 0.97464 NA NA
AKT2 dabrafenib 0.9755082 0.9990974 0.97551 NA NA
WHSC1 alectinib 0.9757368 0.9990974 0.97574 NA NA
PIGA vismodegib 0.9761297 0.9990974 0.97613 NA NA
ERBB4 pazopanib 0.9762228 0.9990974 0.97622 NA NA
U2AF1 belinostat 0.9762326 0.9990974 0.97623 NA NA
NRAS alectinib 0.9762797 0.9990974 0.97628 NA NA
BCOR palbociclib 0.9763682 0.9990974 0.97637 NA NA
PAX5 ponatinib 0.9765095 0.9990974 0.97651 NA NA
CRLF2 bosutinib monohydrate 0.9769377 0.9990974 0.97694 NA NA
ATM ruxolitinib 0.9769582 0.9990974 0.97696 NA NA
CBLB afatinib 0.9770926 0.9990974 0.97709 NA NA
FLT3 vismodegib 0.9773105 0.9990974 0.97731 NA NA
MYD88 dabrafenib 0.9773916 0.9990974 0.97739 NA NA
PDGFRB trametinib 0.9784811 0.9991250 0.97848 NA NA
RIT1 temozolomide 0.9786787 0.9991250 0.97868 NA NA
PAX8 midostaurin 0.9789346 0.9991250 0.97893 NA NA
SMC1A ruxolitinib 0.9791385 0.9991250 0.97914 NA NA
FBXW7 imatinib 0.9792390 0.9991250 0.97924 NA NA
PRPF40B vismodegib 0.9793061 0.9991250 0.97931 NA NA
AKT2 palbociclib 0.9809077 0.9999163 0.98091 NA NA
SH2B3 rucaparib 0.9811815 0.9999163 0.98118 NA NA
CTCF palbociclib 0.9812762 0.9999163 0.98128 NA NA
AKT3 gefitinib 0.9813410 0.9999163 0.98134 NA NA
EED belinostat 0.9816838 0.9999447 0.98168 NA NA
ATM gefitinib 0.9830253 0.9999651 0.98303 NA NA
PIK3CA trametinib 0.9832477 0.9999651 0.98325 NA NA
KRAS alectinib 0.9838427 0.9999651 0.98384 NA NA
PAX8 trametinib 0.9839656 0.9999651 0.98397 NA NA
CTNNB1 vismodegib 0.9841264 0.9999651 0.98413 NA NA
TPMT bosutinib monohydrate 0.9847665 0.9999651 0.98477 NA NA
ETV6 sunitinib 0.9847737 0.9999651 0.98477 NA NA
ESR1 alectinib 0.9851623 0.9999651 0.98516 NA NA
CTCF sunitinib 0.9858463 0.9999651 0.98585 NA NA
WHSC1 dabrafenib 0.9865696 0.9999651 0.98657 NA NA
PIK3CA lapatinib 0.9866347 0.9999651 0.98663 NA NA
MYCN nilotinib 0.9867686 0.9999651 0.98677 NA NA
KMT2A tretinoin 0.9867957 0.9999651 0.98680 NA NA
PIK3CA imatinib 0.9871324 0.9999651 0.98713 NA NA
KMT2A gefitinib 0.9877838 0.9999651 0.98778 NA NA
PTCH1 lapatinib 0.9878187 0.9999651 0.98782 NA NA
PTCH1 imatinib 0.9882665 0.9999651 0.98827 NA NA
JAK2 ponatinib 0.9882767 0.9999651 0.98828 NA NA
FGFR2 dabrafenib 0.9883831 0.9999651 0.98838 NA NA
GNB1 midostaurin 0.9890693 0.9999651 0.98907 NA NA
BCOR crizotinib 0.9890817 0.9999651 0.98908 NA NA
ATM palbociclib 0.9892046 0.9999651 0.98920 NA NA
FGFR2 bosutinib monohydrate 0.9892432 0.9999651 0.98924 NA NA
DNAJB1 vismodegib 0.9892602 0.9999651 0.98926 NA NA
SH2B3 belinostat 0.9899582 1.0000000 0.98996 NA NA
FGFR2 tretinoin 0.9899834 1.0000000 0.98998 NA NA
CBLB imatinib 0.9907752 1.0000000 0.99078 NA NA
ALK nilotinib 0.9911966 1.0000000 0.99120 NA NA
ETV6 afatinib 0.9917220 1.0000000 0.99172 NA NA
PTEN dasatinib 0.9918913 1.0000000 0.99189 NA NA
EED ponatinib 0.9938213 1.0000000 0.99382 NA NA
FBXW7 crizotinib 0.9940455 1.0000000 0.99405 NA NA
JAK1 imatinib 0.9944990 1.0000000 0.99450 NA NA
FLCN bosutinib monohydrate 0.9945924 1.0000000 0.99459 NA NA
MGMT ruxolitinib 0.9946721 1.0000000 0.99467 NA NA
PHF6 crizotinib 0.9948625 1.0000000 0.99486 NA NA
ROS1 dabrafenib 0.9949724 1.0000000 0.99497 NA NA
DDIT3 bosutinib monohydrate 0.9949740 1.0000000 0.99497 NA NA
SMO alectinib 0.9950076 1.0000000 0.99501 NA NA
CDKN2A midostaurin 0.9959831 1.0000000 0.99598 NA NA
GATA3 bosutinib monohydrate 0.9960502 1.0000000 0.99605 NA NA
ZRSR2 dasatinib 0.9962487 1.0000000 0.99625 NA NA
PAX8 sunitinib 0.9962773 1.0000000 0.99628 NA NA
WT1 rucaparib 0.9967317 1.0000000 0.99673 NA NA
ABL1 tretinoin 0.9968006 1.0000000 0.99680 NA NA
AKT1 ponatinib 0.9972326 1.0000000 0.99723 NA NA
DNAJB1 rucaparib 0.9975452 1.0000000 0.99755 NA NA
CREBBP rucaparib 0.9980993 1.0000000 0.99810 NA NA
PHF6 palbociclib 0.9984149 1.0000000 0.99841 NA NA
JAK2 bosutinib monohydrate 0.9984574 1.0000000 0.99846 NA NA
DNMT3A pazopanib 0.9995159 1.0000000 0.99952 NA NA
BCORL1 erlotinib 1.0000000 1.0000000 1.00000 NA NA
EGF rucaparib 1.0000000 1.0000000 1.00000 NA NA
FGFR3 nilotinib 1.0000000 1.0000000 1.00000 NA NA
IDH1 belinostat 1.0000000 1.0000000 1.00000 NA NA
MGMT imatinib 1.0000000 1.0000000 1.00000 NA NA
NOTCH2 docetaxel 1.0000000 1.0000000 1.00000 NA NA
PHF6 afatinib 1.0000000 1.0000000 1.00000 NA NA 
gdsc_signif_lvlA_ByDrug <- readRDS("./data_munging/rds/gdsc_signif_lvlA_ByDrug.rds")
gdsc_signif_lvlA_ByDrug_all <- rbindlist(gdsc_signif_lvlA_ByDrug, use.names = TRUE)
gdsc_signif_lvlA_ByDrug_all <- gdsc_signif_lvlA_ByDrug_all[order(gdsc_signif_lvlA_ByDrug_all$p.adj),]

knitr::kable(gdsc_signif_lvlA_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: by-drug Wilcoxon test results for Level A point mutations, (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
GDSC: by-drug Wilcoxon test results for Level A point mutations, (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
RET temozolomide 0.0026631 0.3009325 0.0027 ** NA
ETV6 pazopanib 0.0196244 0.8210078 0.020
NA
BTK pazopanib 0.0337522 0.8210078 0.034
NA
ABL1 pazopanib 0.0388839 0.8210078 0.039
NA
TSC2 pazopanib 0.0449679 0.8210078 0.045
NA
IDH1 pazopanib 0.0570399 0.8210078 0.057 NA NA
NOTCH2 pazopanib 0.0575408 0.8210078 0.058 NA NA
FGFR2 pazopanib 0.0677256 0.8210078 0.068 NA NA
IKZF1 pazopanib 0.0687048 0.8210078 0.069 NA NA
BRAF pazopanib 0.0807087 0.8210078 0.081 NA NA
PTCH1 pazopanib 0.0811235 0.8210078 0.081 NA NA
MGMT pazopanib 0.0813611 0.8210078 0.081 NA NA
BCORL1 temozolomide 0.0233805 0.8262472 0.0234
NA
EML4 temozolomide 0.0335702 0.8262472 0.0336
NA
TP53 temozolomide 0.0377257 0.8262472 0.0377
NA
JAK1 temozolomide 0.0390480 0.8262472 0.0390
NA
SMO temozolomide 0.0482552 0.8262472 0.0483
NA
DNMT3A temozolomide 0.0742813 0.8262472 0.0743 NA NA
AKT3 temozolomide 0.0813611 0.8262472 0.0814 NA NA
ETV6 temozolomide 0.1051925 0.8262472 0.1052 NA NA
ATM temozolomide 0.1077751 0.8262472 0.1078 NA NA
CD79B temozolomide 0.1116118 0.8262472 0.1116 NA NA
TET2 temozolomide 0.1149749 0.8262472 0.1150 NA NA
PIK3CA temozolomide 0.1161003 0.8262472 0.1161 NA NA
MGMT temozolomide 0.1360371 0.8262472 0.1360 NA NA
GNAS temozolomide 0.1549743 0.8262472 0.1550 NA NA
FBXW7 temozolomide 0.1582595 0.8262472 0.1583 NA NA
SETBP1 temozolomide 0.1661958 0.8262472 0.1662 NA NA
MAP2K1 temozolomide 0.1752442 0.8262472 0.1752 NA NA
HRAS temozolomide 0.1752442 0.8262472 0.1752 NA NA
FLT3 temozolomide 0.1796050 0.8262472 0.1796 NA NA
CSF3R temozolomide 0.1984493 0.8262472 0.1984 NA NA
JAK2 temozolomide 0.2048709 0.8262472 0.2049 NA NA
STAT3 temozolomide 0.2048939 0.8262472 0.2049 NA NA
PTEN temozolomide 0.2253663 0.8262472 0.2254 NA NA
AR temozolomide 0.2296941 0.8262472 0.2297 NA NA
FGFR2 temozolomide 0.2353333 0.8262472 0.2353 NA NA
PAX8 temozolomide 0.2409547 0.8262472 0.2410 NA NA
NPM1 temozolomide 0.2471600 0.8262472 0.2472 NA NA
PAX5 temozolomide 0.2544506 0.8262472 0.2545 NA NA
GNB1 temozolomide 0.2544506 0.8262472 0.2545 NA NA
PDGFRB temozolomide 0.2683073 0.8262472 0.2683 NA NA
ERBB2 temozolomide 0.2704472 0.8262472 0.2704 NA NA
ESR1 temozolomide 0.2718987 0.8262472 0.2719 NA NA
FGFR3 temozolomide 0.2744311 0.8262472 0.2744 NA NA
FGFR1 temozolomide 0.2787627 0.8262472 0.2788 NA NA
IL7R temozolomide 0.2863206 0.8262472 0.2863 NA NA
CTNNB1 temozolomide 0.2867038 0.8262472 0.2867 NA NA
ABL1 temozolomide 0.2903468 0.8262472 0.2903 NA NA
ERBB4 temozolomide 0.2936694 0.8262472 0.2937 NA NA
AKT1 temozolomide 0.2938258 0.8262472 0.2938 NA NA
VHL temozolomide 0.3035890 0.8262472 0.3036 NA NA
JAK3 temozolomide 0.3073142 0.8262472 0.3073 NA NA
CDK4 temozolomide 0.3144127 0.8262472 0.3144 NA NA
NOTCH2 temozolomide 0.3218228 0.8264994 0.3218 NA NA
AKT2 temozolomide 0.3329216 0.8307573 0.3329 NA NA
MET temozolomide 0.3405518 0.8307573 0.3406 NA NA
TSC1 temozolomide 0.3498070 0.8307573 0.3498 NA NA
IDH2 temozolomide 0.3710934 0.8307573 0.3711 NA NA
CDK6 temozolomide 0.3710934 0.8307573 0.3711 NA NA
SMC3 temozolomide 0.3821206 0.8307573 0.3821 NA NA
IDH1 temozolomide 0.3827331 0.8307573 0.3827 NA NA
STAG2 temozolomide 0.3855466 0.8307573 0.3855 NA NA
KMT2A temozolomide 0.3975435 0.8307573 0.3975 NA NA
KRAS temozolomide 0.3977064 0.8307573 0.3977 NA NA
ERBB3 temozolomide 0.4088092 0.8307573 0.4088 NA NA
BCOR temozolomide 0.4117027 0.8307573 0.4117 NA NA
MPL temozolomide 0.4291953 0.8460011 0.4292 NA NA
DNAJB1 temozolomide 0.4532547 0.8460011 0.4533 NA NA
CBLB temozolomide 0.4595426 0.8460011 0.4595 NA NA
ASXL1 temozolomide 0.4623354 0.8460011 0.4623 NA NA
RAD21 temozolomide 0.4681599 0.8460011 0.4682 NA NA
TSC2 temozolomide 0.4844292 0.8460011 0.4844 NA NA
RUNX1 temozolomide 0.4862343 0.8460011 0.4862 NA NA
CALR temozolomide 0.4874533 0.8460011 0.4875 NA NA
CRLF2 temozolomide 0.4874533 0.8460011 0.4875 NA NA
SF1 temozolomide 0.4941245 0.8460011 0.4941 NA NA
FBXW7 vismodegib 0.0495864 0.8577626 0.050
NA
JAK1 vismodegib 0.0507543 0.8577626 0.051 NA NA
EML4 vismodegib 0.0509160 0.8577626 0.051 NA NA
SETBP1 vismodegib 0.0598774 0.8577626 0.060 NA NA
NCOA2 vismodegib 0.1107652 0.8577626 0.111 NA NA
FLT3 vismodegib 0.1180896 0.8577626 0.118 NA NA
CSF3R vismodegib 0.1375639 0.8577626 0.138 NA NA
RET vismodegib 0.1389052 0.8577626 0.139 NA NA
SF3B1 vismodegib 0.1390453 0.8577626 0.139 NA NA
ABL1 vismodegib 0.1478561 0.8577626 0.148 NA NA
DDIT3 vismodegib 0.1489147 0.8577626 0.149 NA NA
GATA3 vismodegib 0.1696541 0.8577626 0.170 NA NA
XPO1 vismodegib 0.1714602 0.8577626 0.171 NA NA
DNMT3A vismodegib 0.1730732 0.8577626 0.173 NA NA
IDH1 vismodegib 0.1904303 0.8577626 0.190 NA NA
MPL vismodegib 0.1904303 0.8577626 0.190 NA NA
TSC1 vismodegib 0.2023268 0.8577626 0.202 NA NA
CBL vismodegib 0.2112995 0.8577626 0.211 NA NA
BTK vismodegib 0.2193026 0.8577626 0.219 NA NA
IL7R vismodegib 0.2313504 0.8577626 0.231 NA NA
MYD88 vismodegib 0.2415666 0.8577626 0.242 NA NA
JAK2 vismodegib 0.2433046 0.8577626 0.243 NA NA
JAK3 vismodegib 0.2473671 0.8577626 0.247 NA NA
NOTCH1 vismodegib 0.2519151 0.8577626 0.252 NA NA
ATM vismodegib 0.2602462 0.8577626 0.260 NA NA
STAG2 vismodegib 0.2635525 0.8577626 0.264 NA NA
TSC2 vismodegib 0.2771857 0.8577626 0.277 NA NA
EZH2 vismodegib 0.2780757 0.8577626 0.278 NA NA
HRAS vismodegib 0.2888444 0.8577626 0.289 NA NA
BRAF vismodegib 0.2890849 0.8577626 0.289 NA NA
BCOR vismodegib 0.2900957 0.8577626 0.290 NA NA
ETV6 vismodegib 0.2986177 0.8577626 0.299 NA NA
WHSC1 vismodegib 0.3166393 0.8577626 0.317 NA NA
DPYD vismodegib 0.3193494 0.8577626 0.319 NA NA
GATA2 vismodegib 0.3298592 0.8577626 0.330 NA NA
CTCF vismodegib 0.3322673 0.8577626 0.332 NA NA
GNA11 vismodegib 0.3329216 0.8577626 0.333 NA NA
CREBBP vismodegib 0.3398218 0.8577626 0.340 NA NA
CBLB vismodegib 0.3525421 0.8577626 0.353 NA NA
ESR1 vismodegib 0.3552259 0.8577626 0.355 NA NA
ZRSR2 vismodegib 0.3593968 0.8577626 0.359 NA NA
ERBB3 vismodegib 0.3635665 0.8577626 0.364 NA NA
KRAS vismodegib 0.3653976 0.8577626 0.365 NA NA
SSX1 vismodegib 0.3710934 0.8577626 0.371 NA NA
PIK3CA vismodegib 0.3748571 0.8577626 0.375 NA NA
UGT1A1 vismodegib 0.3777807 0.8577626 0.378 NA NA
TP53 vismodegib 0.3780932 0.8577626 0.378 NA NA
NPM1 vismodegib 0.3864762 0.8577626 0.386 NA NA
G6PD vismodegib 0.3864762 0.8577626 0.386 NA NA
SRSF2 vismodegib 0.3864762 0.8577626 0.386 NA NA
FGFR1 vismodegib 0.3941071 0.8577626 0.394 NA NA
ROS1 temozolomide 0.5230400 0.8613352 0.5230 NA NA
NCOA2 temozolomide 0.5316674 0.8613352 0.5317 NA NA
NRAS temozolomide 0.5337384 0.8613352 0.5337 NA NA
EGFR temozolomide 0.5377225 0.8613352 0.5377 NA NA
ZRSR2 temozolomide 0.5411929 0.8613352 0.5412 NA NA
XPO1 temozolomide 0.5522142 0.8666695 0.5522 NA NA
EGF temozolomide 0.5620826 0.8700731 0.5621 NA NA
PDGFRB ponatinib 0.0365333 0.8778615 0.037
NA
CBLB ponatinib 0.0644577 0.8778615 0.064 NA NA
CTNNB1 ponatinib 0.0684090 0.8778615 0.068 NA NA
SMO ponatinib 0.0757091 0.8778615 0.076 NA NA
STAG2 ponatinib 0.0828374 0.8778615 0.083 NA NA
NRAS ponatinib 0.0838740 0.8778615 0.084 NA NA
CALR ponatinib 0.1051925 0.8778615 0.105 NA NA
TSC1 ponatinib 0.1063243 0.8778615 0.106 NA NA
JAK1 ponatinib 0.1097093 0.8778615 0.110 NA NA
BRCA2 ponatinib 0.1303619 0.8778615 0.130 NA NA
CDKN2A ponatinib 0.1356578 0.8778615 0.136 NA NA
ATM ponatinib 0.1391840 0.8778615 0.139 NA NA
CTCF ponatinib 0.1484736 0.8778615 0.148 NA NA
BTK ponatinib 0.1488365 0.8778615 0.149 NA NA
GNA11 ponatinib 0.1489147 0.8778615 0.149 NA NA
NOTCH1 ponatinib 0.1539242 0.8778615 0.154 NA NA
BCOR ponatinib 0.1623426 0.8778615 0.162 NA NA
EZH2 ponatinib 0.1630631 0.8778615 0.163 NA NA
PAX8 ponatinib 0.1658066 0.8778615 0.166 NA NA
GNB1 ponatinib 0.1714602 0.8778615 0.171 NA NA
PTEN ponatinib 0.1742555 0.8778615 0.174 NA NA
SMC3 ponatinib 0.1927903 0.8778615 0.193 NA NA
ERBB3 ponatinib 0.1942557 0.8778615 0.194 NA NA
RAD21 ponatinib 0.1966114 0.8778615 0.197 NA NA
CSF3R ponatinib 0.2027302 0.8778615 0.203 NA NA
WHSC1 ponatinib 0.2056252 0.8778615 0.206 NA NA
BRCA1 vismodegib 0.4258825 0.8988081 0.426 NA NA
RAD21 vismodegib 0.4291606 0.8988081 0.429 NA NA
NPM1 pazopanib 0.1051925 0.8993847 0.105 NA NA
SH2B3 pazopanib 0.1206908 0.8993847 0.121 NA NA
FLT3 pazopanib 0.1253511 0.8993847 0.125 NA NA
PDGFRB pazopanib 0.1334699 0.8993847 0.133 NA NA
SETD2 pazopanib 0.1382390 0.8993847 0.138 NA NA
MET pazopanib 0.1422064 0.8993847 0.142 NA NA
IL7R pazopanib 0.1551316 0.8993847 0.155 NA NA
PRPF8 pazopanib 0.1613294 0.8993847 0.161 NA NA
MAP2K1 pazopanib 0.1637344 0.8993847 0.164 NA NA
KMT2A pazopanib 0.1883664 0.8993847 0.188 NA NA
KIT pazopanib 0.1912977 0.8993847 0.191 NA NA
NCOA2 pazopanib 0.1916946 0.8993847 0.192 NA NA
SETBP1 pazopanib 0.1985377 0.8993847 0.199 NA NA
CREBBP pazopanib 0.2112688 0.8993847 0.211 NA NA
EGF pazopanib 0.2313504 0.8993847 0.231 NA NA
SF1 pazopanib 0.2330380 0.8993847 0.233 NA NA
NT5C2 pazopanib 0.2452781 0.8993847 0.245 NA NA
CALR pazopanib 0.2471600 0.8993847 0.247 NA NA
CRLF2 pazopanib 0.2471600 0.8993847 0.247 NA NA
JAK1 pazopanib 0.2532459 0.8993847 0.253 NA NA
CBLB pazopanib 0.2672575 0.8993847 0.267 NA NA
NRAS pazopanib 0.2685846 0.8993847 0.269 NA NA
FGFR3 pazopanib 0.2782314 0.8993847 0.278 NA NA
FGFR1 pazopanib 0.3052255 0.8993847 0.305 NA NA
SF3B1 pazopanib 0.3138562 0.8993847 0.314 NA NA
EML4 pazopanib 0.3140923 0.8993847 0.314 NA NA
STAG2 pazopanib 0.3153025 0.8993847 0.315 NA NA
DPYD pazopanib 0.3194547 0.8993847 0.319 NA NA
AKT1 pazopanib 0.3251627 0.8993847 0.325 NA NA
AR pazopanib 0.3322052 0.8993847 0.332 NA NA
GATA2 pazopanib 0.3413493 0.9021375 0.341 NA NA
JAK2 ponatinib 0.2216120 0.9110714 0.222 NA NA
SETD2 ponatinib 0.2301306 0.9123036 0.230 NA NA
DPYD temozolomide 0.6112381 0.9145880 0.6112 NA NA
NOTCH1 temozolomide 0.6177566 0.9145880 0.6178 NA NA
KIT temozolomide 0.6238962 0.9145880 0.6239 NA NA
PML temozolomide 0.6332644 0.9145880 0.6333 NA NA
BRAF temozolomide 0.6362263 0.9145880 0.6362 NA NA
WHSC1 temozolomide 0.6394022 0.9145880 0.6394 NA NA
BRCA1 temozolomide 0.6566664 0.9186432 0.6567 NA NA
CBL temozolomide 0.6625206 0.9186432 0.6625 NA NA
WT1 temozolomide 0.6761033 0.9186432 0.6761 NA NA
BRCA2 temozolomide 0.6821937 0.9186432 0.6822 NA NA
CDKN2A temozolomide 0.6884095 0.9186432 0.6884 NA NA
CTLA4 temozolomide 0.6985354 0.9186432 0.6985 NA NA
PDGFRA temozolomide 0.7070567 0.9186432 0.7071 NA NA
CTCF temozolomide 0.7092180 0.9186432 0.7092 NA NA
PRPF40B temozolomide 0.7154036 0.9186432 0.7154 NA NA
PAX8 cabozantinib 0.0142140 0.9193630 0.014
NA
GNB1 cabozantinib 0.0226545 0.9193630 0.023
NA
RAD21 cabozantinib 0.0480900 0.9193630 0.048
NA
ROS1 cabozantinib 0.0613353 0.9193630 0.061 NA NA
BRCA2 cabozantinib 0.0613414 0.9193630 0.061 NA NA
ZRSR2 cabozantinib 0.0667981 0.9193630 0.067 NA NA
NRAS cabozantinib 0.0722114 0.9193630 0.072 NA NA
STAG2 cabozantinib 0.0745316 0.9193630 0.075 NA NA
SMC3 cabozantinib 0.0802844 0.9193630 0.080 NA NA
NCOA2 cabozantinib 0.0848219 0.9193630 0.085 NA NA
CBLB cabozantinib 0.1083194 0.9193630 0.108 NA NA
PTEN cabozantinib 0.1101615 0.9193630 0.110 NA NA
CREBBP cabozantinib 0.1124400 0.9193630 0.112 NA NA
EGF cabozantinib 0.1211415 0.9193630 0.121 NA NA
EML4 cabozantinib 0.1459236 0.9193630 0.146 NA NA
DDIT3 cabozantinib 0.1489147 0.9193630 0.149 NA NA
SRSF2 cabozantinib 0.1489147 0.9193630 0.149 NA NA
SF3B1 cabozantinib 0.1507509 0.9193630 0.151 NA NA
AKT3 cabozantinib 0.1752442 0.9193630 0.175 NA NA
SETD2 cabozantinib 0.1798550 0.9193630 0.180 NA NA
ESR1 cabozantinib 0.1845726 0.9193630 0.185 NA NA
TP53 cabozantinib 0.2098332 0.9193630 0.210 NA NA
DNAJB1 cabozantinib 0.2112995 0.9193630 0.211 NA NA
SH2B3 cabozantinib 0.2353333 0.9193630 0.235 NA NA
DPYD cabozantinib 0.2389642 0.9193630 0.239 NA NA
PDGFB cabozantinib 0.2415666 0.9193630 0.242 NA NA
CTLA4 cabozantinib 0.2452781 0.9193630 0.245 NA NA
JAK1 cabozantinib 0.2532459 0.9193630 0.253 NA NA
FGFR2 cabozantinib 0.2842147 0.9193630 0.284 NA NA
SETBP1 cabozantinib 0.2937080 0.9193630 0.294 NA NA
MPL cabozantinib 0.2962699 0.9193630 0.296 NA NA
BCOR cabozantinib 0.3058167 0.9193630 0.306 NA NA
CTNNB1 cabozantinib 0.3072865 0.9193630 0.307 NA NA
SMC1A cabozantinib 0.3123214 0.9193630 0.312 NA NA
CDK4 cabozantinib 0.3144127 0.9193630 0.314 NA NA
ATM cabozantinib 0.3326874 0.9193630 0.333 NA NA
AKT2 cabozantinib 0.3329216 0.9193630 0.333 NA NA
IDH2 cabozantinib 0.3710934 0.9193630 0.371 NA NA
SSX1 cabozantinib 0.3710934 0.9193630 0.371 NA NA
CDK6 cabozantinib 0.3710934 0.9193630 0.371 NA NA
TET2 cabozantinib 0.3791145 0.9193630 0.379 NA NA
CD79B cabozantinib 0.3827331 0.9193630 0.383 NA NA
PTCH1 cabozantinib 0.3978820 0.9193630 0.398 NA NA
ERBB2 cabozantinib 0.4095468 0.9193630 0.410 NA NA
AR cabozantinib 0.4146659 0.9193630 0.415 NA NA
PRPF8 cabozantinib 0.4235074 0.9193630 0.424 NA NA
PRPF40B cabozantinib 0.4352640 0.9193630 0.435 NA NA
PDGFRA cabozantinib 0.4385081 0.9193630 0.439 NA NA
TSC1 cabozantinib 0.4442892 0.9193630 0.444 NA NA
BTK cabozantinib 0.4446962 0.9193630 0.445 NA NA
STAT3 cabozantinib 0.4468728 0.9193630 0.447 NA NA
ERBB3 cabozantinib 0.4553522 0.9193630 0.455 NA NA
AKT1 cabozantinib 0.4605582 0.9193630 0.461 NA NA
KIT cabozantinib 0.4611737 0.9193630 0.461 NA NA
MET cabozantinib 0.4699300 0.9193630 0.470 NA NA
PML cabozantinib 0.4766160 0.9193630 0.477 NA NA
CALR cabozantinib 0.4874533 0.9193630 0.487 NA NA
BCORL1 cabozantinib 0.5061157 0.9193630 0.506 NA NA
XPO1 cabozantinib 0.5083316 0.9193630 0.508 NA NA
FGFR1 cabozantinib 0.5160638 0.9193630 0.516 NA NA
ERBB4 cabozantinib 0.5301982 0.9193630 0.530 NA NA
EZH2 cabozantinib 0.5499800 0.9193630 0.550 NA NA
MGMT cabozantinib 0.5509850 0.9193630 0.551 NA NA
ABL1 cabozantinib 0.5517639 0.9193630 0.552 NA NA
SMO cabozantinib 0.5538183 0.9193630 0.554 NA NA
GATA1 cabozantinib 0.5565355 0.9193630 0.557 NA NA
FBXW7 cabozantinib 0.5579963 0.9193630 0.558 NA NA
MYD88 cabozantinib 0.5581846 0.9193630 0.558 NA NA
WT1 trametinib 0.0367139 0.9200442 0.037
NA
CTNNB1 trametinib 0.0385722 0.9200442 0.039
NA
PTEN trametinib 0.0473677 0.9200442 0.047
NA
SF3B1 trametinib 0.0479663 0.9200442 0.048
NA
GATA2 trametinib 0.0481324 0.9200442 0.048
NA
GATA3 trametinib 0.0488519 0.9200442 0.049
NA
SSX1 pazopanib 0.3710934 0.9221928 0.371 NA NA
CDK6 pazopanib 0.3710934 0.9221928 0.371 NA NA
GATA1 pazopanib 0.3777807 0.9221928 0.378 NA NA
DDIT3 pazopanib 0.3864762 0.9221928 0.386 NA NA
MYCN pazopanib 0.3912673 0.9221928 0.391 NA NA
WHSC1 pazopanib 0.3987861 0.9221928 0.399 NA NA
WHSC1 cabozantinib 0.5739514 0.9316312 0.574 NA NA
VHL vismodegib 0.4533555 0.9318974 0.453 NA NA
BRCA2 dabrafenib 0.0114366 0.9357211 0.011
NA
DNMT3A dabrafenib 0.0231070 0.9357211 0.023
NA
JAK1 dabrafenib 0.0259429 0.9357211 0.026
NA
EML4 dabrafenib 0.0572376 0.9357211 0.057 NA NA
KRAS dabrafenib 0.0723200 0.9357211 0.072 NA NA
XPO1 dabrafenib 0.0827310 0.9357211 0.083 NA NA
PRPF8 dabrafenib 0.0891198 0.9357211 0.089 NA NA
SMO dabrafenib 0.1008557 0.9357211 0.101 NA NA
EZH2 dabrafenib 0.1061785 0.9357211 0.106 NA NA
BCORL1 dabrafenib 0.1251117 0.9357211 0.125 NA NA
MET dabrafenib 0.1272789 0.9357211 0.127 NA NA
BRAF dabrafenib 0.1452299 0.9357211 0.145 NA NA
CTCF dabrafenib 0.1564698 0.9357211 0.156 NA NA
AR dabrafenib 0.1750566 0.9357211 0.175 NA NA
CBL dabrafenib 0.1904303 0.9357211 0.190 NA NA
STAG2 dabrafenib 0.1930591 0.9357211 0.193 NA NA
SMC1A dabrafenib 0.2159249 0.9357211 0.216 NA NA
FLT3 dabrafenib 0.2244778 0.9357211 0.224 NA NA
JAK3 dabrafenib 0.2336459 0.9357211 0.234 NA NA
PDGFB dabrafenib 0.2415666 0.9357211 0.242 NA NA
NT5C2 dabrafenib 0.2471600 0.9357211 0.247 NA NA
G6PD dabrafenib 0.2471600 0.9357211 0.247 NA NA
GNB1 dabrafenib 0.2544506 0.9357211 0.254 NA NA
PML dabrafenib 0.2570320 0.9357211 0.257 NA NA
RUNX1 dabrafenib 0.2962699 0.9357211 0.296 NA NA
NCOA2 dabrafenib 0.3123214 0.9357211 0.312 NA NA
GATA1 dabrafenib 0.3129507 0.9357211 0.313 NA NA
TP53 dabrafenib 0.3320151 0.9357211 0.332 NA NA
AKT3 dabrafenib 0.3329216 0.9357211 0.333 NA NA
FGFR1 dabrafenib 0.3532136 0.9357211 0.353 NA NA
CBLB dabrafenib 0.3552259 0.9357211 0.355 NA NA
PAX8 dabrafenib 0.3661566 0.9357211 0.366 NA NA
DDIT3 dabrafenib 0.3710934 0.9357211 0.371 NA NA
CDK6 dabrafenib 0.3710934 0.9357211 0.371 NA NA
NOTCH1 dabrafenib 0.3712443 0.9357211 0.371 NA NA
CD79B dabrafenib 0.3767591 0.9357211 0.377 NA NA
MAP2K1 dabrafenib 0.3827331 0.9357211 0.383 NA NA
CDKN2A dabrafenib 0.3873600 0.9357211 0.387 NA NA
TSC2 dabrafenib 0.3911237 0.9357211 0.391 NA NA
WT1 dabrafenib 0.3912673 0.9357211 0.391 NA NA
KMT2A dabrafenib 0.4027293 0.9357211 0.403 NA NA
BRCA1 dabrafenib 0.4045764 0.9357211 0.405 NA NA
GNAS dabrafenib 0.4077637 0.9357211 0.408 NA NA
PTCH1 dabrafenib 0.4156390 0.9357211 0.416 NA NA
EGF dabrafenib 0.4277675 0.9357211 0.428 NA NA
CDK4 dabrafenib 0.4344457 0.9357211 0.434 NA NA
EGFR dabrafenib 0.4410555 0.9357211 0.441 NA NA
GATA3 dabrafenib 0.4466947 0.9357211 0.447 NA NA
IDH1 dabrafenib 0.4532547 0.9357211 0.453 NA NA
TET2 dabrafenib 0.4573905 0.9357211 0.457 NA NA
ROS1 dabrafenib 0.4708634 0.9357211 0.471 NA NA
PIK3CA dabrafenib 0.4725223 0.9357211 0.473 NA NA
SETD2 dabrafenib 0.4832976 0.9357211 0.483 NA NA
NOTCH2 dabrafenib 0.4843451 0.9357211 0.484 NA NA
NPM1 dabrafenib 0.4874533 0.9357211 0.487 NA NA
CRLF2 dabrafenib 0.4874533 0.9357211 0.487 NA NA
HRAS dabrafenib 0.4874533 0.9357211 0.487 NA NA
DPYD dabrafenib 0.5253897 0.9357211 0.525 NA NA
ABL1 dabrafenib 0.5259894 0.9357211 0.526 NA NA
JAK2 dabrafenib 0.5261475 0.9357211 0.526 NA NA
MYCN dabrafenib 0.5402914 0.9357211 0.540 NA NA
ZRSR2 dabrafenib 0.5411929 0.9357211 0.541 NA NA
PRPF40B dabrafenib 0.5433991 0.9357211 0.543 NA NA
CTNNB1 dabrafenib 0.5453763 0.9357211 0.545 NA NA
MGMT dabrafenib 0.5509850 0.9357211 0.551 NA NA
MYD88 dabrafenib 0.5581846 0.9357211 0.558 NA NA
CXCR4 dabrafenib 0.5581846 0.9357211 0.558 NA NA
ERBB2 dabrafenib 0.5630888 0.9357211 0.563 NA NA
CTNNB1 pazopanib 0.4348101 0.9378484 0.435 NA NA
EZH2 pazopanib 0.4397098 0.9378484 0.440 NA NA
CXCR4 pazopanib 0.4532547 0.9378484 0.453 NA NA
DNAJB1 pazopanib 0.4532547 0.9378484 0.453 NA NA
PAX8 pazopanib 0.4555451 0.9378484 0.456 NA NA
BCOR pazopanib 0.4847907 0.9378484 0.485 NA NA
NOTCH1 pazopanib 0.5211245 0.9378484 0.521 NA NA
JAK3 pazopanib 0.5282274 0.9378484 0.528 NA NA
TP53 pazopanib 0.5347727 0.9378484 0.535 NA NA
VHL pazopanib 0.5393680 0.9378484 0.539 NA NA
CTLA4 pazopanib 0.5402914 0.9378484 0.540 NA NA
CDKN2A pazopanib 0.5408422 0.9378484 0.541 NA NA
ATM pazopanib 0.5485326 0.9378484 0.549 NA NA
TSC1 pazopanib 0.5518589 0.9378484 0.552 NA NA
PDGFB pazopanib 0.5581846 0.9378484 0.558 NA NA
PML pazopanib 0.5601226 0.9378484 0.560 NA NA
CBL pazopanib 0.5612758 0.9378484 0.561 NA NA
SMC3 pazopanib 0.5712256 0.9378484 0.571 NA NA
CTCF pazopanib 0.5781234 0.9378484 0.578 NA NA
BRCA2 pazopanib 0.5801065 0.9378484 0.580 NA NA
GNAS pazopanib 0.5829868 0.9378484 0.583 NA NA
BRCA2 ruxolitinib 0.0613414 0.9382521 0.061 NA NA
ERBB4 ruxolitinib 0.1006551 0.9382521 0.101 NA NA
CALR ruxolitinib 0.1051925 0.9382521 0.105 NA NA
IDH1 ruxolitinib 0.1073465 0.9382521 0.107 NA NA
PDGFRA ruxolitinib 0.1085452 0.9382521 0.109 NA NA
PDGFRB ruxolitinib 0.1098305 0.9382521 0.110 NA NA
PAX5 ruxolitinib 0.1106121 0.9382521 0.111 NA NA
AR ruxolitinib 0.1179481 0.9382521 0.118 NA NA
MGMT ruxolitinib 0.1360371 0.9382521 0.136 NA NA
RET ruxolitinib 0.1392493 0.9382521 0.139 NA NA
DDIT3 ruxolitinib 0.1489147 0.9382521 0.149 NA NA
ATM ruxolitinib 0.1501605 0.9382521 0.150 NA NA
CBLB ruxolitinib 0.1507856 0.9382521 0.151 NA NA
STAT3 ruxolitinib 0.1507856 0.9382521 0.151 NA NA
TET2 ruxolitinib 0.1512811 0.9382521 0.151 NA NA
FBXW7 ruxolitinib 0.1548213 0.9382521 0.155 NA NA
AKT3 ruxolitinib 0.1752442 0.9382521 0.175 NA NA
CSF3R ruxolitinib 0.1824224 0.9382521 0.182 NA NA
ERBB3 ruxolitinib 0.2134248 0.9382521 0.213 NA NA
EGFR ruxolitinib 0.2223767 0.9382521 0.222 NA NA
DNMT3A ruxolitinib 0.2236189 0.9382521 0.224 NA NA
PAX8 ruxolitinib 0.2409547 0.9382521 0.241 NA NA
MYD88 ruxolitinib 0.2415666 0.9382521 0.242 NA NA
SF1 ruxolitinib 0.2452781 0.9382521 0.245 NA NA
CTLA4 ruxolitinib 0.2452781 0.9382521 0.245 NA NA
GNB1 ruxolitinib 0.2544506 0.9382521 0.254 NA NA
WHSC1 ruxolitinib 0.2608080 0.9382521 0.261 NA NA
DPYD ruxolitinib 0.2653106 0.9382521 0.265 NA NA
NRAS ruxolitinib 0.2685846 0.9382521 0.269 NA NA
BCORL1 ruxolitinib 0.2847911 0.9382521 0.285 NA NA
HRAS ruxolitinib 0.2888444 0.9382521 0.289 NA NA
XPO1 ruxolitinib 0.2986177 0.9382521 0.299 NA NA
KMT2A ruxolitinib 0.2990397 0.9382521 0.299 NA NA
JAK1 ruxolitinib 0.3372059 0.9382521 0.337 NA NA
FGFR2 ruxolitinib 0.3447042 0.9382521 0.345 NA NA
GNAS ruxolitinib 0.3454721 0.9382521 0.345 NA NA
PTEN ruxolitinib 0.3490434 0.9382521 0.349 NA NA
STAG2 ruxolitinib 0.3502376 0.9382521 0.350 NA NA
BCOR ruxolitinib 0.3595380 0.9382521 0.360 NA NA
IDH2 ruxolitinib 0.3710934 0.9382521 0.371 NA NA
SSX1 ruxolitinib 0.3710934 0.9382521 0.371 NA NA
CDK6 ruxolitinib 0.3710934 0.9382521 0.371 NA NA
ABL1 ruxolitinib 0.3814787 0.9382521 0.381 NA NA
CD79B ruxolitinib 0.3827331 0.9382521 0.383 NA NA
FGFR1 ruxolitinib 0.4037318 0.9382521 0.404 NA NA
CREBBP ruxolitinib 0.4069927 0.9382521 0.407 NA NA
CTCF ruxolitinib 0.4119913 0.9382521 0.412 NA NA
NCOA2 ruxolitinib 0.4334219 0.9382521 0.433 NA NA
SMC3 ruxolitinib 0.4403309 0.9382521 0.440 NA NA
TSC1 ruxolitinib 0.4442892 0.9382521 0.444 NA NA
CTNNB1 ruxolitinib 0.4658564 0.9382521 0.466 NA NA
MET ruxolitinib 0.4699300 0.9382521 0.470 NA NA
SMC1A ruxolitinib 0.4704864 0.9382521 0.470 NA NA
ESR1 ruxolitinib 0.4749585 0.9382521 0.475 NA NA
GNA11 ruxolitinib 0.4874533 0.9382521 0.487 NA NA
SMO ruxolitinib 0.4897397 0.9382521 0.490 NA NA
BRCA1 ruxolitinib 0.5004224 0.9382521 0.500 NA NA
SH2B3 ruxolitinib 0.5228167 0.9382521 0.523 NA NA
ERBB2 ruxolitinib 0.5308130 0.9382521 0.531 NA NA
BRAF ruxolitinib 0.5317794 0.9382521 0.532 NA NA
ZRSR2 ruxolitinib 0.5411929 0.9382521 0.541 NA NA
IKZF1 ruxolitinib 0.5439933 0.9382521 0.544 NA NA
PML ruxolitinib 0.5443086 0.9382521 0.544 NA NA
ALK ruxolitinib 0.5538155 0.9382521 0.554 NA NA
PDGFB ruxolitinib 0.5581846 0.9382521 0.558 NA NA
AKT2 ruxolitinib 0.5612758 0.9382521 0.561 NA NA
CBL ruxolitinib 0.5612758 0.9382521 0.561 NA NA
ALK pazopanib 0.5931401 0.9405507 0.593 NA NA
CSF3R dabrafenib 0.5815410 0.9454318 0.582 NA NA
ETV6 dabrafenib 0.5891545 0.9454318 0.589 NA NA
GATA2 dabrafenib 0.5940323 0.9454318 0.594 NA NA
AKT3 vismodegib 0.4874533 0.9510339 0.487 NA NA
NT5C2 vismodegib 0.4874533 0.9510339 0.487 NA NA
ERBB4 vismodegib 0.4883688 0.9510339 0.488 NA NA
RUNX1 pazopanib 0.6352563 0.9535338 0.635 NA NA
GNB1 pazopanib 0.6485034 0.9535338 0.649 NA NA
TET2 pazopanib 0.6521684 0.9535338 0.652 NA NA
CD79B pazopanib 0.6625206 0.9535338 0.663 NA NA
SMC1A pazopanib 0.6650055 0.9535338 0.665 NA NA
WT1 pazopanib 0.6678058 0.9535338 0.668 NA NA
PRPF40B pazopanib 0.6717534 0.9535338 0.672 NA NA
DNMT3A pazopanib 0.6849970 0.9535338 0.685 NA NA
GATA3 pazopanib 0.6871276 0.9535338 0.687 NA NA
SMO pazopanib 0.6930652 0.9535338 0.693 NA NA
BRCA1 pazopanib 0.6982607 0.9535338 0.698 NA NA
KRAS pazopanib 0.7123892 0.9535338 0.712 NA NA
MYD88 pazopanib 0.7236736 0.9535338 0.724 NA NA
CDK4 pazopanib 0.7373721 0.9535338 0.737 NA NA
ZRSR2 pazopanib 0.7599815 0.9535338 0.760 NA NA
PDGFRA pazopanib 0.7621399 0.9535338 0.762 NA NA
SRSF2 pazopanib 0.7728300 0.9535338 0.773 NA NA
ASXL1 pazopanib 0.7749850 0.9535338 0.775 NA NA
UGT1A1 pazopanib 0.7758198 0.9535338 0.776 NA NA
RET pazopanib 0.7921474 0.9535338 0.792 NA NA
BCORL1 pazopanib 0.7947269 0.9535338 0.795 NA NA
ERBB3 pazopanib 0.7983763 0.9535338 0.798 NA NA
CSF3R pazopanib 0.7989067 0.9535338 0.799 NA NA
ALK tretinoin 0.0086111 0.9558271 0.0086 ** NA
GATA2 tretinoin 0.0347556 0.9576410 0.0348
NA
FLT3 tretinoin 0.0487764 0.9576410 0.0488
NA
JAK1 tretinoin 0.0507543 0.9576410 0.0508 NA NA
EML4 tretinoin 0.0509160 0.9576410 0.0509 NA NA
ZRSR2 tretinoin 0.0667981 0.9576410 0.0668 NA NA
XPO1 tretinoin 0.0682475 0.9576410 0.0682 NA NA
CSF3R tretinoin 0.0770999 0.9576410 0.0771 NA NA
KRAS tretinoin 0.0834354 0.9576410 0.0834 NA NA
NOTCH2 tretinoin 0.0862740 0.9576410 0.0863 NA NA
G6PD pazopanib 0.8169613 0.9577635 0.817 NA NA
PAX5 pazopanib 0.8197075 0.9577635 0.820 NA NA
EGF ruxolitinib 0.5823194 0.9591143 0.582 NA NA
AKT3 pazopanib 0.8464506 0.9686187 0.846 NA NA
AKT2 pazopanib 0.8464506 0.9686187 0.846 NA NA
PRPF8 temozolomide 0.7640767 0.9701199 0.7641 NA NA
JAK3 cabozantinib 0.6138599 0.9701347 0.614 NA NA
BRCA1 cabozantinib 0.6468079 0.9701347 0.647 NA NA
FLT3 cabozantinib 0.6957712 0.9701347 0.696 NA NA
CTCF cabozantinib 0.7092180 0.9701347 0.709 NA NA
CDKN2A cabozantinib 0.7136757 0.9701347 0.714 NA NA
GATA2 cabozantinib 0.7143930 0.9701347 0.714 NA NA
IKZF1 cabozantinib 0.7158048 0.9701347 0.716 NA NA
KRAS cabozantinib 0.7218134 0.9701347 0.722 NA NA
ETV6 cabozantinib 0.7236736 0.9701347 0.724 NA NA
HRAS cabozantinib 0.7236736 0.9701347 0.724 NA NA
FGFR3 cabozantinib 0.7554200 0.9701347 0.755 NA NA
NT5C2 cabozantinib 0.7728300 0.9701347 0.773 NA NA
WT1 cabozantinib 0.7747957 0.9701347 0.775 NA NA
ASXL1 cabozantinib 0.7749850 0.9701347 0.775 NA NA
CSF3R cabozantinib 0.7897258 0.9701347 0.790 NA NA
UGT1A1 cabozantinib 0.7982151 0.9701347 0.798 NA NA
BRAF cabozantinib 0.7996672 0.9701347 0.800 NA NA
CXCR4 cabozantinib 0.8025873 0.9701347 0.803 NA NA
TSC2 cabozantinib 0.8083330 0.9701347 0.808 NA NA
NPM1 cabozantinib 0.8169613 0.9701347 0.817 NA NA
CRLF2 cabozantinib 0.8169613 0.9701347 0.817 NA NA
GNA11 cabozantinib 0.8169613 0.9701347 0.817 NA NA
PAX5 cabozantinib 0.8197075 0.9701347 0.820 NA NA
ALK cabozantinib 0.8285166 0.9701347 0.829 NA NA
RET cabozantinib 0.8437136 0.9701347 0.844 NA NA
NOTCH1 cabozantinib 0.8445723 0.9701347 0.845 NA NA
CBL cabozantinib 0.8464506 0.9701347 0.846 NA NA
NOTCH2 cabozantinib 0.8541769 0.9701347 0.854 NA NA
G6PD cabozantinib 0.8596838 0.9701347 0.860 NA NA
IL7R cabozantinib 0.8668153 0.9701347 0.867 NA NA
RUNX1 cabozantinib 0.8743671 0.9701347 0.874 NA NA
IDH1 cabozantinib 0.8836175 0.9701347 0.884 NA NA
KMT2A cabozantinib 0.8924536 0.9701347 0.892 NA NA
SF1 cabozantinib 0.8972790 0.9701347 0.897 NA NA
GNAS cabozantinib 0.9008394 0.9701347 0.901 NA NA
TET2 vismodegib 0.5099301 0.9734628 0.510 NA NA
CTLA4 vismodegib 0.5402914 0.9734628 0.540 NA NA
BRCA2 vismodegib 0.5419273 0.9734628 0.542 NA NA
CDKN2A vismodegib 0.5474939 0.9734628 0.547 NA NA
PDGFB vismodegib 0.5581846 0.9734628 0.558 NA NA
AKT2 vismodegib 0.5581846 0.9734628 0.558 NA NA
MAP2K1 vismodegib 0.5612758 0.9734628 0.561 NA NA
PRPF40B vismodegib 0.5703340 0.9739551 0.570 NA NA
JAK2 pazopanib 0.8613880 0.9756538 0.861 NA NA
DNMT3A nilotinib 0.0163480 0.9770019 0.016
NA
NOTCH2 nilotinib 0.0476544 0.9770019 0.048
NA
CTCF nilotinib 0.0622469 0.9770019 0.062 NA NA
JAK1 nilotinib 0.0624074 0.9770019 0.062 NA NA
KMT2A nilotinib 0.0678512 0.9770019 0.068 NA NA
GNAS nilotinib 0.0799252 0.9770019 0.080 NA NA
BRCA2 nilotinib 0.0840391 0.9770019 0.084 NA NA
EML4 nilotinib 0.0923906 0.9770019 0.092 NA NA
BRAF nilotinib 0.0954859 0.9770019 0.095 NA NA
PDGFRA nilotinib 0.0975395 0.9770019 0.098 NA NA
FLT3 nilotinib 0.1096674 0.9770019 0.110 NA NA
AKT1 nilotinib 0.1211833 0.9770019 0.121 NA NA
IL7R nilotinib 0.1296346 0.9770019 0.130 NA NA
STAG2 nilotinib 0.1488365 0.9770019 0.149 NA NA
SRSF2 nilotinib 0.1489147 0.9770019 0.149 NA NA
BTK nilotinib 0.1714602 0.9770019 0.171 NA NA
FGFR1 nilotinib 0.1727224 0.9770019 0.173 NA NA
ABL1 nilotinib 0.1744480 0.9770019 0.174 NA NA
SMC3 nilotinib 0.1751376 0.9770019 0.175 NA NA
PTCH1 nilotinib 0.1809263 0.9770019 0.181 NA NA
BRCA2 alectinib 0.0425086 0.9803240 0.043
NA
G6PD alectinib 0.0518299 0.9803240 0.052 NA NA
PML alectinib 0.0543074 0.9803240 0.054 NA NA
ATM alectinib 0.0724381 0.9803240 0.072 NA NA
TSC1 alectinib 0.0742726 0.9803240 0.074 NA NA
CSF3R alectinib 0.1095986 0.9803240 0.110 NA NA
ABL1 alectinib 0.1151837 0.9803240 0.115 NA NA
PTEN alectinib 0.1229807 0.9803240 0.123 NA NA
SETD2 alectinib 0.1382390 0.9803240 0.138 NA NA
DDIT3 alectinib 0.1489147 0.9803240 0.149 NA NA
STAT3 alectinib 0.1507856 0.9803240 0.151 NA NA
TET2 alectinib 0.1512811 0.9803240 0.151 NA NA
ERBB4 alectinib 0.1614350 0.9803240 0.161 NA NA
PAX5 alectinib 0.1714602 0.9803240 0.171 NA NA
GNB1 alectinib 0.1714602 0.9803240 0.171 NA NA
CBL alectinib 0.1752442 0.9803240 0.175 NA NA
FBXW7 alectinib 0.1805649 0.9803240 0.181 NA NA
WHSC1 alectinib 0.1895548 0.9803240 0.190 NA NA
SMC3 alectinib 0.1984230 0.9803240 0.198 NA NA
DPYD alectinib 0.2005345 0.9803240 0.201 NA NA
PRPF40B alectinib 0.2036473 0.9803240 0.204 NA NA
JAK2 alectinib 0.2048709 0.9803240 0.205 NA NA
ROS1 alectinib 0.2063404 0.9803240 0.206 NA NA
PDGFRB alectinib 0.2476125 0.9803240 0.248 NA NA
UGT1A1 alectinib 0.2679264 0.9803240 0.268 NA NA
HRAS alectinib 0.2888444 0.9803240 0.289 NA NA
RUNX1 alectinib 0.2962699 0.9803240 0.296 NA NA
IDH1 alectinib 0.3055071 0.9803240 0.306 NA NA
AKT2 alectinib 0.3329216 0.9803240 0.333 NA NA
EGF alectinib 0.3421123 0.9803240 0.342 NA NA
KMT2A alectinib 0.3439441 0.9803240 0.344 NA NA
IDH2 alectinib 0.3710934 0.9803240 0.371 NA NA
SSX1 alectinib 0.3710934 0.9803240 0.371 NA NA
CDK6 alectinib 0.3710934 0.9803240 0.371 NA NA
ERBB3 alectinib 0.3741554 0.9803240 0.374 NA NA
RET alectinib 0.3749953 0.9803240 0.375 NA NA
CREBBP alectinib 0.3807147 0.9803240 0.381 NA NA
NT5C2 alectinib 0.3864762 0.9803240 0.386 NA NA
GNA11 alectinib 0.3864762 0.9803240 0.386 NA NA
IL7R alectinib 0.4017356 0.9803240 0.402 NA NA
FGFR1 alectinib 0.4037318 0.9803240 0.404 NA NA
VHL alectinib 0.4131525 0.9803240 0.413 NA NA
MET alectinib 0.4144753 0.9803240 0.414 NA NA
EGFR alectinib 0.4396324 0.9803240 0.440 NA NA
PTCH1 alectinib 0.4467353 0.9803240 0.447 NA NA
DNAJB1 alectinib 0.4532547 0.9803240 0.453 NA NA
MPL alectinib 0.4862343 0.9803240 0.486 NA NA
NPM1 alectinib 0.4874533 0.9803240 0.487 NA NA
ERBB2 alectinib 0.4884723 0.9803240 0.488 NA NA
NOTCH2 alectinib 0.5003731 0.9803240 0.500 NA NA
BRCA1 alectinib 0.5004224 0.9803240 0.500 NA NA
CDK4 alectinib 0.5024303 0.9803240 0.502 NA NA
CDKN2A alectinib 0.5089566 0.9803240 0.509 NA NA
SF1 alectinib 0.5186050 0.9803240 0.519 NA NA
NRAS alectinib 0.5337384 0.9803240 0.534 NA NA
GATA3 alectinib 0.5457544 0.9803240 0.546 NA NA
MGMT alectinib 0.5509850 0.9803240 0.551 NA NA
STAG2 alectinib 0.5522142 0.9803240 0.552 NA NA
BTK alectinib 0.5522142 0.9803240 0.552 NA NA
RAD21 alectinib 0.5532002 0.9803240 0.553 NA NA
MYD88 alectinib 0.5581846 0.9803240 0.558 NA NA
WT1 alectinib 0.5671762 0.9803240 0.567 NA NA
BCORL1 alectinib 0.5828246 0.9803240 0.583 NA NA
BRAF alectinib 0.6013335 0.9803240 0.601 NA NA
GNAS alectinib 0.6057116 0.9803240 0.606 NA NA
TSC2 alectinib 0.6085760 0.9803240 0.609 NA NA
AKT1 alectinib 0.6227533 0.9803240 0.623 NA NA
XPO1 alectinib 0.6366016 0.9803240 0.637 NA NA
EZH2 alectinib 0.6419688 0.9803240 0.642 NA NA
CD79B alectinib 0.6625206 0.9803240 0.663 NA NA
BCOR alectinib 0.6663415 0.9803240 0.666 NA NA
JAK3 alectinib 0.6708487 0.9803240 0.671 NA NA
CBLB alectinib 0.6726038 0.9803240 0.673 NA NA
EML4 alectinib 0.6782456 0.9803240 0.678 NA NA
JAK1 alectinib 0.6889403 0.9803240 0.689 NA NA
IKZF1 alectinib 0.6950398 0.9803240 0.695 NA NA
ESR1 alectinib 0.6952986 0.9803240 0.695 NA NA
FGFR3 alectinib 0.6969981 0.9803240 0.697 NA NA
CTLA4 alectinib 0.6985354 0.9803240 0.699 NA NA
SETBP1 alectinib 0.7002314 0.9803240 0.700 NA NA
IDH1 nilotinib 0.2112995 0.9805262 0.211 NA NA
MGMT nilotinib 0.2159249 0.9805262 0.216 NA NA
CBL nilotinib 0.2415666 0.9805262 0.242 NA NA
ERBB4 nilotinib 0.2420542 0.9805262 0.242 NA NA
CRLF2 nilotinib 0.2452781 0.9805262 0.245 NA NA
RAD21 nilotinib 0.2683816 0.9805262 0.268 NA NA
JAK2 nilotinib 0.2723606 0.9805262 0.272 NA NA
NOTCH1 nilotinib 0.2741642 0.9805262 0.274 NA NA
CREBBP nilotinib 0.2770808 0.9805262 0.277 NA NA
PRPF8 nilotinib 0.2790163 0.9805262 0.279 NA NA
TSC2 nilotinib 0.2814473 0.9805262 0.281 NA NA
GATA2 alectinib 0.7143930 0.9838674 0.714 NA NA
ETV6 alectinib 0.7236736 0.9838674 0.724 NA NA
DNMT3A alectinib 0.7455421 0.9838674 0.746 NA NA
SRSF2 alectinib 0.7728300 0.9838674 0.773 NA NA
ASXL1 alectinib 0.7749850 0.9838674 0.775 NA NA
KIT alectinib 0.7768479 0.9838674 0.777 NA NA
SH2B3 alectinib 0.7841912 0.9838674 0.784 NA NA
AR alectinib 0.7856963 0.9838674 0.786 NA NA
FLT3 alectinib 0.8034841 0.9838674 0.803 NA NA
TP53 alectinib 0.8090196 0.9838674 0.809 NA NA
CTCF alectinib 0.8116170 0.9838674 0.812 NA NA
CALR alectinib 0.8169613 0.9838674 0.817 NA NA
CRLF2 alectinib 0.8169613 0.9838674 0.817 NA NA
IL7R dabrafenib 0.6592430 0.9839272 0.659 NA NA
RAD21 dabrafenib 0.6633550 0.9839272 0.663 NA NA
STAT3 dabrafenib 0.6726038 0.9839272 0.673 NA NA
ESR1 dabrafenib 0.6726038 0.9839272 0.673 NA NA
ERBB4 dabrafenib 0.6782687 0.9839272 0.678 NA NA
PTEN dabrafenib 0.6932305 0.9839272 0.693 NA NA
CTLA4 dabrafenib 0.6985354 0.9839272 0.699 NA NA
SF3B1 dabrafenib 0.7369989 0.9839272 0.737 NA NA
SMC3 dabrafenib 0.7382595 0.9839272 0.738 NA NA
ASXL1 dabrafenib 0.7594122 0.9839272 0.759 NA NA
SETBP1 dabrafenib 0.7645222 0.9839272 0.765 NA NA
SRSF2 dabrafenib 0.7728300 0.9839272 0.773 NA NA
WHSC1 dabrafenib 0.7786177 0.9839272 0.779 NA NA
CREBBP dabrafenib 0.7956080 0.9839272 0.796 NA NA
PDGFRB dabrafenib 0.7970155 0.9839272 0.797 NA NA
DNAJB1 dabrafenib 0.8025873 0.9839272 0.803 NA NA
SH2B3 dabrafenib 0.8101812 0.9839272 0.810 NA NA
GNA11 dabrafenib 0.8169613 0.9839272 0.817 NA NA
UGT1A1 dabrafenib 0.8186240 0.9839272 0.819 NA NA
PAX5 dabrafenib 0.8197075 0.9839272 0.820 NA NA
SF1 dabrafenib 0.8197075 0.9839272 0.820 NA NA
RET dabrafenib 0.8207531 0.9839272 0.821 NA NA
ALK dabrafenib 0.8226312 0.9839272 0.823 NA NA
ERBB3 dabrafenib 0.8271954 0.9839272 0.827 NA NA
ROS1 pazopanib 0.8795672 0.9861814 0.880 NA NA
SH2B3 bosutinib monohydrate 0.0373364 0.9887914 0.037
NA
KRAS bosutinib monohydrate 0.0811543 0.9887914 0.081 NA NA
IL7R bosutinib monohydrate 0.1473756 0.9887914 0.147 NA NA
ETV6 bosutinib monohydrate 0.1563757 0.9887914 0.156 NA NA
CTCF bosutinib monohydrate 0.1564698 0.9887914 0.156 NA NA
EML4 bosutinib monohydrate 0.1574639 0.9887914 0.157 NA NA
CDKN2A bosutinib monohydrate 0.1604541 0.9887914 0.160 NA NA
TET2 bosutinib monohydrate 0.1682659 0.9887914 0.168 NA NA
ABL1 bosutinib monohydrate 0.1740072 0.9887914 0.174 NA NA
PAX5 bosutinib monohydrate 0.1752442 0.9887914 0.175 NA NA
NRAS bosutinib monohydrate 0.1768343 0.9887914 0.177 NA NA
CREBBP bosutinib monohydrate 0.1796421 0.9887914 0.180 NA NA
SMC3 bosutinib monohydrate 0.1802042 0.9887914 0.180 NA NA
NCOA2 bosutinib monohydrate 0.1877002 0.9887914 0.188 NA NA
STAT3 bosutinib monohydrate 0.1955617 0.9887914 0.196 NA NA
IKZF1 bosutinib monohydrate 0.2025950 0.9887914 0.203 NA NA
KMT2A bosutinib monohydrate 0.2218976 0.9887914 0.222 NA NA
UGT1A1 bosutinib monohydrate 0.2395988 0.9887914 0.240 NA NA
GATA1 bosutinib monohydrate 0.2410324 0.9887914 0.241 NA NA
MYD88 bosutinib monohydrate 0.2415666 0.9887914 0.242 NA NA
JAK2 bosutinib monohydrate 0.2433046 0.9887914 0.243 NA NA
BCORL1 bosutinib monohydrate 0.2446568 0.9887914 0.245 NA NA
CALR bosutinib monohydrate 0.2471600 0.9887914 0.247 NA NA
MYCN bosutinib monohydrate 0.2703441 0.9887914 0.270 NA NA
EZH2 bosutinib monohydrate 0.2780757 0.9887914 0.278 NA NA
PTCH1 bosutinib monohydrate 0.2780850 0.9887914 0.278 NA NA
RET bosutinib monohydrate 0.2818036 0.9887914 0.282 NA NA
PML bosutinib monohydrate 0.3058000 0.9887914 0.306 NA NA
DPYD bosutinib monohydrate 0.3193494 0.9887914 0.319 NA NA
MAP2K1 bosutinib monohydrate 0.3329216 0.9887914 0.333 NA NA
GNA11 bosutinib monohydrate 0.3329216 0.9887914 0.333 NA NA
PRPF8 bosutinib monohydrate 0.3463248 0.9887914 0.346 NA NA
TSC1 bosutinib monohydrate 0.3498070 0.9887914 0.350 NA NA
ZRSR2 bosutinib monohydrate 0.3593968 0.9887914 0.359 NA NA
IDH2 bosutinib monohydrate 0.3710934 0.9887914 0.371 NA NA
SSX1 bosutinib monohydrate 0.3710934 0.9887914 0.371 NA NA
SETBP1 bosutinib monohydrate 0.3784295 0.9887914 0.378 NA NA
MET bosutinib monohydrate 0.3909175 0.9887914 0.391 NA NA
ATM bosutinib monohydrate 0.4081661 0.9887914 0.408 NA NA
GATA2 bosutinib monohydrate 0.4167928 0.9887914 0.417 NA NA
BRAF bosutinib monohydrate 0.4433453 0.9887914 0.443 NA NA
TP53 bosutinib monohydrate 0.4481954 0.9887914 0.448 NA NA
NOTCH2 bosutinib monohydrate 0.4622380 0.9887914 0.462 NA NA
GNB1 bosutinib monohydrate 0.4642143 0.9887914 0.464 NA NA
NOTCH1 bosutinib monohydrate 0.4748248 0.9887914 0.475 NA NA
ASXL1 bosutinib monohydrate 0.4824052 0.9887914 0.482 NA NA
AKT3 bosutinib monohydrate 0.4874533 0.9887914 0.487 NA NA
JAK1 bosutinib monohydrate 0.4881869 0.9887914 0.488 NA NA
BRCA2 bosutinib monohydrate 0.4894264 0.9887914 0.489 NA NA
XPO1 bosutinib monohydrate 0.4941245 0.9887914 0.494 NA NA
BTK bosutinib monohydrate 0.5083316 0.9887914 0.508 NA NA
TSC2 bosutinib monohydrate 0.5144026 0.9887914 0.514 NA NA
FGFR2 bosutinib monohydrate 0.5228167 0.9887914 0.523 NA NA
EGFR bosutinib monohydrate 0.5259598 0.9887914 0.526 NA NA
CTLA4 bosutinib monohydrate 0.5402914 0.9887914 0.540 NA NA
CBLB bosutinib monohydrate 0.5541131 0.9887914 0.554 NA NA
GATA3 bosutinib monohydrate 0.5561538 0.9887914 0.556 NA NA
PDGFB bosutinib monohydrate 0.5581846 0.9887914 0.558 NA NA
ERBB2 bosutinib monohydrate 0.5686660 0.9887914 0.569 NA NA
PDGFRB bosutinib monohydrate 0.5790997 0.9887914 0.579 NA NA
MGMT bosutinib monohydrate 0.5958831 0.9887914 0.596 NA NA
STAG2 bosutinib monohydrate 0.6018450 0.9887914 0.602 NA NA
BCOR bosutinib monohydrate 0.6087261 0.9887914 0.609 NA NA
DNMT3A bosutinib monohydrate 0.6094224 0.9887914 0.609 NA NA
SETD2 bosutinib monohydrate 0.6101784 0.9887914 0.610 NA NA
ALK bosutinib monohydrate 0.6158014 0.9887914 0.616 NA NA
CSF3R bosutinib monohydrate 0.6206179 0.9887914 0.621 NA NA
PIGA bosutinib monohydrate 0.6373519 0.9887914 0.637 NA NA
ERBB4 bosutinib monohydrate 0.6441264 0.9887914 0.644 NA NA
GNAS bosutinib monohydrate 0.6456944 0.9887914 0.646 NA NA
VHL bosutinib monohydrate 0.6527828 0.9887914 0.653 NA NA
FGFR3 bosutinib monohydrate 0.6543166 0.9887914 0.654 NA NA
IDH1 bosutinib monohydrate 0.6625206 0.9887914 0.663 NA NA
MPL bosutinib monohydrate 0.6625206 0.9887914 0.663 NA NA
BRCA1 bosutinib monohydrate 0.6681023 0.9887914 0.668 NA NA
CDK4 bosutinib monohydrate 0.6959426 0.9900099 0.696 NA NA
ESR1 bosutinib monohydrate 0.7115314 0.9900099 0.712 NA NA
AKT1 bosutinib monohydrate 0.7212767 0.9900099 0.721 NA NA
HRAS bosutinib monohydrate 0.7236736 0.9900099 0.724 NA NA
ERBB3 bosutinib monohydrate 0.7411004 0.9900099 0.741 NA NA
SF1 bosutinib monohydrate 0.7655945 0.9900099 0.766 NA NA
G6PD bosutinib monohydrate 0.7728300 0.9900099 0.773 NA NA
CRLF2 bosutinib monohydrate 0.7728300 0.9900099 0.773 NA NA
DDIT3 bosutinib monohydrate 0.7728300 0.9900099 0.773 NA NA
SRSF2 bosutinib monohydrate 0.7728300 0.9900099 0.773 NA NA
KIT bosutinib monohydrate 0.7770588 0.9900099 0.777 NA NA
CXCR4 bosutinib monohydrate 0.8025873 0.9900099 0.803 NA NA
CBL bosutinib monohydrate 0.8025873 0.9900099 0.803 NA NA
FBXW7 bosutinib monohydrate 0.8107543 0.9900099 0.811 NA NA
PIK3CA bosutinib monohydrate 0.8326621 0.9900099 0.833 NA NA
CTNNB1 bosutinib monohydrate 0.8382078 0.9900099 0.838 NA NA
RAD21 bosutinib monohydrate 0.8433133 0.9900099 0.843 NA NA
PTEN bosutinib monohydrate 0.8593387 0.9900099 0.859 NA NA
SMC1A bosutinib monohydrate 0.8596838 0.9900099 0.860 NA NA
FGFR1 bosutinib monohydrate 0.8646653 0.9900099 0.865 NA NA
WHSC1 bosutinib monohydrate 0.8743671 0.9900099 0.874 NA NA
JAK3 bosutinib monohydrate 0.8850299 0.9900099 0.885 NA NA
PRPF40B bosutinib monohydrate 0.8871670 0.9900099 0.887 NA NA
AR bosutinib monohydrate 0.8918595 0.9900099 0.892 NA NA
FLT3 bosutinib monohydrate 0.8919008 0.9900099 0.892 NA NA
NOTCH2 rucaparib 0.0122855 0.9906346 0.012
NA
SMO rucaparib 0.0349018 0.9906346 0.035
NA
PML rucaparib 0.0531547 0.9906346 0.053 NA NA
NCOA2 rucaparib 0.0606020 0.9906346 0.061 NA NA
TP53 rucaparib 0.0649811 0.9906346 0.065 NA NA
STAT3 rucaparib 0.0759270 0.9906346 0.076 NA NA
EML4 rucaparib 0.0806023 0.9906346 0.081 NA NA
TSC2 rucaparib 0.1005657 0.9906346 0.101 NA NA
AKT2 rucaparib 0.1051925 0.9906346 0.105 NA NA
DNMT3A rucaparib 0.1231989 0.9906346 0.123 NA NA
ZRSR2 rucaparib 0.1266305 0.9906346 0.127 NA NA
ABL1 rucaparib 0.1274444 0.9906346 0.127 NA NA
CDKN2A rucaparib 0.1356578 0.9906346 0.136 NA NA
DPYD rucaparib 0.1413838 0.9906346 0.141 NA NA
BTK rucaparib 0.1488365 0.9906346 0.149 NA NA
FBXW7 rucaparib 0.1548213 0.9906346 0.155 NA NA
SF1 rucaparib 0.1714602 0.9906346 0.171 NA NA
GNA11 rucaparib 0.1752442 0.9906346 0.175 NA NA
CDK4 rucaparib 0.1798096 0.9906346 0.180 NA NA
GNAS rucaparib 0.1872701 0.9906346 0.187 NA NA
CTCF rucaparib 0.2048400 0.9906346 0.205 NA NA
JAK2 rucaparib 0.2048709 0.9906346 0.205 NA NA
KIT rucaparib 0.2202589 0.9906346 0.220 NA NA
ETV6 rucaparib 0.2293319 0.9906346 0.229 NA NA
PDGFB rucaparib 0.2415666 0.9906346 0.242 NA NA
GNB1 rucaparib 0.2452781 0.9906346 0.245 NA NA
NPM1 rucaparib 0.2471600 0.9906346 0.247 NA NA
SETD2 rucaparib 0.2479467 0.9906346 0.248 NA NA
STAG2 rucaparib 0.2696061 0.9906346 0.270 NA NA
PTCH1 rucaparib 0.2911042 0.9906346 0.291 NA NA
RUNX1 rucaparib 0.2962699 0.9906346 0.296 NA NA
BCORL1 rucaparib 0.3268698 0.9906346 0.327 NA NA
MAP2K1 rucaparib 0.3329216 0.9906346 0.333 NA NA
AR rucaparib 0.3412685 0.9906346 0.341 NA NA
FGFR1 rucaparib 0.3532136 0.9906346 0.353 NA NA
PDGFRB rucaparib 0.3622401 0.9906346 0.362 NA NA
IDH2 rucaparib 0.3710934 0.9906346 0.371 NA NA
MGMT rucaparib 0.3710934 0.9906346 0.371 NA NA
SSX1 rucaparib 0.3710934 0.9906346 0.371 NA NA
CDK6 rucaparib 0.3710934 0.9906346 0.371 NA NA
EGF rucaparib 0.3749953 0.9906346 0.375 NA NA
CBL rucaparib 0.3827331 0.9906346 0.383 NA NA
IKZF1 rucaparib 0.3956034 0.9906346 0.396 NA NA
IDH1 rucaparib 0.4046568 0.9906346 0.405 NA NA
GATA2 rucaparib 0.4207518 0.9906346 0.421 NA NA
CSF3R rucaparib 0.4259831 0.9906346 0.426 NA NA
RAD21 rucaparib 0.4291606 0.9906346 0.429 NA NA
RET rucaparib 0.4303561 0.9906346 0.430 NA NA
BCOR rucaparib 0.4447379 0.9906346 0.445 NA NA
PTEN rucaparib 0.4507199 0.9906346 0.451 NA NA
CXCR4 rucaparib 0.4532547 0.9906346 0.453 NA NA
DNAJB1 rucaparib 0.4532547 0.9906346 0.453 NA NA
AKT1 rucaparib 0.4605582 0.9906346 0.461 NA NA
DNMT3A cabozantinib 0.9353380 0.9944450 0.935 NA NA
PDGFRB cabozantinib 0.9411712 0.9944450 0.941 NA NA
ASXL1 ponatinib 0.2662760 0.9949427 0.266 NA NA
SETBP1 ponatinib 0.2689034 0.9949427 0.269 NA NA
UGT1A1 ponatinib 0.2964117 0.9961775 0.296 NA NA
NOTCH2 ponatinib 0.2976500 0.9961775 0.298 NA NA
ERBB2 ponatinib 0.3064888 0.9961775 0.306 NA NA
DPYD ponatinib 0.3103990 0.9961775 0.310 NA NA
FBXW7 ponatinib 0.3150527 0.9961775 0.315 NA NA
KRAS ponatinib 0.3291457 0.9961775 0.329 NA NA
GATA2 ponatinib 0.3413493 0.9961775 0.341 NA NA
IDH2 ponatinib 0.3710934 0.9961775 0.371 NA NA
SSX1 ponatinib 0.3710934 0.9961775 0.371 NA NA
CDK6 ponatinib 0.3710934 0.9961775 0.371 NA NA
NT5C2 ponatinib 0.3864762 0.9961775 0.386 NA NA
PML ponatinib 0.3897250 0.9961775 0.390 NA NA
IL7R ponatinib 0.4017356 0.9961775 0.402 NA NA
ROS1 ponatinib 0.4046482 0.9961775 0.405 NA NA
SH2B3 ponatinib 0.4113138 0.9961775 0.411 NA NA
EGF ponatinib 0.4128303 0.9961775 0.413 NA NA
AKT2 dabrafenib 0.8464506 0.9963429 0.846 NA NA
CTNNB1 alectinib 0.8382078 0.9979207 0.838 NA NA
AKT3 alectinib 0.8464506 0.9979207 0.846 NA NA
EGFR cabozantinib 0.9675555 1.0000000 0.968 NA NA
MYCN cabozantinib 1.0000000 1.0000000 1.000 NA NA
VHL cabozantinib 1.0000000 1.0000000 1.000 NA NA
MAP2K1 cabozantinib 1.0000000 1.0000000 1.000 NA NA
GATA3 cabozantinib 1.0000000 1.0000000 1.000 NA NA
JAK2 cabozantinib 1.0000000 1.0000000 1.000 NA NA
IKZF1 temozolomide 0.8151350 1.0000000 0.8151 NA NA
NT5C2 temozolomide 0.8169613 1.0000000 0.8170 NA NA
ALK temozolomide 0.8226312 1.0000000 0.8226 NA NA
GATA1 temozolomide 0.8262384 1.0000000 0.8262 NA NA
GNA11 temozolomide 0.8464506 1.0000000 0.8465 NA NA
SMC1A temozolomide 0.8852339 1.0000000 0.8852 NA NA
PTCH1 temozolomide 0.8874958 1.0000000 0.8875 NA NA
MYCN temozolomide 0.9025233 1.0000000 0.9025 NA NA
SF3B1 temozolomide 0.9108683 1.0000000 0.9109 NA NA
GATA3 temozolomide 0.9252649 1.0000000 0.9253 NA NA
BTK temozolomide 0.9323244 1.0000000 0.9323 NA NA
EZH2 temozolomide 0.9439995 1.0000000 0.9440 NA NA
CREBBP temozolomide 0.9595413 1.0000000 0.9595 NA NA
GATA2 temozolomide 1.0000000 1.0000000 1.0000 NA NA
MYD88 temozolomide 1.0000000 1.0000000 1.0000 NA NA
SETD2 temozolomide 1.0000000 1.0000000 1.0000 NA NA
PDGFB temozolomide 1.0000000 1.0000000 1.0000 NA NA
SH2B3 temozolomide 1.0000000 1.0000000 1.0000 NA NA
G6PD temozolomide 1.0000000 1.0000000 1.0000 NA NA
PIGA temozolomide 1.0000000 1.0000000 1.0000 NA NA
UGT1A1 temozolomide 1.0000000 1.0000000 1.0000 NA NA
CXCR4 temozolomide 1.0000000 1.0000000 1.0000 NA NA
DDIT3 temozolomide 1.0000000 1.0000000 1.0000 NA NA
SRSF2 temozolomide 1.0000000 1.0000000 1.0000 NA NA
RUNX1 ruxolitinib 0.6352563 1.0000000 0.635 NA NA
UGT1A1 ruxolitinib 0.6700376 1.0000000 0.670 NA NA
GATA3 ruxolitinib 0.6871276 1.0000000 0.687 NA NA
SF3B1 ruxolitinib 0.7131901 1.0000000 0.713 NA NA
EZH2 ruxolitinib 0.7254235 1.0000000 0.725 NA NA
EML4 ruxolitinib 0.7372047 1.0000000 0.737 NA NA
KRAS ruxolitinib 0.7492585 1.0000000 0.749 NA NA
JAK2 ruxolitinib 0.7512824 1.0000000 0.751 NA NA
ROS1 ruxolitinib 0.7551582 1.0000000 0.755 NA NA
PRPF8 ruxolitinib 0.7640767 1.0000000 0.764 NA NA
GATA1 ruxolitinib 0.7687598 1.0000000 0.769 NA NA
NT5C2 ruxolitinib 0.7728300 1.0000000 0.773 NA NA
SRSF2 ruxolitinib 0.7728300 1.0000000 0.773 NA NA
WT1 ruxolitinib 0.7747957 1.0000000 0.775 NA NA
TSC2 ruxolitinib 0.7770820 1.0000000 0.777 NA NA
PRPF40B ruxolitinib 0.7993057 1.0000000 0.799 NA NA
JAK3 ruxolitinib 0.8008203 1.0000000 0.801 NA NA
CXCR4 ruxolitinib 0.8025873 1.0000000 0.803 NA NA
DNAJB1 ruxolitinib 0.8025873 1.0000000 0.803 NA NA
CRLF2 ruxolitinib 0.8169613 1.0000000 0.817 NA NA
SETBP1 ruxolitinib 0.8250003 1.0000000 0.825 NA NA
ETV6 ruxolitinib 0.8320040 1.0000000 0.832 NA NA
MYCN ruxolitinib 0.8345316 1.0000000 0.835 NA NA
NOTCH2 ruxolitinib 0.8541769 1.0000000 0.854 NA NA
CDKN2A ruxolitinib 0.8640420 1.0000000 0.864 NA NA
KIT ruxolitinib 0.8649650 1.0000000 0.865 NA NA
SETD2 ruxolitinib 0.8691731 1.0000000 0.869 NA NA
ASXL1 ruxolitinib 0.8738175 1.0000000 0.874 NA NA
AKT1 ruxolitinib 0.8807910 1.0000000 0.881 NA NA
NOTCH1 ruxolitinib 0.9148401 1.0000000 0.915 NA NA
BTK ruxolitinib 0.9323244 1.0000000 0.932 NA NA
FLT3 ruxolitinib 0.9353380 1.0000000 0.935 NA NA
FGFR3 ruxolitinib 0.9379273 1.0000000 0.938 NA NA
GATA2 ruxolitinib 0.9416529 1.0000000 0.942 NA NA
IL7R ruxolitinib 0.9554201 1.0000000 0.955 NA NA
PTCH1 ruxolitinib 0.9662831 1.0000000 0.966 NA NA
TP53 ruxolitinib 1.0000000 1.0000000 1.000 NA NA
NPM1 ruxolitinib 1.0000000 1.0000000 1.000 NA NA
RAD21 ruxolitinib 1.0000000 1.0000000 1.000 NA NA
VHL ruxolitinib 1.0000000 1.0000000 1.000 NA NA
MAP2K1 ruxolitinib 1.0000000 1.0000000 1.000 NA NA
G6PD ruxolitinib 1.0000000 1.0000000 1.000 NA NA
MPL ruxolitinib 1.0000000 1.0000000 1.000 NA NA
CDK4 ruxolitinib 1.0000000 1.0000000 1.000 NA NA
AR gefitinib 0.0486896 1.0000000 0.049
NA
KIT gefitinib 0.0893335 1.0000000 0.089 NA NA
ESR1 gefitinib 0.0960923 1.0000000 0.096 NA NA
GATA2 gefitinib 0.1043767 1.0000000 0.104 NA NA
SF1 gefitinib 0.1116118 1.0000000 0.112 NA NA
TP53 gefitinib 0.1299556 1.0000000 0.130 NA NA
STAG2 gefitinib 0.1314573 1.0000000 0.131 NA NA
PDGFRB gefitinib 0.1321661 1.0000000 0.132 NA NA
ALK gefitinib 0.1322138 1.0000000 0.132 NA NA
FGFR2 gefitinib 0.1387688 1.0000000 0.139 NA NA
FLT3 gefitinib 0.1441929 1.0000000 0.144 NA NA
JAK1 gefitinib 0.1472235 1.0000000 0.147 NA NA
IL7R gefitinib 0.1473756 1.0000000 0.147 NA NA
CSF3R gefitinib 0.1791092 1.0000000 0.179 NA NA
GNB1 gefitinib 0.1876828 1.0000000 0.188 NA NA
EGF gefitinib 0.1928758 1.0000000 0.193 NA NA
EML4 gefitinib 0.2008903 1.0000000 0.201 NA NA
IKZF1 gefitinib 0.2025950 1.0000000 0.203 NA NA
ASXL1 gefitinib 0.2060898 1.0000000 0.206 NA NA
CTNNB1 gefitinib 0.2097372 1.0000000 0.210 NA NA
IDH1 gefitinib 0.2112995 1.0000000 0.211 NA NA
ZRSR2 gefitinib 0.2217000 1.0000000 0.222 NA NA
SF3B1 gefitinib 0.2366172 1.0000000 0.237 NA NA
GATA1 gefitinib 0.2410324 1.0000000 0.241 NA NA
PDGFB gefitinib 0.2415666 1.0000000 0.242 NA NA
ERBB4 gefitinib 0.2481548 1.0000000 0.248 NA NA
VHL gefitinib 0.2938258 1.0000000 0.294 NA NA
FGFR3 gefitinib 0.2961130 1.0000000 0.296 NA NA
RAD21 gefitinib 0.3230126 1.0000000 0.323 NA NA
PIK3CA gefitinib 0.3406277 1.0000000 0.341 NA NA
SMO gefitinib 0.3424858 1.0000000 0.342 NA NA
WT1 gefitinib 0.3709136 1.0000000 0.371 NA NA
IDH2 gefitinib 0.3710934 1.0000000 0.371 NA NA
SSX1 gefitinib 0.3710934 1.0000000 0.371 NA NA
EGFR gefitinib 0.3746163 1.0000000 0.375 NA NA
SMC1A gefitinib 0.3767591 1.0000000 0.377 NA NA
MPL gefitinib 0.3827331 1.0000000 0.383 NA NA
EZH2 gefitinib 0.3855466 1.0000000 0.386 NA NA
BTK gefitinib 0.3950916 1.0000000 0.395 NA NA
SETD2 gefitinib 0.3954929 1.0000000 0.395 NA NA
PRPF8 gefitinib 0.4195470 1.0000000 0.420 NA NA
FBXW7 gefitinib 0.4207755 1.0000000 0.421 NA NA
NOTCH2 gefitinib 0.4257818 1.0000000 0.426 NA NA
CDK4 gefitinib 0.4344457 1.0000000 0.434 NA NA
TSC2 gefitinib 0.4571931 1.0000000 0.457 NA NA
NRAS gefitinib 0.4699489 1.0000000 0.470 NA NA
CD79B gefitinib 0.4874533 1.0000000 0.487 NA NA
BRCA1 gefitinib 0.5004663 1.0000000 0.500 NA NA
SETBP1 gefitinib 0.5253819 1.0000000 0.525 NA NA
NCOA2 gefitinib 0.5326028 1.0000000 0.533 NA NA
BRCA2 gefitinib 0.5419273 1.0000000 0.542 NA NA
TSC1 gefitinib 0.5518589 1.0000000 0.552 NA NA
GATA3 gefitinib 0.5561538 1.0000000 0.556 NA NA
MYD88 gefitinib 0.5581846 1.0000000 0.558 NA NA
MAP2K1 gefitinib 0.5612758 1.0000000 0.561 NA NA
ABL1 gefitinib 0.5686182 1.0000000 0.569 NA NA
ERBB2 gefitinib 0.5686660 1.0000000 0.569 NA NA
ERBB3 gefitinib 0.5703202 1.0000000 0.570 NA NA
KRAS gefitinib 0.5740869 1.0000000 0.574 NA NA
TET2 gefitinib 0.5897916 1.0000000 0.590 NA NA
RET gefitinib 0.5904816 1.0000000 0.590 NA NA
FGFR1 gefitinib 0.6091301 1.0000000 0.609 NA NA
NOTCH1 gefitinib 0.6097258 1.0000000 0.610 NA NA
DPYD gefitinib 0.6316134 1.0000000 0.632 NA NA
ETV6 gefitinib 0.6366016 1.0000000 0.637 NA NA
AKT1 gefitinib 0.6385921 1.0000000 0.639 NA NA
SMC3 gefitinib 0.6411217 1.0000000 0.641 NA NA
BCORL1 gefitinib 0.6981577 1.0000000 0.698 NA NA
GNAS gefitinib 0.7040976 1.0000000 0.704 NA NA
MYCN gefitinib 0.7133032 1.0000000 0.713 NA NA
SH2B3 gefitinib 0.7133032 1.0000000 0.713 NA NA
AKT3 gefitinib 0.7236736 1.0000000 0.724 NA NA
DNMT3A gefitinib 0.7334056 1.0000000 0.733 NA NA
PAX8 gefitinib 0.7655945 1.0000000 0.766 NA NA
G6PD gefitinib 0.7728300 1.0000000 0.773 NA NA
CRLF2 gefitinib 0.7728300 1.0000000 0.773 NA NA
DDIT3 gefitinib 0.7728300 1.0000000 0.773 NA NA
SRSF2 gefitinib 0.7728300 1.0000000 0.773 NA NA
PRPF40B gefitinib 0.7765791 1.0000000 0.777 NA NA
BRAF gefitinib 0.8022452 1.0000000 0.802 NA NA
CXCR4 gefitinib 0.8025873 1.0000000 0.803 NA NA
CBL gefitinib 0.8025873 1.0000000 0.803 NA NA
XPO1 gefitinib 0.8197075 1.0000000 0.820 NA NA
CTCF gefitinib 0.8229566 1.0000000 0.823 NA NA
KMT2A gefitinib 0.8347625 1.0000000 0.835 NA NA
PAX5 gefitinib 0.8464506 1.0000000 0.846 NA NA
GNA11 gefitinib 0.8464506 1.0000000 0.846 NA NA
STAT3 gefitinib 0.8533074 1.0000000 0.853 NA NA
MGMT gefitinib 0.8596838 1.0000000 0.860 NA NA
BCOR gefitinib 0.8645140 1.0000000 0.865 NA NA
WHSC1 gefitinib 0.8743671 1.0000000 0.874 NA NA
JAK3 gefitinib 0.8850299 1.0000000 0.885 NA NA
PML gefitinib 0.8913918 1.0000000 0.891 NA NA
CDKN2A gefitinib 0.8936627 1.0000000 0.894 NA NA
CREBBP gefitinib 0.9009176 1.0000000 0.901 NA NA
PTEN gefitinib 0.9059535 1.0000000 0.906 NA NA
MET gefitinib 0.9240541 1.0000000 0.924 NA NA
PTCH1 gefitinib 0.9248583 1.0000000 0.925 NA NA
ROS1 gefitinib 0.9280030 1.0000000 0.928 NA NA
CBLB gefitinib 1.0000000 1.0000000 1.000 NA NA
ATM gefitinib 1.0000000 1.0000000 1.000 NA NA
PDGFRA gefitinib 1.0000000 1.0000000 1.000 NA NA
CALR gefitinib 1.0000000 1.0000000 1.000 NA NA
NPM1 gefitinib 1.0000000 1.0000000 1.000 NA NA
NT5C2 gefitinib 1.0000000 1.0000000 1.000 NA NA
UGT1A1 gefitinib 1.0000000 1.0000000 1.000 NA NA
PIGA gefitinib 1.0000000 1.0000000 1.000 NA NA
JAK2 gefitinib 1.0000000 1.0000000 1.000 NA NA
HRAS gefitinib 1.0000000 1.0000000 1.000 NA NA
CTLA4 gefitinib 1.0000000 1.0000000 1.000 NA NA
AKT2 gefitinib 1.0000000 1.0000000 1.000 NA NA
NT5C2 rucaparib 0.4874533 1.0000000 0.487 NA NA
ROS1 rucaparib 0.4953461 1.0000000 0.495 NA NA
ERBB4 rucaparib 0.5002518 1.0000000 0.500 NA NA
MET rucaparib 0.5002799 1.0000000 0.500 NA NA
BRAF rucaparib 0.5138566 1.0000000 0.514 NA NA
NRAS rucaparib 0.5337384 1.0000000 0.534 NA NA
MYCN rucaparib 0.5402914 1.0000000 0.540 NA NA
VHL rucaparib 0.5565355 1.0000000 0.557 NA NA
WT1 rucaparib 0.5671762 1.0000000 0.567 NA NA
GATA3 rucaparib 0.5735551 1.0000000 0.574 NA NA
PDGFRA rucaparib 0.5800116 1.0000000 0.580 NA NA
PRPF8 rucaparib 0.5937641 1.0000000 0.594 NA NA
G6PD rucaparib 0.5958831 1.0000000 0.596 NA NA
EZH2 rucaparib 0.6229261 1.0000000 0.623 NA NA
MPL rucaparib 0.6352563 1.0000000 0.635 NA NA
PIGA rucaparib 0.6373519 1.0000000 0.637 NA NA
FGFR2 rucaparib 0.6592430 1.0000000 0.659 NA NA
KMT2A rucaparib 0.6608098 1.0000000 0.661 NA NA
SMC1A rucaparib 0.6650055 1.0000000 0.665 NA NA
SF3B1 rucaparib 0.6684229 1.0000000 0.668 NA NA
IL7R rucaparib 0.6719999 1.0000000 0.672 NA NA
ERBB2 rucaparib 0.6884976 1.0000000 0.688 NA NA
ATM rucaparib 0.6947785 1.0000000 0.695 NA NA
ERBB3 rucaparib 0.7093196 1.0000000 0.709 NA NA
WHSC1 rucaparib 0.7256055 1.0000000 0.726 NA NA
SETBP1 rucaparib 0.7363107 1.0000000 0.736 NA NA
PAX8 rucaparib 0.7491191 1.0000000 0.749 NA NA
KRAS rucaparib 0.7613129 1.0000000 0.761 NA NA
DDIT3 rucaparib 0.7728300 1.0000000 0.773 NA NA
XPO1 rucaparib 0.7989067 1.0000000 0.799 NA NA
CBLB rucaparib 0.7998461 1.0000000 0.800 NA NA
TET2 rucaparib 0.8098941 1.0000000 0.810 NA NA
CALR rucaparib 0.8169613 1.0000000 0.817 NA NA
EGFR rucaparib 0.8186882 1.0000000 0.819 NA NA
FGFR3 rucaparib 0.8228454 1.0000000 0.823 NA NA
BRCA2 rucaparib 0.8323233 1.0000000 0.832 NA NA
PIK3CA rucaparib 0.8403422 1.0000000 0.840 NA NA
NOTCH1 rucaparib 0.8463472 1.0000000 0.846 NA NA
HRAS rucaparib 0.8464506 1.0000000 0.846 NA NA
CREBBP rucaparib 0.8947233 1.0000000 0.895 NA NA
JAK3 rucaparib 0.8996189 1.0000000 0.900 NA NA
ASXL1 rucaparib 0.9115132 1.0000000 0.912 NA NA
SMC3 rucaparib 0.9180546 1.0000000 0.918 NA NA
TSC1 rucaparib 0.9271846 1.0000000 0.927 NA NA
ALK rucaparib 0.9287719 1.0000000 0.929 NA NA
UGT1A1 rucaparib 0.9320871 1.0000000 0.932 NA NA
PRPF40B rucaparib 0.9324613 1.0000000 0.932 NA NA
SH2B3 rucaparib 0.9361863 1.0000000 0.936 NA NA
ESR1 rucaparib 0.9385029 1.0000000 0.939 NA NA
BRCA1 rucaparib 0.9589731 1.0000000 0.959 NA NA
JAK1 rucaparib 0.9598565 1.0000000 0.960 NA NA
FLT3 rucaparib 1.0000000 1.0000000 1.000 NA NA
PAX5 rucaparib 1.0000000 1.0000000 1.000 NA NA
CTNNB1 rucaparib 1.0000000 1.0000000 1.000 NA NA
AKT3 rucaparib 1.0000000 1.0000000 1.000 NA NA
CRLF2 rucaparib 1.0000000 1.0000000 1.000 NA NA
MYD88 rucaparib 1.0000000 1.0000000 1.000 NA NA
GATA1 rucaparib 1.0000000 1.0000000 1.000 NA NA
CD79B rucaparib 1.0000000 1.0000000 1.000 NA NA
CTLA4 rucaparib 1.0000000 1.0000000 1.000 NA NA
SRSF2 rucaparib 1.0000000 1.0000000 1.000 NA NA
ERBB2 belinostat 0.0359196 1.0000000 0.036
NA
TP53 belinostat 0.0495767 1.0000000 0.050
NA
DNMT3A belinostat 0.0500164 1.0000000 0.050 NA NA
IL7R belinostat 0.0580240 1.0000000 0.058 NA NA
PTEN belinostat 0.0791666 1.0000000 0.079 NA NA
CSF3R belinostat 0.0922923 1.0000000 0.092 NA NA
SF3B1 belinostat 0.1015512 1.0000000 0.102 NA NA
NPM1 belinostat 0.1051925 1.0000000 0.105 NA NA
EML4 belinostat 0.1173639 1.0000000 0.117 NA NA
ROS1 belinostat 0.1189430 1.0000000 0.119 NA NA
SMO belinostat 0.1259398 1.0000000 0.126 NA NA
MPL belinostat 0.1637344 1.0000000 0.164 NA NA
AKT2 belinostat 0.1752442 1.0000000 0.175 NA NA
CBL belinostat 0.1752442 1.0000000 0.175 NA NA
GATA3 belinostat 0.1936528 1.0000000 0.194 NA NA
CXCR4 belinostat 0.2112995 1.0000000 0.211 NA NA
DNAJB1 belinostat 0.2112995 1.0000000 0.211 NA NA
TSC1 belinostat 0.2284617 1.0000000 0.228 NA NA
RAD21 belinostat 0.2356447 1.0000000 0.236 NA NA
PAX8 belinostat 0.2409547 1.0000000 0.241 NA NA
MYD88 belinostat 0.2415666 1.0000000 0.242 NA NA
JAK3 belinostat 0.2521142 1.0000000 0.252 NA NA
ESR1 belinostat 0.2615722 1.0000000 0.262 NA NA
TET2 belinostat 0.2870148 1.0000000 0.287 NA NA
HRAS belinostat 0.2888444 1.0000000 0.289 NA NA
AR belinostat 0.2913240 1.0000000 0.291 NA NA
XPO1 belinostat 0.2986177 1.0000000 0.299 NA NA
PTCH1 belinostat 0.3220200 1.0000000 0.322 NA NA
CDKN2A belinostat 0.3373325 1.0000000 0.337 NA NA
JAK1 belinostat 0.3389006 1.0000000 0.339 NA NA
NCOA2 belinostat 0.3637223 1.0000000 0.364 NA NA
FGFR3 belinostat 0.3640864 1.0000000 0.364 NA NA
SETBP1 belinostat 0.3670945 1.0000000 0.367 NA NA
WT1 belinostat 0.3709136 1.0000000 0.371 NA NA
FLT3 belinostat 0.3709752 1.0000000 0.371 NA NA
GATA1 belinostat 0.3777807 1.0000000 0.378 NA NA
NT5C2 belinostat 0.3864762 1.0000000 0.386 NA NA
EGFR belinostat 0.3930147 1.0000000 0.393 NA NA
WHSC1 belinostat 0.3987861 1.0000000 0.399 NA NA
BRAF belinostat 0.4241885 1.0000000 0.424 NA NA
ASXL1 belinostat 0.4271624 1.0000000 0.427 NA NA
PML belinostat 0.4445821 1.0000000 0.445 NA NA
STAT3 belinostat 0.4468728 1.0000000 0.447 NA NA
CTCF belinostat 0.4562551 1.0000000 0.456 NA NA
STAG2 belinostat 0.4567504 1.0000000 0.457 NA NA
PDGFRA belinostat 0.4698549 1.0000000 0.470 NA NA
CALR belinostat 0.4874533 1.0000000 0.487 NA NA
CRLF2 belinostat 0.4874533 1.0000000 0.487 NA NA
GNA11 belinostat 0.4874533 1.0000000 0.487 NA NA
EGF belinostat 0.4900103 1.0000000 0.490 NA NA
SMC3 belinostat 0.5036550 1.0000000 0.504 NA NA
CREBBP belinostat 0.5058991 1.0000000 0.506 NA NA
JAK2 belinostat 0.5261475 1.0000000 0.526 NA NA
KIT belinostat 0.5329271 1.0000000 0.533 NA NA
MGMT belinostat 0.5509850 1.0000000 0.551 NA NA
MAP2K1 belinostat 0.5612758 1.0000000 0.561 NA NA
SMC1A belinostat 0.5958831 1.0000000 0.596 NA NA
VHL belinostat 0.6004018 1.0000000 0.600 NA NA
KMT2A belinostat 0.6155746 1.0000000 0.616 NA NA
PRPF8 belinostat 0.6169206 1.0000000 0.617 NA NA
AKT1 belinostat 0.6227533 1.0000000 0.623 NA NA
ATM belinostat 0.6261757 1.0000000 0.626 NA NA
RUNX1 belinostat 0.6352563 1.0000000 0.635 NA NA
BTK belinostat 0.6366016 1.0000000 0.637 NA NA
TSC2 belinostat 0.6411217 1.0000000 0.641 NA NA
ERBB3 belinostat 0.6439862 1.0000000 0.644 NA NA
IDH1 belinostat 0.6605492 1.0000000 0.661 NA NA
CD79B belinostat 0.6625206 1.0000000 0.663 NA NA
ABL1 belinostat 0.6851355 1.0000000 0.685 NA NA
IKZF1 belinostat 0.6950398 1.0000000 0.695 NA NA
GNB1 belinostat 0.6985354 1.0000000 0.699 NA NA
CTLA4 belinostat 0.6985354 1.0000000 0.699 NA NA
SETD2 belinostat 0.7241276 1.0000000 0.724 NA NA
CDK4 belinostat 0.7373721 1.0000000 0.737 NA NA
NOTCH1 belinostat 0.7426322 1.0000000 0.743 NA NA
SRSF2 belinostat 0.7728300 1.0000000 0.773 NA NA
ETV6 belinostat 0.7998461 1.0000000 0.800 NA NA
FBXW7 belinostat 0.8017632 1.0000000 0.802 NA NA
PAX5 belinostat 0.8197075 1.0000000 0.820 NA NA
GNAS belinostat 0.8261742 1.0000000 0.826 NA NA
PRPF40B belinostat 0.8296028 1.0000000 0.830 NA NA
MYCN belinostat 0.8345316 1.0000000 0.835 NA NA
KRAS belinostat 0.8425079 1.0000000 0.843 NA NA
ERBB4 belinostat 0.8468497 1.0000000 0.847 NA NA
MET belinostat 0.8488272 1.0000000 0.849 NA NA
FGFR2 belinostat 0.8501067 1.0000000 0.850 NA NA
CBLB belinostat 0.8533074 1.0000000 0.853 NA NA
RET belinostat 0.8743671 1.0000000 0.874 NA NA
SF1 belinostat 0.8972790 1.0000000 0.897 NA NA
NOTCH2 belinostat 0.9024811 1.0000000 0.902 NA NA
BRCA2 belinostat 0.9053952 1.0000000 0.905 NA NA
UGT1A1 belinostat 0.9145888 1.0000000 0.915 NA NA
ALK belinostat 0.9249291 1.0000000 0.925 NA NA
EZH2 belinostat 0.9470426 1.0000000 0.947 NA NA
BRCA1 belinostat 0.9548441 1.0000000 0.955 NA NA
PDGFRB belinostat 0.9589731 1.0000000 0.959 NA NA
BCORL1 belinostat 0.9702715 1.0000000 0.970 NA NA
DPYD belinostat 0.9746104 1.0000000 0.975 NA NA
BCOR belinostat 0.9767628 1.0000000 0.977 NA NA
IDH2 belinostat 1.0000000 1.0000000 1.000 NA NA
CTNNB1 belinostat 1.0000000 1.0000000 1.000 NA NA
NRAS belinostat 1.0000000 1.0000000 1.000 NA NA
AKT3 belinostat 1.0000000 1.0000000 1.000 NA NA
GATA2 belinostat 1.0000000 1.0000000 1.000 NA NA
FGFR1 belinostat 1.0000000 1.0000000 1.000 NA NA
SSX1 belinostat 1.0000000 1.0000000 1.000 NA NA
PDGFB belinostat 1.0000000 1.0000000 1.000 NA NA
SH2B3 belinostat 1.0000000 1.0000000 1.000 NA NA
G6PD belinostat 1.0000000 1.0000000 1.000 NA NA
DDIT3 belinostat 1.0000000 1.0000000 1.000 NA NA
ZRSR2 belinostat 1.0000000 1.0000000 1.000 NA NA
CDK6 belinostat 1.0000000 1.0000000 1.000 NA NA
ATM dabrafenib 0.8627519 1.0000000 0.863 NA NA
AKT1 dabrafenib 0.8807910 1.0000000 0.881 NA NA
PDGFRA dabrafenib 0.9036365 1.0000000 0.904 NA NA
VHL dabrafenib 0.9089940 1.0000000 0.909 NA NA
TSC1 dabrafenib 0.9271846 1.0000000 0.927 NA NA
FGFR2 dabrafenib 0.9272645 1.0000000 0.927 NA NA
FGFR3 dabrafenib 0.9300799 1.0000000 0.930 NA NA
IKZF1 dabrafenib 0.9378793 1.0000000 0.938 NA NA
NRAS dabrafenib 0.9407729 1.0000000 0.941 NA NA
IDH2 dabrafenib 1.0000000 1.0000000 1.000 NA NA
CALR dabrafenib 1.0000000 1.0000000 1.000 NA NA
BCOR dabrafenib 1.0000000 1.0000000 1.000 NA NA
FBXW7 dabrafenib 1.0000000 1.0000000 1.000 NA NA
BTK dabrafenib 1.0000000 1.0000000 1.000 NA NA
PIGA dabrafenib 1.0000000 1.0000000 1.000 NA NA
MPL dabrafenib 1.0000000 1.0000000 1.000 NA NA
KIT dabrafenib 1.0000000 1.0000000 1.000 NA NA
ERBB3 palbociclib 0.0128240 1.0000000 0.013
NA
SMO palbociclib 0.0450696 1.0000000 0.045
NA
ALK palbociclib 0.0553726 1.0000000 0.055 NA NA
VHL palbociclib 0.0695285 1.0000000 0.070 NA NA
NCOA2 palbociclib 0.0750492 1.0000000 0.075 NA NA
CREBBP palbociclib 0.0836029 1.0000000 0.084 NA NA
STAG2 palbociclib 0.0954832 1.0000000 0.095 NA NA
MGMT palbociclib 0.1051925 1.0000000 0.105 NA NA
BTK palbociclib 0.1098194 1.0000000 0.110 NA NA
SRSF2 palbociclib 0.1489147 1.0000000 0.149 NA NA
GNB1 palbociclib 0.1876828 1.0000000 0.188 NA NA
SMC1A palbociclib 0.1939309 1.0000000 0.194 NA NA
CBLB palbociclib 0.1955617 1.0000000 0.196 NA NA
CBL palbociclib 0.2112995 1.0000000 0.211 NA NA
BRAF palbociclib 0.2246703 1.0000000 0.225 NA NA
SF3B1 palbociclib 0.2315445 1.0000000 0.232 NA NA
SMC3 palbociclib 0.2438864 1.0000000 0.244 NA NA
NT5C2 palbociclib 0.2471600 1.0000000 0.247 NA NA
BRCA2 palbociclib 0.2502301 1.0000000 0.250 NA NA
TET2 palbociclib 0.2550452 1.0000000 0.255 NA NA
IL7R palbociclib 0.2818036 1.0000000 0.282 NA NA
JAK1 palbociclib 0.2840336 1.0000000 0.284 NA NA
EZH2 palbociclib 0.2976215 1.0000000 0.298 NA NA
BCOR palbociclib 0.2986177 1.0000000 0.299 NA NA
FGFR1 palbociclib 0.3052255 1.0000000 0.305 NA NA
IKZF1 palbociclib 0.3216665 1.0000000 0.322 NA NA
BCORL1 palbociclib 0.3319586 1.0000000 0.332 NA NA
EGFR palbociclib 0.3371061 1.0000000 0.337 NA NA
RET palbociclib 0.3502014 1.0000000 0.350 NA NA
STAT3 palbociclib 0.3525421 1.0000000 0.353 NA NA
ZRSR2 palbociclib 0.3593968 1.0000000 0.359 NA NA
IDH2 palbociclib 0.3710934 1.0000000 0.371 NA NA
MAP2K1 palbociclib 0.3827331 1.0000000 0.383 NA NA
CRLF2 palbociclib 0.3864762 1.0000000 0.386 NA NA
GATA2 palbociclib 0.3950916 1.0000000 0.395 NA NA
ROS1 palbociclib 0.4125285 1.0000000 0.413 NA NA
PIK3CA palbociclib 0.4220345 1.0000000 0.422 NA NA
CSF3R palbociclib 0.4366766 1.0000000 0.437 NA NA
CXCR4 palbociclib 0.4532547 1.0000000 0.453 NA NA
FGFR3 palbociclib 0.4577319 1.0000000 0.458 NA NA
DNMT3A palbociclib 0.4735404 1.0000000 0.474 NA NA
AKT3 palbociclib 0.4874533 1.0000000 0.487 NA NA
CD79B palbociclib 0.4874533 1.0000000 0.487 NA NA
TSC2 palbociclib 0.4882430 1.0000000 0.488 NA NA
PTCH1 palbociclib 0.4898114 1.0000000 0.490 NA NA
FGFR2 palbociclib 0.5334165 1.0000000 0.533 NA NA
SH2B3 palbociclib 0.5402914 1.0000000 0.540 NA NA
CTLA4 palbociclib 0.5402914 1.0000000 0.540 NA NA
SSX1 palbociclib 0.5402914 1.0000000 0.540 NA NA
TP53 palbociclib 0.5418333 1.0000000 0.542 NA NA
SETBP1 palbociclib 0.5439054 1.0000000 0.544 NA NA
MET palbociclib 0.5473180 1.0000000 0.547 NA NA
MYD88 palbociclib 0.5581846 1.0000000 0.558 NA NA
KRAS palbociclib 0.5595746 1.0000000 0.560 NA NA
AKT2 palbociclib 0.5612758 1.0000000 0.561 NA NA
EML4 palbociclib 0.6140775 1.0000000 0.614 NA NA
ASXL1 palbociclib 0.6277256 1.0000000 0.628 NA NA
AR palbociclib 0.6341948 1.0000000 0.634 NA NA
PIGA palbociclib 0.6373519 1.0000000 0.637 NA NA
KIT palbociclib 0.6403709 1.0000000 0.640 NA NA
FLT3 palbociclib 0.6439862 1.0000000 0.644 NA NA
PDGFRA palbociclib 0.6439862 1.0000000 0.644 NA NA
TSC1 palbociclib 0.6477157 1.0000000 0.648 NA NA
NOTCH2 palbociclib 0.6580726 1.0000000 0.658 NA NA
IDH1 palbociclib 0.6625206 1.0000000 0.663 NA NA
MPL palbociclib 0.6625206 1.0000000 0.663 NA NA
GNAS palbociclib 0.6696433 1.0000000 0.670 NA NA
ETV6 palbociclib 0.6711255 1.0000000 0.671 NA NA
EGF palbociclib 0.6712469 1.0000000 0.671 NA NA
FBXW7 palbociclib 0.6872879 1.0000000 0.687 NA NA
WHSC1 palbociclib 0.6933660 1.0000000 0.693 NA NA
ESR1 palbociclib 0.6952986 1.0000000 0.695 NA NA
MYCN palbociclib 0.7133032 1.0000000 0.713 NA NA
CDKN2A palbociclib 0.7220822 1.0000000 0.722 NA NA
HRAS palbociclib 0.7236736 1.0000000 0.724 NA NA
UGT1A1 palbociclib 0.7316568 1.0000000 0.732 NA NA
JAK3 palbociclib 0.7346140 1.0000000 0.735 NA NA
GATA1 palbociclib 0.7373721 1.0000000 0.737 NA NA
PAX8 palbociclib 0.7655945 1.0000000 0.766 NA NA
ATM palbociclib 0.7670996 1.0000000 0.767 NA NA
ABL1 palbociclib 0.7728300 1.0000000 0.773 NA NA
NOTCH1 palbociclib 0.7868350 1.0000000 0.787 NA NA
SETD2 palbociclib 0.7869801 1.0000000 0.787 NA NA
PDGFRB palbociclib 0.7963888 1.0000000 0.796 NA NA
CTNNB1 palbociclib 0.8119822 1.0000000 0.812 NA NA
BRCA1 palbociclib 0.8157105 1.0000000 0.816 NA NA
CALR palbociclib 0.8169613 1.0000000 0.817 NA NA
GATA3 palbociclib 0.8316391 1.0000000 0.832 NA NA
ERBB4 palbociclib 0.8438380 1.0000000 0.844 NA NA
PAX5 palbociclib 0.8464506 1.0000000 0.846 NA NA
GNA11 palbociclib 0.8464506 1.0000000 0.846 NA NA
ERBB2 palbociclib 0.8588936 1.0000000 0.859 NA NA
G6PD palbociclib 0.8596838 1.0000000 0.860 NA NA
PRPF40B palbociclib 0.8768661 1.0000000 0.877 NA NA
PRPF8 palbociclib 0.8929799 1.0000000 0.893 NA NA
DPYD palbociclib 0.9069783 1.0000000 0.907 NA NA
WT1 palbociclib 0.9351699 1.0000000 0.935 NA NA
CTCF palbociclib 0.9366772 1.0000000 0.937 NA NA
PTEN palbociclib 0.9528947 1.0000000 0.953 NA NA
KMT2A palbociclib 0.9634074 1.0000000 0.963 NA NA
PML palbociclib 1.0000000 1.0000000 1.000 NA NA
NPM1 palbociclib 1.0000000 1.0000000 1.000 NA NA
NRAS palbociclib 1.0000000 1.0000000 1.000 NA NA
RAD21 palbociclib 1.0000000 1.0000000 1.000 NA NA
XPO1 palbociclib 1.0000000 1.0000000 1.000 NA NA
SF1 palbociclib 1.0000000 1.0000000 1.000 NA NA
CDK4 palbociclib 1.0000000 1.0000000 1.000 NA NA
DDIT3 palbociclib 1.0000000 1.0000000 1.000 NA NA
JAK2 palbociclib 1.0000000 1.0000000 1.000 NA NA
AKT1 palbociclib 1.0000000 1.0000000 1.000 NA NA
SMC1A alectinib 0.8852339 1.0000000 0.885 NA NA
PDGFRA alectinib 0.9118752 1.0000000 0.912 NA NA
KRAS alectinib 0.9166007 1.0000000 0.917 NA NA
NOTCH1 alectinib 0.9188042 1.0000000 0.919 NA NA
ALK alectinib 0.9194853 1.0000000 0.919 NA NA
SF3B1 alectinib 0.9201477 1.0000000 0.920 NA NA
PRPF8 alectinib 0.9203095 1.0000000 0.920 NA NA
SMO alectinib 0.9213966 1.0000000 0.921 NA NA
MYCN alectinib 1.0000000 1.0000000 1.000 NA NA
MAP2K1 alectinib 1.0000000 1.0000000 1.000 NA NA
FGFR2 alectinib 1.0000000 1.0000000 1.000 NA NA
GATA1 alectinib 1.0000000 1.0000000 1.000 NA NA
PDGFB alectinib 1.0000000 1.0000000 1.000 NA NA
NCOA2 alectinib 1.0000000 1.0000000 1.000 NA NA
PAX8 alectinib 1.0000000 1.0000000 1.000 NA NA
CXCR4 alectinib 1.0000000 1.0000000 1.000 NA NA
ZRSR2 alectinib 1.0000000 1.0000000 1.000 NA NA
IL7R afatinib 0.0140193 1.0000000 0.014
NA
PDGFRB afatinib 0.0323905 1.0000000 0.032
NA
JAK1 afatinib 0.0375635 1.0000000 0.038
NA
MYCN afatinib 0.0661926 1.0000000 0.066 NA NA
EML4 afatinib 0.0691324 1.0000000 0.069 NA NA
PAX5 afatinib 0.0813611 1.0000000 0.081 NA NA
BCORL1 afatinib 0.1295247 1.0000000 0.130 NA NA
GATA3 afatinib 0.1325535 1.0000000 0.133 NA NA
SF1 afatinib 0.1360371 1.0000000 0.136 NA NA
ABL1 afatinib 0.1392493 1.0000000 0.139 NA NA
TP53 afatinib 0.1403919 1.0000000 0.140 NA NA
PTCH1 afatinib 0.1571458 1.0000000 0.157 NA NA
TSC2 afatinib 0.1686855 1.0000000 0.169 NA NA
PTEN afatinib 0.1742555 1.0000000 0.174 NA NA
BRCA1 afatinib 0.1778153 1.0000000 0.178 NA NA
ATM afatinib 0.1897456 1.0000000 0.190 NA NA
EGF afatinib 0.1928758 1.0000000 0.193 NA NA
PRPF40B afatinib 0.2015990 1.0000000 0.202 NA NA
FGFR3 afatinib 0.2045509 1.0000000 0.205 NA NA
CBL afatinib 0.2112995 1.0000000 0.211 NA NA
CSF3R afatinib 0.2293319 1.0000000 0.229 NA NA
GATA1 afatinib 0.2410324 1.0000000 0.241 NA NA
MYD88 afatinib 0.2415666 1.0000000 0.242 NA NA
PDGFB afatinib 0.2415666 1.0000000 0.242 NA NA
AKT2 afatinib 0.2415666 1.0000000 0.242 NA NA
ERBB2 afatinib 0.2704472 1.0000000 0.270 NA NA
EZH2 afatinib 0.2780757 1.0000000 0.278 NA NA
HRAS afatinib 0.2888444 1.0000000 0.289 NA NA
BTK afatinib 0.2986177 1.0000000 0.299 NA NA
ERBB4 afatinib 0.2986380 1.0000000 0.299 NA NA
SETD2 afatinib 0.3079003 1.0000000 0.308 NA NA
RAD21 afatinib 0.3230126 1.0000000 0.323 NA NA
AR afatinib 0.3412685 1.0000000 0.341 NA NA
RET afatinib 0.3463248 1.0000000 0.346 NA NA
CBLB afatinib 0.3525421 1.0000000 0.353 NA NA
ZRSR2 afatinib 0.3593968 1.0000000 0.359 NA NA
XPO1 afatinib 0.3619348 1.0000000 0.362 NA NA
IDH2 afatinib 0.3710934 1.0000000 0.371 NA NA
NRAS afatinib 0.3748016 1.0000000 0.375 NA NA
UGT1A1 afatinib 0.3777807 1.0000000 0.378 NA NA
SETBP1 afatinib 0.3784295 1.0000000 0.378 NA NA
FLT3 afatinib 0.4148455 1.0000000 0.415 NA NA
GATA2 afatinib 0.4167928 1.0000000 0.417 NA NA
NOTCH2 afatinib 0.4257818 1.0000000 0.426 NA NA
CDK4 afatinib 0.4344457 1.0000000 0.434 NA NA
JAK2 afatinib 0.4366607 1.0000000 0.437 NA NA
VHL afatinib 0.4533555 1.0000000 0.453 NA NA
STAT3 afatinib 0.4595426 1.0000000 0.460 NA NA
CTNNB1 afatinib 0.4658564 1.0000000 0.466 NA NA
ASXL1 afatinib 0.4824052 1.0000000 0.482 NA NA
SH2B3 afatinib 0.5402914 1.0000000 0.540 NA NA
CTLA4 afatinib 0.5402914 1.0000000 0.540 NA NA
SF3B1 afatinib 0.5540232 1.0000000 0.554 NA NA
SMC3 afatinib 0.5601197 1.0000000 0.560 NA NA
MAP2K1 afatinib 0.5612758 1.0000000 0.561 NA NA
WT1 afatinib 0.5690882 1.0000000 0.569 NA NA
ESR1 afatinib 0.5790997 1.0000000 0.579 NA NA
MGMT afatinib 0.5958831 1.0000000 0.596 NA NA
EGFR afatinib 0.6119104 1.0000000 0.612 NA NA
GNAS afatinib 0.6172651 1.0000000 0.617 NA NA
BRCA2 afatinib 0.6352378 1.0000000 0.635 NA NA
KRAS afatinib 0.6429328 1.0000000 0.643 NA NA
MPL afatinib 0.6625206 1.0000000 0.663 NA NA
TSC1 afatinib 0.6708487 1.0000000 0.671 NA NA
IKZF1 afatinib 0.6710327 1.0000000 0.671 NA NA
CTCF afatinib 0.7092180 1.0000000 0.709 NA NA
AKT1 afatinib 0.7212767 1.0000000 0.721 NA NA
MET afatinib 0.7266861 1.0000000 0.727 NA NA
NCOA2 afatinib 0.7288260 1.0000000 0.729 NA NA
FGFR1 afatinib 0.7331961 1.0000000 0.733 NA NA
ERBB3 afatinib 0.7411004 1.0000000 0.741 NA NA
NOTCH1 afatinib 0.7593922 1.0000000 0.759 NA NA
PAX8 afatinib 0.7655945 1.0000000 0.766 NA NA
NPM1 afatinib 0.7728300 1.0000000 0.773 NA NA
G6PD afatinib 0.7728300 1.0000000 0.773 NA NA
DDIT3 afatinib 0.7728300 1.0000000 0.773 NA NA
SRSF2 afatinib 0.7728300 1.0000000 0.773 NA NA
ETV6 afatinib 0.7768140 1.0000000 0.777 NA NA
KMT2A afatinib 0.7780324 1.0000000 0.778 NA NA
FGFR2 afatinib 0.7841912 1.0000000 0.784 NA NA
PRPF8 afatinib 0.7878765 1.0000000 0.788 NA NA
WHSC1 afatinib 0.7921474 1.0000000 0.792 NA NA
DNMT3A afatinib 0.7983763 1.0000000 0.798 NA NA
CXCR4 afatinib 0.8025873 1.0000000 0.803 NA NA
AKT3 afatinib 0.8169613 1.0000000 0.817 NA NA
NT5C2 afatinib 0.8169613 1.0000000 0.817 NA NA
STAG2 afatinib 0.8230633 1.0000000 0.823 NA NA
PIK3CA afatinib 0.8326621 1.0000000 0.833 NA NA
PML afatinib 0.8377167 1.0000000 0.838 NA NA
GNA11 afatinib 0.8464506 1.0000000 0.846 NA NA
ROS1 afatinib 0.8610109 1.0000000 0.861 NA NA
GNB1 afatinib 0.8836175 1.0000000 0.884 NA NA
FBXW7 afatinib 0.8857596 1.0000000 0.886 NA NA
DPYD afatinib 0.9118987 1.0000000 0.912 NA NA
BCOR afatinib 0.9184562 1.0000000 0.918 NA NA
CREBBP afatinib 0.9228574 1.0000000 0.923 NA NA
PDGFRA afatinib 0.9405696 1.0000000 0.941 NA NA
ALK afatinib 0.9529231 1.0000000 0.953 NA NA
BRAF afatinib 0.9869873 1.0000000 0.987 NA NA
TET2 afatinib 1.0000000 1.0000000 1.000 NA NA
CALR afatinib 1.0000000 1.0000000 1.000 NA NA
CDKN2A afatinib 1.0000000 1.0000000 1.000 NA NA
IDH1 afatinib 1.0000000 1.0000000 1.000 NA NA
SMO afatinib 1.0000000 1.0000000 1.000 NA NA
KIT afatinib 1.0000000 1.0000000 1.000 NA NA
JAK3 afatinib 1.0000000 1.0000000 1.000 NA NA
SSX1 afatinib 1.0000000 1.0000000 1.000 NA NA
CD79B afatinib 1.0000000 1.0000000 1.000 NA NA
PIGA afatinib 1.0000000 1.0000000 1.000 NA NA
CRLF2 afatinib 1.0000000 1.0000000 1.000 NA NA
SMC1A afatinib 1.0000000 1.0000000 1.000 NA NA
FGFR3 docetaxel 0.0439066 1.0000000 0.044
NA
DNMT3A docetaxel 0.0610279 1.0000000 0.061 NA NA
MYCN docetaxel 0.0661926 1.0000000 0.066 NA NA
FGFR2 docetaxel 0.0828374 1.0000000 0.083 NA NA
PDGFRA docetaxel 0.0863925 1.0000000 0.086 NA NA
AKT3 docetaxel 0.1051925 1.0000000 0.105 NA NA
TSC2 docetaxel 0.1109870 1.0000000 0.111 NA NA
MGMT docetaxel 0.1116118 1.0000000 0.112 NA NA
KMT2A docetaxel 0.1173432 1.0000000 0.117 NA NA
PDGFRB docetaxel 0.1321661 1.0000000 0.132 NA NA
ROS1 docetaxel 0.1486063 1.0000000 0.149 NA NA
CRLF2 docetaxel 0.1489147 1.0000000 0.149 NA NA
GATA3 docetaxel 0.1696541 1.0000000 0.170 NA NA
SMO docetaxel 0.1703249 1.0000000 0.170 NA NA
PAX5 docetaxel 0.1752442 1.0000000 0.175 NA NA
EZH2 docetaxel 0.1930591 1.0000000 0.193 NA NA
IKZF1 docetaxel 0.2025950 1.0000000 0.203 NA NA
STAG2 docetaxel 0.2051177 1.0000000 0.205 NA NA
ZRSR2 docetaxel 0.2217000 1.0000000 0.222 NA NA
DPYD docetaxel 0.2529054 1.0000000 0.253 NA NA
WHSC1 docetaxel 0.2683816 1.0000000 0.268 NA NA
NOTCH1 docetaxel 0.2811908 1.0000000 0.281 NA NA
NOTCH2 docetaxel 0.2976500 1.0000000 0.298 NA NA
ETV6 docetaxel 0.2986177 1.0000000 0.299 NA NA
EML4 docetaxel 0.3126142 1.0000000 0.313 NA NA
XPO1 docetaxel 0.3619348 1.0000000 0.362 NA NA
CTNNB1 docetaxel 0.3658605 1.0000000 0.366 NA NA
IDH2 docetaxel 0.3710934 1.0000000 0.371 NA NA
SF1 docetaxel 0.3710934 1.0000000 0.371 NA NA
PTEN docetaxel 0.3755743 1.0000000 0.376 NA NA
UGT1A1 docetaxel 0.3777807 1.0000000 0.378 NA NA
BCORL1 docetaxel 0.3781105 1.0000000 0.378 NA NA
IDH1 docetaxel 0.3827331 1.0000000 0.383 NA NA
G6PD docetaxel 0.3864762 1.0000000 0.386 NA NA
DDIT3 docetaxel 0.3864762 1.0000000 0.386 NA NA
EGF docetaxel 0.3957657 1.0000000 0.396 NA NA
ABL1 docetaxel 0.4047291 1.0000000 0.405 NA NA
CTCF docetaxel 0.4119913 1.0000000 0.412 NA NA
FLT3 docetaxel 0.4148455 1.0000000 0.415 NA NA
RAD21 docetaxel 0.4291606 1.0000000 0.429 NA NA
CDK4 docetaxel 0.4344457 1.0000000 0.434 NA NA
CBLB docetaxel 0.4468728 1.0000000 0.447 NA NA
CBL docetaxel 0.4532547 1.0000000 0.453 NA NA
ESR1 docetaxel 0.4595426 1.0000000 0.460 NA NA
BRAF docetaxel 0.4831049 1.0000000 0.483 NA NA
CALR docetaxel 0.4874533 1.0000000 0.487 NA NA
NT5C2 docetaxel 0.4874533 1.0000000 0.487 NA NA
CD79B docetaxel 0.4874533 1.0000000 0.487 NA NA
BTK docetaxel 0.5083316 1.0000000 0.508 NA NA
NCOA2 docetaxel 0.5326028 1.0000000 0.533 NA NA
AR docetaxel 0.5406816 1.0000000 0.541 NA NA
SF3B1 docetaxel 0.5540232 1.0000000 0.554 NA NA
AKT2 docetaxel 0.5581846 1.0000000 0.558 NA NA
GNA11 docetaxel 0.5612758 1.0000000 0.561 NA NA
BCOR docetaxel 0.5618168 1.0000000 0.562 NA NA
IL7R docetaxel 0.5707504 1.0000000 0.571 NA NA
PIK3CA docetaxel 0.5827651 1.0000000 0.583 NA NA
TET2 docetaxel 0.5897916 1.0000000 0.590 NA NA
SMC1A docetaxel 0.5958831 1.0000000 0.596 NA NA
ERBB2 docetaxel 0.6212956 1.0000000 0.621 NA NA
ATM docetaxel 0.6294581 1.0000000 0.629 NA NA
PTCH1 docetaxel 0.6372275 1.0000000 0.637 NA NA
VHL docetaxel 0.6527828 1.0000000 0.653 NA NA
MPL docetaxel 0.6625206 1.0000000 0.663 NA NA
JAK3 docetaxel 0.6644424 1.0000000 0.664 NA NA
TSC1 docetaxel 0.6708487 1.0000000 0.671 NA NA
KIT docetaxel 0.6710327 1.0000000 0.671 NA NA
ERBB4 docetaxel 0.6860694 1.0000000 0.686 NA NA
RET docetaxel 0.6865042 1.0000000 0.687 NA NA
CREBBP docetaxel 0.6882920 1.0000000 0.688 NA NA
GATA1 docetaxel 0.6959426 1.0000000 0.696 NA NA
JAK2 docetaxel 0.6973337 1.0000000 0.697 NA NA
GNAS docetaxel 0.7040976 1.0000000 0.704 NA NA
HRAS docetaxel 0.7236736 1.0000000 0.724 NA NA
FGFR1 docetaxel 0.7331961 1.0000000 0.733 NA NA
SETD2 docetaxel 0.7339475 1.0000000 0.734 NA NA
FBXW7 docetaxel 0.7374484 1.0000000 0.737 NA NA
PAX8 docetaxel 0.7655945 1.0000000 0.766 NA NA
ALK docetaxel 0.7678547 1.0000000 0.768 NA NA
SRSF2 docetaxel 0.7728300 1.0000000 0.773 NA NA
PML docetaxel 0.7847867 1.0000000 0.785 NA NA
PRPF8 docetaxel 0.7878765 1.0000000 0.788 NA NA
CDKN2A docetaxel 0.7892058 1.0000000 0.789 NA NA
BRCA1 docetaxel 0.8064547 1.0000000 0.806 NA NA
SETBP1 docetaxel 0.8101625 1.0000000 0.810 NA NA
CSF3R docetaxel 0.8320040 1.0000000 0.832 NA NA
JAK1 docetaxel 0.8500510 1.0000000 0.850 NA NA
ASXL1 docetaxel 0.8882745 1.0000000 0.888 NA NA
EGFR docetaxel 0.8990693 1.0000000 0.899 NA NA
TP53 docetaxel 0.9183676 1.0000000 0.918 NA NA
ERBB3 docetaxel 0.9341703 1.0000000 0.934 NA NA
WT1 docetaxel 0.9351699 1.0000000 0.935 NA NA
BRCA2 docetaxel 0.9459713 1.0000000 0.946 NA NA
SMC3 docetaxel 0.9535364 1.0000000 0.954 NA NA
NRAS docetaxel 0.9692192 1.0000000 0.969 NA NA
KRAS docetaxel 0.9823871 1.0000000 0.982 NA NA
GNB1 docetaxel 1.0000000 1.0000000 1.000 NA NA
STAT3 docetaxel 1.0000000 1.0000000 1.000 NA NA
NPM1 docetaxel 1.0000000 1.0000000 1.000 NA NA
MET docetaxel 1.0000000 1.0000000 1.000 NA NA
MAP2K1 docetaxel 1.0000000 1.0000000 1.000 NA NA
GATA2 docetaxel 1.0000000 1.0000000 1.000 NA NA
MYD88 docetaxel 1.0000000 1.0000000 1.000 NA NA
SSX1 docetaxel 1.0000000 1.0000000 1.000 NA NA
PDGFB docetaxel 1.0000000 1.0000000 1.000 NA NA
PRPF40B docetaxel 1.0000000 1.0000000 1.000 NA NA
SH2B3 docetaxel 1.0000000 1.0000000 1.000 NA NA
PIGA docetaxel 1.0000000 1.0000000 1.000 NA NA
CXCR4 docetaxel 1.0000000 1.0000000 1.000 NA NA
AKT1 docetaxel 1.0000000 1.0000000 1.000 NA NA
CTLA4 docetaxel 1.0000000 1.0000000 1.000 NA NA
SMO vismodegib 0.5979370 1.0000000 0.598 NA NA
ERBB2 vismodegib 0.6212956 1.0000000 0.621 NA NA
PML vismodegib 0.6327203 1.0000000 0.633 NA NA
GNB1 vismodegib 0.6605492 1.0000000 0.661 NA NA
CDK4 vismodegib 0.6959426 1.0000000 0.696 NA NA
GNAS vismodegib 0.7040976 1.0000000 0.704 NA NA
PTCH1 vismodegib 0.7059781 1.0000000 0.706 NA NA
PDGFRA vismodegib 0.7093196 1.0000000 0.709 NA NA
STAT3 vismodegib 0.7115314 1.0000000 0.712 NA NA
SH2B3 vismodegib 0.7133032 1.0000000 0.713 NA NA
ROS1 vismodegib 0.7262074 1.0000000 0.726 NA NA
KMT2A vismodegib 0.7304515 1.0000000 0.730 NA NA
PAX8 vismodegib 0.7655945 1.0000000 0.766 NA NA
PTEN vismodegib 0.7677188 1.0000000 0.768 NA NA
SMC3 vismodegib 0.7707975 1.0000000 0.771 NA NA
CRLF2 vismodegib 0.7728300 1.0000000 0.773 NA NA
KIT vismodegib 0.7770588 1.0000000 0.777 NA NA
EGF vismodegib 0.7771237 1.0000000 0.777 NA NA
ALK vismodegib 0.7904980 1.0000000 0.790 NA NA
CTNNB1 vismodegib 0.7929163 1.0000000 0.793 NA NA
CXCR4 vismodegib 0.8025873 1.0000000 0.803 NA NA
WT1 vismodegib 0.8072104 1.0000000 0.807 NA NA
PDGFRB vismodegib 0.8120916 1.0000000 0.812 NA NA
ASXL1 vismodegib 0.8148713 1.0000000 0.815 NA NA
EGFR vismodegib 0.8325789 1.0000000 0.833 NA NA
AR vismodegib 0.8384101 1.0000000 0.838 NA NA
PAX5 vismodegib 0.8464506 1.0000000 0.846 NA NA
NRAS vismodegib 0.8470075 1.0000000 0.847 NA NA
NOTCH2 vismodegib 0.8541769 1.0000000 0.854 NA NA
SMC1A vismodegib 0.8596838 1.0000000 0.860 NA NA
FGFR3 vismodegib 0.8813501 1.0000000 0.881 NA NA
IKZF1 vismodegib 0.8874141 1.0000000 0.887 NA NA
PRPF8 vismodegib 0.8929799 1.0000000 0.893 NA NA
SETD2 vismodegib 0.9097982 1.0000000 0.910 NA NA
BCORL1 vismodegib 0.9157680 1.0000000 0.916 NA NA
FGFR2 vismodegib 0.9272645 1.0000000 0.927 NA NA
MET vismodegib 0.9746506 1.0000000 0.975 NA NA
IDH2 vismodegib 1.0000000 1.0000000 1.000 NA NA
MYCN vismodegib 1.0000000 1.0000000 1.000 NA NA
MGMT vismodegib 1.0000000 1.0000000 1.000 NA NA
CALR vismodegib 1.0000000 1.0000000 1.000 NA NA
GATA1 vismodegib 1.0000000 1.0000000 1.000 NA NA
SF1 vismodegib 1.0000000 1.0000000 1.000 NA NA
CD79B vismodegib 1.0000000 1.0000000 1.000 NA NA
PIGA vismodegib 1.0000000 1.0000000 1.000 NA NA
AKT1 vismodegib 1.0000000 1.0000000 1.000 NA NA
PDGFRB tretinoin 0.1179267 1.0000000 0.1179 NA NA
TP53 tretinoin 0.1306260 1.0000000 0.1306 NA NA
G6PD tretinoin 0.1489147 1.0000000 0.1489 NA NA
BTK tretinoin 0.1563757 1.0000000 0.1564 NA NA
IDH1 tretinoin 0.1904303 1.0000000 0.1904 NA NA
BRCA1 tretinoin 0.2205710 1.0000000 0.2206 NA NA
GATA1 tretinoin 0.2410324 1.0000000 0.2410 NA NA
JAK2 tretinoin 0.2433046 1.0000000 0.2433 NA NA
AKT3 tretinoin 0.2471600 1.0000000 0.2472 NA NA
NT5C2 tretinoin 0.2471600 1.0000000 0.2472 NA NA
DPYD tretinoin 0.2529054 1.0000000 0.2529 NA NA
SETD2 tretinoin 0.2572433 1.0000000 0.2572 NA NA
IKZF1 tretinoin 0.2573755 1.0000000 0.2574 NA NA
PTEN tretinoin 0.2758896 1.0000000 0.2759 NA NA
HRAS tretinoin 0.2888444 1.0000000 0.2888 NA NA
AKT2 tretinoin 0.2888444 1.0000000 0.2888 NA NA
SMC3 tretinoin 0.2942726 1.0000000 0.2943 NA NA
FGFR1 tretinoin 0.3064822 1.0000000 0.3065 NA NA
DNMT3A tretinoin 0.3068773 1.0000000 0.3069 NA NA
FBXW7 tretinoin 0.3145586 1.0000000 0.3146 NA NA
CTCF tretinoin 0.3322673 1.0000000 0.3323 NA NA
PAX5 tretinoin 0.3329216 1.0000000 0.3329 NA NA
NOTCH1 tretinoin 0.3349399 1.0000000 0.3349 NA NA
TSC2 tretinoin 0.3543585 1.0000000 0.3544 NA NA
STAT3 tretinoin 0.3552259 1.0000000 0.3552 NA NA
WHSC1 tretinoin 0.3647740 1.0000000 0.3648 NA NA
SSX1 tretinoin 0.3710934 1.0000000 0.3711 NA NA
DDIT3 tretinoin 0.3864762 1.0000000 0.3865 NA NA
GATA3 tretinoin 0.3952428 1.0000000 0.3952 NA NA
ROS1 tretinoin 0.4424632 1.0000000 0.4425 NA NA
PML tretinoin 0.4526598 1.0000000 0.4527 NA NA
CBL tretinoin 0.4532547 1.0000000 0.4533 NA NA
FGFR3 tretinoin 0.4577319 1.0000000 0.4577 NA NA
WT1 tretinoin 0.4641203 1.0000000 0.4641 NA NA
ATM tretinoin 0.4763120 1.0000000 0.4763 NA NA
FGFR2 tretinoin 0.4896603 1.0000000 0.4897 NA NA
AR tretinoin 0.4966574 1.0000000 0.4967 NA NA
ERBB3 tretinoin 0.5125322 1.0000000 0.5125 NA NA
BCOR tretinoin 0.5167279 1.0000000 0.5167 NA NA
SMO tretinoin 0.5268359 1.0000000 0.5268 NA NA
EGF tretinoin 0.5334473 1.0000000 0.5334 NA NA
CTLA4 tretinoin 0.5402914 1.0000000 0.5403 NA NA
PTCH1 tretinoin 0.5415255 1.0000000 0.5415 NA NA
BRCA2 tretinoin 0.5419273 1.0000000 0.5419 NA NA
CREBBP tretinoin 0.5427437 1.0000000 0.5427 NA NA
BCORL1 tretinoin 0.5489458 1.0000000 0.5489 NA NA
UGT1A1 tretinoin 0.5565355 1.0000000 0.5565 NA NA
PDGFB tretinoin 0.5581846 1.0000000 0.5582 NA NA
MAP2K1 tretinoin 0.5612758 1.0000000 0.5613 NA NA
JAK3 tretinoin 0.5630049 1.0000000 0.5630 NA NA
PRPF40B tretinoin 0.5703340 1.0000000 0.5703 NA NA
IL7R tretinoin 0.5707504 1.0000000 0.5708 NA NA
PDGFRA tretinoin 0.6017552 1.0000000 0.6018 NA NA
ABL1 tretinoin 0.6064676 1.0000000 0.6065 NA NA
CTNNB1 tretinoin 0.6199780 1.0000000 0.6200 NA NA
PIGA tretinoin 0.6373519 1.0000000 0.6374 NA NA
NRAS tretinoin 0.6454372 1.0000000 0.6454 NA NA
BRAF tretinoin 0.6596748 1.0000000 0.6597 NA NA
PIK3CA tretinoin 0.6649072 1.0000000 0.6649 NA NA
RET tretinoin 0.6865042 1.0000000 0.6865 NA NA
CRLF2 tretinoin 0.6985354 1.0000000 0.6985 NA NA
MYCN tretinoin 0.7133032 1.0000000 0.7133 NA NA
SH2B3 tretinoin 0.7133032 1.0000000 0.7133 NA NA
AKT1 tretinoin 0.7212767 1.0000000 0.7213 NA NA
CALR tretinoin 0.7236736 1.0000000 0.7237 NA NA
CD79B tretinoin 0.7236736 1.0000000 0.7237 NA NA
MET tretinoin 0.7266861 1.0000000 0.7267 NA NA
GNAS tretinoin 0.7339947 1.0000000 0.7340 NA NA
EGFR tretinoin 0.7351882 1.0000000 0.7352 NA NA
NPM1 tretinoin 0.7728300 1.0000000 0.7728 NA NA
SRSF2 tretinoin 0.7728300 1.0000000 0.7728 NA NA
ERBB4 tretinoin 0.7871837 1.0000000 0.7872 NA NA
ERBB2 tretinoin 0.7902330 1.0000000 0.7902 NA NA
CBLB tretinoin 0.7998461 1.0000000 0.7998 NA NA
CXCR4 tretinoin 0.8025873 1.0000000 0.8026 NA NA
SETBP1 tretinoin 0.8101625 1.0000000 0.8102 NA NA
ASXL1 tretinoin 0.8148713 1.0000000 0.8149 NA NA
STAG2 tretinoin 0.8230633 1.0000000 0.8231 NA NA
EZH2 tretinoin 0.8282625 1.0000000 0.8283 NA NA
RAD21 tretinoin 0.8433133 1.0000000 0.8433 NA NA
GNA11 tretinoin 0.8464506 1.0000000 0.8465 NA NA
SMC1A tretinoin 0.8596838 1.0000000 0.8597 NA NA
VHL tretinoin 0.8807910 1.0000000 0.8808 NA NA
CDKN2A tretinoin 0.8860723 1.0000000 0.8861 NA NA
TET2 tretinoin 0.9522319 1.0000000 0.9522 NA NA
IDH2 tretinoin 1.0000000 1.0000000 1.0000 NA NA
MGMT tretinoin 1.0000000 1.0000000 1.0000 NA NA
GNB1 tretinoin 1.0000000 1.0000000 1.0000 NA NA
TSC1 tretinoin 1.0000000 1.0000000 1.0000 NA NA
PRPF8 tretinoin 1.0000000 1.0000000 1.0000 NA NA
SF3B1 tretinoin 1.0000000 1.0000000 1.0000 NA NA
ETV6 tretinoin 1.0000000 1.0000000 1.0000 NA NA
KMT2A tretinoin 1.0000000 1.0000000 1.0000 NA NA
KIT tretinoin 1.0000000 1.0000000 1.0000 NA NA
MYD88 tretinoin 1.0000000 1.0000000 1.0000 NA NA
SF1 tretinoin 1.0000000 1.0000000 1.0000 NA NA
NCOA2 tretinoin 1.0000000 1.0000000 1.0000 NA NA
PAX8 tretinoin 1.0000000 1.0000000 1.0000 NA NA
ESR1 tretinoin 1.0000000 1.0000000 1.0000 NA NA
MPL tretinoin 1.0000000 1.0000000 1.0000 NA NA
CDK4 tretinoin 1.0000000 1.0000000 1.0000 NA NA
SMO bosutinib monohydrate 0.9159998 1.0000000 0.916 NA NA
PDGFRA bosutinib monohydrate 0.9405696 1.0000000 0.941 NA NA
EGF bosutinib monohydrate 0.9548528 1.0000000 0.955 NA NA
ROS1 bosutinib monohydrate 0.9650862 1.0000000 0.965 NA NA
NPM1 bosutinib monohydrate 1.0000000 1.0000000 1.000 NA NA
NT5C2 bosutinib monohydrate 1.0000000 1.0000000 1.000 NA NA
SF3B1 bosutinib monohydrate 1.0000000 1.0000000 1.000 NA NA
WT1 bosutinib monohydrate 1.0000000 1.0000000 1.000 NA NA
PAX8 bosutinib monohydrate 1.0000000 1.0000000 1.000 NA NA
CD79B bosutinib monohydrate 1.0000000 1.0000000 1.000 NA NA
AKT2 bosutinib monohydrate 1.0000000 1.0000000 1.000 NA NA
PIK3CA nilotinib 0.3254032 1.0000000 0.325 NA NA
ETV6 nilotinib 0.3373557 1.0000000 0.337 NA NA
SMC1A nilotinib 0.3767591 1.0000000 0.377 NA NA
BCORL1 nilotinib 0.3781105 1.0000000 0.378 NA NA
MPL nilotinib 0.3827331 1.0000000 0.383 NA NA
G6PD nilotinib 0.3864762 1.0000000 0.386 NA NA
ZRSR2 nilotinib 0.3864762 1.0000000 0.386 NA NA
XPO1 nilotinib 0.4046568 1.0000000 0.405 NA NA
RET nilotinib 0.4362749 1.0000000 0.436 NA NA
BCOR nilotinib 0.4470053 1.0000000 0.447 NA NA
SMO nilotinib 0.4603216 1.0000000 0.460 NA NA
NRAS nilotinib 0.4634580 1.0000000 0.463 NA NA
AKT3 nilotinib 0.4874533 1.0000000 0.487 NA NA
GNA11 nilotinib 0.4874533 1.0000000 0.487 NA NA
SETD2 nilotinib 0.4926027 1.0000000 0.493 NA NA
KIT nilotinib 0.4983717 1.0000000 0.498 NA NA
ALK nilotinib 0.5324420 1.0000000 0.532 NA NA
DDIT3 nilotinib 0.5402914 1.0000000 0.540 NA NA
CTLA4 nilotinib 0.5402914 1.0000000 0.540 NA NA
ATM nilotinib 0.5426643 1.0000000 0.543 NA NA
TET2 nilotinib 0.5499800 1.0000000 0.550 NA NA
CSF3R nilotinib 0.5541131 1.0000000 0.554 NA NA
UGT1A1 nilotinib 0.5565355 1.0000000 0.557 NA NA
PDGFB nilotinib 0.5581846 1.0000000 0.558 NA NA
PAX5 nilotinib 0.5612758 1.0000000 0.561 NA NA
MAP2K1 nilotinib 0.5612758 1.0000000 0.561 NA NA
WHSC1 nilotinib 0.5620826 1.0000000 0.562 NA NA
PDGFRB nilotinib 0.5686182 1.0000000 0.569 NA NA
FGFR3 nilotinib 0.6063626 1.0000000 0.606 NA NA
SF3B1 nilotinib 0.6101655 1.0000000 0.610 NA NA
EGFR nilotinib 0.6282405 1.0000000 0.628 NA NA
PTEN nilotinib 0.6336810 1.0000000 0.634 NA NA
PIGA nilotinib 0.6373519 1.0000000 0.637 NA NA
CTNNB1 nilotinib 0.6586643 1.0000000 0.659 NA NA
GNB1 nilotinib 0.6605492 1.0000000 0.661 NA NA
SH2B3 nilotinib 0.6650055 1.0000000 0.665 NA NA
ERBB3 nilotinib 0.6796099 1.0000000 0.680 NA NA
ROS1 nilotinib 0.6992900 1.0000000 0.699 NA NA
BRCA1 nilotinib 0.7090407 1.0000000 0.709 NA NA
PML nilotinib 0.7212961 1.0000000 0.721 NA NA
NT5C2 nilotinib 0.7236736 1.0000000 0.724 NA NA
MYD88 nilotinib 0.7236736 1.0000000 0.724 NA NA
CXCR4 nilotinib 0.7236736 1.0000000 0.724 NA NA
EZH2 nilotinib 0.7284542 1.0000000 0.728 NA NA
NCOA2 nilotinib 0.7287085 1.0000000 0.729 NA NA
FBXW7 nilotinib 0.7369822 1.0000000 0.737 NA NA
FGFR2 nilotinib 0.7472620 1.0000000 0.747 NA NA
NPM1 nilotinib 0.7728300 1.0000000 0.773 NA NA
CD79B nilotinib 0.7728300 1.0000000 0.773 NA NA
ERBB2 nilotinib 0.7902330 1.0000000 0.790 NA NA
CBLB nilotinib 0.7998461 1.0000000 0.800 NA NA
CALR nilotinib 0.8169613 1.0000000 0.817 NA NA
VHL nilotinib 0.8169613 1.0000000 0.817 NA NA
STAT3 nilotinib 0.8197075 1.0000000 0.820 NA NA
GATA3 nilotinib 0.8444630 1.0000000 0.844 NA NA
ESR1 nilotinib 0.8533074 1.0000000 0.853 NA NA
EGF nilotinib 0.8651347 1.0000000 0.865 NA NA
GATA2 nilotinib 0.8709912 1.0000000 0.871 NA NA
DPYD nilotinib 0.9069783 1.0000000 0.907 NA NA
TSC1 nilotinib 0.9144580 1.0000000 0.914 NA NA
WT1 nilotinib 0.9351699 1.0000000 0.935 NA NA
MET nilotinib 0.9378870 1.0000000 0.938 NA NA
CDKN2A nilotinib 0.9724174 1.0000000 0.972 NA NA
IDH2 nilotinib 1.0000000 1.0000000 1.000 NA NA
MYCN nilotinib 1.0000000 1.0000000 1.000 NA NA
IKZF1 nilotinib 1.0000000 1.0000000 1.000 NA NA
AR nilotinib 1.0000000 1.0000000 1.000 NA NA
KRAS nilotinib 1.0000000 1.0000000 1.000 NA NA
SETBP1 nilotinib 1.0000000 1.0000000 1.000 NA NA
JAK3 nilotinib 1.0000000 1.0000000 1.000 NA NA
GATA1 nilotinib 1.0000000 1.0000000 1.000 NA NA
SF1 nilotinib 1.0000000 1.0000000 1.000 NA NA
PAX8 nilotinib 1.0000000 1.0000000 1.000 NA NA
PRPF40B nilotinib 1.0000000 1.0000000 1.000 NA NA
ASXL1 nilotinib 1.0000000 1.0000000 1.000 NA NA
CDK4 nilotinib 1.0000000 1.0000000 1.000 NA NA
AKT2 nilotinib 1.0000000 1.0000000 1.000 NA NA
SETBP1 trametinib 0.0631425 1.0000000 0.063 NA NA
PIK3CA trametinib 0.1161003 1.0000000 0.116 NA NA
FGFR2 trametinib 0.1206908 1.0000000 0.121 NA NA
NCOA2 trametinib 0.1358334 1.0000000 0.136 NA NA
CBLB trametinib 0.1390867 1.0000000 0.139 NA NA
SMO trametinib 0.1397736 1.0000000 0.140 NA NA
ERBB2 trametinib 0.1602162 1.0000000 0.160 NA NA
GNB1 trametinib 0.1714602 1.0000000 0.171 NA NA
CBL trametinib 0.1904303 1.0000000 0.190 NA NA
STAG2 trametinib 0.1930591 1.0000000 0.193 NA NA
CTCF trametinib 0.2048400 1.0000000 0.205 NA NA
FGFR1 trametinib 0.2157783 1.0000000 0.216 NA NA
MGMT trametinib 0.2330380 1.0000000 0.233 NA NA
PDGFB trametinib 0.2415666 1.0000000 0.242 NA NA
AKT3 trametinib 0.2415666 1.0000000 0.242 NA NA
CTLA4 trametinib 0.2452781 1.0000000 0.245 NA NA
BRCA1 trametinib 0.2664388 1.0000000 0.266 NA NA
NOTCH1 trametinib 0.2691595 1.0000000 0.269 NA NA
GATA1 trametinib 0.2723606 1.0000000 0.272 NA NA
KMT2A trametinib 0.2831345 1.0000000 0.283 NA NA
AR trametinib 0.3103990 1.0000000 0.310 NA NA
EML4 trametinib 0.3140923 1.0000000 0.314 NA NA
ATM trametinib 0.3337484 1.0000000 0.334 NA NA
RAD21 trametinib 0.3416822 1.0000000 0.342 NA NA
TET2 trametinib 0.3442850 1.0000000 0.344 NA NA
BTK trametinib 0.3502376 1.0000000 0.350 NA NA
ZRSR2 trametinib 0.3593968 1.0000000 0.359 NA NA
SF1 trametinib 0.3619348 1.0000000 0.362 NA NA
CDK6 trametinib 0.3710934 1.0000000 0.371 NA NA
MET trametinib 0.3737145 1.0000000 0.374 NA NA
DPYD trametinib 0.3737145 1.0000000 0.374 NA NA
SMC3 trametinib 0.3821206 1.0000000 0.382 NA NA
IDH1 trametinib 0.3827331 1.0000000 0.383 NA NA
IKZF1 trametinib 0.3912838 1.0000000 0.391 NA NA
BCOR trametinib 0.4038311 1.0000000 0.404 NA NA
PML trametinib 0.4072673 1.0000000 0.407 NA NA
EGF trametinib 0.4291953 1.0000000 0.429 NA NA
BRAF trametinib 0.4374152 1.0000000 0.437 NA NA
XPO1 trametinib 0.4446962 1.0000000 0.445 NA NA
DNAJB1 trametinib 0.4532547 1.0000000 0.453 NA NA
ALK trametinib 0.4662913 1.0000000 0.466 NA NA
NPM1 trametinib 0.4874533 1.0000000 0.487 NA NA
NT5C2 trametinib 0.4874533 1.0000000 0.487 NA NA
G6PD trametinib 0.4874533 1.0000000 0.487 NA NA
HRAS trametinib 0.4874533 1.0000000 0.487 NA NA
CDK4 trametinib 0.5024303 1.0000000 0.502 NA NA
GNAS trametinib 0.5272297 1.0000000 0.527 NA NA
MYCN trametinib 0.5402914 1.0000000 0.540 NA NA
TSC2 trametinib 0.5461873 1.0000000 0.546 NA NA
ASXL1 trametinib 0.5489458 1.0000000 0.549 NA NA
MYD88 trametinib 0.5581846 1.0000000 0.558 NA NA
RUNX1 trametinib 0.5612758 1.0000000 0.561 NA NA
MAP2K1 trametinib 0.5612758 1.0000000 0.561 NA NA
VHL trametinib 0.5676354 1.0000000 0.568 NA NA
DNMT3A trametinib 0.5700925 1.0000000 0.570 NA NA
FLT3 trametinib 0.6017552 1.0000000 0.602 NA NA
ROS1 trametinib 0.6065156 1.0000000 0.607 NA NA
ERBB4 trametinib 0.6170396 1.0000000 0.617 NA NA
MPL trametinib 0.6352563 1.0000000 0.635 NA NA
WHSC1 trametinib 0.6394022 1.0000000 0.639 NA NA
UGT1A1 trametinib 0.6464996 1.0000000 0.646 NA NA
IL7R trametinib 0.6592430 1.0000000 0.659 NA NA
SMC1A trametinib 0.6650055 1.0000000 0.665 NA NA
TSC1 trametinib 0.6708487 1.0000000 0.671 NA NA
ABL1 trametinib 0.6723358 1.0000000 0.672 NA NA
EZH2 trametinib 0.7093881 1.0000000 0.709 NA NA
PDGFRB trametinib 0.7121354 1.0000000 0.712 NA NA
RET trametinib 0.7121781 1.0000000 0.712 NA NA
KIT trametinib 0.7130582 1.0000000 0.713 NA NA
FBXW7 trametinib 0.7145130 1.0000000 0.715 NA NA
JAK3 trametinib 0.7336372 1.0000000 0.734 NA NA
PTCH1 trametinib 0.7342064 1.0000000 0.734 NA NA
PAX8 trametinib 0.7491191 1.0000000 0.749 NA NA
SRSF2 trametinib 0.7728300 1.0000000 0.773 NA NA
ETV6 trametinib 0.7989067 1.0000000 0.799 NA NA
STAT3 trametinib 0.7998461 1.0000000 0.800 NA NA
ESR1 trametinib 0.7998461 1.0000000 0.800 NA NA
JAK1 trametinib 0.8012974 1.0000000 0.801 NA NA
NRAS trametinib 0.8020445 1.0000000 0.802 NA NA
FGFR3 trametinib 0.8050729 1.0000000 0.805 NA NA
NOTCH2 trametinib 0.8156757 1.0000000 0.816 NA NA
CALR trametinib 0.8169613 1.0000000 0.817 NA NA
PAX5 trametinib 0.8197075 1.0000000 0.820 NA NA
TP53 trametinib 0.8228175 1.0000000 0.823 NA NA
CREBBP trametinib 0.8358316 1.0000000 0.836 NA NA
PRPF8 trametinib 0.8414119 1.0000000 0.841 NA NA
AKT2 trametinib 0.8464506 1.0000000 0.846 NA NA
EGFR trametinib 0.8542914 1.0000000 0.854 NA NA
BRCA2 trametinib 0.8856044 1.0000000 0.886 NA NA
BCORL1 trametinib 0.8886105 1.0000000 0.889 NA NA
CDKN2A trametinib 0.8936624 1.0000000 0.894 NA NA
PRPF40B trametinib 0.9032663 1.0000000 0.903 NA NA
ERBB3 trametinib 0.9341703 1.0000000 0.934 NA NA
SH2B3 trametinib 0.9361863 1.0000000 0.936 NA NA
CSF3R trametinib 0.9511703 1.0000000 0.951 NA NA
KRAS trametinib 0.9820637 1.0000000 0.982 NA NA
IDH2 trametinib 1.0000000 1.0000000 1.000 NA NA
PDGFRA trametinib 1.0000000 1.0000000 1.000 NA NA
CRLF2 trametinib 1.0000000 1.0000000 1.000 NA NA
SETD2 trametinib 1.0000000 1.0000000 1.000 NA NA
GNA11 trametinib 1.0000000 1.0000000 1.000 NA NA
CD79B trametinib 1.0000000 1.0000000 1.000 NA NA
PIGA trametinib 1.0000000 1.0000000 1.000 NA NA
CXCR4 trametinib 1.0000000 1.0000000 1.000 NA NA
DDIT3 trametinib 1.0000000 1.0000000 1.000 NA NA
JAK2 trametinib 1.0000000 1.0000000 1.000 NA NA
AKT1 trametinib 1.0000000 1.0000000 1.000 NA NA
PDGFRB midostaurin 0.0097966 1.0000000 0.0098 ** NA
ETV6 midostaurin 0.0283773 1.0000000 0.0284
NA
ERBB3 midostaurin 0.0742813 1.0000000 0.0743 NA NA
TSC2 midostaurin 0.0822765 1.0000000 0.0823 NA NA
EGF midostaurin 0.1152906 1.0000000 0.1153 NA NA
KIT midostaurin 0.1168579 1.0000000 0.1169 NA NA
STAG2 midostaurin 0.1206908 1.0000000 0.1207 NA NA
PTCH1 midostaurin 0.1298475 1.0000000 0.1298 NA NA
IL7R midostaurin 0.1312104 1.0000000 0.1312 NA NA
SETD2 midostaurin 0.1382390 1.0000000 0.1382 NA NA
DDIT3 midostaurin 0.1489147 1.0000000 0.1489 NA NA
FGFR3 midostaurin 0.1512811 1.0000000 0.1513 NA NA
VHL midostaurin 0.1521073 1.0000000 0.1521 NA NA
AKT3 midostaurin 0.1752442 1.0000000 0.1752 NA NA
IDH1 midostaurin 0.1876828 1.0000000 0.1877 NA NA
CXCR4 midostaurin 0.2112995 1.0000000 0.2113 NA NA
GNAS midostaurin 0.2193678 1.0000000 0.2194 NA NA
JAK2 midostaurin 0.2216120 1.0000000 0.2216 NA NA
ERBB2 midostaurin 0.2222590 1.0000000 0.2223 NA NA
PML midostaurin 0.2328442 1.0000000 0.2328 NA NA
CALR midostaurin 0.2471600 1.0000000 0.2472 NA NA
JAK1 midostaurin 0.2532459 1.0000000 0.2532 NA NA
MYD88 midostaurin 0.2888444 1.0000000 0.2888 NA NA
MAP2K1 midostaurin 0.2962699 1.0000000 0.2963 NA NA
ROS1 midostaurin 0.3064280 1.0000000 0.3064 NA NA
SH2B3 midostaurin 0.3153025 1.0000000 0.3153 NA NA
CSF3R midostaurin 0.3502376 1.0000000 0.3502 NA NA
STAT3 midostaurin 0.3525421 1.0000000 0.3525 NA NA
PRPF8 midostaurin 0.3679101 1.0000000 0.3679 NA NA
ATM midostaurin 0.3684968 1.0000000 0.3685 NA NA
NRAS midostaurin 0.3687105 1.0000000 0.3687 NA NA
IDH2 midostaurin 0.3710934 1.0000000 0.3711 NA NA
NCOA2 midostaurin 0.3746505 1.0000000 0.3747 NA NA
GATA1 midostaurin 0.3777807 1.0000000 0.3778 NA NA
NT5C2 midostaurin 0.3864762 1.0000000 0.3865 NA NA
GNA11 midostaurin 0.3864762 1.0000000 0.3865 NA NA
SRSF2 midostaurin 0.3864762 1.0000000 0.3865 NA NA
WT1 midostaurin 0.3907143 1.0000000 0.3907 NA NA
FGFR2 midostaurin 0.4128303 1.0000000 0.4128 NA NA
FLT3 midostaurin 0.4171891 1.0000000 0.4172 NA NA
DNMT3A midostaurin 0.4171891 1.0000000 0.4172 NA NA
ALK midostaurin 0.4270694 1.0000000 0.4271 NA NA
RUNX1 midostaurin 0.4291953 1.0000000 0.4292 NA NA
NOTCH1 midostaurin 0.4329265 1.0000000 0.4329 NA NA
AKT1 midostaurin 0.4605582 1.0000000 0.4606 NA NA
EZH2 midostaurin 0.4650038 1.0000000 0.4650 NA NA
TET2 midostaurin 0.4704864 1.0000000 0.4705 NA NA
BRCA2 midostaurin 0.4765591 1.0000000 0.4766 NA NA
BCOR midostaurin 0.4847907 1.0000000 0.4848 NA NA
G6PD midostaurin 0.4874533 1.0000000 0.4875 NA NA
PAX5 midostaurin 0.4941245 1.0000000 0.4941 NA NA
FGFR1 midostaurin 0.5160638 1.0000000 0.5161 NA NA
RAD21 midostaurin 0.5185170 1.0000000 0.5185 NA NA
SF1 midostaurin 0.5186050 1.0000000 0.5186 NA NA
CTLA4 midostaurin 0.5402914 1.0000000 0.5403 NA NA
ERBB4 midostaurin 0.5623068 1.0000000 0.5623 NA NA
FBXW7 midostaurin 0.5701297 1.0000000 0.5701 NA NA
CBLB midostaurin 0.5790997 1.0000000 0.5791 NA NA
ABL1 midostaurin 0.5995102 1.0000000 0.5995 NA NA
MET midostaurin 0.6238073 1.0000000 0.6238 NA NA
TP53 midostaurin 0.6469162 1.0000000 0.6469 NA NA
CD79B midostaurin 0.6625206 1.0000000 0.6625 NA NA
SMC1A midostaurin 0.6650055 1.0000000 0.6650 NA NA
CTCF midostaurin 0.6708487 1.0000000 0.6708 NA NA
CTNNB1 midostaurin 0.6961716 1.0000000 0.6962 NA NA
PDGFRA midostaurin 0.7070567 1.0000000 0.7071 NA NA
ASXL1 midostaurin 0.7268003 1.0000000 0.7268 NA NA
SMC3 midostaurin 0.7340460 1.0000000 0.7340 NA NA
CDK4 midostaurin 0.7373721 1.0000000 0.7374 NA NA
PAX8 midostaurin 0.7491191 1.0000000 0.7491 NA NA
KMT2A midostaurin 0.7501271 1.0000000 0.7501 NA NA
XPO1 midostaurin 0.7768140 1.0000000 0.7768 NA NA
CREBBP midostaurin 0.7908790 1.0000000 0.7909 NA NA
DNAJB1 midostaurin 0.8025873 1.0000000 0.8026 NA NA
EGFR midostaurin 0.8071948 1.0000000 0.8072 NA NA
GATA2 midostaurin 0.8262002 1.0000000 0.8262 NA NA
SMO midostaurin 0.8435541 1.0000000 0.8436 NA NA
BRAF midostaurin 0.8461246 1.0000000 0.8461 NA NA
MGMT midostaurin 0.8464506 1.0000000 0.8465 NA NA
PRPF40B midostaurin 0.8759990 1.0000000 0.8760 NA NA
NOTCH2 midostaurin 0.9024811 1.0000000 0.9025 NA NA
DPYD midostaurin 0.9031158 1.0000000 0.9031 NA NA
PTEN midostaurin 0.9059535 1.0000000 0.9060 NA NA
WHSC1 midostaurin 0.9159998 1.0000000 0.9160 NA NA
UGT1A1 midostaurin 0.9243755 1.0000000 0.9244 NA NA
TSC1 midostaurin 0.9322640 1.0000000 0.9323 NA NA
BTK midostaurin 0.9323244 1.0000000 0.9323 NA NA
SETBP1 midostaurin 0.9412443 1.0000000 0.9412 NA NA
CDKN2A midostaurin 0.9414999 1.0000000 0.9415 NA NA
RET midostaurin 0.9579673 1.0000000 0.9580 NA NA
SF3B1 midostaurin 0.9702439 1.0000000 0.9702 NA NA
AR midostaurin 0.9716299 1.0000000 0.9716 NA NA
KRAS midostaurin 0.9826990 1.0000000 0.9827 NA NA
MYCN midostaurin 1.0000000 1.0000000 1.0000 NA NA
IKZF1 midostaurin 1.0000000 1.0000000 1.0000 NA NA
GNB1 midostaurin 1.0000000 1.0000000 1.0000 NA NA
NPM1 midostaurin 1.0000000 1.0000000 1.0000 NA NA
BCORL1 midostaurin 1.0000000 1.0000000 1.0000 NA NA
GATA3 midostaurin 1.0000000 1.0000000 1.0000 NA NA
JAK3 midostaurin 1.0000000 1.0000000 1.0000 NA NA
BRCA1 midostaurin 1.0000000 1.0000000 1.0000 NA NA
EML4 midostaurin 1.0000000 1.0000000 1.0000 NA NA
CRLF2 midostaurin 1.0000000 1.0000000 1.0000 NA NA
SSX1 midostaurin 1.0000000 1.0000000 1.0000 NA NA
ESR1 midostaurin 1.0000000 1.0000000 1.0000 NA NA
PDGFB midostaurin 1.0000000 1.0000000 1.0000 NA NA
AKT2 midostaurin 1.0000000 1.0000000 1.0000 NA NA
CBL midostaurin 1.0000000 1.0000000 1.0000 NA NA
ZRSR2 midostaurin 1.0000000 1.0000000 1.0000 NA NA
HRAS midostaurin 1.0000000 1.0000000 1.0000 NA NA
CDK6 midostaurin 1.0000000 1.0000000 1.0000 NA NA
XPO1 pazopanib 0.9247190 1.0000000 0.925 NA NA
FBXW7 pazopanib 0.9271927 1.0000000 0.927 NA NA
PTEN pazopanib 0.9517309 1.0000000 0.952 NA NA
IDH2 pazopanib 1.0000000 1.0000000 1.000 NA NA
ERBB2 pazopanib 1.0000000 1.0000000 1.000 NA NA
STAT3 pazopanib 1.0000000 1.0000000 1.000 NA NA
ERBB4 pazopanib 1.0000000 1.0000000 1.000 NA NA
RAD21 pazopanib 1.0000000 1.0000000 1.000 NA NA
EGFR pazopanib 1.0000000 1.0000000 1.000 NA NA
ESR1 pazopanib 1.0000000 1.0000000 1.000 NA NA
GNA11 pazopanib 1.0000000 1.0000000 1.000 NA NA
HRAS pazopanib 1.0000000 1.0000000 1.000 NA NA
RET ponatinib 0.4291953 1.0000000 0.429 NA NA
ETV6 ponatinib 0.4366766 1.0000000 0.437 NA NA
STAT3 ponatinib 0.4468728 1.0000000 0.447 NA NA
G6PD ponatinib 0.4874533 1.0000000 0.487 NA NA
XPO1 ponatinib 0.5083316 1.0000000 0.508 NA NA
FGFR1 ponatinib 0.5160638 1.0000000 0.516 NA NA
VHL ponatinib 0.5393680 1.0000000 0.539 NA NA
CTLA4 ponatinib 0.5402914 1.0000000 0.540 NA NA
IKZF1 ponatinib 0.5439933 1.0000000 0.544 NA NA
PDGFB ponatinib 0.5581846 1.0000000 0.558 NA NA
AKT3 ponatinib 0.5612758 1.0000000 0.561 NA NA
ERBB4 ponatinib 0.5623068 1.0000000 0.562 NA NA
GNAS ponatinib 0.6057116 1.0000000 0.606 NA NA
ESR1 ponatinib 0.6098340 1.0000000 0.610 NA NA
SF3B1 ponatinib 0.6277256 1.0000000 0.628 NA NA
RUNX1 ponatinib 0.6352563 1.0000000 0.635 NA NA
CD79B ponatinib 0.6625206 1.0000000 0.663 NA NA
TET2 ponatinib 0.6650055 1.0000000 0.665 NA NA
WT1 ponatinib 0.6678058 1.0000000 0.668 NA NA
AR ponatinib 0.6956454 1.0000000 0.696 NA NA
SF1 ponatinib 0.6985354 1.0000000 0.699 NA NA
ABL1 ponatinib 0.7001804 1.0000000 0.700 NA NA
BRAF ponatinib 0.7089975 1.0000000 0.709 NA NA
MYD88 ponatinib 0.7236736 1.0000000 0.724 NA NA
HRAS ponatinib 0.7236736 1.0000000 0.724 NA NA
KMT2A ponatinib 0.7292187 1.0000000 0.729 NA NA
EML4 ponatinib 0.7372047 1.0000000 0.737 NA NA
CDK4 ponatinib 0.7373721 1.0000000 0.737 NA NA
PDGFRA ponatinib 0.7504890 1.0000000 0.750 NA NA
PRPF40B ponatinib 0.7549750 1.0000000 0.755 NA NA
GATA1 ponatinib 0.7687598 1.0000000 0.769 NA NA
DDIT3 ponatinib 0.7728300 1.0000000 0.773 NA NA
SRSF2 ponatinib 0.7728300 1.0000000 0.773 NA NA
NCOA2 ponatinib 0.7940027 1.0000000 0.794 NA NA
CXCR4 ponatinib 0.8025873 1.0000000 0.803 NA NA
DNAJB1 ponatinib 0.8025873 1.0000000 0.803 NA NA
EGFR ponatinib 0.8071948 1.0000000 0.807 NA NA
DNMT3A ponatinib 0.8077015 1.0000000 0.808 NA NA
CRLF2 ponatinib 0.8169613 1.0000000 0.817 NA NA
PAX5 ponatinib 0.8197075 1.0000000 0.820 NA NA
MET ponatinib 0.8335133 1.0000000 0.834 NA NA
MYCN ponatinib 0.8345316 1.0000000 0.835 NA NA
GATA3 ponatinib 0.8404030 1.0000000 0.840 NA NA
MGMT ponatinib 0.8464506 1.0000000 0.846 NA NA
ALK ponatinib 0.8510931 1.0000000 0.851 NA NA
TP53 ponatinib 0.8681882 1.0000000 0.868 NA NA
CREBBP ponatinib 0.8696111 1.0000000 0.870 NA NA
FLT3 ponatinib 0.8710999 1.0000000 0.871 NA NA
SMC1A ponatinib 0.8852339 1.0000000 0.885 NA NA
TSC2 ponatinib 0.8936686 1.0000000 0.894 NA NA
PRPF8 ponatinib 0.9203095 1.0000000 0.920 NA NA
FGFR2 ponatinib 0.9497712 1.0000000 0.950 NA NA
BCORL1 ponatinib 0.9769375 1.0000000 0.977 NA NA
FGFR3 ponatinib 1.0000000 1.0000000 1.000 NA NA
NPM1 ponatinib 1.0000000 1.0000000 1.000 NA NA
PTCH1 ponatinib 1.0000000 1.0000000 1.000 NA NA
MAP2K1 ponatinib 1.0000000 1.0000000 1.000 NA NA
IDH1 ponatinib 1.0000000 1.0000000 1.000 NA NA
KIT ponatinib 1.0000000 1.0000000 1.000 NA NA
JAK3 ponatinib 1.0000000 1.0000000 1.000 NA NA
BRCA1 ponatinib 1.0000000 1.0000000 1.000 NA NA
AKT2 ponatinib 1.0000000 1.0000000 1.000 NA NA
CBL ponatinib 1.0000000 1.0000000 1.000 NA NA
ZRSR2 ponatinib 1.0000000 1.0000000 1.000 NA NA
AKT1 ponatinib 1.0000000 1.0000000 1.000 NA NA
BCOR sunitinib 0.1051925 1.0000000 0.11 NA NA
GATA3 sunitinib 0.1535764 1.0000000 0.15 NA NA
SMC3 sunitinib 0.1588338 1.0000000 0.16 NA NA
KRAS sunitinib 0.1719754 1.0000000 0.17 NA NA
SETD2 sunitinib 0.1771126 1.0000000 0.18 NA NA
SETBP1 sunitinib 0.1994576 1.0000000 0.20 NA NA
KMT2A sunitinib 0.2027302 1.0000000 0.20 NA NA
EZH2 sunitinib 0.2112995 1.0000000 0.21 NA NA
TET2 sunitinib 0.2415666 1.0000000 0.24 NA NA
ZRSR2 sunitinib 0.2452781 1.0000000 0.25 NA NA
TP53 sunitinib 0.3081686 1.0000000 0.31 NA NA
CREBBP sunitinib 0.3607821 1.0000000 0.36 NA NA
ASXL1 sunitinib 0.3710934 1.0000000 0.37 NA NA
GNB1 sunitinib 0.3710934 1.0000000 0.37 NA NA
XPO1 sunitinib 0.3710934 1.0000000 0.37 NA NA
RET sunitinib 0.3710934 1.0000000 0.37 NA NA
BCORL1 sunitinib 0.3827331 1.0000000 0.38 NA NA
WT1 sunitinib 0.3864762 1.0000000 0.39 NA NA
STAG2 sunitinib 0.4532547 1.0000000 0.45 NA NA
PRPF8 sunitinib 0.4532547 1.0000000 0.45 NA NA
CDK4 sunitinib 0.4681599 1.0000000 0.47 NA NA
DPYD sunitinib 0.4681599 1.0000000 0.47 NA NA
NOTCH1 sunitinib 0.4767414 1.0000000 0.48 NA NA
FGFR3 sunitinib 0.4874533 1.0000000 0.49 NA NA
CALR sunitinib 0.5402914 1.0000000 0.54 NA NA
PDGFB sunitinib 0.5402914 1.0000000 0.54 NA NA
CD79B sunitinib 0.5402914 1.0000000 0.54 NA NA
PDGFRB sunitinib 0.5402914 1.0000000 0.54 NA NA
TSC1 sunitinib 0.5402914 1.0000000 0.54 NA NA
CTCF sunitinib 0.5524529 1.0000000 0.55 NA NA
ERBB4 sunitinib 0.5565355 1.0000000 0.56 NA NA
KIT sunitinib 0.5581846 1.0000000 0.56 NA NA
NRAS sunitinib 0.5623426 1.0000000 0.56 NA NA
ERBB3 sunitinib 0.5676354 1.0000000 0.57 NA NA
EGFR sunitinib 0.6170751 1.0000000 0.62 NA NA
VHL sunitinib 0.6373519 1.0000000 0.64 NA NA
FBXW7 sunitinib 0.6373519 1.0000000 0.64 NA NA
ROS1 sunitinib 0.6625206 1.0000000 0.66 NA NA
GNAS sunitinib 0.6926109 1.0000000 0.69 NA NA
FLT3 sunitinib 0.6985354 1.0000000 0.70 NA NA
ALK sunitinib 0.7147007 1.0000000 0.71 NA NA
CTNNB1 sunitinib 0.7236736 1.0000000 0.72 NA NA
STAT3 sunitinib 0.7236736 1.0000000 0.72 NA NA
IKZF1 sunitinib 0.7236736 1.0000000 0.72 NA NA
MET sunitinib 0.7236736 1.0000000 0.72 NA NA
PML sunitinib 0.7373721 1.0000000 0.74 NA NA
ATM sunitinib 0.7499077 1.0000000 0.75 NA NA
IL7R sunitinib 0.7728300 1.0000000 0.77 NA NA
FGFR2 sunitinib 0.7728300 1.0000000 0.77 NA NA
SF3B1 sunitinib 0.8025873 1.0000000 0.80 NA NA
WHSC1 sunitinib 0.8169613 1.0000000 0.82 NA NA
EML4 sunitinib 0.9089940 1.0000000 0.91 NA NA
PAX5 sunitinib 1.0000000 1.0000000 1.00 NA NA
PTEN sunitinib 1.0000000 1.0000000 1.00 NA NA
GATA2 sunitinib 1.0000000 1.0000000 1.00 NA NA
BRCA2 sunitinib 1.0000000 1.0000000 1.00 NA NA
CBLB sunitinib 1.0000000 1.0000000 1.00 NA NA
G6PD sunitinib 1.0000000 1.0000000 1.00 NA NA
ABL1 sunitinib 1.0000000 1.0000000 1.00 NA NA
PDGFRA sunitinib 1.0000000 1.0000000 1.00 NA NA
MYCN sunitinib 1.0000000 1.0000000 1.00 NA NA
NCOA2 sunitinib 1.0000000 1.0000000 1.00 NA NA
AR sunitinib 1.0000000 1.0000000 1.00 NA NA
BRCA1 sunitinib 1.0000000 1.0000000 1.00 NA NA
SF1 sunitinib 1.0000000 1.0000000 1.00 NA NA
ERBB2 sunitinib 1.0000000 1.0000000 1.00 NA NA
SMC1A sunitinib 1.0000000 1.0000000 1.00 NA NA
MGMT sunitinib 1.0000000 1.0000000 1.00 NA NA
PTCH1 sunitinib 1.0000000 1.0000000 1.00 NA NA
NOTCH2 sunitinib 1.0000000 1.0000000 1.00 NA NA
CBL sunitinib 1.0000000 1.0000000 1.00 NA NA
CRLF2 sunitinib 1.0000000 1.0000000 1.00 NA NA
BTK sunitinib 1.0000000 1.0000000 1.00 NA NA
ETV6 sunitinib 1.0000000 1.0000000 1.00 NA NA
FGFR1 sunitinib 1.0000000 1.0000000 1.00 NA NA
GNAS lapatinib 0.0851260 1.0000000 0.085 NA NA
NOTCH2 lapatinib 0.1051925 1.0000000 0.105 NA NA
TP53 lapatinib 0.1189502 1.0000000 0.119 NA NA
EGFR lapatinib 0.1336144 1.0000000 0.134 NA NA
NRAS lapatinib 0.1475014 1.0000000 0.148 NA NA
CBLB lapatinib 0.1752442 1.0000000 0.175 NA NA
SETD2 lapatinib 0.1771126 1.0000000 0.177 NA NA
AR lapatinib 0.1839855 1.0000000 0.184 NA NA
SF3B1 lapatinib 0.2112995 1.0000000 0.211 NA NA
KIT lapatinib 0.2415666 1.0000000 0.242 NA NA
TET2 lapatinib 0.2415666 1.0000000 0.242 NA NA
STAT3 lapatinib 0.2888444 1.0000000 0.289 NA NA
IKZF1 lapatinib 0.2888444 1.0000000 0.289 NA NA
PDGFRA lapatinib 0.3602164 1.0000000 0.360 NA NA
G6PD lapatinib 0.3710934 1.0000000 0.371 NA NA
MYCN lapatinib 0.3710934 1.0000000 0.371 NA NA
ASXL1 lapatinib 0.3710934 1.0000000 0.371 NA NA
GNB1 lapatinib 0.3710934 1.0000000 0.371 NA NA
ROS1 lapatinib 0.3827331 1.0000000 0.383 NA NA
NCOA2 lapatinib 0.3827331 1.0000000 0.383 NA NA
FGFR2 lapatinib 0.3864762 1.0000000 0.386 NA NA
NOTCH1 lapatinib 0.4064565 1.0000000 0.406 NA NA
ERBB3 lapatinib 0.4236225 1.0000000 0.424 NA NA
STAG2 lapatinib 0.4532547 1.0000000 0.453 NA NA
EZH2 lapatinib 0.4532547 1.0000000 0.453 NA NA
PRPF8 lapatinib 0.4532547 1.0000000 0.453 NA NA
BCORL1 lapatinib 0.4532547 1.0000000 0.453 NA NA
DPYD lapatinib 0.4681599 1.0000000 0.468 NA NA
GATA3 lapatinib 0.4755327 1.0000000 0.476 NA NA
WHSC1 lapatinib 0.4874533 1.0000000 0.487 NA NA
ABL1 lapatinib 0.4874533 1.0000000 0.487 NA NA
FGFR3 lapatinib 0.4874533 1.0000000 0.487 NA NA
BCOR lapatinib 0.4874533 1.0000000 0.487 NA NA
PDGFB lapatinib 0.5402914 1.0000000 0.540 NA NA
PDGFRB lapatinib 0.5402914 1.0000000 0.540 NA NA
MGMT lapatinib 0.5402914 1.0000000 0.540 NA NA
ALK lapatinib 0.5532002 1.0000000 0.553 NA NA
VHL lapatinib 0.6373519 1.0000000 0.637 NA NA
SMC3 lapatinib 0.6385921 1.0000000 0.639 NA NA
KMT2A lapatinib 0.6480769 1.0000000 0.648 NA NA
PTEN lapatinib 0.6627994 1.0000000 0.663 NA NA
ZRSR2 lapatinib 0.6985354 1.0000000 0.699 NA NA
CTNNB1 lapatinib 0.7236736 1.0000000 0.724 NA NA
MET lapatinib 0.7236736 1.0000000 0.724 NA NA
EML4 lapatinib 0.7316568 1.0000000 0.732 NA NA
ATM lapatinib 0.7339383 1.0000000 0.734 NA NA
PML lapatinib 0.7373721 1.0000000 0.737 NA NA
IL7R lapatinib 0.7728300 1.0000000 0.773 NA NA
SETBP1 lapatinib 0.8306642 1.0000000 0.831 NA NA
CREBBP lapatinib 0.8549744 1.0000000 0.855 NA NA
PAX5 lapatinib 1.0000000 1.0000000 1.000 NA NA
WT1 lapatinib 1.0000000 1.0000000 1.000 NA NA
GATA2 lapatinib 1.0000000 1.0000000 1.000 NA NA
BRCA2 lapatinib 1.0000000 1.0000000 1.000 NA NA
KRAS lapatinib 1.0000000 1.0000000 1.000 NA NA
CDK4 lapatinib 1.0000000 1.0000000 1.000 NA NA
BRCA1 lapatinib 1.0000000 1.0000000 1.000 NA NA
CALR lapatinib 1.0000000 1.0000000 1.000 NA NA
SF1 lapatinib 1.0000000 1.0000000 1.000 NA NA
ERBB4 lapatinib 1.0000000 1.0000000 1.000 NA NA
ERBB2 lapatinib 1.0000000 1.0000000 1.000 NA NA
CD79B lapatinib 1.0000000 1.0000000 1.000 NA NA
CTCF lapatinib 1.0000000 1.0000000 1.000 NA NA
SMC1A lapatinib 1.0000000 1.0000000 1.000 NA NA
XPO1 lapatinib 1.0000000 1.0000000 1.000 NA NA
PTCH1 lapatinib 1.0000000 1.0000000 1.000 NA NA
TSC1 lapatinib 1.0000000 1.0000000 1.000 NA NA
FLT3 lapatinib 1.0000000 1.0000000 1.000 NA NA
RET lapatinib 1.0000000 1.0000000 1.000 NA NA
CBL lapatinib 1.0000000 1.0000000 1.000 NA NA
CRLF2 lapatinib 1.0000000 1.0000000 1.000 NA NA
FBXW7 lapatinib 1.0000000 1.0000000 1.000 NA NA
BTK lapatinib 1.0000000 1.0000000 1.000 NA NA
ETV6 lapatinib 1.0000000 1.0000000 1.000 NA NA
FGFR1 lapatinib 1.0000000 1.0000000 1.000 NA NA
ALK dasatinib 0.0443755 1.0000000 0.044
NA
KMT2A dasatinib 0.0507985 1.0000000 0.051 NA NA
GNAS dasatinib 0.0752537 1.0000000 0.075 NA NA
NOTCH2 dasatinib 0.1051925 1.0000000 0.105 NA NA
NRAS dasatinib 0.1475014 1.0000000 0.148 NA NA
SETD2 dasatinib 0.1771126 1.0000000 0.177 NA NA
AR dasatinib 0.1839855 1.0000000 0.184 NA NA
TET2 dasatinib 0.2415666 1.0000000 0.242 NA NA
FLT3 dasatinib 0.2452781 1.0000000 0.245 NA NA
ABL1 dasatinib 0.2471600 1.0000000 0.247 NA NA
BCOR dasatinib 0.2471600 1.0000000 0.247 NA NA
CTNNB1 dasatinib 0.2888444 1.0000000 0.289 NA NA
IKZF1 dasatinib 0.2888444 1.0000000 0.289 NA NA
MYCN dasatinib 0.3710934 1.0000000 0.371 NA NA
ASXL1 dasatinib 0.3710934 1.0000000 0.371 NA NA
XPO1 dasatinib 0.3710934 1.0000000 0.371 NA NA
RET dasatinib 0.3710934 1.0000000 0.371 NA NA
BCORL1 dasatinib 0.3827331 1.0000000 0.383 NA NA
WT1 dasatinib 0.3864762 1.0000000 0.386 NA NA
EGFR dasatinib 0.4046568 1.0000000 0.405 NA NA
EML4 dasatinib 0.4236225 1.0000000 0.424 NA NA
SF3B1 dasatinib 0.4532547 1.0000000 0.453 NA NA
BRCA2 dasatinib 0.4567504 1.0000000 0.457 NA NA
DPYD dasatinib 0.4681599 1.0000000 0.468 NA NA
WHSC1 dasatinib 0.4874533 1.0000000 0.487 NA NA
KRAS dasatinib 0.5346942 1.0000000 0.535 NA NA
CALR dasatinib 0.5402914 1.0000000 0.540 NA NA
PDGFB dasatinib 0.5402914 1.0000000 0.540 NA NA
CD79B dasatinib 0.5402914 1.0000000 0.540 NA NA
PDGFRB dasatinib 0.5402914 1.0000000 0.540 NA NA
MGMT dasatinib 0.5402914 1.0000000 0.540 NA NA
TSC1 dasatinib 0.5402914 1.0000000 0.540 NA NA
CRLF2 dasatinib 0.5402914 1.0000000 0.540 NA NA
BTK dasatinib 0.5402914 1.0000000 0.540 NA NA
CBLB dasatinib 0.5612758 1.0000000 0.561 NA NA
PDGFRA dasatinib 0.5830249 1.0000000 0.583 NA NA
ATM dasatinib 0.5952328 1.0000000 0.595 NA NA
TP53 dasatinib 0.6343828 1.0000000 0.634 NA NA
VHL dasatinib 0.6373519 1.0000000 0.637 NA NA
FBXW7 dasatinib 0.6373519 1.0000000 0.637 NA NA
ROS1 dasatinib 0.6625206 1.0000000 0.663 NA NA
NCOA2 dasatinib 0.6625206 1.0000000 0.663 NA NA
CREBBP dasatinib 0.7147007 1.0000000 0.715 NA NA
BRCA1 dasatinib 0.7212767 1.0000000 0.721 NA NA
ERBB2 dasatinib 0.7212767 1.0000000 0.721 NA NA
GATA3 dasatinib 0.7212767 1.0000000 0.721 NA NA
STAT3 dasatinib 0.7236736 1.0000000 0.724 NA NA
MET dasatinib 0.7236736 1.0000000 0.724 NA NA
IL7R dasatinib 0.7728300 1.0000000 0.773 NA NA
FGFR2 dasatinib 0.7728300 1.0000000 0.773 NA NA
STAG2 dasatinib 0.8025873 1.0000000 0.803 NA NA
EZH2 dasatinib 0.8025873 1.0000000 0.803 NA NA
PRPF8 dasatinib 0.8025873 1.0000000 0.803 NA NA
NOTCH1 dasatinib 0.8125137 1.0000000 0.813 NA NA
PAX5 dasatinib 1.0000000 1.0000000 1.000 NA NA
PTEN dasatinib 1.0000000 1.0000000 1.000 NA NA
SMC3 dasatinib 1.0000000 1.0000000 1.000 NA NA
GATA2 dasatinib 1.0000000 1.0000000 1.000 NA NA
ERBB3 dasatinib 1.0000000 1.0000000 1.000 NA NA
CDK4 dasatinib 1.0000000 1.0000000 1.000 NA NA
G6PD dasatinib 1.0000000 1.0000000 1.000 NA NA
KIT dasatinib 1.0000000 1.0000000 1.000 NA NA
PML dasatinib 1.0000000 1.0000000 1.000 NA NA
FGFR3 dasatinib 1.0000000 1.0000000 1.000 NA NA
SF1 dasatinib 1.0000000 1.0000000 1.000 NA NA
GNB1 dasatinib 1.0000000 1.0000000 1.000 NA NA
ERBB4 dasatinib 1.0000000 1.0000000 1.000 NA NA
CTCF dasatinib 1.0000000 1.0000000 1.000 NA NA
SMC1A dasatinib 1.0000000 1.0000000 1.000 NA NA
PTCH1 dasatinib 1.0000000 1.0000000 1.000 NA NA
ZRSR2 dasatinib 1.0000000 1.0000000 1.000 NA NA
CBL dasatinib 1.0000000 1.0000000 1.000 NA NA
SETBP1 dasatinib 1.0000000 1.0000000 1.000 NA NA
ETV6 dasatinib 1.0000000 1.0000000 1.000 NA NA
FGFR1 dasatinib 1.0000000 1.0000000 1.000 NA NA
ALK imatinib 0.0999747 1.0000000 0.10 NA NA
NRAS imatinib 0.1415789 1.0000000 0.14 NA NA
CREBBP imatinib 0.1436861 1.0000000 0.14 NA NA
FGFR2 imatinib 0.1489147 1.0000000 0.15 NA NA
ERBB2 imatinib 0.1535764 1.0000000 0.15 NA NA
SMC3 imatinib 0.1588338 1.0000000 0.16 NA NA
AR imatinib 0.1839855 1.0000000 0.18 NA NA
ATM imatinib 0.2022936 1.0000000 0.20 NA NA
KMT2A imatinib 0.2027302 1.0000000 0.20 NA NA
SF3B1 imatinib 0.2112995 1.0000000 0.21 NA NA
BRCA2 imatinib 0.2148469 1.0000000 0.21 NA NA
TET2 imatinib 0.2415666 1.0000000 0.24 NA NA
FLT3 imatinib 0.2452781 1.0000000 0.25 NA NA
BCOR imatinib 0.2471600 1.0000000 0.25 NA NA
TP53 imatinib 0.2481114 1.0000000 0.25 NA NA
KRAS imatinib 0.2637629 1.0000000 0.26 NA NA
GATA3 imatinib 0.2845027 1.0000000 0.28 NA NA
ASXL1 imatinib 0.2888444 1.0000000 0.29 NA NA
IKZF1 imatinib 0.2888444 1.0000000 0.29 NA NA
PTEN imatinib 0.3089378 1.0000000 0.31 NA NA
PML imatinib 0.3144127 1.0000000 0.31 NA NA
GNB1 imatinib 0.3710934 1.0000000 0.37 NA NA
RET imatinib 0.3710934 1.0000000 0.37 NA NA
NCOA2 imatinib 0.3827331 1.0000000 0.38 NA NA
WT1 imatinib 0.3864762 1.0000000 0.39 NA NA
PRPF8 imatinib 0.4532547 1.0000000 0.45 NA NA
DPYD imatinib 0.4681599 1.0000000 0.47 NA NA
BRCA1 imatinib 0.4755327 1.0000000 0.48 NA NA
WHSC1 imatinib 0.4874533 1.0000000 0.49 NA NA
FGFR3 imatinib 0.4874533 1.0000000 0.49 NA NA
NOTCH2 imatinib 0.4874533 1.0000000 0.49 NA NA
CALR imatinib 0.5402914 1.0000000 0.54 NA NA
PDGFB imatinib 0.5402914 1.0000000 0.54 NA NA
TSC1 imatinib 0.5402914 1.0000000 0.54 NA NA
CRLF2 imatinib 0.5402914 1.0000000 0.54 NA NA
BTK imatinib 0.5402914 1.0000000 0.54 NA NA
GNAS imatinib 0.5532002 1.0000000 0.55 NA NA
ERBB4 imatinib 0.5565355 1.0000000 0.56 NA NA
EML4 imatinib 0.5676354 1.0000000 0.57 NA NA
VHL imatinib 0.6373519 1.0000000 0.64 NA NA
FBXW7 imatinib 0.6373519 1.0000000 0.64 NA NA
ROS1 imatinib 0.6625206 1.0000000 0.66 NA NA
BCORL1 imatinib 0.6625206 1.0000000 0.66 NA NA
ZRSR2 imatinib 0.6985354 1.0000000 0.70 NA NA
CTNNB1 imatinib 0.7236736 1.0000000 0.72 NA NA
STAT3 imatinib 0.7236736 1.0000000 0.72 NA NA
MET imatinib 0.7236736 1.0000000 0.72 NA NA
IL7R imatinib 0.7728300 1.0000000 0.77 NA NA
SETBP1 imatinib 0.8306642 1.0000000 0.83 NA NA
CBLB imatinib 0.8464506 1.0000000 0.85 NA NA
EGFR imatinib 0.8676323 1.0000000 0.87 NA NA
SETD2 imatinib 0.8807910 1.0000000 0.88 NA NA
PAX5 imatinib 1.0000000 1.0000000 1.00 NA NA
GATA2 imatinib 1.0000000 1.0000000 1.00 NA NA
ERBB3 imatinib 1.0000000 1.0000000 1.00 NA NA
CDK4 imatinib 1.0000000 1.0000000 1.00 NA NA
G6PD imatinib 1.0000000 1.0000000 1.00 NA NA
ABL1 imatinib 1.0000000 1.0000000 1.00 NA NA
KIT imatinib 1.0000000 1.0000000 1.00 NA NA
STAG2 imatinib 1.0000000 1.0000000 1.00 NA NA
EZH2 imatinib 1.0000000 1.0000000 1.00 NA NA
NOTCH1 imatinib 1.0000000 1.0000000 1.00 NA NA
PDGFRA imatinib 1.0000000 1.0000000 1.00 NA NA
MYCN imatinib 1.0000000 1.0000000 1.00 NA NA
SF1 imatinib 1.0000000 1.0000000 1.00 NA NA
CD79B imatinib 1.0000000 1.0000000 1.00 NA NA
PDGFRB imatinib 1.0000000 1.0000000 1.00 NA NA
CTCF imatinib 1.0000000 1.0000000 1.00 NA NA
SMC1A imatinib 1.0000000 1.0000000 1.00 NA NA
XPO1 imatinib 1.0000000 1.0000000 1.00 NA NA
MGMT imatinib 1.0000000 1.0000000 1.00 NA NA
PTCH1 imatinib 1.0000000 1.0000000 1.00 NA NA
CBL imatinib 1.0000000 1.0000000 1.00 NA NA
ETV6 imatinib 1.0000000 1.0000000 1.00 NA NA
FGFR1 imatinib 1.0000000 1.0000000 1.00 NA NA
ALK erlotinib 0.0752537 1.0000000 0.075 NA NA
TP53 erlotinib 0.1403572 1.0000000 0.140 NA NA
ATM erlotinib 0.1453139 1.0000000 0.145 NA NA
NRAS erlotinib 0.1637344 1.0000000 0.164 NA NA
SF3B1 erlotinib 0.2112995 1.0000000 0.211 NA NA
KIT erlotinib 0.2415666 1.0000000 0.242 NA NA
NOTCH2 erlotinib 0.2452781 1.0000000 0.245 NA NA
FGFR2 erlotinib 0.2452781 1.0000000 0.245 NA NA
FGFR3 erlotinib 0.2471600 1.0000000 0.247 NA NA
NOTCH1 erlotinib 0.2781564 1.0000000 0.278 NA NA
TET2 erlotinib 0.2888444 1.0000000 0.289 NA NA
AR erlotinib 0.3014437 1.0000000 0.301 NA NA
CREBBP erlotinib 0.3230126 1.0000000 0.323 NA NA
CBLB erlotinib 0.3329216 1.0000000 0.333 NA NA
GATA3 erlotinib 0.3475580 1.0000000 0.348 NA NA
PDGFRA erlotinib 0.3602164 1.0000000 0.360 NA NA
IL7R erlotinib 0.3710934 1.0000000 0.371 NA NA
ASXL1 erlotinib 0.3710934 1.0000000 0.371 NA NA
ROS1 erlotinib 0.3827331 1.0000000 0.383 NA NA
NCOA2 erlotinib 0.3827331 1.0000000 0.383 NA NA
WT1 erlotinib 0.3864762 1.0000000 0.386 NA NA
PML erlotinib 0.4344457 1.0000000 0.434 NA NA
SETD2 erlotinib 0.4755327 1.0000000 0.476 NA NA
ABL1 erlotinib 0.4874533 1.0000000 0.487 NA NA
KMT2A erlotinib 0.4896603 1.0000000 0.490 NA NA
GNAS erlotinib 0.5185170 1.0000000 0.519 NA NA
CD79B erlotinib 0.5402914 1.0000000 0.540 NA NA
MGMT erlotinib 0.5402914 1.0000000 0.540 NA NA
FLT3 erlotinib 0.5402914 1.0000000 0.540 NA NA
BCORL1 erlotinib 0.5581846 1.0000000 0.558 NA NA
VHL erlotinib 0.6373519 1.0000000 0.637 NA NA
CTNNB1 erlotinib 0.7236736 1.0000000 0.724 NA NA
KRAS erlotinib 0.7889848 1.0000000 0.789 NA NA
ERBB4 erlotinib 0.8025873 1.0000000 0.803 NA NA
EGFR erlotinib 0.8169613 1.0000000 0.817 NA NA
BRCA1 erlotinib 0.8247781 1.0000000 0.825 NA NA
ERBB2 erlotinib 0.8247781 1.0000000 0.825 NA NA
SETBP1 erlotinib 0.8807910 1.0000000 0.881 NA NA
PTEN erlotinib 0.8844342 1.0000000 0.884 NA NA
BRCA2 erlotinib 0.8936947 1.0000000 0.894 NA NA
PAX5 erlotinib 1.0000000 1.0000000 1.000 NA NA
SMC3 erlotinib 1.0000000 1.0000000 1.000 NA NA
WHSC1 erlotinib 1.0000000 1.0000000 1.000 NA NA
GATA2 erlotinib 1.0000000 1.0000000 1.000 NA NA
ERBB3 erlotinib 1.0000000 1.0000000 1.000 NA NA
CDK4 erlotinib 1.0000000 1.0000000 1.000 NA NA
STAG2 erlotinib 1.0000000 1.0000000 1.000 NA NA
MYCN erlotinib 1.0000000 1.0000000 1.000 NA NA
CALR erlotinib 1.0000000 1.0000000 1.000 NA NA
SF1 erlotinib 1.0000000 1.0000000 1.000 NA NA
GNB1 erlotinib 1.0000000 1.0000000 1.000 NA NA
EML4 erlotinib 1.0000000 1.0000000 1.000 NA NA
BCOR erlotinib 1.0000000 1.0000000 1.000 NA NA
G6PD erlotinib 1.0000000 1.0000000 1.000 NA NA
CTCF erlotinib 1.0000000 1.0000000 1.000 NA NA
SMC1A erlotinib 1.0000000 1.0000000 1.000 NA NA
XPO1 erlotinib 1.0000000 1.0000000 1.000 NA NA
PTCH1 erlotinib 1.0000000 1.0000000 1.000 NA NA
IKZF1 erlotinib 1.0000000 1.0000000 1.000 NA NA
TSC1 erlotinib 1.0000000 1.0000000 1.000 NA NA
ZRSR2 erlotinib 1.0000000 1.0000000 1.000 NA NA
RET erlotinib 1.0000000 1.0000000 1.000 NA NA
CBL erlotinib 1.0000000 1.0000000 1.000 NA NA
MET erlotinib 1.0000000 1.0000000 1.000 NA NA
CRLF2 erlotinib 1.0000000 1.0000000 1.000 NA NA
ETV6 erlotinib 1.0000000 1.0000000 1.000 NA NA
BTK erlotinib 1.0000000 1.0000000 1.000 NA NA
FGFR1 erlotinib 1.0000000 1.0000000 1.000 NA NA
ERBB3 crizotinib 0.0519887 1.0000000 0.052 NA NA
NOTCH1 crizotinib 0.1547052 1.0000000 0.155 NA NA
AR crizotinib 0.1839855 1.0000000 0.184 NA NA
NCOA2 crizotinib 0.1904303 1.0000000 0.190 NA NA
SETBP1 crizotinib 0.1994576 1.0000000 0.199 NA NA
STAG2 crizotinib 0.2112995 1.0000000 0.211 NA NA
EZH2 crizotinib 0.2112995 1.0000000 0.211 NA NA
SF3B1 crizotinib 0.2112995 1.0000000 0.211 NA NA
CTCF crizotinib 0.2347637 1.0000000 0.235 NA NA
TET2 crizotinib 0.2415666 1.0000000 0.242 NA NA
FLT3 crizotinib 0.2452781 1.0000000 0.245 NA NA
CTNNB1 crizotinib 0.2888444 1.0000000 0.289 NA NA
STAT3 crizotinib 0.2888444 1.0000000 0.289 NA NA
ASXL1 crizotinib 0.2888444 1.0000000 0.289 NA NA
MET crizotinib 0.2888444 1.0000000 0.289 NA NA
EML4 crizotinib 0.3035890 1.0000000 0.304 NA NA
NRAS crizotinib 0.3495748 1.0000000 0.350 NA NA
GNB1 crizotinib 0.3710934 1.0000000 0.371 NA NA
XPO1 crizotinib 0.3710934 1.0000000 0.371 NA NA
ETV6 crizotinib 0.3710934 1.0000000 0.371 NA NA
BCORL1 crizotinib 0.3827331 1.0000000 0.383 NA NA
KRAS crizotinib 0.3847384 1.0000000 0.385 NA NA
PRPF8 crizotinib 0.4532547 1.0000000 0.453 NA NA
PDGFRA crizotinib 0.4641916 1.0000000 0.464 NA NA
GATA3 crizotinib 0.4755327 1.0000000 0.476 NA NA
FGFR3 crizotinib 0.4874533 1.0000000 0.487 NA NA
CALR crizotinib 0.5402914 1.0000000 0.540 NA NA
PDGFB crizotinib 0.5402914 1.0000000 0.540 NA NA
CD79B crizotinib 0.5402914 1.0000000 0.540 NA NA
PDGFRB crizotinib 0.5402914 1.0000000 0.540 NA NA
TSC1 crizotinib 0.5402914 1.0000000 0.540 NA NA
BTK crizotinib 0.5402914 1.0000000 0.540 NA NA
TP53 crizotinib 0.5409061 1.0000000 0.541 NA NA
KMT2A crizotinib 0.5522142 1.0000000 0.552 NA NA
GNAS crizotinib 0.5532002 1.0000000 0.553 NA NA
KIT crizotinib 0.5581846 1.0000000 0.558 NA NA
CBLB crizotinib 0.5612758 1.0000000 0.561 NA NA
EGFR crizotinib 0.6170751 1.0000000 0.617 NA NA
FBXW7 crizotinib 0.6373519 1.0000000 0.637 NA NA
SMC3 crizotinib 0.6385921 1.0000000 0.639 NA NA
SETD2 crizotinib 0.6527828 1.0000000 0.653 NA NA
ATM crizotinib 0.6708259 1.0000000 0.671 NA NA
ERBB2 crizotinib 0.7212767 1.0000000 0.721 NA NA
IKZF1 crizotinib 0.7236736 1.0000000 0.724 NA NA
ERBB4 crizotinib 0.7687598 1.0000000 0.769 NA NA
WT1 crizotinib 0.7728300 1.0000000 0.773 NA NA
FGFR2 crizotinib 0.7728300 1.0000000 0.773 NA NA
WHSC1 crizotinib 0.8169613 1.0000000 0.817 NA NA
ABL1 crizotinib 0.8169613 1.0000000 0.817 NA NA
BCOR crizotinib 0.8169613 1.0000000 0.817 NA NA
PTEN crizotinib 0.8844342 1.0000000 0.884 NA NA
PAX5 crizotinib 1.0000000 1.0000000 1.000 NA NA
ROS1 crizotinib 1.0000000 1.0000000 1.000 NA NA
IL7R crizotinib 1.0000000 1.0000000 1.000 NA NA
GATA2 crizotinib 1.0000000 1.0000000 1.000 NA NA
ALK crizotinib 1.0000000 1.0000000 1.000 NA NA
BRCA2 crizotinib 1.0000000 1.0000000 1.000 NA NA
CREBBP crizotinib 1.0000000 1.0000000 1.000 NA NA
CDK4 crizotinib 1.0000000 1.0000000 1.000 NA NA
G6PD crizotinib 1.0000000 1.0000000 1.000 NA NA
MYCN crizotinib 1.0000000 1.0000000 1.000 NA NA
PML crizotinib 1.0000000 1.0000000 1.000 NA NA
BRCA1 crizotinib 1.0000000 1.0000000 1.000 NA NA
DPYD crizotinib 1.0000000 1.0000000 1.000 NA NA
SF1 crizotinib 1.0000000 1.0000000 1.000 NA NA
VHL crizotinib 1.0000000 1.0000000 1.000 NA NA
SMC1A crizotinib 1.0000000 1.0000000 1.000 NA NA
MGMT crizotinib 1.0000000 1.0000000 1.000 NA NA
PTCH1 crizotinib 1.0000000 1.0000000 1.000 NA NA
NOTCH2 crizotinib 1.0000000 1.0000000 1.000 NA NA
ZRSR2 crizotinib 1.0000000 1.0000000 1.000 NA NA
RET crizotinib 1.0000000 1.0000000 1.000 NA NA
CBL crizotinib 1.0000000 1.0000000 1.000 NA NA
CRLF2 crizotinib 1.0000000 1.0000000 1.000 NA NA
FGFR1 crizotinib 1.0000000 1.0000000 1.000 NA NA 
wilcox_gdsc_gene_lvlA_plot <- ggplot(data = gdsc_signif_lvlA) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gdsc_gene_lvlA_plot

5.3 Screen boxplots

Mutation status boxplots for genes identified in G2P.

genes_lvlA_filt <- c("KRAS", "EGFR", "MET", "ALK", "BRAF", "ERBB2", "ABL1", "ROS1", "KIT", "DPYD", "PDGFRA", "RET", "BRCA1", "UGT1A1", "IDH2", "ESR1", "TPMT", "BRCA2", "PDGFRB", "G6PD", "PML", "TSC1", "FLT3", "ERBB3", "CYP19A1", "AKT1", "PTCH1", "MGMT", "DNMT3A", "MYD88", "PDGFB", "TSC2", "NPM1", "JAK2")

5.3.1 CRISPR

crispr_ptmuts_lvlA_filt <- filter(crispr_data_ptmuts, Hugo_Symbol %in% genes_lvlA_filt)
crispr_ptmuts_lvlA_filt$Hugo_Symbol <- ordered(crispr_ptmuts_lvlA_filt$Hugo_Symbol, levels = genes_lvlA_filt)
crispr_ptmuts_lvlA_filt_color <- as.character(crispr_ptmuts_lvlA_filt$Color_Nonsilent)
names(crispr_ptmuts_lvlA_filt_color) <- crispr_ptmuts_lvlA_filt$Mutation_Status_Nonsilent

label_text <- data.frame(p.signif.adj = crispr_signif_lvlA$p.signif.adj, Hugo_Symbol = crispr_signif_lvlA$Hugo_Symbol)
label_text <- filter(label_text, Hugo_Symbol %in% genes_lvlA_filt)
label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = genes_lvlA_filt)

crispr_ptmuts_lvlA_filt_plot_faceted <- ggplot(data = crispr_ptmuts_lvlA_filt, aes(x = Mutation_Status_Nonsilent, y = Score)) +
  facet_wrap(~ Hugo_Symbol, drop = FALSE, ncol = length(genes_lvlA)) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85)) +
  scale_fill_manual(values = crispr_ptmuts_lvlA_filt_color) +
  guides(color = FALSE) +
  geom_text(data = label_text, mapping = aes(x = 1.5, y = 2, label = p.signif.adj)) +
  theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
  labs(fill = "Mutation Status", y = "CERES Score", x = "Mutation Status")
crispr_ptmuts_lvlA_filt_plot_faceted

# ggsave("./plots_18Q3/manuscript/crispr_ptmuts_lvlA_filt_plot_faceted.png", crispr_ptmuts_lvlA_filt_plot_faceted, device = "png", dpi = 450, width = 20, height = 4, units = "in")

5.3.2 CCLE

ccle_ptmuts_lvlA_filt <- filter(ccle_data_ptmuts, Hugo_Symbol %in% genes_lvlA_filt)
ccle_ptmuts_lvlA_filt$Hugo_Symbol <- ordered(ccle_ptmuts_lvlA_filt$Hugo_Symbol, levels = genes_lvlA_filt)
ccle_drugs <- as.character(unique(ccle_ptmuts_lvlA_filt$Drug))

Plot code:

ccle_lvlA_drugboxplots <- lapply(ccle_drugs, makeDrugBoxplots, dataset = "CCLE")
ccle_lvlA_drugboxplot_paths <- paste0(ccle_drugs, "_ccle_boxplots.png")
pwalk(list(ccle_lvlA_drugboxplot_paths, ccle_lvlA_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/ccle_lvlA_boxplots", dpi = 450, width = 20, height = 4, units = "in")

Data management:

ccle_lvlA_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/ccle_lvlA_boxplots", full.names = TRUE))
names(ccle_lvlA_drugboxplots) <- str_replace_all(ccle_lvlA_drugboxplots, c("_ccle_boxplots.png" = "", "./plots_18Q3/manuscript/ccle_lvlA_boxplots/" = ""))
bsselect(ccle_lvlA_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)

5.3.3 CTRP

ctrp_ptmuts_lvlA_filt <- filter(ctrp_data_ptmuts, Hugo_Symbol %in% genes_lvlA_filt)
ctrp_ptmuts_lvlA_filt$Hugo_Symbol <- ordered(ctrp_ptmuts_lvlA_filt$Hugo_Symbol, levels = genes_lvlA_filt)
ctrp_drugs <- as.character(unique(ctrp_ptmuts_lvlA_filt$Drug))

Plot code:

ctrp_lvlA_drugboxplots <- lapply(ctrp_drugs, makeDrugBoxplots, dataset = "CTRP")
ctrp_lvlA_drugboxplot_paths <- paste0(ctrp_drugs, "_ctrp_boxplots.png")
pwalk(list(ctrp_lvlA_drugboxplot_paths, ctrp_lvlA_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/ctrp_lvlA_boxplots", dpi = 450, width = 20, height = 4, units = "in")

Data management:

ctrp_lvlA_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/ctrp_lvlA_boxplots", full.names = TRUE))
names(ctrp_lvlA_drugboxplots) <- str_replace_all(ctrp_lvlA_drugboxplots, c("_ctrp_boxplots.png" = "", "./plots_18Q3/manuscript/ctrp_lvlA_boxplots/" = ""))
bsselect(ctrp_lvlA_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)

5.3.4 GDSC

gdsc_ptmuts_lvlA_filt <- filter(gdsc_data_ptmuts, Hugo_Symbol %in% genes_lvlA_filt)
gdsc_ptmuts_lvlA_filt$Hugo_Symbol <- ordered(gdsc_ptmuts_lvlA_filt$Hugo_Symbol, levels = genes_lvlA_filt)
gdsc_drugs <- as.character(unique(gdsc_ptmuts_lvlA_filt$Drug))

Plot code:

gdsc_lvlA_drugboxplots <- lapply(gdsc_drugs, makeDrugBoxplots, dataset = "GDSC")
gdsc_lvlA_drugboxplot_paths <- paste0(gdsc_drugs, "_gdsc_boxplots.png")
pwalk(list(gdsc_lvlA_drugboxplot_paths, gdsc_lvlA_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/gdsc_lvlA_boxplots", dpi = 450, width = 20, height = 4, units = "in")

Data management:

gdsc_lvlA_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/gdsc_lvlA_boxplots", full.names = TRUE))
names(gdsc_lvlA_drugboxplots) <- str_replace_all(gdsc_lvlA_drugboxplots, c("_gdsc_boxplots.png" = "", "./plots_18Q3/manuscript/gdsc_lvlA_boxplots/" = ""))
bsselect(gdsc_lvlA_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)

5.4 CRISPR: Point mutation mapping

Match specific point mutations.

g2p_indications <- filter(read.delim("./data_munging/data_mutation_associations_appended.csv", sep = "\t", header = TRUE), Evidence.Level == "A")
maf_g2p_indications <- filter(maf_raw, Genome_Change %in% g2p_indications$MutationName)
crispr_g2p_indications <- merge(maf_g2p_indications, crispr_data_ptmuts, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"))
dup_g2p_indications <- filter(crispr_g2p_indications[, c("Hugo_Symbol", "CCLE_Name", "Broad_ID")] %>% group_by(Hugo_Symbol, CCLE_Name, Broad_ID) %>% tally(), n > 1)
crispr_g2p_indications <- merge(crispr_g2p_indications, dup_g2p_indications, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)
crispr_g2p_indications <- filter(crispr_g2p_indications, is.na(n))

crispr_g2p_indications_plot <- ggplot(crispr_g2p_indications, aes(x = Hugo_Symbol, y = Score)) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  geom_boxplot(alpha = 0.5, color = "lightgray", outlier.shape = NA) +
  geom_jitter(width = 0.3, mapping = aes(color = group_general_lineage_name), size = 1) +
  theme_light() +
  theme(legend.title = element_blank()) +
  labs(x = "Gene", y = "CERES Score")
crispr_g2p_indications_plot

crispr_g2p_indications_muts_plot <- ggplot(crispr_g2p_indications, aes(x = Protein_Change, y = Score)) +
  facet_grid(~ Hugo_Symbol, scales = "free_x", space = "free") +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  geom_boxplot(alpha = 0.5, color = "lightgray", outlier.shape = NA) +
  geom_jitter(width = 0.1, mapping = aes(color = group_general_lineage_name), size = 1) +
  theme_light() +
  theme(legend.title = element_blank(), axis.text.x = element_text(angle = 90, hjust = 1)) +
  labs(x = "Gene", y = "CERES Score")
crispr_g2p_indications_muts_plot

# ggsave("./plots_18Q3/manuscript/crispr_g2p_indications_plot_test.png", crispr_g2p_indications_plot, width = 12, height = 5, units = "in")
# ggsave("./plots_18Q3/manuscript/crispr_g2p_indications_muts_plot_test.png", crispr_g2p_indications_muts_plot, width = 20, height = 5, units = "in")

5.5 Level A: Per-gene grouped plots

Plot code:

crispr_lvlA_groups <- lapply(as.character(genes_lvlA), makeCRISPRgrob, filt_method = "lvlA")
crispr_lvlA_groups_paths <- paste0(genes_lvlA, "_crispr_grouped.png")
pwalk(list(crispr_lvlA_groups_paths, crispr_lvlA_groups), ggsave, path = "./plots_18Q3/crispr_grouped_plots_lvlA", dpi = 300, width = 12, height = 12, units = "in")

Data management:

crispr_lvlA_bygene <- paste0(list.files("./plots_18Q3/crispr_grouped_plots_lvlA", full.names = TRUE))
names(crispr_lvlA_bygene) <- str_replace_all(crispr_lvlA_bygene, c("_crispr_grouped.png" = "", "./plots_18Q3/crispr_grouped_plots_lvlA/" = ""))
crispr_lvlA_order <- c(intersect(crispr_signif_lvlA$Hugo_Symbol, names(crispr_lvlA_bygene)), setdiff(names(crispr_lvlA_bygene), crispr_signif_lvlA$Hugo_Symbol))
crispr_lvlA_bygene <- crispr_lvlA_bygene[match(crispr_lvlA_order, names(crispr_lvlA_bygene))]
bsselect(crispr_lvlA_bygene, type = "img", selected = "KRAS", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)

5.6 JSON testing

g2pA <- read.delim("./data_munging/g2p_full_level_A_dataset_v2_10_10_2018.csv", sep = "\t", header = TRUE, na.strings = "-1", quote = "")
# g2pA[g2pA == "-1"] <- NA
g2pA$X <- NULL

g2pA_JSON <- data.frame(JSON = g2pA$JSON)

g2pA_noJSON <- g2pA
g2pA_noJSON$JSON <- NULL

# write.table(g2pA, file = "./data_munging/g2p_full_level_A_dataset_v2_10_10_2018.tsv", quote = FALSE, sep = "\t", row.names = FALSE)
# write.table(g2pA_noJSON, file = "./data_munging/g2pA_noJSON_v2_10_10_2018.tsv", quote = FALSE, sep = "\t", row.names = FALSE)
# write.table(g2pA_JSON, file = "./data_munging/g2pA_JSON_v2_10_10_2018.tsv", quote = FALSE, sep = "\t", row.names = FALSE)
{
'feature_names': 'ALK positive',
'jax': '{\"responseType\": \"sensitive\", 
        \"efficacyEvidence\": \"Zykadia (ceritinib) is FDA approved for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) in patients previously treated with crizotinib (FDA.gov).\",
        \"molecularProfile\": {\"profileName\": \"ALK positive\",
                               \"id\": 1772},
        \"evidenceType\": \"Actionable\",
        \"indication\": {\"source\": \"DOID\",
                         \"id\": 3908,
                         \"name\": \"non-small cell lung carcinoma\"},
        \"references\": [{\"url\": \"http://www.fda.gov/\",
                          \"id\": 286,
                          \"pubMedId\": null,
                          \"title\": \"FDA.gov\"}],
        \"approvalStatus\": \"FDA approved\",
        \"therapy\": {\"id\": 789,
                      \"therapyName\": \"Ceritinib\"},
        \"id\": 1481}',
'tags': [],
'genes': ['ALK'],
'source_url': 'https://ckb.jax.org/therapy/show/789',
'source': 'jax',
'dev_tags': [],
'gene_identifiers': [{'symbol': 'ALK',
                      'entrez_id': '238',
                      'ensembl_gene_id': 'ENSG00000171094'}],
'association': {'drug_labels': 'CERITINIB',
                'description': 'Zykadia (ceritinib) is FDA approved for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) in patients previously treated with crizotinib (FDA.gov).',
                'publication_url': 'http://www.fda.gov/',
                'source_link': 'https://ckb.jax.org/molecularProfile/show/1772',
                'variant_name': [''],
                'phenotypes': [{'source': 'http://purl.obolibrary.org/obo/DOID_3908',
                                'term': 'non-small cell lung carcinoma',
                                'description': 'non-small cell lung carcinoma',
                                'family': 'lung cancer',
                                'id': 'DOID:3908'}],
                'evidence': [{'info': {'publications': ['http://www.fda.gov/']},
                              'evidenceType': {'sourceName': 'jax'},
                              'description': 'sensitive'}],
                              'environmentalContexts': [{'term': 'CERITINIB',
                                                          'description': 'CERITINIB',
                                                          'taxonomy': {'kingdom': 'Chemical entities',
                                                                       'direct-parent': 'Phenylpiperidines',
                                                                       'class': 'Organoheterocyclic compounds',
                                                                       'subclass': 'Piperidines',
                                                                       'superclass': 'Organic compounds'},
                                                          'source': 'http://rdf.ncbi.nlm.nih.gov/pubchem/compound',
                                                          'usan_stem': 'tyrosine kinase inhibitors',
                                                          'toxicity': 'There is not currently any data on carcinogenicity, effect on human fertility, or on early embryonic development. However, based on its mechanism of action, ceritinib may cause fetal harm when administered to pregnant women and should therefore be administered with effective contraception during treatment. Diarrhea, nausea, vomiting, or abdominal pain occurred in 96% of 255 patients including severe cases in 14% of patients. Drug-induced hepatotoxicity also occurred in 27% of 255 patients, presenting as alanine aminotransferase (ALT) levels greater than 5 times the upper limit of normal (ULN). Severe, life-threatening, or fatal interstitial lung disease (ILD)/pneumonitis, hyperglycaemia, and bradycardia have also been reported.',
                                                          'approved_countries': ['Canada',
                                                                                 'US'],
                                                          'id': 'CID57379345'}],
                'evidence_label': 'A',
                'response_type': 'sensitive',
                'evidence_level': 1},
'features': [{'provenance_rule': 'default_feature',
              'end': 29484957,
              'description': 'ALK  positive',
              'links': ['http://reg.genome.network/refseq/RS000050',
                        'http://reg.genome.network/refseq/RS000026',
                        'http://reg.genome.network/allele/CA425438613',
                        'http://reg.genome.network/refseq/RS000002',
                        'http://myvariant.info/v1/variant/chr2:g.29484957C>G?assembly=hg19',
                        'http://reg.genome.network/refseq/RS001597'],
              'sequence_ontology': {'hierarchy': ['SO:0000400',
                                                  'SO:0000733',
                                                  'SO:0000401',
                                                  'SO:0000119',
                                                  'SO:0000123',
                                                  'SO:0000125'],
                                    'soid': 'SO:0000475',
                                    'root_name': 'sequence_attribute',
                                    'name': 'positively_autoregulated',
                                    'root_soid': 'SO:0000400'},
              'provenance': ['http://myvariant.info/v1/query?q=ALK  positive',
                             'http://reg.genome.network/allele?hgvs=NC_000002.11%3Ag.29484957C%3EG'], 
              'start': 29484957,
              'synonyms': ['NC_000002.11:g.29484957C>G',
                           'NC_000002.10:g.29338461C>G',
                           'LRG_488:g.664476G>C',
                           'chr2:g.29484957C>G',
                           'NG_009445.1:g.664476G>C',
                           'NC_000002.12:g.29262091C>G',
                           'CM000664.1:g.29484957C>G',
                           'CM000664.2:g.29262091C>G'],
              'biomarker_type': 'positive',
              'referenceName': 'GRCh37',
              'geneSymbol': 'ALK',
              'alt': 'G',
              'ref': 'C',
              'chromosome': '2',
              'name': 'ALK  positive'}]
}

6 Heatmaps

6.1 Data management

The mutation status portion of these heatmaps was made using deleterious and missense mutations as “mutant” and all others as “other.”

Make and save heatmap data matrices:

# Set up heatmap data
chm_scores <- t(crispr)
colnames(chm_scores) <- chm_scores[1, ]
chm_scores <- chm_scores[-1, ]
chm_rows <- rownames(chm_scores)
chm_cols <- colnames(chm_scores)
chm_scores <- apply(chm_scores, 2, as.double)
chm_scores <- apply(chm_scores, 2, function(x) (x - mean(x)) / var(x))
colnames(chm_scores) <- chm_cols
rownames(chm_scores) <- chm_rows
saveRDS(chm_scores, "./data_munging/rds/crispr_heatmap_scores.rds")

# Make full grid for genomic features
crispr_grid_ccls <- unique(crispr_data$Broad_ID)
crispr_grid_genes <- unique(crispr_data$Hugo_Symbol)
crispr_grid <- expand.grid("Broad_ID" = crispr_grid_ccls, "Hugo_Symbol" = crispr_grid_genes)

# Gene expression
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))[, c("Hugo_Symbol", "Broad_ID", "RPKM")]
ge_filt$RPKM <- log2(ge_filt$RPKM + 0.0001)
chm_ge_grid <- merge(crispr_grid, ge_filt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
chm_ge <- reshape(chm_ge_grid, idvar = "Hugo_Symbol", timevar = "Broad_ID", direction = "wide")
chm_ge_rows <- chm_ge$Hugo_Symbol
chm_ge$Hugo_Symbol <- NULL
chm_ge_cols <- colnames(chm_ge) %>% gsub("RPKM.", "", .)
chm_ge <- apply(chm_ge, 2, as.double)
chm_ge <- apply(chm_ge, 2, function(x) (x - mean(x, na.rm = TRUE)) / var(x, na.rm = TRUE))
rownames(chm_ge) <- chm_ge_rows
colnames(chm_ge) <- chm_ge_cols
saveRDS(chm_ge, "./data_munging/rds/crispr_heatmap_ge.rds")

# Mutation status
chm_mut_grid <- merge(crispr_grid, maf_df[, c("Broad_ID", "Hugo_Symbol", "Mutation_Status")], by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
chm_mut_grid$Mutation_Status <- ifelse(is.na(chm_mut_grid$Mutation_Status), "Other", chm_mut_grid$Mutation_Status)
chm_mut_grid$Mutation_Status <- ifelse(chm_mut_grid$Mutation_Status == "Other", 0, 1)
chm_mut <- reshape(chm_mut_grid, idvar = "Hugo_Symbol", timevar = "Broad_ID", direction = "wide")
chm_mut_rows <- chm_mut$Hugo_Symbol
chm_mut$Hugo_Symbol <- NULL
chm_mut_cols <- colnames(chm_mut) %>% gsub("Mutation_Status.", "", .)
chm_mut <- matrix(as.numeric(unlist(chm_mut)), nrow = nrow(chm_mut))
rownames(chm_mut) <- chm_mut_rows
colnames(chm_mut) <- chm_mut_cols
saveRDS(chm_mut, "./data_munging/rds/crispr_heatmap_mut.rds")

# Copy number
cn_filt <- filter(cn_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))
chm_cn_grid <- merge(crispr_grid, cn_melt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
chm_cn <- reshape(chm_cn_grid, idvar = "Hugo_Symbol", timevar = "Broad_ID", direction = "wide")
chm_cn_rows <- chm_cn$Hugo_Symbol
chm_cn$Hugo_Symbol <- NULL
chm_cn_cols <- colnames(chm_cn) %>% gsub("Copy_Number.", "", .)
chm_cn <- apply(chm_cn, 2, as.double)
chm_cn <- apply(chm_cn, 2, function(x) (x - mean(x, na.rm = TRUE)) / var(x, na.rm = TRUE))
rownames(chm_cn) <- chm_cn_rows
colnames(chm_cn) <- chm_cn_cols
saveRDS(chm_cn, "./data_munging/rds/crispr_heatmap_cn.rds")

Load heatmap matrices:

chm_scores <- readRDS("./data_munging/rds/crispr_heatmap_scores.rds")
chm_ge <- readRDS("./data_munging/rds/crispr_heatmap_ge.rds")
chm_mut <- readRDS("./data_munging/rds/crispr_heatmap_mut.rds")
chm_cn <- readRDS("./data_munging/rds/crispr_heatmap_cn.rds")

# Metadata anotation dataframe
chm_annot <- merge(merge(data.frame("Broad_ID" = crispr$Broad_ID), crispr_meta[, c("Broad_ID", "cell_line_SSMD", "cas9_activity", "culture_type", "primary_tissue")], by = "Broad_ID", all.x = TRUE), ccl_info[, c("Broad_ID", "Primary.Disease", "Gender", "Source")], by = "Broad_ID", all.x = TRUE)
rownames(chm_annot) <- chm_annot$Broad_ID
chm_annot$Broad_ID <- NULL
colnames(chm_annot) <- c("Cell_Line_SSMD", "Cas9_Activity", "Culture_Type", "Primary_Tissue", "Primary_Disease", "Gender", "Source")
chm_annot$Cell_Line_SSMD <- as.numeric(chm_annot$Cell_Line_SSMD)
chm_annot$Cas9_Activity <- as.numeric(chm_annot$Cas9_Activity)

6.2 All genes, no omics

chm_annot_list <- HeatmapAnnotation(df = chm_annot, annotation_legend_param = list(
  Cell_Line_SSMD = list(title = "Cell Line SSMD", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Cas9_Activity = list(title = "Cas9 Activity", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Culture_Type = list(title = "Culture Type", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Culture Type", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Tissue = list(title = "Primary Tissue", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary_Tissue", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Disease = list(title = "Primary Disease", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary Disease", title_position = "topleft", grid_height = unit(0.3, "in")),
  Gender = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), grid_height = unit(0.3, "in")),
  Source = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Source", title_position = "topleft", grid_height = unit(0.3, "in"))))

chm_all_plot <- Heatmap(chm_scores, name = "CERES Score",
        bottom_annotation = chm_annot_list,
        bottom_annotation_height = unit(5, "in"),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        row_title = "Genes", column_title = "Cancer Cell Lines",
        col = colorRamp2(c(min(chm_scores), 0, max(chm_scores)), c("purple4", "white", "seagreen4")),
        na_col = "black",
        row_title_gp = gpar(fontsize = 30, fontface = "bold"),
        row_names_gp = gpar(fontsize = 5),
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_names_gp = gpar(fontsize = 5),
        row_dend_reorder = TRUE,
        column_dend_reorder = TRUE,
        clustering_distance_rows = "euclidean",
        clustering_distance_columns = "euclidean",
        clustering_method_rows = "complete",
        clustering_method_columns = "complete",
        column_dend_height = unit(2, "in"),
        row_dend_width = unit(4, "in"),
        width = 3)

pdf("./plots_18Q3/crispr_heatmap_euclidean_all.pdf", width = 50, height = 50, paper = "special")
draw(chm_all_plot, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

png("./plots_18Q3/crispr_heatmap_euclidean_all.png", width = 50, height = 50, units = "in", res = 96)
draw(chm_all_plot, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

6.3 CGC genes

Code for heatmap of CGC-filtered genes only

6.3.1 Euclidean distance

chm_scores_cgc <- subset(chm_scores, rownames(chm_scores) %in% cgc$Hugo_Symbol)
chm_ge_cgc <- subset(chm_ge, rownames(chm_ge) %in% cgc$Hugo_Symbol)
chm_mut_cgc <- subset(chm_mut, rownames(chm_mut) %in% cgc$Hugo_Symbol)
chm_cn_cgc <- subset(chm_cn, rownames(chm_cn) %in% cgc$Hugo_Symbol)

chm_annot_list <- HeatmapAnnotation(df = chm_annot, annotation_legend_param = list(
  Cell_Line_SSMD = list(title = "Cell Line SSMD", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Cas9_Activity = list(title = "Cas9 Activity", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Culture_Type = list(title = "Culture Type", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Culture Type", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Tissue = list(title = "Primary Tissue", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary_Tissue", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Disease = list(title = "Primary Disease", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary Disease", title_position = "topleft", grid_height = unit(0.3, "in")),
  Gender = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), grid_height = unit(0.3, "in")),
  Source = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Source", title_position = "topleft", grid_height = unit(0.3, "in"))))

chm_plot_cgc <- Heatmap(chm_scores_cgc, name = "CERES Score",
        bottom_annotation = chm_annot_list,
        bottom_annotation_height = unit(5, "in"),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        row_title = "Genes", column_title = "Cancer Cell Lines",
        col = colorRamp2(c(min(chm_scores_cgc), 0, max(chm_scores_cgc)), c("purple4", "white", "seagreen4")),
        na_col = "black",
        row_title_gp = gpar(fontsize = 30, fontface = "bold"),
        row_names_gp = gpar(fontsize = 5),
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_names_gp = gpar(fontsize = 5),
        row_dend_reorder = TRUE,
        column_dend_reorder = TRUE,
        clustering_distance_rows = "euclidean",
        clustering_distance_columns = "euclidean",
        clustering_method_rows = "complete",
        clustering_method_columns = "complete",
        column_dend_height = unit(2, "in"),
        row_dend_width = unit(4, "in"),
        width = 3)

chm_plot_cgc_cols <- colnames(chm_scores_cgc)[unlist(column_order(chm_plot_cgc))]
chm_plot_cgc_rows <- rownames(chm_scores_cgc)[unlist(row_order(chm_plot_cgc))]

chm_ge_plot_cgc <- Heatmap(chm_ge_cgc, name = "Gene Expression",
        col = colorRamp2(c(min(chm_ge_cgc[!is.na(chm_ge_cgc)]), 0, max(chm_ge_cgc[!is.na(chm_ge_cgc)])), c("dodgerblue4", "white", "firebrick4")),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        na_col = "black",
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Gene Expression",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)
chm_cn_plot_cgc <- Heatmap(chm_cn_cgc, name = "Copy Number",
        col = colorRamp2(c(min(chm_cn_cgc[!is.na(chm_cn_cgc)]), 0, max(chm_cn_cgc[!is.na(chm_cn_cgc)])), c("white", "thistle2", "mediumorchid4")),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        na_col = "black",
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Copy Number",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)
chm_mut_plot_cgc <- Heatmap(chm_mut_cgc, name = "Mutation Status",
        na_col = "black",
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), at = c(0, 1), labels = c("Other", "Mutant"), title_position = "topcenter", grid_height = unit(0.3, "in")),
        col = c("cyan3", "darkorchid"),
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Mutation Status",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)

chm_all_plot_cgc <- chm_plot_cgc + chm_ge_plot_cgc + chm_cn_plot_cgc + chm_mut_plot_cgc

pdf("./plots_18Q3/crispr_heatmap_euclidean_all_cgc.pdf", width = 50, height = 50, paper = "special")
draw(chm_all_plot_cgc, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

png("./plots_18Q3/crispr_heatmap_euclidean_all_cgc.png", width = 50, height = 50, units = "in", res = 96)
draw(chm_all_plot_cgc, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

6.3.2 Pearson correlation

chm_scores_cgc <- subset(chm_scores, rownames(chm_scores) %in% cgc$Hugo_Symbol)
chm_ge_cgc <- subset(chm_ge, rownames(chm_ge) %in% cgc$Hugo_Symbol)
chm_mut_cgc <- subset(chm_mut, rownames(chm_mut) %in% cgc$Hugo_Symbol)
chm_cn_cgc <- subset(chm_cn, rownames(chm_cn) %in% cgc$Hugo_Symbol)

chm_annot_list <- HeatmapAnnotation(df = chm_annot, annotation_legend_param = list(
  Cell_Line_SSMD = list(title = "Cell Line SSMD", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Cas9_Activity = list(title = "Cas9 Activity", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Culture_Type = list(title = "Culture Type", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Culture Type", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Tissue = list(title = "Primary Tissue", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary_Tissue", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Disease = list(title = "Primary Disease", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary Disease", title_position = "topleft", grid_height = unit(0.3, "in")),
  Gender = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), grid_height = unit(0.3, "in")),
  Source = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Source", title_position = "topleft", grid_height = unit(0.3, "in"))))

chm_plot_cgc <- Heatmap(chm_scores_cgc, name = "CERES Score",
        bottom_annotation = chm_annot_list,
        bottom_annotation_height = unit(5, "in"),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        row_title = "Genes", column_title = "Cancer Cell Lines",
        col = colorRamp2(c(min(chm_scores_cgc), 0, max(chm_scores_cgc)), c("purple4", "white", "seagreen4")),
        na_col = "black",
        row_title_gp = gpar(fontsize = 30, fontface = "bold"),
        row_names_gp = gpar(fontsize = 5),
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_names_gp = gpar(fontsize = 5),
        row_dend_reorder = TRUE,
        column_dend_reorder = TRUE,
        clustering_distance_rows = "pearson",
        clustering_distance_columns = "pearson",
        clustering_method_rows = "complete",
        clustering_method_columns = "complete",
        column_dend_height = unit(2, "in"),
        row_dend_width = unit(4, "in"),
        width = 3)

chm_plot_cgc_cols <- colnames(chm_scores_cgc)[unlist(column_order(chm_plot_cgc))]
chm_plot_cgc_rows <- rownames(chm_scores_cgc)[unlist(row_order(chm_plot_cgc))]

chm_ge_plot_cgc <- Heatmap(chm_ge_cgc, name = "Gene Expression",
        col = colorRamp2(c(min(chm_ge_cgc[!is.na(chm_ge_cgc)]), 0, max(chm_ge_cgc[!is.na(chm_ge_cgc)])), c("dodgerblue4", "white", "firebrick4")),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        na_col = "black",
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Gene Expression",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)
chm_cn_plot_cgc <- Heatmap(chm_cn_cgc, name = "Copy Number",
        col = colorRamp2(c(min(chm_cn_cgc[!is.na(chm_cn_cgc)]), 0, max(chm_cn_cgc[!is.na(chm_cn_cgc)])), c("white", "thistle2", "mediumorchid4")),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        na_col = "black",
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Copy Number",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)
chm_mut_plot_cgc <- Heatmap(chm_mut_cgc, name = "Mutation Status",
        na_col = "black",
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), at = c(0, 1), labels = c("Other", "Mutant"), title_position = "topcenter", grid_height = unit(0.3, "in")),
        col = c("cyan3", "darkorchid"),
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Mutation Status",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)

chm_all_plot_cgc <- chm_plot_cgc + chm_ge_plot_cgc + chm_cn_plot_cgc + chm_mut_plot_cgc

pdf("./plots_18Q3/crispr_heatmap_pearson_all_cgc.pdf", width = 50, height = 50, paper = "special")
draw(chm_all_plot_cgc, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

7 Per-gene plots

7.1 Grouped plots

Plot code:

crispr_lvlA_genes <- unique(crispr_data_cgc$Hugo_Symbol)
crispr_all_groups <- lapply(crispr_all_genes, makeCRISPRgrob)
crispr_all_groups_paths <- paste0(crispr_all_genes, "_crispr_grouped.png")
pwalk(list(crispr_all_groups_paths, crispr_all_groups), ggsave, path = "./plots_18Q3/crispr_grouped_plots_cgc", dpi = 300, width = 12, height = 12, units = "in")

Data management:

crispr_all_bygene <- paste0(list.files("./plots_18Q3/crispr_grouped_plots_cgc", full.names = TRUE))
names(crispr_all_bygene) <- str_replace_all(crispr_all_bygene, c("_crispr_grouped.png" = "", "./plots_18Q3/crispr_grouped_plots_cgc/" = ""))
crispr_bygene_order <- c(intersect(crispr_signif$Hugo_Symbol, names(crispr_all_bygene)), setdiff(names(crispr_all_bygene), crispr_signif$Hugo_Symbol))
crispr_all_bygene <- crispr_all_bygene[match(crispr_bygene_order, names(crispr_all_bygene))]
bsselect(crispr_all_bygene, type = "img", selected = "KRAS", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)

7.2 Sorted lineage plots

Plot code:

crispr_data_cgc <- filter(crispr_data, Hugo_Symbol %in% cgc$Hugo_Symbol)
crispr_all_genes <- unique(crispr_data_cgc$Hugo_Symbol)
crispr_all_lins <- lapply(crispr_all_genes, makeCRISPRlinplot)
crispr_all_lins_paths <- paste0(crispr_all_genes, "_crispr_lineage.png")
pwalk(list(crispr_all_lins_paths, crispr_all_lins), ggsave, path = "./plots_18Q3/crispr_lineage_plots_cgc", dpi = 300, width = 12, height = 12, units = "in")

Data management:

crispr_all_bygene <- paste0(list.files("./plots_18Q3/crispr_lineage_plots_cgc", full.names = TRUE))
names(crispr_all_bygene) <- str_replace_all(crispr_all_bygene, c("_crispr_lineage.png" = "", "./plots_18Q3/crispr_lineage_plots_cgc/" = ""))
crispr_bygene_order <- c(intersect(crispr_signif$Hugo_Symbol, names(crispr_all_bygene)), setdiff(names(crispr_all_bygene), crispr_signif$Hugo_Symbol))
crispr_all_bygene <- crispr_all_bygene[match(crispr_bygene_order, names(crispr_all_bygene))]
bsselect(crispr_all_bygene, type = "img", selected = "KRAS", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)

8 Report #2

8.1 Metadata

tissue_summ <- crispr_meta %>% group_by(primary_tissue) %>% tally()
disease_summ <- ccl_info %>% group_by(Primary.Disease) %>% tally()
ggplot(data = tissue_summ) + 
  aes(x = 0, y = n, fill = primary_tissue, label = primary_tissue) +
  geom_histogram(color = "black", stat = "identity") +
  geom_text(position = position_stack(vjust = 0.5)) +
  scale_y_continuous(breaks = seq(0, 500, by = 25), labels = seq(0, 500, by = 25)) +
  coord_cartesian(ylim = c(0, 500)) +
  theme(legend.position = "none", axis.text.x = element_blank(), axis.ticks.x = element_blank(), axis.title.x = element_blank()) +
  labs(y = "Count")

8.2 Scores

Distribution of scores across cell lines and primary tissues. Each data point represents a single cell line.

ceres_summ <- crispr_data %>% group_by(primary_tissue) %>% summarize(Max = max(Score),
                                                                     Min = min(Score))
score_summ_plot <- ggplot(data = crispr_data, aes(x = primary_tissue, color = primary_tissue)) +
  geom_boxplot(mapping = aes(y = Score), outlier.shape = NA) +
  geom_point(data = ceres_summ, mapping = aes(x = primary_tissue, y = Min)) +
  geom_point(data = ceres_summ, mapping = aes(x = primary_tissue, y = Max)) +
  scale_y_continuous(breaks = seq(-4, 6, by = 1), labels = seq(-4, 6, by = 1)) +
  theme(axis.text.x = element_text(angle = 30, hjust = 1), legend.position = "none") +
  labs(x = "Primary Tissue", y = "CERES Score")
score_summ_plot

# ggsave(filename = "./plots_18Q3/crispr/ceres_score_summ_plot.pdf", plot = score_summ_plot, width = 12, height = 4, device = "pdf")

8.3 Mutations

maf_df_filt <- filter(maf_df, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))
# maf_summ_filt <- maf_df_filt %>% group_by(Mutation_Status) %>% tally()
# maf_summ_filt$Percent <- format(round(maf_summ_filt$n / sum(maf_summ_filt$n) * 100, 4), nsmall = 2)
# maf_summ_filt$Percent <- as.numeric(as.character(maf_summ_filt$Percent))

Distribution of mutations across cell lines and primary tissues. Each data point represents a single cell line.

maf_ccl_annot <- merge(maf_df %>% group_by(Broad_ID) %>% tally(), crispr_meta, by = "Broad_ID", all.y = TRUE)

maf_ccl_annot_plot <- ggplot(data = maf_ccl_annot, aes(x = primary_tissue, y = n, color = primary_tissue)) +
  geom_boxplot(outlier.shape = NA, fill = NA) +
  geom_jitter(alpha = 0.7, size = 1, position = position_jitter(w = 0.25)) +
  scale_y_continuous(breaks = seq(0, 9000, by = 1000), labels = seq(0, 9000, by = 1000)) +
  theme(axis.ticks.x = element_blank(), axis.title.x = element_blank(), axis.text.x = element_blank(), legend.position = "none") +
  labs(x = "Primary Tissue", y = "Number of Mutations")
maf_ccl_annot_plot

# ggsave(filename = "./plots_18Q3/crispr/maf_ccl_annot_plot.pdf", plot = maf_ccl_annot_plot, width = 12, height = 4, device = "pdf")
# ggsave(filename = "./plots_18Q3/crispr/score_mut_summ.pdf", plot = grid.draw(rbind(ggplotGrob(maf_ccl_annot_plot), ggplotGrob(score_summ_plot), size = "first")), width = 12, height = 8, device = "pdf")
maf_gene_annot <- maf_df_filt %>% group_by(Hugo_Symbol) %>% tally()

ggplot(data = maf_gene_annot, aes(x = n)) +
  geom_histogram(breaks = seq(0, 600, by = 20), fill = "darkslategray3", color = "black", alpha = 0.7) +
  coord_cartesian(ylim = c(0, 13000)) +
  scale_y_continuous(breaks = seq(0, 13500, by = 500), labels = formatC(seq(0, 13500, by = 500), format = "d")) +
  scale_x_continuous(breaks = seq(0, 600, by = 20), labels = seq(0, 600, by = 20)) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1)) +
  stat_bin(breaks = seq(0, 600, by = 20), geom = "text", colour = "black", size = 2.5, aes(label = ..count..), vjust = -0.2, angle = 45, hjust = -0.1) +
  labs(x = "Number of Mutations", y = "Frequency", title = paste0("Distribution of mutational load for ", length(unique(maf_gene_annot$Hugo_Symbol)), " genes in the CCLE MAF file across all ", length(unique(crispr_ccl$Broad_ID)), " cell lines in the CRISPR screen"))

8.4 Dependency probabilities

drop_prob_100 <- ggplot(data = crispr_data, aes(x = Dep_Prob)) +
  geom_histogram(breaks = seq(0, 1, by = 0.05), fill = "darkslategray3", color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_y_continuous(breaks = seq(0, 5500000, by = 500000), labels = formatC(seq(0, 5500000, by = 500000), format = "d")) +
  stat_bin(breaks = seq(0, 1, by = 0.05), geom = "text", colour = "black", size = 3.5, aes(label = ..count..), vjust = -1) +
  labs(title = "Distribution of all dependency probabilities", x = "Probability of Real Dependency", y = "Frequency")

dep_prob_5 <- ggplot(data = filter(crispr_data, Dep_Prob >= 0.95), aes(x = Dep_Prob)) +
  geom_histogram(mapping = aes(fill = primary_tissue), breaks = seq(0.95, 1, by = 0.005), color = "black") +
  scale_y_continuous(breaks = seq(0, 60000, by = 10000), labels = formatC(seq(0, 60000, by = 10000), format = "d")) +
  theme(legend.position = "bottom") +
  guides(fill = guide_legend(nrow = 4, byrow = FALSE)) +
  stat_bin(breaks = seq(0.95, 1, by = 0.005), geom = "text", color = "black", size = 3.5, aes(label = ..count..), vjust = -1) +
  labs(title = "Distribution of all dependency probabilities > 0.95", x = "Probability of Real Dependency", y = "Frequency", fill = "Primary Tissue")

8.5 Per-gene plots

sig_genes <- c("KRAS", "TP53", "NRAS", "BRAF", "PIK3CA", "PTEN", "CTNNB1")
crispr_sig_genes <- filter(crispr_data, Hugo_Symbol %in% sig_genes)
crispr_sig_genes$Hugo_Symbol <- factor(crispr_sig_genes$Hugo_Symbol, levels = c("KRAS", "TP53", "NRAS", "BRAF", "PIK3CA", "PTEN", "CTNNB1"))

crispr_color <- as.character(crispr_sig_genes$Color)
names(crispr_color) <- crispr_sig_genes$Mutation_Status

# Mutation status
plot_mut <- ggplot(data = crispr_sig_genes, aes(x = Mutation_Status, y = Score, color = Mutation_Status)) +
  geom_boxplot(outlier.shape = NA) +
  geom_jitter(alpha = 0.3, size = 0.7, position = position_jitter(w = 0.05)) +
  facet_wrap(~ Hugo_Symbol, nrow = 7, scales = "free_y") +
  scale_color_manual(values = crispr_color) +
  geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
  theme_light() +
  theme(legend.position = "none") +
  labs(x = "Mutation Status", y = "CERES Score",
       title = "Mutation Status")
# plot_mut

# Copy number
plot_cn <- ggplot(data = crispr_sig_genes, aes(x = Copy_Number, y = Score, color = Mutation_Status)) +
  geom_point(size = 0.5, alpha = 0.5) +
  geom_smooth(method = "lm", size = 0.5) +
  scale_color_manual(values = crispr_color) +
  facet_wrap(~ Hugo_Symbol, nrow = 7, scales = "free") +
  stat_cor(method = "pearson", show.legend = FALSE, label.x.npc = "right", label.y.npc = "top") +
  theme_light() +
  theme(legend.position = "none", axis.title.y = element_blank()) +
  labs(y = "CERES Score", color = "Mutation Status",
       x = "Theoretical Copy number", title = "Copy Number")
# plot_cn

# Gene expression
plot_ge <- ggplot(data = crispr_sig_genes, aes(x = RPKM_log2, y = Score, color = Mutation_Status)) +
  geom_point(size = 0.5, alpha = 0.5) +
  geom_smooth(method = "lm", size = 0.5) +
  facet_wrap(~ Hugo_Symbol, nrow = 7, scales = "free_y") +
  scale_color_manual(values = crispr_color) +
  stat_cor(method = "pearson", show.legend = FALSE, label.x.npc = "left", label.y.npc = "top") +
  theme_light() +
  theme(legend.position = "none", axis.title.y = element_blank()) +
  labs(y = "CERES Score", color = "Mutation Status",
       x = "Gene Expression [log2(RPKM)]",
       title = "Gene Expression")
# plot_ge

# ggsave(filename = "./plots_18Q3/crispr/omics_sig_genes.pdf", plot = grid.draw(cbind(ggplotGrob(plot_mut), ggplotGrob(plot_ge), ggplotGrob(plot_cn), size = "last")), width = 15, height = 18, device = "pdf")

9 shRNA

9.1 Data and annotations

DepMap cell line metadata:

# From figshare
shrna_meta <- read.delim("./data_munging/sample_info_18Q3_shrna.csv", sep = ",", header = TRUE, na.strings = c("", NA))
colnames(shrna_meta)[1] <- "CCLE_Name"

The Achilles shRNA DEMETER score data was pulled from the CTD2 Data Portal (Tsherniak et al 2017).

shrna <- read.table("./data_munging/D2_combined_gene_dep_scores.csv.gz", sep = ",", header = TRUE, check.names = FALSE)
colnames(shrna)[1] <- "Hugo_Symbol"
# Remove Entrez gene IDs from gene names
shrna$Hugo_Symbol <- gsub(" .*", "", shrna$Hugo_Symbol)

# Melt shRNA dataset for merging
shrna_melt <- melt(shrna , id.vars = "Hugo_Symbol", measure.vars = colnames(shrna)[2:ncol(shrna)], variable.name = "CCLE_Name", value.name = "Score")
shrna_melt <- drop_na(shrna_melt)

Merge annotation data:

# Merge cell line metadata
shrna_melt <- merge(shrna_melt, ccl_info, by = "CCLE_Name", all.x = TRUE)
shrna_melt <- merge(shrna_melt, shrna_meta, by = "CCLE_Name", all.x = TRUE)

# Merge mutation annotations
shrna_muts <- merge(shrna_melt, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
shrna_muts <- shrna_muts %>% mutate(Mutation_Status = if_else(is.na(Mutation_Status), "Other", Mutation_Status))
shrna_muts$Hugo_Symbol <- factor(shrna_muts$Hugo_Symbol)

# Summarize number of mutant and Other cell lines
shrna_muts_summ <- shrna_muts %>% group_by(Hugo_Symbol) %>%
  summarize(N_Other = sum(Mutation_Status == "Other"),
            N_Mutant = sum(Mutation_Status == "Mutant"))

# Merge test results back into full dataset, which restores information lost in the summarization
shrna_data <- merge(shrna_muts_summ, shrna_muts, by = "Hugo_Symbol")

# Add Color column
shrna_data$Color <- ifelse(shrna_data$Mutation_Status == "Other", "cyan3", "darkorchid")
shrna_data$Color <- factor(shrna_data$Color)

# Cell line lineages
shrna_data <- merge(shrna_data, ccl_converter, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
levels(shrna_data$lineage_name) <- sort(levels(shrna_data$lineage_name), decreasing = TRUE)

# Copy number
shrna_data <- merge(shrna_data, cn_melt, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)

# Gene expression (RPKM)
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(shrna_data$Hugo_Symbol))
shrna_data <- merge(shrna_data, ge_filt, by = c("Hugo_Symbol", "Broad_ID", "CCLE_Name"), all.x = TRUE)

saveRDS(shrna_data, "./../crispr_lineages_giant_files/shrna_data_18Q3.rds", compress = "xz")
shrna_data <- readRDS("./../crispr_lineages_giant_files/shrna_data_18Q3.rds")
shrna_ccl <- data.frame("Broad_ID" = shrna_data$Broad_ID)

9.2 Wilcoxon tests

9.2.1 Grouped by gene

shrna_signif <- compare_means(Score ~ Mutation_Status, group.by = c("Hugo_Symbol"), data = shrna_data, method = "wilcox.test", p.adjust.method = "BH")
shrna_signif <- adj_signif(shrna_signif)
shrna_signif <- shrna_signif[order(shrna_signif$p),]
saveRDS(shrna_signif, "./data_munging/rds/shrna_signif.rds")
shrna_signif <- readRDS("./data_munging/rds/shrna_signif.rds")

knitr::kable(filter(shrna_signif, p < 0.01)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "shRNA Screen: Wilcoxon Test Results Comparing Mutant and Other Cell Lines, p < 0.1  (Benjamini-Hochberg-corrected p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")

9.2.2 Grouped by gene and lineage

shrna_signif_lineage <- compare_means(Score ~ Mutation_Status, group.by = c("Hugo_Symbol", "lineage_name"), data = shrna_data, method = "wilcox.test", p.adjust.method = "BH")
shrna_signif_lineage <- adj_signif(shrna_signif_lineage)
shrna_signif_lineage <- mutate(shrna_signif_lineage, lineage_name = reorder(lineage_name, p.adj, mean))
saveRDS(shrna_signif_lineage, "./../crispr_lineages_giant_files/shrna_signif_lineage.rds")
shrna_signif_lineage <- readRDS("./../crispr_lineages_giant_files/shrna_signif_lineage.rds")

10 References

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., … Garraway, L. A. (2012). The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 483(7391), 603–607. https://doi.org/10.1038/nature11003

Broad Institute Cancer Dependency Map; Cancer Data Science (2018): Cancer Dependency Map, CRISPR Avana dataset 18Q3 (Avana_public_18Q3). figshare. Fileset. doi:10.6084/m9.figshare.6931364.v1

Consortium, T. C. C. L. E., & Consortium, T. G. of D. S. in C. (2015). Pharmacogenomic agreement between two cancer cell line data sets. Nature, 528(7580), 84–87. https://doi.org/10.1038/nature15736

Data Science, Cancer (2018): DEMETER2 data. figshare. Fileset. doi:10.6084/m9.figshare.6025238.v2

Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E. W., Donovan, K. F., … Root, D. E. (2016). Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nature Biotechnology, 34(2), 184–191. https://doi.org/10.1038/nbt.3437

Meyers, R. M., Bryan, J. G., McFarland, J. M., Weir, B. A., Sizemore, A. E., Xu, H., … Tsherniak, A. (2017). Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature Genetics, 49(12), 1779–1784. https://doi.org/10.1038/ng.3984

McFarland, J. M., Ho, Z. V., Kugener, G., Dempster, J. M., Montgomery, P. G., Bryan, J. G., … Tsherniak, A. (2018). Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. https://doi.org/10.1101/305656

11 Session information

print(sessionInfo())
## R version 3.5.0 (2018-04-23)
## Platform: x86_64-apple-darwin15.6.0 (64-bit)
## Running under: macOS  10.14
## 
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRlapack.dylib
## 
## locale:
## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
## 
## attached base packages:
## [1] parallel  grid      stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] bindrcpp_0.2.2        forcats_0.3.0         stringr_1.3.1        
##  [4] dplyr_0.7.6           purrr_0.2.5           readr_1.1.1          
##  [7] tidyr_0.8.1           tibble_1.4.2          tidyverse_1.2.1      
## [10] rowr_1.1.3            reshape2_1.4.3        plyr_1.8.4           
## [13] NMF_0.21.0            Biobase_2.40.0        BiocGenerics_0.26.0  
## [16] cluster_2.0.7-1       rngtools_1.3.1        pkgmaker_0.27        
## [19] registry_0.5          matrixStats_0.54.0    kableExtra_0.9.0     
## [22] jsonlite_1.5.9000     gridExtra_2.3         glmnet_2.0-16        
## [25] foreach_1.4.4         Matrix_1.2-14         ggord_1.1.2          
## [28] ggfortify_0.4.5       ggsignif_0.4.0        ggpubr_0.1.7.999     
## [31] magrittr_1.5          devtools_1.13.6       data.table_1.11.4    
## [34] ComplexHeatmap_1.18.1 circlize_0.4.4        CePa_0.6             
## [37] caret_6.0-80          ggplot2_3.0.0         lattice_0.20-35      
## [40] bsselectR_0.1.0       broom_0.5.0          
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.3-2    rjson_0.2.20        class_7.3-14       
##  [4] rprojroot_1.3-2     pls_2.6-0           GlobalOptions_0.1.0
##  [7] rstudioapi_0.7      DRR_0.0.3           prodlim_2018.04.18 
## [10] lubridate_1.7.4     xml2_1.2.0          codetools_0.2-15   
## [13] splines_3.5.0       doParallel_1.0.11   robustbase_0.93-1.1
## [16] knitr_1.20          RcppRoll_0.3.0      gridBase_0.4-7     
## [19] ddalpha_1.3.4       kernlab_0.9-26      sfsmisc_1.1-2      
## [22] graph_1.58.0        compiler_3.5.0      httr_1.3.1         
## [25] backports_1.1.2     assertthat_0.2.0    lazyeval_0.2.1     
## [28] cli_1.0.0           htmltools_0.3.6     tools_3.5.0        
## [31] igraph_1.2.1        gtable_0.2.0        glue_1.3.0         
## [34] Rcpp_0.12.18        cellranger_1.1.0    nlme_3.1-137       
## [37] iterators_1.0.10    timeDate_3043.102   gower_0.1.2        
## [40] rvest_0.3.2         DEoptimR_1.0-8      MASS_7.3-50        
## [43] scales_1.0.0        ipred_0.9-6         hms_0.4.2          
## [46] RColorBrewer_1.1-2  yaml_2.1.19         memoise_1.1.0      
## [49] rpart_4.1-13        stringi_1.2.4       highr_0.7          
## [52] bibtex_0.4.2        lava_1.6.2          geometry_0.3-6     
## [55] shape_1.4.4         rlang_0.2.1         pkgconfig_2.0.1    
## [58] evaluate_0.11       bindr_0.1.1         labeling_0.3       
## [61] recipes_0.1.3       htmlwidgets_1.2     CVST_0.2-2         
## [64] tidyselect_0.2.4    R6_2.2.2            dimRed_0.1.0       
## [67] haven_1.1.2         pillar_1.3.0        withr_2.1.2        
## [70] survival_2.42-6     abind_1.4-5         nnet_7.3-12        
## [73] modelr_0.1.2        crayon_1.3.4        rmarkdown_1.10     
## [76] GetoptLong_0.1.7    readxl_1.1.0        Rgraphviz_2.24.0   
## [79] ModelMetrics_1.1.0  digest_0.6.15       xtable_1.8-2       
## [82] stats4_3.5.0        munsell_0.5.0       viridisLite_0.3.0  
## [85] magic_1.5-8